Gene C33H5.16 in Caenorhabditis elegans

Synonym: CELE_C33H5.16, C33H5.16

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP031_AA protein Get Run
CeleP031_AA_34-316 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 26-317 4e-38 126.2 In-house 5-286 (297) alignment 
Range on Protein: 26-317
Range on HMM: 5-286/297.0
DERQKMQKKQIVQFVQTTLEKGpiGLRNEFNAMKRFNDFDKMQSFKKaQDHHKNRYKDVGCLDNNRVKLAHPPWP--HDYIHANFVstPANAKRFICAQA
 ||. .   ..  .||.  .      ..||. . . | . . .. ||  . .|.|||..   | .|||||        ||. | ||  ..| .|.|. | 
kerrpiplsdfatlvqknrhtd..vfseeflclpeaniqpqtvaekk.vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqm

PLDNTCADFWYMCLQERVEAIFMLCNLmEKGAKKCSEYYATKEKPElvFhekdQKITVKYEAsgtvkfVKPTKAVVKETVLIIEGPGGQVLKTTHYHWID
| ..| |||| | |.|.| .| || .. ... |||  |.. |   .  |     ...|. ..      |.  .  .| .. . .|   .      |....
PmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkgvtt..f....Gdvsvvlls......vsereGfikrelevtkgkakarrvvkqyqfve

WPDRGVPP--ADLSIIELLIKAR-----PLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
|||. |.      |...|.   |       .||. |||.||.|||| .. |. .  .  . ....   ....|.|..| . .||. || ||........|
WPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavleall

E
 
s
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 27-320 2.5e-62 205.1 In-house 5-288 (290) alignment 
Range on Protein: 27-320
Range on HMM: 5-288/290.0
ERQKMQKKQIVQFVQTTLEKGPIGLRNEF-NAMKRFNDFDK--MQSFKKAQDHHKNRYKDVGCLDNNRVKLAHpPWPHDYIHANFVSTpaNAKRFICAQA
.|. .| . . .|  .. .|.. .|  |. . .| .   .    . | |  . .||||||| | |  || |     . ||.|||.|        || .| 
nrhsvqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd.GydGdyvhanyvkG..lkamfiltqG

PLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEkdqkITVKYEASGTvkfvkPTKAVVKETVLIIEGPGGQVLKTTHYHWID
.| .|  |.| | |||.| || |||.|.|.|  ||..||  ||   | | |    |||    . .     . . ..| |. . .   |.  |  |.. . 
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe....itvlcseedd.....kdaniikktlsvrdkdsGkehklkhlkiks

WPDRGVPPADLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKiLQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKL
|||. |. ..|... .|   | . ||..|||||||||||. | ||   . ||.| ...  |   . .|. | ||.| | ||| . ......  . | 
wpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldl.vralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_PTPRB_pd Subfamily PTPRB 28-319 9.2e-57 187.3 In-house 4-289 (293) alignment 
Range on Protein: 28-319
Range on HMM: 4-289/293.0
RQKMQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKL--AHPPWPHDYIHANFVSTPANAKRFICAQAPL
 ........ ..|... ..  ... .|.. .| ..   .... ..|... ||||...   |..||||   .     ||| ||...     . || .| ||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

DNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVfhekdQKITVKYEASGTVkfvkptKAVVKETVLIIEgpGGQVLKTTHYHWIDWP
 .|  ||| |........| || .|.||| .|| ||. ..|.| |       .|.|.  |. ..      .  |  ...| .  . .  |...||.. ||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvly.....Gdikvtlvaeeel......edwvirelkiek..ekeerkvrqyhftsWp

DRGVPPADLSIIELLIKAR------PLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKK
| ||| .  ...... . |        |.|| ||||||.||||  . .. . ... . . .. .  |....||.||. .|| .||.|.||...... .|.
dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdif.givaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 29-333 2e-191 629.4 In-house 2-305 (305) alignment 
Range on Protein: 29-333
Range on HMM: 2-305/305.0
QKMQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLaHPPWPHDYIHANFVSTPANAKRFICAQAPLDNT
.|.|||||..||..||||||.|||.||.||||||||.||..||.||...||||||||||||||||| ..||||.|||||.||||.|.|||||.||||..|
kkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplekt

CADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEKDQKITVKYEASGTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRG
||||||||||..||||||||||.|||||||.||.|.|.|..| |.||.|||.||.|.|.|.||.|..||.|.||||.|||||....|.||||||||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPPADLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEVKKA
||.|||.|.|||.||||.||||.|||||||||||||||.||...|||.|..||.|||||||||||||||||||.||||||||..|.|..|||.|||||.|
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea

HADFT
...|.
ykafl
0045450 (Phosphotyrosine protein) phosphatases II 29-317 1e-72 240.8 In-house 7-306 (307) alignment 
Range on Protein: 29-317
Range on HMM: 7-306/307.0
QKMQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFND--FDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPW---PHDYIHANFV--------STPANA
.... ......|...| ... ||. ||. ......   ... .... . ..||||||. ..|..|||| ...    ..|||.|..|        ... . 
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

KRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKeKPELVFHEkdqkITVKYEASGTvkfvkptKAVVKETVLIIEG--PGGQV
..||..|.||..|..||| |. ...|..| ||..|.|.| .|| .|. .. . ||....    .||..    .       .. .. ..| ..   . |..
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtges

LKTTHYHWIDWPDRGVPPADLSIIELLIKARP------LKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQI--EETDKILQKIREQRNNSIQTDHQYL
.. ||.|...||| ||||   ...... ..|        .||..||||||.||||..... .|..|| ... .     .......|||| ...|. .|| 
rtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyr

FVHQVMMNFFLE
|...... ..|.
flyeallelllk
subfamily_PTPRD_pd Subfamily PTPRD 29-315 1.9e-59 196.8 In-house 3-281 (564) alignment 
Range on Protein: 29-315
Range on HMM: 3-281/564.0
QKMQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAqDHHKNRYKDVGCLDNNRVKLAHPPW--PHDYIHANFVSTPANAKRFICAQAPLD
.... ... ..|.    .. . . .|.. ... . | . .. |.|   .||||...   |..||.| . ..    ||| |.|. .  . | .| .|.|| 
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

NTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEkPelvfhEKDQKITVKYEASGTVKFVKPTKAVVKETVliiegpGGQVLKTTHYHWIDWPD
.|..||| |. ..... | || .| ||| .||..|. .|. .     |. ...||. |.. ... .  ..  .|..         .. . ...|...|||
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.t.....etygeltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPd

RGVPPADLSIIELLIKAR----PLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
.|||    |...|. | |    | .||| ||||||.||||  . |..| |.. . ....   ......|.|||  .|| .|| |.|...... 
hgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvD.iyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 29-166 3.8e-18 60.3 In-house 4-154 (350) alignment 
Range on Protein: 29-166
Range on HMM: 4-154/350.0
QKMQKKQIVQFV--QTTLEKGPIGLRNEFNamKRFNDFDKMQsfkKAQDHHKNRYKDVGCLDNNRVKLA----------HPPWPHDYIHANFVSTP----
.|.||.. .. .  . .  | .. |  . .     ||.   .     .   |||||..   . .||||           |   . ||| ||... .    
skvqkrsklkliitknstvksrlsLesdse..spsnDvilse...GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsv

-ANAK-RFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKE
  |.. ..| .|||| .|  ||. ..|.  |. | .| ...| . .|| .|.   .
einpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 29-164 3.2e-12 40.4 In-house 5-155 (349) alignment 
Range on Protein: 29-164
Range on HMM: 5-155/349.0
QKMQKKQIVQFVQTT--LEKGPIGLRNEFNamKRFNDFDKMqsfKKAQDHHKNRYKDVGCLDNNRVKLAHPPW----------------PHDYIHANFVS
.|.||.. .. . |     | .  |  . .     .|.      .  .   ||||||.   .  |||| . .                 ..||| ||...
skvqkrsklkliitkysksksmlslesddd..seiddvils...eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylk

TPA--NAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYAT
 .     |..|. ||||  |  ||. . | ..|. .. | .  |.. .||  |.  
ltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 30-323 4.9e-52 172.0 In-house 4-288 (319) alignment 
Range on Protein: 30-323
Range on HMM: 4-288/319.0
KMQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFdKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPW--PHDYIHANFVSTPANAKRFICAQAPLDN
... ... . ...  ..|  .|..||. .|  ... ...| .| ....||||...   |. ||.|.. .     ||| |.|. .  . ..|| .||||.|
eievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEkpelvfHEKDQKITVKYEASgtvkfvKPTKAVVKETVLIiEGPGGQV--LKTTHYHWIDWP
|  ||| |  .|..  . ||..| ||.  |...|. ...      .|.  ...|. |        . .. ...  . . .   ..|   . .|... .||
tiedfWrmvWeeessivvmltklveklkvklkkywpeen......feeyGrlivtleee......eeledyiirklkl.nkkssevetRevkhfqyteWp

DRGVPPADLSIIELLIK-----ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFlekKL
| .||   .|...|| .      .. .||| ||||||.||||. .... | |.. . . ..   .. ...| |||  .|. .|| |........    . 
dhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlD.vfstvsrlRtqRnimvqrpeqYkfiyealleav...ea

FDE
.| 
gdt
subfamily_PTPN14_pd Subfamily PTPN14 30-315 1.3e-39 131.0 In-house 6-296 (300) alignment 
Range on Protein: 30-315
Range on HMM: 6-296/300.0
KMQKKQIVQFVQTTLEKGPIglRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHP-PWPHDYIHANFVSTPAN--AKRFICAQAPLD
...| . .. ..  ||.| .    |.. ... .   .... |  .. .|||.|||   ..|||.|.      ..|| |  ....     . .| ||.||.
ratkdkrakilekkleegkv..fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPle

NTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKpelvfhekdQKITVKYEAS-GTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWP
.|. ||| |  .. |. | || .  |.| .|. .|.  .|.         .| ||...    | ||.. ...|.  .. .   | ..  .  |  ..|||
ltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles.........kkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWp

DRGVPPADLSIIELLIKAR-------------PLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMM
|.|||.   . .. | . .               | |. ||||||.|||| ... . . . | ....|.  .|.|...||||   .||  || ||..|..
dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvli

NFF
...
kyl
0050432 (Phosphotyrosine protein) phosphatases II 31-318 2.3e-75 249.1 In-house 26-302 (308) alignment 
Range on Protein: 31-318
Range on HMM: 26-302/308.0
MQKKQIVQFVQTtlEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLahpPWPHDYIHANFVSTP--ANAKRFICAQAPLDNT
.  ........    ... .|. ||... .. .  .. .... . ..||||||. ..|..||||   . ..|||.|..|...   . ..||..|.||.||
lsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpnt

CADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEK-PELVFHekdqKITVKYEASGTvkfvkpTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDR
..||| |. ...|. | ||..|.|.| .|| .|. ....   |...    |.||..    .       . ... |. .    .|.... ||.|...||| 
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev......lddytvrtleltnlgdgesrtvthfhytnWpdh

GVPPADLSIIELLIKARPL--KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGnQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEK
||||   .....| ..|    .|||.||||||.|||| ........|||  . .     ....|.||||....||  ||||...... ... |
gvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0051299 (Phosphotyrosine protein) phosphatases II 31-315 5.4e-75 247.8 In-house 5-286 (288) alignment 
Range on Protein: 31-315
Range on HMM: 5-286/288.0
MQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNT
.. ......|...| .|. ||..||... ...   .. .... . ..||||.|. ..|..|||| ...   ..|||.|...... . ..||..|.||.||
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

CADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATkeKPELVFHEkdqkITVKYEASGTvkfvkptKAVVKETVLIIEG-----PGGQVLKTTHYHWID
..||| |. ...|. | ||..|.|.| .||  |. .  .  |....    |||..    .       .. .. ..|...      ..|.... ||.|...
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytn

WPDRGVPPADLSIIELLIKARPL----KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGnQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
||| |||.   .....| ..|      .||..||||||.|||| ........|||... .  .  ......||||....||  ||.||..... ..
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 31-315 2.9e-49 162.9 In-house 9-290 (298) alignment 
Range on Protein: 31-315
Range on HMM: 9-290/298.0
MQKKQIVQFVQTTLEKGPIGLRNEFNAMKRFND---FDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAH--PPWPHDYIHANFVSTPANAKRFICAQAPL
  |... .... . .|. .|. .||. ... ..    ....  .| ....|||| |.  ||  || | .       ||| | |...  . . || .||||
dlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPl

DNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKpelvfhEKDQKITVkyeasgTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWP
 .| .||| |  .| ...| || || |..  |...|. ...|      |.  .|||      ...  .    ... .. . .    .  .  . |.. ||
tetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk......etygeitv......sllskeefadlivrklkvskkkeekerevrqlhftsWp

DRGVPPADLSIIELLIKARPL---KG--PIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
|.|||    |...|| | |      |  |. |.||||.||.|. . |. . |.. . . . .  .... .|..| ...|| .|| |.........
dkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 31-316 2.4e-39 130.1 In-house 6-280 (315) alignment 
Range on Protein: 31-316
Range on HMM: 6-280/315.0
MQKKQIVQFVQTTLEKGPIGLRNEFNAMKRfNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKL--AHPPWPHDYIHANFVSTPANAKRFICAQAPLDNT
.   |.. .|         |........    ..  ..  || ....|||| ..   |. ||.|         ||. |||.   .  .|.|.||.|. ..
ipldqlityvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvas

CADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKekpELVFHEkdQKITVKYEASGTVKFVKPTkavvketvLIIEgpGGQVLKTTHYHWIDWPDRG
  ||| .  .| .  | || ||.|.  .|. .|.  |   .... .    .| | |   |   |.           ..   | .. .   .|.  ||| |
vkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGk..itvtrkseevnteytvrtl........svvf..gdnirevvqlhytswpdmg

VPPADLSIIELLIKARPL----KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
||   .....|  ...       |.| ||||||.||||. . .. . .|.   | |.   ......|..| . .|. .|| |....... |.
vpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 32-319 5.7e-52 171.2 In-house 10-294 (310) alignment 
Range on Protein: 32-319
Range on HMM: 10-294/310.0
QKKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFD-KMQSFKkaQDHHKNRYKDVGCLDNNRVKLAHPP-WPHDYIHANFVSTPANAKRFICAQAPLDNTC
  | . .|. .|   |  || ...  .   .|    ....|  .  ||||| || |||. ||||       .||||||.| |    . |||.| ||. | 
ylkalenfiiateklgieglvkqyrkldakqdssltyeayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhti

ADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVfheKDQKITVKYEASGTVKFVKPTKAVVKETVLIIEGPGG-QVLKTTHYHWIDWPDRG
 ||| | .||| |.|..||. .|.|  ||  |. .    |        ..|   |.|   . .. . . | . | . | |   . |. .  .| .|||||
idfwrmifqeraesilllckvgeegrpkcvgywpslgvtety...gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrg

VPPADLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKK
||      .   . |.  .||  ||||||..|.. || ...  ..| .|.... ....  ... .|   |||. |||....|.. |   ..
vpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifarget
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 32-163 5.8e-15 49.5 In-house 12-139 (302) alignment 
Range on Protein: 32-163
Range on HMM: 12-139/302.0
QKKQIVQFVQTtLEKgpIGLRNEFNAMKRF-NDFDKMQSFKKaqDHHKNRYKDVGCLDNNRVKLAHPpwPHDYIHANFVSTPANAKRFICAQAPLDNTC-
.... ...|.. |..  . ...||.... .  | .| ..|||  . .||. .|| .||.|.|||..   | .|..|  |. |   .  | || |  ..  
eeeeakklvks.ldt..aevkkefkkidtmkvdlekCkafkk..nlkknqsedvpildsnlvkleae..pdsyvnaskvevPeltrsiilaQlpkvdsed

--ADFWYMCLQERVEAIFMLCNLMEKGAkKCSEYYA
  ..|| |  ||..  ...|    |      ||.. 
sveeFWrmvfqekivsvvilvgeeelkk.tlselfp
0043336 (Phosphotyrosine protein) phosphatases II 33-314 1.6e-69 229.8 In-house 4-276 (278) alignment 
Range on Protein: 33-314
Range on HMM: 4-276/278.0
KKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDfDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWP--HDYIHANFVSTPANAKRFICAQAPLDNTCA
 |........ | ... .|..||  . .|.  | .  ... . ..||||||. ..|..|||| . .    .|||.|..|...   ..||..|.||..|..
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYAtkeKPELVFHEkdqkITVKYEASGTvkfvkptKAVVKETVLIIEG-PGGQVLKTTHYHWIDWPDRGV
||| |. ...|. | ||..|.|.| .|| .|.    .  |....    .||..    .       .. .. ..| ..    |.... ||||...||| ||
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgv

PPADLSIIELLIKARP----LKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
|.   .....| ..|      .||..||||||.|||| ........||| ..  .   .......|||| ...||. || |...... .
peslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealley
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 33-320 3.6e-50 165.6 In-house 3-276 (288) alignment 
Range on Protein: 33-320
Range on HMM: 3-276/288.0
KKQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFkkAQDHHKNRYKDVGCLDNNRVKLAhpPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADF
|. |  ...  |. .  ||  |..     .  | ..||   ..  ..||... . |  ||||     |. ||.|| ||.  . .|.|||||||. |   .
kevinawirlvlqiaveglkkeyrdspneasidiidsf..ianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieel

WYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEKdqkitvkyeASGTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPA
| | |.. || | |||.|.||| .|  ||. .|   .  .             . . |  .  . .|| ..| |. .| .     . |. .|.| |||  
WkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPen

DLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIeYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKL
 || . ||   . |. || ||.|||.|||| ...|  .  . |  .      ..|.| ||.| ..|||  |||.||..... .| || 
ylsplrllevlkslqkPivvhssaGvGrtgtlili.lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_PTPN6_pd Subfamily PTPN6 33-317 1.5e-48 160.3 In-house 10-299 (306) alignment 
Range on Protein: 33-317
Range on HMM: 10-299/306.0
KKQIVQFVQTTLEKGPIGLRNEFNAMKRFN---DFDKmQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWPH-DYIHANFVS--TPANAKRFICAQAPLD
.... .. ... ...  |. .||..... .    ... .  .|.. ..||||| .   |..||.|..|  |  ||| ||...  .. . |..| .|  |.
eqrvselekeeeslekagfeeefeelqqeeakkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

NTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELvFHekDQKITVKYEAsgtvkfvKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPD
.| .||| | .||  . | |. . .|.| .||. |. ..|. |  .   . ..|   |        . .. ...| ..  .  ...  .  .||. .|||
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yG..kisvtnvsek.......sladYilRelsvskkkkkkeerevfqyhfksWPd

RGVPPADLSIIELLI----KARPLK----GPIAVHCSAGIGRTGSVVMIEYMCEQLLN-GNQIE-ETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
 |||     ....|     |.. |.    ||| |||||||||||....|. . ... . |.... .  |. ...||||.  .||..|| ||.... ..  
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

E
.
t
0040438 (Phosphotyrosine protein) phosphatases II 34-329 2.2e-76 252.5 In-house 3-290 (317) alignment 
Range on Protein: 34-329
Range on HMM: 3-290/317.0
KQIVQFVQTTLEKGPIGLRNEFNAMKRFNDFdKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPW--PHDYIHANFVSTPANAKRFICAQAPLDNTCAD
......... | ..  .|..||. . ...    .. ... . ..||||.|. ..|..|||| ...   ..|||.|..|..|   ..||..|.||.||..|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATkeKPELVFhekdQKITVKYEASGTvkfvkptKAVVKETVLIIEG-PGGQVLKTTHYHWIDWPDRGVP
|| |. ...|. | ||..|.|.| .|| .|. .  . .|..     ..||..    .       .| .. ..| .|.  ...... ||.|...||| |||
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvp

PADLSIIELLIKARPL----KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEVK
|   .....| ..|      .||..||||||.||||.......|.|||  ....   .......||||....||  || |.......... |  . .  .
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleylkrkltlepase

KAH
...
lkl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 34-314 1.6e-43 143.7 In-house 5-277 (287) alignment 
Range on Protein: 34-314
Range on HMM: 5-277/287.0
KQIVQFVQTTLEKGPIGLRNEFNAMKR-FNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAhpPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADF
... .||..  .||  | .| |  ...  .. |..      |...|||....   ||.|| |      .||| | |. .  ..|.|| |..|. ||  .|
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnf

WYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKpeLVFHEkdQKITVKYEAsGTvkfvkpTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRG---V
| .  ...|.|| |||...|.  ..| .|.....   .|. |   .|..  |   .      .. ....  .. ..  |. .. . |.  .|...|    
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe..yniellnee.vn......agyierklevknknkagdkqqvkqyqitnWdstgkvte

PPADLSIIELLIKA--RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
| . | .||  .|.  .. ...| ||||...||..  . ..   ..  .   |.   ..|.. | |. .|.|| .|| |. ......
pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivley
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 35-318 3.9e-78 257.2 In-house 10-292 (305) alignment 
Range on Protein: 35-318
Range on HMM: 10-292/305.0
QIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQ-----DHHKNRYKDVGCLDNNRVKLAHPPwPHDYIHANFVSTPA-NAKRFICAQAPLDNT
 . |||. .|. |   ||.||  . ..   |  |   .|.     .  ||||.|| | |.. |||..|. | ||||||.|  |    ||||||| |||.|
iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqt

CADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFhekDQKITVkYEASGTVKFVKptKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRG
  .||.| .|..|| | |||. .| |  ||..|. .     | .      | |  . ||.  . .   | .. |.| .   |.| .   | .| .|||||
idefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel...ksgivv.envsgskpmer..daeiqitllnltysgdqkmsvrhlqwtewpdrg

VPPADLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEK
|||. |. .|||   |  | || |||||||||||..| |||. |.. . ..     .... .|.||  |||.| ||||.|.||.|.||||
vppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_PTPRG_pd Subfamily PTPRG 35-327 1.3e-52 173.8 In-house 5-301 (563) alignment 
Range on Protein: 35-327
Range on HMM: 5-301/563.0
QIVQFVQTTLEKGPIGLRNEFNAMKRFNDF--DKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPW---PHDYIHANFVSTPANAKRFICAQAPLDNTC
. .. |     .| ||. .||.|...       .... .| ....|||| ..   |. ||||.  |     .||| ||..     .| || .| || .|.
efakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtf

ADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATkEKPElvfheKDQKITVKYEASGTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGV
 ||| |  ...|. | |. || |.|..||  |. . ...|     . ....|. ... ..      . |.|.. |  .    .... ..||. .||| ||
ddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.dese.....tygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgv

PPADLSIIELLIKA---RPL-KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLE--KKLFDE
|   |  .   .|.   ..   ||| ||||||.||||  .... . .|. . |...   ..|..|| |||. .||  ||.|.|.....  .   ..| .|
PehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavn.vfgflkhiraqRnflvqteEqYiflhdalleaiasketellae

EVKK
.|..
qvee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 35-315 1.7e-50 166.9 In-house 6-280 (318) alignment 
Range on Protein: 35-315
Range on HMM: 6-280/318.0
QIVQFVQTTLEKGPIGLRNEFNAMKR-FNDFDKMQSfKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCAD
.. . |.   |.| . | .|.....|  . . ...|  .  ...|||| ..   |. |||| .       ||| ||..    . | .| ||||| .|. |
dleshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieD

FWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELvfhekdQKITVKYEASgtvkfVKPTKAVVKETVLIIEGpGGQVLKTTHYHWIDWPDRGVPP
|| |  .     | || ...|.| .|.  |.  |.  ..      .|..|. . .     |. .. |..|  .  ..   .. .   ||. .|||.||| 
fWrmvWeqnsavivmltqeeergkakvhryWPskgsrsy......gklvvelkee.....velsdyvlrefkvtrte.eeesrqvrqyhytsWpdegvpe

ADLSIIELLIKARPLK-----GPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
   |...|. ...  .     |||.||||||.||||  .... . |.. . . ..   .. ...|||||  .||..|| |...|.... 
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 35-315 2.5e-44 146.3 In-house 6-283 (290) alignment 
Range on Protein: 35-315
Range on HMM: 6-283/290.0
QIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLA----HPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCA
.  .||..   ||  | ||.|.... ..   ...     .....||....   |.||. |     |.  ...||.| ..    ..|..| .|.|. || .
kfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

DFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPElvFHEkdQKITVKYEASGTvKFVKpTKAVVKETvliieGPGGQVLKTTHYHWIDWPDRG--
||| .  ||.| .| ||.| .|.| .||  |.....  .  . |   .|..  | . . .... .|  ||..       .|.  . |.|.   |.. |  
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..yge..fsikllneetln.eyie.rklevknk.....nsagakqsvtqyqitnwdstgkv

-VPPADLSIIELLIK--ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
  | . |..||  .|   .. ...| ||||...||..  . ..   ..     .|.   ..|.. | |. .|.|| .|| ...|.... .
tnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvid.vfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN9_pd Subfamily PTPN9 35-245 9.5e-37 121.6 In-house 2-204 (297) alignment 
Range on Protein: 35-245
Range on HMM: 2-204/297.0
QIVQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADF
.| ..|.   |||  ||..|. .... .   ... .|.  . .||||.|| |.|. ||.||. .     |||.||||    . | || .| ||..|. ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHekdqKITVKyeasgTVKfVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPA
| |  ...|  | |   ..|.|  ||..|. ..|.    |     ...|.     .|. |. ... .. .. | .   ..  | ||.  . ||| ||| .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvs.....nve.veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss

DLSIIELLIKARP
  |....| |.| 
aaslldvlekvre
subfamily_PTPRN_pd Subfamily PTPRN 36-310 1.2e-32 107.8 In-house 17-287 (297) alignment 
Range on Protein: 36-310
Range on HMM: 17-287/297.0
IVQFVQTTLEKgPIGLRNEFNAMKRFNDFDKMQS-FKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVST-PANAKRFICAQAPLDNTCAD
......  |.. .  |..|..|.....  .. ..  |. .  .|||.|.|   |..|||| .      .||| | ..      |  .| .|.|| .| ||
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvad

FWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEkpELVFHekdqkitvKYEASGTVKFVKPTKAVVKETVLiIEGPGGQVLKTTHYHWIDWPDRGVPP
|| |  .. |  | .|..| |.| |.|..|.  .   . |.|         ||     . .     .|.   |  .    .    | .|.. ||..|||.
fwqmvweqGvvvivnltrleeegvkqckrywpdeG..sevyh........iyevhlvsehiwcddylvrsfyl.knlqtsetrtvtqfhflswpeegvPa

ADLSIIELLIKA----RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQV
.  |..|.  |     |    || ||||.| ||||  ..|. ....||.| .  .    |...|.||.. ..| .|. |. ..
saksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 37-315 1.8e-54 179.8 In-house 9-279 (288) alignment 
Range on Protein: 37-315
Range on HMM: 9-279/288.0
VQFVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAH--PPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWY
|. |. .  ..  |. .|.|..  ..  .. .  ..|....||||...  .| .|||| .       ||| |...    . |..|..|.|| .|  ||| 
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELvFhekdQKITVKYEAsgtvkfVKPTKAVVKETVLIIegPGGQVLKTTHYHWIDWPDRGVPPADL
.  ..... | || .|.|.| .|| ||. ...||.. .     ..||.         .| .. .|....|.     .. |..|.|..  ||| ||| .  
lvyenktstivmltelveggktkCeeYWPdadkpkn.y....Gsvtvtlve......skeledfvlrkllle..kkkteleitqyqylaWpdhgvPeska

SIIELLIK---ARPLK-GPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDkILQKIREQRNNSIQTDHQYLFVHQVMMNFF
 ..||| .   | . . ||| ||||||.||||  . .. . ... . ..|. .. ...|.|.||.. .|| .|| |...|...  
pllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevllsli
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 38-320 1.3e-77 255.8 In-house 5-282 (307) alignment 
Range on Protein: 38-320
Range on HMM: 5-282/307.0
QFVQTTLEKGPIGLRNEFNAMKRFNDF-DKMQSFKKaqDHHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMC
 .|| ||.||   |..||. . . .     ...|.   . .||||.|| | |..|. .  .    ||||||.. .  . |.||||| ||.||  .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsa..ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama

LQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEKDQKITVKYEasgTVKFVKPTKAVVKETVLIIEGpGGQVLKTTHYHWIDWPDRGVPPADLSI
.||.||.. |||...| .  || .|.  .|  .||| |. . |.|.      .| . | . ... | | ..  ...    .|. | .|||||||. .|. 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanl...gakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinlta

IELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKL
|.||   |  . |. ||||||.||.|..| | .. .....|    . .|.....|.||. .|||. |||..|.|....|||.  
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk
subfamily_PTPRK_pd Subfamily PTPRK 38-313 4.7e-43 142.2 In-house 11-275 (314) alignment 
Range on Protein: 38-313
Range on HMM: 11-275/314.0
QFVQTTLEKGPIGLRNEFNAMKRFndfdkMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWP--HDYIHANFVSTPANAKRFICAQAPLDNTCADFWYM
| ...       |...|....         .. || ....|||..|.   |. ||.|         ||| |... .  ... || .| ||..| .||| .
qsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

CLQERVEAIFMLCNLMEKGAKKCSEYYATKEKpeLvfhEKDQKITVkYEASGTVKFVKPTKAVVKetvliIEGPGGQVLKTTHYHWIDWPDRGVPPADLS
 ..|.  .| || .|.|.|. ||..|.  . .       .| |...  |..   ..|. . .| |     .. .  .. .  ..... ||| .||    .
vydencasivmltelvevgrvkClkyWPedte..v...ygdikvel.vetellaelvvrifrvek.....largqeeirevrqfqflgWpdhdvPvsatg

IIELLIK----ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNgNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
...|. .      . .|.| |||||| ||||  ..|. ... . . ... .  .. ...|... | ..|  || |...|...
llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmier.egvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 39-313 2.6e-52 172.9 In-house 12-281 (305) alignment 
Range on Protein: 39-313
Range on HMM: 12-281/305.0
FVQTTLEKGPIGLRNEFNAMKRFndFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWPH--DYIHANFVSTPANAKRFICAQAPLDNTCADFWYMC
... .  .   || ...... .    ....  || ....|||.|..  ||..|..|.. .  .  ||| |..| .  . |..| ||.||.|| ||||.. 
yikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrli

LQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFheKDQKITVKYEASGTVKFVKPTKAVVKETvliiegpGGQVLKTTHYHWIDWPDRGVPPADLSI
..|.|. | ||..|.| | .||  |...... .  |   . ....| |.. .  . .  |. ....         .    ..|.  |||| |||    |.
veekvstivmltklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiede.......dkesrtvlqyqltdWPdhGvpqfatsl

IELLIK---AR-PLKG-PIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMN
..|. .   ..   || |. ||||||.||||  .... . |.| . ....   ..|...|..| . .||  || |.|... .
lslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvd.vfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 39-314 6.4e-48 158.3 In-house 5-275 (281) alignment 
Range on Protein: 39-314
Range on HMM: 5-275/281.0
FVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAH--PPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMC
 .... ..   |. .|.....  .  .  .. |. .. .||||...   |. |||...       ||| ||||..  . |..| .|.|. .....|| | 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

LQERVEAIFMLCNLMEKGAKKCSEYYATKEKpelvfHEKDQKITVKYEASgtvkfvKPTKAVVKETVLIiEGPGGQVLKTTHYHWIDWPDRGVPPADLSI
....|.|| |. . .|.|  ||  |.  ...     . |  ..||| .|.      . ..  .. .. . |  .|.  . .. ... ||| |||     .
weqkvsaivmvtreieagklkChrYWPddns.....elkygdvtvkstae......eekatyierkfkl.eresgetreveqlaytaWPdhGvPattkel

IELLI---K--ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
.|      |   .  | |. .|||||.||||. . .. ..... . ..  . . .....|..||  .||  || ||...... 
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 39-338 7.5e-45 148.0 In-house 9-298 (312) alignment 
Range on Protein: 39-338
Range on HMM: 9-298/312.0
FVQTTLEKGPIGLRNEFNAMKRFNDFDKMQSFKKAQDhhKNRYKDVGCLDNNRVKLAHPpwPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQ
.  . .   |  | .|..|.       .  .| | .|   ||| .. | |  |  ||       |||||||   .. .||.|.|.||.|||. || ..| 
wasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagd..enfyihanfvkictkperfvctqgplentcthfwqlals

ERVEAIFMLCNLMEKGAKKCSEYYATKE-KPELVFHEKDQKITVKYEASGTVKfVKPTKAVVKetvlIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSII
    .| .|| ..| |..||..| .      .|  |    .   . |  |  |  | |. |.|    ..    ||  |  || |  ||| |.| .  .  
lgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggksk.dkithrvlk....vvvkatgqesklnhyqwaswpdhgmpdscdtal

ELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEvKKAHADFTHKYE
 ||   .  | |.  |||||.||||....|| |   |    .  .  ...  .| .|  |...  ||... .....|.  | |.  . .. .. | . | 
rllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkq.nvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn.eqewtkfketya

K
|
k
subfamily_PTPN3_pd Subfamily PTPN3 41-316 2.8e-51 169.1 In-house 9-276 (280) alignment 
Range on Protein: 41-316
Range on HMM: 9-276/280.0
QTTLEKGPIglRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWphDYIHANFVSTPANA----KRFICAQAPLDNTCADFWYMC
. .||.| .    .|. . | .   ...  .|... .||||.|.   |. |||| . .   ||| ||.|.   ..    .|.| .| ||..|..|||.| 
keglesGav..laqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmv

LQERVEAIFMLCNLMEKGAKKCSEYYATkEKPELVFHekDQKITVKYEasgtvkfvKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSI
 ..... | || .|.|.| .|| .|. . .. || .   . ..... |        . ||..|   ... .    .  | ..  ...||| |||    ..
weqksslivmlttlverGrvkChqyWPe.tedeleyg..efsvkceke........detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadf

IELLIKARPLK----GPIAVHCSAGIGRTGSVVMIEYMCEqLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
.|.. . | |.     |. ||||||||||| ....|     |.. ..     .|....|.|| . .|| .|| || . ... . 
lefvervrklrsgkeePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
0039614 (Phosphotyrosine protein) phosphatases II 43-318 1.2e-69 230.4 In-house 26-292 (297) alignment 
Range on Protein: 43-318
Range on HMM: 26-292/297.0
TLEKGPIGLRNEFNAMKRFNDfDkMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP---WPHDYIHANFVSTPAN-AKRFICAQAPLDNTCADFWYMCLQ
.  ... .|..||  ...... | .  ... .  .||||||. ..|..|||| ...    ..|||.|..|...    ..||..|.||..|..||| |. .
ekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

ERVEAIFMLCNLMEKGAkKCSEYYATKEKpelvfheKDQKITVKYEASGTvkfvkptKAVVKETVLIIEGpGGQVLKTTHYHWIDWPDRGVPPADLSIIE
..|..| ||..|.|.|  || .|. ...        .  ..||..    .       .. .. ..| ..  .|.... ||.....||| ||||   ...|
qgvtvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellle

LLIKARP------LKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEK
.| ..|        .||..||||||.||||..... .|.|||  . ..   .......||||....||..|| |...... ... |
flelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN23_pd Subfamily PTPN23 44-312 6.7e-45 148.1 In-house 10-277 (288) alignment 
Range on Protein: 44-312
Range on HMM: 10-277/288.0
LEKGPIGLRNEFNAMKRFNDFDK-MQSFKKAQD-HHKNRYKDVGCLDNNRVKLAhpPWPHDYIHANFVST-PANAKRFICAQAPLDNTCADFWYMCLQER
  .|  .| ..|. ... .| .   .|   |.   .|||..|.   |.|||||       ||| | ||    . .  ||..||||..| .||| |  ...
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

VEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEkdqkitvkyeASGTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELL
.. | || .  |.| .|...|. ...    .| .           | |.| |. |. .|. .. .   .  .| . .| ..  ||. ||| .  .....|
ssviVmllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

IKA--------RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMM
 ..        |..| |. ||||||.|||| . ..    ..| .|| . .. ......|||| ...|. .|. |. ....
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_CG7180_pd Subfamily CG7180 44-317 1.7e-24 81.0 In-house 12-292 (296) alignment 
Range on Protein: 44-317
Range on HMM: 12-292/296.0
LEKGPIGLRNEFNAMKRFNDfDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLA--HPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERV
 .| ..  . |..  .|..  .. .   ...   |||. .|   |.||| |   .     ||| | .| .    | .|  .|| ..|  .|| .  .| .
rrkfrveyklelkltprlei.gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeei

EAIFMLCNLMEKGAkKCSEYYATKEkpelvfHEKDQKITVKYEASGT-----VKFVKPTKAVVKETVlIIEGPGGQVLKTTHYHWIDWPD-RGVPPADLS
.|. .|.. ..    .. .|.  |       .|. ..| |..  . .      . .| || .|  |    ..   ..   .....  |.    ||    .
savvvLtktfdfak.mypsywpnks......keqygeifveiveekqyanlkirtfkltkkivalte.qekqvkaetRivklfqlteWeledkvPlstna

IIELLIKA---------RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLE
.|||. ..         .| .||. |..| | .|.|  . |.   |.. . ....   . ....|..|.. ... ..| .. .|. ...| 
lielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevd.vFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Ptp69D_pd Subfamily Ptp69D 45-325 7.7e-49 161.5 In-house 18-295 (307) alignment 
Range on Protein: 45-325
Range on HMM: 18-295/307.0
EKGPIGLRNEFNAMKRFnDFDKMQSF-KKAQDHHKNRYKDVGCLDNNRVKLAHPPWP--HDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERV
..   || .|.. ...   .||  .. .|  .  ||||.|.   |..||||.. .     ||| |.|. .  . |.||.||.|...|  ||| |  .  |
rdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqev

EAIFMLCNLMEKGAKKCSEYYATKekPELVFHekdqKITVKYEA-SGTVKFVKPTKAVVKETVLIIEGpgGQVLKTTHYHWIDWPDRGVPPADLSIIELL
. | || || ||  |||. |..     |  .     .| ||.   . . .... .  | |      |    .  | . ||.  |.|  || .  ....|.
tlivmlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkeesgev..edsrkvvqyhytgWkDskvPevargllkli

IKA----RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLeKKLFDEEV
 ..    .  ..|| |||||| ||.| .| .. . .|| . ....   .. ...|.|||  .|  .|| |... ....   .   ||.|
eqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif.etvkdLrsqRnllvqsleqYvflyralldyss.ygdtdedv
0047943 (Phosphotyrosine protein) phosphatases II 48-315 2.2e-71 235.8 In-house 11-272 (273) alignment 
Range on Protein: 48-315
Range on HMM: 11-272/273.0
PIGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLahPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFML
. .|. ||...... .  ... ... . ..||||||. ..|..||||  .. ..|||.|..|...   ..||..|.||.||..||| |. ...|. | ||
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

CNLMEKGAKKCSEYYATKEKP-ELVFHEkdqkITVKYEASGTvkfvkptKAVVKETVLIIEG-PGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARP
..|.|.| .||  |. ...   .|....    .||..    |       |. .. ..|...    |.... ||.|. .||| ||||   |..|.. ..| 
telvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

------LKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
       .||..||||||.||||..........||  ....   .......|.|| ...||  ||.|.........
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 49-329 5.8e-76 250.9 In-house 13-291 (297) alignment 
Range on Protein: 49-329
Range on HMM: 13-291/297.0
IGLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLahPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLC
 .|. ||  . ..    ..  ... .  .||||||. ..|..||||  .. ..|||.|..|...   ..||..|.||.||..||| |.....|. | ||.
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NLMEKGAKKCSEYYATKEKPELVFhekdQKITVKYEASGTVkfvkpTKAVVKETVLIIEG-PGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARP--
.|.|.| .|| .|. ..|  .|..     ..||..    .|     ... .. ..| ..   .|.... ||.|...||| |||.   |..... ..|   
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----LKGPIAVHCSAGIGRTGSVVMIEYMCEQLLN--GNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEVKKAH
     .||. ||||||.||.|.......|..|| .   ..     ....|.||||....||  ||.|.......... |... . .|...
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
0046845 (Phosphotyrosine protein) phosphatases II 50-318 1.6e-72 239.6 In-house 1-277 (284) alignment 
Range on Protein: 50-318
Range on HMM: 1-277/284.0
GLRNEFNAMKRFNDFD--KMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWP---HDYIHANFVSTP-----ANAKRFICAQAPLDNTCADFWYMCLQE
||. || .. ... .   ..  ... . ..||||||. ..|..|||| ...     .|||.|..|...      . |.||..|.||.||..||| |....
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

RVEAIFMLCNLMEKGAKKCSEYYATKeKPELVFhekdQKITVKYEASGTvkfvkptKAVVKETVL--IIEGPGGQVLKTTHYHWIDWPDRGVPPADLSII
.|. | ||..|.|.| .||. |. .. .  |..     ..||..    .       |  .. ..|    .|..|.... ||.|...|||.||||   ...
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.......kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedll

ELLIKARPL------KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQ--IEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEK
|.| ..| |      .|||.||||||.|||| ........||| ....       ......||||....||  ||.||......... |
eflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_PTPRA_pd Subfamily PTPRA 50-317 1.8e-43 143.7 In-house 33-297 (330) alignment 
Range on Protein: 50-317
Range on HMM: 33-297/330.0
GLRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFML
 .|.||||.   .    ..  .| ....|||. ..   | .|| |..       ||| | |.    . ..|| || |...|  ||| |  . .  .| ||
lfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativml

CNLMEKGAKKCSEYYATKEkpeLVFHeKDqkITVKYEASGTVKFVKPTKAVVKETVLIIEGpgGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPL-
 .| |.  .||  |. ..    || .  .  |.|. | .  .. .   | .|..     .    ..   . .|.  ||| |||     ...|| | . | 
telkerkeekcaqywPdeG...lvty.Gn..irvevedetvlvdytvrkflvqqlpdatre..kksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln

---KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNgNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLE
    ||| ||||||.||||. .... . |..   ... .  ......| || . .||| || |...|.....| 
qqsagpivvhcsaGvGrtGtfivldavlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
DSPc_SM00195 51-315 4.1e-73 241.3 In-house 2-262 (263) alignment 
Range on Protein: 51-315
Range on HMM: 2-262/263.0
LRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLC
|..||. ... .  ..... .| . ..|||||.. . |..|||| ...   ..|||.||..... . |..|..|.||..|..||| |...|.|. | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLMEKGAKKCSEYYATKEKPELVFHekdqKITVKYEASGTVKfvkptKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPL--
. .|.| .||..|.  ... . .|.    ||.||     ..|     . ....|. . .    .  |.|.|.. .|||.|||    |..||| ...    
eeeengkekcdrywpeesggketfg....kisvklvevekkk.....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksks

--KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
  .||| ||||||.||||..|.|......| ..... . ..|....|.|| ...||. ||||.........
tssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 51-315 4.1e-73 241.3 In-house 2-262 (263) alignment 
Range on Protein: 51-315
Range on HMM: 2-262/263.0
LRNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLC
|..||. ... .  ..... .| . ..|||||.. . |..|||| ...   ..|||.||..... . |..|..|.||..|..||| |...|.|. | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLMEKGAKKCSEYYATKEKPELVFHekdqKITVKYEASGTVKfvkptKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPL--
. .|.| .||..|.  ... . .|.    ||.||     ..|     . ....|. . .    .  |.|.|.. .|||.|||    |..||| ...    
eeeengkekcdrywpeesggketfg....kisvklvevekkk.....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksks

--KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
  .||| ||||||.||||..|.|......| ..... . ..|....|.|| ...||. ||||.........
tssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN12_pd Subfamily PTPN12 51-317 6.7e-55 181.0 In-house 17-279 (290) alignment 
Range on Protein: 51-317
Range on HMM: 17-279/290.0
LRNEFNAMKRFNDFDKMqSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWP--HDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLC
|... ...|. . . .  . .| .. .||||||.   |..||.| .       ||| |||.  ... ...| ||.|| .|  ||| |  . .|| . |.|
lkklsekykaekvyste.agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaC

NLMEKGAKKCSEYYATKEKPELVFHekDQKITVKYEASGTVKFVKPTKAVVKEtvliiegpgGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLK-
...| | |||  |.. . . || |   . ..|.. |   .  |.  | .| ..         ..  | . .|. .|||.||| .  |..||. ..| |. 
revelgkkkCerYWpeegeeelefg..efevtleeekavdddflirtLkveaq.........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

---GPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETD--KILQKIREQRNNSIQTDHQYLFVHQVMMNFFLE
    |..||||||.|||| .. |.|. |.| ...  || |  ......|.||.  .||  || .|.. ..... .
sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 51-315 1.4e-35 117.4 In-house 17-293 (301) alignment 
Range on Protein: 51-315
Range on HMM: 17-293/301.0
LRNEFNAMKRFNDFDKMQSFKkAQDHHKNRYKDVGCLDNNRVKLAHPPW----PHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFM
. ......|. .|   . ...  .... ||.|..  .|.||. |.. |      ..|| |....   ..|.|| ||.|...| .||| . .||.. .| |
feeqykelkegedksctvgls.eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LCNLMEKGAKKCSEYYATKEKPELVFHEKDQKITVKY------EASGTVKFVKPTKAVVKETVLIIEGPGgQVLKTTHYHWIDWPDRGV---PPADLSII
..|| |.  .|| .|. . |. .  | .   ... ..        . .||  . ..    |  . ..    .  . . .. .|||. ||   |   | .|
vtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqvi

ELLIKA--RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLlNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
.  |..  .. .||. ||||....|.|  . ..   ||    . . .  .. . .| ..   ..|  || ....|.  ..
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 51-314 6e-23 76.2 In-house 8-258 (267) alignment 
Range on Protein: 51-314
Range on HMM: 8-258/267.0
LRNEFNAMKRFNDFDKMQSFKKA-QDHHKNRYKDVGCLDNNRVKLAHPpwPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCN
...||. .|.  |     |   | . . .||. |.   |..|| |      ..|| | .| .    . ||  | ||.|| .||. .  ...|  | .| .
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk..eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk

LMEkgaKKCSEYYatkeKPELVFHEKDQKITVKYEASgtvKFVKPTKAVVKETVLIIEgpggQVLKTTHYHWIDWPDR-GVPPADLSIIELLIKARPLKG
  .    .   ..     |..   .| | .||..      |  .  . .. |  .  |       . | |..  |       |    .. .| | .  .|
vft...dnirlfw....PPkmgqakkyqdltvehsle...keendyqiitlelkfkne....sahnvtlyyykkwnintnnkpylkplfgilaknqleng

--PIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
  |. |.||.|.||.|. ..|. . |.. . .   .  . |.|||.||   ..|  .|...|... ..
nrPlvvacsdGvGrsGtflvidsqleraktegvs.difdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPN13_pd Subfamily PTPN13 52-313 1.9e-50 166.7 In-house 14-267 (273) alignment 
Range on Protein: 52-313
Range on HMM: 14-267/273.0
RNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWphdYIHANFVSTPANAKRF--ICAQAPLDNTCADFWYMCLQERVEAIFMLCN
 .||. .. .   |. .. ||.....||||..|   |. ||||        || |...  | . ...  | .| || .|..||| |  . ..| | |. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

LMEKGAKKCSEYYATKEKPELVFHEkdqKITVKYeasgtVKFVKpTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLKG-
  |||  ||  |.  ... .|. ..   ...|.      .| .|  .. |  .. ...   |.. . .| ....||| ||| . ....... . | |.  
ekekgkvkchrywPesknkklkvsn...rlevel.....lkvqk.ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd

--PIAVHCSAGIGRTGSVVMIEYMCEqLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
  ||.|||||||||.|... |. . . |.. ..  .  .|..|.||||.  .||. ||.||......
agPivvhcsaGiGrsGtlitidvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 52-325 8.1e-45 147.6 In-house 14-279 (281) alignment 
Range on Protein: 52-325
Range on HMM: 14-279/281.0
RNEFNAMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAH--PP-WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLC
..||  .      |    |..  . .|||| .. |||  ||.|    |     ||||||.. .|   . .| .| |  .| |||| |  ||   || |||
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

NLMEKGAKKCSEYYATKEKPELVFhekdQKITVKYEASGTVKFVKPTKavvkeTVLIIEgpgGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLKG
...|   .||.||.  . .  | |    .|..|.|| |   | .  |.       |  |   |.    ||. | .|||  || .   ....| | |    
qfletnrekcaeyfprnahcclqf....dklsvsyedstvnkslvttr.....lnlsye...getrlithwlwkewpdwqvpessevmlkilrkirarst

PIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIRE-QRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEV
|  .|||||.||.|... .|   . . .   . .  .|. ..|   |  |.|| .||... .|...| .  |   ||.
ppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqiteel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 52-317 1.1e-34 115.1 In-house 26-290 (325) alignment 
Range on Protein: 52-317
Range on HMM: 26-290/325.0
RNEFNAMKRFNDFDKmQSFKKAQDHHKNRYKDVGCLDNNRVKLAHP-PW-PHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERvEAIFMLCN
 .||. .   .   | .   | ..  |||.|.|  ||..|| |         ||| |... .  . . |. ||||| .|  |.| . |. |  .. .. |
ahefgllpsddgiak.kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvln

LMEKGAKKCSEYYATKEKPELVFHEKDQKITVKYEASGTVKFVKPTKAVvketvliiegPGGQVLKTTHYHWIDWPDRGVP--PADLSIIELLIK-----
 ...| ..|. |.  .      |   . |.    | |  |. |   | |           .|. .    ...  |.| ||.  || |  |  |.|     
eldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqv..........kkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

--A-RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLE
  |     .|| ||||||.||||  . .  . .....  ...   . ..|.|..| . ..|  || .... ...... 
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdif.gfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 53-337 7.9e-39 128.8 In-house 38-308 (319) alignment 
Range on Protein: 53-337
Range on HMM: 38-308/319.0
NEFNAMKRFN-DFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCn
 ||... .   .  ...     |.  |||. ..   |.|.||| .       ||| | ||.   . ...| || ||||| |||| |  . .. .| .|  
vefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt.

lmekgAKKCSEYYATKEkpelVFHEKDQKITVKY--EASGtvkfvkptkAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPL-
      .|||.|.  |     | .|.  |. |.   |..           ||..  |  .|   .. | | .|.  ||| |||     .. |. | | | 
.....kdkcsqywplki....vikeerfkvkvdsveetae.........yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlt

-----KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMmnffLEKKLFDEeVKKAHADFTHKYE
     . .| ||||||.||||  .... . ... . .|..   .... .|.|||. .|   || |..  .    ||..||      |  ||   .|
skenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysal....leehlfgh.sdvampdfpayle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 53-315 3.6e-36 119.4 In-house 14-277 (287) alignment 
Range on Protein: 53-315
Range on HMM: 14-277/287.0
NEFNAMKRFNdFDKMQSFKKAQDH---HKNRYKDVGCLDNNRVKLAHPP-WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLC
.|..|.|.         ||.|..    .|||| ||  .|..|| |.. .    ||| ||.|..  . ..||.||.|.  |  ||| . |..|. .. .. 
kevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmt

NLMEKGAKKCSEYYATKEKPELVFhekDQKITVKYEasgtvKFVKPTKAVVKETVLIIEGPGGQVLKTthYHWIDWPDRGVPPADLSIIELLIKA-----
  .|.. .|| .|.  .|.| .|       ...        .  .|  .|    .. .|.   .|.|   .....|||....|. ...| . ..      
reveearlkcykywPerevPmrvG...Gysvvlldy.....dikePeygvralrlidletrearvvkq..ldllswPdkvlaPtavglirfvldvkqhie

--R--PLKGPIAVHCSAGIGRTGSVVMIeYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
  |     ||. ||...||||.| .. . ... . |.     .. ... ..||.|.  .|.  |. .. . .. ..
lardasevGPlvvhddvGiGrsGillat.lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 53-316 8.9e-33 108.2 In-house 24-237 (392) alignment 
Range on Protein: 53-316
Range on HMM: 24-237/392.0
NEFNAMKRfNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKL--AHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNL
.||  .    |  . .. .|  . .|||||..  .|..||||        .||. | .. .  | | .|..|.|   .  ||| | .||.| .| |. .|
eefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl

MEKGakkcseyyatkekpelvfhekdqkitvkyeasgtvkfvkptkavvketvliiegPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLKG--
 |                                                         | ..   . .|. .|||..||    |..... . .   |  
kegd......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy

--PIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
  |. .|||||.|||| |. |. .  .  .   . .  ... .||..|   .||. || |..  ... .|
thpliihcsagvgrtgvvisidsvvahakktrmv.dvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 54-313 2.2e-38 126.8 In-house 11-264 (283) alignment 
Range on Protein: 54-313
Range on HMM: 11-264/283.0
EFNAMKRFNDFDKMQSFKKAQ-DHHKNRYKDVGCLDNNRVKLAhpPWPHDYIHANFVS---TPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCN
 .. .||..  |.    . |. ...|||....   |..||.|   . ..||| | |.       . |..| ||.|||.|  ||| |  .|.. || || .
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelk..sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

LMEKGAKKCSEYYATKEKPElvFHekDQKITVKYEAsGTVKFVKptkavvKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSI--IELLI--KARP
|.|   .||| |.  .   .  .   .  .|.. |  .   |..      || .|  ..   . |  .||  ||| . |  .   |.  ....|  . . 
lqedlrikCsqyWPkrGsed..yG..eftvtlrket.tsnsfii......kelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

LKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGnQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
 |||| ||||.|||||.  . .    ...|    . .  .... .||||   .||  || .||.....
kkgPivvhCstgiGrtavfiaasasvkdalte.svvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_eak_pd Subfamily eak 55-181 1.3e-09 31.9 In-house 29-156 (332) alignment 
Range on Protein: 55-181
Range on HMM: 29-156/332.0
FNAMKRFNDFDKMQSFKKAQ---DHHKNRYKDVgCLDNNRVKLAHPP-WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNL
 | .. ..|. ...| ....   . ..| .| |   | . |.|.     .  || |  .  .   ...| . .. ..    || | |...  || .| . 
inivadlddyqrllsisetarleavnrnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlled

MEKGAKKCSEYYATKEKPELVFHEKDqkITV
.|.. .|   |.  | . || |   |  .. 
velkleksdkyfpdktreelkfGild..ver
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 55-162 4.8e-08 26.8 In-house 19-122 (332) alignment 
Range on Protein: 55-162
Range on HMM: 19-122/332.0
FNAMKRFNDFDKMQsfkkaQDHHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVSTPANAKRFICAQAPL-DNTCADFWYMCLQERVEAIFMLCNLMEK
 .||   | .||.      ..   ||   . |.| .||.||      |.  |..|   ..   .| ||||. | |   || |  . .   |... .. ||
tsamtypntydkfl.....nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek

GAKKCSEYY
  .|.    
qkrkapydi
0045098 (Phosphotyrosine protein) phosphatases II 57-317 3.7e-65 215.4 In-house 15-274 (278) alignment 
Range on Protein: 57-317
Range on HMM: 15-274/278.0
AMKRFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKlahppwphDYIHANFVSTPaNaKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAK
   . ......  . .  . .||||||. ..|..|||        |||.|...... . |.||..|.||..|.|||| |. ......| ||..|.|.| .
fllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

KCSEYYATkeKPELVFhekdQKITVKYEASGTVkfVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPAD-----LSIIELLIKARP------
|| .|.    .  |..     ..||...   ..   . |. . . | | .| .... .. ||.|.. ||| |||. .     |...| . .|.       
kcaqywpe..ggslty....gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

--------LKGPIAVHCSAGIGRTGSVVMIEYMCEQLlngNQIEETDKILQKIREQRNN-SIQTDHQYLFVHQVMMNFFLE
         .||..||||||.|||| .|.. .|.|.|   ..    .......|.||.. ..|. .|| |...... ..| 
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_egg_pd Subfamily egg 60-317 1.8e-35 117.1 In-house 25-272 (307) alignment 
Range on Protein: 60-317
Range on HMM: 25-272/307.0
RFNDFDKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHP--PWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKgaKK
   |   ..   ..   .| | | | | |  ||||  .   .  |.|||| |.       ||.||||| ||  ||| |  ||.|. | ||    |   ..
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CSEYYATKEKPELVFHEKDQKITvkyeASGTVKFVKPTKAVVKETVliiEGPGGQVLKTTHYHWiDWPDRGVPpadLSIIELLIKARPLKGPIAVHCSAG
|  |.   |.  ||.     .|.    . .  .   |   | |  .    |.  . .   |. . |.   .      | ...| |.| |  |. |..  |
ceyywpkaesdslvtvpGslrie....nlkvdskadplfrvtklkl...vGgddeerflehwqg.dvnnssdv...ysplrvlrklrnlskpvvvqdilG

IGRTGSVVMIEYMCEQLLNGNQIE-ETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLE
. .....| ||    .|| |        .  . .| .|. |...  .||||..... || .
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 63-174 8.9e-06 17.4 In-house 19-117 (275) alignment 
Range on Protein: 63-174
Range on HMM: 19-117/275.0
DFDKMQSFKKaqDHHKNRYKDVGCLDNNRVKLAHppwpHDYIHANFVSTPANakRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAkkcseYY
| .|.. | .  . .|||. .| |.|.   .  .    . ..||| . ||     |. .||| |.| ||. ..     |...  |    | |      |.
ddekierfir..ngeknrftnvtcfdeildrenq....effvhantfrtpyg..nflisqapndstnadhlhllwiynvqtvvclvlpeeagg.....yf

ATKEKPELVFHE
  ||   .   .
vpkegetftsfq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 64-316 6.4e-39 128.6 In-house 33-278 (315) alignment 
Range on Protein: 64-316
Range on HMM: 33-278/315.0
FDKMQSFKKAQDHHKNRYKDVGCLDNNRVKL--AHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEY
  . .. .. ....|||||..  ||..||||        .||| | .. .  . | .|..|.||. .  ||| | |||.| .| |. .. |    ||  |
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

YATKEKPELVFHEKdQKItvkyeasgTVKFVKPTKAVVKETvliIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLI--KA--RPLKGPIAVHCSAG
.  ..     | .  .          ...    | .|...    .   . .  . | ... .|||.||.    |...|.   ||  .. . .. ||||||
wPdrkadsvefGsi.kve........llsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaG

IGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
.|||| |. |. . .|. ... ..   ......|..|   .||. .| |....... .|
vGrtGvvisidevvaqikrtrsvd.vfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 65-322 9e-47 154.3 In-house 40-288 (301) alignment 
Range on Protein: 65-322
Range on HMM: 40-288/301.0
DKMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPwPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYAT
|...       ..|.||. | |  .  |..         ||||...|. ...|||..|.||.||. ||| |. |  || | ||.. .||  .||.||...
dhitesyaylpkdkhryptvPckPstavevivdG.krvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

KEKPELVFHEkdQKITVKyeasgtVKFVKPTKAVVKETVLIIEGPGGQVLKT-THYHWIDWPDRGVPPADLSIIELLIKARPLKGPIAVHCSAGIGRTGS
| . .|       ||..|       | .   | ..| |. . .  |    .| ||| . .|.||||| .   . .|.  ..  . || |||||||||. .
kisekldigr..fkikik......nkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsva

VVMIEYMCEQLLNGNQIEETDkILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFD
 .  ||.  .... ..|| |.  |...||.| |..|| .|  ..    .  .  .. ||
figteylareveadptielte.alkhlrehrwngvqtnsqlywmtlGtvyrlikeygfd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 66-231 7e-27 89.0 In-house 24-181 (297) alignment 
Range on Protein: 66-231
Range on HMM: 24-181/297.0
KMQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVSTPANAK--RFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYA
.. | |.    .||||.|.   |..||||   .  .||| |..|  | . .  ..|.|| ||..|  ||| .  .. | .| |...| | | .||  |. 
sfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

TKEKPELvfheKDQKITVKYEASGTVKFvkpTKAVVKETVLIIEgpgGQVLKTTHYHWIDWPDRGVPP
  ..  |    |  .. |.. .| . .|    . .. |  ||      .  . .|  .. ||| ||| 
svvqerl....kagdvvveflsstsdef...drviltelqliyr...sesrvvrhvqflswpdhGvps
subfamily_PTPN1_pd Subfamily PTPN1 67-313 1.6e-45 150.0 In-house 24-269 (290) alignment 
Range on Protein: 67-313
Range on HMM: 24-269/290.0
MQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWphDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKE
... |. ... .|||.||   |  |.|| .     ||| |..|  .   ...| .| || ||.. || |  ...  |. || ...||.  || .|. ..|
treaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

K-PELVFHEKdqKITVKYEASGTVKFVkptkavVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARP------LKGPIAVHCSAGIG
.  ||....   |..||. .  . ..       . ... . .    .  . .|.|.. ||| ||| .  . ...| | |        .||  .|||||||
eekellledt..klkvkliseerksyy......tvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGSVVMIEYMCEQLLNGNQI--EETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
|.|...... .  .. . ...   .  | | ..|..|   |||  |  | .. ...
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 67-314 4.1e-44 145.7 In-house 20-267 (274) alignment 
Range on Protein: 67-314
Range on HMM: 20-267/274.0
MQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWP---HDYIHANFVSTPAN-AKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYY
..  . .  ..|||||..   .| || | .        .|| ||..  . .  | .. .| || || |||| |  ||.|. | || .| |.  .||..|.
qeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyf

ATKEKPELvfHEKDQKITVKYEasgtvKFVKPTKAVVKETVLIIEGP--GgqvlkTTHYHWIDWPDRGVPPADLSIIELLIKA------RPLK-GPIAVH
 ..|. |.  .|. ... .| |     | |.  .  |.. ||              .|| . ||||. .|    ....|. .       .  | .|. ||
Pdaedyei..serygdveikve.....kiverndysvrklvlkylerers.....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvh

CSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
|||||||||  . |.  . || . . ..   ||  ..| .|   .||..|| ..|.... .
CsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 67-332 6.3e-22 72.5 In-house 39-296 (303) alignment 
Range on Protein: 67-332
Range on HMM: 39-296/303.0
MQSFKKAQDHHKNRYKDVGCLDNNRVKLAHppwpHDYIHANFVSTPAnAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKgAKKCSEYYATKE
.   .  .. .|||. || |||  .|||.       ||||...   .  |. | .| ||  |.|||| | ....|  ...|    |   |   ..   ..
vsknqfvknmdknrfvdvicldhskvklsd....ssyihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdsey.dklggdsvfprn

KPELVFHEKdqKITVkyeasGTVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHwiDWPDRGVPPA-------D-LSIIELLIKARPLKGPIAVhCSAGI
.  | | |.   | |     |  | |. ..  |   . . .|     |.  ||.  .||   .|         .   .  .| |  . . .. .   .| 
qdflkfeer..sirv.....gefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvym.slsgc

GRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEVKKAHADF
||.|.  ..|     | . .   .  | |...|. |  ..|   |. .|. .. .  |.. .    . |   | 
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpnde
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 67-194 1.8e-11 38.1 In-house 88-206 (244) alignment 
Range on Protein: 67-194
Range on HMM: 88-206/244.0
MQSFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKgakkcSEYYATKE
|.   . .. .|||      .| ||| |..      || | ||     .  .| .| || .|  ||| | |.  |. . .|  . |.      ||.   |
mkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse

KpeLVFHEKDqkITVKYEASGTVKFVKP
   | ..|.|  |||        | .| 
p..lewyeed..itvtltdrdefknika
0040439 (Phosphotyrosine protein) phosphatases II 68-316 4.6e-64 211.7 In-house 4-247 (249) alignment 
Range on Protein: 68-316
Range on HMM: 4-247/249.0
QSFKKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATk
  ...  ...||||.|. ..|..|||| . |  ...|||.|......   .|||..|.||..|..||| |. ......| ||..|.|.| .|| .|. . 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

eKPELVFhekdQKITVKYEASGTvkfvkptKAVVKETVLIIEG-PGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARP------LKGPIAVHCSAGI
 . .|..     ..||..    .       |. .. ..| ..    |.... .|....|||| ||||   ...... ..|        .||..||||||.
.ggsley....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGv

GRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
|||| .... .|.|||   ...   . .....|.||....|...|| |...... ..|
gRtGtfiaaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelll
0037934 (Phosphotyrosine protein) phosphatases II 68-314 3.2e-58 192.5 In-house 3-241 (243) alignment 
Range on Protein: 68-314
Range on HMM: 3-241/243.0
QSFKKAQDHHKNRYKDVGCLDNNRVKLahPPwpHDYIHANFVSTPanaKRFICAQAPLDNTCAD----FWYMCLQERVEAIFMLCNLMEKGAKKCSEYYA
  ... ....||||.|. ..|..||||  ..  .|||.||..  .   .|.|. |.||..|..|    || |. ......| ||..|.|.|..|| .|. 
siallpenlsknrysdilpydhsrvkl..eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

tkekPELVFHEkdqkITVKYEASGTvkfvkPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKAR------------PLKGPIA
     | ....    .||..  . .       . .| . .|   .......  .|||.. ||| |||.   .....| ..|            . .||..
....gevtygd....ftvtllseeh.....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSAGIGRTGSVVMIEYMCEQLlngNqiEETDKILQKIREQRNN-SIQTDHQYLFVHQVMMNF
||||||.|||| .... .|...|   .     .......||||.. ..|| .|| |...... .
VHCsaGvgRtGtliaaylmllll...g..vdleeavkllreqRpgkavqtpsqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 69-314 2.7e-62 205.7 In-house 3-242 (245) alignment 
Range on Protein: 69-314
Range on HMM: 3-242/245.0
SFKKAQDHHKNRYKDVGCLDNNRVKLAHPPWP--HDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATke
....  ...||||.|. ..|..|||| ....   .|||.|..|...   ..||..|.||..|..||| |. ......|.||....|.| .|| .|. .  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

KPELVFHEkdqkITVKYEASGTvkfvkptKAVVKETVLIIEG-PGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARP-----LKGPIAVHCSAGIGR
. .|....    .||..    .       .. .. ..| ..  . ..... .|||...||| |||. . .....|  .|       .||..||||||.||
gesltygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgR

TGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
|| .... .|.|||     .   .......|.|| ...||..|| |........
tGtfiaaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 70-315 1.3e-49 163.6 In-house 15-264 (270) alignment 
Range on Protein: 70-315
Range on HMM: 15-264/270.0
FKKAQDHHKNRYKDVGCLDNNRVKLAHPPW--PHDYIHANFVS-TPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATke
 . |.... |||.|.    . ||.|..        || ||.|     . |..|.|..||..|  .|| | ..|.|.|| |. .|.||| |||. |...  
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa..

kpelvfhEKDQKITVKYEASGTVKFVKPTKAVVKETVLIIEgPGGQVLKTTHYHWIDWPDRGVPPADL------SIIELLIKAR-----PLKG-PIAVHC
       |...|.....    ...  .  .     | | .|   |.  . .|... .|||.|||...       .....| . |       |. |. |||
.......epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGIGRTGSVVMIEYMCeQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFF
|||.|||| ........ .||. ..  .. .|....|..| . .|. .|| |........ 
saGvgRtGtlialDiav.rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_ptpA1_pd Subfamily ptpA1 70-273 6.7e-23 76.1 In-house 42-255 (418) alignment 
Range on Protein: 70-273
Range on HMM: 42-255/418.0
FKKAQDHHKNRYKDVGCLDNNRVKLAH--PPWPHDYIHANFVSTpANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEK
  | ..  |||| ..  ..  ||.| .       ||| ||..   |  |.|||.| || || |||| |  ..|.  | ||    |.   ||  |.  .  
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

PE-LVFHEKDQKITVKYEASGTVKFVKPTKAVVKETV-LIIEgpgGQVLKTTHYHWIDWPDRGVPPADLSIIELL----------IKARPLKGPIAVHCS
 | .  . . ...   |          | . ..   . | .|   |.    |.|..  |||. .|     . .||          | .   . || ||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfe...getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGIGRTGSVVMIEYMCEQ
||.||||...    | ..
agvgrtgtfctavimmkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 71-314 5.1e-44 145.4 In-house 5-241 (250) alignment 
Range on Protein: 71-314
Range on HMM: 5-241/250.0
KKAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKkCSEYYATKEkP
|| |...|||| |.  ||. || | .       ||| | |. .  . | || .|.|| .|  ||| | |.| ...| || || |.. . ...|. ... .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.a

elvfhEKDQKITVKYEASGTvkfvkptKAVVKETVLIIEGP-GGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARP---L--KGPIAVHCSAGIGRTG
     ||  ..||.   . .       .| .. ..|..      .     ..|.. |||.|||    ...||| | .       ..|. |.||||.||.|
.....ekyGdvtvsllskee.......fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

SVVMIEYMCEQLLNGNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
. . |. . |.| . ... .  |.....|..| ..... .|| ||.......
afiaidavlerlkkekvv.dvfkvikvlrkdrphavesleqyvfvyeiilka
0049772 (Phosphotyrosine protein) phosphatases II 71-321 9.7e-37 122.7 In-house 42-286 (314) alignment 
Range on Protein: 71-321
Range on HMM: 42-286/314.0
KKAQDHHKNRYKDVGCLDnNRVKLAHPP-WPHDYIHANFVSTPanaKRFICAQAPLDNTCADF----------WYMCL--QERVEAIFM-----------
..   ..||||.|. . | |||.|   |   .|||.|..|...   ..||..|.||..|. ||          | | |  . .|  | |           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCNLMEKGakkcseyyatkekP--------ELVfhekdqkitvkyeasgtvkfvkptkA-------VvketvliiegpggqvLKT-THYH
          |..|...|             .        .|                                  .                ..  .|.
rLdaAlgKtpllildgng.............neptaadlellk.........................eelydpelf...............erlgikyl

WIDWPDRGVPPADL--SIIELLIKArPLKGPIAVHCSAGIGRTGS-VVMIEYMCEQllngnQIeETDKILQKIREQRN-----NSIQTDHQYLFVHQVMM
.|..|| ..|. .   ...|.. .| . .||..|||.||.||||. ||.   |  .     ..   ...|. .|..|      ..|..  ||.|......
ripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gv.sleealedvrlkRpinpnpgfieqleqyefileall

NFFLEKKLF
...  .| |
eylkflkkf
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 71-311 1.3e-28 94.8 In-house 4-237 (239) alignment 
Range on Protein: 71-311
Range on HMM: 4-237/239.0
KKAQDHHKNRYKDVGCLDNNRVKLAHP-PWPH-DYIHANFVST-PANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYatkek
||  .. |||| ..   | .|| | .    || ||| |...     . | .|..|  .  .. ||| |  |||   | ||  |.|   ||| .|.     
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqyw.....

PELVFHEKDQKITVKYeasgTVKFvkpTKAVVKETVLIIEGPGgQVLKTTHYHWIDWPDRGVPPADLSIIELLIK----ARPLKGPIAVHCSAGIGRTGS
|.   .  . ..|..     |  |   .  ...  |.   |   .     .||.  |||.|||    ... |  |    . |   |  .|||||.||||.
pdstskycnlrvtlrk....tevf...adyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVM
...|. |  |  . . ..   . .. |||.|   .||  ||.|.|  .
flvidamlrqakkqktvdif.nyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 71-312 1.4e-28 94.7 In-house 3-237 (239) alignment 
Range on Protein: 71-312
Range on HMM: 3-237/239.0
KKAQDHHKNRYKDVGCLDNNRVKLAHP-PWPH-DYIHANFVST-PANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYatkek
||  .. |||| ..   | .|| | .    || ||| |...     . | .|..|  .  .. ||| |  |||   | ||  |.|   ||| .|.     
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqyw.....

PELVFHEKDQKITVKYeasgTVKFvkpTKAVVKETVLIIEGPGgQVLKTTHYHWIDWPDRGVPPADLSIIELLIK----ARPLKGPIAVHCSAGIGRTGS
|.   .  . ..|..     |  |   .  ...  |.   |   .     .||.  |||.|||    ... |  |    . |   |  .|||||.||||.
pdstskycnlrvtlrk....tevf...adyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMM
...|. |  |  . . ..   . .. |||.|   .||  ||.|.|  ..
flvidamlrqakkqktvdif.nyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 71-147 1.2e-06 22.4 In-house 33-116 (347) alignment 
Range on Protein: 71-147
Range on HMM: 33-116/347.0
KKAQDHHKNRYKDVGCLDNNRVKLA-------HPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFML
.  ..  ||| |||   |. || |.       .   .. || |  .      | .| .| || .|  ||| |    .|  .  .
ewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 72-336 2.1e-38 127.4 In-house 22-271 (284) alignment 
Range on Protein: 72-336
Range on HMM: 22-271/284.0
KAQDHHKNRYKDVGCLDNNRVKLAHPP--WPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCnlmekgAKKCSEYYATKEkpe
  |.  |||. ..   |.|.||| .       ||| | |..   . ...| .| ||||| |||| |  . .. .| .|        .|||.|.  |    
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki...

lVFHEKDQKITVKY--EASGtvkfvkptkAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPL------KGPIAVHCSAGIGRT
 | .|.  |. |.   |..           ||..  |  .|   .. | . .|.  ||| |||     .. |. | | |      . .| ||||||.|||
.vikeerfkvkvdsveesee.........yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMmnffLEKKLFDEeVKKAHADFTHKY
|  .... . ... . .|..   ......|.|||. .|   || |..  .    ||..||      | .||   .
gvyivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysal....leehlfgh.sdvalpdfpayl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 72-313 2.8e-35 116.6 In-house 45-277 (439) alignment 
Range on Protein: 72-313
Range on HMM: 45-277/439.0
KAQDHHKNRYKDVGCLDNNRVKL-AHPPWPH-DYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAkkcseYYATKEKPE
.  |. |||||||| .|  || |   |  ||  || ||..    . | .| .|.| ..|. ||| . .....  | ||.||.|        |. ....  
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevc

--LVFHEKDQKITV-KYEASGTVKFVKPTKAVVKETVLiiegpggqvlkttHYHWIDWPDRGVPPADLSIIELL--I---KARPLKGPIAVHCSAGIGRT
   .    |..| . .|   |   | .  ..  . |||             ..|.| |||. ||     ....|  |   . .   ||. ||||||.|||
ygdiavrvdrnielpnyvirgfkvfnerdttekertvl.............qfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

GSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMN
|... ..   |||   |...  . |.. .|.||.. .|.  ||.|... ...
Gtiialdialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 74-316 2.2e-39 129.9 In-house 42-277 (515) alignment 
Range on Protein: 74-316
Range on HMM: 42-277/515.0
QDHHKNRYKDVGCLDNNRVKL--AHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELV
 ...|||||..  .|..||||   .    .||. | .. .  | | .|..|.|.. .  ||| . |||.| .| |. .| |    ||..|.  |    . 
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

FHEKDqKITVKYEASGtvkfvkptkAVVKETVLIIEGPGgqVLKTTHYHWIDWPDRGVPPADLSIIELLI--KAR--PLKGPIAVHCSAGIGRTGSVVMI
| .     .|  || .           .| .. .. |    .   | .|. .|||.|||.   |.. |.   ||    .. |. .|||||.|||| |. |
fGsik.velvsleact.........ggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisi

EYMCEQLLNGNQIEeTDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
. .  .  ... ..   .....||..|   .||. || |....... .|
dsvvahakttrmvd.vfnfvtnirqkrpylvqtqeqyafiygavledll
0041856 (Phosphotyrosine protein) phosphatases II 75-319 4.8e-46 152.0 In-house 1-175 (182) alignment 
Range on Protein: 75-319
Range on HMM: 1-175/182.0
DHHKNRYKDVGCLDNNRvklahppwPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCnlmekgakkCSEYYATKEkpelvfhe
...||||.|. . |..|        . |||.||..  .  |.|||..|.||..|.|||. |  .... .| .|.         .  |.....        
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell........

kdqkitvkyeasgtvkfvkptkavvketvliiegpggqVLKTTHYHWIDWPDRGVPPaDLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQl
                                          ..|... ||| |||.   ...... ...  .||..||||||.||||..|.. .|... 
......................................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.

lngnQiEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKK
    .    ..... .|..|.....| .|| |...... ..| ||
....g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 75-312 8.7e-37 121.6 In-house 3-236 (237) alignment 
Range on Protein: 75-312
Range on HMM: 3-236/237.0
DHHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVST-PANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELvFH
.. |||| .. . | .|| |  .    ||| |...       |..|.|| ||...| ||| |  ||.   | ||  |.|.  .|| .|.   ..|.  . 
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa.yg

EKDQKITVKYEAS-GTVKFVKPTKAVVKEtvliiegpggQVLKTTHYHWIDWPDRGVPPADLSIIEL---LIKARPL---KGPIAVHCSAGIGRTGSVVM
     .. | | |  ||. .  .| . ..          .|     |..  |||||||    ... .   .|.  |     ||  .|||||.|||| ...
vltvslkkkeefsdytvrslllskrltlk..........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

IEYMCEQLLNgNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMM
|. |  |  . ... .  . .. | |.|   |||  ||.|.||...
idamlrqake.kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 75-338 5e-33 109.5 In-house 18-285 (290) alignment 
Range on Protein: 75-338
Range on HMM: 18-285/290.0
DHHKNRYKDVGCLDNNRVKLAH--PPWPHDYIHANFVSTPANaKRFICAQAPLDNT-------CADFWYMCLQERVEAIFMLCNLMEKGAK----KCSEY
 |....  .|  . ..|| |         ||||||.|. | .  |.|  |.|. ..         .||.|  ||.|. . |||. .|| |.     |..|
khemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

YATKEKPELVFHEkdqkITVKYeasgtVKFVKptKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLKGPIAVHCSAGIGRT
. ...  || |.     .|||       . .|  .  |..  |...  ... .. ||.   .| .. |..  .....|. | .  | |. |||  || | 
vpesvgeelkfkg....ltvkC.....kskek..eddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrs

GSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQV-MMNFFLEKKLFDEEVKK--AHADFTHKYEK
  .  |.  .  . . ..  .. ..|...|.||.. |...... ||  . .. .. ... | || ..  |.|. .. |.|
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeeketykk
Y_phosphatase Protein-tyrosine phosphatase 76-313 1e-70 233.2 Pfam-A 2-235 (235) alignment 
Range on Protein: 76-313
Range on HMM: 2-235/235.0
HHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEk
..||||||. . |..|||| . . |.|||.||.|..  . |.||..|.||..|..||| |..||.|..|.||..|.||| .||..|. ..|. .| ... 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd.

dQKITVKyeasgtVKFVKPTKAVVKETVLIIEGPGG-QVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLK----GPIAVHCSAGIGRTGSVVMIEYM
  |...|      .|  . .|... ... . .  .  .  .....|. .|||.|||    |...|. | .  |    ||. ||||||.||||..|.....
.ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

CEQLLNGNQiEETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
.||| ....  .  .|....|.||....|. .|| |.......
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 76-313 1e-70 233.2 In-house 2-235 (235) alignment 
Range on Protein: 76-313
Range on HMM: 2-235/235.0
HHKNRYKDVGCLDNNRVKLAHPPWPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEk
..||||||. . |..|||| . . |.|||.||.|..  . |.||..|.||..|..||| |..||.|..|.||..|.||| .||..|. ..|. .| ... 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd.

dQKITVKyeasgtVKFVKPTKAVVKETVLIIEGPGG-QVLKTTHYHWIDWPDRGVPPADLSIIELLIKARPLK----GPIAVHCSAGIGRTGSVVMIEYM
  |...|      .|  . .|... ... . .  .  .  .....|. .|||.|||    |...|. | .  |    ||. ||||||.||||..|.....
.ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

CEQLLNGNQiEETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
.||| ....  .  .|....|.||....|. .|| |.......
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 77-319 2.9e-40 133.0 In-house 37-274 (285) alignment 
Range on Protein: 77-319
Range on HMM: 37-274/285.0
HKNRYKDVGCLDNNRVKLAHppWPHDYIHANFVSTPANA-KRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEK
  ||| || |... || |      .|||||...  | .    .| .| || .| .|||.|  ||..  ..||| |.| | .||. ||  |    . | . 
dlnryadvrcieetrvvlkn..hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

DQKITV-KYEAsgtvkfVKPTkAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELL---IKARPLKGPIAVHCSAGIGRTGSVVMIEYMC
.  .|  | ||      .  |  .   ||.  |    . |   | .   |||.  |     .|||     |  | . ||.||||||.||| ..| |.|  
eitlteckeea......iagt.ilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat

EQLLNGNQIEETDkILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKK
 ....  .||  | |....|  | ...|.  |.||.. |.|..|. . 
irimenpniemld.ivremramrfqavqshmqflflyvvlmeyfigeg
subfamily_CG42327_pd Subfamily CG42327 78-244 4.5e-21 69.8 In-house 31-191 (319) alignment 
Range on Protein: 78-244
Range on HMM: 31-191/319.0
KNRYKDVGCLDNNRVKLAHPPW-P-HDYIHANFVSTPANAK-RFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHE
|.|. .|  | . || | . .  .   |..|..|  . .|.  .|.||..|... .||| .  . .   |  |..| |.| |.|.||. |||  .     
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

KDQKITVKYEASGTVKFVkptkavvkETVLIIEGPGGQVLKTTHYHWiDWPDRGVPPADLSIIELLIKAR
 | ..|.|  ...   ..         |.|. .  . .  . ||| . .|.. .||  . ..| .|...|
Gdilvtlkgrevkdryai........stlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
0044763 (Phosphotyrosine protein) phosphatases II 87-317 2.3e-31 104.2 In-house 2-173 (178) alignment 
Range on Protein: 87-317
Range on HMM: 2-173/178.0
LDNNRVKLAHPPW--PHDYIHANFVSTPanakRFICAQAPldntcADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKpelvfhekdqkitvkye
||..||.| ....    |||.|...        ..... |     ||.. .  .. . .| .|.. .| |  || .|. ...                  
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

asgtvkfvkptkavvketvliiegpggqvlktTHYHWIDWPDRGVPP---ADLSIIELLIKAR-PLKGPIAVHCSAGIGRTGSVVMIEYMCEQllngnQI
                                 .|..| .|| |||.     | ..|.. .|. . .||..||||||.||.|..|.. .|...     ..
................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl

eETDKILQKIREQRNnSIQTDHQYLFVHQVMMNFFLE
   ..... .||.|.  .....|. ..... . .. |
.sleeaielvrerRp.ivpnpgqlrqLyefelrllke
0046846 (Phosphotyrosine protein) phosphatases II 91-314 9.9e-42 138.0 In-house 2-172 (176) alignment 
Range on Protein: 91-314
Range on HMM: 2-172/176.0
RVKLAHPPWPHDYIHANFVSTPanakRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELvfhekdqkitvkyeasgtvk
|..| ..... |||.||.. ..    |.|. |.|| .|.|||. | ......|...|....|.|  ||  |.   ||...                    
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

fvkptkavvketvliiegpggqvlkttHYHWIDWPDRGVPPAD--LSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEqllngNQIEETDKILQ
                           .|....||| |||. .  |...|.. .|.  .||..||||||||||| .|..  ..      ..    ...|.
...........................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveeala

KIREQRN-NSIQTDHQYLFVHQVMMNF
..||||  ...||..|| |...... .
lvreqRplgavqtpeQyrflyefelll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 92-193 6.5e-08 26.9 In-house 10-96 (130) alignment 
Range on Protein: 92-193
Range on HMM: 10-96/130.0
VKlahppwPHDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKgakkcSEYYATKEKpeLVFHEKDqkITVKYEASGTVKF
..       ..||.|.||    ... .. .|.|| .|. ||| | |.  |. . .|  . |.      ||.   |   | ..|.|  |.|       .|.
lq......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdseP..lewyeed..iivtltdrdefkn

VK
.|
ik
0043147 (Phosphotyrosine protein) phosphatases II 101-309 4.6e-39 129.2 In-house 5-155 (172) alignment 
Range on Protein: 101-309
Range on HMM: 5-155/172.0
HDYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLmekgakkcseyyatkekpelvfhekdqkitvkyeasgtvkfvkptkavvk
.|||.|......   .|||. |.||.||.|||| |. .. . .|..|..|                                                  
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

etvliIEGPGGQVLKTTHYHWIDWPDRGVPPAD--LSIIELLIK--ARPLKGPIAVHCSAGIGRTGSVVMIEYMCeqllN-GnqieETDKILQKIREQRN
        | . .    .|... ||| |||...  |...|.. .  |.  .||..||||||.|||| .|.. .|.             ..... .||.|.
.....lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl....sleeavalvrekRp

NSIQTDHQYLFVHQ
...|...|| |...
gavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 101-309 3e-38 126.6 In-house 2-164 (174) alignment 
Range on Protein: 101-309
Range on HMM: 2-164/174.0
HDYIHANFVSTPANAKRFICAQAPLDntcadFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATkekpelvfhekdqkitvkyeasgtvkfvkptkavvk
.|||.|....     .|.|. |.||.     ||.|. ........||....|.|  ||  |. .                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

etvliieGPGGQVLKTTHYHWIDWPDRGVPPADLsIIELLIKARPL-----KGPIAVHCSAGIGRTGSVVMIEYMCEQLLngNQIEETDKILQKIREQRN
        .   .    .|... |||.|||. .  ..|..  ..       .||..||||||.|||| .|.. .|. .||  .  ..  ......| || 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp

NSIQTDHQYLFVHQ
...||..|| |...
gmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 101-310 6.7e-28 92.6 In-house 3-148 (151) alignment 
Range on Protein: 101-310
Range on HMM: 3-148/151.0
HDYIHANFVSTPanakrFICAQAPLDntcaDFWYMCLQERVEAIFMLCNLMEKGakKCSEYYATKEkpelvfhekdqkitvkyeasgtvkfvkptkavvk
 |||....|        ... ..||.    ||. .  .. . .|..|....| |  .| ||.   .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

etvliiegpggqvLKTTHYHWIDWPDRGVPPADLSIIELLIKARPL-KGPIAVHCSAGIGRTGSVVMIEYMCEQllngnqiEETDKILQKIREQRNNSIQ
             .. .|....|||| |.|    ...|.| ...   .||..||||||.|||| .|..  |...          ...|. .|..| ...|
.............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq

TDHQYLFVHQV
.  |.||....
pnqqflfqlfa
0051429 (Phosphotyrosine protein) phosphatases II 102-332 1.8e-45 151.0 In-house 5-242 (272) alignment 
Range on Protein: 102-332
Range on HMM: 5-242/272.0
DYIHANFVSTPAN---AKRFICAQAPLDNTCADFWYMcLQERVEAIFMLCNLMEKGAKKCSEYYatkekpelvfH-----------EKDQKITVKYEASG
.||.|..|... .    .|......||..|.||||..  .... .|..|....|.|. ||. |           .           . .. |.. .    
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw..........pgirylhlpilddsaptilygalrvt

TVKFVKPTKAVVKETVLIIEGPGGQVLKTTHYHWIDWPDRGVP-PADLSIIELLIKarplKGPIAVHCSAGIGRTGSVVMIEYMCeQLLNGNQIEE----
.....  .  .. | .|... . |.... .|.|..||||.|||  | |...||| .    .||. ||||||..||| ||.. ..  . .. ..| .    
llseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYll

----TDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKLFDEEVKKAHADF
     .......|.|| ...||..||||......... .    ..|. .|. |.
tnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaalda
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 106-318 2e-08 27.3 In-house 106-312 (346) alignment 
Range on Protein: 106-318
Range on HMM: 106-312/346.0
ANFVSTPANaKRFICAQAPL-DN--TCADFWYMCLQERVEAIFMLCNlmEKGAKKCSEYYATKEKPELVFHEKDQKITVKYEASGTVKfvkptKAVVkEt
  ||    . ...| || |  .|     |||||  ||... ....    .   |. .      |.    .  |      . . ||  |     .  . | 
lyfvifqfe.hklivaqlpqmenesfvedfwymiyqeqihlvylmvp..ddklkntttslfndenggyqytgkmfinnrradvsgdpk.....eyti.e.

vLIIEGPGGQVLKTTHYHwIDWPDRGVPPADLSIIELLIKARPL----KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEeTDKILQKIREQRNNSI
 .. ||    |.   |.|   |     ||  | || .. .        .  . |    | ||. | .   |  .|| || . .   .|...|..||  ..
.vlpegnsdsvicqvhhh.apwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepn.iceimknikqqrpggv

QTDHQYLFVHQVMMNFFLEK
..  ||  .. .....   |
esfaqyasiyaivfdyiark
0049260 (Phosphotyrosine protein) phosphatases II 112-309 8.1e-36 118.4 In-house 5-144 (152) alignment 
Range on Protein: 112-309
Range on HMM: 5-144/152.0
PANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYatkekpelvfhekdqkitvkyeasgtvkfvkptkavvketvliiegpgg
 |. ..||..|.|..||.|||| |  .  . .| ||..|.|.|  || .|.                                                 
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................

qvlkttHYHWIDWPDRGVPPADLSIIELLIK----ARPLKGPIAVHCSAGIGRTGSVVMIEYMCeqllngnQIEETDKILQKIREQRNNSIQTDHQYLFV
      .|... ||| |||. .  ...||.     |.  .||..||||||.|||| .|.. .|.       .  . ..... .||.|...... .|. |.
......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfl

HQ
..
ye
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 115-310 1.9e-07 25.5 In-house 3-198 (198) alignment 
Range on Protein: 115-310
Range on HMM: 3-198/198.0
AKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPElvfhEKDQKITVKYEASGTvkfvKPTKAVvkeTVLIIE---GPGG
 .|.|..| || .| |||| |  .     | |. .   .     . |..| |        |   ..|  ..  |    ||  ..   |.||.        
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt....gkygslsvttktitt....kpdyti...taliltnnttapp

QVLKTTHYHWIDWPDRGVPPADLSIiELLIKARPL--------KGPIAVHCSAGIGRTGSVVMIEYMCEQLLN-GNQIEETDKILQKIREQRNNSIQTDH
   . .|| .  | ..  |   | .  ... .| .          |. |||| | | ||  | ..       .    . .  .. ...|. |   | . .
streishyqftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QYLFVHQV
.| |..||
hynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 115-310 2e-07 25.4 In-house 4-199 (199) alignment 
Range on Protein: 115-310
Range on HMM: 4-199/199.0
AKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPElvfhEKDQKITVKYEASGTvkfvKPTKAVvkeTVLIIE---GPGG
 .|.|..| || .| |||| |  .     | |. .   .     . |..| |        |   ..|  ..  |    ||  ..   |.||.        
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt....gkygslsvttktitt....kpdyti...taliltnnttapp

QVLKTTHYHWIDWPDRGVPPADLSIiELLIKARPL--------KGPIAVHCSAGIGRTGSVVMIEYMCEQLLN-GNQIEETDKILQKIREQRNNSIQTDH
   . .|| .  | ..  |   | .  ... .| .          |. |||| | | ||  | ..       .    . .  .. ...|. |   | . .
streishyqftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QYLFVHQV
.| |..||
hynfiyqv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 116-164 2.6e-06 21.0 In-house 236-281 (440) alignment 
Range on Protein: 116-164
Range on HMM: 236-281/440.0
KRFICAQAPLDNTCADFWYMCLQERVEAIFMLCNLMEkgaKKCSEYYAT
. ||..| ||| |  ||| .  . |. .| || .| .   | || |.  
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 122-318 1.7e-23 77.5 In-house 97-291 (302) alignment 
Range on Protein: 122-318
Range on HMM: 97-291/302.0
QAPLDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEKDQKiTVKYEASgTVKFVKPTKAVVKeTVLIIEGPGG-QVLKTT-HY
  |  .|.  .| .  | .|  .  ||...|.. |||.|||..| . || | .   | ||. .     .|    ....  || | .     .| ||    
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvk.tvsvktd.leeftdkksfkly.tveiknekkkkkvkktvdil

HWIDWPDRGVPPADLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCeQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEK
..  ||| | |    . ...|      |  . ||||||.||||..| | |   ||   ... .  .|.. .|. |  ..|...| ...  ..   ..||
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek
subfamily_hpo-7_pd Subfamily hpo-7 125-324 2e-20 67.8 In-house 43-236 (263) alignment 
Range on Protein: 125-324
Range on HMM: 43-236/263.0
LDNTCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEKDQKITVKYEasgtvkfvkptkAVVKETVLI---IEGpGGQVLKTTHYHW
| .| . |. .  | . | . |||.  |.| .|||.|. ..    ..... .   |   .             |.. |  .   ..    .. . .|| .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs............dvllktlellstlge.Kkkthtvkhysy

IDWPDRGVPPADLSIIELLIKARPLKgPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETD-----KILQKIREQRNNSIQTDHQYLFVHQVMMNFFL
  |...  |    .|...|  || .| .. ||||.||||. . ...| .  ...   .  .|      ..|...|..|. .|.|  |  |   ....|.|
kgWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl

EKKLFDEE
.    .| 
nnfakgel
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 128-335 2.3e-23 77.6 In-house 40-241 (255) alignment 
Range on Protein: 128-335
Range on HMM: 40-241/255.0
TCADFWYMCLQERVEAIFMLCNLMEKGAKKCSEYYATKEKPELVFHEKDQKITVkyeasgtvkfvkPTKAVVKETVLIIEGPG--GQVLKTTHYHWIDWP
| . |. .  | . | . |||.. |.| .|||.|. ..    |.... .   |             ..  ||  |. |.   |   .  . .||..  |.
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk............ssadvvlrtleitstlgekkkthtvkhysykGWi

DRGVPPADLSIIELLIKARPLkGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETD-----KILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKKL
..  |     | ..|  .|    .. ||||.||||. . |..|..  ...   .  ||      ..|...|..|. .|.|  |  |   ......  |. 
eknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkge

FDEEVKKAHADFTHK
.... .. .  . | 
leakyqeirksylha
0048076 (Phosphotyrosine protein) phosphatases II 213-312 1.3e-22 75.4 In-house 44-140 (145) alignment 
Range on Protein: 213-312
Range on HMM: 44-140/145.0
VLKTTHYHWIDWPDRGVPPA---DLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEqllngNQiEETDKILQKIREQRNNSIQTDHQYLFVHQ
. . ..|....|||.|||.     |...|.. .|.. .||..||||||.||||..|..  | .     ..    ...|...|.|| .......|. |...
erlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrpgavpnpgqlrflye

VMM
. .
fel
PTPc_DSPc_SM00012 216-312 6.8e-29 95.5 In-house 2-104 (105) alignment 
Range on Protein: 216-312
Range on HMM: 2-104/105.0
TTHYHWIDWPDRGVPPADLSIIELLIKARPLKG------PIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQ
 .|||. .||| |||    ||.||| . .  |       |. ||||||.|||| .|.......|| ....  .  .|....|.||....||..||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VMM
...
all
0048179 (Phosphotyrosine protein) phosphatases II 216-309 4e-21 70.7 In-house 49-139 (144) alignment 
Range on Protein: 216-309
Range on HMM: 49-139/144.0
TTHYHWIDWPDRGVPPA---DLSIIELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCeqlLNGnqiEETDKILQKIREQRNNSIQTDHQYLFVHQ
 ..|....|||.|||.     |...|.. .|.. .||..||||||.||||..|..  |    ..|      ...|. .|..| .......|. |...
giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klg...lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 217-316 7e-14 46.0 In-house 92-195 (440) alignment 
Range on Protein: 217-316
Range on HMM: 92-195/440.0
THYHWIDWPDRGVPPADLSIIELLIK-----ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVM
 .||.  |||.|||     .....        .  .||. |||||| |||| .. .. .  .    .||.    ... .|..| . .|| .|| |||...
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyafvheav

MNFFL
.. .|
legll
0038934 (Phosphotyrosine protein) phosphatases II 217-309 9e-11 37.3 In-house 80-171 (194) alignment 
Range on Protein: 217-309
Range on HMM: 80-171/194.0
THYHWIDWPDRGVPPaDLSIIELLIK------ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLngnqieETDKILQKIREQRNNSIQTDHQYLFVHQ
 .|. . .||.|..| .|.|.   ..      ..  .| .|||| ||.|||| .|    .. . .        .. .. .|| |...|.. ...  ...
ieylklpfpddgtvP.sleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleallk
PTEN_1 218-307 4.5e-09 31.4 In-house 96-185 (196) alignment 
Range on Protein: 218-307
Range on HMM: 96-185/196.0
HYHWIDWPDRGVPPADLSI--IELLIKARPL---KGPIAVHCSAGIGRTGSVVmieymCEQLLNGNQiEETDKILQKIREQR-NNSIQTDHQYLFV
 |. ....| |.|. .  .  .. .| .. .   .. ..||| ||.||.| ||     .  |.  ..    |. |. .||.| ...... .|  ..
eylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgk.ltadeAlelvrekRppgapnspsqerll
subfamily_PTPDC1_pd Subfamily PTPDC1 219-313 5.3e-12 40.5 In-house 85-174 (182) alignment 
Range on Protein: 219-313
Range on HMM: 85-174/182.0
YHWIDWPDRGVPPAD--LSIIELLIKArPLKGPIAVHCSAGIGRTGSVVMIEYMCEqllngNQIeETDKILQKIREQRNNSIQTDHQYLFVHQVMMN
.. . |.| ||.. .  | |. ..  |   .| .|||| || |||| ..    .       ... ...| ....|..| .|||| .|  .|.. .. 
vynfgwkDygvasleriLdivkvvafa.lqegkvavhChaGlGrtGvliacylvya.....krl.taekaiklvrskrpksiqtreqvelvkefalf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 220-329 9.2e-12 39.0 In-house 187-298 (302) alignment 
Range on Protein: 220-329
Range on HMM: 187-298/302.0
HWIDWPDRGVPPADLSIIELLI----KARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGnQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMmNFF
.   |..  ||    ..|.       |  . . ....    |.|| |...      |.| .| .  .   |...||.|| ..... .|| ... .. ...
vltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyial.lly

LEKKLFDEEVKKAH
. ||. ..|.||  
ikkkvtkpeekkkk
subfamily_PRL_pd Subfamily PRL 234-306 7.3e-06 20.1 In-house 78-141 (151) alignment 
Range on Protein: 234-306
Range on HMM: 78-141/151.0
LSIIELLIKARPlKGPIAVHCSAGIGRTGSVVMIEYMcEQllnGNQIEetdKILQKIREQRNNSIQTdHQYLF
|....   | .| |  .|||| ||.||.  .| .  . |.   | . |   . .. |||.|...| . .|  |
lellkekfkeep.kstvavhcvaGlGraPvlvalali.ea...Gmkye...davefirekrrgains.kqlkf
subfamily_CDC14_pd Subfamily CDC14 236-310 5.7e-07 23.7 In-house 251-321 (328) alignment 
Range on Protein: 236-310
Range on HMM: 251-321/328.0
IIE-LLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNqieETdkiLQKIREQRNNSI-QTDHQYLFVHQV
|.. .|  |   .| ||||| ||.||||...    | .  .. .   |.   .  .|  |  |.    ...|  .| 
ivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaa...ea...iawlricrPGsvigpqqkfleekqa
subfamily_DSP19_pd Subfamily DSP19 236-296 8.5e-07 23.4 In-house 78-132 (152) alignment 
Range on Protein: 236-296
Range on HMM: 78-132/152.0
IIELLIKARPLKGPIAVHCSAGIGRTGSVVMiEYMCEqllngNQIEETDKILQKIREQRNN
... . .||  .| . |||.||. |. |||.  |. .     ..  .. . |...||.| .
aldFieearskdgavlvHCnAGvSRsasvvi.aylmk.....keelsleealelvrearpc
DSPc Dual specificity phosphatase, catalytic domain 237-292 4.8e-07 24.7 Pfam-A 63-115 (133) alignment 
Range on Protein: 237-292
Range on HMM: 63-115/133.0
IELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLngnQIEETDKILQKIRE
.| . ||.  .. ..||| ||| |......  .|... |   ...|  ..... |.
vefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl...slneAyefvkerrs
DSPc Dual specificity phosphatase, catalytic domain 237-292 4.8e-07 24.7 In-house 63-115 (133) alignment 
Range on Protein: 237-292
Range on HMM: 63-115/133.0
IELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLngnQIEETDKILQKIRE
.| . ||.  .. ..||| ||| |......  .|... |   ...|  ..... |.
vefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknl...slneAyefvkerrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 238-312 8.8e-15 49.3 In-house 219-292 (297) alignment 
Range on Protein: 238-312
Range on HMM: 219-292/297.0
ELLIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNgNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMM
| |  . | . .. ||||||.||.| ||. . . ..| . ..| ..  ||...||||   .|| .|. .......
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrk.kripdvaailsilreqrarlvqtleqfellydavl
PTPc_motif_SM00404 240-299 1e-07 26.9 In-house 73-125 (140) alignment 
Range on Protein: 240-299
Range on HMM: 73-125/140.0
LIKARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNqieETDKILqkiREQRnNSIQ
. .|.  .| . ||| ||. |...... ..|... |. .   |  ...   .|.| ..|.
ienaekkggkvlVHCqaGvSRSatliiaYlmryrqlsla...eayefv...kerR.piis
subfamily_eak_pd Subfamily eak 240-319 6.4e-06 19.8 In-house 230-309 (332) alignment 
Range on Protein: 240-319
Range on HMM: 230-309/332.0
LIKARPLKGPIaVHCSAGIGRTGSVVMIEYMCEqLLNGNQ--IEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKK
 |.. |   || . .. |  |.|  |.|. . . |.....      .... |....|. |. .. |. |.........| ..
yihtppsfapi.iqsarGsaraGvfvvidllir.lidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_DSP23_pd Subfamily DSP23 243-309 4.8e-06 21.3 In-house 80-140 (148) alignment 
Range on Protein: 243-309
Range on HMM: 80-140/148.0
ARPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNgnqieETDKIlQKIREQRNNSIQTDHQYLFVHQ
|   .  ..|||  | ||||...   .. |. |       .. |  ..|..|  |..|  |   |..
aeekneavsvhcllgrgrtgtmlacylvkerkla.....aaeai.aevrrlrpgsvetveqeklvrd
subfamily_PTPN9_pd Subfamily PTPN9 244-319 4e-18 60.5 In-house 220-294 (297) alignment 
Range on Protein: 244-319
Range on HMM: 220-294/297.0
RPLKGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETdKILQKIREQRNNSIQTDHQYLFVHQVMMNFFLEKK
.| . || |||||||||||  . ...  ..| . .... . . ....|.||  ||||..|| | .. .... ||.|
hpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvv.etvkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_CG42327_pd Subfamily CG42327 247-314 1.4e-12 42.0 In-house 247-314 (319) alignment 
Range on Protein: 247-314
Range on HMM: 247-314/319.0
KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNF
.||..|||| |.|||| |.  .   ..| . ..  .  .... .|..| ....| .|| |...|. ..
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 247-307 2.5e-06 21.2 In-house 271-330 (347) alignment 
Range on Protein: 247-307
Range on HMM: 271-330/347.0
KGPIAVHCSAGIGRTGSVVMIEYMCEQLLNGNQiEETDKILQKIREQRNNSIQTDHQYLFV
. |. | |  |. |. .||.   . ||.|.|.   . |....|.|.||   .     | . 
lapvvvmcdlgldrsatvvltsiiieqvldgkt.pdcddlfkkmrdqragvftmsifytya
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 248-315 1.4e-08 28.8 In-house 263-344 (350) alignment 
Range on Protein: 248-315
Range on HMM: 263-344/350.0
GPIAVHCSAGIGRTGSVVMIEYMCEQLLNG-------NQIEE----TD---KILQKIREQRNNSIQTDHQYLFVHQVMMNFF
 || ||||||.|||| .| .... ....         ....      |    |....|.|| . .|. .|..|... ....|
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 248-315 6.2e-06 19.8 In-house 266-344 (349) alignment 
Range on Protein: 248-315
Range on HMM: 266-344/349.0
GPIAVHCSAGIGRTGSVVMIEYMCEqLL-----NGNQIE----ETDKI---LQKIREQRNNSIQTDHQYLFVHQVMMNFF
 .. |||||| |||| .| .... . .|     . |.|.      | |   . ..| || . .|   |. .... ....|
stllvhcsaGcGrtGvlvtldllls.ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_PTEN_pd Subfamily PTEN 250-308 1.7e-06 23.1 In-house 117-173 (184) alignment 
Range on Protein: 250-308
Range on HMM: 117-173/184.0
IAVHCSAGIGRTGSVVmIEYMCEQLLNgNQIEETDKILQKIREQRNNSIQTDHQYLFVH
..||| || |||| .. . |. ..||  .. ||. .. ...| . .....   |  .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve