Gene C43E11.5 in Caenorhabditis elegans

Synonym: CELE_C43E11.5, C43E11.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf2
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP035_AA protein Get Run
CeleP035_AA_28-335 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 27-340 6.9e-34 113.0 In-house 17-305 (308) alignment 
Range on Protein: 27-340
Range on HMM: 17-305/308.0
DTTSTVSEGQSPTEVADQLLKAKSRPQMY------DLLKGHAAFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYVRME----GAEYIIVQAP
......|. .|  ... .| ||... ...        .| .  ..| ....| . |    |.. |. ||  ...  .    ||..       ..|. |.|
tsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgP

TKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTYFPTELE-QKMEAelmkGTLSIVCKAREGlSMGATKYELELTDSEvvidknsddpnasNYK
.... .  || . . ..|. |.|.  ..    .  ||. |.|.||. . .|     | ... ..  |    . |...||||...             . .
lpntvedFwrmvweqnvrvIvmLtklve...ngrekcaqYwplelgggsley....gkftvtllseev.lddytvrtleltnlg.............dge

SHRLIVFHMNTWSgqkptSGNALEQAQNVALFFREVKKFEmdilRKsmenfvPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNG
|... .||. .|       ... .... .  |...|.|.     ..      .|..  . .|..|. |  ....||. .||  ..||....| . . |.|
srtvthfhytnWp.....dhgvPpspeilldflelvrksl....pg......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpg

SISTYYQFCFCMAVCLNIGKDTNWC
.. |. |..|.. ..| . |.  ..
mvqtpeqylflyralleylklkltk
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 28-354 2.8e-243 798.1 In-house 1-327 (327) alignment 
Range on Protein: 28-354
Range on HMM: 1-327/327.0
TTSTVSEGQSPTEVADQLLKAKSRPQMYDLLKGHAAFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYVRMEGAEYIIVQAPTKKSSKLIWRV
||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ttstvsegksptevadqllkaksrpqmydllkghaafnvpefvknlpvnvrlpipirdnrrvlcgsdeeffpgqyvrmegaeyiivqaptkksskliwrv

ILKDHIRILVCLCHDEQMSGSDDGKCYTYFPTELEQKMEAELMKGTLSIVCKAREGLSMGATKYELELTDSEVVIDKNSDDPNASNYKSHRLIVFHMNTW
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsivckareglsmgatkyeleltdsevvidknsddpnasnykshrlivfhmntw

SGQKPTSGNALEQAQNVALFFREVKKFEMDILRKSMENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCM
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
sgqkptsgnaleqaqnvalffrevkkfemdilrksmenfvppvmlqsfdginrastgwvalmllrdvekrecfdvpslikaimkfrngsistyyqfcfcm

AVCLNIGKDTNWCANDCSTALTDLMEK
|||||||||||||||||||||||||||
avclnigkdtnwcandcstaltdlmek
0036941 (Phosphotyrosine protein) phosphatases II 43-348 2.1e-34 114.6 In-house 8-291 (297) alignment 
Range on Protein: 43-348
Range on HMM: 8-291/297.0
DQLLKAKSRPQMYDLLKGHAAFN--VPEFVKNLPVNVRLPIPIRDNRRVLCgSDEE--FFPGQYVRMEG--AEYIIVQAPTKKSSKLIWRVILKDHIRIL
..| .|. . ....||. .. ..  | ....||. |    |.. |. ||   .||.  .. . || . .   ..|. |.|....    || ... .....
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VCLCHDEQMsgsDDGKCYTYFPTELEQKMEAelmkGTLSIVCKAREG-LSMGATKYELELTDSevvidknsddpnaSNYKSHRLIVFHMNTWSgqkptSG
|.|. ....   .  ||. |.|.| .. ..     | ... ..  |  |. . | ..||.||               | .|... .||. .|        
vmltelvel...grekcaqywpleegeslty....gdftvtllsvevvllddytlrtlevtdt.............gngesrtvthfhytgwp.....dh

NALEQAQNVALFFREVKKFEmdilRKSMENfvPPVMLQSFDGINRASTGWVALMLLRDVE---KRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLN
.. | .. .  |...|.|.     ......  .||.  . .|..|. |  .| ..|. .|   |....|.....| ... |.|.. |. |..|.  . |.
gvpespaslldfielvrkvl....kllpsg..gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle

IGKDTNWCANDCSTAL
  | .... .... .|
llkkkltkepllklvl
0039614 (Phosphotyrosine protein) phosphatases II 56-329 1.1e-16 56.7 In-house 40-284 (297) alignment 
Range on Protein: 56-329
Range on HMM: 40-284/297.0
DLLKGHAAFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEF-FPGQYV-----RME---GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMS
.||.    . . ....| . |    |.. |. ||   . ... ..  |.      .    . ..|. |.|.... .  || . . .....|.|.  . ..
ellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg

GsddgKCYTYFPTELEqkmeaelMKGTLSIVCKAREGlSMGATKYELELTDsevviDKnsddpnasnyKSHRLIVFHMNTWSGQKPT-SGNALEQAQNVA
     ||. |.|.| .       . |.... ..  |    | | ..||.|.     ..          .|. . .|.   |   ..  | . | .. . .
r....kcaqywpeegg.......tygdftvtllkveh.ldgytvrtlevtn.....ng..........esrtvthfqytgwpdhgvppslellleflelv

LFFREVKkfemdilrksmeNFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAV
  ...              .   ||   . .|..|. |  .|...|. .||. ..||.. .| . . |.|.. |  |. |.. .
realael............pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0040438 (Phosphotyrosine protein) phosphatases II 63-353 1e-32 109.1 In-house 34-295 (317) alignment 
Range on Protein: 63-353
Range on HMM: 34-295/317.0
AFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYV----------RMEgaeYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGK
 ..| |...| . |    |.. |. ||   .... ..  |.          ...   .|. |.|....    || . . .....|.|.. |.    .. |
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk...fIatqgPlpntvedFwrmvweqgvtvivmLtelee...lgrek

CYTYFPTelEQKMEAelmkGTLSIVCKAREGlSMGATKYELELTDSevvidknsD-DpnasnyKSHRLIVFHMNTWSgqkptSGNALEQAQNVALFFREV
|. |.|.  .....     |.... ..  |    | | ..||..|.        . .      .|... .||. .|       ... .  . .  |...|
caqYwpl..getlty....gdftvtllseee.lagitlrtlevedl........gds......esrtvthfhytgWp.....dhgvppspdllldfleav

KKFEmdilrksmENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLNIGKDTNWCANDCSTALTDL
...         |.   ||.  . .|..|. |  .|...|. .||....||.. .| . ..|.|.. |. |..|.. . |.. | .... .... .|  |
real........edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkll

ME
..
kl
0046845 (Phosphotyrosine protein) phosphatases II 63-340 1.2e-28 95.7 In-house 19-280 (284) alignment 
Range on Protein: 63-340
Range on HMM: 19-280/284.0
AFNVPEFVKNLPVNVRLPIPIRDNRRVLCG------SDEEFFPGQYVRME-------GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSD
 ..|  ...||  |    |.. |. ||         .| ...   ||..          ..|. |.|.... .  ||.... ..|..|.|.  ..    .
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelve...ng

DGKCYTYFPTElEQKMEAelmkGTLSIVCKAREGlSMGATKYELELTDSEVvidknsddpnasNYKSHRLIVFHMNTWSgqkptSGNALEQAQNVALFFR
  ||. |.|.| .....     | ... .. .|    . |...||||. ..            . .|.....||. .|        .. ......  |.|
rekcaqYwple.gevlty....gdftvtllseev.kddytvrtleltnlgy............tgesrtvthfhytswp.....dhgvppspedlleflr

EVKKFEMDilrksmENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRE---CFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLNIGKDTNWC
.|...  .       .  .|..  . .|..|. |  .. .||. .||..   ..||....| . . |.|.. |. |..|.  ..|.  | ....
lvrellen......lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0047943 (Phosphotyrosine protein) phosphatases II 63-331 9.8e-28 92.8 In-house 29-269 (273) alignment 
Range on Protein: 63-331
Range on HMM: 29-269/273.0
AFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSD-EEFFPGQYVRM--EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPT
 ..| ....|.  |    |.. |. ||  |..   .    ||..   . ..|. |.|.... .  || . . ..|..|.|. ....   .  ||. |.|.
tysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvel...grekcaqYwpl

ELEQ-KMEAelmkGTLSIVCKAREGlSMGATKYELELTDSEvvidknsddpnasNYKSHRLIVFHMNTWSgqkptSGNALEQAQNVALFFREVKKFEMDI
| .. ...     | ... ..  |    . |...||||...             . .|.  ..||. .|        .. .. . .  |...|.|.   .
eggelslty....gkftvtllseet.kddytvrtleltnlg.............tgesrtvthfhytgwp.....dhgvppslesllefielvrkaleal

LRKsmenfvPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
 ..      .||.  . .|..|. |  ....||. .||. ..||....| . . | |.. |. |..|.. . |
psn......gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 63-331 1.3e-26 89.4 In-house 46-301 (307) alignment 
Range on Protein: 63-331
Range on HMM: 46-301/307.0
AFNVPEFVKNLPVNVRLPIPIRDNRRVLCGS------DEEFFPGQYVRM----------EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMs
 ... ....| . |    |.. |. ||   |      |  .. . |||.           . ..|. |.|.... .  || . . .....|.|.... . 
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvel.

gsDDGKCYTYFPTElEQKMEAELmkgtLSIVCKAREGlSMGATKYELELTDSevvidknsddpnASNYKSHRLIVFHMNTWSgqkptSGNALEQAQNVAL
  .. ||. |.|.| ..... .     . . ..  |    | | . ||.||.              . .|.....||. .|       ... .  . .  
..grekcaqywPde.geeltygn....ftvtllseeh.ldgytvrtlevtdl............dgtgesrtvthfhytgwp.....dhgvppsfeelld

FFREVKKfemdILRKSMENfvPPVMLQSFDGINRASTGWVALMLLRDVEKREC---FDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
|..||.|    .|... ..   ||.  . .|..|. |  .|...|| .||...   .|... .| . . | |.. .. |..|.. . |
fieevrk....aleelpkg..gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0051299 (Phosphotyrosine protein) phosphatases II 63-330 1.2e-19 66.3 In-house 40-282 (288) alignment 
Range on Protein: 63-330
Range on HMM: 40-282/288.0
AFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYV-----R--MEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYT
 ...  ...||. |    |.  |. ||   . ..  .. |.     .    . ..|. |.|.... .  || . . ..|. |.|.  .     .  ||. 
tlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklve...lgrekcaq

YFPTeleqkmEAELMKGTLSIVCKAREGlSMGATKYELELTDSEVVIdknsddpnaSNYKSHRLIVFHMNTWSGQKPTSgnaleQAQNVALFFREVK---
|.|.      .  |. | ... ..  |    . |...||.|. ...           . .|.. ..||. .|  .   .      .. .  | |.|.   
Ywpl......ggsltygditvtllseev.lddytvrtlevtnldlld.........gdgesrtvthfhytnwpdhgvpd.....spellldflrlvrkal

KfemdilrksmeNFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVC
.           .  .||.  . .|..|. |  ....||. .||....||....| . . |.|.. |  |. |.  . 
a...........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
0043336 (Phosphotyrosine protein) phosphatases II 63-329 7.2e-18 60.5 In-house 36-272 (278) alignment 
Range on Protein: 63-329
Range on HMM: 36-272/278.0
AFNVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYVR-------MEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYT
 ... ....| . |    |.. |. ||   .... ..  |.          . ..|. |.|.... .  || . . .....|.|. ..     .  ||. 
tysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelve...lgrvkcaq

YFPteleqkmEAELMKGTLSIVCKAREGlSMGATKYELELTDsevvidknsddpnASNYKSHRLIVFHMNTWSGQKPTSgnALEQAQNVALFFREVKkfe
|.|       .  |  |.... ..  |    . | . ||.|.               . .|.   ..|   |  ..  .   |.. ..   ..||.    
Ywp.......ggsltygdftvtllkeeh.lddytvrtlevtn.............lgdgesrtvthyhylgwpdhgvpe..slsllldflkavreal...

mdilrksmENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAV
        |.   ||.  . .|..|. |  ....||. .||. ..|... .| . ..| |.. |  |. |.  .
........edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 64-327 5.5e-06 21.8 In-house 38-273 (314) alignment 
Range on Protein: 64-327
Range on HMM: 38-273/314.0
FNVPEFVKNLPVNVRLPIPIRDNRRVL-----CGSDeeFFPGQYVRMEgAEYIIVQAPTKKSSKLI----------WRVIL--KDHIRILVC--------
. |  ...|  .|  | |.  |||..|      |||  ..   ||.     .|. |.|..     .          ||..|  . ..|..|.        
ilvadlflnrdknryldilpadnrvilpglpvsgsd..yinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LCH-DEQMsgsddgkcytyfpteleqkmeaelmkgtlsiV----------CkareglsmgatkyeleltdsevvidknSDDPNASNY
             |.  |...                                          .                           .   ... .
elsrLdaAlgKtpllildgng...............................neptaadlellk...........................eelydpelf

KSHRLIVFHMNTWSGQKPTSGNaleqaqnvalffreVKKFEMDILRKsmeNFVPPVMLQSFDGINRASTGWVALMLLRDVekreCFDVPSLIKAIMKFRN
. . . ....... |. |..                ...|   |..    .   ||     .|..|. | .|| .|..       ...   .. ... | 
erlgikylripvpDgsaplled..............fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp

-----GSISTYYQFCFCM
     |.| .. |..|..
inpnpgfieqleqyefil
0040439 (Phosphotyrosine protein) phosphatases II 65-331 9.1e-27 89.7 In-house 4-243 (249) alignment 
Range on Protein: 65-331
Range on HMM: 4-243/249.0
NVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYVRM-------EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYF
.| ....|.. |    |.. |. ||  .. .. |.. |. .        . ..|. |.|.... .  || . . .|...|.|......   .  ||. |.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvel...grekcaqyw

PTelEQKMEAelmkGTLSIVCKAREGlSMGATKYELELTDSEvvidknsddpnasNYKSHRLIVFHMNTWSgqkptSGNALEQAQNVALFFREVKKFEMD
|.  .. .|     |.... ..  |  . . | ..||||...             . .|..  ....  |        .. .  . .  |...|.|.  .
pl..ggsley....gdftvtllsvev.kddytvrtleltnly.............dgesrtvlhiqytdwp.....dhgvppsfedlldfieavrkalee

IlrksmeNFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
.      .   ||.  . .|..|. |  .|...|. .||. ..|... .| . . |.|.. .. |..|.. . |
l......pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0042113 (Phosphotyrosine protein) phosphatases II 65-329 3.1e-22 74.6 In-house 2-238 (245) alignment 
Range on Protein: 65-329
Range on HMM: 2-238/245.0
NVPEFVKNLPVNVRLPIPIRDNRRVLCGSDEEFFPGQYV--------RMEGAeYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTY
.| ....| . |   .|.. |. ||   .|.. .   |.        |. .  .|. |.|.... .  || . . .|...|.|. .|     .  ||. |
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeee...lgrvkcaqy

FPTelEQKMEAelmkGTLSIVCKAREGlSMGATKYELELTDSevvidknsddpnaSNYKSHRLIVFHMNTWSGQKPTS-GNALEQAqnvalffrevkkfe
.|.  .....     |.... ..  |    . | ..||.|.               ...|.  |..|   | ......  . |...              
wpl..geslty....gdftvtllseeh.lddytvrtlevtnl.............gddesrevihyhylpwpdhgvpdllellldf..............

M--------DilrksmeNFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAV
.        .       .   ||.  . .|..|. |  .|...|. .||. ...... .| . ..| |.. |  |. |.. .
lefvrkalae.......dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0037934 (Phosphotyrosine protein) phosphatases II 67-329 5.9e-14 47.7 In-house 5-237 (243) alignment 
Range on Protein: 67-329
Range on HMM: 5-237/243.0
PEFVKNLPVNVRLPIPIRDNRRVLCgSDEEFFPGQYVRMEGaEYIIVQAPTKKSSKL----IWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPtele
. .. ||. |    |.  |. ||   ... .... .... .  .|. |.|.... .      || . . .|...|.|......   .  ||. |.|    
allpenlsknrysdilpydhsrvkl.egsdyinanliyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvEl...grekcaqywp....

qkmeA-ElMKGTLSIVCKAREGLSMgATKYELELTdsevvidknsddpNAS-NYKSHRLIVFHMNTWSgqkptSGNALEQAQNVALFFREVKKFEMDILR
      . . |.... ..  | |.   | ..|.|.             | . .. ..  | .|   |       ... .  ...  |..||..|  ..| 
....gev.tygdftvtllseehldd.ytvrtllle.............nldlddltrlvihyhylpwp.....dhgvPdspedlldfldevrefieells

KSME--NfvPPVMLQSFDGINRASTGWVALMLLRDVekreCFDVPSLIKAIMKFRNG-SISTYYQFCFCMAV
   .  .   || .    |..|. |  .|...|. .    ..|. . .| . . |.| .. |. |. |.. .
llaldsg..gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 68-330 7.7e-16 53.8 In-house 29-268 (278) alignment 
Range on Protein: 68-330
Range on HMM: 29-268/278.0
EFVKNLPVNVRLPIPIRDNRRVLcgsdeEFFPGQYVRMEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMSGSddgKCYTYFPtElEQKMEA
 ...||. |    |.  |. ||      ..    |... . ..|. |.|...     || . . .|...|.|.. ....     ||. |.| | .. .. 
lylgnldknRykdilpydhsrVk.....dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre...kcaqywp.e.ggslty

elmkGTLSIVCKAREGLsMGATKYELELTDSEVVIDKnsddpnasnYKSHRLIVFHMNTWSGQKPTSGNALEQAQNVALFFREVKKFEMDILRKSM--EN
    | ... ..  | |    |.  |..|.  |             ..|. . ..|. .|    . | . | . ...  | ||. |. .. |. |.  ..
....gdftvtllseevl.ddytlrtllvtnltvered.........lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

FVPPVMLQSFDGINRASTGWVALMLLRDVekRECFDVPSLIKAIMKFRNG-SISTYYQFCFCMAVC
   ||      |..|. |  .| ..|. .   . .|... .| . . |.| .. .  |. |.. . 
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefl
subfamily_PTPN3_pd Subfamily PTPN3 70-330 6.8e-09 30.0 In-house 39-272 (280) alignment 
Range on Protein: 70-330
Range on HMM: 39-272/280.0
VKNLPVNVRLPIPIRDNRRV-LCGSDEEFFPGQYVRMEGAE------YIIVQAPTKKSSKLIWRVILKDHIRILVCLCHdeQMsGSDDGKCYTYFPTELE
 .||. |    |   |. || |  |. ..   .|| ||         ||. | | .|...  |... .......| |    ..  .   ||. |.|.. .
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmltt..lv.erGrvkChqyWPeted

qkmeaELMKGTLSIVCKAReglsmgatKYELELTDSEVVIDKNSddpnasNYKSHRLIVFHMNTWSGQKptsgnALEQAQNVALFFREVKKFEmdilrks
     ||  |..|..|. .        . . .    |.|. ...      . ...... .    |. ..       ......  | ..|.|         
.....eleygefsvkceke........detksyvlrelvlkdke......tkeerkilqlqylaWpdhg.....vPddsadflefvervrklr.......

mENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFC-MAVC
 .    ||..    ||.|.    .  . |  .|..| . .. ... .   |   . |  |. |   |..
.sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
Y_phosphatase Protein-tyrosine phosphatase 78-331 8.4e-35 115.6 Pfam-A 7-234 (235) alignment 
Range on Protein: 78-331
Range on HMM: 7-234/235.0
RLPIPIRDNRRVLC---GSDEEFFPGQYV---RmEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPteleQKMEAELMK
   |.. |. || .   ......   .||   . |  ..|. |.|.|.. .  ||.... .....|.|...|..   .. ||  |.|    ...| .|. 
ykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek...grekcaqYwp....eeeeeslty

GTLSIVCK-AREGLSMGATKYELELTDSEVVIdknsddpnasnyKSHRLIVFHMNTWSGQKPTsgnalEQAQNVALFFREVKKFEmdilrksmENFVPPV
|.... .|   .  . . | ..|||....               ..... ..|...|  ..       |.....  . |.|.| .        |.   ||
gdikvelkekekedekeytlrklelkkkkees............ekrevkqlhytnWpdhgvp.....espkslldlirkveksk........eaksgpv

MLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
. .. .|..|. | ... .||. .|..|..|| ...| . | |.|..... |..|.....|
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 78-331 8.4e-35 115.6 In-house 7-234 (235) alignment 
Range on Protein: 78-331
Range on HMM: 7-234/235.0
RLPIPIRDNRRVLC---GSDEEFFPGQYV---RmEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPteleQKMEAELMK
   |.. |. || .   ......   .||   . |  ..|. |.|.|.. .  ||.... .....|.|...|..   .. ||  |.|    ...| .|. 
ykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek...grekcaqYwp....eeeeeslty

GTLSIVCK-AREGLSMGATKYELELTDSEVVIdknsddpnasnyKSHRLIVFHMNTWSGQKPTsgnalEQAQNVALFFREVKKFEmdilrksmENFVPPV
|.... .|   .  . . | ..|||....               ..... ..|...|  ..       |.....  . |.|.| .        |.   ||
gdikvelkekekedekeytlrklelkkkkees............ekrevkqlhytnWpdhgvp.....espkslldlirkveksk........eaksgpv

MLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
. .. .|..|. | ... .||. .|..|..|| ...| . | |.|..... |..|.....|
vVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 81-339 2.7e-13 44.2 In-house 65-288 (290) alignment 
Range on Protein: 81-339
Range on HMM: 65-288/290.0
IPIRDNRRVLC--GSDEEFFPGQYVRMEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLChdEQMSgSDDGKCYTYFPTELEQKmeaeLMKGTLSIVC
..  |  ||.   | | ..   .||.   | .|. | ..|..   |||..|....  .| ||  | .      ||  |.| .  .     |  | ....|
vvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlc..elie.dGkakceqyypekeGev....ltfGeitvlc

KAREglsmgaTKyeleltDSEvVIDKNSDDPNASNYKSHRLIVFHMNTWSGQkptsgnALEqAQNVALFfREvkkfeMDILRKSmenfVPPVMLQSFDGI
   .      .|      |.. .| |     .  . |.|.|  ... .|  .      ..    ..||. |      . ||||       ||..    ||
seed......dk......dan.iikktlsvrdkdsGkehklkhlkikswpdk......sva.lstlall.rt.....lrilrka....sGpvvvhcsaGi

NRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLNIGKDTNW
 |. |     . |. . .   .|.  |..|. . | .|.    |.   . . |..||| ..
GrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_CG42327_pd Subfamily CG42327 81-180 5.9e-07 23.5 In-house 38-139 (319) alignment 
Range on Protein: 81-180
Range on HMM: 38-139/319.0
IPIRDNRRVL--CGS--DEEFFPGQYVRME---GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsGSDdgKCYTYFPTEleQKMEAELMKGT
.|. . | ||   |.   .|..  .|||      . || .|.. ..||   ||.. .   |..|.|.   .  | .  .|  |.||.  . .. . . | 
vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlsel.Gik..vcaeylPtk..etldntslyGd

LSIVCKA
. .  | 
ilvtlkg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 82-331 8.9e-11 36.3 In-house 58-275 (287) alignment 
Range on Protein: 82-331
Range on HMM: 58-275/287.0
PIRDNRRVLCGSDEEFFPGQYVR--MEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTYFPTEleqkmEAeLMKGTLSIVCK
.  ..| .| | ....    ..    |  ..|| ..|  .  .  |..| . .. ..| ||....   .|. .|| |.|.|     .. .. |  .|   
vpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqeke...ndeevcyqyWpee.....ks.vvlGeyniell

AREgLSMGATKYELELTDsevvidKNSDDPnasnykSHRLIVFHMNTWSGQkptsGnALEQAQNVALFFREVKKFEmdilRKSMENfvpPVMLQSFDGIN
 .|  . | .. .||..       ||....       ...  ... .|  .    |  ... | . | . |  | .    ||. .    ...    |.. 
nee.vnagyierklevkn......knkagd......kqqvkqyqitnWdst....g.kvtepqtillvieemyktq....rkrgnt...sivvhCsdtvG

RASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
|...   | . .. ...    || ...|     . ||. |  |. | . . |
rsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 83-199 1.5e-06 22.6 In-house 63-172 (297) alignment 
Range on Protein: 83-199
Range on HMM: 63-172/297.0
IRDNRRVLCGS----DEEFFPGQYVRMEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDgKCYTYFPTELEQKmeaelmKGTLSIVC
.. .|  |       | ...   .|.    ..|  | | | . .  |...|.... ..| | .|..   .|. ||  |.. .  ..       |..|.| 
ydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddne...rdk.kcaryWsdkgvtt......fGdvsvvl

KAREGlSMGATKYELELTDSE
.. .    |  | |||.| ..
lsvse.reGfikrelevtkgk
subfamily_PTPN1_pd Subfamily PTPN1 85-331 1.1e-10 35.8 In-house 46-268 (290) alignment 
Range on Protein: 85-331
Range on HMM: 46-268/290.0
DNRRVLCGSDEEFFPGQYVRMEGA--EYIIVQAPTKKSSKLIWRVILKDHIRILVCLchdEQMSGSDDGKCYTYFPTELEqKMEAELMKGTLSIVCkARE
  | .|  .| ..   . | .| |  .||. | |  .  .  |... ... . .| |   ...   .  ||..|.|.. | . | .| . .|..    .|
hsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml...nkvvekeqikcaqywPqgee.ekellledtklkvkl.ise

GLSMGATKYELELTDsevvidknsddpnASNYKSHRLIVFHMNTWSGQK-PTSGNALEQaqnvalFFREVKKfeMDilrkSMENFVPPVMLQSFDGINRA
  .   |   |||..              .  ... .. ||  ||.    | | .|. .      |. .|..        |. . | |...    || |.
erksyytvrllelen.............lktqetreilhfhyttwpdfgvpespaaflk......flfkvre..sG....slssdvGpavihcsaGiGrs

STGWVALMLLRDVEKREC---FDVPSLIKAIMKFRNGSISTYYQFCFCMAVCL
 |  ..  .|  .||..     |.   . .. |.| | | |  |. |     |
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
DSPc_SM00195 95-332 7.8e-23 76.5 In-house 54-260 (263) alignment 
Range on Protein: 95-332
Range on HMM: 54-260/263.0
EEFFPGQYVRM--EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPTELEQKMEAElmkgTLSIVCKAREGLSMGATKYE
...    |...  .  .||. |.|...  .  ||.... ...| |.|. .|.    .  ||. |.| | ..|.. .    ..|. ..  |  .   ....
sdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen...gkekcdrywpeesggketfg....kisvklvevekkkdeiilrt

LELTDSEVvidknsddpnasnYKSHRLIVFHMNTWSGQkptsgNALEQAQNVALFFREVKKFEMDIlrksmenfVPPVMLQSFDGINRASTGWVALMLLR
||||  .               ..... ......|  .     .. .....|  ..|.||| .  .         .|.. .. .|..|. |  .. ..|.
leltkegk.............eetrkvtqyqyknWpdh.....gvpdstksvlellravkksksts........sgpivVhCsaGvgRtgtfvtidiils

DVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLN
 .|. . .|. ...|.. | | |...|  |. |.. . |.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 95-332 7.8e-23 76.5 In-house 54-260 (263) alignment 
Range on Protein: 95-332
Range on HMM: 54-260/263.0
EEFFPGQYVRM--EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPTELEQKMEAElmkgTLSIVCKAREGLSMGATKYE
...    |...  .  .||. |.|...  .  ||.... ...| |.|. .|.    .  ||. |.| | ..|.. .    ..|. ..  |  .   ....
sdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen...gkekcdrywpeesggketfg....kisvklvevekkkdeiilrt

LELTDSEVvidknsddpnasnYKSHRLIVFHMNTWSGQkptsgNALEQAQNVALFFREVKKFEMDIlrksmenfVPPVMLQSFDGINRASTGWVALMLLR
||||  .               ..... ......|  .     .. .....|  ..|.||| .  .         .|.. .. .|..|. |  .. ..|.
leltkegk.............eetrkvtqyqyknWpdh.....gvpdstksvlellravkksksts........sgpivVhCsaGvgRtgtfvtidiils

DVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLN
 .|. . .|. ...|.. | | |...|  |. |.. . |.
kleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 95-332 3.6e-10 34.2 In-house 76-281 (290) alignment 
Range on Protein: 95-332
Range on HMM: 76-281/290.0
EEFFPGQYVR--MEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPTElEQKMeAELMKGTLsivckareglsmgatkyE
.|.    |.    |  .||..|.|...  .  |..| .... |.| |..  ..   .  ||. |.|.. ..|.  . .. .|                  
neyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniiee...gkvkCqqYWpds.dtka.ygefsikl.................l

LELTDSEVVIDKNSDDPNASNYKSHRLIVFHMNTWSgqkpTSGnALEQAQNVALFFREVKKFEmdilRKSMENfvpPVMLQSFDGINRASTGWVALMLLR
 | | .| .. | .   . |. ... .. ... .|       |  ... | . | ..|. | .    ||. ..   ....   |.. |...  .| . . 
neetlneyierklevknknsagakqsvtqyqitnwd....stg.kvtnpqtillvieemyktq....rkrgnt...sivvHCSdtvgrsavfcaaattin

DVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLN
 ...    || ...|     . ||. |  |. . . . |.
kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_PTPN12_pd Subfamily PTPN12 96-171 3.9e-07 24.2 In-house 69-143 (290) alignment 
Range on Protein: 96-171
Range on HMM: 69-143/290.0
EFFPGQYVRM--EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPTELEQKMEAELMK
..  .....   .  |||  |.|  |  .  ||.| . ...|.| .|.   .   .  ||  |.| | |...| . ..
dYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevel...gkkkCerYWpeegeeelefgefe
subfamily_PTPN23_pd Subfamily PTPN23 100-333 5.1e-13 43.5 In-house 72-279 (288) alignment 
Range on Protein: 100-333
Range on HMM: 72-279/288.0
GQYVRM---EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPTELEQKMEAELmkgtLSIVCKAREGLSMgATKYELELT
  .|.       ..|. ||| ....   |... ... ...|.| . |..   .. |.  |.|.. .. .. .     ||. .|  . ..    ...|.|.
AsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeel...gkpkvdrYwPedkgetvkfgd....lsvtlksvretet.hvervlkle

DSevvidknsdDPNasNYKSHRLIvfHMNTWSG-QKPTSGNALEQaqnvalFFREVKKFEMDILRKSMEnfvpPVMLQSFDGINRASTGWVALMLLRDVE
           |..  . || ...  ....|.    | | . | |      |. ||..      |||      |....   |..|. .  .    .|..|
tl.........dad..avksvshl..qltsWpelGvPasPetllq......fldevesayeavqrkskt....PlvvhCsaGvgRtgvfalvyaavrele

KREC-FDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLNI
|..   |.. ... . . |  ....  |. |.. . |. 
kgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN13_pd Subfamily PTPN13 101-333 9.7e-09 29.9 In-house 66-268 (273) alignment 
Range on Protein: 101-333
Range on HMM: 66-268/273.0
QYVRM----EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTYFPTELEQKMEAelmKGTLSIVCKAREGLSmGATKYELELT
.....    .  |||..| |  .. | .|...   . .... . .. .   ..  ||  |.| . ..|. .   .. | .     . |. | .  .|...
slikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke...kgkvkchrywPesknkklkv...snrlevellkvqkld.gfvvralavk

DSEvvidknSDdpnasnyKSHRLIVFHMNTWSGQKPTSgnaleQAQNVALFFREVKKFEMDILrksmenfvpPVMLQSFDGINRASTGWVALMLLRDVEK
|||      |        .|...  ... .|   .  |     .|...  | .||.... | .         |..     || |. |  .  ..|  .|.
dse......sg.......esrevahlnfvkwPdhgvPs.....saaellqfvaevrrlqtdag.........PivvhcsaGiGrsGtlitidvvlglier

RECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLNI
 . |||  ... . . |.| . |  |. |.  ..|..
dkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 102-329 9.4e-13 42.8 In-house 55-259 (270) alignment 
Range on Protein: 102-329
Range on HMM: 55-259/270.0
YVR---MEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLchdEQMSGSDDGKCYTYFPTELEQKMEAelMKGTLSIVCKaREGLSMGATKYELELTDs
|||    | ..||  ..|.. . |  ||.|.. . . .| .    ..      ||  |.|.| ..|..   ..|.....    |  . |  . .|.|.. 
yvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt...tgleEkgrkkCerYWpaepkekvkl..edgkikvlal.seekeegyiltrlrlee.

evvidkNSddpnasnyKSHRLIVFHMNTWSG-QKPTSGNALEQAQNVALFFREVKKFEMDilrksMENFVpPVMLQSFDGINRASTGWVALMLLRDVEKR
      ..        ...||. |..|||     |.. .   .....   .|.|...| .     ...   |..    .|..|. |  .  . .| .|..
......kg........eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrseke.....ldkae.PllvHcsaGvgRtGtlialDiavrlLeet

ECFDVPSLIKAIMKFRNGSISTYYQFCFCMAV
.  || ..|... | |   ...  |. |  ..
kkvdvlaiieelRkdRmalvqhpeqyeflyka
subfamily_PTPN6_pd Subfamily PTPN6 103-327 1.7e-09 32.1 In-house 89-290 (306) alignment 
Range on Protein: 103-327
Range on HMM: 89-290/306.0
VR----MEGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsGsdDGKCYTYFPTELEQKMeaelmKGTLSIVCKAREglsmGATKYELEltds
..     . ..||  |   ..  .  ||...... |..| . ..    |    ||. |.|.| |...      |..|. . . .     ...|.|     
ikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevEr.g..kekCarYWPdeeekee.....yGkisvtnvsek....sladYilR....

EVVIDKNsddpnASNYKSHRLIVFHMNTWsgqkPTSGNAlEQAQNVALFFREVKKFEMDILRKsmenFVPPVMLQSFDGINRASTGWVALMLLRDVEKRE
|... |.      .. ...... .| ..|    |  |   .. . |  |...|.. . .. ..       |..    .|| |  |  |  .||. .||. 
elsvskk.....kkkkeerevfqyhfksW....Pdhgvp.kdpgavLdfledvnrkqeeleea....eagpivvhCsaGiGRtGtfiviDillkliekkg

C---FDVPSLIKAIMKFRNGSISTYYQFCFCM
.   .|. .|.| . ..|.| . |  |. |  
ldadidiqklvksvreqrsglvqteqqykfvy
0041856 (Phosphotyrosine protein) phosphatases II 105-329 2.2e-08 29.4 In-house 34-166 (182) alignment 
Range on Protein: 105-329
Range on HMM: 34-166/182.0
MEgaeYIIVQAPTKKSSKLIWRVILKDHIRILVCLChdeqmsgsddgkCYTYFPteleqkmeaelmkgtlsivckareglsmgatK-Yeleltdsevvid
..   .|. |.|....    .| . . .|...|.|.            .. |.|                               . .            
tr...fiatqgpllstvadflrmlkelgittivnlt............eelywp...............................ell............

knsddpnasnykSHRLIVFHMNTWSGQKPTSgnaleqAQNVALFFREVKKfemdilrksmenFVPPVMLQSFDGINRASTGWVA-LMLLRdvekreCFDV
             .  | ..   | .  ...       . .  | .||..               ||      |..|. |  .| ||. .       ...
............erlgiqylylpwpDhgvpd......ldelldfieevle............eggpvlVHCsaGvgRtgtlvaaylmkkl......gvsl

PSLIKAIMKFRNGSISTYYQFCFCMAV
.. .| . . |.|.. |  |. |.. .
eeavklvrsrRpgmvitpnqyfflqla
subfamily_PTPN14_pd Subfamily PTPN14 106-169 2e-06 22.0 In-house 91-151 (300) alignment 
Range on Protein: 106-169
Range on HMM: 91-151/300.0
EGAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmSGsdDGKCYTYFPTELEQKMEAEL
.  .||..|.| ..  .  |...  ......| | ..|. .|    |.. ||| . ..| ..| 
kersyivaqgPleltvqdfWqmvWeqgvqlivmlteeee.dg..keksfkyfPkleskkktvef
subfamily_Ptp69D_pd Subfamily Ptp69D 107-349 1.5e-12 42.3 In-house 90-303 (307) alignment 
Range on Protein: 107-349
Range on HMM: 90-303/307.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMSgsdDGKCYTYFPTELEQKMEaelmkgtlSI-VCKAREGLSMGATKYELELTDSEVVI-DK
  ..|. |.|     .  ||.|   .. ..| |   ....   . ||  |.| | |.. .        .| |  ..|      .. ||...  .    . 
kkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltekn...rkkcakYWpiedevqyg........dilvklvseekhsdyiiReldvskkkeesgev

nsddpnasnYKSHRLIVFHMNTWSgqkptSGNALEQAQNVALFFREVKKFEMDIlrksmenfVPPVMLQSFDGINRASTgWVAL-MLLRDVEKRECFDVP
          .|.... .| ..|        .. |.|. .  . ..|.. .             |...    | .|... .||| .||  ... .. |. 
.........edsrkvvqyhytgWk.....DskvPevargllklieqvrelykln........rsPivvhCsaGvgrsgi.fvaldsllqqlkaedkvdif

SLIKAIMKFRNGSISTYYQFCFCMAVCLNIGK--DTNWCANDCSTALT
  .| . . ||  .  . |. |.    |.  .  ||. . .| . |. 
etvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie
subfamily_PTPRG_pd Subfamily PTPRG 107-339 1e-10 35.5 In-house 90-294 (563) alignment 
Range on Protein: 107-339
Range on HMM: 90-294/563.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTYFPTelEQKMEAelmkGTLSIVCKAREGLSMGATKyELELTDSEVviDKNS
. ..|. | | |.  .  ||.|   .  |.| .   ..   .   || .|.|.  .. ..     |.|..  ...| |.. ... .| . . ..  .|..
skafiatqgplkdtfddFWrmiWeqnvaiivmitnlve...rgrrkcdvYWPk..desety....galqvtlieeevlalytvr.tlviknlkl..kkkk

DdpnasNYKSHRLIVFHMNTWsgqkPTSGNALEQAQNVALFFREvkkfemdilRKSMENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLI
.       . .. . .|. .|    |  |    .. ..    ..          .. .. . |..     |. |. |  |   ||.......  .|  ..
q.....cdteklvrqyhytkW....PdhgvPehslpvLifvkks.........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgfl

KAIMKFRNGSISTYYQFCFCMAVCLNI--GKDTNW
| |   ||  . |  |. |   . |..  .|.|. 
khiraqRnflvqteEqYiflhdalleaiasketel
subfamily_CG7180_pd Subfamily CG7180 107-330 4.2e-10 33.7 In-house 84-286 (296) alignment 
Range on Protein: 107-330
Range on HMM: 84-286/296.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMSgsDdgKCYTYFPTELeqkmEAELmkGTLSIVCKAREGLSmGATKYELELTDSEVVIDKNS
 .|||. .||.|.. .  ||.. ...|  .| |..  ...     ..  |.| .     ...   | . .     . ..   ..... ||   | . .. 
kkeyivteapkketvdefWrlvydeeisavvvLtktfdfa..k..mypsywpnks....keqy..geifveiveekqya.nlkirtfkltkkivalteqe

ddpnASNYKSHRL-IVFHMNTWSG--QKPTSGNALEQaqnvalFFREVKKFEMDIlrkSMENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVP
    .      |.  .|.. .|    . | | ||| .      . | |...   .     ..   ||.  | ||  |.     . . |  ||| |..|| 
....kqvkaetRivklfqlteWeledkvPlstnalie......lrrrvrlwrekv...dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvF

SLIKAIMKFRNGSISTYYQFCFCMAVC
  .| . . |.. . .  .. ..  | 
eavktlrrsRpqLvenveeYkyiYdvl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 107-329 4.2e-10 34.3 In-house 88-278 (305) alignment 
Range on Protein: 107-329
Range on HMM: 88-278/305.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHdeqMSGSDDGKCYTYFPTELEQKMEAelmkGTLSIVCKAREGLSmGATKYELELTDSEVvidkns
  .||. |.| |.  .  ||.|.. ... .| |..   .   .. ||. |.|..  .|.|     | .|.  | ..  | . .. .|...  .       
kkkyivaqgPlkntvadfWrliveekvstivmltk...lveggkdkCrqYWpesktekkef....gefsvelksektas.dyieRklkisiede......

ddpnasNYKSHRLIVFHMNTWsgqkPTSGNAlEQAQNVALFFREVKKfemdilrKSMENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLI
      . .|. .. ... .|    |  |   ..|  .  ....|.|       . ...   |..    .|. |. .  .  . |  ..| |  ||  ..
......dkesrtvlqyqltdW....PdhGvp.qfatsllslikrvqk.......dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevl

KAIMKFRNGSISTYYQFCFCMAV
|.. . | . ..|  |. |.  .
kqlRskrmkmvqtldqYvflhda
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 107-328 7.2e-07 23.6 In-house 72-262 (274) alignment 
Range on Protein: 107-328
Range on HMM: 72-262/274.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLChdeQMSGSDDGKCYTYFPteleqkmeaelmkgtlsivckareglsmG-------------------
   |.  | |  .  .  ||.| .......| |    ... ..  || .|||                                                
skayvatqGPlpntvadfWrmiyqeevqvivmlt...klkeaneqkCavyfP............................daedyeiserygdveikvek

---ATKYELELTDSEVVIDKNSddpnasnykshrliVFHMntWSGQKPTSGnALEQAQNVALFFREVkkfemDILRKSMENFVPPVMLQSFDGINRASTG
     .|...    . .....|              | |.  |  . |    . ..|...  . .||     .  |.. .. . ||..    || |.   
iverndysvrklvlkylerers..............vkhy..wytdWPdhk.sPddantlldlvlev.....eesreeenaklapvvvhCsaGiGrtGcf

WVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMA
  ... .|......  || ...  .   | | . |  |. .   
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihr
0046846 (Phosphotyrosine protein) phosphatases II 107-329 8.9e-07 24.4 In-house 22-168 (176) alignment 
Range on Protein: 107-329
Range on HMM: 22-168/176.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMSGSDdgkCYTYFPTELEQKMeaelmkgtlsivckareglsmgatkyeleltdsevvidkns
|. .|. |.|. ..    .. ... .|...|.|. . ...  .   |..|.| . . ..                                         
gsrpiatqgplprtladflemlkelgitavvnlteevelgrlk...cpnywpeleklgi.........................................

ddpnasnykshrlIVFHMNTWSGQKPTSgNALEQAQNVALFFRevkkfemdilRKSmenfvPPVMLQSFDGINRASTGWVALMLLRdvekRECFDVPSLI
              ..|...  .. |.. ..|... .    ..          ..       ||    . ||.|. |  .|..| .    . ...|   .
.............qylhlpwpDhgvpdl.elllellefireal..........keg.....gpvlVHCsaGigRtgtlvaayllel....ekglsveeal

KAIMKFRN-GSISTYYQFCFCMAV
. . . |  |.. |  |  |.. .
alvreqRplgavqtpeQyrflyef
subfamily_PTPRK_pd Subfamily PTPRK 107-339 1.1e-06 22.7 In-house 85-284 (314) alignment 
Range on Protein: 107-339
Range on HMM: 85-284/314.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLchdEQMSGSDDGKCYTYFPTELE--QKMEAELMKGTLSIVCKAREGLS-Mgatkyeleltdsevvid
 |..|. | | ..  |  ||......   .| |   ...      ||. |.| . |  .... ||.. .|     .|                       
paafivtqgPlqetvkdfWrlvydencasivml...telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrvek.................

knsddpNASNYKSHRLI-VFHMNTWSGQkptsgNALEQAQNVALFFREVKKFEMDilrksmenFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDV
       | ... .|..  |.  .|.       .   .|. .  . |.||| . .           ....    |  |. |  .  ..|  .|...  ||
......largqeeirevrqfqflgWpdh.....dvPvsatgllklvrrvkksqee........eaGrivvhCsaGaGrtGtfiaidivldmieregvvdv

PSLIKAIMKFRNGSISTYYQFCFCMAVCLN--IGKDTNW
   .|.. . .   . |  |. |.  | |.  .  .|  
fnavktlrsrkvnmveteeqykfiydvileaclcgetai
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 107-332 5.1e-06 20.6 In-house 91-277 (315) alignment 
Range on Protein: 107-332
Range on HMM: 91-277/315.0
GAEYIIVQAPTKKSSKLIWRVILKDHIRILVCLChdeQMSGSDDGKCYTYFPTEleqkmeaELMKGTLSIVCKAREGlsmgATKYELELTdsevvidkns
   ||  |.|   | |  ||.. ...|  .| |    ..   .  |.  |.| .       ... | ...  |  |      |.|               
krryiaaqgpnvasvkdfwrlvfeedigkivmlt...nlvegekrkaekywpdk.......kviyGkitvtrkseev....nteytvrtl..........

ddPNASNYKSHRLIVFHMNTWsgqkPTSGnALEQAQNVALFFREVKKFEmdilrksmENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLI
     .. . . .. .|. .|    |..|   . . ..  ..| ||...        .| | ....   .|. |. |      .|  .|  .  ||  .|
..svvfgdnirevvqlhytsw....pdmg.vpkytiplmnlirtvkqhh........tnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfi

KAIMKFRNGSISTYYQFCFCMAVCLN
. . . | . ...  |. |   . |.
tgvrqnrikmvqvaeqyqfiydalle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 108-332 1e-10 36.4 In-house 99-288 (298) alignment 
Range on Protein: 108-332
Range on HMM: 99-288/298.0
AEYIIVQAPTKKSSKLIWRVILKDHIRILVCLchdEQMSGSDDGKCYTYFPTELEQKMEAELMkgtlsivckareglSMGATKYELELTDSEVVIDKNSd
  .|. ||| ... .  ||.. ...|  .| |   ...  .|  |.  |.|.| ... .   .              |. ...   .|.  .. . |.. 
nafiatqaPltetvedFWrmvteedigtiVml...tnleeldktkyhkywPdegketygeitv..............sllskeefadlivrklkvskkk.

dpnaSNyKSHRLIVFHMNTWSGQKPTsgnalEQAQNVALFFREVKKFEMDILRKsmenfvpPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIK
    .. |....  .|. .|. .  .     |.|. |  . |.|.. . .   |       ||..|  .|..|. |  .   .|  |.| .  ||   .|
....ee.kerevrqlhftsWpdkgvp.....enatsvldllrkvrasqqqagnk.......pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvk

AIMKFRNGSISTYYQFCFCMAVCLN
.. | | |.. |  |. |.  . |.
vlRkkrpgavqteeqYvfiyeavle
subfamily_PTPRB_pd Subfamily PTPRB 108-332 1.6e-09 32.3 In-house 94-283 (293) alignment 
Range on Protein: 108-332
Range on HMM: 94-283/293.0
AEYIIVQAPTKKSSKLIWRVILKDHIRILVCLChdeQMSGSDDGKCYTYFPTEleqkmeaelmkgtlsivckaREGLSMGATK-------YELELTDSEV
 |.|  | |  .. . .||...... .|.| |    |.      ||  |.|..                    .|    |  |          . .  |.
refiatqGPlpetvddfWrmvwekkssiivmlt...qlvekgkvkCeeYWPad....................eepvlyGdikvtlvaeeeledwvirel

VIDKnsddpnasNYKSHRLIVFHMNTWSGQkptsGnALEQAQNVALFFREVKkfemDILRKSMENfvPPVMLQSFDGINRASTGWVALMLLRDVEKRECF
 | |        . .....  .|  .|.      |   |.....  |.|.|.    . ..|....   |..     |. |. |     .||...|.... 
kiek........ekeerkvrqyhftsWpdh....g.vPektktlldfvrtvr....eaiektask..rPivvhCsaGvGRtGtfialdrllqaieeedyv

DVPSLIKAIMKFRNGSISTYYQFCFCMAVCLN
|. ... .. . ||  . |  |. |   . |.
difgivaelReeRnllvqtekqYifihqcvld
subfamily_PTPRD_pd Subfamily PTPRD 108-332 1.6e-09 32.0 In-house 91-279 (564) alignment 
Range on Protein: 108-332
Range on HMM: 91-279/564.0
AEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEqmsGSDDGKCYTYFPTElEqKMEAelmkGTLSIVCKAREGLSMGaTKYELELTDSEvvidknsd
 .||  |.|.... .  || .   .... | | . |    ..  ||  |.|.. . . .     | | .  .. | |.   .  ...|....        
kayIAtqgPlaetiedFWRmvweqnsstiVmltkle...EkgkvkchkYWPek.g.tety....geltVtleeeeelady.eirtfklkkkk........

dpnasNYKSHRLIVFHMNTWsgqkPTSGnALEQAQNVALFFREVKKFEMdilrksmeNFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIK
     . .|.    ||   |    | .| . |.|...  . |.|.. .         .   |.. .   |. |  |  |  ..|. ... .  |. . .|
.....ssesreVrqFhFtsW....Pdhg.vpesatslLdlirkvralne........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvk

AIMKFRNGSISTYYQFCFCMAVCLN
|. | ||  . |  |. |.  . |.
alrkqRnamVqteeQYiFiheaile
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 108-347 4.6e-08 27.2 In-house 88-300 (305) alignment 
Range on Protein: 108-347
Range on HMM: 88-300/305.0
AEYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTYFPTELEQKMEAELMKGTLSIVCKAREGLSMGAtKYELELTDSEVVIDKNSD
  .|  ||| .|.   .| . |.|..  .  ||   .       ||. ||... ....| |     .|. ... . |.. . . . ..|....||.    
krfictqaplektcadfwymclqdkveaifmlcnlle...kgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrk.dakakvtetvlviegpge

dpnasnyKSHRLIVFHMNTWsgqkPTSGnaLEQAQnVALffrevkkfeMDILRKSMENfVPPVMLQSFDGINRASTG-WVALMLLRDVEKRECFDVPSLI
       |...   .| . |    |  |  .  |. .|.         ...| |.      |...    || |. .   .  .| . .. .   |   ..
.......karkvthyhwidw....pdrg..vpaad.lai.........lellekarps.kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkil

KAIMKFRNGSISTYYQFCFCMAVCLNIGKDTNWCANDCSTA
. | . || || |  |. |   | ||  .. .   .. ..|
qkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea
subfamily_PTPN9_pd Subfamily PTPN9 109-332 7.5e-07 23.4 In-house 86-288 (297) alignment 
Range on Protein: 109-332
Range on HMM: 86-288/297.0
EYIIVQAPTKKSSKLIWRVILKDHIRILVCLCHDEQMsgsDDGKCYTYFPTELEQKMEAelmkGTLSI--VCKAREglsmgaTKYelelTDSEVVIDkns
 .|  | | || ..  ||..  ......|   . ...      ||  |.|.| |. .|     | ||.  |    |       .|    . . ..|.   
afiatqGplkktvsdfWrmvWeqevlvivmttrvver...grlkcgqyWpleeessaef....gdlsvsnveveee......edy....kvrvleik...

ddpNASNYKSHRLIVFHMNTWSGQ-KPTSGNALEQAQNVALFFREVKKFEMDIlRKSMENFVPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSL
   |. . .| ... | . .|     | |...| .  ...   . .   |.   ..  .   ||...    || |. |     . |  .|. .  ||   
...nvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd.ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvet

IKAIMKFRNGSISTYYQFCFCMAVCLN
.| . . |  || |  |. ||    |.
vkllrtqrafsiqtpeqyefcylavle
0036282 (Phosphotyrosine protein) phosphatases II 109-327 3.4e-06 22.4 In-house 18-163 (174) alignment 
Range on Protein: 109-327
Range on HMM: 18-163/174.0
EYIIVQAPTKkssklIWRVILKDHIRILVCLCHDEQmsgSDDGKCYTYFPTeleqkmeaelmkgtlsivckareglsmgatkyeleltdsevvidknsdd
..|. |.|..      |. . . .|...|.|.. ..    . .||. |.|.                                                 
rliagqgpla.....fwemlkelgittvvmlleeke...lglykcinywpe.................................................

pnASNYKSHRLIVFHMNTWSGQKPTSGNALEQAQNVALFFRevkkfemdilrksMENFVPPVMLQSFDGINRASTGWVALMLLRDVEkRECFDVPSLIKA
   ... ..  | ..   | .  . . . |... . .  ..              |.   ||      |..|. |  .|...||  .     |. .|...
..lredlerlgiqylylpwpDhgvpdlsillefvkfveeal.............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvre

IMKFRNGSISTYYQFCFCM
. . | |.. |  |. |. 
lRlqrpgmvqtpsQyrfly
0051082 (Phosphotyrosine protein) phosphatases II 110-328 2e-06 23.0 In-house 15-147 (151) alignment 
Range on Protein: 110-328
Range on HMM: 15-147/151.0
YIIVQAPTKksskLIWRVILKDHIRILVCLCHDEQMSgsddgKCYTYFPTELeqkmeaelmkgtlsivckareglsmgatkyeleltdsevvidknsddp
... ..|.       .. . . .|.  |.|. .| .      .|. |.| .                                                 
lyrsggpla....dflellkelgiktivnlrseeerg.....ycpeylpelg................................................

nasnykshrLIVFHMNTWSGQKPTsgnaleqaqnvalfFREVKKFEMDILRKSMENFVPPVMLQSFDGINRASTGWVALMLLRDvekrecFDVPSLIKAI
         . |.|.  .. . |.              . .  .. ...|.. ...   ||      |..|  |  .....|..      ... . .. .
.........ievlhipildwpdpg..............lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeey

MKFRNGSISTYYQFCFCMA
...| |.. .  || |.. 
rlkrpgvvqpnqqflfqlf
PTPc_DSPc_SM00012 221-331 5.4e-19 63.7 In-house 4-104 (105) alignment 
Range on Protein: 221-331
Range on HMM: 4-104/105.0
VFHMNTWSGQkptsgN----AleqaQNVALFFREVKKFEMDILRksmenfVPPVMLQSFDGINRASTGWVALMLLRDVEKR-ECFDVPSLIKAIMKFRNG
..|...|. .     .    .    ...  ..|.|||.. .. .       .||......|..|. | ... .||...||. ...|.  ..|...| |.|
hyhytgwpdh.....gvPees....dsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpg

SISTYYQFCFCMAVCL
...|..|..|.....|
mvqteeqylflyrall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 267-334 6.3e-06 20.4 In-house 212-279 (288) alignment 
Range on Protein: 267-334
Range on HMM: 212-279/288.0
VPPVMLQSFDGINRASTGWVALMLLRDVEKRECFDVPSLIKAIMKFRNGSISTYYQFCFCMAVCLNIG
. |.. .  .|. |. |  .. .|.  ||. .  || . .. . | |.  . | .|. |.  | |.. 
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli