Synonym: CELE_C55B7.3, C55B7.3
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
0050432 | (Phosphotyrosine protein) phosphatases II | 32-323 | 8.2e-81 | 267.0 | In-house | 22-303 (308) | alignment | ||
Range on Protein: 32-323
Range on HMM: 22-303/308.0
VERKQQKKQILKFVQRtlEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLegPWPHEYIHANYVATP--TNPKRFICTQAPL
. |. ...||.... . ...|..|| .... . ....... . ||||||. ..|..|||| . .. ||.|.|| .. .|..||.||.||
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPl
EKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG-DVMDFEeggqKISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWND
..|..||| |... .|..| ||..| |.| ||..|.|.. | ... .. |..|.. | . ....| ... .. ....|. ||.|. .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfhytn
WPDRGVPAADMAVLELLENARPS--KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
||| ||| ..|..|| .| | .||||||||||.|||| ...|.....|| ... .| .... |.||||....|| ||||.....| |...|.
WpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd.vfeavkklReqRpgmvqtpeqylflyralleylklkl
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 33-338 | 1.9e-199 | 655.7 | In-house | 1-305 (305) | alignment | ||
Range on Protein: 33-338
Range on HMM: 1-305/305.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
|.|||||||||||.|||||.|.|||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt
CADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG
||||||||.|||||.||||||||||||.||.|||.||..||..|||.|||||||.|||||..||.||||.||.|..||||||||.||.|||||.||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg
VPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETgVQE
|||||.|.|||||.||||||||||||||||||||||||||||.|||||||||.|..|||.||||||||||||||||||||||||||||||||..|. |.|
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee.vke
AYDAFL
||.|||
aykafl
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 33-319 | 2.4e-52 | 173.0 | In-house | 6-290 (298) | alignment | ||
Range on Protein: 33-319
Range on HMM: 6-290/298.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFND---FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQ
| .. |... |... . .| |. .|| ... .. |.... .. . |||| |. || || || .|| | .. . .. . || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq
APLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDfeeggqKISVkcessvtYSFRSDAKANVTATEIVIEG-PGEKTRKTTHYHW
|||..| .||| | ..... | || || |.. |. .|.|... . . .|.| ... .|... ... .. ||.|. . |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg......eitv.......sllskeefadlivrklkvskkkeekerevrqlhf
NDWPDRGVPAADMAVLELLENARPS---KG--PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
|||.|||. .||.||.. | | | |..|.||||.||.|. . .. ..... . | .| ... .|..| ...|| .|| |.....|...
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDv.fqvvkvlRkkrpgavqteeqYvfiyeavleal
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 35-324 | 1.7e-66 | 218.9 | In-house | 8-288 (290) | alignment | ||
Range on Protein: 35-324
Range on HMM: 8-288/290.0
KQQKKQILKFVQRTLEKMPQGLRAEFVG-MRRF--NDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATpTNPkRFICTQAPLEK
| . . || . .| ...| |.. .. . .. . | | . | ||||||| | | || |. . .|.||||| ... || || .|..
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG.lka.mfiltqGalkd
TCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEggqkISVKCESSVTysfrSDAKANVTaTEIVIEGPGEKTRKTTHYHWNDWPDR
| |.| | |.|| .| |||.|.|.| || .|.| |.|.|. | | |.| | . . ||. | | . | | |.. |||.
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe....itvlcseedd....kdaniikk.tlsvrdkdsGkehklkhlkikswpdk
GVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKL
|. ...|.| .| | ||.||||||||||||. | .| .. || |. .| . . .|. | ||.| | ||| . ...|.. .. |
svalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlld.lvralrnsrlnsvqvdiqylalveilldlGkdfky
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 36-323 | 1.1e-60 | 200.1 | In-house | 7-289 (293) | alignment | ||
Range on Protein: 36-323
Range on HMM: 7-289/293.0
QQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
..... ..|... .. .. |. .. .. ...|| ..|... ||||... |..|||| .. .|| |||. . |. || || || .|
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet
CADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkgdvmdfeeggQKISVKCESSVTYSfRSDAKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRG
||| |....|.. | || .|.||| || ||.|.. .. . . .|| .. . . . |. || ....||...||. ||| |
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...........eepvlyGdikvtlv.aeeeledwvirelkiek.ekeerkvrqyhftsWpdhg
VPAADMAVLELLENAR------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
|| . ..|..... | ||.|||||||||.|||| . |. ..... ...| |....||.||. .|| .||.|.||..|...|||.
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi.fgivaelReeRnllvqtekqYifihqcvldllrkke
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 37-319 | 5.6e-78 | 257.6 | In-house | 6-286 (288) | alignment | ||
Range on Protein: 37-319
Range on HMM: 6-286/288.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTC
. ...||.|...| . . ||..|| ..... ...|.. . ||||.|. ..|..|||| . .. ||.|.|. .. ....||.||.||..|.
sveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv
ADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-----PGEKTRKTTHYHWNDW
.||| |... .|..| ||..| |.| .||. |.|. |... ... |.|.. | .. ....| ... .. .....|. ||.|. .|
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnw
PDRGVPAADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
|| ||| ..|..|. .| . .||.|||||||.|||| ...|.....||.... .| .... ..||||....|| ||.||....| |.
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.vleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 37-322 | 3.1e-77 | 254.2 | In-house | 7-292 (305) | alignment | ||
Range on Protein: 37-322
Range on HMM: 7-292/305.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMK-AFKEAQE----AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNP-KRFICTQAPLE
. . .||.|.|. . || || |. .. . . ||. | ||||.|| | |.. |||. | | .||||||| | | |||||.| ||.
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld
KTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGgqkISVKcESSVTYSFRSDAKANVTATEIVIEgpGEKTRKTTHYHWNDWPD
.| .||.| |.||| | |||. .| | || .|.| .|. ... | | |. . | . . ||. ..| .. |... | .|..|||
qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg...ivve.nvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpd
RGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
|||| . .. |||| | || ||||||||||||||..| .|||.... . ... .|.|| |||.| ||||.|.|.|||| .|
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 37-321 | 2.9e-75 | 249.2 | In-house | 10-306 (307) | alignment | ||
Range on Protein: 37-321
Range on HMM: 10-306/307.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFND--FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYV--------ATPTNPKRF
. ...|..|...| . ..||..|| ...... ...... . ||||||. ..|..|||| . . . ||.|.|| .. ....|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf
ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkGDVMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG--PGEKTRKT
|.||.||..|..||| |... .|..| ||..| |.| .||..|.|.. |... ... . |.. | . ....| . . .. . ...|.
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrtv
THYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKIREQRNNSIQTDAQYLFVH
||.|. .||| ||| .|...| .| ..||..||||||.||||..... ....|| ..... | .... ..|||| ...|. || |..
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
QVILNYFRK
...| ...|
eallelllk
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 38-326 | 2.4e-53 | 176.1 | In-house | 10-304 (306) | alignment | ||
Range on Protein: 38-326
Range on HMM: 10-304/306.0
KKQILKFVQRTLEKMPQGLRAEFVGMRRF---NDFEKMKAFKeAQEAGKNRYKDVGCLDNNRVKL-EGPWPH-EYIHANYVA--TPTNPKRFICTQAPLE
.... .. . . .. .|. || ... . ...... | .. . ||||| . |..||.| | | .|| |||. .... |..| || ||
eqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle
KTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMdfeEGGQKISVKCE-SSVTYSFRSDAKANVtateivieGPGEKTRKTTHYHWNDWP
.| .||| | .|.. . | |. . .|.| || |.|... . . | ... | | .| .|. ... ....|. .||...||
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskk........kkkkeerevfqyhfksWP
DRGVPAADMAVLELLENAR--------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
| |||. |||..||. . ..|||||||||||||||...... ..... . | .|. ..||||. .||..|| ||...| .|
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
RKKKLME
..|| .|
etkkkle
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 39-325 | 4.3e-80 | 264.6 | In-house | 3-282 (317) | alignment | ||
Range on Protein: 39-325
Range on HMM: 3-282/317.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCAD
...|..... | .. ..|. || ..... .. .. . .||||.|. ..|..|||| . . . ||.|.|| .| ...||.||.||..|..|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved
FWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDFeeggQKISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|..| ||..| |.| .||..|.|. |... . ...|.. | .. .|..| ... .|. ....|. ||.|. .||| |||
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvp
AADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLM
.|..|| .| . .||..||||||.||||..........|| .. . | |... ..||||....|| .|| |.....|.|...| .
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleylkrkltl
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 39-319 | 1.1e-71 | 236.9 | In-house | 5-277 (278) | alignment | ||
Range on Protein: 39-319
Range on HMM: 5-277/278.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDfEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCAD
|..||.... | .....|..|| ...|. . .. .. . ||||||. ..|..||||. .. ||.|.|| .. |..||.||.||..|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved
FWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPskkGDVMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|. | ||..| |.| ||..|.| |... ... ..|.. . . ....| . . .. ..|. ||||. .||| |||
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvp
AADMAVLELLENARP----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
.|..|. .| |.||..||||||.|||| ...|.....|| .. .| |... ..|||| ...||. || |.....| |.
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 40-324 | 4.3e-57 | 188.4 | In-house | 2-295 (297) | alignment | ||
Range on Protein: 40-324
Range on HMM: 2-295/297.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.| ..|. || .||. |.. .|. . ...|.| . ||||.|| |.|. ||.|. . .||.||.| ..| || || ||.||. ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf
WYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEeggqKISVKCES---SVTYSFRSdakanVTATeiviEGPGEKTRKTTHYHWNDWPDRGV
| | ....| | | ..|.| .|| .|.|........| ..||. . . | .|. .... . |..|| ||. ||| ||
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvsnveveeeedykvrv.....leik....nvkteesrkvthfqflsWPdyGv
PAADMAVLELLENAR-----------------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVIL
| . ...|..||..| ||. |||||||||||||| . |.. ...| . .| . . ..|.|| ||||. || | .. .|
PssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdv.vetvkllrtqrafsiqtpeqyefcylavl
NYFRKKKL
.| ..|
eyalelka
|
|||||||||
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 40-344 | 5.4e-47 | 155.0 | In-house | 5-299 (312) | alignment | ||
Range on Protein: 40-344
Range on HMM: 5-299/312.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGPWpHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
| |. . || | |. . . || .. ||| .. | | | | | |||||.| |.|.||.|||.|||.||. || .
mikkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwql
CYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdVMDFEEggQKISVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTrKTTHYHWNDWPDRGVPAADMA
. | .|| ..| |. || .| | .|.|. ... . . . .| | .|. |... | || | ||| |.| . .
alslgstsiillcgfvedgsekcakyisdivg.fvdled..hrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdt
VLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQiIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETgvQEAYDAFLE
| || . | |.. |||||.||||.....| .. | . .. ...| .| .| |... .||... ...|... | |.. .. . | |
alrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn..eqewtkfke
QYKKV
| |.
tyaki
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 40-321 | 1.6e-42 | 140.5 | In-house | 6-280 (287) | alignment | ||
Range on Protein: 40-321
Range on HMM: 6-280/287.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEK-MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWY
.. .||.. .| .| . |. . . .. |. . | |||.... ||.|| |.| ..|| | .. . . |.|| ...|. .| .||
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk
MCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdV-MdfeeGGQKISVKCESsvTYsfrsdAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG-VPAA
. . .|. | |||.. |. ..|..|.|..| | . | .|.. | .. |. . |. .. ..... . |. .|...| |.
liddrnvtaivmlcqekendeevcyqyWpeeks.vvl....Geyniellnee..vn.....agyierklevknknkagdkqqvkqyqitnWdstgkvtep
DMAVLELLE----NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.| . | . ......||||||...||.. . . ... .|| ..| . | |. .|.|| .|| |. ...|.|
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleylds
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 41-321 | 6.5e-62 | 204.9 | In-house | 10-283 (564) | alignment | ||
Range on Protein: 41-321
Range on HMM: 10-283/564.0
ILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAqEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFW
. ..|.. . . . |. ... . |.. .| |.| ||||... |..||.| || .|| |... . ...| .| ||.||..|..|||
lkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW
YMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkGdVMDFeeggQKISVKCESSVTYSFRSDAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPAAD
|... ... | || .| ||| || .|.|.| | . ... |. |...... . . ... .. ...|. ...|. .|||.|||
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety....geltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgvpesa
MAVLELLENAR----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
..|.|... | | .||||||||||.|||| . ........ . . .| ... ..|.||| .|| || |.|..||.. .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDi.yqyvkalrkqRnamVqteeQYiFiheailealac
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 41-315 | 1.3e-34 | 114.2 | In-house | 17-288 (297) | alignment | ||
Range on Protein: 41-315
Range on HMM: 17-288/297.0
ILKFVQRTLEKmPQGLRAEFVGMRRFNDFEKMK-AFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVAT--PTNPkRFICTQAPLEKTCA
.|.... |.. .. |..|. .. ... .. | . |. . . |||.|.| |..||||. ..|| | . | .| .| ||.|| .| |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva
DFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEG-GQKISVKCEssvTYSFRSDAKANVTATEiviegpgekTRKTTHYHWNDWPDRGV
||| | ... | | .|..| |.| ..| .|.| . .| .. | . |. | || |. ..| || | .|. ||..||
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcd...dylvrsfylknlqtse.........trtvtqfhflswpeegv
PAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVI
||. ..||. | |||||||.| |||| .... ....|| | | | ..|.||.. ..| .|. |. ...
PasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 42-321 | 1.9e-44 | 146.7 | In-house | 8-285 (290) | alignment | ||
Range on Protein: 42-321
Range on HMM: 8-285/290.0
LKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE-----GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.||. | .| |..| . .. .... .. .||.... |.||. | ..|||.| |. . |..| ||.|...| .||
gefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF
WYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkgDVMDFEEggQKISVKCESSVTysFRSDAKANVTATEiviegPGEKTRKTTHYHWNDWPDRG-VPA
| . .|.|| | ||.| |.| || |.|.. |. ...| .| . |.... | .|. .. ...... |.|. |.. | |..
WkliwqekvtiivmltniieegkvkCqqYWpds..dtkayge..fsikllneetln..eyierklevknkn.....sagakqsvtqyqitnwdstgkvtn
ADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.| . | .. ...||||||...||.. . .. ... . || ..| . | |. .|.|| || ...|..|.|. .
pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidv.fqvlksqRiqkpgsvqtvqqyqgifqivltylds
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 43-328 | 3.3e-81 | 267.6 | In-house | 5-288 (307) | alignment | ||
Range on Protein: 43-328
Range on HMM: 5-288/307.0
KFVQRTLEKMPQGLRAEFVGMRRFNDF-EKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGP-WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
.|||||.| | |. || . . . ..||. .. ||||.|| | |..|. .. . .||||||. . ..||.|||.| |||.| .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama
YQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCESSVTYSFrSDAKANVTATEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAV
|.||| . |||...| . || .|.| ..|. . | | .. |||. . . . . |||. ... ..|.| .|. |..||||||| ...
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklap.dedlinvttlkvdw...aqksrtiqhlqwenwpdrgvpqinlta
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK--KKLMEET
..||| | . |.|||||||.||.|..| . ...|...||. | .|.. ..|.||. .|||.||||..|.|.|.|| . |. ||
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 43-331 | 1.6e-55 | 183.2 | In-house | 10-285 (288) | alignment | ||
Range on Protein: 43-331
Range on HMM: 10-285/288.0
KFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
. |... . .|. |. . .. .. .| ..|. | ||||... .| .||||.. .|| |.|.. . |..|.||.|| .| ||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel
CYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVmDFeeGgqkisvkcesSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMA
|..|.. | || .|.|.| .|| ||.|... . . | ||| ... . . . .. .. . .. ...|.|.. ||| |||.. .
vyenktstivmltelveggktkCeeYWPdadkpk.ny..G..........svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskap
VLELL---ENARPSK-GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILnyfrkkKLMEETGVQ
.|||| ..| ... |||.||||||.|||| . |. ..|.. . . || . .. |.|.||.. .|| || |...|.| .|.|| ||.
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevll......slieedgva
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 44-322 | 9.7e-52 | 170.8 | In-house | 5-279 (281) | alignment | ||
Range on Protein: 44-322
Range on HMM: 5-279/281.0
FVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
.... .. .|. |. ... . . .| |. . ||||... |. |||. | .|| ||.|.. ...|..| ||.|. .....|| |
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv
YQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdvmdfeeggqkiSVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAV
.. ||. | |. . .|.| || |.| .. ..| . | .. .||. .. .| . .||. .. .. ||| |||| ...
weqkvsaivmvtreieagklkChrYWPddns............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkel
LELLENA----RP-SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
|| .. .. .| |.|.|||||.||||. . |. ..... | . | . .. ..|..|| .|| .|| ||....|... |.
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 45-322 | 6.3e-52 | 171.6 | In-house | 14-286 (319) | alignment | ||
Range on Protein: 45-322
Range on HMM: 14-286/319.0
VQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCY
... .. ..|. || .. ... ... .. . ||||... |. ||.| .| .|| |... . . ..|| ||||||.| ||| | .
lkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW
QDKVEYIFMLCNLLEKGARKCFEYFPSKKgdvmdFEEGGQkISVKCESSvtysfrsDAKANVTATEIVIEGPGEK--TRKTTHYHWNDWPDRGVPAADMA
.... . ||..| ||. |. .|.|... |||.|. . |. |. . .... .. .. .. ||. .|.....||| .|| ..
eeessivvmltklveklkvklkkywpeen.....feeyGr.livtleee.......eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats
VLELLENAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
.|.||.. | ...||||||||||.||||. ..|. ..... ...| .. ..| ||| .|. .|| |.....|..
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyealleaveag
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 51-321 | 2.6e-51 | 169.5 | In-house | 17-282 (318) | alignment | ||
Range on Protein: 51-321
Range on HMM: 17-282/318.0
KMPQGLRAEFVGM-RRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVE
. | .|. . | . . ..|. | . |||| .. |. ||||. | .|| |||. .. | .| .|||| .|. ||| | .. .
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa
YIFMLCNLLEKGARKCFEYFPSKKGDVMDfeeggqKISVKCESSVTYSFRSDAKANVTATEIviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
| || .. |.| .|. |.|||. .. |. |. ...|..| . .|| || |..|. ||. .|||.|||. . .|.|. .
vivmltqeeergkakvhryWPskgsrsyg......klvvelkeevelsdyvlrefkvtrtee......eesrqvrqyhytsWpdegvpesgaslldlvrq
A-----RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
. ....||||||||||.|||| .... ..... | ...| .. ..||||| .||. || |...|.|..
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvllealas
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 53-326 | 2.1e-78 | 258.9 | In-house | 12-284 (297) | alignment | ||
Range on Protein: 53-326
Range on HMM: 12-284/297.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|. || . .. ...... . ||||||. ..|..|||| .. .. ||.|.|| .. ...||.||.||..|..||| |... .|. | ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt
NLLEKGARKCFEYFPSKKGDVMDFeeggQKISVKCESSVTYsfrsdAKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP--
.| |.| ||..|.|...|... . ...|.. | .. ....| ... .. ....|. ||.|. .||| ||| .|...| .|
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl
----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA--GQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLME
|.||..||||||.||.|..........|| . | ... |.||||....|| ||.|.....|....||...|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 53-319 | 6.1e-75 | 247.5 | In-house | 11-272 (273) | alignment | ||
Range on Protein: 53-319
Range on HMM: 11-272/273.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|..|| .... . ...... . ||||||. ..|..|||| |. .. ||.|.|| .. ...||.||.||..|..||| |... .|..| ||.
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt
NLLEKGARKCFEYFPSKKGD-VMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-
.| |.| .||. |.|.. |. .. ... ..|.. | | |...| ... .. ...|. ||.|. .||| |||. .||..| .|
elvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka
-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
|.||.|||||||.||||....|....||| ... .| .... ..|.|| ...|| ||.|.....|.|.
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 53-320 | 1.3e-53 | 177.2 | In-house | 21-284 (305) | alignment | ||
Range on Protein: 53-320
Range on HMM: 21-284/305.0
PQGLRAEFVGMRRFNDfeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.|| |.. . . .. ... |. ... |||.|.. ||..|..| ..|| |.|| . . |..| .|.||..| ||||.. .. ||. |
dkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv
MLCNLLEKGARKCFEYFPSKKGDVMDFeeGGqkISVKCESSVTYSFRSDAKANVTATEIviegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN---
||..| | | || |.| .|.....| | .||. .|. |.| | ... . ...| ..|. |||| ||| ..|.|...
mltklveggkdkCrqYWpesktekkef..ge..fsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk
-ARPSKG-PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
. .|| |..||||||.|||| .... ...| . ...| ..| ..|..| . .|| .|| |.|... ..
dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdv.fevlkqlRskrmkmvqtldqYvflhdaldelit
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 54-322 | 1.3e-70 | 233.5 | In-house | 32-292 (297) | alignment | ||
Range on Protein: 54-322
Range on HMM: 32-292/297.0
QGLRAEFVGMRRFNDfEkMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYI
..|..|| . .... . .. .. . ||||||. ..|..|||| .. . ||.|.|| .. ...||.||.||..|..||| |... .|..|
tllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi
FMLCNLLEKGArKCFEYFPSKKGdvmdfE--EggqkISVKCESSVTysfrsdaKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
||..| |.| ||..|.|.. | . . ..|.. . . ....| ... .. ....|. ||... .||| ||| .||.||
vmLtklvelgr.kcaqywpeegg.....tygd....ftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflel
ARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
.| ..||..||||||.||||..... ....|| .. .| .... ..||||....||. || |.....| ....|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 54-343 | 4.7e-52 | 172.0 | In-house | 19-314 (563) | alignment | ||
Range on Protein: 54-343
Range on HMM: 19-314/563.0
QGLRAEFV--GMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEY
.|. .|| .. .. .... .. .. |||| .. |. ||||.. ..|| |||. | || || ||..|. ||| | .. .|.
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai
IFMLCNLLEKGARKCFEYFPSkkGDVMDFEeggqKISVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE--
| |. || |.|.|||. |.|. ...... ...|. ... . . . . . ... . .. .. ..||. .||| ||| . || .
ivmitnlvergrrkcdvYWPk..desetyg....alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks
-NARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK-LMEETGVQE--AYDAFLEQ
|... ||||||||||.|||| ..|. .. |. . .... ..| .|| |||. .|| ||.|.|...|. . |. . .. |.| .|||
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavn.vfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyleq
YKK
|
qyk
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 54-321 | 6e-51 | 168.1 | In-house | 5-270 (274) | alignment | ||
Range on Protein: 54-321
Range on HMM: 5-270/274.0
QGLRAEFVGMRRFNDFEKMKAFKeaqEAGKNRYKDVGCLDNNRVKLEGPWPH----EYIHANYVATPT-NPKRFICTQAPLEKTCADFWYMCYQDKVEYI
. |..||. . | |... |. .. |||||.. .| || || .. .|| |||. . . | .. || || .| |||| | ||..|. |
kdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi
FMLCNLLEKGARKCFEYFPSKKGdvMDFEEGGQKISVKCESSVtysfrsdAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENAR
|| .| |. .|| .||| ... .. .| .....| |. | . . . ...|.. . .|. .|| . ||||. .| ..|.|... .
vmltklkeaneqkCavyfPdaed..yeiserygdveikvekiv.......erndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleve
P-------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.|.|||||||||||| . . . || . ...| || ...| .| .||. || ..|... | ..
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclylkr
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 54-322 | 1.8e-50 | 166.8 | In-house | 22-289 (307) | alignment | ||
Range on Protein: 54-322
Range on HMM: 22-289/307.0
QGLRAEFVGMRRFnDFEKMKAFKEAQ-EAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.|| |. . . ..| . | . | ||||.|. |..||||. | .|| |... . . |.||. |.|.| | ||| | . .|. |
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv
MLCNLLEKGARKCFEYFPSKkgDVMDFEeggqKISVKCESSVTYSFRSDAKANVTATEIViEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--
|| || || .|| |.| | . .. .| ||. |. . | . .|. .. | |..|| . ||.. |.| || . ..|.|.|..
mlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkee.sgevedsrkvvqyhytgWkDskvPevargllklieqvre
--RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
. ...||||||||| ||.| .| |. ...|| | . .| | . ..|.||| .| .|| |... .|.| .
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife.tvkdLrsqRnllvqsleqYvflyralldyssyg
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 54-329 | 4.9e-29 | 95.7 | In-house | 26-294 (302) | alignment | ||
Range on Protein: 54-329
Range on HMM: 26-294/302.0
QGLRAEFVGMRRF-NDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNPKRFICTQAPLEKTC---ADFWYMCYQDKVEYIF
. ...|| . . | || ||||. . ||. .|| .||.|.||||. | .|..| | | . | .| | .. ..|| | .|.|. ..
aevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv
MLCNLLEKGArKCFEYFPSKKGDVMDFEeggqKISVKCESsVTYSfrSDAKaNVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMA----VLELLE
.| | |.|| | || ... |. | | .. ...| . . |.. || . .. |. . |.. || . . .. .
ilvgeeelkk.tlselfpkksgdykeyg....kmfvNnrk.Veka..eeek.tryviEvlPegcsnsvl.anvyvltnWkqkkvpvkyaeliktaakvfa
NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILnYFRKKKLMEETG
. ... ..|. |.|| |... | ...| .|. | |. .||.|| ..... || ... ..| .. |||. ....
kkikadentvivSknGaGRagafltlavaveklqkgkepnike.ivksiRsqRpravdslkQyvslyiall.lyikkkvtkpee
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 55-324 | 7.8e-77 | 253.7 | In-house | 1-279 (284) | alignment | ||
Range on Protein: 55-324
Range on HMM: 1-279/284.0
GLRAEFVGMRRFNDFE--KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATP-----TNPKRFICTQAPLEKTCADFWYMCYQD
||..|| ..... . ...... . ||||||. ..|..|||| . . ..||.|.|| .. ..|.||.||.||..|..||| |...
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq
KVEYIFMLCNLLEKGARKCFEYFPSKkGDVMDFeeggQKISVKCESSVTysfrsDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLEL
.|..| ||..| |.| ||. |.|.. |.|. . ...|.. | . . |. |.. .|.....|. ||.|. .|||.|||. .||.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef
LENARPS------KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQI--IDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKL
|. .| . .||||||||||.|||| ...|.....|| .... | .... ..||||....|| .||.||....|.|...|.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 57-319 | 1e-48 | 161.0 | In-house | 14-269 (273) | alignment | ||
Range on Protein: 57-319
Range on HMM: 14-269/273.0
RAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPheYIHANYVATPTNPKRF--ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNL
|| .| . .. . |.... ||||..| |. ||||.. . || |... | . ... | .| || .|..||| | .. |.| | |. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle
LEKGARKCFEYFPSKKGDVMDFEeggQKISVKCESSVTYSfrsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR---PSK
||| || |.|..|.. . . ... |. . . .. . | . |.. ...|. .| .. .||| |||.. . .|... . | ..
kekgkvkchrywPesknkklkvs...nrlevellkvqkld......gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda
GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
|||||||||||||.|... .. ... . . . | ..|. |.||||. .||. ||.||...||. .
gPivvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreqrqgvvqtkdqyifvykailevl
|
|||||||||
DSPc_SM00195 | 59-319 | 2.7e-77 | 255.0 | In-house | 5-262 (263) | alignment | |||
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLL
|| ... . .... .. .. |||||.. . |..||||. . ...||.|||. .....|..|.||.||..|..||| |... ||..| ||..
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee
EKGARKCFEYFPSKKGDVMDFEeggqKISVKCESSVTYSfrsdakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|. |||||. . ... .... ... .. | |.|||.|.|....|||.||| . |||||. .. |
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts
KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ... .| ..|. ..|.|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
PTPc_SM00194 | 59-319 | 2.7e-77 | 255.0 | In-house | 5-262 (263) | alignment | |||
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLL
|| ... . .... .. .. |||||.. . |..||||. . ...||.|||. .....|..|.||.||..|..||| |... ||..| ||..
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee
EKGARKCFEYFPSKKGDVMDFEeggqKISVKCESSVTYSfrsdakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|. |||||. . ... .... ... .. | |.|||.|.|....|||.||| . |||||. .. |
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts
KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ... .| ..|. ..|.|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 59-321 | 2.4e-54 | 179.2 | In-house | 20-277 (280) | alignment | ||
Range on Protein: 59-321
Range on HMM: 20-277/280.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPhEYIHANYVATPTNP----KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNL
.| . | . ...| . .... ||||.|. |. ||||. .|| |||| . .|.| || ||.||..|||.| ...|.. | || .|
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl
LEKGARKCFEYFPSkKGDVMDFeeGgqKISVKCESSvtysfrsDAKANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK--
.|.| || .|.|. ..| ... | ..|||||.. |.. .. |.|.. .. || .. . .||| ||| .||..|. | .
verGrvkChqyWPe.tedeley..g..efsvkceke.......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg
--GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
|.|||||||||||| ...|| . . | . . .|. ..|.|| . .|| .|| || . ||. ...
keePvvvhCsaGigrtGvlilletalalieaaepvyp.ldivrtmrdqramlvqtasqykfvCeailkvyee
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 59-320 | 3.3e-24 | 80.3 | In-house | 11-260 (267) | alignment | ||
Range on Protein: 59-320
Range on HMM: 11-260/267.0
EFVGMRRFNDFEKM-KAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEK
|| ... | . . . . .||. |. |..|| | .||| | || . . || || ||..| .||. . . || | .| . .
efelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd
GARKcfeYFPSKKGDVMDFEEGGQKISVKCEssvtysfrsDAKANVTATEIVIEgpGEKTRKTTHYHWNDWPDRGV------PAADMAVLELLENARPsk
|. ..| | |. ... . |.. | . .. . |. .. | ... | |... | | . . |||. .
nirl...fwPPkmgqakkyqdltvehsleke.........endyqiitlelkfk..nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnr..
gPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
|.||.||.|.||.|. .... .... .. | . | |||.|| ..| .|...|... .| .
.PlvvacsdGvGrsGtflvidsqleraktegvs.difdflrkirsqriglvdtkeryiyihellaeyae
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 61-322 | 2e-37 | 123.5 | In-house | 22-296 (301) | alignment | ||
Range on Protein: 61-322
Range on HMM: 22-296/301.0
VGMRRFNDFEKMKAFkEAQEAGKNRYKDVGCLDNNRVKLEGPW-----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLL
... .| . . . . ... ||.|.. .|.||. |. .||| |.|. .. |.|| .|.|..|| .||| . .|.|. | |..||
kelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlk
EKGARKCFEYFPSKKGDVMDFEEGGQKISVKCEsSVTYSFRS------DAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----
|. ||..|.|. . . .| . ... .. . |. |. | . .... . .. |||. || ||. .
egtkskceqywpnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvih
ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
. ....||.|||||....|.| . .. ..| | ..| .. .| .. ..| || ....|| |.. .
rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf.qvtkavrrskpgaVtTLeqytsiydvidmylqln
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 63-322 | 8.5e-57 | 187.2 | In-house | 24-280 (290) | alignment | ||
Range on Protein: 63-322
Range on HMM: 24-280/290.0
MRRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHE---YIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGA
... . ... .. .. .. ||||||. |..||.|. .| || ||.. .......| .|.|| || ||| | .. .|| . |.|...| |
ykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk
RKCFEYFPSKKGDVMDFEEggQKISVKCESSVTYSFrsdakanvTATEIVI--EgpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----KGP
|| |.|..... . |.| ..... | |. | . . . . ...|| . .|...|||.|||.. .|||.|..| . |
kkCerYWpeegeeelefge..fevtleeekavdddf........lirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaP
IVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDG--EKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
.|||||||.|||| .. ..|. ..| |..| .. ......|.||. .|| || .|.. ......|.
lvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
|
|||||||||
subfamily_egg_pd | Subfamily egg | 65-341 | 3.6e-40 | 132.5 | In-house | 25-291 (307) | alignment | ||
Range on Protein: 65-341
Range on HMM: 25-291/307.0
RFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKgaRK
| . .. .. . | | | | | | ||||| | . ..||||.| ||..|||| | ||| | .|..|.|| || | .
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er
CFEYFPSKKGDVMDFEEGGQKISvkCessVTYSFRSDAKANVTATEIviEGPGEKTRKTTHYHWnDWPDRGVPAADMAVlelLENARPSKGPIVVHCSAG
| |.| . | . . |. .| . . ..| .|| . |. .. | |. . |. . . | | .| |.||.. |
ceyywpkaesdslvtvpGslrie..n...lkvdskadplfrvtklkl..vGgddeerflehwqg.dvnnssdvysplrv...lrklrnlskpvvvqdilG
IGRTGSVVMLEYIMDQLLAGQIIDDG-EKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKkLMEETGVQEAYDAFLEQY
. .....| .| . .|| | | . | .| .|. |... .||||....| .|| . .. |. .||..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv.igsakeldvdyerwleer
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 66-321 | 5.1e-43 | 142.2 | In-house | 35-298 (300) | alignment | ||
Range on Protein: 66-321
Range on HMM: 35-298/300.0
FNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW--PHEYIHANYVATP--TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARK
. .... | ..| |||.||| ..|||.| ..|| | . .. .. . .| .|.|||.|. ||| | ....|. | || . |.| |
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek
CFEYFPSKKGDVMDFEEGGQKisvkcessVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------------R
.|.|||... | | | || |..|... .| . . | .. |. | ..||||.||| |. ||. .
sfkyfPkleskkktvefgkfk........vttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk
PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
|| |..||||||.|||| ... . .. | .. || .|.| ..|||| .|| ||| ||..|...|...
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 69-317 | 3.6e-45 | 149.1 | In-house | 32-275 (314) | alignment | ||
Range on Protein: 69-317
Range on HMM: 32-275/314.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEY
|| | |. .. |||..|. |. ||.| .| .|| |... . ..|. || || ||..| .||| . |... | || .| |.|. || .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky
FPSKKGDVMDFEEggqkISVKCESSVTYSFRSDAKANvtateivIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAG
.| . |.. |..| . | . . .. . |..|. .... ||| .|| ..|.|. . ...|.||||||||
WPedtevygdikv....elvetellaelvvrifrvek.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaG
IGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILN
|||| .... ..| . ...| .. ..|... | ..| || |...|||.
aGrtGtfiaidivldmieregvvdv.fnavktlrsrkvnmveteeqykfiydvile
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 69-321 | 4.6e-42 | 139.0 | In-house | 38-281 (315) | alignment | ||
Range on Protein: 69-321
Range on HMM: 38-281/315.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEY
. .. |. .. |||| .. |. ||.| | .|. ||.. . ..|.|..|.|. . ||| . ..... | || || |. ||. .|
lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky
FPSKkgdVMDFeeGGQKISVKCESSV-TYSFRSDakanvtatEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR----PSKGPIVVHCSA
.| | . . | .. | | |. |. .| |.. |. .|. ||| |||. .....| ... | |.|||||||
wpdk...kviy..Gkitvtrkseevnteytvrtl........svvf...gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa
GIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
|.||||. . |. ..||. | ..|| ... ..|..| . .|. .|| |.....|. |
GvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalletfvc
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 70-319 | 3.9e-36 | 119.8 | In-house | 38-288 (325) | alignment | ||
Range on Protein: 70-319
Range on HMM: 38-288/325.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEyIFMLCNLLEKGARKCFEYF
.|. .. |||.|.| ||..|| || |. .|| |.|. . . . |. .|||| .| |.| . .. . . .. | |..| .| |.
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrcavyw
PSKKGDVMDFeeGGQKISVKceSSVTYsfrSDAKANVTATEIVIEGpgeKTRKTTHYHWNDWPDRGVPA---ADMAVLELL----ENAR---PSKGPIVV
| . |. | || ..... . .. || | | .| .|| ... |.| ||. . ...|.|. | . . .||.|
pkemgksktf..Gglevklr..tieei...sdyvhrvldvkqvkkG...etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv
HCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYF
|||||.|||| . | ...... .| . . |.|..| . ..| || .... . ...
hcsaGvGrtGvfislysalakvieesrvdifg.fvkklrkdrpsmvetvdqyiliyealveay
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 70-237 | 7.7e-09 | 29.5 | In-house | 86-239 (244) | alignment | ||
Range on Protein: 70-237
Range on HMM: 86-239/244.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGarkcfEYFPS
|| . ... ||| .| ||| | .| || | .| .| || || | ||| | . .|. . .| . |. ||.|
svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpd
KKgdVMDF-EEggqKIsvkcesSVTYSFRSDAKaNVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAAD
. ... || | .|| . | . | |. |... || | . | . .|| | |
se..plewyee...di......tvtltdrdefk.nikasnleiesdmneshqaltmfqisnwpsdgttpnd
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 71-325 | 2.8e-56 | 185.7 | In-house | 36-277 (288) | alignment | ||
Range on Protein: 71-325
Range on HMM: 36-277/288.0
KMKAFkeAQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKK
...| ... ..||... . | ||||. |. ||.|| |.. ...|.||.||||. | .| | . |||| |||.||||| .| ||||||.
iidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl
GDVMDFEEGgqkisvkceSSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
|. . . .|. |.| . |. . . |. .||.. . |...|.| ||| .. | ||| . . |||||.|||.|||| ...
Gekarigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlil
LEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLM
....| . ...| | ||.| ..||| |||.||...|... ||
ilialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvleelllkkyk
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 71-322 | 1.8e-46 | 153.0 | In-house | 28-272 (281) | alignment | ||
Range on Protein: 71-322
Range on HMM: 28-272/281.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYF
.|.. . |||| .. ||| ||.|. | .||||||. .| . .| || | ..| |||| | .|.. | |||..|| || |||
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf
PSKKGDVMDFEeggqKISVKCESSVTysfrsdAKANVTaTEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTG
| . ...|. |.||. | | |. || | . . || || ||. |..||| || . .|..| . | | |.|||||.||.|
prnahcclqfd....klsvsyedstv......nkslvt.trlnlsyege.trlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsg
SVVMLEYIMDQLLAGQIIDDGEKILVKIRE-QRNNSIQTDAQYLFVHQVILNYFRKK
... .| .. . . . | ..|. ..| | |.|| ||... .|.|..
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 71-321 | 5.6e-45 | 148.5 | In-house | 35-279 (315) | alignment | ||
Range on Protein: 71-321
Range on HMM: 35-279/315.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFP
. .. .| .. |||||.. ||..||||| ..|| | |. . . | .|..|.||. . ||| | .|.|| | |. .. | || |.|
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP
SKKGDVMDFeeGgqKISVKcessvTYSfrSDAKANVTATEIvIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIG
.|.| ..| | .|.|. . | .| .. .| .. . .|..|. | .....|||.||. ..|.|. . . ..| ...||||||.|
drkadsvef..G..sikve.....lls..leadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvG
RTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
||| |. .. ...|. .. .| ... ..|..| .||. .| |.....|...
rtGvvisidevvaqikrtrsvdvf.nfvknlrakrpylvqteeeyafiydavledllw
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 72-335 | 6.9e-50 | 164.4 | In-house | 24-285 (290) | alignment | ||
Range on Protein: 72-335
Range on HMM: 24-285/290.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG
... |. .. ..|||.|| | |.||| .|| |. | . ...| || || .|.. || | ...| . || ...||. ||..|.|...
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee
-DVMDFEEGGQKISV-KCESSVTYSFRSDAKANvtateivieGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS------KGPIVVHCSAGIG
. . .|. |. . . |.. .| | | ..||. .|.|. ||| ||| . | |..| . | | .|| |.|||||||
ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG
RTGSVVMLEYIMDQLLAGQI--IDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYfrKKKLMEETGVQEAYD
|.|...... .. .. . . | .| |...|..| ||| | | .. ||. |...... ||. .
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG..akvikgdssvqkrwk
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 72-321 | 7.4e-37 | 121.7 | In-house | 30-279 (287) | alignment | ||
Range on Protein: 72-321
Range on HMM: 30-279/287.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKL--EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSK
.|| .| .. |||| || .|..|| | || .|| |||||. |. ..||..|.|. | ||| . .. .. . .. .|.. ||..|.| .
fkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer
kGDVMDFeeGGQKISVkcessVTYSFRSDAkaNVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA--D--MAVLEL---LENARPS--KGPIVVHCSA
| || . . . |. .. . . .|. ....| ... .|||.... . ||. .| || . ||.|||...
.evPmrv..GGysvvl.....ldydikePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv
GIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
||||.| .. . ....|. .| ......||.|. .|. |. .. . . |..
GiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyykt
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 73-320 | 9.5e-48 | 157.7 | In-house | 51-296 (330) | alignment | ||
Range on Protein: 73-320
Range on HMM: 51-296/330.0
KAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSK
.. .. .. |||. .. | .|| | || .|| | .. . ..|| .| |.|.| ||| | .. | | || .| |. || |.|..
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde
kGDVmdfEEGGQKISVK-CESSVTYSFRsdaKANVTatEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP----SKGPIVVHCSAGIGR
| | | ...|. .. .| |. | | |. .. . .|.| . .|.. ||| |||. . .|.||.. . | ||||||||||.||
.Glv...tyGnirvevedetvlvdytvr...kflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr
TGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYFR
||. ..|. ..... | ...| | .. ..| || . .||| || |...|.|.|.
tGtfivldavlervkaerkvdvfe.fvkrlrlqrpqmvqtdeqyefiykvlleyyl
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 74-330 | 4.6e-50 | 164.9 | In-house | 48-301 (310) | alignment | ||
Range on Protein: 74-330
Range on HMM: 48-301/310.0
AFKeaQEAGKNRYKDVGCLDNNRVKLEG--PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkG
|.| .. |||| || |||. ||||. ..||||||| | . |||.| ||..| ||| | .|.. | |..||. |.| || |.|| |
ayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.g
dVMDfEEGGQKISVKCESSVTYSFRSDAKANVTATEIVIEGPGE-KTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
| . | ... .||| . | . | | | | . | . . .| .||||||| . |. .|| |||||||..|.. ||
.vte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvva
LEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETGV
|.. .|.| |. .| |.. ... .| |||. |||....| . . | .. . |. .
lklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifargetevaekil
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 74-318 | 9e-35 | 114.8 | In-house | 39-235 (392) | alignment | ||
Range on Protein: 74-318
Range on HMM: 39-235/392.0
AFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGarkcfeyfpskk
. .. . |||||.. .|..||||| ..|. | |. . | | .|..|.| . ||| | .|..| | |. .| |
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............
gdvmdfeeggqkisvkcessvtysfrsdakanvtateiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTG
|...| . .|. .|||..|| ..|..... . | |...|||||.||||
..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtg
SVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNY
|. .. .. . ...| .....||..| .||. || |.. .|.
vvisidsvvahakktrmvdv.fnfvtnirrkrpymvqtkeqyafiygavled
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 75-319 | 1.7e-60 | 199.9 | In-house | 5-242 (243) | alignment | ||
Range on Protein: 75-319
Range on HMM: 5-242/243.0
FKEAQEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPtnpKRFICTQAPLEKTCAD----FWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPskk
.. . ||||.|. ..|..|||||| . ||.||.. . .|.|.||.||..|..| || |... ....| ||..| |.|. ||..|.|
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...
GDVmDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG--PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR------------PSKGPIVV
|.| ... ..|.. |. . ....| .....| ... || .|||. ||| ||| .|..|. .| .|.||..|
gev.tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV
HCSAGIGRTGSVVMLEYIMDQLlaGqiiDDGEKILVKIREQRNN-SIQTDAQYLFVHQVILNYF
|||||.|||| .... .....| | | |... ..||||.. ..|| || |.....| ..
HCsaGvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeallell
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 76-321 | 3.4e-49 | 162.3 | In-house | 16-266 (270) | alignment | ||
Range on Protein: 76-321
Range on HMM: 16-266/270.0
KEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVA-TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG
. |... |||.|. . ||.|| .|| ||||. ..|..|....||. | .|| | .. ||. | |. .| ||| .|| |.|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk
DVMDFEEGgqKISVkcessvtYSFRSDAKANVTATEIVIEGPGEKTRKTtHYHWNDWPDRGVPAADM------AVLELLENAR-----PSKG-PIVVHCS
. ...|.| ||.| . . . .|.. .| ||. | . |...|.|||.||| .. .|..|.. | .|. |..||||
ekvkledg..kikv.......lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs
AGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
||.|||| ...|.... | . . | .|. ..|..| . .|. || |.......| ..
aGvgRtGtlialDiavrlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveyaer
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 76-319 | 7.8e-48 | 157.8 | In-house | 5-242 (250) | alignment | ||
Range on Protein: 76-319
Range on HMM: 5-242/250.0
KEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARkCFEYFPSKKGD
|. |. |||| |. ||. || || .|| | .. . .. | || ||.||..| ||| | ...|.. | || || |.. . .|.| .| .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae
VMdfeegGqKISVKCESsvtysfrSDAKANVTATEIVIEGPGEKT-RKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTG
| .. |. | .. .|..| ..... .. | ..|. |||.|||. ||||||.. . ..|..|.||||.||.|
ky.....G.dvtvslls.......keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG
SVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
. . .. ....| ...| |.. ..|..| ..... .|| ||...||..
afiaidavlerlkkekvvdv.fkvikvlrkdrphavesleqyvfvyeiilkal
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 76-316 | 6.9e-34 | 112.1 | In-house | 4-238 (239) | alignment | ||
Range on Protein: 76-316
Range on HMM: 4-238/239.0
KEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG
|. . |||| .. | .|| || || .|| |.|. .|| .|.|| .| .. ||| | .|.. | || |.| .||..|.|
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts
DVMDFEEGGQkisvKCESSVTYSFRSDAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGS
.. . | | | |. ..| || | .||. |||.||| ||| | ... | | |.|||||.||||.
kycnlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga
VVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVIL
..... .. | . .| . . |||.| .|| ||.|.| .|
flvidamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavl
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 76-319 | 3.5e-29 | 96.4 | In-house | 38-290 (296) | alignment | ||
Range on Protein: 76-319
Range on HMM: 38-290/296.0
KEAQEAGKNRYKDVGCLDNNRVK---LEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGArKCFEYFPSKKgd
... .|||. .| |.||| |.| .|| | || . . .| .| |.|| ..| .|| . |..... . .|.. . .. .|.| |
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..
VMDFEEggqkISVKCESSVTYSFRSDAKANVT----ATEIVIEGPGEKTRKTTHYHWNDWPD-RGVPAADMAVLELLE-------NA--RPSKGPIVVHC
.. | | |. .. .|. . .| |. .. .|| ..... |. || |..||.. .. .| .||.||..
keqyge....ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs
SAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYF
| | .|.| . .. .... . .| | . ..|..|.. ... .| .. .|.|...
sdGasRsGvylaidanlelvekeeevdvFe.avktlrrsRpqLvenveeYkyiYdvlleav
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 77-322 | 1.5e-28 | 94.5 | In-house | 44-347 (350) | alignment | ||
Range on Protein: 77-322
Range on HMM: 44-347/350.0
EAQEAGKNRYKDVGCLDNNRVKLE-----------GPWPHEYIHANYVATP-----TNPK-RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGA
. |||||.. . .||||. . .|| |||. . ||. ..| ||||| .| ||. .....||. | .| .. | .
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl
RKCFEYFPSKKGDV-------MDFEEGGQKISVKCESSVTYSFR------SDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE-
.|| .|.. . | . . .| . |.. . | . | . . . . |. . ... |.| .. .|. ||
ekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalev
--------NAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQL--------------LAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNY
.|. ||.||||||.|||| .| |.... .. | .. | . |. ..|.|| . .|. |..|... .|.|
kndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
FRKK
|. .
faLr
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 77-235 | 3.3e-28 | 93.4 | In-house | 27-181 (297) | alignment | ||
Range on Protein: 77-235
Range on HMM: 27-181/297.0
EAQE---AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVATPTNPK--RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKK
|. ||||.|. |..|||| . . ..|| |.||. | ... ..|..| ||..| ||| . ... | | |...| | | ||. |.|| .
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv
GDVMDfeeGGqkiSVKCESSvtySFRSDAKANVTATEIVIEGPgEKTRKTTHYHWNDWPDRGVPA
.. . | .| | | || .| ||. . ...|. .| . ||| |||.
qerlk...ag...dvvvefl...sstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvps
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 78-322 | 6.1e-65 | 214.7 | In-house | 31-275 (278) | alignment | ||
Range on Protein: 78-322
Range on HMM: 31-275/278.0
AQEAGKNRYKDVGCLDNNRVKlegpwphEYIHANYVATPtnPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDFe
. ||||||. ..|..||| .||.|.|. .. ||.||.||.||..|.|||| |... ....| ||..|.|.| ||..|.|. |... .
lgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggslty.
eggQKISVKCESSVTYsfRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--MAVLELLENARP-----------------SKGPIVVHC
...|...| .. . . | . .| .. ..|. ||.|. ||| ||| . . .||||| | |.||..|||
...gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC
SAGIGRTGSVVMLEYIMDQLlaGQIIDdGEKILVKIREQRNN-SIQTDAQYLFVHQVILNYFRKK
|||.|||| .|.. .....| .. .| .... ..|.||.. ..|. || |.....| .....
saGvgRtGtlvaaylmlell..eggvd.lleavkelrsqRpglavqnleqyrflyefllelllrg
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 78-320 | 1.7e-44 | 146.8 | In-house | 41-277 (515) | alignment | ||
Range on Protein: 78-320
Range on HMM: 41-277/515.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVM
. |||||.. .|..||||| ..|. | |. . | | .|..|.|.. . ||| . .|..| | |. .| | || .|.| | || .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv
DFeeGgqKISVKcessvTYSFRSDAKAnVTATEIVIEgpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTGSVVM
| | .|.|. . | ... . . . |. |...| | .|...|||.||| ..| |. . . ..| |...|||||.|||| |.
kf..G..sikve.....lvsleactgg.ikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis
LEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
.. .. . ....| ... .||..| .||. || |.....|...
idsvvahakttrmvdvf.nfvtnirqkrpylvqtqeqyafiygavledll
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 78-317 | 2.3e-40 | 133.9 | In-house | 59-289 (319) | alignment | ||
Range on Protein: 78-317
Range on HMM: 59-289/319.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnllekgARKCFEYFPSKKgdvm
|. |||. .. |.|.|||| | .|| | .|. .....| .| ||. | |||| | .. .. | .| || .|.| |
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki....
DFEEGGQKISVKcesSVTYSFRsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSV
. .|. |..|. ||. . | |. .| . || | .|. ||| ||| . .. |... . .||||||||.||||
vikeerfkvkvd...sveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy
VMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILN
..|. ..|.. . .| ... .|.|||. .| .|| |.. .|.
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalle
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 78-317 | 1.4e-39 | 130.7 | In-house | 31-264 (283) | alignment | ||
Range on Protein: 78-317
Range on HMM: 31-264/283.0
AQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVA---TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkGdVM
.. |||.... |..||.|. . ...|| | .. . |..| .|.||..| ||| | ...|. | || .| | || |.|.. | .
denkrknrnqeivpadqwrvelk.sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.G.se
DFeeGGQKISVKCESSVtYSFRSD-AKANVTateivieGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELL-ENA-RPSKGPIVVHCSAGIGRTGSVV
|. | .... | . || .| . ..| .|| .|| . | | . .... . . |||||||||.|||||. .
dy..Geftvtlrketts.nsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi
MLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILN
. ....|. ..| ... .|||| .|| || .||...|.
aasasvkdaltesvvdv.favvkimreqrmmavqtldqyklvhelvle
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 79-320 | 4.1e-64 | 211.6 | In-house | 8-244 (245) | alignment | ||
Range on Protein: 79-320
Range on HMM: 8-244/245.0
QEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMD
||||.|. ..|..|||| . . . ||.|.|| .. ...||.||.||..|..||| |... ....|.||... |.| ||..|.|. |...
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt
FEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
... ..|.. | . ....| ... .. . ..|. .|||. .||| ||| . .|..|| .| |.||..||||||.|||| ..
ygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi
MLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
.. ....|| . . .. |... ..|.|| ...||. || |.....|....
aaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallellk
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 79-317 | 6e-40 | 132.5 | In-house | 24-253 (284) | alignment | ||
Range on Protein: 79-317
Range on HMM: 24-253/284.0
QEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnllekgARKCFEYFPSKKgdvmD
|. |||. .. |.|.|||| | .|| | ... .....| || ||. | |||| | .. .. | .| || .|.| | .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki....v
FEEGGQKISVKcesSVTYSFRsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSVV
.|. |..|. ||. | | |. .| .. || . .|. ||| ||| . .. |... . .||||||||.|||| .
ikeerfkvkvd...sveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi
MLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILN
.|. ..|.. . .| ... ..|.|||. .| .|| |.. .|.
vldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalle
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 79-317 | 7.3e-34 | 112.0 | In-house | 6-238 (239) | alignment | ||
Range on Protein: 79-317
Range on HMM: 6-238/239.0
QEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVM
. |||| .. | .|| || || .|| |.|. .|| .|.|| .| .. ||| | .|.. | || |.| .||..|.|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc
DFEEGGQkisvKCESSVTYSFRSDAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGSVVM
.. . | | | |. ..| || | .||. |||.||| ||| | ... | | |.|||||.||||....
nlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv
LEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILN
.. .. | . .| . . |||.| .|| ||.|.| .|.
idamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavle
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 79-277 | 7.8e-27 | 89.0 | In-house | 46-255 (418) | alignment | ||
Range on Protein: 79-277
Range on HMM: 46-255/418.0
QEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATpTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVmD
... |||| .. .. ||.|. .|| |||. . ||.||||| || .| |||| | ..... | || |. || |.| . | .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.q
FEEGGQKISVKCESSVT-YSFRSDAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------RPS---KGPIVVHCSAGIGR
| |. | || | . .. . .| . || || |.|... |||. .| . .|| . || . ||.||||||.||
fsiygngnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr
TGSVVMLEYIMDQ
||... .| .
tgtfctavimmkk
|
|||||||||
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 79-318 | 4.8e-21 | 69.7 | In-house | 46-278 (303) | alignment | ||
Range on Protein: 79-318
Range on HMM: 46-278/303.0
QEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPTNpKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPsKKGDVMDFEE
.. |||. || ||| .||| ||||.|. .. |. | || || .|.|||| | ..|| ...| | || .. | ..|||
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfee
ggQKISVKCESSVTYsfrsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--------MAVLELLENARPSKgPIVVHCSAGIGRTGSVVM
. | | | .. . .. |. .|...|| .|. . .| . .|. | | .| ||.|. .
..rsirvgefkrvel.......gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal
LEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNY
.| | . | | | | ..|. | ..| .|. .|. .. ..
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 80-321 | 6.8e-67 | 221.0 | In-house | 11-248 (249) | alignment | ||
Range on Protein: 80-321
Range on HMM: 11-248/249.0
EAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDF
||||.|. ..|..|||| .| ... ||.|.|. .. ..|||.||.||..|..||| |... ....| ||..| |.| ||..|.|. |... .
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley
eeggQKISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVV
...|.. | . |...| ... .. ..|. .|... |||| ||| .|...| .| ..||..||||||.|||| ..
....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi
MLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.. ....|| . .| | .. ..|.||....|.. || |.....| ...|
aaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 80-317 | 7e-40 | 131.8 | In-house | 48-277 (439) | alignment | ||
Range on Protein: 80-317
Range on HMM: 48-277/439.0
EAGKNRYKDVGCLDNNRVKL-EGP-WPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEkgarkCFEYFPSKKgDVMDf
. |||||||| .| || | | | || || |||. ..| .| ||.| ..|. ||| . .. |. | ||.||.| . |.||.. .|.
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsda.evcy.
eeGgqKISVKCESSVTYSFRSDAKANVTATeiviEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----ENARPSKGPIVVHCSAGIGRTGSVVML
| |.|... . .| .|| | ..|. |||. ||| ||..| | . ||.|||||||.||||... |
..g..diavrvdrnielpnyvirgfkvfne....rdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiial
EYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILN
. ..|| . . .| . |. .|.||.. .|. .||.|... .|.
dialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 80-321 | 1.5e-36 | 121.0 | In-house | 51-286 (297) | alignment | ||
Range on Protein: 80-321
Range on HMM: 51-286/297.0
EAGKNRYKDVGCLDNNRVKLEGPWPH---EYIHANYVatPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLlEKGARKCFEYFPSKKgdVMDF
. |.|||.. | .||||. . .|. | .| ..| .|.|.|| | . | |||| | ....| | || .. ... .|| |.. | |. |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkg..vttf
eegGqKISVKCESSvtysfrSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
| ..||. .| |. . . . | .| ..| |.. .|||. |. ..|.|... | ..||..|||.||.|||| ..
...G.dvsvvllsv......sereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll
MLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.. .. . . .| ... |.|..| . .||. || ||....|...
tidsvvaeakrekevdif.glvkklrqerpylvqtkeqykfvyvavlealls
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 80-153 | 3.1e-07 | 24.2 | In-house | 37-118 (347) | alignment | ||
Range on Protein: 80-153
Range on HMM: 37-118/347.0
EAGKNRYKDVGCLDNNRVKLEgP---------WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCN
. ||| ||| |. || | | .. || | .. | .| || || .| ||| | . || . . .
slsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 81-312 | 9.5e-51 | 167.3 | In-house | 51-274 (301) | alignment | ||
Range on Protein: 81-312
Range on HMM: 51-274/301.0
AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEgg
|.||. | | . |.. ||||.. |. .|.|||.||.||..|. ||| |. | .|| | ||.. .|| .|| ||.|.| .. .| .
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr..
QKISVKCESSVTYSFRSDAKANVTATEIVIegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA
|| .| . .. | . .|. . . .|| ||| ...|.||||| . . . .|.| .. |. ||||||||||||. . . ||. ...|
fkikiknkelilnkkiskrtlevedstgkf.....atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea
GQIIDDGEkILVKIREQRNNSIQTDAQYLFVH
. |. | | ..||.| |..|| | ..
dptielte.alkhlrehrwngvqtnsqlywmt
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 81-321 | 5.8e-50 | 164.7 | In-house | 44-282 (288) | alignment | ||
Range on Protein: 81-321
Range on HMM: 44-282/288.0
AGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVA--TPTNPKrFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEE
. |||..|. |.|||||.| .|| | .| .|. |. ||.|||||..| .||| | |..|.. | || . |.| |. .|.|..||. . |..
seknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd
ggqkISVKCESSVTYSFRSDAKANVTATeiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--------RPSKGPIVVHCSAGIGRTGSVVM
.|| ..| . . .. . ... . ..... .| ... ||. ||||. .|..|... |.|| |.|||||||.|||| . .
....lsvtlksvretethvervlkletl......dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal
LEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
. .. .| .|... | ... ..|||| ...|. .|. |. ...|.. |.
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 81-316 | 8.5e-41 | 134.7 | In-house | 4-236 (237) | alignment | ||
Range on Protein: 81-316
Range on HMM: 4-236/237.0
AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVmdfEE
|||| .. . | .|| |.|. .|| |.|. ||..|..| ||| .| ||| | .|.| | || |.|. || .|.|| .
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ay
GGQKISVK-CESSVTYSFRSDAKANVTATEiviegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----AR--PSKGPIVVHCSAGIGRTGSVVML
| .|.| | |. || .. . . . | |.. ||||||| |.| . | .. . || ..|||||.|||| ....
gvltvslkkkeefsdytvrslllskrltlk........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi
EYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVIL
. .. | ...| . . | |.| ||| ||.|.||.||
damlrqakekkvvdiyn.yvysieedrpyiiqtkdqyvfihqtil
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 81-323 | 6.4e-36 | 120.0 | In-house | 47-284 (314) | alignment | ||
Range on Protein: 81-323
Range on HMM: 47-284/314.0
AGKNRYKDVGCLDnNRVKLeGP---WPHEYIHANYVATPtnpKRFICTQAPLEKTCADF----------WYMC--YQDKVEYIFM---------------
||||.|. . | |||.| . . ||.|.|| .. ..||.||.||| |. || | | .. .| .| |
rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda
------LCNLLEKGARKCFEYFPSKKgdvmdfeeggqkisvkcessvtysfrsdakanvtateI-------ViegpgekTRKTTHYHWNDWPDRGVPAAD
|..| ..|. ...... | . .| .|.. ..|| ..| .
AlgKtpllildgngneptaadlellk.....................................eelydpelf.......erlgikylripvpDgsaplle
M--AVLELLENArPSKGPIVVHCSAGIGRTGS-VVMLeYIMDQLlagQIidDGEKILVKIREQRN-----NSIQTDAQYLFVHQVILNYFRKKK
. ..||..|.| . .||..|||.||.||||. ||. |.| .| .. . |..| .|..| ..|.. ||.|.....|.|....|
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa.ylmkll...gv..sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 82-317 | 2.6e-72 | 238.4 | Pfam-A | 3-235 (235) | alignment | ||
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEgg
||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..| ||| .|| .|.|..... . ...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..
qkISVKCEssvTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
|.|... . . . ... ... .|. .. ...|.....|...|||.|||. ..|.|... . || ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
QLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILN
|| |.. | .|. ..|.||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 82-317 | 2.6e-72 | 238.4 | In-house | 3-235 (235) | alignment | ||
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEgg
||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..| ||| .|| .|.|..... . ...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..
qkISVKCEssvTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
|.|... . . . ... ... .|. .. ...|.....|...|||.|||. ..|.|... . || ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
QLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILN
|| |.. | .|. ..|.||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 82-323 | 3.8e-45 | 149.1 | In-house | 3-175 (182) | alignment | ||
Range on Protein: 82-323
Range on HMM: 3-175/182.0
GKNRYKDVGCLDNNRvklegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnllekgarkCFEYFPskkgdvmdfeeggq
||||.|. . |..| . ||.||... . ..|||.||.|| .|.|||. | .. .. .| .|. .. |.|
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............
kisvK-CessvtysfrsdakanvtateiviegpgekTRKTTHYHWNDWPDRGVPAaDMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQlla
. . .| ..|.. ||| ||| .|...| .. ..||..||||||.||||..|.. ... .
....ell.............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...
gQiiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
. . |... .|..|.....| || |.....| ... ||
.g..vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 82-331 | 3.6e-42 | 139.3 | In-house | 37-282 (285) | alignment | ||
Range on Protein: 82-331
Range on HMM: 37-282/285.0
GKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNP-KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGG
||| || |... || |. ..||||... | . .| || || .| .|||.| ||.|. |..||| |.| | || |.| | |.|. | .
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye
QKISVKCESSVTYSFRsDAkANVTATEIVIEGPgektRKTTHYHWNDWPDRGVPAADMAVLELL---ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQ
.. | ... . .| |. || | | . |||. | ..|| .. | . ||.||||||.||| ..| ..| .
itlteckeeaiagtil.na.ltvintedassep....lymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatir
LLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETGVQ
.. |. |. ..| | ...|. |.||.. |...|| . ..| ||
imenpniem.ldivremramrfqavqshmqflflyvvlmeyfigegvvertgqi
|
|||||||||
subfamily_eak_pd | Subfamily eak | 83-235 | 4.3e-10 | 33.5 | In-house | 55-196 (332) | alignment | ||
Range on Protein: 83-235
Range on HMM: 55-196/332.0
KNRYKDVgCLDNNRVKLEGP--WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFeeGg
.| .| | | . |.| . || | . . ...| | .. |. || | .. | | .| . .|.. | ||| | ....| |
rnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf..G.
qKISVKCESSVtysfrsdaKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA
.. |.. . | | |. | .. |..| . ||. | . .|
.ildverkefv........krniletrllelskGnethrvlhykvfGwtettlpk
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 89-333 | 7.4e-34 | 112.2 | In-house | 27-262 (290) | alignment | ||
Range on Protein: 89-333
Range on HMM: 27-262/290.0
VGCLDNNRVKLEG---PWPHEYIHANYVATPTNpKRFICTQAPLEKT-------CADFWYMCYQDKVEYIFMLCNLLEKGAR----KCFEYFPSKKGDVM
| . ..|| |.| .|||||.| | . |.| ||.|.||. .||.| |.||. . |||. || | | .|.| . |. .
vpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel
DFEEggqkISVKCessvtysFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyI
|. ..||| .. .| |.|.. .|. . ||. ..| .. |. .|.|... . || |..||| || | . .. .
kfkg....ltvkC.......kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.l
MDQLLAGQ-IIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILnyfrkkklmeeTGVQEA
|..|.. |..| ..|.||.. |... .. || .|. ..|.
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...........llaiev
|
|||||||||
subfamily_Cele-PTP-2_pd | Subfamily Cele-PTP-2 | 93-213 | 2.8e-07 | 22.4 | In-house | 58-178 (327) | alignment | ||
Range on Protein: 93-213
Range on HMM: 58-178/327.0
DNNRVkLEGPwPHEYIHANYVATptNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNL---LEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCES
|| || | | |.. .|| . .| ||| .|. | . .|.. . || ||. |||.. . |. | .|. |..
dnrrv.lcgs.deeffpgqyvrm..egaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsivcka
SVTYSFRS-DAKANVTATEIVIEGP
|. . . ..| .|.||.
reglsmgatkyeleltdsevvidkn
|
|||||||||
subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 95-232 | 7.3e-07 | 23.6 | In-house | 8-125 (130) | alignment | ||
Range on Protein: 95-232
Range on HMM: 8-125/130.0
NRVKlegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGarkcfEYFPSKkgDVMDFEEggQKISVkcessvTYS
.|.. ..||.|..| . . .. ||.|| .|. ||| | . |. . .| . |. ||.| . ... | ..| | | .
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds..ePlewye..ediiv......tlt
FRsDAKANVTATEIVIEGPGEK-TRKTTHYHWNDWPDRG
| | |. |... || . . | .. .|| |
dr.defknikasnleiesdlneshqaltmfqisnwpsdg
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 98-322 | 4.6e-31 | 103.2 | In-house | 11-174 (178) | alignment | ||
Range on Protein: 98-322
Range on HMM: 11-174/178.0
KLEGPWPHEYIHANYVAtptnPKRFICTQAPlektcADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdvmdfeeggqkisvkcessvtysfrs
.|||.. .||.|... | ..... | ||.. . .. .. .| .|.. || | ||..|.|.. |
nleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................
dakanvtateiviegpgektrktTHYHWNDWPDRGVPA---ADMAVLELLENAR-PSKGPIVVHCSAGIGRTGSVVMLEYIMDQllagQIidDGEKILVK
.|.. .|| ||| ....|..|.|. ...||..||||||.||.|..|.. ... . .. . |...
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl..sleeaiel
IREQRNnSIQTDAQYLFVHQVILNYFRKK
.||.|. .... |. ..... | .. ..
vrerRp.ivpnpgqlrqLyefelrllkes
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 99-167 | 1.4e-11 | 38.3 | In-house | 84-154 (349) | alignment | ||
Range on Protein: 99-167
Range on HMM: 84-154/349.0
LEGPWPHEYIHANYVATPT--NPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFP
.. ...|| |||. . |..|.||||| | ||. . ..|. .. | . |.. .|| |.
sdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 101-320 | 1.2e-39 | 131.2 | In-house | 8-174 (176) | alignment | ||
Range on Protein: 101-320
Range on HMM: 8-174/176.0
GPWPHEYIHANYVATPtnpkRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMdfeeggqkisvkcessvtysfrsdak
... ||.||..... |.|.||.||..|.|||. | .. .......|... |.| ||. |.| .. .
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................
anvtateiviegpgektrkttHYHWNDWPDRGVPAAD--MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyimdqLLAGQIIDDGEKILVKIREQR
.|.. .||| ||| . . .||....|. ..||..||||||||||| .|.. || . . |..| ..||||
.....................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqR
N-NSIQTDAQYLFVHQVILNYFR
...||..|| |.....| ...
plgavqtpeQyrflyefellllk
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 105-313 | 2.1e-38 | 127.1 | In-house | 5-155 (172) | alignment | ||
Range on Protein: 105-313
Range on HMM: 5-155/172.0
HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLlekgarkcfeyfpskkgdvmdfeeggqkisvkcessvtysfrsdakanvt
. ||.|.|. .. |.|||.||.|| |.|||| |... .. .|..|..|
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................
ateivIEGPGEKTRKTTHYHWNDWPDRGVPaADMAVLELLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllaG-QiidDGEKILVKIREQR
| .| .|.. ||| ||| .||.|| |. ..||..||||||.|||| .|.. ... . |... .||.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl...sleeavalvrekR
NNSIQTDAQYLFVHQ
....|.. || |...
pgavqnpsqyrflyy
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 105-313 | 1.4e-37 | 124.4 | In-house | 2-164 (174) | alignment | ||
Range on Protein: 105-313
Range on HMM: 2-164/174.0
HEYIHANYVATPTNPKRFICTQAPLEktcadFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkgdvmdfeeggqkisvkcessvtysfrsdakanvt
. ||.|... ..|.|..|.||. ||.|... ......||... |.| ||. |.|.
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................
ateivieGPGEKTRKTTHYHWNDWPDRGVPAADMaVLELLENARPS-----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLagQIIDDGEKILVKIREQRN
. .| .|.. |||.||| .. .||... .. .||..||||||.|||| .|.. ... .|| . .| ... ..| ||
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp
NSIQTDAQYLFVHQ
...||. || |...
gmvqtpsQyrflyy
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 105-250 | 1.6e-22 | 74.6 | In-house | 56-193 (319) | alignment | ||
Range on Protein: 105-250
Range on HMM: 56-193/319.0
HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkgdvmdfeEGGQKISVKCESSVTYSFRSDAKANV
||..|.|| . . | .|..|..||.. .||| . .. . | |..| |.| ..| ||.|.| |... |. . || | . .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk........etldntslyGdilvtlkgrevkdrya
TATEIVIEGPGEKTRKTTHYHWnDWPDRGVPAADMAVLELLENARPS
..| .. . .|..|. ||| . .|.. .||| . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 106-342 | 4.4e-49 | 162.8 | In-house | 5-248 (272) | alignment | ||
Range on Protein: 106-342
Range on HMM: 5-248/272.0
EYIHANYVATPTN---PKRFICTQAPLEKTCADFWYMcYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKIS-VKCESSVTYSFRSDAKA
||.|..| .... |.|......||. |.||||.. .. .. .|..|... |.|. ||. | | . ...... . . . . ..|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy
NVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADmaVLELLENARPsKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDD-------GEKILVKI
.. ..... . ...|. .|.|. ||||.||| .||||| . .||..||||||..||| ||.| ... .. . .|.|| |... ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel
REQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETGVQEAYDAFLEQYK
|.|| ...||..||||.....|...|. ... .. |.||. |.|
raqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyG
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 106-315 | 1.4e-29 | 98.0 | In-house | 4-149 (151) | alignment | ||
Range on Protein: 106-315
Range on HMM: 4-149/151.0
EYIHANYVATPtnpkrFICTQAPLEktcaDFWYMCYQDKVEYIFMLCNLLEKGarKCFEYFPSKKgdvmdfeeggqkisvkcessvtysfrsdakanvta
||...|| ......||. ||. . .. .. .|..|... | | .| ||.|.
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................
teiviegpgektRKTTHYHWNDWPDRGVPAADMAVLELLENARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQllagqiiDDGEKILVKIREQRNNSIQT
.. .|... |||| |.| ||||.|| .. .||..||||||.|||| .|.| .. . . |..| .|..| ...|.
............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp
DAQYLFVHQVI
|.||.....
nqqflfqlfal
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 117-313 | 2e-33 | 110.6 | In-house | 6-144 (152) | alignment | ||
Range on Protein: 117-313
Range on HMM: 6-144/152.0
TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFpskkgdvmdfeeggqkisvkcessvtysfrsdakanvtateiviegpgek
.|..||.||.|.. |.|||| | .. .. .| ||..|||.| || .|.
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................
trkttHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllagqIIDDGEKILVKIREQRNNSIQTDAQYLFVH
.|.. ||| ||| .. .|.||. |. ..||..||||||.|||| .|.. ... . |... .||.|...... |. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
Q
.
e
|
|||||||||
subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 120-313 | 1.2e-11 | 39.1 | In-house | 4-197 (198) | alignment | ||
Range on Protein: 120-313
Range on HMM: 4-197/198.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLE-KGARKCFeYFPSKKGDVMDFeeGgqKISVKCEssvTYSFRSDAKA-NVTATEIVIEgPgEKT
.|.|.|| || .| |||| | .. .| |. . | | | |.|. . . . | .|| .. | . ..| . |. . | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..g..slsvttk...tittkpdytitaliltnntta.p.pst
RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL-LAGQIIDDGEKILVKIREQRNNSIQTDAQYL
|. .|| . | .. | . | .. | |..|||| | | || | |. . . . | .. ..|. | | . .|
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn
FVHQ
|..|
fiyq
|
|||||||||
subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 120-313 | 1.3e-11 | 39.0 | In-house | 5-198 (199) | alignment | ||
Range on Protein: 120-313
Range on HMM: 5-198/199.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLE-KGARKCFeYFPSKKGDVMDFeeGgqKISVKCEssvTYSFRSDAKA-NVTATEIVIEgPgEKT
.|.|.|| || .| |||| | .. .| |. . | | | |.|. . . . | .|| .. | . ..| . |. . | |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..g..slsvttk...tittkpdytitaliltnntta.p.pst
RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL-LAGQIIDDGEKILVKIREQRNNSIQTDAQYL
|. .|| . | .. | . | .. | |..|||| | | || | |. . . . | .. ..|. | | . .|
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn
FVHQ
|..|
fiyq
|
|||||||||
subfamily_hpo-7_pd | Subfamily hpo-7 | 125-332 | 3.1e-21 | 70.5 | In-house | 39-242 (263) | alignment | ||
Range on Protein: 125-332
Range on HMM: 39-242/263.0
TQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEggqkISVKCESSVTysfrsdakANVTATEIVIE--GPGEKTRKTTH
... | .| . |. . | | | . |||. |.| || .||| .| . . ... ..| . .. . |. ... | ||.. .|
lysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan....vnvcttkvqs........dvllktlellstlgeKkkthtvkh
YHWNDWPDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLL----AGQIID-DGEKILVKIREQRNNSIQTDAQYLFVHQVILN
| .. |... | .|..|. || || ..|||||.||||. . .. | . ... . .. | ..| ..|..|. .|.| | | ..|.
ysykgWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
YFRKKKLMEETG--VQE
.. . .| ||
fvlnnfakgeleakyqe
|
|||||||||
subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 126-331 | 1.3e-26 | 87.8 | In-house | 97-295 (302) | alignment | ||
Range on Protein: 126-331
Range on HMM: 97-295/302.0
QAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQK-ISVKCEssVtYSFRSDAKANVTATEIVIEGPGEKTRKTTH-Y
| .|. .| . | .| . ||.. |.. .|| ||. | |... | . | .||| . . | .... . || | .|..|| .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd..l.eeftdkksfklytveiknekkkkkvkktvdil
HWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVIlnyfrKKK
.. ||| | |. . |..| | ..||||||.||||..| . | . || . . . | .|.. .|. | ..|.. | ... .. |
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv.....tkg
LMEETGVQ
||| .||
lmekagvl
|
|||||||||
subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 130-328 | 4.1e-25 | 83.3 | In-house | 38-230 (255) | alignment | ||
Range on Protein: 130-328
Range on HMM: 38-230/255.0
EKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEggqkISVKCESsvtysfrSDAKANVTATEIVIE-GPGEKTRKTTHYHWNDW
| . |. . | | | . |||.. |.| || .||| .| . . ... ..| . | |. . . ||. . | ||.. .||... |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGW
PDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
... | .|..| .| || ..|||||.||||. . |. |.. ... . .. | ..| ..|..|. .|.| | | ..|... |.
ieknaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg
LMEET
.|.
eleak
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 130-341 | 3.3e-10 | 33.1 | In-house | 128-331 (346) | alignment | ||
Range on Protein: 130-341
Range on HMM: 128-331/346.0
EKTCADFWYMCYQDKVEYIFMLCNlLEKGARKCfeyfpskkGDVMDFEEGGQKISVKCESSVTYSF-RSDAKAnvTATEIVIEGPGEKTRKTTHYH--WN
| ||||| ||.... .... .| ... |.|| . . | . | | . |.. || . |.| |.
esfvedfwymiyqeqihlvylmvp.ddklkntt........tslfndenggyqytgkmfinnrradvsgdpke..ytievlpegnsdsvicqvhhhapwk
--DWPDRGVPAADMAVLELLENARPSKGPIVVhCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKL
. | . .| | | |. . | || | ||. | . | ..|| | | . .|. .|..|| .... ||| .. ....| .|.
hlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnng.iepniceimknikqqrpggvesfaqyasiyaivfdyiarkrg
MEETGVQEAYDAFLEQY
.. |. . |...
gkkapvnkdinrfidel
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 190-322 | 1.1e-09 | 32.3 | In-house | 200-341 (347) | alignment | ||
Range on Protein: 190-322
Range on HMM: 200-341/347.0
SVTYSFRSDAKANVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMAVLELL----ENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL
.|. |. . | . |.| || | | . | || . | || |. .. .| . |.|| | |. |. .||. |..|.
avevdqrnknwmnkytvevvaegcseatf.akvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqv
LAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
|.|. | .... |.|.|| . | . . | |.. |
ldgkt.pdcddlfkkmrdqragvftmsifytyairaalfylklk
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 199-318 | 2.4e-22 | 74.6 | In-house | 26-142 (145) | alignment | ||
Range on Protein: 199-318
Range on HMM: 26-142/145.0
AKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQllaGQiiDDGEKILVKIR
.. ..|. . . .|. ..|.. .|||.||| . ...||..|.|....||..||||||.||||..|.. |.| . . . |..| ..|
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll...lg..vsleealelvr
EQRNNSIQTDAQYLFVHQVILNY
.|| ...... |. |.....| .
sqrpgavpnpgqlrflyefelel
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 216-318 | 2.6e-16 | 54.0 | In-house | 87-193 (440) | alignment | ||
Range on Protein: 216-318
Range on HMM: 87-193/440.0
KTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLF
..| .||.. |||.||| ||..... ..||..|||||| |||| .. .. |. . . || .. .|..| . .|| || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyaf
VHQVILNY
||...|.
vheavleg
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 217-313 | 2.6e-20 | 68.1 | In-house | 46-139 (144) | alignment | ||
Range on Protein: 217-313
Range on HMM: 46-139/144.0
TRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllAGQiiDDGEKILVKIREQRNNSIQTDAQYLFVHQ
.| ..|.. .|||.||| . ..||..|.|....||..||||||.||||..|.. .. . . |..| .|..| ...... |. |...
eregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgqlrfLle
|
|||||||||
PTEN_1 | 217-270 | 5.4e-08 | 27.9 | In-house | 91-149 (196) | alignment | |||
Range on Protein: 217-270
Range on HMM: 91-149/196.0
TRKTTHYHWNDWPDRGVPAADMAV--LELLENARP---SKGPIVVHCSAGIGRTGSVVM
.. |. ...| |.| .. .. ..... ... ..||| ||.||.| ||.
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
|
|||||||||
Y_phosphatase3 | Tyrosine phosphatase family | 217-271 | 6.1e-06 | 21.3 | Pfam-A | 94-144 (164) | alignment | ||
Range on Protein: 217-271
Range on HMM: 94-144/164.0
TRKTTHYHWNDWPDRGvPAADMAVLELLENarpSKGPIVVHCSAGIGRTGSVVML
.... . . .. ... .| .|||.| . ..||...||.|| ||| |..|
aeeamaeayreilede.kkayrkvlealae...eegpvlfHCtaGKDRTGvvaal
|
|||||||||
PTPc_DSPc_SM00012 | 220-316 | 8e-30 | 98.5 | In-house | 2-104 (105) | alignment | |||
Range on Protein: 220-316
Range on HMM: 2-104/105.0
TTHYHWNDWPDRGVPAADMAVLELLENARPSKG------PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQ
.|||...||| ||| ..||||.. . .| |.|||||||.|||| .|.|.....|| ... .| ..|. ..|.||....||..||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
VIL
..|
all
|
|||||||||
0038934 | (Phosphotyrosine protein) phosphatases II | 220-308 | 1e-08 | 30.6 | In-house | 67-166 (194) | alignment | ||
Range on Protein: 220-308
Range on HMM: 67-166/194.0
TTHYHWNDWPDRGVPAADMAVLE------------LLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQLLAgqiidDGEKILVKIREQRNNSI
.. |. ......|. .. . . |. .. ..| ..||| ||.|||| .| |.. | . |. . .|| |...|
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.....saeeAialfrekRpgai
QTDAQY
.. ..
pnqdyl
|
|||||||||
subfamily_PTPDC1_pd | Subfamily PTPDC1 | 223-318 | 4.2e-10 | 34.4 | In-house | 85-175 (182) | alignment | ||
Range on Protein: 223-318
Range on HMM: 85-175/182.0
YHWNDWPDRGVPAADM--AVLELLENARpSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLagqiidDGEKILVKIREQRNNSIQTDAQYLFVHQVILNY
.. |.| ||.. . . ... | ..| . ||| || |||| .. . . | ..|| . ..|..| .|||| | .|.. |
vynfgwkDygvasleriLdivkvvafal.qegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksiqtreqvelvkefalfl
|
|||||||||
subfamily_DSP19_pd | Subfamily DSP19 | 229-298 | 2.1e-08 | 28.6 | In-house | 67-130 (152) | alignment | ||
Range on Protein: 229-298
Range on HMM: 67-130/152.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQLLAgqiidDGEKILVKIREQR
|. . . ..|. .|.|| ..| ..|||.||. |. |||. |.| . . . |. | ..||.|
petdllsylkealdFieearskdgavlvHCnAGvSRsasvvi.aylmkkeel.....sleealelvrear
|
|||||||||
subfamily_DSP1_pd | Subfamily DSP1 | 229-277 | 6.6e-07 | 23.6 | In-house | 73-120 (163) | alignment | ||
Range on Protein: 229-277
Range on HMM: 73-120/163.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
|. . . . |.| ..... ..| . .|| ||| | ..... |.| .
pkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla.ylmkt
|
|||||||||
subfamily_CDC14_pd | Subfamily CDC14 | 233-277 | 3.5e-07 | 24.4 | In-house | 246-288 (328) | alignment | ||
Range on Protein: 233-277
Range on HMM: 246-288/328.0
VPaADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
.| |. | ..|| | ..| |.||| ||.||||... |.| .
tP.sdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkh
|
|||||||||
PTPc_motif_SM00404 | 239-276 | 2e-08 | 29.2 | In-house | 68-104 (140) | alignment | |||
Range on Protein: 239-276
Range on HMM: 68-104/140.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMD
.||. .|||. ..| ..||| ||. |...... |.|.
kvldfienaekkggkvlVHCqaGvSRSatliia.Ylmr
|
|||||||||
DSPc | Dual specificity phosphatase, catalytic domain | 239-277 | 2.6e-08 | 28.8 | Pfam-A | 61-98 (133) | alignment | ||
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |...... |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
|
|||||||||
DSPc | Dual specificity phosphatase, catalytic domain | 239-277 | 2.6e-08 | 28.8 | In-house | 61-98 (133) | alignment | ||
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |...... |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
|
|||||||||
subfamily_DSP23_pd | Subfamily DSP23 | 240-313 | 7.9e-07 | 23.8 | In-house | 73-140 (148) | alignment | ||
Range on Protein: 240-313
Range on HMM: 73-140/148.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqiiddGEKIlVKIREQRNNSIQTDAQYLFVHQ
....|.| . . ||| | ||||... .. . || .| | ..|..| |..| | |..
fvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaa.....aeai.aevrrlrpgsvetveqeklvrd
|
|||||||||
subfamily_DSP8_pd | Subfamily DSP8 | 240-320 | 8.4e-07 | 22.7 | In-house | 82-152 (159) | alignment | ||
Range on Protein: 240-320
Range on HMM: 82-152/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQLLAGqiIDDGEKIlvkIREQRnNSIqtDAQYLFVHQViLNYFR
.| .. |. ..| ..||. ||| | .|. . ||| .| . .|. . ..|.| ..| . .. |. |. |.| .
svefidkaksengrvlvhvlaGisrsatva.iayimktlems..ldeayrf...vkekr.pti..spnlnflgqL.leyek
|
|||||||||
subfamily_DSP10_pd | Subfamily DSP10 | 240-277 | 7.5e-06 | 19.9 | In-house | 81-117 (159) | alignment | ||
Range on Protein: 240-277
Range on HMM: 81-117/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQ
|| .|.|| . ..||| ||| | .|| . |.| .
alefieearkkgsrvLvhCqaGisrsatvv.iaYlmkh
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 241-317 | 7.4e-16 | 52.9 | In-house | 218-293 (297) | alignment | ||
Range on Protein: 241-317
Range on HMM: 218-293/297.0
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILN
|| |. . | . ...||||||.||.| ||. . |...| . | | || ..|||| .|| |. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlk
|
|||||||||
subfamily_DSP6_pd | Subfamily DSP6 | 241-278 | 4.6e-06 | 20.2 | In-house | 83-119 (158) | alignment | ||
Range on Protein: 241-278
Range on HMM: 83-119/158.0
LELLENARPSKGPIVVHCSAGIGRTGSVvMLEYIMDQL
.|....|| .| ..||| ||| |. | .| |.| .|
iefidearskkskvlvhClaGisrsvtv.tlaylmkkl
|
|||||||||
subfamily_eak_pd | Subfamily eak | 247-323 | 1.5e-08 | 28.4 | In-house | 233-309 (332) | alignment | ||
Range on Protein: 247-323
Range on HMM: 233-309/332.0
ARPSKGPIVvHCSAGIGRTGSVVMLEYIMdQLLAGQIIDD--GEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
. || ||. .. | |.| |... .. .|. ... . |....|....|. |. .. |. |.....|.|.....
tppsfapii.qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 248-320 | 7.4e-14 | 46.1 | In-house | 244-316 (319) | alignment | ||
Range on Protein: 248-320
Range on HMM: 244-316/319.0
RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
| |.||.||||| |.|||| |. . . .| . | ... .|..| ....| || |...|. .| .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 251-322 | 6.4e-08 | 26.3 | In-house | 265-347 (349) | alignment | ||
Range on Protein: 251-322
Range on HMM: 265-347/349.0
KGPIVVHCSAGIGRTGSVVMLEYIMDQ----------LLAGQ-IIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
...|||||| |||| .| |..... . . | |. ..| || . .| ||. .... .|.||. |
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalk
|
|||||||||
subfamily_PTEN_pd | Subfamily PTEN | 254-312 | 2.8e-06 | 22.4 | In-house | 117-173 (184) | alignment | ||
Range on Protein: 254-312
Range on HMM: 117-173/184.0
IVVHCSAGIGRTGSVVmLEYIMDQLLAgQIIDDGEKILVKIREQRNNSIQTDAQYLFVH
.|||| || |||| .. |.. .|| . .. .. ..| . ..... .| .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve
|
|||||||||
subfamily_Sponge-PTP-7_pd | Subfamily Sponge-PTP-7 | 254-316 | 4.6e-06 | 20.9 | In-house | 1-62 (69) | alignment | ||
Range on Protein: 254-316
Range on HMM: 1-62/69.0
IVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKIlVKIREQRNNSIQTDAQYLFVHQVIL
.|||||.| ||||. . . | .. . ...| . . .| | . . .|.|.| .
mvvhcssgtgrtgtfiaimvemarikseklvdifnnv.qymrkcrpmmvmneieyifihdalv
|