Gene C55B7.3 in Caenorhabditis elegans

Synonym: CELE_C55B7.3, C55B7.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP043_AA protein Get Run
CeleP043_AA_38-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 32-323 8.2e-81 267.0 In-house 22-303 (308) alignment 
Range on Protein: 32-323
Range on HMM: 22-303/308.0
VERKQQKKQILKFVQRtlEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLegPWPHEYIHANYVATP--TNPKRFICTQAPL
.  |.  ...||....   . ...|..||  .... . .......  .   ||||||. ..|..||||  . .. ||.|.|| ..   .|..||.||.||
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPl

EKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG-DVMDFEeggqKISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWND
..|..||| |... .|..| ||..| |.|  ||..|.|.. | ... ..    |..|.. |  .       ....| ... ..   ....|. ||.|. .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfhytn

WPDRGVPAADMAVLELLENARPS--KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
||| |||    ..|..|| .| |  .||||||||||.|||| ...|.....|| ... .|  .... |.||||....||  ||||.....| |...|.
WpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd.vfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 33-338 1.9e-199 655.7 In-house 1-305 (305) alignment 
Range on Protein: 33-338
Range on HMM: 1-305/305.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
|.|||||||||||.|||||.|.|||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt

CADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG
||||||||.|||||.||||||||||||.||.|||.||..||..|||.|||||||.|||||..||.||||.||.|..||||||||.||.|||||.||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETgVQE
|||||.|.|||||.||||||||||||||||||||||||||||.|||||||||.|..|||.||||||||||||||||||||||||||||||||..|. |.|
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee.vke

AYDAFL
||.|||
aykafl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 33-319 2.4e-52 173.0 In-house 6-290 (298) alignment 
Range on Protein: 33-319
Range on HMM: 6-290/298.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFND---FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQ
| .. |... |... . .|   |. .||  ... ..    |.... .. .   |||| |.  ||  || ||        .|| | .. . .. . || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

APLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDfeeggqKISVkcessvtYSFRSDAKANVTATEIVIEG-PGEKTRKTTHYHW
|||..| .||| |  ..... | || || |..  |. .|.|... .  .      .|.|          ... .|... ... ..    ||.|.  . |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg......eitv.......sllskeefadlivrklkvskkkeekerevrqlhf

NDWPDRGVPAADMAVLELLENARPS---KG--PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
  |||.|||.   .||.||.. | |    |  |..|.||||.||.|. . .. ..... . | .|   ...  .|..| ...|| .|| |.....|...
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDv.fqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 35-324 1.7e-66 218.9 In-house 8-288 (290) alignment 
Range on Protein: 35-324
Range on HMM: 8-288/290.0
KQQKKQILKFVQRTLEKMPQGLRAEFVG-MRRF--NDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATpTNPkRFICTQAPLEK
  | . . ||   . .| ...|  |..  .. .   .. . | | .  |  ||||||| | |  || |.   . .|.|||||   ...  || || .|..
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG.lka.mfiltqGalkd

TCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEggqkISVKCESSVTysfrSDAKANVTaTEIVIEGPGEKTRKTTHYHWNDWPDR
|  |.| |  |.|| .| |||.|.|.|  || .|.| |.|.|. | |    |.| |  . .     ||.     |  | .    |  |  |..   |||.
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe....itvlcseedd....kdaniikk.tlsvrdkdsGkehklkhlkikswpdk

GVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKL
 |. ...|.| .|   |   ||.||||||||||||. | .|  .. || |. .|  . .   .|. | ||.| | ||| . ...|.. .. | 
svalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlld.lvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_PTPRB_pd Subfamily PTPRB 36-323 1.1e-60 200.1 In-house 7-289 (293) alignment 
Range on Protein: 36-323
Range on HMM: 7-289/293.0
QQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
 ..... ..|... ..   ..  |.  .. ..  ...|| ..|... ||||...   |..||||   ..    .|| |||.   . |. || || || .|
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

CADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkgdvmdfeeggQKISVKCESSVTYSfRSDAKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRG
  ||| |....|.. | || .|.|||  || ||.|..           ..  .  . .||    .. . . .  |. ||  ....||...||.  ||| |
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...........eepvlyGdikvtlv.aeeeledwvirelkiek.ekeerkvrqyhftsWpdhg

VPAADMAVLELLENAR------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
|| .  ..|..... |       ||.|||||||||.||||  . |. .....   ...|    |....||.||. .|| .||.|.||..|...|||.
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi.fgivaelReeRnllvqtekqYifihqcvldllrkke
0051299 (Phosphotyrosine protein) phosphatases II 37-319 5.6e-78 257.6 In-house 6-286 (288) alignment 
Range on Protein: 37-319
Range on HMM: 6-286/288.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTC
. ...||.|...| . . ||..||  .....   ...|..  .   ||||.|. ..|..||||  .    .. ||.|.|. .. ....||.||.||..|.
sveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

ADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-----PGEKTRKTTHYHWNDW
.||| |... .|..| ||..| |.| .||. |.|.  |... ...    |.|.. | ..       ....| ... ..      .....|. ||.|. .|
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnw

PDRGVPAADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
|| |||    ..|..|. .| .    .||.|||||||.|||| ...|.....||.... .|  .... ..||||....||  ||.||....| |.
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.vleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 37-322 3.1e-77 254.2 In-house 7-292 (305) alignment 
Range on Protein: 37-322
Range on HMM: 7-292/305.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMK-AFKEAQE----AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNP-KRFICTQAPLE
 .  . .||.|.|.   . || || |. ..   .  . ||.  |       ||||.|| | |.. |||. | | .|||||||  |  | |||||.| ||.
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld

KTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGgqkISVKcESSVTYSFRSDAKANVTATEIVIEgpGEKTRKTTHYHWNDWPD
.|  .||.|  |.||| | |||. .| |  || .|.|  .|. ...  |   | |. . | .  .  ||. ..|  ..     |...    | .|..|||
qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg...ivve.nvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpd

RGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
|||| . .. ||||   | || ||||||||||||||..| .|||....   .      ...  .|.||  |||.| ||||.|.|.|||| .|
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
0045450 (Phosphotyrosine protein) phosphatases II 37-321 2.9e-75 249.2 In-house 10-306 (307) alignment 
Range on Protein: 37-321
Range on HMM: 10-306/307.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFND--FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYV--------ATPTNPKRF
. ...|..|...| . ..||..||  ......    ......  .   ||||||. ..|..||||  . .    . ||.|.||         .. ....|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkGDVMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG--PGEKTRKT
|.||.||..|..||| |... .|..| ||..| |.| .||..|.|.. |... ...    . |.. |  .       ....| . . ..   . ...|. 
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrtv

THYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKIREQRNNSIQTDAQYLFVH
||.|. .||| |||     .|...| .|       ..||..||||||.||||..... ....|| .....   | .... ..|||| ...|.  || |..
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

QVILNYFRK
...| ...|
eallelllk
subfamily_PTPN6_pd Subfamily PTPN6 38-326 2.4e-53 176.1 In-house 10-304 (306) alignment 
Range on Protein: 38-326
Range on HMM: 10-304/306.0
KKQILKFVQRTLEKMPQGLRAEFVGMRRF---NDFEKMKAFKeAQEAGKNRYKDVGCLDNNRVKL-EGPWPH-EYIHANYVA--TPTNPKRFICTQAPLE
.... .. . . ..  .|.  ||  ...    . ...... | .. . ||||| .   |..||.| |   |  .|| |||.   .... |..| ||  ||
eqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

KTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMdfeEGGQKISVKCE-SSVTYSFRSDAKANVtateivieGPGEKTRKTTHYHWNDWP
.| .||| | .|.. . | |. . .|.|  ||  |.|... . .    |  ...   | |  .| .|.   ...          ....|.  .||...||
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskk........kkkkeerevfqyhfksWP

DRGVPAADMAVLELLENAR--------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
| |||.   |||..||. .         ..|||||||||||||||...... .....    .    | .|.  ..||||.  .||..|| ||...| .| 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

RKKKLME
..|| .|
etkkkle
0040438 (Phosphotyrosine protein) phosphatases II 39-325 4.3e-80 264.6 In-house 3-282 (317) alignment 
Range on Protein: 39-325
Range on HMM: 3-282/317.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCAD
...|..... | .. ..|. ||  .....    .. ..  .  .||||.|. ..|..||||  . .   . ||.|.|| .|  ...||.||.||..|..|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDFeeggQKISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|..| ||..| |.| .||..|.|.  |... .     ...|.. | ..       .|..| ... .|.  ....|. ||.|. .||| |||
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvp

AADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLM
     .|..|| .| .    .||..||||||.||||..........||  .. . | |... ..||||....|| .|| |.....|.|...|  .
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0043336 (Phosphotyrosine protein) phosphatases II 39-319 1.1e-71 236.9 In-house 5-277 (278) alignment 
Range on Protein: 39-319
Range on HMM: 5-277/278.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDfEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCAD
|..||.... | .....|..||  ...|.  . .. ..  .   ||||||. ..|..||||.      .. ||.|.|| ..  |..||.||.||..|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPskkGDVMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|. | ||..| |.|  ||..|.|   |... ...    ..|.. .  .       ....| . . ..     ..|. ||||. .||| |||
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvp

AADMAVLELLENARP----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
     .|..|. .|     |.||..||||||.|||| ...|.....||  .. .|  |... ..|||| ...||. || |.....| |.
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN9_pd Subfamily PTPN9 40-324 4.3e-57 188.4 In-house 2-295 (297) alignment 
Range on Protein: 40-324
Range on HMM: 2-295/297.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.| ..|.   ||  .||. |.. .|. .   ...|.|   .  ||||.|| |.|. ||.|.   .    .||.||.|    ..| || || ||.||. ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEeggqKISVKCES---SVTYSFRSdakanVTATeiviEGPGEKTRKTTHYHWNDWPDRGV
| | ....|  | |   ..|.| .|| .|.|........|     ..||.  .   .  | .|.     ....    .   |..|| ||.    ||| ||
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvsnveveeeedykvrv.....leik....nvkteesrkvthfqflsWPdyGv

PAADMAVLELLENAR-----------------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVIL
| . ...|..||..|                 ||. ||||||||||||||  . |.. ...|   . .|   . . ..|.||  ||||. || | .. .|
PssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdv.vetvkllrtqrafsiqtpeqyefcylavl

NYFRKKKL
.|  ..| 
eyalelka
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 40-344 5.4e-47 155.0 In-house 5-299 (312) alignment 
Range on Protein: 40-344
Range on HMM: 5-299/312.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGPWpHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
 | |.    .   || |  |.  .       .  ||   ..   ||| .. | |  |  | |     |||||.|   |.|.||.|||.|||.||. || .
mikkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwql

CYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdVMDFEEggQKISVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTrKTTHYHWNDWPDRGVPAADMA
.       | .|| ..| |. || .|     |  .|.|.  ...  .  . .    .|  |       .|.   |... |  || |  ||| |.| .  .
alslgstsiillcgfvedgsekcakyisdivg.fvdled..hrvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdscdt

VLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQiIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETgvQEAYDAFLE
 | ||   .  | |.. |||||.||||.....| ..  |   .  ..  ...| .| .|  |... .||... ...|...  | |..    .. .  | |
alrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn..eqewtkfke

QYKKV
 | |.
tyaki
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 40-321 1.6e-42 140.5 In-house 6-280 (287) alignment 
Range on Protein: 40-321
Range on HMM: 6-280/287.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEK-MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWY
.. .||..  .|  .| .  |. . . .. |. .      |   |||....   ||.|| |.|   ..|| | .. .  . |.|| ...|. .|  .|| 
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk

MCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdV-MdfeeGGQKISVKCESsvTYsfrsdAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG-VPAA
.  . .|. | |||.. |.  ..|..|.|..|  | .    |  .|..  |   ..     |.  .   |.  ..  ..... . |.  .|...| |.  
liddrnvtaivmlcqekendeevcyqyWpeeks.vvl....Geyniellnee..vn.....agyierklevknknkagdkqqvkqyqitnWdstgkvtep

DMAVLELLE----NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
   .| . |    . ......||||||...||..  .  .  ...     .||   ..| . | |. .|.|| .|| |. ...|.|   
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPRD_pd Subfamily PTPRD 41-321 6.5e-62 204.9 In-house 10-283 (564) alignment 
Range on Protein: 41-321
Range on HMM: 10-283/564.0
ILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAqEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFW
. ..|..   .  . .  |.  ... . |.. .| |.|    ||||...   |..||.|   ||    .|| |... . ...| .| ||.||..|..|||
lkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW

YMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkGdVMDFeeggQKISVKCESSVTYSFRSDAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPAAD
 |... ... | || .| |||  || .|.|.| |    .    ... |. |......  .  . ... ..       ...|. ...|. .|||.|||   
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety....geltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgvpesa

MAVLELLENAR----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
 ..|.|... |    | .||||||||||.||||  . ........ . . .|   ... ..|.|||  .||  || |.|..||..  .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDi.yqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_PTPRN_pd Subfamily PTPRN 41-315 1.3e-34 114.2 In-house 17-288 (297) alignment 
Range on Protein: 41-315
Range on HMM: 17-288/297.0
ILKFVQRTLEKmPQGLRAEFVGMRRFNDFEKMK-AFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVAT--PTNPkRFICTQAPLEKTCA
.|....  |.. .. |..|. .. ...  .. | . |. . . |||.|.|   |..||||.       ..|| |  .    | .|  .| ||.|| .| |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva

DFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEG-GQKISVKCEssvTYSFRSDAKANVTATEiviegpgekTRKTTHYHWNDWPDRGV
||| | ... |  | .|..| |.| ..| .|.| .  .| .. |       . |.    |  ||    |. ..|         ||  | .|.  ||..||
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcd...dylvrsfylknlqtse.........trtvtqfhflswpeegv

PAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVI
||.  ..||.        |    |||||||.| ||||  .... ....|| |    |    | ..|.||.. ..| .|. |. ...
PasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 42-321 1.9e-44 146.7 In-house 8-285 (290) alignment 
Range on Protein: 42-321
Range on HMM: 8-285/290.0
LKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE-----GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
 .||.    |  .| |..|  .  ..  ....     ..  .||....   |.||. |         ..|||.| |.    . |..| ||.|...| .||
gefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF

WYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkgDVMDFEEggQKISVKCESSVTysFRSDAKANVTATEiviegPGEKTRKTTHYHWNDWPDRG-VPA
| . .|.||  | ||.|  |.|  ||  |.|..  |. ...|   .| .  |....       | .|. ..      ...... |.|.   |.. | |..
WkliwqekvtiivmltniieegkvkCqqYWpds..dtkayge..fsikllneetln..eyierklevknkn.....sagakqsvtqyqitnwdstgkvtn

ADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
    .| . |      .. ...||||||...||..  . ..  ...    . ||   ..| . | |. .|.||  || ...|..|.|. .
pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidv.fqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-328 3.3e-81 267.6 In-house 5-288 (307) alignment 
Range on Protein: 43-328
Range on HMM: 5-288/307.0
KFVQRTLEKMPQGLRAEFVGMRRFNDF-EKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGP-WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
 .|||||.|  | |. ||  . . .     ..||.  ..  ||||.|| | |..|. .. .    .||||||. . ..||.|||.| |||.|  .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama

YQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCESSVTYSFrSDAKANVTATEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAV
 |.||| . |||...| .  || .|.| ..|. . | | .. |||.   . . .   .   |||. ...    ..|.|  .|. |..|||||||  ... 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklap.dedlinvttlkvdw...aqksrtiqhlqwenwpdrgvpqinlta

LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK--KKLMEET
..|||  |  . |.|||||||.||.|..| . ...|...||.   | .|.. ..|.||. .|||.||||..|.|.|.|| .  |.  || 
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 43-331 1.6e-55 183.2 In-house 10-285 (288) alignment 
Range on Protein: 43-331
Range on HMM: 10-285/288.0
KFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
. |...  .  .|.  |.  .  ..  .. .| ..|. | ||||...  .| .||||..       .|| |.|..   . |..|.||.|| .|  ||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

CYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVmDFeeGgqkisvkcesSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMA
 |..|.. | || .|.|.| .|| ||.|...  .  .  |          |||   ... . . . .. .. .  .. ...|.|..  ||| |||.. . 
vyenktstivmltelveggktkCeeYWPdadkpk.ny..G..........svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskap

VLELL---ENARPSK-GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILnyfrkkKLMEETGVQ
.||||   ..| ... |||.||||||.||||  . |. ..|.. . . ||  . .. |.|.||.. .||  || |...|.|      .|.|| ||.
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevll......slieedgva
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 44-322 9.7e-52 170.8 In-house 5-279 (281) alignment 
Range on Protein: 44-322
Range on HMM: 5-279/281.0
FVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
 .... ..  .|.  |. ...  .  .  .| |. .   ||||...   |. |||.   |     .|| ||.|.. ...|..| ||.|. .....|| | 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

YQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdvmdfeeggqkiSVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAV
.. ||. | |. . .|.|  ||  |.| ..             ..|    .  | .. .||.    .. .|  . .||. .. ..  ||| ||||  ...
weqkvsaivmvtreieagklkChrYWPddns............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkel

LELLENA----RP-SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
||  ..     .. .| |.|.|||||.||||. . |. ..... | .   | . .. ..|..||  .|| .|| ||....|... |.
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 45-322 6.3e-52 171.6 In-house 14-286 (319) alignment 
Range on Protein: 45-322
Range on HMM: 14-286/319.0
VQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCY
...  ..  ..|. ||  ..  ... ...  .. .   ||||...   |. ||.|   .|    .|| |... .  . ..|| ||||||.|  ||| | .
lkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

QDKVEYIFMLCNLLEKGARKCFEYFPSKKgdvmdFEEGGQkISVKCESSvtysfrsDAKANVTATEIVIEGPGEK--TRKTTHYHWNDWPDRGVPAADMA
....  . ||..| ||.  |. .|.|...     |||.|. . |. |.        . ....   .. ..   ..  ||. .|.....||| .||   ..
eeessivvmltklveklkvklkkywpeen.....feeyGr.livtleee.......eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

VLELLENAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
.|.||.. |     ...||||||||||.||||. ..|. .....   ...|   ..  ..| |||  .|. .|| |.....|..    
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 51-321 2.6e-51 169.5 In-house 17-282 (318) alignment 
Range on Protein: 51-321
Range on HMM: 17-282/318.0
KMPQGLRAEFVGM-RRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVE
.    | .|.  . |  . . ..|.  |   . |||| ..   |. ||||.   |    .|| |||.   .. | .| .|||| .|. ||| | .. .  
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

YIFMLCNLLEKGARKCFEYFPSKKGDVMDfeeggqKISVKCESSVTYSFRSDAKANVTATEIviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
 | || .. |.| .|.  |.|||.   ..      |. |. ...|..|     . .|| ||       |..|.   ||. .|||.|||.  . .|.|. .
vivmltqeeergkakvhryWPskgsrsyg......klvvelkeevelsdyvlrefkvtrtee......eesrqvrqyhytsWpdegvpesgaslldlvrq

A-----RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.     ....||||||||||.||||  .... ..... | ...|   ..  ..|||||  .||. || |...|.|..   
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvllealas
0036941 (Phosphotyrosine protein) phosphatases II 53-326 2.1e-78 258.9 In-house 12-284 (297) alignment 
Range on Protein: 53-326
Range on HMM: 12-284/297.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|. ||  . ..    ......  .   ||||||. ..|..|||| .. .. ||.|.|| ..  ...||.||.||..|..||| |... .|. | ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NLLEKGARKCFEYFPSKKGDVMDFeeggQKISVKCESSVTYsfrsdAKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP--
.| |.|  ||..|.|...|... .     ...|.. |  ..      ....| ... ..   ....|. ||.|. .||| |||     .|...| .|   
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA--GQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLME
    |.||..||||||.||.|..........||     .   |  ... |.||||....||  ||.|.....|....||...|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0047943 (Phosphotyrosine protein) phosphatases II 53-319 6.1e-75 247.5 In-house 11-272 (273) alignment 
Range on Protein: 53-319
Range on HMM: 11-272/273.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|..||  .... .  ......  .   ||||||. ..|..|||| |. .. ||.|.|| ..  ...||.||.||..|..||| |... .|..| ||.
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

NLLEKGARKCFEYFPSKKGD-VMDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-
.| |.| .||. |.|.. |. .. ...    ..|.. |  |       |...| ... ..    ...|. ||.|. .||| |||.    .||..| .|  
elvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
     |.||.|||||||.||||....|....||| ... .|  .... ..|.|| ...||  ||.|.....|.|.
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 53-320 1.3e-53 177.2 In-house 21-284 (305) alignment 
Range on Protein: 53-320
Range on HMM: 21-284/305.0
PQGLRAEFVGMRRFNDfeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
 .|| |..  . . ..  ...  |. ... |||.|..  ||..|..|        ..|| |.|| .  . |..| .|.||..| ||||.. .. ||. | 
dkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLCNLLEKGARKCFEYFPSKKGDVMDFeeGGqkISVKCESSVTYSFRSDAKANVTATEIviegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN---
||..| | |  ||  |.| .|.....|  |   .||. .|. |.|     | ...  .       ...|  ..|.  |||| |||    ..|.|...   
mltklveggkdkCrqYWpesktekkef..ge..fsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk

-ARPSKG-PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
  . .|| |..||||||.||||  ....  ...| . ...|   ..| ..|..| . .|| .|| |.|... ..  
dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdv.fevlkqlRskrmkmvqtldqYvflhdaldelit
0039614 (Phosphotyrosine protein) phosphatases II 54-322 1.3e-70 233.5 In-house 32-292 (297) alignment 
Range on Protein: 54-322
Range on HMM: 32-292/297.0
QGLRAEFVGMRRFNDfEkMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYI
..|..||  . .... . .. ..  .   ||||||. ..|..|||| ..      . ||.|.|| ..   ...||.||.||..|..||| |... .|..|
tllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

FMLCNLLEKGArKCFEYFPSKKGdvmdfE--EggqkISVKCESSVTysfrsdaKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
 ||..| |.|  ||..|.|.. |     .  .    ..|.. .  .       ....| ... ..  ....|. ||... .||| |||     .||.|| 
vmLtklvelgr.kcaqywpeegg.....tygd....ftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflel

ARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
.|       ..||..||||||.||||..... ....||  .. .|  .... ..||||....||. || |.....| ....|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRG_pd Subfamily PTPRG 54-343 4.7e-52 172.0 In-house 19-314 (563) alignment 
Range on Protein: 54-343
Range on HMM: 19-314/563.0
QGLRAEFV--GMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEY
.|. .||    ..  ..  .... .. ..  |||| ..   |. ||||..       ..|| |||.      | || || ||..|. ||| | .. .|. 
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IFMLCNLLEKGARKCFEYFPSkkGDVMDFEeggqKISVKCESSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE--
| |. || |.|.|||. |.|.   ......    ...|. ... . .  .  .  .  ...  .   .. .. ..||. .||| |||   . ||   .  
ivmitnlvergrrkcdvYWPk..desetyg....alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

-NARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK-LMEETGVQE--AYDAFLEQ
  |...  ||||||||||.||||  ..|. .. |. . ....   ..| .|| |||. .||  ||.|.|...|.  . |.  . .. |.|      .|||
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavn.vfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyleq

YKK
  |
qyk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 54-321 6e-51 168.1 In-house 5-270 (274) alignment 
Range on Protein: 54-321
Range on HMM: 5-270/274.0
QGLRAEFVGMRRFNDFEKMKAFKeaqEAGKNRYKDVGCLDNNRVKLEGPWPH----EYIHANYVATPT-NPKRFICTQAPLEKTCADFWYMCYQDKVEYI
. |..||. .    | |... |.   .. |||||..   .| || ||   ..    .|| |||.  .  . | .. || || .| |||| | ||..|. |
kdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

FMLCNLLEKGARKCFEYFPSKKGdvMDFEEGGQKISVKCESSVtysfrsdAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENAR
 || .| |.  .|| .||| ...  .. .|  .....| |. |        . . . ...|..   . .|. .|| . ||||. .|    ..|.|... .
vmltklkeaneqkCavyfPdaed..yeiserygdveikvekiv.......erndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleve

P-------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
          .|.||||||||||||  .  .  . || . ...|   || ...| .|   .||. || ..|...  | ..
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Ptp69D_pd Subfamily Ptp69D 54-322 1.8e-50 166.8 In-house 22-289 (307) alignment 
Range on Protein: 54-322
Range on HMM: 22-289/307.0
QGLRAEFVGMRRFnDFEKMKAFKEAQ-EAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.||  |.  . .   ..|   . | .  | ||||.|.   |..||||.   |    .|| |... .  . |.||. |.|.| |  ||| |  . .|. | 
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLCNLLEKGARKCFEYFPSKkgDVMDFEeggqKISVKCESSVTYSFRSDAKANVTATEIViEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--
|| || ||  .||  |.|    | . ..    .| ||. |. . |     . .|. ..    |  |..|| . ||.. |.|  || .  ..|.|.|..  
mlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkee.sgevedsrkvvqyhytgWkDskvPevargllklieqvre

--RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
  . ...||||||||| ||.| .| |. ...|| | . .|  | .  ..|.|||  .|  .|| |... .|.|  . 
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife.tvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 54-329 4.9e-29 95.7 In-house 26-294 (302) alignment 
Range on Protein: 54-329
Range on HMM: 26-294/302.0
QGLRAEFVGMRRF-NDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNPKRFICTQAPLEKTC---ADFWYMCYQDKVEYIF
. ...||  .  .  | || ||||.  .  ||. .|| .||.|.||||.  | .|..|  |  |   .  | .| |  ..    ..|| | .|.|.  ..
aevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLCNLLEKGArKCFEYFPSKKGDVMDFEeggqKISVKCESsVTYSfrSDAKaNVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMA----VLELLE
.|    |       |.|| | ||  ...    |. |     | ..  ...| .  . |.. ||  .    .. |. . |..  ||    .    . .. .
ilvgeeelkk.tlselfpkksgdykeyg....kmfvNnrk.Veka..eeek.tryviEvlPegcsnsvl.anvyvltnWkqkkvpvkyaeliktaakvfa

NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILnYFRKKKLMEETG
.  ... ..|.    |.|| |... |   ...| .|.     | |. .||.|| .....  || ... ..| .. |||. ....
kkikadentvivSknGaGRagafltlavaveklqkgkepnike.ivksiRsqRpravdslkQyvslyiall.lyikkkvtkpee
0046845 (Phosphotyrosine protein) phosphatases II 55-324 7.8e-77 253.7 In-house 1-279 (284) alignment 
Range on Protein: 55-324
Range on HMM: 1-279/284.0
GLRAEFVGMRRFNDFE--KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATP-----TNPKRFICTQAPLEKTCADFWYMCYQD
||..||  ..... .   ......  .   ||||||. ..|..||||  . .    ..||.|.|| ..      ..|.||.||.||..|..||| |... 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVEYIFMLCNLLEKGARKCFEYFPSKkGDVMDFeeggQKISVKCESSVTysfrsDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLEL
.|..| ||..| |.|  ||. |.|.. |.|. .     ...|.. |  .     .    |.  |.. .|.....|. ||.|. .|||.|||.    .||.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef

LENARPS------KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQI--IDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKL
|. .| .      .||||||||||.|||| ...|.....|| ....    | .... ..||||....|| .||.||....|.|...|. 
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPN13_pd Subfamily PTPN13 57-319 1e-48 161.0 In-house 14-269 (273) alignment 
Range on Protein: 57-319
Range on HMM: 14-269/273.0
RAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPheYIHANYVATPTNPKRF--ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNL
  ||  .| .   .. .  |....  ||||..|   |. ||||..  .  || |...  | . ...  | .| || .|..||| | .. |.| | |. . 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

LEKGARKCFEYFPSKKGDVMDFEeggQKISVKCESSVTYSfrsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR---PSK
 |||  ||  |.|..|.. .  .   ... |. .  . ..      . |  .  |..   ...|. .| .. .||| |||.. . .|... . |    ..
kekgkvkchrywPesknkklkvs...nrlevellkvqkld......gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
|||||||||||||.|... .. ... .   . . | ..|. |.||||.  .||. ||.||...||. .
gPivvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreqrqgvvqtkdqyifvykailevl
DSPc_SM00195 59-319 2.7e-77 255.0 In-house 5-262 (263) alignment 
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLL
||  ... .  ....  .. ..  |||||.. . |..||||. .    ...||.|||. .....|..|.||.||..|..||| |... ||..| ||..  
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGARKCFEYFPSKKGDVMDFEeggqKISVKCESSVTYSfrsdakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|.    |||||. .  ...      .... ... ..  | |.|||.|.|....|||.|||   . |||||. .. |    
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ...  .| ..|. ..|.|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 59-319 2.7e-77 255.0 In-house 5-262 (263) alignment 
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLL
||  ... .  ....  .. ..  |||||.. . |..||||. .    ...||.|||. .....|..|.||.||..|..||| |... ||..| ||..  
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGARKCFEYFPSKKGDVMDFEeggqKISVKCESSVTYSfrsdakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|.    |||||. .  ...      .... ... ..  | |.|||.|.|....|||.|||   . |||||. .. |    
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ...  .| ..|. ..|.|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN3_pd Subfamily PTPN3 59-321 2.4e-54 179.2 In-house 20-277 (280) alignment 
Range on Protein: 59-321
Range on HMM: 20-277/280.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPhEYIHANYVATPTNP----KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNL
.|  . | .   ...| . .... ||||.|.   |. ||||.     .|| ||||    .     .|.| || ||.||..|||.| ...|.. | || .|
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

LEKGARKCFEYFPSkKGDVMDFeeGgqKISVKCESSvtysfrsDAKANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK--
.|.|  || .|.|. ..| ...  |  ..|||||..       |.. ..   |.|..    .. || ..  . .||| |||     .||..|. |  .  
verGrvkChqyWPe.tedeley..g..efsvkceke.......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg

--GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
   |.|||||||||||| ...||  .  . | . .    .|. ..|.|| . .|| .|| || . ||. ...
keePvvvhCsaGigrtGvlilletalalieaaepvyp.ldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 59-320 3.3e-24 80.3 In-house 11-260 (267) alignment 
Range on Protein: 59-320
Range on HMM: 11-260/267.0
EFVGMRRFNDFEKM-KAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEK
||  ...  | .     .   . . .||. |.   |..|| |     .||| | || .    . || || ||..| .||. .  . ||  | .| .  . 
efelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd

GARKcfeYFPSKKGDVMDFEEGGQKISVKCEssvtysfrsDAKANVTATEIVIEgpGEKTRKTTHYHWNDWPDRGV------PAADMAVLELLENARPsk
  |.   ..| | |.   ...   . |.. |         .   .. . |. ..   | ... | |... |           |   .   . |||. .  
nirl...fwPPkmgqakkyqdltvehsleke.........endyqiitlelkfk..nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnr..

gPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
 |.||.||.|.||.|. ....  ....   ..  |  . | |||.||   ..|  .|...|... .| .
.PlvvacsdGvGrsGtflvidsqleraktegvs.difdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-322 2e-37 123.5 In-house 22-296 (301) alignment 
Range on Protein: 61-322
Range on HMM: 22-296/301.0
VGMRRFNDFEKMKAFkEAQEAGKNRYKDVGCLDNNRVKLEGPW-----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLL
  ... .| . .  . . ...  ||.|..  .|.||. |.         .||| |.|.   .. |.|| .|.|..|| .||| . .|.|.  | |..|| 
kelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlk

EKGARKCFEYFPSKKGDVMDFEEGGQKISVKCEsSVTYSFRS------DAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----
|.   ||..|.|. . .  .| .   ... ..     .  |.      |.  |      .      .... . ..  |||. ||      ||. .     
egtkskceqywpnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvih

ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
 . ....||.|||||....|.|  . ..  ..|  |  ..|   ..   .| ..   ..|  || ....||  |.. .
rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf.qvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_PTPN12_pd Subfamily PTPN12 63-322 8.5e-57 187.2 In-house 24-280 (290) alignment 
Range on Protein: 63-322
Range on HMM: 24-280/290.0
MRRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHE---YIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGA
... . ... .. .. ..  ||||||.   |..||.|.    .|   || ||..  .......| .|.|| ||  ||| | .. .|| . |.|...| | 
ykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

RKCFEYFPSKKGDVMDFEEggQKISVKCESSVTYSFrsdakanvTATEIVI--EgpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----KGP
 ||  |.|..... . |.|   ..... |  |.  |        .   . .  .   ...|| . .|...|||.|||..   .|||.|..|      . |
kkCerYWpeegeeelefge..fevtleeekavdddf........lirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaP

IVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDG--EKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
.|||||||.|||| .. ..|. ..| |..| ..    ......|.||.  .||  || .|.. ......|.
lvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_egg_pd Subfamily egg 65-341 3.6e-40 132.5 In-house 25-291 (307) alignment 
Range on Protein: 65-341
Range on HMM: 25-291/307.0
RFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKgaRK
   | . ..   .. .  | | | | | |  |||||   | .  ..||||.|        ||..||||  |  ||| | .|..|.|| ||    |    .
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CFEYFPSKKGDVMDFEEGGQKISvkCessVTYSFRSDAKANVTATEIviEGPGEKTRKTTHYHWnDWPDRGVPAADMAVlelLENARPSKGPIVVHCSAG
|  |.|  . | . .  |. .|   .   .    ..|   .||   .   |. .. |   |. . |.   .     . |   |  .|    |.||..  |
ceyywpkaesdslvtvpGslrie..n...lkvdskadplfrvtklkl..vGgddeerflehwqg.dvnnssdvysplrv...lrklrnlskpvvvqdilG

IGRTGSVVMLEYIMDQLLAGQIIDDG-EKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKkLMEETGVQEAYDAFLEQY
. .....| .|  . .|| | |      .  | .| .|. |...  .||||....| .||   .     ..  |. .||..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv.igsakeldvdyerwleer
subfamily_PTPN14_pd Subfamily PTPN14 66-321 5.1e-43 142.2 In-house 35-298 (300) alignment 
Range on Protein: 66-321
Range on HMM: 35-298/300.0
FNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW--PHEYIHANYVATP--TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARK
 .   .... |  ..| |||.|||   ..|||.|       ..|| |  . ..  .. . .| .|.|||.|. ||| | ....|. | || .  |.|  |
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CFEYFPSKKGDVMDFEEGGQKisvkcessVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------------R
.|.|||...      | |  |        ||  |..|... .| .  .   | .. |.  |  ..||||.|||      |. ||.              .
sfkyfPkleskkktvefgkfk........vttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
 || |..||||||.|||| ... . ..  |  .. ||  .|.| ..||||   .|| ||| ||..|...|...
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_PTPRK_pd Subfamily PTPRK 69-317 3.6e-45 149.1 In-house 32-275 (314) alignment 
Range on Protein: 69-317
Range on HMM: 32-275/314.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEY
||   | |. ..  |||..|.   |. ||.|   .|    .|| |... . ..|. || || ||..| .||| . |...   | || .| |.|. || .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

FPSKKGDVMDFEEggqkISVKCESSVTYSFRSDAKANvtateivIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAG
.| .     |..       |..|    .  |  .  .       .. . |..|.  ....  ||| .||    ..|.|. .      ...|.||||||||
WPedtevygdikv....elvetellaelvvrifrvek.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaG

IGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILN
 ||||  .... ..| .   ...|   ..  ..|... | ..|  || |...|||.
aGrtGtfiaidivldmieregvvdv.fnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 69-321 4.6e-42 139.0 In-house 38-281 (315) alignment 
Range on Protein: 69-321
Range on HMM: 38-281/315.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEY
.  ..  |. ..  |||| ..   |. ||.|   |     .|. ||..   . ..|.|..|.|.  .  ||| . .....  | || || |.  ||. .|
lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky

FPSKkgdVMDFeeGGQKISVKCESSV-TYSFRSDakanvtatEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR----PSKGPIVVHCSA
.| |    . .  |   .. | |     |. |.          .|    |.. |.   .|.  ||| |||.  .....|  ...     | |.|||||||
wpdk...kviy..Gkitvtrkseevnteytvrtl........svvf...gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
|.||||. . |. ..||. | ..||   ... ..|..| . .|. .|| |.....|. |  
GvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 70-319 3.9e-36 119.8 In-house 38-288 (325) alignment 
Range on Protein: 70-319
Range on HMM: 38-288/325.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEyIFMLCNLLEKGARKCFEYF
  .|.    ..  |||.|.|  ||..|| ||     |. .|| |.|. .  . . |. .|||| .|  |.| . .. .   . .. | |..|  .|  |.
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrcavyw

PSKKGDVMDFeeGGQKISVKceSSVTYsfrSDAKANVTATEIVIEGpgeKTRKTTHYHWNDWPDRGVPA---ADMAVLELL----ENAR---PSKGPIVV
| . |.   |  || .....  .  ..   ||    |     | .|   .||    ...  |.| ||.    . ...|.|.    |  .    . .||.|
pkemgksktf..Gglevklr..tieei...sdyvhrvldvkqvkkG...etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYF
|||||.||||  . |  ......    .|  .  . |.|..| . ..|  || .... . ...
hcsaGvGrtGvfislysalakvieesrvdifg.fvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 70-237 7.7e-09 29.5 In-house 86-239 (244) alignment 
Range on Protein: 70-237
Range on HMM: 86-239/244.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGarkcfEYFPS
  ||   . ... |||      .| ||| | .|     || | .|        .| || ||  |  ||| |  . .|. . .|  . |.      ||.| 
svmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpd

KKgdVMDF-EEggqKIsvkcesSVTYSFRSDAKaNVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAAD
 .   ... ||    |      .|| . | . | |. |... ||    |  .  | .   .||  |    |
se..plewyee...di......tvtltdrdefk.nikasnleiesdmneshqaltmfqisnwpsdgttpnd
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 71-325 2.8e-56 185.7 In-house 36-277 (288) alignment 
Range on Protein: 71-325
Range on HMM: 36-277/288.0
KMKAFkeAQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKK
 ...|   ... ..||... . |  ||||.   |. ||.|| |..  ...|.||.||||. |   .| |  .  |||| |||.||||| .|  ||||||.
iidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GDVMDFEEGgqkisvkceSSVTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
|. . .             .|.   |.| .  |. . . |. .||..    . |...|.| |||   .. | |||  .  . |||||.|||.|||| ...
Gekarigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlil

LEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLM
   ....|     .   ...| | ||.| ..|||  |||.||...|...  ||  
ilialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvleelllkkyk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 71-322 1.8e-46 153.0 In-house 28-272 (281) alignment 
Range on Protein: 71-322
Range on HMM: 28-272/281.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYF
   .|..  .  |||| .. |||  ||.|.   |     .||||||. .|   . .| || | ..| |||| | .|..   | |||..||    || |||
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PSKKGDVMDFEeggqKISVKCESSVTysfrsdAKANVTaTEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTG
| .   ...|.    |.||. | |         |. || | . .   || ||  ||. |..|||  || .   .|..| . |    | |.|||||.||.|
prnahcclqfd....klsvsyedstv......nkslvt.trlnlsyege.trlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsg

SVVMLEYIMDQLLAGQIIDDGEKILVKIRE-QRNNSIQTDAQYLFVHQVILNYFRKK
... .|  .. . .   . | ..|. ..|   |  |.||  ||... .|.|..    
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 71-321 5.6e-45 148.5 In-house 35-279 (315) alignment 
Range on Protein: 71-321
Range on HMM: 35-279/315.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFP
. .. .| ..  |||||..  ||..|||||       ..|| | |. .  . | .|..|.||. .  ||| | .|.||  | |. .. |    ||  |.|
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

SKKGDVMDFeeGgqKISVKcessvTYSfrSDAKANVTATEIvIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIG
 .|.| ..|  |  .|.|.     . |   .| .. .| .. .   .|..|. | .....|||.||.    ..|.|. . . ..|    ...||||||.|
drkadsvef..G..sikve.....lls..leadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvG

RTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
||| |. .. ...|.  .. .|   ... ..|..|   .||. .| |.....|...  
rtGvvisidevvaqikrtrsvdvf.nfvknlrakrpylvqteeeyafiydavledllw
subfamily_PTPN1_pd Subfamily PTPN1 72-335 6.9e-50 164.4 In-house 24-285 (290) alignment 
Range on Protein: 72-335
Range on HMM: 24-285/290.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG
... |. .. ..|||.||   |  |.|||     .|| |. |  .   ...| || || .|.. || | ...|   . || ...||.  ||..|.|... 
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-DVMDFEEGGQKISV-KCESSVTYSFRSDAKANvtateivieGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS------KGPIVVHCSAGIG
 . . .|.   |. . . |.. .|  |     |            ..||. .|.|.  ||| ||| .  | |..| . | |      .|| |.|||||||
ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGSVVMLEYIMDQLLAGQI--IDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYfrKKKLMEETGVQEAYD
|.|...... .. .. . .     | .| |...|..|   |||  |  | .. ||.    |...... ||. . 
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG..akvikgdssvqkrwk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 72-321 7.4e-37 121.7 In-house 30-279 (287) alignment 
Range on Protein: 72-321
Range on HMM: 30-279/287.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKL--EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSK
.|| .|  .. |||| ||  .|..|| |  ||    .|| |||||. |. ..||..|.|.  |  ||| . .. ..  . ..   .|..  ||..|.| .
fkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

kGDVMDFeeGGQKISVkcessVTYSFRSDAkaNVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA--D--MAVLEL---LENARPS--KGPIVVHCSA
    |    ||  . .     . |. ..      . .  .|.  ....|    ... .|||.... .       ||.    .| || .   ||.|||...
.evPmrv..GGysvvl.....ldydikePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

GIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
||||.| .. .  ....|.    .|   ......||.|.  .|.  |. .. . .  |.. 
GiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_PTPRA_pd Subfamily PTPRA 73-320 9.5e-48 157.7 In-house 51-296 (330) alignment 
Range on Protein: 73-320
Range on HMM: 51-296/330.0
KAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSK
.. .. ..  |||. ..   | .|| |   ||    .|| | ..    . ..|| .| |.|.|  ||| | .. |   | || .| |.   ||  |.|..
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

kGDVmdfEEGGQKISVK-CESSVTYSFRsdaKANVTatEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP----SKGPIVVHCSAGIGR
 | |     |  ...|. .. .| |. |   |  |.  ..  .   .|.|  . .|.. ||| |||.  . .|.||.. .     | ||||||||||.||
.Glv...tyGnirvevedetvlvdytvr...kflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

TGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYFR
||. ..|. ..... | ...|  | .. ..| || . .||| || |...|.|.|. 
tGtfivldavlervkaerkvdvfe.fvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 74-330 4.6e-50 164.9 In-house 48-301 (310) alignment 
Range on Protein: 74-330
Range on HMM: 48-301/310.0
AFKeaQEAGKNRYKDVGCLDNNRVKLEG--PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkG
|.|  ..  |||| || |||. ||||.      ..||||||| |    . |||.| ||..|  ||| | .|.. | |..||.  |.|  ||  |.||  |
ayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.g

dVMDfEEGGQKISVKCESSVTYSFRSDAKANVTATEIVIEGPGE-KTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
 | .   |  ...  .|||  .     | . |     | | | . |  . .  .| .|||||||      .     |.  .|| |||||||..|.. || 
.vte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvva

LEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETGV
|.. .|.|  |. .|  |..  ... .|   |||. |||....| . . | .. . |. .
lklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifargetevaekil
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 74-318 9e-35 114.8 In-house 39-235 (392) alignment 
Range on Protein: 74-318
Range on HMM: 39-235/392.0
AFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGarkcfeyfpskk
. ..  .  |||||..  .|..|||||       ..|. | |. .  | | .|..|.|   .  ||| | .|..|  | |. .| |              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

gdvmdfeeggqkisvkcessvtysfrsdakanvtateiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTG
                                           |...|  . .|. .|||..||    ..|..... .   |    |...|||||.||||
..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtg

SVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNY
 |. .. .. .    ...|   .....||..|   .||. || |..  .|. 
vvisidsvvahakktrmvdv.fnfvtnirrkrpymvqtkeqyafiygavled
0037934 (Phosphotyrosine protein) phosphatases II 75-319 1.7e-60 199.9 In-house 5-242 (243) alignment 
Range on Protein: 75-319
Range on HMM: 5-242/243.0
FKEAQEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPtnpKRFICTQAPLEKTCAD----FWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPskk
..  .   ||||.|. ..|..||||||   . ||.||..  .   .|.|.||.||..|..|    || |... ....| ||..| |.|. ||..|.|   
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

GDVmDFEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG--PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR------------PSKGPIVV
|.|  ...    ..|.. |. .       ....| .....|   ... ||  .|||.  ||| |||     .|..|. .|            .|.||..|
gev.tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV

HCSAGIGRTGSVVMLEYIMDQLlaGqiiDDGEKILVKIREQRNN-SIQTDAQYLFVHQVILNYF
|||||.|||| .... .....|  |    | |... ..||||.. ..||  || |.....| ..
HCsaGvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 76-321 3.4e-49 162.3 In-house 16-266 (270) alignment 
Range on Protein: 76-321
Range on HMM: 16-266/270.0
KEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVA-TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG
. |...  |||.|.    . ||.||        .|| ||||.    ..|..|....||. |  .|| | .. ||. | |. .| ||| .||  |.|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DVMDFEEGgqKISVkcessvtYSFRSDAKANVTATEIVIEGPGEKTRKTtHYHWNDWPDRGVPAADM------AVLELLENAR-----PSKG-PIVVHCS
. ...|.|  ||.|        .  .  .    .|.. .|  ||. | . |...|.|||.||| ..        .|..|.. |      .|. |..||||
ekvkledg..kikv.......lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
||.|||| ...|....  |   . . |  .|. ..|..| . .|.  || |.......| ..
aGvgRtGtlialDiavrlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 76-319 7.8e-48 157.8 In-house 5-242 (250) alignment 
Range on Protein: 76-319
Range on HMM: 5-242/250.0
KEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARkCFEYFPSKKGD
|. |.  |||| |.  ||. || ||        .|| | .. . .. | || ||.||..|  ||| | ...|.. | || || |..   . .|.| .| .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

VMdfeegGqKISVKCESsvtysfrSDAKANVTATEIVIEGPGEKT-RKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTG
       | .. |.  |       .. .|..| .....    ..  |   ..|.  |||.|||.   ||||||.. .       ..|..|.||||.||.|
ky.....G.dvtvslls.......keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

SVVMLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYF
. . .. ....|   ...|   |.. ..|..| ..... .|| ||...||.. 
afiaidavlerlkkekvvdv.fkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 76-316 6.9e-34 112.1 In-house 4-238 (239) alignment 
Range on Protein: 76-316
Range on HMM: 4-238/239.0
KEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKG
|.  .  |||| ..   | .|| ||     || .|| |.|.     .|| .|.||  .| .. ||| | .|..   | ||  |.|   .||..|.|    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

DVMDFEEGGQkisvKCESSVTYSFRSDAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGS
   ..    .    | |    |  |.   ..|  ||          |   .||.  |||.|||    ||| |     ... |   | |.|||||.||||.
kycnlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVIL
..... .. |    . .|  .  .  |||.|   .||  ||.|.|  .|
flvidamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavl
subfamily_CG7180_pd Subfamily CG7180 76-319 3.5e-29 96.4 In-house 38-290 (296) alignment 
Range on Protein: 76-319
Range on HMM: 38-290/296.0
KEAQEAGKNRYKDVGCLDNNRVK---LEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGArKCFEYFPSKKgd
 ...  .|||. .|   |.|||    |.|    .|| | || . . .| .| |.|| ..|  .|| . |..... . .|..  .    .. .|.| |   
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..

VMDFEEggqkISVKCESSVTYSFRSDAKANVT----ATEIVIEGPGEKTRKTTHYHWNDWPD-RGVPAADMAVLELLE-------NA--RPSKGPIVVHC
  .. |    | |.  .. .|.     .  .|    |.    ..   .||  .....  |.    ||    |..||..       ..  .| .||.||..
keqyge....ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILNYF
| | .|.|  . ..  ....   . .|  |  . ..|..|.. ...  .| .. .|.|...
sdGasRsGvylaidanlelvekeeevdvFe.avktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 77-322 1.5e-28 94.5 In-house 44-347 (350) alignment 
Range on Protein: 77-322
Range on HMM: 44-347/350.0
EAQEAGKNRYKDVGCLDNNRVKLE-----------GPWPHEYIHANYVATP-----TNPK-RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGA
  .   |||||..   . .||||.              . .|| |||.  .      ||. ..| ||||| .|  ||. .....||. | .| .. | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

RKCFEYFPSKKGDV-------MDFEEGGQKISVKCESSVTYSFR------SDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE-
.|| .|..  . |        .  . .| . |..  . |   .        | . .   . . |.          . ... |.| ..      .|. || 
ekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalev

--------NAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQL--------------LAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNY
        .|.         ||.||||||.|||| .| |.... ..               | .. |  . |. ..|.|| . .|.  |..|... .|.|
kndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy

FRKK
|. .
faLr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 77-235 3.3e-28 93.4 In-house 27-181 (297) alignment 
Range on Protein: 77-235
Range on HMM: 27-181/297.0
EAQE---AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVATPTNPK--RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKK
 |.      ||||.|.   |..|||| .  . ..|| |.||. | ...  ..|..| ||..|  ||| . ... |  | |...| | |  ||. |.|| .
sakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

GDVMDfeeGGqkiSVKCESSvtySFRSDAKANVTATEIVIEGPgEKTRKTTHYHWNDWPDRGVPA
.. .     |   .|  |     |  ||   .|  ||. .    ...|. .|  .  ||| |||.
qerlk...ag...dvvvefl...sstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvps
0045098 (Phosphotyrosine protein) phosphatases II 78-322 6.1e-65 214.7 In-house 31-275 (278) alignment 
Range on Protein: 78-322
Range on HMM: 31-275/278.0
AQEAGKNRYKDVGCLDNNRVKlegpwphEYIHANYVATPtnPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDFe
   . ||||||. ..|..|||       .||.|.|. ..  ||.||.||.||..|.|||| |... ....| ||..|.|.|  ||..|.|.  |... . 
lgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggslty.

eggQKISVKCESSVTYsfRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--MAVLELLENARP-----------------SKGPIVVHC
    ...|...|  ..      .   . | . .| .. ..|. ||.|.  ||| |||  .  . .|||||  |                  |.||..|||
...gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGSVVMLEYIMDQLlaGQIIDdGEKILVKIREQRNN-SIQTDAQYLFVHQVILNYFRKK
|||.|||| .|.. .....|  .. .|  .... ..|.||.. ..|.  || |.....| .....
saGvgRtGtlvaaylmlell..eggvd.lleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 78-320 1.7e-44 146.8 In-house 41-277 (515) alignment 
Range on Protein: 78-320
Range on HMM: 41-277/515.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVM
  .  |||||..  .|..|||||       ..|. | |. .  | | .|..|.|.. .  ||| . .|..|  | |. .| |    || .|.| | || .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

DFeeGgqKISVKcessvTYSFRSDAKAnVTATEIVIEgpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTGSVVM
 |  |  .|.|.     . |  ... . .  .  |.   |...|  | .|...|||.|||    ..| |. . . ..|    |...|||||.|||| |. 
kf..G..sikve.....lvsleactgg.ikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

LEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
.. .. .   ....|   ... .||..|   .||. || |.....|... 
idsvvahakttrmvdvf.nfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 78-317 2.3e-40 133.9 In-house 59-289 (319) alignment 
Range on Protein: 78-317
Range on HMM: 59-289/319.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnllekgARKCFEYFPSKKgdvm
 |.  |||. ..   |.|.||||   |    .|| | .|.   .....| .| ||. | |||| | .. ..  | .|         || .|.| |     
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki....

DFEEGGQKISVKcesSVTYSFRsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSV
. .|.  |..|.   ||. .        |   |.  .|  .  || | .|.  ||| |||   . .. |...          . .||||||||.||||  
vikeerfkvkvd...sveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

VMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILN
..|. ..|..   . .|   ...  .|.|||. .|  .|| |..  .|.
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 78-317 1.4e-39 130.7 In-house 31-264 (283) alignment 
Range on Protein: 78-317
Range on HMM: 31-264/283.0
AQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVA---TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkGdVM
 ..  |||....   |..||.|. . ...|| | ..       . |..| .|.||..|  ||| | ...|.  | || .| |    ||  |.|.. |  .
denkrknrnqeivpadqwrvelk.sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.G.se

DFeeGGQKISVKCESSVtYSFRSD-AKANVTateivieGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELL-ENA-RPSKGPIVVHCSAGIGRTGSVV
|.  |   .... | .   ||       .|        .  ..|   .||  .|| . |  |    .  ....  .  .  |||||||||.|||||.  .
dy..Geftvtlrketts.nsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

MLEYIMDQLLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILN
 .   ....|.  ..|   ...  .||||   .||  || .||...|.
aasasvkdaltesvvdv.favvkimreqrmmavqtldqyklvhelvle
0042113 (Phosphotyrosine protein) phosphatases II 79-320 4.1e-64 211.6 In-house 8-244 (245) alignment 
Range on Protein: 79-320
Range on HMM: 8-244/245.0
QEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMD
    ||||.|. ..|..||||  . .   . ||.|.|| ..  ...||.||.||..|..||| |... ....|.||... |.|  ||..|.|.  |... 
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt

FEEggqkISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
...    ..|.. |  .       ....| ... ..  .  ..|. .|||. .||| |||  .  .|..|| .|      |.||..||||||.|||| ..
ygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

MLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
.. ....|| . . ..  |... ..|.|| ...||. || |.....|....
aaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 79-317 6e-40 132.5 In-house 24-253 (284) alignment 
Range on Protein: 79-317
Range on HMM: 24-253/284.0
QEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnllekgARKCFEYFPSKKgdvmD
|.  |||. ..   |.|.||||   |    .|| | ...   .....| || ||. | |||| | .. ..  | .|         || .|.| |     .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki....v

FEEGGQKISVKcesSVTYSFRsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSVV
 .|.  |..|.   ||. |        |   |.  .|  .. || . .|.  ||| |||   . .. |...          . .||||||||.||||  .
ikeerfkvkvd...sveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

MLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILN
.|. ..|..   . .|   ... ..|.|||. .|  .|| |..  .|.
vldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 79-317 7.3e-34 112.0 In-house 6-238 (239) alignment 
Range on Protein: 79-317
Range on HMM: 6-238/239.0
QEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVM
 .  |||| ..   | .|| ||     || .|| |.|.     .|| .|.||  .| .. ||| | .|..   | ||  |.|   .||..|.|       
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

DFEEGGQkisvKCESSVTYSFRSDAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGSVVM
..    .    | |    |  |.   ..|  ||          |   .||.  |||.|||    ||| |     ... |   | |.|||||.||||....
nlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv

LEYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVILN
.. .. |    . .|  .  .  |||.|   .||  ||.|.|  .|.
idamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavle
subfamily_ptpA1_pd Subfamily ptpA1 79-277 7.8e-27 89.0 In-house 46-255 (418) alignment 
Range on Protein: 79-277
Range on HMM: 46-255/418.0
QEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATpTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVmD
... |||| ..  ..  ||.|.        .|| |||.   . ||.||||| || .| |||| | .....  | ||    |.   ||  |.| . |   .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.q

FEEGGQKISVKCESSVT-YSFRSDAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------RPS---KGPIVVHCSAGIGR
|   |.   |    ||       | . .. . .| .   || ||  |.|... |||. .|     . .|| .         ||   . ||.||||||.||
fsiygngnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGSVVMLEYIMDQ
||...    .| .
tgtfctavimmkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 79-318 4.8e-21 69.7 In-house 46-278 (303) alignment 
Range on Protein: 79-318
Range on HMM: 46-278/303.0
QEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPTNpKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPsKKGDVMDFEE
..  |||. || |||  .|||       ||||.|.   .. |. | || || .|.|||| |  ..||  ...|    |         || .. | ..|||
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfee

ggQKISVKCESSVTYsfrsdakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--------MAVLELLENARPSKgPIVVHCSAGIGRTGSVVM
  . | |     |         ..  .  ..    |.       .|...||   .|.            .  .| .  .|. | |    .| ||.|.  .
..rsirvgefkrvel.......gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

LEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNY
.|     | . |   |  | | ..|. |  ..|  .|. .|. .. ..
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
0040439 (Phosphotyrosine protein) phosphatases II 80-321 6.8e-67 221.0 In-house 11-248 (249) alignment 
Range on Protein: 80-321
Range on HMM: 11-248/249.0
EAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkGDVMDF
   ||||.|. ..|..||||   .| ... ||.|.|. ..  ..|||.||.||..|..||| |... ....| ||..| |.|  ||..|.|.  |... .
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley

eeggQKISVKCESSVTysfrsdaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVV
     ...|.. |  .       |...| ... ..     ..|. .|... |||| |||     .|...| .|       ..||..||||||.|||| ..
....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

MLEYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.. ....||   . .|  | .. ..|.||....|.. || |.....| ...|
aaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 80-317 7e-40 131.8 In-house 48-277 (439) alignment 
Range on Protein: 80-317
Range on HMM: 48-277/439.0
EAGKNRYKDVGCLDNNRVKL-EGP-WPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEkgarkCFEYFPSKKgDVMDf
.  |||||||| .|  || | | |  ||  || |||.    ..| .| ||.| ..|. ||| . .. |.  | ||.||.|      . |.||.. .|.  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywpsda.evcy.

eeGgqKISVKCESSVTYSFRSDAKANVTATeiviEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----ENARPSKGPIVVHCSAGIGRTGSVVML
  |   |.|...  .          .|          .|| |   ..|.  |||. |||    ||..|      | .   ||.|||||||.||||... |
..g..diavrvdrnielpnyvirgfkvfne....rdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiial

EYIMDQLLAGQIIDdGEKILVKIREQRNNSIQTDAQYLFVHQVILN
.  ..|| . . .|  . |.  .|.||.. .|. .||.|... .|.
dialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 80-321 1.5e-36 121.0 In-house 51-286 (297) alignment 
Range on Protein: 80-321
Range on HMM: 51-286/297.0
EAGKNRYKDVGCLDNNRVKLEGPWPH---EYIHANYVatPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLlEKGARKCFEYFPSKKgdVMDF
.  |.|||..   | .||||.    .   .|. | .|  ..| .|.|.|| | . | |||| | ....|  | || .. ... .||  |.. |   |. |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkg..vttf

eegGqKISVKCESSvtysfrSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
   | ..||. .|       |. .  .  .  | .|   ..|    |.. .|||. |.      ..|.|... |      ..||..|||.||.|||| ..
...G.dvsvvllsv......sereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

MLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
 .. .. .    . .|   ... |.|..| . .||. || ||....|...  
tidsvvaeakrekevdif.glvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 80-153 3.1e-07 24.2 In-house 37-118 (347) alignment 
Range on Protein: 80-153
Range on HMM: 37-118/347.0
EAGKNRYKDVGCLDNNRVKLEgP---------WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCN
.  ||| |||   |. || |  |          .. || | ..      | .| || || .|  ||| | .  ||  .  . .
slsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 81-312 9.5e-51 167.3 In-house 51-274 (301) alignment 
Range on Protein: 81-312
Range on HMM: 51-274/301.0
AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEgg
  |.||. | |  .  |..        ||||.. |. .|.|||.||.||..|. ||| |. | .|| | ||.. .||  .|| ||.|.| .. .| .   
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr..

QKISVKCESSVTYSFRSDAKANVTATEIVIegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA
 || .| . ..     |  . .|. .   .     .||  ||| ...|.||||| . . . .|.| .. |. ||||||||||||. . .  ||.  ...|
fkikiknkelilnkkiskrtlevedstgkf.....atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea

GQIIDDGEkILVKIREQRNNSIQTDAQYLFVH
 . |.  |  | ..||.| |..||  |  .. 
dptielte.alkhlrehrwngvqtnsqlywmt
subfamily_PTPN23_pd Subfamily PTPN23 81-321 5.8e-50 164.7 In-house 44-282 (288) alignment 
Range on Protein: 81-321
Range on HMM: 44-282/288.0
AGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVA--TPTNPKrFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEE
. |||..|.   |.|||||.|    .|| | .|   .|. |. ||.|||||..| .||| | |..|.. | || .  |.|  |. .|.|..||. . |..
seknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd

ggqkISVKCESSVTYSFRSDAKANVTATeiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--------RPSKGPIVVHCSAGIGRTGSVVM
    .|| ..|  . .  .. . ...        . ..... .| ... ||. ||||.   .|..|...        |.|| |.|||||||.|||| . .
....lsvtlksvretethvervlkletl......dadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal

LEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRK
.  .. .| .|... |  ... ..|||| ...|. .|. |. ...|.. |.
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 81-316 8.5e-41 134.7 In-house 4-236 (237) alignment 
Range on Protein: 81-316
Range on HMM: 4-236/237.0
AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVmdfEE
  |||| .. . | .|| |.|.    .|| |.|.      ||..|..| ||| .| ||| | .|.|   | ||  |.|.   || .|.|| .        
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ay

GGQKISVK-CESSVTYSFRSDAKANVTATEiviegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----AR--PSKGPIVVHCSAGIGRTGSVVML
|   .|.|  |    |. ||   .. .  .        . |    |..  |||||||    |.| .  |    ..  .  || ..|||||.|||| ....
gvltvslkkkeefsdytvrslllskrltlk........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

EYIMDQLLAGQIIDDGEkILVKIREQRNNSIQTDAQYLFVHQVIL
. .. |    ...|  .  .  | |.|   |||  ||.|.||.||
damlrqakekkvvdiyn.yvysieedrpyiiqtkdqyvfihqtil
0049772 (Phosphotyrosine protein) phosphatases II 81-323 6.4e-36 120.0 In-house 47-284 (314) alignment 
Range on Protein: 81-323
Range on HMM: 47-284/314.0
AGKNRYKDVGCLDnNRVKLeGP---WPHEYIHANYVATPtnpKRFICTQAPLEKTCADF----------WYMC--YQDKVEYIFM---------------
  ||||.|. . | |||.| .      . ||.|.|| ..   ..||.||.||| |. ||          | |   .. .| .| |               
rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCNLLEKGARKCFEYFPSKKgdvmdfeeggqkisvkcessvtysfrsdakanvtateI-------ViegpgekTRKTTHYHWNDWPDRGVPAAD
      |..| ..|.  ......  |                                             .       .|   .|.. ..|| ..|  .
AlgKtpllildgngneptaadlellk.....................................eelydpelf.......erlgikylripvpDgsaplle

M--AVLELLENArPSKGPIVVHCSAGIGRTGS-VVMLeYIMDQLlagQIidDGEKILVKIREQRN-----NSIQTDAQYLFVHQVILNYFRKKK
.  ..||..|.| . .||..|||.||.||||. ||.  |.| .|   ..  . |..|  .|..|      ..|..  ||.|.....|.|....|
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa.ylmkll...gv..sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
Y_phosphatase Protein-tyrosine phosphatase 82-317 2.6e-72 238.4 Pfam-A 3-235 (235) alignment 
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEgg
 ||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..| ||| .|| .|.|..... . ...  
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..

qkISVKCEssvTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
  |.|...   . . . ... ... .|.  ..  ...|.....|...|||.|||.   ..|.|... . ||    ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILN
|| |..   |  .|. ..|.||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 82-317 2.6e-72 238.4 In-house 3-235 (235) alignment 
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEgg
 ||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..| ||| .|| .|.|..... . ...  
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..

qkISVKCEssvTYSFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
  |.|...   . . . ... ... .|.  ..  ...|.....|...|||.|||.   ..|.|... . ||    ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QLLAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILN
|| |..   |  .|. ..|.||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 82-323 3.8e-45 149.1 In-house 3-175 (182) alignment 
Range on Protein: 82-323
Range on HMM: 3-175/182.0
GKNRYKDVGCLDNNRvklegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnllekgarkCFEYFPskkgdvmdfeeggq
 ||||.|. . |..|       .  ||.||... .  ..|||.||.|| .|.|||. | .. .. .| .|.         .. |.|              
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............

kisvK-CessvtysfrsdakanvtateiviegpgekTRKTTHYHWNDWPDRGVPAaDMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQlla
    . .                             .|  ..|..  ||| |||     .|...| .. ..||..||||||.||||..|.. ... .   
....ell.............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...

gQiiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
 .   . |...  .|..|.....|  || |.....| ... ||
.g..vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 82-331 3.6e-42 139.3 In-house 37-282 (285) alignment 
Range on Protein: 82-331
Range on HMM: 37-282/285.0
GKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNP-KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGG
  ||| || |... || |.    ..||||...  | .    .| || || .| .|||.| ||.|. |..||| |.| |  ||  |.| | |.|. | .  
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye

QKISVKCESSVTYSFRsDAkANVTATEIVIEGPgektRKTTHYHWNDWPDRGVPAADMAVLELL---ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQ
  ..   | ... .   .|   |. ||     |        | .   |||.  |     ..||    ..  | . ||.||||||.||| ..| ..|   .
itlteckeeaiagtil.na.ltvintedassep....lymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatir

LLAGQIIDDgEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETGVQ
..    |.    |. ..|  | ...|.  |.||.. |...||  . ..| ||  
imenpniem.ldivremramrfqavqshmqflflyvvlmeyfigegvvertgqi
subfamily_eak_pd Subfamily eak 83-235 4.3e-10 33.5 In-house 55-196 (332) alignment 
Range on Protein: 83-235
Range on HMM: 55-196/332.0
KNRYKDVgCLDNNRVKLEGP--WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFeeGg
.| .| |   | . |.|      .  || |  .  .   ...| | .. |.    || | .. |   | .| . .|..  |   ||| |  ....|  | 
rnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf..G.

qKISVKCESSVtysfrsdaKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA
 .. |.. . |        | |.  |  ..   |..| .  ||.   | .  .| 
.ildverkefv........krniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 89-333 7.4e-34 112.2 In-house 27-262 (290) alignment 
Range on Protein: 89-333
Range on HMM: 27-262/290.0
VGCLDNNRVKLEG---PWPHEYIHANYVATPTNpKRFICTQAPLEKT-------CADFWYMCYQDKVEYIFMLCNLLEKGAR----KCFEYFPSKKGDVM
|  . ..|| |.|       .|||||.|  | .  |.| ||.|.||.         .||.|  |.||. . |||.  || |      | .|.| . |. .
vpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

DFEEggqkISVKCessvtysFRSDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyI
 |.     ..|||           .. .|   |.|..  .|.  . ||.  ..| .. |.     .|.|... . || |..|||  || |   .  .. .
kfkg....ltvkC.......kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.l

MDQLLAGQ-IIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILnyfrkkklmeeTGVQEA
  |..|..      |..| ..|.||.. |... .. ||  .|.             ..|.
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...........llaiev
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 93-213 2.8e-07 22.4 In-house 58-178 (327) alignment 
Range on Protein: 93-213
Range on HMM: 58-178/327.0
DNNRVkLEGPwPHEYIHANYVATptNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNL---LEKGARKCFEYFPSKKGDVMDFEEGGQKISVKCES
|| || | |    |..  .||    .   .|  ||| .|.    | .  .|..  .  ||           ||. |||..  . |. |     .|. |..
dnrrv.lcgs.deeffpgqyvrm..egaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsivcka

SVTYSFRS-DAKANVTATEIVIEGP
    |. .   . ..| .|.||.  
reglsmgatkyeleltdsevvidkn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 95-232 7.3e-07 23.6 In-house 8-125 (130) alignment 
Range on Protein: 95-232
Range on HMM: 8-125/130.0
NRVKlegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGarkcfEYFPSKkgDVMDFEEggQKISVkcessvTYS
.|..      ..||.|..|    . . .. ||.|| .|. ||| |  .  |. . .|  . |.      ||.|    . ... |  ..| |      | .
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds..ePlewye..ediiv......tlt

FRsDAKANVTATEIVIEGPGEK-TRKTTHYHWNDWPDRG
 | |   |. |... ||    .  .  | ..  .||  |
dr.defknikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 98-322 4.6e-31 103.2 In-house 11-174 (178) alignment 
Range on Protein: 98-322
Range on HMM: 11-174/178.0
KLEGPWPHEYIHANYVAtptnPKRFICTQAPlektcADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGdvmdfeeggqkisvkcessvtysfrs
.|||..  .||.|...     |  ..... |     ||.. . .. .. .| .|.. || |  ||..|.|.. |                          
nleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

dakanvtateiviegpgektrktTHYHWNDWPDRGVPA---ADMAVLELLENAR-PSKGPIVVHCSAGIGRTGSVVMLEYIMDQllagQIidDGEKILVK
                        .|..  .|| |||      ....|..|.|. ...||..||||||.||.|..|.. ... .    ..  . |...  
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl..sleeaiel

IREQRNnSIQTDAQYLFVHQVILNYFRKK
.||.|.  .... |. ..... | .. ..
vrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 99-167 1.4e-11 38.3 In-house 84-154 (349) alignment 
Range on Protein: 99-167
Range on HMM: 84-154/349.0
LEGPWPHEYIHANYVATPT--NPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFP
 ..  ...|| |||.  .     |..|.|||||  |  ||. .   ..|. .. | .  |.. .||  |. 
sdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
0046846 (Phosphotyrosine protein) phosphatases II 101-320 1.2e-39 131.2 In-house 8-174 (176) alignment 
Range on Protein: 101-320
Range on HMM: 8-174/176.0
GPWPHEYIHANYVATPtnpkRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMdfeeggqkisvkcessvtysfrsdak
 ...  ||.||.....    |.|.||.||..|.|||. | .. .......|... |.|  ||. |.|  ..  .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

anvtateiviegpgektrkttHYHWNDWPDRGVPAAD--MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyimdqLLAGQIIDDGEKILVKIREQR
                     .|.. .||| |||  .  . .||....|. ..||..||||||||||| .|..      ||  .   . |..| ..||||
.....................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqR

N-NSIQTDAQYLFVHQVILNYFR
  ...||..|| |.....| ...
plgavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 105-313 2.1e-38 127.1 In-house 5-155 (172) alignment 
Range on Protein: 105-313
Range on HMM: 5-155/172.0
HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLlekgarkcfeyfpskkgdvmdfeeggqkisvkcessvtysfrsdakanvt
. ||.|.|. ..  |.|||.||.||  |.|||| |... .. .|..|..|                                                  
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

ateivIEGPGEKTRKTTHYHWNDWPDRGVPaADMAVLELLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllaG-QiidDGEKILVKIREQR
        |   .|   .|..  ||| |||     .||.||      |. ..||..||||||.|||| .|.. ...           . |...  .||.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl...sleeavalvrekR

NNSIQTDAQYLFVHQ
....|.. || |...
pgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 105-313 1.4e-37 124.4 In-house 2-164 (174) alignment 
Range on Protein: 105-313
Range on HMM: 2-164/174.0
HEYIHANYVATPTNPKRFICTQAPLEktcadFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSkkgdvmdfeeggqkisvkcessvtysfrsdakanvt
. ||.|...     ..|.|..|.||.     ||.|... ......||... |.|  ||. |.|.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

ateivieGPGEKTRKTTHYHWNDWPDRGVPAADMaVLELLENARPS-----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLagQIIDDGEKILVKIREQRN
        .   .|   .|..  |||.|||  .. .||... ..       .||..||||||.|||| .|.. ... .||  .  .|  ... ..| || 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp

NSIQTDAQYLFVHQ
...||. || |...
gmvqtpsQyrflyy
subfamily_CG42327_pd Subfamily CG42327 105-250 1.6e-22 74.6 In-house 56-193 (319) alignment 
Range on Protein: 105-250
Range on HMM: 56-193/319.0
HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKkgdvmdfeEGGQKISVKCESSVTYSFRSDAKANV
 ||..|.||  . . |  .|..|..||.. .||| . .. .   |  |..| |.| ..| ||.|.|        |...  |.  .  ||   |   .  .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk........etldntslyGdilvtlkgrevkdrya

TATEIVIEGPGEKTRKTTHYHWnDWPDRGVPAADMAVLELLENARPS
..| .. .  .|..|. ||| . .|.. .||| . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0051429 (Phosphotyrosine protein) phosphatases II 106-342 4.4e-49 162.8 In-house 5-248 (272) alignment 
Range on Protein: 106-342
Range on HMM: 5-248/272.0
EYIHANYVATPTN---PKRFICTQAPLEKTCADFWYMcYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQKIS-VKCESSVTYSFRSDAKA
 ||.|..| ....   |.|......||. |.||||.. .. .. .|..|... |.|. ||. | |  .  ...... .     . . .  ..|.      
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

NVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADmaVLELLENARPsKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDD-------GEKILVKI
 ..  ..... . ...|. .|.|. ||||.|||     .|||||  .  .||..||||||..||| ||.| ... .. . .|.||        |... ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

REQRNNSIQTDAQYLFVHQVILNYFRKKKLMEETGVQEAYDAFLEQYK
|.|| ...||..||||.....|...|.   ...  .. |.||. |.| 
raqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyG
0051082 (Phosphotyrosine protein) phosphatases II 106-315 1.4e-29 98.0 In-house 4-149 (151) alignment 
Range on Protein: 106-315
Range on HMM: 4-149/151.0
EYIHANYVATPtnpkrFICTQAPLEktcaDFWYMCYQDKVEYIFMLCNLLEKGarKCFEYFPSKKgdvmdfeeggqkisvkcessvtysfrsdakanvta
 ||...||        ......||.    ||. . .. .. .|..|... | |  .| ||.|.                                     
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

teiviegpgektRKTTHYHWNDWPDRGVPAADMAVLELLENARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQllagqiiDDGEKILVKIREQRNNSIQT
            .. .|... |||| |.|    ||||.|| ..   .||..||||||.|||| .|.|  .. .        . |..|  .|..| ...|.
............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp

DAQYLFVHQVI
  |.||.....
nqqflfqlfal
0049260 (Phosphotyrosine protein) phosphatases II 117-313 2e-33 110.6 In-house 6-144 (152) alignment 
Range on Protein: 117-313
Range on HMM: 6-144/152.0
TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFpskkgdvmdfeeggqkisvkcessvtysfrsdakanvtateiviegpgek
 .|..||.||.|.. |.|||| | .. .. .| ||..|||.|  || .|.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

trkttHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllagqIIDDGEKILVKIREQRNNSIQTDAQYLFVH
     .|..  ||| |||  .. .|.||.     |. ..||..||||||.|||| .|.. ...          . |...  .||.|......  |. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

Q
.
e
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 120-313 1.2e-11 39.1 In-house 4-197 (198) alignment 
Range on Protein: 120-313
Range on HMM: 4-197/198.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLE-KGARKCFeYFPSKKGDVMDFeeGgqKISVKCEssvTYSFRSDAKA-NVTATEIVIEgPgEKT
.|.|.|| || .| |||| | ..    .| |. .    | |   | |.|. .  .  .  |   .|| ..   | . ..|     .  |. .   |   |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..g..slsvttk...tittkpdytitaliltnntta.p.pst

RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL-LAGQIIDDGEKILVKIREQRNNSIQTDAQYL
|. .|| .  | ..  |   . |  ..     |         |..|||| | | ||  | |.  .     .   . |  ..  ..|. |   | .  .| 
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

FVHQ
|..|
fiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 120-313 1.3e-11 39.0 In-house 5-198 (199) alignment 
Range on Protein: 120-313
Range on HMM: 5-198/199.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNLLE-KGARKCFeYFPSKKGDVMDFeeGgqKISVKCEssvTYSFRSDAKA-NVTATEIVIEgPgEKT
.|.|.|| || .| |||| | ..    .| |. .    | |   | |.|. .  .  .  |   .|| ..   | . ..|     .  |. .   |   |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..g..slsvttk...tittkpdytitaliltnntta.p.pst

RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL-LAGQIIDDGEKILVKIREQRNNSIQTDAQYL
|. .|| .  | ..  |   . |  ..     |         |..|||| | | ||  | |.  .     .   . |  ..  ..|. |   | .  .| 
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

FVHQ
|..|
fiyq
subfamily_hpo-7_pd Subfamily hpo-7 125-332 3.1e-21 70.5 In-house 39-242 (263) alignment 
Range on Protein: 125-332
Range on HMM: 39-242/263.0
TQAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEggqkISVKCESSVTysfrsdakANVTATEIVIE--GPGEKTRKTTH
... | .| . |. .  | | | . |||.  |.|  || .||| .| . . ...    ..| .  ..           .  |. ...  |   ||.. .|
lysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan....vnvcttkvqs........dvllktlellstlgeKkkthtvkh

YHWNDWPDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLL----AGQIID-DGEKILVKIREQRNNSIQTDAQYLFVHQVILN
| .. |...  |     .|..|. || || ..|||||.||||. . .. | .  ...      . .. |  ..| ..|..|. .|.|  |  |   ..|.
ysykgWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

YFRKKKLMEETG--VQE
.. .    .|     ||
fvlnnfakgeleakyqe
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 126-331 1.3e-26 87.8 In-house 97-295 (302) alignment 
Range on Protein: 126-331
Range on HMM: 97-295/302.0
QAPLEKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEGGQK-ISVKCEssVtYSFRSDAKANVTATEIVIEGPGEKTRKTTH-Y
  |  .|.  .| .  | .|  .  ||.. |.. .|| ||.  | |... | .   | .||| .  .   |    .... . ||  |   .|..|| .  
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd..l.eeftdkksfklytveiknekkkkkvkktvdil

HWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVIlnyfrKKK
..  ||| | |.   . |..|      |  ..||||||.||||..| . | . || . . . |  .|.. .|. |  ..|.. | ...  ..      | 
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv.....tkg

LMEETGVQ
||| .|| 
lmekagvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 130-328 4.1e-25 83.3 In-house 38-230 (255) alignment 
Range on Protein: 130-328
Range on HMM: 38-230/255.0
EKTCADFWYMCYQDKVEYIFMLCNLLEKGARKCFEYFPSKKGDVMDFEEggqkISVKCESsvtysfrSDAKANVTATEIVIE-GPGEKTRKTTHYHWNDW
  | . |. .  | | | . |||.. |.|  || .||| .| . . ...    ..| .         | |.  . . ||. . |   ||.. .||... |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGW

PDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
...  |     .|..|  .| || ..|||||.||||. . |. |..  ...      . .. |  ..| ..|..|. .|.|  |  |   ..|...  |.
ieknaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

LMEET
 .|. 
eleak
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 130-341 3.3e-10 33.1 In-house 128-331 (346) alignment 
Range on Protein: 130-341
Range on HMM: 128-331/346.0
EKTCADFWYMCYQDKVEYIFMLCNlLEKGARKCfeyfpskkGDVMDFEEGGQKISVKCESSVTYSF-RSDAKAnvTATEIVIEGPGEKTRKTTHYH--WN
|    ||||| ||.... ....    .|               ... |.|| . . |       .    | |    . |.. ||  .      |.|  |.
esfvedfwymiyqeqihlvylmvp.ddklkntt........tslfndenggyqytgkmfinnrradvsgdpke..ytievlpegnsdsvicqvhhhapwk

--DWPDRGVPAADMAVLELLENARPSKGPIVVhCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKKL
  . | . .|   |    | |.   . |  ||    | ||. | .   | ..||  | |  .  .|. .|..||  .... |||  .. ....|  .|. 
hlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnng.iepniceimknikqqrpggvesfaqyasiyaivfdyiarkrg

MEETGVQEAYDAFLEQY
  .. |.   . |... 
gkkapvnkdinrfidel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 190-322 1.1e-09 32.3 In-house 200-341 (347) alignment 
Range on Protein: 190-322
Range on HMM: 200-341/347.0
SVTYSFRSDAKANVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMAVLELL----ENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL
.|.   |. .  |  . |.| ||  | |  .  |    || .  |     || |.     .. .|       . |.|| |  |. |. .||.   |..|.
avevdqrnknwmnkytvevvaegcseatf.akvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqv

LAGQIiDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
|.|.   | .... |.|.||   .     | .  .  | |.. |
ldgkt.pdcddlfkkmrdqragvftmsifytyairaalfylklk
0048076 (Phosphotyrosine protein) phosphatases II 199-318 2.4e-22 74.6 In-house 26-142 (145) alignment 
Range on Protein: 199-318
Range on HMM: 26-142/145.0
AKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQllaGQiiDDGEKILVKIR
.. ..|.   .   .   .|. ..|.. .|||.|||   .  ...||..|.|....||..||||||.||||..|.. |.| .    .   . |..| ..|
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll...lg..vsleealelvr

EQRNNSIQTDAQYLFVHQVILNY
.|| ...... |. |.....| .
sqrpgavpnpgqlrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 216-318 2.6e-16 54.0 In-house 87-193 (440) alignment 
Range on Protein: 216-318
Range on HMM: 87-193/440.0
KTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKIREQRNNSIQTDAQYLF
..|   .||.. |||.|||     ||.....        ..||..|||||| |||| .. .. |. .    . ||    ..  .|..| . .||  || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyaf

VHQVILNY
||...|. 
vheavleg
0048179 (Phosphotyrosine protein) phosphatases II 217-313 2.6e-20 68.1 In-house 46-139 (144) alignment 
Range on Protein: 217-313
Range on HMM: 46-139/144.0
TRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllAGQiiDDGEKILVKIREQRNNSIQTDAQYLFVHQ
.|  ..|.. .|||.|||   .   ..||..|.|....||..||||||.||||..|..  ..      .   . |..|  .|..| ...... |. |...
eregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgqlrfLle
PTEN_1 217-270 5.4e-08 27.9 In-house 91-149 (196) alignment 
Range on Protein: 217-270
Range on HMM: 91-149/196.0
TRKTTHYHWNDWPDRGVPAADMAV--LELLENARP---SKGPIVVHCSAGIGRTGSVVM
 ..   |.  ...| |.|  ..    .. .....    ... ..||| ||.||.| ||.
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
Y_phosphatase3 Tyrosine phosphatase family 217-271 6.1e-06 21.3 Pfam-A 94-144 (164) alignment 
Range on Protein: 217-271
Range on HMM: 94-144/164.0
TRKTTHYHWNDWPDRGvPAADMAVLELLENarpSKGPIVVHCSAGIGRTGSVVML
.... . . .. ...   .|  .|||.| .   ..||...||.||  ||| |..|
aeeamaeayreilede.kkayrkvlealae...eegpvlfHCtaGKDRTGvvaal
PTPc_DSPc_SM00012 220-316 8e-30 98.5 In-house 2-104 (105) alignment 
Range on Protein: 220-316
Range on HMM: 2-104/105.0
TTHYHWNDWPDRGVPAADMAVLELLENARPSKG------PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQ
 .|||...||| |||    ..||||.. . .|       |.|||||||.|||| .|.|.....|| ...  .| ..|. ..|.||....||..||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VIL
..|
all
0038934 (Phosphotyrosine protein) phosphatases II 220-308 1e-08 30.6 In-house 67-166 (194) alignment 
Range on Protein: 220-308
Range on HMM: 67-166/194.0
TTHYHWNDWPDRGVPAADMAVLE------------LLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQLLAgqiidDGEKILVKIREQRNNSI
.. |. ......|.   .. . .             |.      .. ..| ..||| ||.|||| .|   |..  |       . |. .  .|| |...|
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.....saeeAialfrekRpgai

QTDAQY
..  ..
pnqdyl
subfamily_PTPDC1_pd Subfamily PTPDC1 223-318 4.2e-10 34.4 In-house 85-175 (182) alignment 
Range on Protein: 223-318
Range on HMM: 85-175/182.0
YHWNDWPDRGVPAADM--AVLELLENARpSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLagqiidDGEKILVKIREQRNNSIQTDAQYLFVHQVILNY
..   |.| ||.. .    .  ... |  ..| . ||| || |||| ..    .  . |      ..|| . ..|..| .||||  |  .|..  |  
vynfgwkDygvasleriLdivkvvafal.qegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksiqtreqvelvkefalfl
subfamily_DSP19_pd Subfamily DSP19 229-298 2.1e-08 28.6 In-house 67-130 (152) alignment 
Range on Protein: 229-298
Range on HMM: 67-130/152.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQLLAgqiidDGEKILVKIREQR
|.  . .   ..|. .|.|| ..| ..|||.||. |. |||.  |.| .  .     . |. | ..||.|
petdllsylkealdFieearskdgavlvHCnAGvSRsasvvi.aylmkkeel.....sleealelvrear
subfamily_DSP1_pd Subfamily DSP1 229-277 6.6e-07 23.6 In-house 73-120 (163) alignment 
Range on Protein: 229-277
Range on HMM: 73-120/163.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
|.  . .  . |.| ..... ..| . .|| ||| |  ..... |.| .
pkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla.ylmkt
subfamily_CDC14_pd Subfamily CDC14 233-277 3.5e-07 24.4 In-house 246-288 (328) alignment 
Range on Protein: 233-277
Range on HMM: 246-288/328.0
VPaADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
.|  |. | ..|| |  ..| |.||| ||.||||...   |.| .
tP.sdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkh
PTPc_motif_SM00404 239-276 2e-08 29.2 In-house 68-104 (140) alignment 
Range on Protein: 239-276
Range on HMM: 68-104/140.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMD
.||. .|||. ..| ..||| ||. |......  |.|.
kvldfienaekkggkvlVHCqaGvSRSatliia.Ylmr
DSPc Dual specificity phosphatase, catalytic domain 239-277 2.6e-08 28.8 Pfam-A 61-98 (133) alignment 
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |......  |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
DSPc Dual specificity phosphatase, catalytic domain 239-277 2.6e-08 28.8 In-house 61-98 (133) alignment 
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |......  |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
subfamily_DSP23_pd Subfamily DSP23 240-313 7.9e-07 23.8 In-house 73-140 (148) alignment 
Range on Protein: 240-313
Range on HMM: 73-140/148.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqiiddGEKIlVKIREQRNNSIQTDAQYLFVHQ
 ....|.|   .  . |||  | ||||...   ..  . ||      .| |  ..|..|  |..|  |   |..
fvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaa.....aeai.aevrrlrpgsvetveqeklvrd
subfamily_DSP8_pd Subfamily DSP8 240-320 8.4e-07 22.7 In-house 82-152 (159) alignment 
Range on Protein: 240-320
Range on HMM: 82-152/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQLLAGqiIDDGEKIlvkIREQRnNSIqtDAQYLFVHQViLNYFR
 .| .. |. ..| ..||. ||| |  .|. . ||| .|  .  .|.  .    ..|.| ..|  . .. |. |. |.| .
svefidkaksengrvlvhvlaGisrsatva.iayimktlems..ldeayrf...vkekr.pti..spnlnflgqL.leyek
subfamily_DSP10_pd Subfamily DSP10 240-277 7.5e-06 19.9 In-house 81-117 (159) alignment 
Range on Protein: 240-277
Range on HMM: 81-117/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQ
 || .|.|| .   ..||| ||| |  .|| . |.| .
alefieearkkgsrvLvhCqaGisrsatvv.iaYlmkh
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 241-317 7.4e-16 52.9 In-house 218-293 (297) alignment 
Range on Protein: 241-317
Range on HMM: 218-293/297.0
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILN
|| |. . | . ...||||||.||.| ||. . |...|  .  | |   || ..||||   .||  |. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlk
subfamily_DSP6_pd Subfamily DSP6 241-278 4.6e-06 20.2 In-house 83-119 (158) alignment 
Range on Protein: 241-278
Range on HMM: 83-119/158.0
LELLENARPSKGPIVVHCSAGIGRTGSVvMLEYIMDQL
.|....|| .|  ..||| ||| |.  | .| |.| .|
iefidearskkskvlvhClaGisrsvtv.tlaylmkkl
subfamily_eak_pd Subfamily eak 247-323 1.5e-08 28.4 In-house 233-309 (332) alignment 
Range on Protein: 247-323
Range on HMM: 233-309/332.0
ARPSKGPIVvHCSAGIGRTGSVVMLEYIMdQLLAGQIIDD--GEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKKK
. ||  ||.  .. |  |.|  |... .. .|. ... .    |....|....|. |. .. |. |.....|.|.....
tppsfapii.qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_CG42327_pd Subfamily CG42327 248-320 7.4e-14 46.1 In-house 244-316 (319) alignment 
Range on Protein: 248-320
Range on HMM: 244-316/319.0
RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFR
| |.||.||||| |.|||| |.  .  . .|   .   |  ...  .|..| ....|  || |...|. .| .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 251-322 6.4e-08 26.3 In-house 265-347 (349) alignment 
Range on Protein: 251-322
Range on HMM: 265-347/349.0
KGPIVVHCSAGIGRTGSVVMLEYIMDQ----------LLAGQ-IIDDGEKILVKIREQRNNSIQTDAQYLFVHQVILNYFRKK
  ...|||||| |||| .| |.....           .   .   |    |. ..| || . .|  ||. .... .|.||. |
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalk
subfamily_PTEN_pd Subfamily PTEN 254-312 2.8e-06 22.4 In-house 117-173 (184) alignment 
Range on Protein: 254-312
Range on HMM: 117-173/184.0
IVVHCSAGIGRTGSVVmLEYIMDQLLAgQIIDDGEKILVKIREQRNNSIQTDAQYLFVH
.|||| || |||| ..   |.. .||  .  ..  ..  ..| . .....  .|  .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 254-316 4.6e-06 20.9 In-house 1-62 (69) alignment 
Range on Protein: 254-316
Range on HMM: 1-62/69.0
IVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKIlVKIREQRNNSIQTDAQYLFVHQVIL
.|||||.| ||||. . .   | .. . ...|  . .   .|  |   .  . .|.|.|  . 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnv.qymrkcrpmmvmneieyifihdalv