Gene daf-18 in Caenorhabditis elegans

Synonym: CELE_T07A9.6, daf-18

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP048_AA protein Get Run
CeleP048_AA_46-221 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0043336 (Phosphotyrosine protein) phosphatases II 15-223 1.1e-27 92.7 In-house 21-272 (278) alignment 
Range on Protein: 15-223
Range on HMM: 21-272/278.0
SMARDLQENPNRQPGEPRVSEPYHNSIVERIRHIFrtAVSSNRCRTEYQNIDLDCAYI----------TDRIIAIGYPATGIEANFRNS-----------
 . .. .| .. .... .... ..|    |...|.  .  ..| . .  . |||. ||          ....|| ..| .. ...|..            
llllefeellsfkldtysiallpenkdknrykdil..pydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivm

--------------------------KVQTQQFLTrrhgKGNVKVFNLRGGYYYDADNFDGN-VICFDMTDHHPP-SLELMAPFCREAKEWLEaDDKHVI
                          .| .. . .    .....|..|.  ...|   . .. . .... ||. | ||.|.  |.....|.|| |.....
LtelvelgrvkcaqYwpggsltygdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpv

AVHCKAGKGRTGVMICALLIY----INFYPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYY
.|||.||.||||..|...|..     .  ... ......   |    . |. ||| |..|..
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR...pgavqtpsqyrflyea
subfamily_VSP_pd Subfamily VSP 43-238 2.6e-45 148.9 In-house 10-209 (212) alignment 
Range on Protein: 43-238
Range on HMM: 10-209/212.0
ERIRHIFRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHgKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPS
...... |  || |. | . . .||| .|.|.||||. .|..| .. .||   .  .|| ..| . . ||.||     ||   |. .|.   . ||  |.
rklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkh.rdhykvvnlcseraydekyfnnrvkriliddhnvpk

LELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNN-----KGVTIPSQRRYIYYYHKLRERELNYLPLR
|| .  |..|.|||||.| |.|.|.||| |||||| ..||||.. . . . .. |||..  ||...     .||  |||.||. |.... ..  . || .
leellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppa

M
 
k
0039614 (Phosphotyrosine protein) phosphatases II 48-224 1.1e-28 96.1 In-house 24-285 (297) alignment 
Range on Protein: 48-224
Range on HMM: 24-285/297.0
IFRTAVSSNRCRTEYQNI----------------------------------------DLDCAYI-----------TDRIIAIGYPATGIEANFRNSKVQ
 ...| |......|....                                        |||. ||           |...|| ..| ..  ..| .   .
llekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

TQ---------------------------------QFLTRRHgKGNVKVFNLRGGYyYDADNFDGNVICFDMTDHHPP-SLELMAPFCREAKEWLEAD-D
 .                                  .|.  | .....|..|.  . ..   .   . .... ||..| ||||.  |.....|.|... .
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

KHVIAVHCKAGKGRTGVMICALLIY----INFYPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYYH
.....|||.||.||||..|.|.|..     .  ... ......   |   ...|..||| |..|.. 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR...pgavqtpsqyrflydal
subfamily_PTEN_pd Subfamily PTEN 49-230 4.2e-82 269.6 In-house 2-182 (184) alignment 
Range on Protein: 49-230
Range on HMM: 2-182/184.0
FRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHgKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAP
.|..||....|......|||..|||..|||.||||...||..|||. ....||...| |...|..|||....||...|||.|......||.||.|||...
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkh.kdhykiynlrserkydskkfdgrvavypfdDhnppplellee

FCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERE
.......|||.|.|.|..||||||||||||.|.|.|............|.... .||||.|||||||||||..||.|| |.|
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
0042113 (Phosphotyrosine protein) phosphatases II 53-225 2.6e-26 87.9 In-house 21-240 (245) alignment 
Range on Protein: 53-225
Range on HMM: 21-240/245.0
VSSNRCRTEYQNIDLDCAYI----------TDRIIAIGYPATGIEA--------------------------------------NFRNSKVQTQQFLTrr
  ..| .    . |||. ||          |...|| ..|...  .                                      .. . .|..  . .  
ydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseeh..

hgKGNVKVFNLRGGY-YYDADNFDGNVICFDMTDHHPPS-LELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIY----INFYPSPRQILD
  .....|..|.  . ..|   .. .. .... ||..|. |||.  |.......|..|......|||.||.||||..|.|.|..     .   |. ....
..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavk

YYSIIRtknNKGVTIPSQRRYIYYYHK
..   |    . |..||| |..|....
elrsqR...pgavqtpsqyrflyeall
0044763 (Phosphotyrosine protein) phosphatases II 57-227 7.6e-22 73.2 In-house 11-170 (178) alignment 
Range on Protein: 57-227
Range on HMM: 11-170/178.0
RCRTEYQNIDLDCAYITDRIIAIGYPAtgieanfrnskVQTQQFLTRRHGKgnvKVFNLRGG--------YYYDADNFDGNVICFDMTDHHPPS-LELMA
  . .     ... .|...... ..|.           ..  ..| . . .    . ||..         . |. .... ..... . ||..|. || . 
nleglersdyinaseilpglylgslpp...........addlellkelgit...hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehfl

PFCREAKEWLEaDDKHVIAVHCKAGKGRTGVMICALLIYINfypsPRQILDYYSIIRTKNNkGVTIPSQRRYIYYYHKLR
 |..  .|.|. .......|||.||.||.|....| |.. .       . . .. .| . . .|. |.|.|..|....  
efvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....glsleeaielvrerRp.ivpnpgqlrqLyefelrl
0040438 (Phosphotyrosine protein) phosphatases II 58-260 2.1e-26 88.4 In-house 47-308 (317) alignment 
Range on Protein: 58-260
Range on HMM: 47-308/317.0
C-------------RTEYQNIDLDCAYI----------TDRIIAIGYPATG--------------------------------------IEANFRNSKVQ
.             .    . |||. ||          ....|| ..|  .                                       . .. . .|.
nrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvt

TQQFLTrrhgKGNVKVFNLRGGYYYDADNFDGNVICFDM-TDHHPP-SLELMAPFCREAKEWLEaDDKHVIAVHCKAGKGRTGVMICALLI-----YINf
.... .    ........|.  ...| . .  .....   .||..| |..|.  |.....|.|| |......|||.||.||||..|.|.|.     . . 
llseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.

YPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQLIGVYVERPPKTWGGGSKIKV
 ... ......   |   ...|. |.| |..|...    .  ..|.  ..|.  ..... . .....|.|.
gvdveeavkelreqR...pgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklke
PTEN_1 61-228 5.5e-42 138.8 In-house 14-193 (196) alignment 
Range on Protein: 61-228
Range on HMM: 14-193/196.0
EYQNIDLDCAYITDRIIAIG-YPATG-----IEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGY-----YYDADN-FDGNVI--CFDMTDHHPPSLELM
 . . .||..|||.|||| |  |...     .|  .|.|  . ...| .....|   |.||  ..      || .  |...|.   |...||..|||. .
alptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslsel

APFCREAKEWLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYSIIRTKNNKGvtIPSQRRYIYYYHKLRE
  .|....||| .|. ..|..||||||.||.|....|.|.| .   .... |... . |.....   .|||.|...|...|..
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella
subfamily_Auxilin_pd Subfamily Auxilin 61-226 6.9e-36 116.5 In-house 3-163 (166) alignment 
Range on Protein: 61-226
Range on HMM: 3-163/166.0
EYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHgKGNVKVFNLrGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEAD
.| . ||| .||| ||| . .|| |.|  ..|.  . ..||  || ... .|.|| ..  |....... |.   .. .. |.|| .   ||.   ||..|
syakndlDisyitsriivmsfPaegvestyknniddvrsfLesrh.pekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

DKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNkgvTIPSQRRYIYYYHKL
 |.|. |||| |.  ..|...|||.... ...| . .. .|. |.  .     ||..||..|  .|
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladl
subfamily_Tensin_pd Subfamily Tensin 62-233 1e-39 129.0 In-house 6-179 (189) alignment 
Range on Protein: 62-233
Range on HMM: 6-179/189.0
YQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKgNVKVFNLRGgYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADD
 ...|||  |||.||||. .||.| |...|..  .  ..| ..|.. .. ||||     || .... .|. |   |.. |||| ..  |.. ..||.|| 
eekvdldltyiteriialsfpaegleekyrenlkdvakllkskhnd.kylvfnlse.krydisklnkkvldfGWPdllaPsleklcsicksldsWlkadp

KHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNK--GVTIPSQRRYIYYYHKLRERE--LNY
..|..|||| ||||.||.. | . | .   |  . || ... |  ..|  |.| ||||||. |. .| . .  || 
qnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklns
0037934 (Phosphotyrosine protein) phosphatases II 62-225 3.4e-27 91.0 In-house 32-239 (243) alignment 
Range on Protein: 62-225
Range on HMM: 32-239/243.0
YQNIDLDCAYITDRIIAIGYPATGIEANfrnskvQTQQFLTRRHGKGNVKVFNLRGGY------------------------------------------
   |...  |.|.|.|| ..| ..  ..       . .|.   .  |   . .|.  .                                          
sdyinanliyvtprliatqgPlpetved......dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen

--YYDADNFDGNVICFDMTDHHPPS-LELMAPFCREAKEWLEA-------DDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKnnK
  ..|   .. .. .. . ||..|.  | .  |..|..|..|.       |......|||.||.||||..|.|.|.. ..  .. ......   |    |
ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg..k

GVTIPSQRRYIYYYHK
.|..|||.|..|....
avqtpsqyrflyeall
0038934 (Phosphotyrosine protein) phosphatases II 63-225 4.4e-31 103.4 In-house 7-168 (194) alignment 
Range on Protein: 63-225
Range on HMM: 7-168/194.0
QNIDLDCAYITDRIIAIGYPATG-----IEANFRNSKVQTQQFLTRRHgKGNVKVFNLR-GGYYYDADNFDGNVI---CFDMTDH-HPPSLELMAPFCRE
....    .||.|.||...|..|     ||   |.|     ..|. .. .....| .|.  . |||.. | .. |    . . |. ..||||..  |.. 
lkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylklln.vklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldl

AKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILDYYSIIRtknnkgvtiPSQRRYIYYYHK
..|.|..| ..|.|||||||.||||....| ||| . . |... .......|         |.. ... |.. 
vdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdylea
0046846 (Phosphotyrosine protein) phosphatases II 63-226 2.3e-29 97.8 In-house 6-171 (176) alignment 
Range on Protein: 63-226
Range on HMM: 6-171/176.0
QNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRrhgkGNVKVFNLRGG--------YY--YDADNFDGNVICFDMTDHHPPSLELMAPFCRE
   |||. ||....|. ..|... .   |.     ....      |   |.||           ..   .  ...  ...... ||..|.|||.  ....
lgldldldyinanlilgsrpiatqgplprtladflemlkel....gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellef

AKEWLEADdkHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKnnKGVTIPSQRRYIYYYHKL
 .|.|...  ....|||.||.||||....|.|.. ..  |. ..|...  .| .  . |. |.|.|..|....|
irealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefell
0041856 (Phosphotyrosine protein) phosphatases II 63-229 2.5e-29 97.6 In-house 8-172 (182) alignment 
Range on Protein: 63-229
Range on HMM: 8-172/182.0
Q-----NIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRgGYYYDADNFDG---NVICFDMTDHHPPSLELMAPFCREAK
.     . ..|. ||...... ..||| ..|  .. . .. .||.  .. |   . ||. ...|.....     ..... . ||..|.|. .  |..|..
sdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieevl

EwleadDKHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYYHKLRER
|     ......|||.||.||||....| |.. .   |........   |   ...|..|.| ......  .. .
e.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqlallelll
0045098 (Phosphotyrosine protein) phosphatases II 64-225 2.9e-22 74.8 In-house 4-269 (278) alignment 
Range on Protein: 64-225
Range on HMM: 4-269/278.0
NIDLDCAYITDRIIAIGYPATGIEANFRNSKV--------------------------------------------------------------------
. .||. ........ |.| .  .|......                                                                     
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------QTQQFltrrhGKGNVKVFNLRGGYYYDAD--NFDGNVICF-DMTDHHPPSLE---LMAPFCREAKEWLE--------
                       .....     ..  . .....  .....|  ..  .....  . ||..|||.    .  .... .|.|.        
ekcaqywpeggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

----ADDKHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYSIIRTKNNK-GVTIPSQRRYIYYYHK
     |......|||.||.||||....| |.. .. ..   .|.... .|.. .   |....| |..|... 
slllldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefll
0036282 (Phosphotyrosine protein) phosphatases II 66-226 1.4e-37 124.5 In-house 9-168 (174) alignment 
Range on Protein: 66-226
Range on HMM: 9-168/174.0
DLDCAYITDRIIAIGYPATgIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVI
.||  |||.|.|| ..|..   . ... ...|   |.. . .|..|..|.   ...|  ... ..... . ||..|.|. .  |.....|.|. |.....
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKL
.|||.||.||||....|.|.. . ..|....||..  .|... ..|..|||.|..||..||
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0043147 (Phosphotyrosine protein) phosphatases II 66-228 5.1e-28 93.3 In-house 12-161 (172) alignment 
Range on Protein: 66-228
Range on HMM: 12-161/172.0
DLDCAYITDRIIAIGYPatgieanFRNSKVQTQQFLTRRHGKGnvkVFNLRgGYYYDADNF---DGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDK
.||. ||.||.||  .|       .||   .  ..| ... .    ..||  . .||....   .  .... . ||..|.|||.  |..  .|.|  ...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith...ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellalspg

HVIAVHCKAGKGRTGVMICALLIYINFypsprQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRE
....|||.||.||||....|.|.. ..      ... .. .|.| ...|..|||.|..||..||. 
gpvlVHCsaGvgRtgtlvaaylmllgl.....sleeavalvrekRpgavqnpsqyrflyyfeklll
0046845 (Phosphotyrosine protein) phosphatases II 66-223 1.7e-18 62.5 In-house 69-269 (284) alignment 
Range on Protein: 66-223
Range on HMM: 69-269/284.0
DLDCAYITDRIIAIGYPATG-----------------------------IEANFRNSKVQTQQF-------LTRRHgKGNVKVFNLRGGYYY-DADNFDG
|||  ||. ..||  .|  .                               | ..... .....       | . . |....|..|.  ..  .   .  
dldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtv

NVIC-FDMTDHHPP-SLELMAPFCREAKEWLEA-DDKHVIAVHCKAGKGRTGVMICALLIYINFYPS----PRQILDYYSIIRTKNNKGVTIPSQRRYIY
.... ..  ||. | |.| .  |.|...|.||. .....|.|||.||.||||..|.. |..  .          .|.... .|.. .  |. ..| |..|
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

YY
..
ea
0040439 (Phosphotyrosine protein) phosphatases II 67-224 3.8e-24 81.1 In-house 47-242 (249) alignment 
Range on Protein: 67-224
Range on HMM: 47-242/249.0
LDCAYITDRIIAIGYPATGIEANFRNSKVQTQ-----------------------------------QFLTRRHgKGNVKVFNLRGGYYYDADNFDGNVI
.|. ||..|.|| ..| ..  ..|..   . .                                   ..|   . |....|..|.  ..|| . .  ..|
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhi

CF-DMTDHHPP-SLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLI-----YINFYPsprqILDYYSIIRTKNNKGVTIPSQRRYIYYY
.. |. ||. | |.| .  |.......||.. ......|||.||.||||..|.|.|.     . . ..    ...... .|.. ...|. |.| |..|..
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd....leeavkllrsqRpgavqnpeqyrflyea

H
 
l
0051082 (Phosphotyrosine protein) phosphatases II 68-224 8e-25 82.6 In-house 7-148 (151) alignment 
Range on Protein: 68-224
Range on HMM: 7-148/151.0
DCAYITDRIIAIGYPATgieanfrnskvqtqQFLTRRHGKGNVKVFNLRGGY--YYDADNFDG---NVICFDMTDHHPPSLELMAPFCREAKEWLEADDK
.. |.|..... |.|                .||   .  |   ..|||. .  .|... .     .|... ..|...|.|.|. ....|. |.|.....
nfsyvtgglyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVIAVHCKAGKGRTGVMICALLIYINfyPSPRQILDYYSIIRTknnkGVTIPSQRRYIYYYH
....|||.|||||||......|.. .   |. ..|..| ..|.    ||..|.| .......
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfa
0045450 (Phosphotyrosine protein) phosphatases II 68-223 3.8e-22 74.8 In-house 106-299 (307) alignment 
Range on Protein: 68-223
Range on HMM: 106-299/307.0
DCAYI----------------------------------TDRIIAIGYPATGIEANFRNSKVQTQQFLTrrhgKGNVKVFNLRGGYY-YDADNFDGNVIC
. ..|                                  .....|  .| .| | ...| .| .  . .    .....|..|.  .. ..   .  ....
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh....ldgytvrtlevtdldgtgesrtvthfh

F-DMTDHHPP-SLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIYINFY-------PSPRQILDYYSIIRtknNKGVTIPSQRRYIYY
. .  ||. | |.| .  |..|....||.. ......|||.||.||||..|.|.|.. ..        ..........   |    ..|. |.| |..|.
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflye

Y
.
a
0049772 (Phosphotyrosine protein) phosphatases II 69-231 3.8e-25 84.7 In-house 121-281 (314) alignment 
Range on Protein: 69-231
Range on HMM: 121-281/314.0
CAYITD---------------------RIIAIGYPatgieanfrnskvqtqQ--------FLTrrhgkgnvkvfnlrgGYYYDADNFDGNVICF---DMT
. .|                        .|. |..                         .|                . .||.. | ...| .   ...
vrdivmsrdevladelsrLdaAlgKtpllildgng................neptaadlellk...............eelydpelferlgikylripvp

DHHPPSLELMAPFCREAKEWleaDDKHVIAVHCKAGKGRTGV-MICALLIYINFYpSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLREREL
|...|.|| .  |..  .|.   |......|||||||||||. ...|.|.. . . |....|...  .|. | . ..|.....|..... |.|.  
Dgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_PTPDC1_pd Subfamily PTPDC1 89-211 4.8e-12 40.7 In-house 41-159 (182) alignment 
Range on Protein: 89-211
Range on HMM: 41-159/182.0
NFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVIC---FDMTDHHPPSLELMAPFCREAKEWLEADdkhVIAVHCKAGKGRTGVMICALLI
.| .|....   | ..    .    . ..|. || ...  . |    | ..|.  .||| .    . ..  |. .    .|||| ||.|||||.|.. |.
kfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylv

YINFYPSPRQIldyySIIRTKNNKGV
| . . . . |    ...| |  | .
yakrltaekai....klvrskrpksi
0048179 (Phosphotyrosine protein) phosphatases II 90-225 9.6e-22 72.7 In-house 12-142 (144) alignment 
Range on Protein: 90-225
Range on HMM: 12-142/144.0
FRNSKVQTQQFLTRRHgKGNVKVFNLRGGYYYDADNFDG-NVICFDMTDHHPPSL-ELMAPFCREAKEWLEadDKHVIAVHCKAGKGRTGVMICALLIYI
...|   .... . ..  |   |.||. .|...   . | ....... ||..|.| ||.  |..  .|.||  ......|||.||.||||....| |.. 
ylgslptaldlellkk.lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkk

NFyPSprqILDYYSIIRTKNNKGVTIPSQRRYIYYYHK
.   |   . . .  .|...  .|. |.|.|....|.|
lg.ls...leealalvrsrrpgavpnpgqlrfLleyek
0049260 (Phosphotyrosine protein) phosphatases II 103-226 2.2e-26 87.7 In-house 30-148 (152) alignment 
Range on Protein: 103-226
Range on HMM: 30-148/152.0
RRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYinfypSPRQILDYYSI
...| . . . . .   ...  ..  ..... . ||..|.|. . .|. .. |.|  |......|||.||.||||....|.|..         ...... 
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.....lgvsleeaval

IRTKNNKGVTIPSQRRYIYYYHKL
.|.|....|. |.|.|..|...||
vrekRpgavpnpgqlrflyefekl
0048076 (Phosphotyrosine protein) phosphatases II 107-225 1.8e-20 68.5 In-house 28-140 (145) alignment 
Range on Protein: 107-225
Range on HMM: 28-140/145.0
KGNVKVFNLRGGYYYDAdNFDGNVICFDMTDHHPPSL-ELMAPFCREAKEWLEADdkHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYsiiRT
 |   |.||    ..   ... ....... ||..|.| ||.  |..  .|.|...  ....|||.||.||||....| |.. .   |. ..|...   |.
lgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllg.vsleealelv...rs

KNNKGVTIPSQRRYIYYYHK
.  ..|. |.|.|..|....
qrpgavpnpgqlrflyefel
0051299 (Phosphotyrosine protein) phosphatases II 107-222 2.2e-18 62.1 In-house 159-280 (288) alignment 
Range on Protein: 107-222
Range on HMM: 159-280/288.0
KGNVKVFNLRGGYY--YDADNFDGNVICFDMT---DHHPPS-LELMAPFCREAKEWLEaDDKHVIAVHCKAGKGRTGVMICALLIYINF-YPSPRQILDY
.....|..|.  ..  .| |..  .|. | .|   ||. |. .||.  |.|.....|. .......|||.||.||||..|...|..  . .     .|..
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

YSIIRTKNNKGVTIPSQRRYIYY
.  .|.. .  |. |.| |..|.
vkrlreqRpgmvqtpeqyrfvye
0051429 (Phosphotyrosine protein) phosphatases II 112-225 4.2e-12 41.8 In-house 49-222 (272) alignment 
Range on Protein: 112-225
Range on HMM: 49-222/272.0
VFNLRGGYYYDADN-----FDGNVICFDMTDHHPPSLELMA------------------------------------------------PFCREAKEWLE
...||. .......      . ....... |...|. ...|                                                  ..|. |.| 
ivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellelll

AddKHVIAVHCKAGKGRTGVMICALLIYINFY---------PSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHK
.  .. . |||.|||.|||.....||.. ..           .   ...... .| .  . |  . |....| . .
d..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall
subfamily_DSP11_pd Subfamily DSP11 120-198 9.5e-09 29.4 In-house 69-151 (178) alignment 
Range on Protein: 120-198
Range on HMM: 69-151/178.0
YYDADNFDGNVICF---DMTDHHPPSLELMAPFCREAKEWLE--ADDKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILD
||. ...  . . .    .. |. |. ||.  |... ||.||  .|....|.|||  |  ||| .||  ||  . | .|.. ..
yykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy.epedaie
subfamily_RNGTT_pd Subfamily RNGTT 120-186 2e-07 24.9 In-house 67-137 (189) alignment 
Range on Protein: 120-186
Range on HMM: 67-137/189.0
YYDADNFDG---NVICFDMTDHHP-PSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIY
|||.....    . . .... .   |. | .. | .  .|. .   ..||.|||. |  ||| .|.. |. 
yYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLve
subfamily_CDC14_pd Subfamily CDC14 120-220 2.2e-07 25.1 In-house 223-316 (328) alignment 
Range on Protein: 120-220
Range on HMM: 223-316/328.0
YYDADNFDGNVIC-FD--MTDHHPPSLELMAPFCREAKEWleaddKHVIAVHCKAGKGRTGVMICALLIYiNFYPSPRQILDYYSIIRTknnkGVTIPSQ
 ||| .|  . .   |  . |   || ...  | . |..      .  |||||||| |||| .| . |.. ..  .  ... .  |.|     |. |  |
lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmk.hyrftaaeaiawlricrP....Gsvigpq

RRYI
....
qkfl
subfamily_PRL_pd Subfamily PRL 129-189 1.2e-06 22.7 In-house 57-117 (151) alignment 
Range on Protein: 129-189
Range on HMM: 57-117/151.0
NVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINF
.|. . . |  .|. |..  . .  ||  . . |...|||| || ||. |...  ||   .
evldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm
0047943 (Phosphotyrosine protein) phosphatases II 130-223 2.9e-18 61.8 In-house 171-267 (273) alignment 
Range on Protein: 130-223
Range on HMM: 171-267/273.0
VICFDMTDHHPP-SLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIY----INFYPSprqILDYYSIIRTKNNKGVTIPSQRRYIYYY
. ...  ||. | ||| .  |.......|||. ......|||.||.||||..|...|..     .  ..   .|...  .|..   .|. |.|.|..|..
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd...vleavkllrsqRpgmvqtpeqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 132-226 1.8e-15 52.5 In-house 175-275 (297) alignment 
Range on Protein: 132-226
Range on HMM: 175-275/297.0
CFDMTDHHPPS-LELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIYINF----YPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHK
...  ||..|.  . .  |.......|..  ..... |||.||.||.|..|.| |..  .    .     ||...  .|.. .  |. ..| |..|..  
ytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

L
 
e
PTPc_DSPc_SM00012 132-224 2.1e-13 45.7 In-house 7-103 (105) alignment 
Range on Protein: 132-224
Range on HMM: 7-103/105.0
CFDMTDHHPP-SLELMAPFCREAKEWLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFYPSP--RQILDYYSIIRTKNNKGVTIPSQRRYIYYYH
. ...||. | . . .  ..|. |.. .. . .. . |||.|| ||||..... ... ... .    .|... . .|.. .. |.   |  ..| ..
ytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
0050432 (Phosphotyrosine protein) phosphatases II 134-223 3.8e-14 48.2 In-house 206-294 (308) alignment 
Range on Protein: 134-223
Range on HMM: 206-294/308.0
DMTDHHPPS-LELMAPFCREAKEWLeadDKHVIAVHCKAGKGRTGVMICALLIYINF-YPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYY
.  ||. |. .| .  |.......|   ....|.|||.|| ||||..|...|..  . .     .....  .|.. .  |. |.| ...|..
nWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra
subfamily_DSP23_pd Subfamily DSP23 134-186 3.2e-07 25.1 In-house 58-108 (148) alignment 
Range on Protein: 134-186
Range on HMM: 58-108/148.0
DMTDHHPPSLELMAPFCREAKEWLEadDKHVIAVHCKAGKGRTGVMICALLIY
 . |.|||.|| .  | |  .|  |   .  ..|||  |.|||| |.   |. 
riddyhppaleqvvefvrvveeaee..kneavsvhcllgrgrtgtmlacylvk
0048567 (Phosphotyrosine protein) phosphatases II 135-205 2.5e-09 31.7 In-house 44-119 (157) alignment 
Range on Protein: 135-205
Range on HMM: 44-119/157.0
M-TDHHPPSLELMAPFCREAKEWLE--ADDKHVIAVHCKAGK---GRTGVMICALLIYINFYpSPRQILDYYSIIRT
.  |. |..| .   |.. ....|.     ...||||||||    |||...|.. ||... . .|........|.| 
fffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf.tpeeaiaplrivrp
subfamily_PTPRB_pd Subfamily PTPRB 137-222 5.1e-06 20.7 In-house 191-277 (293) alignment 
Range on Protein: 137-222
Range on HMM: 191-277/293.0
DHH-PPSLELMAPFCREAKEWL-EADDKHVIAVHCKAGKGRTGVMICALLIYINFYPspRQILDYYSIIRT-KNNKGVTIPSQRRYIYY
||  | . . .  |.|. .|.. .. .|. | ||| || ||||. |.   .  .     ....| ..|.   .... . . ....||. 
dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifi
Y_phosphatase Protein-tyrosine phosphatase 138-221 3.3e-07 25.3 Pfam-A 146-230 (235) alignment 
Range on Protein: 138-221
Range on HMM: 146-230/235.0
HH-PPSLELMAPFCREAKEWLeADDKHVIAVHCKAGKGRTGVMICALLIYINFYP-SPRQILDYYSIIRTKNNKGVTIPSQRRYIY
|  | | . .  ..|. ...  ..... . |||.|| ||||..... ..  ..   .  ..|.. . .|.. .. |.  .|  ..|
hgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly
Y_phosphatase Protein-tyrosine phosphatase 138-221 3.3e-07 25.3 In-house 146-230 (235) alignment 
Range on Protein: 138-221
Range on HMM: 146-230/235.0
HH-PPSLELMAPFCREAKEWLeADDKHVIAVHCKAGKGRTGVMICALLIYINFYP-SPRQILDYYSIIRTKNNKGVTIPSQRRYIY
|  | | . .  ..|. ...  ..... . |||.|| ||||..... ..  ..   .  ..|.. . .|.. .. |.  .|  ..|
hgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 138-222 1e-06 23.1 In-house 191-277 (319) alignment 
Range on Protein: 138-222
Range on HMM: 191-277/319.0
HH-PPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMiCALLIYINFYpSPRQILDYY---SIIRTKNNKGVTIPSQRRYIYY
|  | .. ..  . .. ..  |  ..  | ||| || ||||   ..| . ..   .  ..|| .   | .||. |  |  |.| ..||.
hdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtf.ivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiye
subfamily_PTPRK_pd Subfamily PTPRK 144-225 9.8e-07 22.9 In-house 193-272 (314) alignment 
Range on Protein: 144-225
Range on HMM: 193-272/314.0
ELMAPFCREAKEWLEAdDKHVIAVHCKAGKGRTGVMiCALLIYINFYPSpRQILDYYSIIRTK-NNKGVTIPSQRRYIYYYHK
. .  . |. |.. |  ..  | ||| || ||||.  .|. | ..     ....| . ...|  ..|   .  . .|.. |  
tgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf.iaidivldmier.egvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 146-227 5.2e-07 24.0 In-house 197-277 (318) alignment 
Range on Protein: 146-227
Range on HMM: 197-277/318.0
MAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMiCALLIYINFYPSPrQILDYYS---IIRTKNNkgVTIPSQRRYIYYYHKLR
.  . |..... .  ....|.||| || |||||  .|. | ..      ...| .     .|.. |  . .  . .|.. |. | 
lldlvrqvskaqqksgagpivvhCsaGvGrtGvf.iavdillerikae.alvDvfqtvkqlreqrn..lmvqtedqyefiydvll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 148-226 9.8e-06 19.7 In-house 199-275 (315) alignment 
Range on Protein: 148-226
Range on HMM: 199-275/315.0
PFCREAKEWLEADDkHVIAVHCKAGKGRTGVMIcALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKL
 . | .| . ...    | |||.||.|||| .| .|   ..     . |  |  | . ..|.   . .  .| . |  |
nlirtvkqhhtnsv.gaivvhcsaGvGrtGtfi.tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 149-230 3.8e-06 21.0 In-house 198-277 (315) alignment 
Range on Protein: 149-230
Range on HMM: 198-277/315.0
FCREAKEWlEADDKHVIAVHCKAGKGRTGVMICALLIyINFYpSPRQILDYYSIIRT-KNNKGVTIPSQRRYIYYYHKLRERE
. .| |   .  ... . ||| || |||||.| .  . ..     .. .| . .... ....   . .. .| . |  ..|  
likevkad.ngkkefsllvhcsaGvGrtGvvisidev.vaqi.krtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 234-530 4.8e-31 98.7 Pfam-A 2-134 (134) alignment 
Range on Protein: 234-530
Range on HMM: 2-134/134.0
LPLRMQLIGVYVERPPKT-WGGGSKIKVEVGNGSTILFkpdpliisksnhqreratwlnncD----------TpnefdtgeqkyhgfvskRAYCFMVPED
 |.|..| ....|..|.   .|| |.||.| ||.. .|                       .          .                 ||..|.|.|.
npkrlelksiilegiPnfktrggckpkvkvyngkkkvf.......................kelasykdster.................raktfivkep

APVFVEGDVRIDIREIGfLKKFSDGKIGHVWFNTMFACDgglngghfeyvdktqpyigddtsigrkngmrrnetpmrkidpetgnefespwqivnppgle
 ...|||||.... . .  |. .. ||..|||||.| ..                                                             
nrlpveGDvlveflhkd.sklpkkekifrvwFNTsFiek.............................................................

khiteeqamenytnygmipprytiskilhekhekgivkddyndrklpmgdksytesgksgdirgvggpfeipykaEEHVLTFPVYEMDRALKS--KDLNN
                                                                           ...|||.|..|.|.|||   | ...
...........................................................................nqnvltlpkneLDkalkdkdkkfsk

GMKLHVVLRC
..|...|...
nfkvelvfek