Gene eak-6 in Caenorhabditis elegans

Synonym: CELE_F10G8.4, eak-6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily eak
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP050_AA protein Get Run
CeleP050_AA_18-311 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 5-314 1.1e-49 164.9 In-house 13-293 (297) alignment 
Range on Protein: 5-314
Range on HMM: 13-293/297.0
REDENIFMFLCEKWILINKNHIWNRINQRINIIADfdryqrartISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQR--NPLGYINASVAEFPEI-GRHY
 .  ... .|. .. . .|.....   . .... |         .|.... ||...| |   .|||.. | |..     ... |||||  ..... .|..
piplsvldlllllekansktllllefeellslkpd.........ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

IITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIeKSDKYFPNNTReelKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLP
|.|.. ..  .  ||.||.||....|||| . ||||  | ..|.|...    ..| . .|.... ...   .| |||. ..|...|.|. ..|| ... |
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvp

-KYEDFMAFYNTMKEVGVPLlavmknncmssffkkyhhtPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQH
   |... |.. ..|.   |                   |. .  .. || |  |.|.||.......... .    ....  . ..|..|...  | .| 
pslellleflelvrealael...................pkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqy

SFIYDIIIKYIRTRH
 |.||..........
rflydallellkrkl
subfamily_eak_pd Subfamily eak 6-337 1.3e-207 682.8 In-house 1-332 (332) alignment 
Range on Protein: 6-337
Range on HMM: 1-332/332.0
EDENIFMFLCEKWILINKNHIWNRINQRINIIADFDRYQRARTISEGQRTENIHRNIYGAVPYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGA
|||||||||||||||||||||||||||||||.||.|.|||...|||..|.|...||....||||..||.|||.|.|.|||||||.|||.|.||.||.||.
edenifmflcekwilinknhiwnrinqrinivadlddyqrllsisetarleavnrnvvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGi

AQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDF
|.......|||||.||||||||.|||||||..||||||||..|||||||||.|...||||||||||.||||.|.|||||.|.|||..||||..|||||||
asedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedf

MAFYNTMKEVGVPLLAVMKNNCMSSFFKKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDI
.|....||||||.||.|||....||..|||.||||..|||||...|.||.|||..||.||.||||..||.||.|...|||.|||.||.|...||||||.|
lalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyei

IIKYIRTRHNQLRHLEKYLEAHANTVRMIDST
...|...|.|.||.|.|||||.|..||..||.
vldyllrrnnrlrdlkkyleayaesvrvkdss
0045450 (Phosphotyrosine protein) phosphatases II 9-311 5.1e-50 166.3 In-house 8-305 (307) alignment 
Range on Protein: 9-311
Range on HMM: 8-305/307.0
NIFMFLCEKWILINKNHIWNRINQRINIIADFDRYQrARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQR--NPLGYINASVA--------EFPEIG
 | .   ....|...  ..... . .. . ..  .    ..|.... ||...| |   .|||.. | |.|..   .. .|||||          ... ..
fidalkllllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

RHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNtREELKFGIYDITCKEFVKRNILEYRLLEVS---VGNETHQVHHYKFHGW
|..|.| . ..  .  ||.|..||.. .|||| |.|||| || ..|.|.. .||| .| . .|.... . . . .| |||.     .|...|.|. ..||
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

TEFNLPKY-EDFMAFYNTMKEvgvpllavmknncmssF--FkkyhhTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNS-YSIEWWMLKVRSKRN
 ....|.. |.. .|.. ...                .        .|. .  .. || |  |.|.||...... ..... . . ....  . ..|..| 
pdhgvppsfeelldfieevrk................alee.....lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRp

HSALTNQQHSFIYDIIIKYIR
..  . .|  |.|........
gavqnpeqyrflyeallelll
0050432 (Phosphotyrosine protein) phosphatases II 14-314 8e-52 171.8 In-house 22-303 (308) alignment 
Range on Protein: 14-314
Range on HMM: 22-303/308.0
LCEKWILINKNHIWNRINQRINIIADFDRYQRA---RTISEGQRTENIHRNIY-GAVPYDYNLVNLtstqRNPLGYINASVAEFP--EIGRHYIITGAAQ
  .|. ...  ..... ... .. . | ....    ...| ... ||...| |   .|||.. | |     .. .|||||   ..   . |..|.| .  
sslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPl

DTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTR-EELKFGIYDITCKEFVKRNILEYRLLEVSV--GNETHQVHHYKFHGWTEFNLPKY-E
.. .  ||.||.||... |||| . || |.|| ..|.|...  . |..| . .|...  ...   .| ||..   ..|...|.|. ...| ... | . |
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspe

DFMAFYNTMKEVGvpllavmKNncmssffkkyhhtpptNAPIIQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIY
....|.. ....        ..                .  .. || |  |.|.||..|.|.....    .  ...  . |.|..|...  | .|. |.|
illdflelvrksl.......pg................gpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylfly

DIIIKYIRTRH
.....|.... 
ralleylklkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 15-200 1.8e-13 44.8 In-house 11-204 (305) alignment 
Range on Protein: 15-200
Range on HMM: 11-204/305.0
CEKWILINKNHIWNRINQRINIIADFDRYQRARTISEGQRTENI--HRNIYGAVPY-DYNLVNLTstQRNPLGYINASVAEFPEIG-RHYIITGAAQDTQ
 |...|   .   ... . .  .| . | . .... . ... .|   .| |  ||  | ..|.|   . .|  || |     | |  . .| .    |  
veqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkld..kpspsdyihanyvgcpmipekrficaqgpldqt

IPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTRE--ELKFGIY--DITCKEFVKR-NILEYRLLEVSV-GNETHQVHHYKFHGWTEFNLP
|  || || ..|   ||||   ||||  |  .|.|    |  ||| ||   ...    ..| . ..  ||...  |...  | | ..  | .  .|
idefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 16-310 1.2e-14 48.6 In-house 7-279 (303) alignment 
Range on Protein: 16-310
Range on HMM: 7-279/303.0
EKWILINKNHIWNRINQRINIIADFDRYQRaRTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTqrnplGYINASVAEFPEiGRHYIITGAAQDTQIPFF
.|| |. |. . .  |  .| . .   |    ..|  |  .|...| .   .  |.  |.|. .      || ||  |.    .. |.|          |
qkwkllakrtldedaniavnefekvvsylp.psvsknqfvknmdknrfvdvicldhskvklsds.....syihasylelds.skkailtqlplshtaadf

WQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNtREELKFGIYDITCKEFVKRNILEYR-LLEVSVGNETH--QVHHYKFHGWTEFNLPKYedfmafynt
|||. |||   ...|| | |      |  ||.| .. |||    |   || . .. .   |  .|| | ..   .| .... |   ..|           
wqmiieqkvkcvlllltdseydklggdsvfprn.qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsd.........

mkevGVPLLaVMKNNCMSSFFKKYHHTPPTnapIIQCSTGGARCGVFIIIDILINLIDNrIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
    | | . | .   . |...|| .. ||   .    .|  |.| | ...     . .  ..|  .   . .||  | |..    | |..| .. ...
....gspkf.vkqiwqlqsvlrkysdstpt...vymslsgcgragtfalfetahlslhs.eqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 20-317 3.2e-28 93.5 In-house 11-284 (315) alignment 
Range on Protein: 20-317
Range on HMM: 11-284/315.0
LINKNHIWNRINQRINIIADFDRYQRARtiseGQRTENIHRNIYGA-VPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQM
..|||.    ... .. . | | |..      .. |.| ..| |.  .|.| . | |   . .|   |||||  .  .  . || . . ... .  ||.|
fvnknrhtalfseefhdlpdPdiyrqrv....aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrm

VFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDfmafyntmkevgv
|...|  .|||. .  |    |  .|.|..  .  .|| . ..  .         | | .  ..|...|  ..|..| .   .|                
vlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts.............

PLLAVMKNNcmssffkKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQL
 || ..|.        |  . . . . .. ||.|  | ||.| ||  .. | ..  .|  .   . ..|.|| .   |.....||||.. ...  |   .
sllklikev.......kadngkkefsllvhcsaGvGrtGvvisidevvaqikrt..rsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntli
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 22-312 4e-10 33.7 In-house 17-281 (439) alignment 
Range on Protein: 22-312
Range on HMM: 17-281/439.0
NKNHIWNRINQRINIIADFDRYQRARTISEGQRTENIHRNIygaVPYDYNLVNLTSTQRNPL-GYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFE
||. |.. | . || .    . . . .  | ..| | ....   ...|.  | |  .   |   ||||   .     . || | . .. .   ||..|.|
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdv...gafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlvie

QKSPAIVMLLEDVElgiekSDKYFPNNtrEELKFGiyDITCKefVKRNI--LEYRLLEVSVGNETHQVHHykfhgwtEFNLPKYedfmaFYNTMKEVGVP
.|.  |||| . ||     | ||.| .  .|  .|  ||. .  | |||   .| .  . | ||  . ..       |  . ..      | .  .  ||
kktvtivmltnlve.....sykywpsd..aevcyg..diavr..vdrnielpnyvirgfkvfnerdttek.......ertvlqf.....hyiawpdknvp

LLAVMKNNCMSSFFKKYHHtPPTNAPIIQCSTGGARCGVFIIIDILINLIdnRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRT
  |    . . .      .   .   ...||.|  | |  | .|| .. .  ...|   |.  .  .| .|..   .  |. |||. ... |  
aqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeql..klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy
subfamily_PTPN1_pd Subfamily PTPN1 25-313 4.4e-34 112.5 In-house 6-274 (290) alignment 
Range on Protein: 25-313
Range on HMM: 6-274/290.0
HIWNRINQRINIIADfdryqrARTISEGQRTENIHRNIYGAV-PYDYNLVNLTSTQRnplGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKS
. .. | . |.  |.        ...| .. ||  .| |  | |||.  ..| ...     |||||. |..|. |.||.|       .  |||||.||||
rlykeiyldirkeas......dfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqks

PAIVMLLEDVELGIEKSDKYFPNNTR-EELKFG--IYDITCKEFVKRNILEYRL--LEVSVGNETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMKEVGv
 |.||| . || .  |  .|.|.. . .||..    . ..  .  ...    ||  ||    .||... |...  |..| .|.    |. |   ..| | 
kavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresG.

pllavmknnCMSSffkkyHHTPptnaPIIQCSTGGARCGVFIIIDILINLIDNRIK-NSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR
         ..||     .. |    ..| ||.|  | | |...| .. ||... . .|  |.  .|..|. |     | .|  | |  |.. ... 
.........slss.....dvGp....avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 25-313 1.8e-15 51.5 In-house 7-280 (287) alignment 
Range on Protein: 25-313
Range on HMM: 7-280/287.0
HIWNRINQRINIIADfDRYQRARTISEGQRTENIHRNIYGAV-PYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKS
.. . ... .. . . |    . |  . . . ....| |. | |.| . | |. . .    ||||      .    .| . .   . .  ||..|.|..|
rvkddvdkevdalke.dsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrs

PAIVMLLEDVELGIEKSDKYFPNNtREELKFGIYDITCKEFVKRN----ILEYRLLEVSvGNETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMKEvgvp
 .....  .|| .  |  ||.|.. .  .. | | ..  .. ...    .  .||...  ..|.. |. ...  | .  |.     .. |   .|.    
asvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidle.trearvvkqldllswPdkvlaPtavglirfvldvkq....

llavmknncmssFFKKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNsySIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR
            . .    .  .  ... ...|  | |... . .|..   .  .    .   ....| .|.    .  |  ..|. .. | .| 
............hielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrv..dvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_PTPRN_pd Subfamily PTPRN 28-308 6.7e-22 72.5 In-house 29-290 (297) alignment 
Range on Protein: 28-308
Range on HMM: 29-290/297.0
NRINQRINIIADFDRYQRARTIseGQRTENIHRNI-YGAVPYDYNLVNLTS-TQRNPLGYINASV-AEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSP
.|.... . .....  ......  ... .|...|    ..||| . |.|.. ....   |||||.  .       || | .   ...  |||||.|| . 
drlekewealcayeaepstkev..akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

AIVMLLEDVELGIEKSDKYFPNNTREElkFGIYDI-------TCKEFVKRNIleyrLLEVSVGNETHQVHHYKFHGWTEFNLPKYEdfmafyntmKevgv
 ||.| .  | |... ..|.|..  |   ..||..        |.... | .     |     .||  |  ..|  |.| . |            |    
vivnltrleeegvkqckrywpdeGsev..yhiyevhlvsehiwcddylvrsf....ylknlqtsetrtvtqfhflswpeegvPasa.........k....

PLLAVMKN-NcmssffKKYHHtpPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIK
.||   .  |      | |     . . .. || |  |.||.|.||...| . . .|.   |   . ..| .|..   |..|  |..  ...
sllefrrkvn......ksyrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvke.idiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 31-314 1e-17 58.7 In-house 23-240 (392) alignment 
Range on Protein: 31-314
Range on HMM: 23-240/392.0
NQRINIIADFDRYQRArtisEGQRTENIHRNIYGA-VPYDYNLVNLTSTQ-RNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVM
 . .  . . | |...     .|.  |...| |.  .||| . | |   .  .   |.|||  .  .  . || . . . . .  ||.|||...  .|.|
feefhdlpgpdiypqt....vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

LLEDVELGieksdkyfpnntreelkfgiyditckefvkrnileyrllevsVGNETHQVHHYKFHGWTEFNLPKYEDfmAFYNTMKEVgvpllavmknncm
. .  |                                             |.... |  ..|  | . ..||.    .. . .|||             
vtklkegd..........................................kgddartvaqfhftewPdkdvpkhts..sllkfikev.............

SSFFKKYHHtpPtnaPIIQCSTGGARCGVFIIIDILINLIDnrIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
.. | .| |  |    ||.||.| .| || | || ..            .  .. ..| || .   |..|..|||  ... .  | 
kadfGqyth..p...liihcsagvgrtgvvisidsvvahak..ktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn
0040438 (Phosphotyrosine protein) phosphatases II 33-336 1.2e-52 174.5 In-house 20-302 (317) alignment 
Range on Protein: 33-336
Range on HMM: 20-302/317.0
RINIIADFDRYQRArTISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLL
  .   |.....   |.|.... ||...| |   .|||.. | |....  ....|||||  ..|...|..|.|.. ..  .  ||.||.||..  |||| 
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

EDVELGIEKSDKYFPNntREELKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGvpllavmknnc
| .||| ||...|.|.  .|.|..| . .|...... .  ..| |||.   ..|...|.|. ..||.....|   ... .| . ..|.            
eleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal...........

mssffkkyhhTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIknSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRHLEKYLEAH
           .| .  .. || |  |.|.||.......... .    ...|  . ..|..|...  | .|  |.||....|......     |..|. .
..........edpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkll

ANTVRMIDS
 ... .. .
klliplald
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 34-150 9.6e-09 29.1 In-house 26-144 (302) alignment 
Range on Protein: 34-150
Range on HMM: 26-144/302.0
INIIADFDRYQRARTISEGQR--TENIHRNIYGAVP-YDYNLVNLtstQRNPLGYINASVAEFPEIGRHYIITGAAQ-DTQ--IPFFWQMVFEQKSPAIV
... ..|.. .  ..  |  .   .|...|    || .| ||| |   . .|  |.|||  | ||..|  |..  .. |..  .  ||.|||..|   .|
aevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkl...eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLLEDVELGIeKSDKYFPNNTRE
.|. . ||     ...||... .
ilvgeeelkk.tlselfpkksgd
subfamily_PTPN6_pd Subfamily PTPN6 35-315 1.9e-39 130.5 In-house 27-302 (306) alignment 
Range on Protein: 35-315
Range on HMM: 27-302/306.0
NIIADFDRYQRA-----RTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRNPLGYINASVAE--FPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAI
..  .|.. |.       . .||...|| ..| | . .|.| . | |.. .     ||||.. .  ...  ..|| |  . .| .. ||.||....|  |
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

VMLLEDVELGIEKSDKYFPNNTREELkFGIYDITCKEFVKRNILEYRLLEVS---VGNETHQVHHYKFHGWTEFNLPKyeDFMAFYNTMKEVGVPLLAVM
||. ..|| | ||  .|.|.....|  .| . .|. .  . .  ..| | ||    ..|...|..|.|. | . . ||  |  |. . ...|      ..
vmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk..dpgavLdfledvnrkqeele

knncmssffkkyhHTpPTNAPIIQCSTGGARCGVFIIIDILINLIDN-RIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHN
             ..  . . .. || |  | | ||.||||..|| .  ..  . |.  . .||. |.    |.||. |.| .| |||.|...
.............ea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 37-314 1.6e-17 58.2 In-house 31-291 (305) alignment 
Range on Protein: 37-314
Range on HMM: 31-291/305.0
IADFDRYQRARTISEGQrteNIHRNIYGAVP-YDYNLVNLtsTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVEL
.  |. ... ... | |   . ..| |  |   | | | |      |  || |     |   . .| | |  .     || | ...|  || || . .| 
mkrfndfekmkafkeaq...eagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllek

GIEKSDKYFPNNTREELKFGIYDitCKEFVKRN-ILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYedfmaFYNTMKEVGVPLLavmkNNcmsSFFKK
| .|  .||. . ...|.|   .   |  || .   .... . .  . |. |   .  | .     .|      ..   . |||      ..   . .. 
gakkcleyfaskdkdvlefeekg..qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthy.....hwidwpdrgvpaa....dl...ailel

YHHTPPTNAPI-IQCSTGGARCGVFIIIDILIN-LID-NRIKNSysiEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
 ... |.  || . ||.|  | |  .... ... |.  . |...   .  . |.| .|| |  |..|. |....|..|.| ..
lekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedt...dkilqkireqrnnsiqtdaqylfvhqvilnyfrkkk
0043336 (Phosphotyrosine protein) phosphatases II 38-310 3.3e-48 159.9 In-house 27-277 (278) alignment 
Range on Protein: 38-310
Range on HMM: 27-277/278.0
ADFDRYQRaRTISEGQRTENIHRNIYG-AVPYDYNLVNLTST-QRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVEL
 ......   |.| ... ||...| |   .|||...| |...  .....|||||  ......|..|.|.. ..  .  ||.||.|.... |||| |.|||
eellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvel

GIEKSDKYFPnntREELKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGvpllavmknncmssff
| .|...|.|   .. |..| . .|.... . .    | |||.    .|...|.|| ..|| ....|   .... |.....|.                 
grvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal................

kkyhhTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIknSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
      .. .. .. || |  |.|.||....|.......    ...|  . ..|..| ..  | .|  |.|.... |.
.....edsngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 38-309 1.2e-33 111.3 In-house 19-274 (280) alignment 
Range on Protein: 38-309
Range on HMM: 19-274/280.0
ADFD---RYQRARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRnplGYINASVAEF--PE--IGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVML
| |.   | .. ..||. ...||...| |   .|||   |.|....     ||||.  ..  |   .  .||.|    ..    |||||.||||  ||||
aqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

LEDVELGIEKSDKYFPNnTREELKFGIYDITCKEFVKRNILEYRLLEVSVGN--ETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMKEVGvpllavmknn
 . || |  |  .|.|. | .||..| ....|..  ...   .| | ..  .  | ..... ..  |.. ..|.  .||. | ......           
ttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..........

cmssffkkyhhtPPTNAP-IIQCSTGGARCGVFIIIDILINLIDNRiKNSYSIEWwMLKVRSKRNHSALTNQQHSFIYDIIIKY
              .. | .. ||.|  | ||.|.... . ||... .. | ..  . ..| .|     |..|. |. . |.| 
............sgkeePvvvhCsaGigrtGvlilletalalieaa.epvypldi.vrtmrdqramlvqtasqykfvCeailkv
0036941 (Phosphotyrosine protein) phosphatases II 39-323 3e-54 179.7 In-house 21-290 (297) alignment 
Range on Protein: 39-323
Range on HMM: 21-290/297.0
DFDRYQRARTISEGQRTENIHRNIYGA-VPYDYNLVNLtstQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGI
......   ..| ... ||...| |   .|||.. | |   . .. .|||||  ......|..|.| . ... .  ||.||.||... |||| |.|||| 
ellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgr

EKSDKYFPNNTREELKFGIYDITCKEFVK--RNILEYRLLEVSV--GNETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVGvPLLavmknncmssff
|| ..|.|....|.|..| . .|.... .   .   .| |||.   ..|...|.|. ..|| ....|  ......|.. ...|  .||            
ekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl.kll............

kkyhhtPPTNAPIIQCSTGGARCGVFIIIDILINLIDNR-IKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRHLEKY
      |. .  .. || |  |.|.||..|......... . . ..|   ..|.|..|...  | .|  |.|.......... . ...|...
......psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv
0047943 (Phosphotyrosine protein) phosphatases II 39-310 1.2e-49 164.6 In-house 17-272 (273) alignment 
Range on Protein: 39-310
Range on HMM: 17-272/273.0
DFDRY---QRARTISEGQRTENIHRNIY-GAVPYDYNLVNLtstQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVE
 |...   .   |.| ... ||...| |   .|||.. | |   . .. .|||||  ......|..|.| .  .  .  ||.||.||... |||| |.||
efelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

LGIEKSDKYFPNNTRE-ELKFGIYDITCKEFVKRNILEYRLLEVSV--GNETHQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGVpllavmknncmss
|| || ..|.|..  | .|..| . .|...  ...    | ||..    .|...|.|. ..|| ... |  .|... |.. ....               
lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale.............

ffkkyhHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
      ..|  .  .. || |  | |.||..|.|....  .  .  ...  . ..||.| ..  | .|  |.|.....|.
......alpsngpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 39-315 5.6e-33 109.0 In-house 29-285 (288) alignment 
Range on Protein: 39-315
Range on HMM: 29-285/288.0
DFDRYQRARTISEGQRTENIHRNIygaVPYDYNLVNLTSTQRNplgYINAS-VAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGI
| .  .|. .|..   . | .|.|   .||| | | | ... .   ||||| | .      ..|.| | ... .  ||.||.||||. |||||.  ||| 
dkearkrsiaiaklyseknrsrdi...lPyDhnRvklrgskDD...YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgk

EKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVG--NETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVgvplLAVMKNNCMSsffkk
.| |.|.|... |  ||| ...|.|.  . .    | |....   .....| | ... |.|. .|.  |....| . ...     .   ....       
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesa....yeavqrkskt.....

yhhtpptnaPI-IQCSTGGARCGVFIIIDILINLIdNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHN
         |. ..||.|  | ||| ..   .. . .. .    |   . ..| .| ..  ...|  | |.......|   .
.........PlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvld
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 40-312 5.6e-30 99.4 In-house 21-278 (281) alignment 
Range on Protein: 40-312
Range on HMM: 21-278/281.0
FDRYQR---ARTISEGQRTENIHRNIYGAV-PYDYNLVNLTSTQRN-PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVE
..  .      | .  .. ||...| |  .  ||   |..| ...|    ||||.  .  .  ..||.| .   . .  |||||.|||  ||||. ...|
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie

LGIEKSDKYFPNNTrEELKFGIYDITCKEFVKRNILEYRLLEV-SVGNETHQVHHYKFHGWTEFNLPKY-EDFMAFYNtmkEVgvpllavMKN-----Nc
 |  |  .|.|... .|||.| . .. ..  ...    | ...   ..|| .|.. ..  | .   |.  .... | .   ||       .|      . 
agklkChrYWPddn.selkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrk...ev.......lkltekktk.

mssffkkyhhtpptNAPIIQCSTGGARCGVFIIIDILINLIDNRiKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRT
               . .| ||.|  | |..| .| |.. .... ... ...  . ..| .||    |  |..|.| ......  
..............aplvihCsaGvGrtGtyialDrlvkaveae.leeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 40-317 6e-30 99.4 In-house 26-287 (318) alignment 
Range on Protein: 40-317
Range on HMM: 26-287/318.0
FDRY---QRARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVE
..|    ..  |  .     | ..| |   ..||   |.|. .. ..   ||||.  .  .  . || . |     |. ||.||.||.|  |||| . .|
yerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeee

LGIEKSDKYFPNNtrEELKFGIYDITCKEFVKRNILEYRLLEVSVG--NETHQVHHYKFHGWTEFNLPKYEdfmafyntmkevgVPLLAVMKNNcmssff
 | .| ..|.|..  .  ..|   .. || |. . .  | ..|.    .|. ||. |..  |.. ..|.               . ||.....       
rgkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.............aslldlvrqv......

KKYHHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQL
.|..... ... .. ||.|  | ||||..|||.. | .   .   .  .. ..|..||    |..|. ||||...... . . . 
skaqqksgagpivvhCsaGvGrtGvfiavdillerika..ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtev
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 40-204 1.1e-16 55.5 In-house 29-199 (290) alignment 
Range on Protein: 40-204
Range on HMM: 29-199/290.0
FDRYQRARTISEGQRTENIHRNIY-GAVPYDYNLVNLTSTQRN---PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVEL
.|  ..  |.  |  ..| ..| .   |.|| | . |   . .   .  ||||.  .  .  ..||.| .     .  ||... ..|...||||.. .| 
ldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniiee

GIEKSDKYFPNNTREElkFGIYDITCKEFVKRNILEYRLLEVSVGNE---THQVHHYKFHGWTEFN-LPKYED
| .|  .|.|..  ..  .| . |.  .  . |    | |||   |.   ...|..|..  | .   ..... 
gkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqt
DSPc_SM00195 41-310 1.5e-55 183.8 In-house 7-262 (263) alignment 
Range on Protein: 41-310
Range on HMM: 7-262/263.0
D---RYQRARTISEGQRTENIHRNIYGAV-PYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVEL
.   ...  ....|... .| ..| |  . ||| . |.|....  ..  ||||.. ....  ..||.| . .....  ||.||.|.|.. |||| |..| 
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

GIEKSDKYFPNNTREELKFGIYDITCKEFVKRN-ILEYRLLEVSVGN--ETHQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGVPLlavmknncmssf
| || |.|.|..  .. .|| . ....|  |..  .. | ||..  .  ||..|..|....|.. ..| . ..........|.                 
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts............

fkkyhhtppTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
         ..  ...||.|  |.|.|. |||... ...  |  ..|.... ..|..| ..  | .|..|||..|..||
.........sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 41-310 1.5e-55 183.8 In-house 7-262 (263) alignment 
Range on Protein: 41-310
Range on HMM: 7-262/263.0
D---RYQRARTISEGQRTENIHRNIYGAV-PYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVEL
.   ...  ....|... .| ..| |  . ||| . |.|....  ..  ||||.. ....  ..||.| . .....  ||.||.|.|.. |||| |..| 
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

GIEKSDKYFPNNTREELKFGIYDITCKEFVKRN-ILEYRLLEVSVGN--ETHQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGVPLlavmknncmssf
| || |.|.|..  .. .|| . ....|  |..  .. | ||..  .  ||..|..|....|.. ..| . ..........|.                 
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts............

fkkyhhtppTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
         ..  ...||.|  |.|.|. |||... ...  |  ..|.... ..|..| ..  | .|..|||..|..||
.........sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0051299 (Phosphotyrosine protein) phosphatases II 41-310 7.1e-49 162.2 In-house 33-286 (288) alignment 
Range on Protein: 41-310
Range on HMM: 33-286/288.0
DRYQRARTISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIE
 ...  .|.| ... ||...| |   .|||.. | |....  .. .|||||  ......|..|.| .  .. .  ||.||.||... |||| . |||| |
lsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgre

KSDKYFPNntREELKFGIYDITCKEFVKRNILEYRLLEVS------VGNETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVGVpllavmknncmssf
|...|.|.  .. |..| . .|... .. .   .| |||.       ..|...|.|. ...| ... |   |....|.. ....                
kcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..............

fkkyhhtPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
       .. .  .. || |  |.|.||..|.|.......  .  ...  . ..|..|...  | .|  |.|.... |.
.......sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN12_pd Subfamily PTPN12 41-315 7.9e-33 108.6 In-house 24-282 (290) alignment 
Range on Protein: 41-315
Range on HMM: 24-282/290.0
DRYQRARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIE
 . ... . ..|...||...| |   .|||.. |.|. .. ..  .||||.. . .|   .|| . .   . .  ||.|..|..   .||. . ||||  
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KSDKYFPNNTREELKFGIYDITCKEFVKRN-ILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFM-AFYNTMKEVGVpllavmknncmssffkkyH
| ..|.|... |||.|| . .|..|  . .  .  | |.| . .|...|. .... | . . |. .. . .. ....|.                    .
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..................s

HTPPTnapIIQCSTGGARCGVFIIIDILINLID-NRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHN
.  |    .. || |  | |. | ||.  .|.  ..|......   .|..| .|.    |..|....|  ........ .
edaPl...vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
0046845 (Phosphotyrosine protein) phosphatases II 43-314 1.7e-49 164.1 In-house 9-278 (284) alignment 
Range on Protein: 43-314
Range on HMM: 9-278/284.0
YQRAR-----TISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQR--NPLGYINASVAEFP-----EIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVML
...       ..| ... ||...| |   .|||.. | |.|..   .  .|||||  ...      | ...|.| .  .. .  ||.||.||... ||||
llsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVml

LEDVELGIEKSDKYFPNNtREELKFGIYDITCKEFVKRNILEYRLLEVSV---GNETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVGVPllavmkn
 | || | || ..|.|..  | |..| . .|...  ...   .| ||..    ..|...|.|. ...| ... |   ||...|.....|.          
telvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.......

ncmssffkkyhhTPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRI-KNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
            .|. .  .. || |  | |.||..|.|.......     ....  . ..|..|...  | .|  |.|.... |.....
............lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 44-311 5.6e-32 105.9 In-house 34-280 (288) alignment 
Range on Protein: 44-311
Range on HMM: 34-280/288.0
QRARTISEGQRTENIHRNIYG-AVPYDYNLVNLTS-TQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSD
.. .. . |....| ..| |   .|||.. |.|.   . .   |||||  .  .  ..|| | .     .  ||..|.|.|.  |||| | || | .| .
ektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

KYFPNNTReELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYE-DFmafyntmkevgVPLLAVMKNNCMSSffkkyhhtpp
.|.|.. . . ..|  ..| .|  . .    | |..   ..  ....|.. .|.. . |. . ..           . ||  .|..  .           
eYWPdadk.pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapl...........lellrqvkvanqad..........

TNAPIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIR
|.  |..|| |  | |.|| .| ||. ...  ..   .   . |.| .|.    | .|. |||..... | 
tgpiivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 44-310 1.5e-22 74.8 In-house 20-295 (297) alignment 
Range on Protein: 44-310
Range on HMM: 20-295/297.0
QRARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRNpLGYINASVAEFPEIGR--HYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKS
.|. . |  .|   ...| |   . .| . |.|  .  .   ||||    ||.     .||..    .. .  ||..|.||   .|||. .  | | .| 
argesfssakrnsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

DKYFPNNTREELKFGIY-----DITCKEFVKRNILEYRLLEVsvgNETHQVHHYKFHGWTEFNLP-KYEDFMAFYNT--MKEVGVPL-LAVMKNNCMSS-
  |.|.   | || | .       |  || .  . | .|.     .|. .|.| .| .| .  .|   ||   |        . ||. ||...  .    
apywpsvvqerlkagdvvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvf

-FFKKYHHTPPTNAPI-IQCSTGGARCGVFIIIDILINLIdnRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
   . ..   | ||.. . ||.|  |.|| .  |.... .  | |    .   . ..|..|     | .|. ..||...| .
lqleslraemprnayllvhcsaGvGrsGvvvlsdvilakl..rkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_PTPRB_pd Subfamily PTPRB 45-315 1.7e-32 107.7 In-house 39-290 (293) alignment 
Range on Protein: 45-315
Range on HMM: 39-290/293.0
RARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDK
. ....  ....|  .| |   .|||.. |.|....  .   ||||.  .  .  |..| |     . .  ||.||.|.|| .|||| . || | .| ..
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCee

YFPNNTReELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDfmafyntmkevgvPLLAVMKNncmssFFKKYHHTPPTN
|.|.... .  .|   .| ..  . .    | |... ..|...|..|.|  |.... |.  .             .||. ...     . .. ..|  ..
YWPadee.pvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektk.............tlldfvrt.....vreaiektaskr

APIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHN
  .. || |  | |.|| .| |.. |..  ..   |   . ..|..||.   |..|. ||.. .....|....
PivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Ptp69D_pd Subfamily Ptp69D 45-321 1.6e-28 94.7 In-house 36-299 (307) alignment 
Range on Protein: 45-321
Range on HMM: 36-299/307.0
RARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQ-RNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDK
  .. . ... ||  .| | . ...| . | |. .. ..   |||||  .  .  ...|.  .  .. |  ||.|. ||..  |||| .  |   .| .|
idkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcak

YFPNNtrEELKFGIYDITCKEFVKRNILEYRLLEVSVG-------NETHQVHHYKFHGWTEFNLPKYE-DFMAFYNTMKEVGVPLlavmknncmssffkk
|.|..  .| ..|   ... .. | .    | |.||         .....|  |.. || ... |.     . . . ..|.                   
YWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...............

yhhtpptNAPI-IQCSTGGARCGVFIIIDILINLIdnRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR--HNQLRHLE
       ..|| . ||.|  | |.|. .|.|.. .  .  .. .|   . ..||.||      .|..|.|  ...|.      .....||
.......rsPivvhCsaGvgrsgifvaldsllqql..kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 45-314 1.3e-26 88.5 In-house 34-287 (305) alignment 
Range on Protein: 45-314
Range on HMM: 34-287/305.0
RARTISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDK
.  .|  |....| ..| .   ...| . . || .. ..   |||||  .  .   .||.. .  .. .  ||....| |   |||| . || | .|  .
eeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrq

YFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSV---GNETHQVHHYKFHGWTEFNLPKYE-DFMAFYNTmkeVgvpllavMKNncmssffkkyHHT
|.|....|. .|| . .. |.. . . .  | |..|.    .|...| .|..  | .   |..   .. ...    |       .|.          .. 
YWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikr...v.......qkd..........qkk

PPTNAPIIQCSTGGARCGVFIIIDILINlidnRIKNSYSIEWW--MLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
    . .. || | .| |||| .|| ..    |.|.  ... .  . ..||||     | .|  |..|.. ..| . .
dkgvpllVhCsagvgRtGvfiavdiale....rlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 45-203 3.3e-19 64.2 In-house 44-204 (298) alignment 
Range on Protein: 45-203
Range on HMM: 44-204/298.0
RARTISEGQRTENIHRNIYG-AVPYDYNLVNLTS-TQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDK
.. . . ....|| ..| |   ...|.  | |..  . .   ||||| ..  .    .|.| |   . .  ||.|| |... .|||| . .||.  |  |
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YFPNNTREelKFGIYDITCKEFVKRNILEYRLLEVSVG--NETHQVHHYKFHGWTEFNLPKYE
|.|..  |  ..|  ... ..  .   |. | |.||    .....|.. .|  |..   |...
ywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena
subfamily_PTPRD_pd Subfamily PTPRD 46-323 7.7e-37 122.2 In-house 37-296 (564) alignment 
Range on Protein: 46-323
Range on HMM: 37-296/564.0
ARTISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKY
  |... .  .| ..| |   |.|| . | |....  .   |||||  .  .  ..|| | .   . |  ||.||.||.|  |||| . .| | .| .||
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

FPNNtReELKFGIYDITCKEFVKRNILEYRLLEV--SVGNETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMKEVGvPllavmknncmssffkkyhhtPP
.|.. . . ..| . .| .| .. .  | | ...  .  .|...|....|  | . . |.. ...... ......  .                    | 
WPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e....................pd

TNAPIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLR--HLEKY
.   ...|| |  | |.||.||.... | .  ..   |   . ..|..||.   |..| .||...| ...   .....  .|.. 
agPivVhCSaGVGRTGtfividamlerike..ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh
subfamily_PTPN13_pd Subfamily PTPN13 46-310 6e-25 83.0 In-house 26-269 (273) alignment 
Range on Protein: 46-310
Range on HMM: 26-269/273.0
ARTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRnplgYINASVAEFP--EIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDK
  | ..|.. || ..| |   .|||   |.| .       |||||  . |  .   .||..     . .  |||||.|||.  |.|.  ..| |  | ..
ldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchr

YFPNNTREELKFGI-YDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLPKYEDFMafyntmkevgVPLLAVMKnncmsSFfkkyHHtp
|.|......||    ....  . .|.. .  | |.|.    .|...| | .|  | . . |.  . .          . ..| ..     ..    ..  
ywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaael..........lqfvaevr.....rl....qt..

pTNAP-IIQCSTGGARCGVFIIIDILINLIDNRIknSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
  ..| .. ||.|  | |..| ||....||..    .. ..  . |.| .|.    |..|. |.| .|.. .
.dagPivvhcsaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_ptpA1_pd Subfamily ptpA1 47-273 3.1e-13 44.2 In-house 37-261 (418) alignment 
Range on Protein: 47-273
Range on HMM: 37-261/418.0
RTISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQ-RNPLGYINASVAEFpEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYF
   |||..  |  .| |   .| ..  |.|   | ..   ||||   .     ...| |       |  ||.||.|..   ||||  . |    | |.|.
setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PNNTREE---------LKFGIYDITCKEFVK---RNILeYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDfmAFYNTMKEVgvpllAVMKNNCMSSFF
|..   |           || | .   | ..   |.|.  | . ...  ||... .|.. || ..|.| . .   | . .. .     .  .|. . |  
peqiggeqfsiygngnevfgtysvelveviqdpereii.trnirltfegetrditqyqyegwpdhnipdhtq..pfrqllhsi.....tnrqnqiipssd

KkyhhtpptNAPI-IQCSTGGARCGVFIIIDILINLIDNRIK
.        | || ..||.|  | | |    |... .|  .|
r........nvpiivhcsagvgrtgtfctavimmkkldhyfk
0040439 (Phosphotyrosine protein) phosphatases II 48-311 7e-46 152.2 In-house 2-247 (249) alignment 
Range on Protein: 48-311
Range on HMM: 2-247/249.0
TISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQR-NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFP
..|.... ||...| |   .|||.. | |....  .. .|||||. ... |.|..|.|..  .  .. ||.|..|... .|||| ..|||| || ..|.|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NntREELKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKevgvpllavmknncmssffKKYHHTPPTN
.  ...|..| . .|.... . . .  | ||..    .|...|.|. ...| ....|   ||...|.. ..                   | ....|. .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr...................kaleelpkgg

APIIQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIR
  .. || |  |.|.||.......... .  . ...|  . ..||.|...  . .|  |.|........
pvlVHCsaGvgRtGtfiaaylmleqleke..lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 48-313 2.1e-39 131.0 In-house 24-275 (278) alignment 
Range on Protein: 48-313
Range on HMM: 24-275/278.0
TISEGQRTENIHRNIYG-AVPYDYNLVNltstqrnplGYINASVAEFPeiGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPN
.|..... .|...| |   .|||.. |          .|||||  ...  ....|.| .  .. .  ||.|..|.....|||| | |||| || ..|.|.
eitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

ntREELKFGIYDITCKEFVKRNILEYRLLEVS------VGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKEVGVPLLAVMKNNCMSSffkkyHHTPP
  .. | .| . .|....   .   .| |.|        ..|.. |.|.....| ... | ..  . | . ....   | ....  ..|      .. ..
..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl.....lllds

TNAPIIQCSTGGARCGVFIIIDILINLIdnriKNSYSIEWWMLKVRSKRNH-SALTNQQHSFIYDIIIKYIRTR
 .  .. || |  | |......... |.    .. ....    ..||.|.. .  . .|  |.|. ...... .
ggpvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN14_pd Subfamily PTPN14 48-312 2.3e-38 126.9 In-house 40-298 (300) alignment 
Range on Protein: 48-312
Range on HMM: 40-298/300.0
TISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQRNPLGYINASVAEFP--EIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYF
..| ..  || ..| .   .||. | |.|..|. |  ||||||  . .     |.||.. . ... .  |||||.||.   |||| |. | | ||| |||
llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

PNN--TREELKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVgvpllAVMKNNCMSSffkkYHHTP
|..   .....|| . .| |   . . .  . |..     .|  .|.| ..  |.. ..|.  ..|. . . .. |         |. ..|     .. |
PkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsv.....rrktnseves....keskP

PtnaPIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRT
|    .. || |. | || |. |.||. ...   ..  |.  . ..| .| .   |  |. |.|...|||.. 
P...vlvhCsaGvGrtGvlilsdlliatleh..neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_PTPN9_pd Subfamily PTPN9 48-312 1.8e-29 97.7 In-house 33-292 (297) alignment 
Range on Protein: 48-312
Range on HMM: 33-292/297.0
TISEGQRTENIHRNIYGAVP-YDYNLVNLTSTQRN-PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFP
|.   .   |...| |  |  ||   |.|.... .    ||||.  .  .  . .| |  . .  .  ||.||.||.   |||    || |  |  .|.|
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

NNTREELKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMKEVGVpllavMKNNCMSSFFKKYHHTPPTn
... .  .|| . ..  | ....  . | ||..    .|. .| |..| .| ..  |.  .... . ....|        .  . ...  |   . ||  
leeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa.....lavkelgdewkghpsgPPi.

apIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRT
  .. ||.|  | | || .|| .. ...  ..   .   . ..|..| .|  |..|. | |  .. |  .
..vvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_PTPRG_pd Subfamily PTPRG 48-319 5.7e-27 89.2 In-house 38-296 (563) alignment 
Range on Protein: 48-319
Range on HMM: 38-296/563.0
TISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQR--NPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYF
...  |..|| ..| |   |.||   |.|...    . | ||||.  .  . .. .|.|  .  . .  ||.|..||..  |||. . || | .| | |.
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PNNTREELK-FGIYD----ITCKEFVKRNILE-YRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKevgvpllavmknncmssffkkYHHT
|... |... . .      ...   |.. ...  .| . .  .. ..| .|..  | . . |... .   .   .                        .
PkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.....................saan

PPTNAPI-IQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRH
. .  || . ||.|..| |..|..| |.. | .  .|.  .   . ..|..||.   |. |  |..|.... |......|  
kaeaGPivvHcsaGvgrtGtyivldtllkqiqq..enavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 48-326 5.9e-26 86.3 In-house 39-301 (319) alignment 
Range on Protein: 48-326
Range on HMM: 39-301/319.0
TISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFP
|... .. || ..| |   ..||   | |.. .  .   |||||  .  .  . .| | |  .. |  ||.||.|..|  .||| ..|| .  |  ||.|
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

NNTREElkFGIYDITCKEFVKRNILEYRLLE---VSVGNETHQVHHYKFHGWTEFNLPKYedfmafyntmkevGVPLLAVMKNNCMSsfFKKyhhtpPTN
... ||  .| . .| .|  . . .. | |.    |   || .| |...  |.. . |..             .  ||...|.   |   .|     ...
eenfee..yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPek.............atslldllkrirks..rek.....tqs

API-IQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHN--QLRHLEKYLEA
 || . || |  | | ||..|. .. . .   .   .  .. ..| .||    ...|..|||....... . .   ....|.. | .
gPivvhCsaGvGRtGtfivldamlervke..egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkq
subfamily_PTPRA_pd Subfamily PTPRA 48-339 6.9e-26 85.9 In-house 49-326 (330) alignment 
Range on Protein: 48-339
Range on HMM: 49-326/330.0
TISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQRNPL-GYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFP
|.   .. || ..| .   .|||.. | |.  . ..   |||||  .  .   ..| .   ..  .  ||.|..|||| .|||| |  |   ||  .|.|
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

NN---TREELKFGIYDIT-CKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFMafyntmkevgVPLLAVMK-NNcmssffkKYHhtpp
..   |  ...  . | | ....  |..|  .| . .  ... .|. ..|..| .. .|     |          . ||. .|  |       . .    
deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGm..........lkllkkvkkln.......qqs....

TNAPIIQCSTGGARCGVFIIIDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIR--TRHNQLRHLEKYLEAHANTVRMIDSTN
... .. ||.|  | | ||..| ... .    |    .   . ..| .| .   |..|. ||| .. .|        ..  |||.|.   |..  .| . 
agpivvhcsaGvGrtGtfivldavlervkaerk..vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkig

T
 
l
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 48-167 4.3e-10 33.8 In-house 35-160 (301) alignment 
Range on Protein: 48-167
Range on HMM: 35-160/301.0
TISEGQRTENIHRNIygaVPYDYNLVNLTSTQ---RNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYF
..|| ... | ..||   ..|| | . |. ..        |||||  .     ...|.. .  .  .  ||......|  .|||. .  |   .|. .|.
glseenkalnrfkni...tvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

PNNTREELKFGIYDITCKEFV------KR
|| . |. .||   .| ..         |
pnseaeseefgpftvtlvneqvyPdfvir
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 48-152 8.5e-10 32.9 In-house 40-158 (350) alignment 
Range on Protein: 48-152
Range on HMM: 40-158/350.0
TISEGqrTENIHRNIYGA-VPYDYNLVNLTST---------QRNPLGYINASVAEFP----EIGR--HYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLE
 .|||   |   .| |   .||. . |.|  .           ..  ||||.  . .    ||    .|| | |     .  |...... | . |..| .
ilseG..velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

DVELGIEKSDKYFPNNTREEL
||||..|| ..|... . .. 
dvelnlekcyrYWqegsyddi
subfamily_CG7180_pd Subfamily CG7180 49-313 7.2e-24 78.9 In-house 34-293 (296) alignment 
Range on Protein: 49-313
Range on HMM: 34-293/296.0
ISEGQRTENIHRNIYG-AVPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIeKSDKYFPN
   | |.||. .| .   |||||| | |.. . .    ||||.  .     . ||.| | ..  .  ||..|..... |.|.| .  .    .  .|.||
CagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpn

NTREELK-FGIYDITCKEFVKRNILEYRLLEV--SVGNETHQVHHyKFHGWTEFNLPKYEdfmaFYNTMKEVGVPLLAVMKnnCMSSFFKKYHHTPPTNA
...|. . . .  .. |.. . .| ...|     .......||.  .    . |.| ..|      . .  .   |. ...   . .. .| .. | .. 
kskeqygeifveiveekqyanlkirtfkltkkivalteqekqvka.etRivklfqlteWe....ledkvPlstnalielrr..rvrlwrekvdedpeegP

PIIQCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR
 .. .| |..| ||.. ||. ..|...  ..   .   . ..| .|..   . ..  .|||.. ... . 
vvvvssdGasRsGvylaidanlelvek..eeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 49-313 5.6e-16 53.3 In-house 25-262 (267) alignment 
Range on Protein: 49-313
Range on HMM: 25-262/267.0
ISEGQRTENIHRNIYGA-VPYDYNLVNLTSTQRNplgYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEdveLGIEKSDKYFPNN
||    ..|  || .   .||| . | |  ....   |||||  |  . ....|.|  . .  |  |.... .|| | ||.|      ....  ...| .
isqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwPPk

TREELKFgiYDITCKEFVKRNILEYRLLEVSV--GNE-THQVHHYKFHGWtefNLPKyedfmafynTMKEVGVPLLAVMKNNCMSSffkkyhhtppTNAP
  .  |.   |.| .  ....  .|... . .   || .|.|  | .. |   |.             |    ||.... .| .             | |
mgqakky..qdltvehslekeendyqiitlelkfknesahnvtlyyykkw...nint.........nnkpylkplfgilaknqlen..........gnrP

-IIQCSTGGARCGVFIIIDILINLIdnRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR
 ...|| |  | | |..||  .. .  .  .   |  ...|.||.|     | ... .|.... .| . |
lvvacsdGvGrsGtflvidsqlera..ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegr
0042113 (Phosphotyrosine protein) phosphatases II 51-310 1.2e-45 151.3 In-house 3-243 (245) alignment 
Range on Protein: 51-310
Range on HMM: 3-243/245.0
EGQRTENIHRNIY-GAVPYDYNLVNLTSTQRNP-LGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNnt
 ... ||...| |   .|||...| |.... .. ..|||||   ...| ...|.|.. ..  .. ||.|..|... .|||| |..||| .|...|.|.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

REELKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKevgvpllavmknncmssffkKYHHTPPTNAPI
.|.|..| . .|.... . . .  | |||.    .|...|.|| ...| ... |   |..  |.. ..                    |. . .. .  .
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr....................kalaedsngpvl

IQCSTGGARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
. || |  |.|.||.......... .    .|.|  . ..||.| ..  | .|  |.|.......
VHCsaGvgRtGtfiaaylmleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 52-310 7.8e-35 116.0 In-house 5-242 (243) alignment 
Range on Protein: 52-310
Range on HMM: 5-242/243.0
GQRTENIHRNIYG-AVPYDYNLVNLtstqrNPLGYINASVAEFPEigrHYIITGAAQDTQIPF----FWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPn
... ||...| |   .|||.. | |     .. .||||.  . ..   ..|.|..  .  .      ||.|..|... .|||| |.|||| || ..|.| 
allpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

ntrEELKFGIYDITCKEFVKRNILEYRLLEVSV---GNETHQVHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVGVPLLAVMknncmssffkkyhHTPPTN
   .|  .| . .|....   .   .| |...    ...|..|.|| ...| ... |   ||...| . ..|.   || ..             . .. .
...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll.............aldsgg

APIIQCSTGGARCGVFIIIDILINLIdnriknSYSIEWWMLKVRSKRNH-SALTNQQHSFIYDIIIKYI
  .. || |  | |..|...... |.      ....|  . ..|..|.. .  | .|  |.|.......
pvlVHCsaGvgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 52-314 4.7e-25 83.2 In-house 4-246 (250) alignment 
Range on Protein: 52-314
Range on HMM: 4-246/250.0
GQRTENIHRNIYG-AVPYDYNLVNLTSTQ-RNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEkSDKYFPNNTR
... .| ..| |   ...|   | | ...  .   ||||| ..  .  . .|.| .   . |  ||.||.|.|| .|||| . .| . .   .|.| .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

EelKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQ--VHHYKFHGWTEFNLPKYEdfMAFYNTMKEVgvpllavMKNNCMSsffkkyhhtppTNAPI-I
|  |.|   .. ..  .   .. | | .|  .....  | ...|  | .   |..    |  . .|.|        ...  .            |||. .
e..kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPeva..tavLellkkv.......qasqqqa...........gnaPviv

QCSTGGARCGVFIIIDILINLIdnRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
|||.| .| | ||.|| ... .  ....   .   . ..| .| |.  ...|..|.| ||.|.. . .
qCsaGvgrsGafiaidavlerl..kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 52-310 2.2e-23 77.7 In-house 44-279 (315) alignment 
Range on Protein: 52-310
Range on HMM: 44-279/315.0
GQRTENIHRNIYG-AVPYDYNLVNLTSTQRN-PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNtr
 ...|| ..| |   ..||   |.|  .. .    |.||.  .  .  |.|| . . . . .  ||..|||..   |||| . ||   .|..||.|..  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

eELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYE-DFMAFYNTMkevgvpllavmknncmssffkKYHHTPPTNAPIIQC
 .. .| . .| |.  . . .  | | | .|.. ..|  ...  | . ..|||   .| .. |.                     | |||    | .. |
.kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtv.....................kqhhtnsvgaivvhc

STGGARCGVFIIIDILINLIDnrIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
| |  | | || .| ... ..  ..|   .   . .||..| .   . .|. ||||.... .
saGvGrtGtfitldavldqae..aenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
0049772 (Phosphotyrosine protein) phosphatases II 52-323 1.7e-14 49.8 In-house 41-293 (314) alignment 
Range on Protein: 52-323
Range on HMM: 41-293/314.0
GQRTENIHRNIYGAVPYDYNLVNLTSTQRNPLGYINASVAEFPeigRHYIITGAAQDTQIPFF----------WQMVF--EQKSPAIVM-----------
..  .|...| |  ..   |.| | .   .  .|||||    .   . .|.| .  .  .  |          |.||.  ....  |||           
adlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LLEDVELGieksdkyfpnntreelkfgiyditcKEFVKRNILEYRllevS-------VgneTHQVHHYKFHGWTEFNLPKYEDFMAFYNT
          ||.  ..|                          | . ... ...    .       .   .... .|. . .. .. |  ||| .|.. 
rLdaAlgKtpllildgng.........................neptaadlellk....eelydpelf...erlgikylripvpDgsaplledfdeflef

MKEVgvPllavmknncmssffkkyhhtpPTNAPIIQCSTGGARCGVFIIIDILINLIDnriknsYSIEWWMLKVRSKRN-----HSALTNQQHSFIYDII
..|.  .                     . .. .. |. |  | |.|.....|. | .      .|.|  .  ||.||      ..  . .|  ||....
ieea..d.....................kggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefileal

IKYIRTRHNQLRHLEKY
 .|... ..  ..|| .
leylkflkkfyeyleen
subfamily_PTPRK_pd Subfamily PTPRK 53-309 4.5e-27 89.7 In-house 39-276 (314) alignment 
Range on Protein: 53-309
Range on HMM: 39-276/314.0
QRTENIHRNIYGA-VPYDYNLVNLTSTQRN-PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTRE
.. || ..| .|  ..||  .| |.... .    ||||.. .  .  ...|.|    .  .  ||..|..... .|||| | || |  |  ||.|..|. 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

ELKFGIYDITCKEFVKRNILEYRLLEVS-VGNETHQVHHYKFHGWTEFNLPKYEDfmAFYNTMKEVG---VPllavmknncmssffkkyhhtpPTNAPII
  .. .  . ..   .  .  .|. ...   .|...|....| ||.... |...   .. . ...|     .                          ..
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat..gllklvrrvkksqee.....................eaGrivv

QCSTGGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKY
 ||.|. | |.||.|||....|..  ..   .   . ..||..     |..|. ||||.|.  
hCsaGaGrtGtfiaidivldmier..egvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 53-314 3e-25 83.3 In-house 39-280 (515) alignment 
Range on Protein: 53-314
Range on HMM: 39-280/515.0
QRTENIHRNIYGA-VPYDYNLVNLTSTQRNPL-GYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTRE
|   | ..| |.  .||| . | |   . ||   |.|||  .  .  . || . . ... .  ||..|....  .|.|. .  |    |  ||.|.   .
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

ELKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYedfmafyntmkevGVPLLAVMKNNcmSSFFKKYHHtpptnAPIIQCST
 .||| . .             | |.|  |.... |  ..|..| .   ||                 || ..|.    .   .| |     . || ||.
svkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh.............tssllklikev..kadhgqyth.....pliihcsa

GGARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
|  | ||.| ||  .  . .   ..  .   . ..| || .   |..|..|||...  ..  | 
GvGrtGvvisidsvvahakt..trmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 53-305 7e-22 72.6 In-house 33-261 (283) alignment 
Range on Protein: 53-305
Range on HMM: 33-261/283.0
QRTENIHRNIygaVPYDYNLVNLTSTQRnplGYINASV---AEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTR
... | ...|   ||.| . |.| |  |    ||||.    ..  . .. |||. .  |  .  ||.|||..|  ||||| .  |   .|  .|.|..  
nkrknrnqei...vpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

EElkFGIYDITCKEFVKRNILEYRLLEVSVG---NETHQVHHYKFHGWtefnlpkyedfmafynTMKEVGVPLLAVMKNNCMSSFFKKYHHTPPtnapII
|.  .| . .| .. .  | .  ..| . |    ..|  . ||.. .|                .  . . .. ...| | . |  .. ...|     ..
ed..yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW................leygeqaiinslvkfnkvislqteskkgPi....vv

QCSTGGARCGVFIIIDILINliDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDI
 ||||. | .||| .   ..  | . .    .   .  .| .|     | .|. .....
hCstgiGrtavfiaasasvk..daltesvvdvfavvkimreqrmmavqtldqyklvhel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 54-311 3.2e-16 54.4 In-house 45-289 (325) alignment 
Range on Protein: 54-311
Range on HMM: 45-289/325.0
RTENIHRNIYG-AVPYDYNLVNLTSTQRNPL-GYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMlLEDVELGIEKSDKYFPNNTREE
. ||. .| .   |..| . | | . . .|   |||||  .       .. . | . . |  .|..|.. ... .|. |. ..|| ..  .|.|..  . 
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemgks

LKFGIYDITCKEFVKRNILEYRLLEVS--VGNETHQVHHYKFHGWTEFNLPKYEDFMAFY-NTMKEVGvpllAVMKNNCMSSffkkyhhTPPtnapIIQC
 .||  ..  .   .     .| |.|    . ||  |. ... .| ..  .|.   .. . ...|.|       .. |. .|       ||     .. |
ktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs....ervtantkas.......tpi....lvhc

STGGARCGVFIIIDILInliDNRIKN-SYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIR
|.|  |.|||| .  ..   .. |.. .  |   . |.| .|     |  |...||. ..... 
saGvGrtGvfislysal...akvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 54-162 1.6e-06 21.9 In-house 93-194 (244) alignment 
Range on Protein: 54-162
Range on HMM: 93-194/244.0
RTENIHRNIYGA-VPYDYNLVNLTSTQRnPLGYINASVAEFPEIGRHYIITGAA-QDTQIPfFWQMVFEQKSPAIVMLlEdvelGIEKSDKYFPNNtrEE
  .| ..|  || .|.|.| | |.        |||||          ||.|     || .  ||.|..|..   .|.|       .|. |.|.|.   | 
npnnswknregaglpfdfnrvplskgsm.gntyinasfvgclgrtaeyiltqhpladtsmd.fwkmmlerhvnvlvvl.g....sveeedeywpds..ep

LKFGIYDITCK
|..   |||  
lewyeeditvt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 55-319 3.3e-19 64.0 In-house 45-281 (288) alignment 
Range on Protein: 55-319
Range on HMM: 45-281/288.0
TENIHRNIYGAvpyDYNLVNLTstqRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKF
|.. ..|..     |.  | |.    .|  ||.| |    .  |. | . |  .. |  .|.|..|.    |||| | .|.| |||..||| .  |. ..
trdryenlprc...ditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GIYDITCK-EFVK-RNILEYRLLEVSVGNETHQ-VHHYKFHGWTEFNLPkyEDFMAFyntmkevgVPLLAVMknncmssffkKYHHTPpTnapIIQCSTG
| .    | . .    ...  || .|   |... | .  .. | .  .|  |.....        . || |.          | .. |     ....|.|
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP..enylsp........lrllevl..........kslqkP.i...vvhssaG

GARCGVFIIIdiLINLIDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR-HNQLRH
  |.| .|.|  || |   |...  .|.  . | | .| ..  |..|. ... .. ...  . ...||.
vGrtgtlili..lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlre
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 55-148 5.4e-06 20.2 In-house 50-144 (310) alignment 
Range on Protein: 55-148
Range on HMM: 50-144/310.0
TENIHRNIYGA-VPYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNT
....|.| |   |  |   |.|.  .     || |       .   .| .    .  |  ||.|.|.... .|..|   .| |  |.  |.|   
kkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 56-315 7.9e-23 76.0 In-house 50-289 (297) alignment 
Range on Protein: 56-315
Range on HMM: 50-289/297.0
ENIHRNIYG-AVPYDYNLVNLTSTQRNP-LGYINASVAefPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVElGIEKSDKYFPNNTREElk
 |.... |   .||| . |.| ... .|   |.|||    . .  ..| |   ... .  ||.||....  .|||| .| | . .|  .|.....  .  
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddne.rdkkcaryWsdkgvtt..

FGIYDITCKEFVKRNILEYRLLEVSVGN--ETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKEVgvpllavmknncmssffKKYHHTPPTNAPIIQCSTG
||   .. .   .|.    | |||. |.   .. |. |.|  | . . .. ..  .. . ..||                 .| . .   .  .. |..|
fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisev.................rkdfsqnaegPllvhclaG

GARCGVFIIIDILINLIDNriKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHN
  | ||.. ||  .  . .  ...  |   . |.| .| .   |..|..|.| ...... . . 
vGrtgvlltidsvvaeakr..ekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 56-206 2.3e-14 48.1 In-house 46-196 (287) alignment 
Range on Protein: 56-206
Range on HMM: 46-196/287.0
ENIHRNIY-GAVPYDYNLVNLTSTQRNplgYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTReeLKF
.| ..| .   ...| . | |  .. .   ||||.  .  .  ...||. .     .  ||... ... .||||| .. |   |.  .|.|...   . .
qnkdknRltqilvpdnyrvllkgehpd...yinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvl

GIYDITCKEFVKRNILEYRLLEVSVGN---ETHQVHHYKFHGWTEFN-LPKYEDFM
| | |.  .  . .    | |||   |   ...||. |..  | .   .....  .
GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtil
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 57-330 2.9e-21 71.2 In-house 25-277 (284) alignment 
Range on Protein: 57-330
Range on HMM: 25-277/284.0
NIHRNIYG-AVPYDYNLVNLTSTQRN-PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLedvelgIEKSDKYFPNNTREelKF
|  .| .|  ...| | | |  .. .    |||||  .       || |   .|  .  ||.|..|... .||.|        .|  .|.|... .  | 
nkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi..ke

GIYDITCKEFVKRNILEYRLLEVSV-GN--ETHQVHHYKFHGWTEFNLPKYedfmafyntmkevGVPLLAVMKNncMSSFFKKYHHTPPTnapIIQCSTG
. ...  .   . .    | .|.|  |.  .  ... ..| || .   |.|             ...|....|.  .. . .| .|  .    .. ||.|
erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy.............psdlmrlvkk..vrhltskenhrani...vvhcsag

GARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR--HNQLRHLEKYLEAHANT
  | ||.|..|.|.. ...   .   .   . ..| .||.      |. |||  ...          |  .  |||  .| 
vgrtgvyivldvlldrmkee..kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 57-329 6.6e-21 69.9 In-house 61-312 (319) alignment 
Range on Protein: 57-329
Range on HMM: 61-312/319.0
NIHRNIYG-AVPYDYNLVNLTSTQRN-PLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLedvelgIEKSDKYFPNNTREelKF
|  .| ..  ...| | | |  ..      |||||  .       || .   .|  .  ||.|..|... .||.|        .|  .|.|... .  | 
nkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi..ke

GIYDITCKEFVKRNILEYRLLEVSV-GNE--THQVHHYKFHGWTEFNLPKYedfmafyntmkevGVPLLAVMKNncMSSFFKKYHHTPPTnapIIQCSTG
. ...  .   . .    | .|.|  |.|    ... ..| || .   |.|             ...|. ..|.  .. . .| .|  .    .. ||.|
erfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy.............psdlmrlvkk..vrhltskenhrani...vvhcsaG

GARCGVFIIIDILINLIDNRikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH--NQLRHLEKYLEAHAN
  | ||.|..|.|.. ...   .   .   .  .| .||.      |. |||  ...     |    .  .  |||  .|
vGrtGvyivldvlldrmkee..kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleelsn
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 57-307 1.3e-18 62.1 In-house 3-236 (237) alignment 
Range on Protein: 57-307
Range on HMM: 3-236/237.0
NIHRNIYGAV-PYDYNLVNLTSTQRNpLGYINAS-VAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNnTREELKF
|  .| || .  ||.. | |  .  .   ||||. . .|    ..|| .    ..    |||||...|   ||||   .|   .|  ||.|. | .   .
nkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaay

GIYDITCK---EFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEdfmafyntmkevgVPLLAVMKNncmssFFKKYHHTPPTNAPIIQCSTG
|.. .. |   ||    .  . | .    .|   .| |.|  | .  .|..                ||   ||       .. .| . .   || ||.|
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqt.............aallrfrkn.....iinrsphvsesgpwiihcsag

GARCGVFIIIDILINliDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIII
 .| |.|..|| ..   . . |.   |  ..  .   | .   |..|. ||.. |.
vgrtgiflvidamlr..qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 58-206 1.3e-15 51.9 In-house 38-189 (281) alignment 
Range on Protein: 58-206
Range on HMM: 38-189/281.0
IHRNIYGAVP-YDYNLVNLTS--TQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKF
 ..| |  .|  |   |.|     ..|   || |     | . | ||.|   .      ||.|...... ||||| . .|   ||  .||| |..  |.|
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqf

GIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFM
  . .. ..    . |    |..|   ||. . |. .. | ....|.  . |
dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevm
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 59-305 8.2e-14 46.3 In-house 10-236 (239) alignment 
Range on Protein: 59-305
Range on HMM: 10-236/239.0
HRNIYG-AVPYDYNLVNLTSTQRNPL-GYINASV-AEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFG
 .| |   | ||.. | |     .|   |||||   ..    . || |  .  ..   ||.|.....   ||||   .|   .|  .|.|..| .  .. 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

IYDITCKEFVKRNILEYRLLEVSVgNETHQVHHYKFHGWTEFNLPKYEdfmafynTMkevgvpLLAVMKNNCMSSFfkkyhhtPPTNAPIIQCSTGGARC
.     . |    |  . . .|    | . |..|.|  | .  .|.|        |       .| . ..    |.       | .   .|.||.|  | 
vtlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqya.......ta......vlglrrkitkdsl.......pgarpwvihcsagvgrt

GVFIIIDILINliDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDI
| |..|| ..   . . ...  |  ..  .|  | |   |..|. ||.  
gaflvidamlr..qakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 59-316 1.1e-10 36.0 In-house 43-283 (307) alignment 
Range on Protein: 59-316
Range on HMM: 43-283/307.0
HRNIYGAVPYDYNLVNLTSTQRNPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYD
..| |  |.   .   .  ..     || |         ...| .   ... .  || |. ..|  ...|| . .||.  | ..|.| .  ..| ||   
dknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap

IT-------CKEFV-KRNILEYRLLEVSVGNETHQVHHYKFHGWTEfnlpkyedfmafyntmkeVGVPLLAVMKNNCMSSFfkKYHhtppTNAPIIQCST
 |       .|..    ....   |.|  ....  ..|.... | .                   ||| . .   | ...   .|.    ||  .. ||.
ntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpd..................rgvpqinltainlleav..ryd....tnpvvvhcsa

GGARCGVFIIIDILINLIDNRiKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQ
|  |.|  . | .. . . .  .|  ...  . ..||.|...  |. |. ... ....|   .. .
GvGrsGtivaislvqdkmiaG.inckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 60-306 7.9e-14 46.4 In-house 10-236 (239) alignment 
Range on Protein: 60-306
Range on HMM: 10-236/239.0
RNIYG-AVPYDYNLVNLTSTQRNPL-GYINASV-AEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGI
.| |   | ||.. | |     .|   |||||   ..    . || |  .  ..   ||.|.....   ||||   .|   .|  .|.|..| .  .. .
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv

YDITCKEFVKRNILEYRLLEVSVgNETHQVHHYKFHGWTEFNLPKYEdfmafynTMkevgvpLLAVMKNNCMSSFfkkyhhtPPTNAPIIQCSTGGARCG
     . |    |  . . .|    | . |..|.|  | .  .|.|        |       .| . ..    |.       | .   .|.||.|  | |
tlrktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqya.......ta......vlglrrkitkdsl.......pgarpwvihcsagvgrtg

VFIIIDILINliDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDII
 |..|| ..   . . ...  |  ..  .|  | |   |..|. ||.  .
aflvidamlr..qakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 64-314 1.9e-27 90.9 In-house 28-268 (270) alignment 
Range on Protein: 64-314
Range on HMM: 28-268/270.0
GAVPYDYNLVNLTSTQRNP-LGYINASVAE-FPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKF--GIYDI
. .|     | | . . ..   ||||   . | .  ..|| . . ..| .  ||.|..|.|..||||. . .| | .| ..|.|... |..|.  |   .
diLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikv

TCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMkevgVPLLAVMKNNCmssffKKYHHTPPTnapIIQCSTGGARCGVFI
.  . .|..    . |..    |.... |. .. | .   |. ||     . .    . .|. ... .     |. ... |.   .. || |  | |..|
lalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdql....lkmlravrrse.....keldkaePl...lvHcsaGvgRtGtli

IIDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
..|| ..|.... |    .   . ..| .|     . .|  |.|  ...|...|.
alDiavrlLeetkk..vdvlaiieelRkdRmalvqhpeqyeflykavveyaerra
0041856 (Phosphotyrosine protein) phosphatases II 64-312 1.7e-21 72.1 In-house 9-173 (182) alignment 
Range on Protein: 64-312
Range on HMM: 9-173/182.0
GAVPYDYNLvnltstqrnPLGYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLedvelgiekSDKYFPnntreelkfgiyditcke
  .|||...         .| ||||..  ..  ....|.| .  . ... |..|. |..  .||.|          .. |.|                  
dilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..................

fvkrnileyrllevsvGNETHQVHHYKFHGWTEFNLPKYEDFMAFYNTMKEvgvpllavmknncmssffkkyhhtpPTNAPIIQCSTGGARCGVFIIIDI
                 ........|....|  .. |  ... .| ....|                         . .. .. || |  | |.......
................ellerlgiqylylpwpDhgvpdldelldfieevle.........................eggpvlVHCsaGvgRtgtlvaayl

LINLidnriknSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRT
.. |       ..|.|  .  |||.|...  | .|. |.....  ... 
mkkl.......gvsleeavklvrsrRpgmvitpnqyfflqlallellll
Y_phosphatase Protein-tyrosine phosphatase 66-307 2.1e-43 143.8 Pfam-A 11-234 (235) alignment 
Range on Protein: 66-307
Range on HMM: 11-234/235.0
VPYDYNLVNLTSTQR-NPlgYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCK-E
.||| . | |....  .   ||||.. .  .  ...|.| .  .  |  ||.||...|. .|||| ...| | || ..|.|....|.|..| . ...| .
lpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkek

FV-KRNILEYRLLEVSVGNE---THQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGvpllavmknncmssffkkyhhTPPTNAPIIQCSTGGARCGVF
   . .    | ||..  .|   ...|... ...|.. ..| ...... . . ...                       .. ..  ...||.|  |.|.|
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.....................eaksgpvvVhCsaGvgRtgtf

IIIDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIII
. .|||.. .... .   ..   . ..|..|...  . .|  |.|..|.
valdilleqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 66-307 2.1e-43 143.8 In-house 11-234 (235) alignment 
Range on Protein: 66-307
Range on HMM: 11-234/235.0
VPYDYNLVNLTSTQR-NPlgYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCK-E
.||| . | |....  .   ||||.. .  .  ...|.| .  .  |  ||.||...|. .|||| ...| | || ..|.|....|.|..| . ...| .
lpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkek

FV-KRNILEYRLLEVSVGNE---THQVHHYKFHGWTEFNLP-KYEDFMAFYNTMKEVGvpllavmknncmssffkkyhhTPPTNAPIIQCSTGGARCGVF
   . .    | ||..  .|   ...|... ...|.. ..| ...... . . ...                       .. ..  ...||.|  |.|.|
ekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.....................eaksgpvvVhCsaGvgRtgtf

IIIDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIII
. .|||.. .... .   ..   . ..|..|...  . .|  |.|..|.
valdilleqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 66-312 2e-25 84.4 In-house 38-270 (274) alignment 
Range on Protein: 66-312
Range on HMM: 38-270/274.0
VPYDYNLVNL--TSTQRNPLGYINASVAEFPE-IGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTRE--ELKFGIYDIT
.| .   | |   |.. . . |||| .   ..   . |. |     . .  ||.|....... |||| .  |   .|  .|||...    . ..|  .|.
lPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveik

CKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWTEFNLPkyEDFMAFYNTMKEVgvpllavmknncmssFFKKYHHTPPTNAPIIQCSTGGARCGVFII
 .. |.||  . | | ..  .....|.|| .  | . . |  .|  .. ....||                 .. ... .. . .. || |  | |.|| 
vekiverndysvrklvlkylerersvkhywytdWPdhksP..ddantlldlvlev...............eesreeenaklapvvvhCsaGiGrtGcfia

IDILINLIDNRIKnsYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRT
|.| .. ....|.    .   . ..| .|     |..|. .|. ....| . 
isiavrqlreeiv..vdvlkivcnlrldrGGmvqtseqyelihralclylkr
0044763 (Phosphotyrosine protein) phosphatases II 69-309 2.3e-13 45.7 In-house 3-170 (178) alignment 
Range on Protein: 69-309
Range on HMM: 3-170/178.0
DYNLVNLTSTQRNPLgyinASVAEFPEIGRHYIITGAAQdtqiPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTReelkfgiyditckefvkrn
| ..|.|.. .. .     .    . ||  ....... .    . ..... |..  .||.| |..||| .|.|.|.| ..                    
drtrvllsnlegler....sdyinaseilpglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

ileyrllevsvgnethqvHHYKFHGWTEFNLPK-YEDFMAFYNTMKEVGvpllavmknncmssffkkyhhTPPTNAPIIQCSTGGARCGVFIIIDILINL
                   .|.. ..  .. |  .| |..|.. ..|.                       .. .. .. || |  | |......... |
..................iqylhipipDhgvpdllehflefvefieeal.....................dekggpvlVHCsaGvgRsgtlvaaylmkkl

idnriknSYSIEWWMLKVRSKRNhSALTNQQHSFIYDIIIKY
       ..|.|  .  ||..|.    .  |  ..|..  ..
.......glsleeaielvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 81-310 1.9e-17 59.0 In-house 10-173 (176) alignment 
Range on Protein: 81-310
Range on HMM: 10-173/176.0
NPLGYINASVAEFPeigrHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELkfgiyditckefvkrnileyrllevsvg
..| ||||...  .    ..|.| .    ... |..|..|..  |.|.|.|.||||  | . |.|  .....                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

nethqvhHYKFHGWTEFNLPKYEDFMAFYNTMKEVGvpllavmknncmssffkkyhhtPPTNAPIIQCSTGGARCGVFIIIDILINlidnriKNSYSIEW
       .|....| ... | .|... ... ..|.                          .  .. || |  | |.......|.       .. .|.| 
.......qylhlpwpDhgvpdlelllellefireal......................keggpvlVHCsaGigRtgtlvaayllel......ekglsvee

WMLKVRSKRN-HSALTNQQHSFIYDIIIKYI
 . .||..|  ..  | .|  |.|. . ...
alalvreqRplgavqtpeQyrflyefellll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 81-148 6.8e-06 19.6 In-house 88-157 (349) alignment 
Range on Protein: 81-148
Range on HMM: 88-157/349.0
NPLGYINASVAEFPEIG--RHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNT
 .  ||||   ....|   ..|| | |   . .  |....  .. . .. | .| ||..|| |.|. . .
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_CG42327_pd Subfamily CG42327 82-204 1.5e-12 41.8 In-house 55-181 (319) alignment 
Range on Protein: 82-204
Range on HMM: 55-181/319.0
PLGYINASVAEFPEI-GRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNT--REELKFGIYDITCKEF--VKRNILEYRLLE
   |..||    ..    .|| . .. .     ||..|.||.|  || | .  ||||..  .|.| .    ..  .| . .| |.    .| ..   || 
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllk

VSVGNETHQVHHYKFhGWTEFNLPKYED
   ..|. .. || .  | | ..|  | 
rvdkeesrelthywy.kwleaevPaeea
0043147 (Phosphotyrosine protein) phosphatases II 84-303 9.9e-18 59.9 In-house 6-154 (172) alignment 
Range on Protein: 84-303
Range on HMM: 6-154/172.0
GYINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDvelgieksdkyfpnntreelkfgiyditckefvkrnileyrllEVSVGNET
 |||||  ... | ...|.| .  .  .. ||.|. |..  .||.| |                                            ..   ...
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpelle

HQVHHYKFHGWTEFNLPKYEDFMAFYNTMKE--VGVPllavmknncmssffkkyhhtppTNAPIIQCSTGGARCGVFIIIDILInlidnrikNSYSIEWW
... .| ...|  .. |  | .. |.. ..|  .  |                       .. .. || |  | |.........         ..|.|  
rlgiqylylpwpDhgvpllellleflefidellalsp......................ggpvlVHCsaGvgRtgtlvaaylml........lglsleea

MLKVRSKRNHSALTNQQHSFIY
.  ||.||...  . .|. |.|
valvrekRpgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 84-313 1.1e-16 56.8 In-house 5-228 (272) alignment 
Range on Protein: 84-313
Range on HMM: 5-228/272.0
GYINASVAEFPeiGR-----HYIITGAAQDTQIPFFWQMvFEQKSPAIVMLLEDVELGIEKSDKYFP----------NNTREELKFGIYDITCKEFVKRN
|||||.    .  ||      .. .|.  .  .  ||..  |..  .||.| ...|.| .| |.| |          ... ..  .| . .|. ...  .
gyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

ILEYRLLEVS---VGNETHQVHHYKFHGWTEFNLPKyEDFMAFYNTMKEvgvpllavmknncmssffkkyhhtppTNAPIIQCSTGGARCGVFIIIDILI
   .| |...     .|...|.|. ...|  .. |. | . .. . . .                           .. .. || |  | |... ...|.
dyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld..........................ggpvlvHCsaGkdRTGtvvalllll

NLID-NRIKNSYS-----IEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR
  .. . | . |      .|  . ..|..| ..  | .|  |.|.......|. 
lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 84-205 8.7e-14 46.3 In-house 47-179 (290) alignment 
Range on Protein: 84-205
Range on HMM: 47-179/290.0
GYINASVAEFPEiGRHYIITGAAQDTQ-------IPFFWQMVFEQKSPAIVMLLEDVELGIEKSD----KYFPNNTREELKFGIYDITCKEFVKRNILEY
.|| |.   .|. | . |.| . |          |  || |. . |.  .||| |  |   ..|.    ||.|..  |||||.   . ||. .| . .| 
dyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RLLEVSVGN-ETHQVHHYKFHGWTEFNLPKYEDF
| |.|  .. | ..| |....||.. | .. .  
RelvvkfddeeeftvtHsllkgWnklnvqedtkt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 84-310 3.1e-13 44.3 In-house 60-270 (285) alignment 
Range on Protein: 84-310
Range on HMM: 60-270/285.0
GYINASVAEFPEIGR-HYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVGNE
 || ||   .|   .  || |       .  ||.|....|   ..||   .| |.||   |.|..  | .||| |.||  |  .  |    |  ..| | 
dyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvint

THQVHHYKFhgWTEFNLPKYEDFMAfyntmKEVGVPllavmknncMSSFFKKYHHTPPTNAPI-IQCSTGGARCGVFIIIDIL-INLIDNRIKNSYSIew
        .      ..| . | .|      |   |         |  ..|  ..  | . || ..||.|  |   |. ||   | ...|   .   |  
edasseply..mnhvqvpwwpdqla.....pedarp.........mielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldi..

wMLKVRSKRNHSALTNQQHSFIYDIIIKYI
 . ..|. | ..  .  |  |.| ....|.
.vremramrfqavqshmqflflyvvlmeyf
0036282 (Phosphotyrosine protein) phosphatases II 85-304 9.6e-22 72.9 In-house 4-164 (174) alignment 
Range on Protein: 85-304
Range on HMM: 4-164/174.0
YINASVAEFPEIGRHYIITGAAQDtqipfFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNntreelkfgiyditckefvkrnileyrllevSVGNETH
|||||   . .| ...|....  .     ||.|..|... ..||||| .|||..|   |.|                                    ...
yinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredler

QVHHYKFHGWTEFNLPKYEDFMAFYNTMKEVGvpllavmknncmssffkkyhHTPPTNAPIIQCSTGGARCGVFIIIDILINLIDnriKNSYSIEWWMLK
 ...|.. .|  .. |  . .  |.. ..|.                       .| .  .. || |  | |......... ..     .   .  .. .
lgiqylylpwpDhgvpdlsillefvkfveeal....................sedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvre

VRSKRNHSALTNQQHSFIYD
.|..| ..  | .|  |.|.
lRlqrpgmvqtpsQyrflyy
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 85-319 4.4e-07 23.9 In-house 69-285 (312) alignment 
Range on Protein: 85-319
Range on HMM: 69-285/312.0
YINASVAEFPEIGRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTR--EELKFGIYDITCKEFV----KRNILEYRLLEVS
|| |          ....| .. .  . .|||...   | .|..|   || | ||. ||  .     .     .|   | |       .. . .|.| | 
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvv

VGN--ETHQVHHYKFHGWTEFNLPKYEDfmafynTMKEvgvpLLAVMKNNcmssffKKyhhtpPTnapIIQCSTGGARCGVFIIIDILINLIDNRIKNSy
|    .  .. ||..  | .  .|   |      | .     ||. .|..      ||     |    | .||.|  | | ...|. .|  .    |.  
vkatgqesklnhyqwaswpdhgmpdscd......talr....llsavkkd......kk.....pv...iahcsagvgrtgtlaliesmiaalrhprkqn.

sIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRHNQLRH
 .   .. .|  |  |  .  |. .   ...... ..    | 
.vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn
0051082 (Phosphotyrosine protein) phosphatases II 92-306 3e-14 48.4 In-house 7-149 (151) alignment 
Range on Protein: 92-306
Range on HMM: 7-149/151.0
EFPEIGRHYIITGAAqdtqIPFFWQMVFEQKSPAIVMLLEDVELGieKSDKYFPNNTreelkfgiyditckefvkrnileyrllevsvgnetHQVHHYKF
 |  .. .....|.      . |.... |..  .||.| ...| |  .  .|.|..                                    ..|.|. .
nfsyvtgglyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg...................................ievlhipi

HGWTEFNLPKY-EDFMAFYNTMKEvgvpllavmknncmssffkkyhhtPPTNAPIIQCSTGGARCGVFIIIDILInlIDnriknsYSIEWWMLKVRSKRN
..|....|| . . ...| . . .                        .. .  .. || |  | |.........   .      .|.|  .  .|.|| 
ldwpdpglplsfdavleflellld........................kkngpvlvHCsaGkgRTGtlvalylml..lg......vsleealeeyrlkrp

HSALTNQQHSFIYDII
..  .|||. |..  .
gvvqpnqqflfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 97-214 1.4e-13 45.3 In-house 89-212 (301) alignment 
Range on Protein: 97-214
Range on HMM: 89-212/301.0
GRHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCK--EFVKRNILEYRLLEVSV---GNETHQVHHYKF
 ...|.| .  .     || |.   .   |||| . ||  .|| ..|.| ...|.|. | ..|. |  |.. .. .  | |||       .|. | ||..
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqy

HGWTEFNLPKYE-DFMAFYNTMKE
. ||. ..||   . . . . .|.
sewtdrgvPkshaelfdlmelvkk
0049260 (Phosphotyrosine protein) phosphatases II 98-304 1.5e-14 49.4 In-house 9-144 (152) alignment 
Range on Protein: 98-304
Range on HMM: 9-144/152.0
RHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFpnntreelkfgiyditckefvkrnileyrllevsvgnethqvhHYKFHGWTEF
...|.| .  .  .. ||.|. |..  .|||| |..||| .| ..|.                                           .|... |  .
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDh

NLPKYEDFMAFYNTMKEVGvpllAVMKNNcmssffkkyhhtpptnAPIIQCSTGGARCGVFIIIDILInlidnrikNSYSIEWWMLKVRSKRNHSALTNQ
. |. .... | . . |      |  |..                  .. || |  | |.........        . .|.|  .  ||.||...  . .
gvpdlsqlllflllfiekl....aldkgg................pvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpg

QHSFIYD
|  |.|.
qlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 98-267 2.2e-11 38.3 In-house 5-161 (199) alignment 
Range on Protein: 98-267
Range on HMM: 5-161/199.0
RHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLL----EVSVGNETHQVHHYKFHG
|.|| |  .    .  |||||.|  |  |||. .|          |.|       |.|   .|.|  . .       |    ...    | .. ||.|  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WTEFNLPKYEDFMAFYNTMKEVgvpllavMknncmssffKKYHHTppTNAP-IIQCSTGGARCGVFIIIDILINL
| |   |.   |. |  . .||                 |||      .|| |..|| |    |||. .|| .  
wkekttpnvalfvgfvvasrev.......s.........kkyeqe..kdapvivhcsdgqgftgvfvaldigvrs
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 98-267 2.3e-11 38.3 In-house 4-160 (198) alignment 
Range on Protein: 98-267
Range on HMM: 4-160/198.0
RHYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLL----EVSVGNETHQVHHYKFHG
|.|| |  .    .  |||||.|  |  |||. .|          |.|       |.|   .|.|  . .       |    ...    | .. ||.|  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WTEFNLPKYEDFMAFYNTMKEVgvpllavMknncmssffKKYHHTppTNAP-IIQCSTGGARCGVFIIIDILINL
| |   |.   |. |  . .||                 |||      .|| |..|| |    |||. .|| .  
wkekttpnvalfvgfvvasrev.......s.........kkyeqe..kdapvivhcsdgqgftgvfvaldigvrs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 99-201 5e-15 49.9 In-house 95-200 (290) alignment 
Range on Protein: 99-201
Range on HMM: 95-200/290.0
HYIIT-GAAQDTQIPfFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEF-VKRNILEYRLLEVSVG--NETHQVHHYKFHGW
 .|.| || .|| |  .|.|| ..|  ||||| | .| |  | ..|.|..  | | || . ..| |   | . .  ..| |        |...|.|   |
mfiltqGalkdtvid.iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkiksw

TEFNLPK
 .  ...
pdksval
subfamily_egg_pd Subfamily egg 99-325 6.3e-10 33.2 In-house 84-289 (307) alignment 
Range on Protein: 99-325
Range on HMM: 84-289/307.0
HYIITGAAQDTQIPFFWQMVFEQKSPAIVMLLEDVELgiEKSDKYFPNNTREELKF--GIYDITCKEFVKRNILEYRL--LEVsVGNEthqvhhykfhgw
..|.. |        ||.|||... . ||||   .|   |. . |.|.   . |..  | . |.. .  ..    .|.  | . || .            
efilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd............

tefnlpK----YEDFMAFYNTMKEVGVPLLAVMKNNCMSsffkkyhhTpPTnapIIQCSTGGARCGVFIIIDI-LINLIDNRIkNSYSIEWWMLKVRSKR
      .     | .   .| . .|  ||  . |   .|        . |.   ..|.  | ....... |.| |..|.   |   . .   .  .| .|
......deerflehwqgdvnnssdvysplrvlrklrnls........k.pv...vvqdilGvskaatlvaieiallsllrGpi.tkslvlravvflrlrr

NHSALTNQQHSFIYDIIIKYIRTRHNQLRHL----EKYLE
. |  .  .. |.| ... ..|      ..|    |..||
rlsvesvllylfvyrlvlfffrdvigsakeldvdyerwle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 100-195 7.8e-06 19.5 In-house 238-329 (440) alignment 
Range on Protein: 100-195
Range on HMM: 238-329/440.0
YIITGAAQDTQIPFFWQMVFEQKSPAIVMLLedvELGIEKSDKYFPNNTREeLKFGIYDITCKEFVKRNILEYRLLEVSVGNETHQVHHYKFHGWT
.| |    |. .  ||..| . .  .|.||    .|       |.| |||  . || . .  |   . | .  | ||.   .| |..  ..   | 
fiatqmpldstvldfwrlvhdyristiimln...qlndktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwp
subfamily_hpo-7_pd Subfamily hpo-7 110-202 7.2e-14 46.3 In-house 46-140 (263) alignment 
Range on Protein: 110-202
Range on HMM: 46-140/263.0
QIPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVG--NETHQVHHYKFHGWTEFNLPKY
.|. |.|..  .|.  .||| .  | |.|| ..||| .  | .|.   .... . ..  .|  . |   .|   .||.|.||.. || | | |. 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 111-202 1.3e-15 52.2 In-house 41-134 (255) alignment 
Range on Protein: 111-202
Range on HMM: 41-134/255.0
IPFFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEFVKRNILEYRLLEVSVG--NETHQVHHYKFHGWTEFNLPKY
.  |.|..  .|.  .||| .  | |.|| ..||| .  | ||.   ..|. . .   .|  . .   .|   .||.|.||...|| | | |. 
vdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 113-310 5e-06 20.2 In-house 106-288 (302) alignment 
Range on Protein: 113-310
Range on HMM: 106-288/302.0
FFWQMVFEQKSPAIVMLLEDVELGIEKSDKYFPNNTREELKFGIYDITCKEfVKRNILEYRllevsvGNETHQVHHYKFHG--WTEfNLPKYEDFMAfYN
 .| .. . .   .| | . || . .|  .|. .. ..||||| | .. .. || .. |.         .. ...  ...   ... ...|  | .| . 
khwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvs.vktdleeft......dkksfklytveiknekkkk.kvkktvdila.fs

TMKEVGVPLLAVMKNNCMsSFFKKYHhtppTNApIIQCSTGGARCGVFIIIDILINLID-NRIKNsysIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKY
.  . | |  | .  . .  | . |     .|  .. ||.|  | | .. |   |.|   ... .   .   .| ||. |  .  ..||  ..  .. | 
awpdhGapkeaytaldil.kfcesyk....knv.lvhcsaGvGrtGtlvaikyGiqlcskkkvtd...llsivlpvrqcryGavqdeqqliylllcvtkg

I
.
l
0048076 (Phosphotyrosine protein) phosphatases II 176-309 1.5e-07 26.8 In-house 37-142 (145) alignment 
Range on Protein: 176-309
Range on HMM: 37-142/145.0
EVSVGNETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMkevgvpllavmknncmssffkkY----HhtppTNAPIIQCSTGGARCGVFIIIDILINlidn
     ...... .| . .|  .. |   |....|.. .                           .     .  .. || |  | |.........     
tselellerlgiqylylpwpDhgvpdllellleflefi......................eealke....ggpvlVHCsaGvgRtgtlvaaylmll....

rikNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKY
   ...|.|  . .|||.| ..  . .|  |.|. . ..
...lgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 182-304 6.5e-08 28.0 In-house 45-139 (144) alignment 
Range on Protein: 182-304
Range on HMM: 45-139/144.0
ETHQVHHYKFHGWTEFNLPKY-EDFMAFYNTMKEVgvpllavmknncmssffkkyhhTPPTNAPIIQCSTGGARCGVFIIIDILInlidnriKNSYSIEW
.......| . .|  .. | . |.. .|.. ..|.                       .. .  .. || |  | |.........       |. .|.| 
leregiqylhlpwpDhgvpdllellleflefieea......................leeggpvlVHCsaGvgRtgtlvaaylmk.......klglslee

WMLKVRSKRNHSALTNQQHSFIYD
 .  |||.| ..  . .|  |...
alalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 183-313 2.9e-07 24.5 In-house 214-347 (350) alignment 
Range on Protein: 183-313
Range on HMM: 214-347/350.0
THQVHHYKFHGWTEFnlpkyedfmAFYNTMKEVgVPLLAvMKNNCMSSFFKKYHH-TPPTNAPIIQCSTGGARCGVFIIIDILIN------LIDNR----
 . |.. ... | .          .  .  ... .. |  .||. . . | . |  .  ... .. || |  | |... .| |..       . ..    
PyvvyqlqvknWkDl.........slllnPesi.lqale.vkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkl

---IKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTR
    |    |.. ....|..|     . .|. |||. .  | . |
dvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLr
PTPc_DSPc_SM00012 185-307 4.4e-21 70.4 In-house 1-104 (105) alignment 
Range on Protein: 185-307
Range on HMM: 1-104/105.0
QVHHYKFHGWTEFNLPKYEdfmafyntmKEVGVPLLAVMKNNCMSSFfkkyhhtppTNAPIIQCSTGGARCGVFIIIDILINLIDNRIkNSYSIEWWMLK
.|.||...||.....|..          ...   | ||.||.  |.          ..  ...||.|  |.|.|. .|||.. ....  ....|.... .
tvkhyhytgwpdhgvPees.........dsilellravkknknkses.........skpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivke

VRSKRNHSALTNQQHSFIYDIII
.|..|...  |..| .|.|....
lrkqRpgmvqteeqylflyrall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 223-285 6.3e-06 19.8 In-house 246-309 (349) alignment 
Range on Protein: 223-285
Range on HMM: 246-309/349.0
MKNNCMSSFFKKYHH-TPPTNAPIIQCSTGGARCGVFIIIDILINLIDNRIKNSYSIEWWMLKV
.||. . . | . .  |  ... .. ||.|  | ||.. .|.|....    ..|  |. . |. 
vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 243-314 2.1e-09 32.1 In-house 224-294 (298) alignment 
Range on Protein: 243-314
Range on HMM: 224-294/298.0
AP-IIQCSTGGARCGVFIIIDILINLIdnRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYIRTRH
.| |.||| |  | | ||.|| ... .  .....  .   .  .| || ..  |..| .|||....... .  
kpvivqCsaGvgRsGtfiaidsvlerv..kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_CG42327_pd Subfamily CG42327 245-310 9.1e-07 22.8 In-house 251-315 (319) alignment 
Range on Protein: 245-310
Range on HMM: 251-315/319.0
IIQCSTGGARCGVFIIIDILINLIDNRiKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI
.. || |  | |. |  || |. ...  |.|  |   .  ||  | .. || .|. ||| .. .| 
vvhcsdGvGrtGlviasdiairslees.krsvdiPqlvssvrrdrasavltkeqyefiykvlseya