Gene egg-4 in Caenorhabditis elegans

Synonym: CELE_T21E3.1, egg-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily egg
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP052_AA protein Get Run
CeleP052_AA_391-663 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 392-663 6.9e-59 195.4 In-house 13-305 (307) alignment 
Range on Protein: 392-663
Range on HMM: 13-305/307.0
FGAARKAKYLSTIIGGMERRFEILENSVN--HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ-YLGDFIHANRI--------SGKPLFNEFIMT
..   ... | ... |... || | .      ........ .|..|.| . . . |.||. |. . |.   .|.|.|. .        .|  | ..||.|
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSpsdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG--PDREERHVEHWQG----D
|.|...||.|||||.|.. | .|||||. .| .|  |  ||| .     . . | ..... ....  .. . |..|..    .. |.|.| |..     |
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpd

VNNSSNMYSPLNILRLLRN------ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYK-YPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
 . .... . |......|.       ..||..| . ||.|.....|| .... | ...|.. .... ||..||..|| ....| ||.|..........
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_egg_pd Subfamily egg 393-699 6.7e-190 624.3 In-house 1-307 (307) alignment 
Range on Protein: 393-699
Range on HMM: 1-307/307.0
GAARKAKYLSTIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFW
.||.||||||.|....|||.|.||.||..|..|..|||||.||.|..|||||||.|..|...|||||.|||||||..||||.||||..|||.||||||||
eaakkakylseivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfw

RMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNA
|||.||||.||||||||||.|||||||||..||..|||||.|||||..|....|||||||.|.|.|.|.|||..|||||||||||..||||..||.|||.
rmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnl

SKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKELDVDYERWLQERSERMFLDDL
|||||..|.||||.||.|||.|||..||||||..|..|.|||.|||.||..|.|....|.||.|||.|||||||||||||||||||||.||||.||||||
skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyerwleersekmflddl

AAPIPGY
|||||||
aapipgy
0043336 (Phosphotyrosine protein) phosphatases II 400-662 2.1e-56 186.8 In-house 14-277 (278) alignment 
Range on Protein: 400-662
Range on HMM: 14-277/278.0
YLSTIIGGMERRFEILENSVNhIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEE
.| .   .... || | .    ........ .|..|.| . . . |..|. |.   | .  |.|.|. ..| .  ..||.||.|...||.|||||||.. 
lllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

VPYIVMLTSRKEPER--CEYYWPkspsdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN-
|. |||||. .| .|  | .|||       ... |...... ....  .. . |..|..    | |.|.| |..     | .  ... . |..|. .|. 
vttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

---ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
    ..||..| . ||.|.....|...... | ..   ..... ||..||..|| ...||.||.|.........
ledsngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 403-665 1.4e-61 203.8 In-house 10-280 (297) alignment 
Range on Protein: 403-665
Range on HMM: 10-280/297.0
TIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqfprGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
. . .... || | .  . ........ .|.||.| . . . |.||. |    ..   |.|.|. ..|  | ..||.||.|..|||.|||||||.. |. 
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMLTSRKEPER--CEYYWPKSPSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIG-PDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRN----
|||||.  | .|  |. |||    .. .   |...... .|.. ... . ...|..    . |.|.| |..     | .  ....| |....|.|.    
Ivmltelvelgrekcaqywpleegeslty..gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--ASKPVVIHDHLGVSRAACLVAAEIAICSLLRG-PTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDV
   ..||..| . ||.|.....||..... | ..  ......  ||..||..||....|..||.|.......... .
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0051299 (Phosphotyrosine protein) phosphatases II 403-662 2e-61 203.3 In-house 20-286 (288) alignment 
Range on Protein: 403-662
Range on HMM: 20-286/288.0
TIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
. . |... || | .   ........  .|.||.|.. . . |..|. |. . |.  .|.|.|. |.| .| ..||.||.|..|||.|||||||...|..
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

IVMLTSRKEPER--CEYYWPKspsdPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIG---PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNA-
|||||.  | .|  |..|||       ... | .....  ... .|   |. ... ..   .| |.|.| |..     | .  ... . |..|||.|.| 
IvmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

---SKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
   ..|||.| . ||.|.....|...... |...  ..  | .||..||..||....||.||.||........
asgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 405-664 1.5e-59 197.2 In-house 41-301 (308) alignment 
Range on Protein: 405-664
Range on HMM: 41-301/308.0
IGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqfprgQYLGDFIHANRISGK--PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
.|..|. || | .  .........  .|..|.| . . . |..|. |     .   |.|.|. ..|    | ..||.||.|..|||.|||||||...|..
lglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMLTSRKEP--ERCEYYWPKSPSD-PAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDrEERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA--S
|||||.  |   | |. ||| .. . . .   |......  ... .|   |. .|. .| . |.|.| |..     | .  ... . |..|.|.|.   .
IvmLtklvengrekcaqYwplelgggsley..gkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpg

KPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
.|.|.| . ||.|.....|...... | ..  ..  |. ||..||..||....||.||.|..|........
gpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0039614 (Phosphotyrosine protein) phosphatases II 405-663 4.4e-57 189.1 In-house 32-290 (297) alignment 
Range on Protein: 405-663
Range on HMM: 32-290/297.0
IGGMERRFEILENSVNhipFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ-YLGDFIHANRISGKPL-FNEFIMTQAPMKNTVDDFWRMVWQEEVPY
 . ..  .|.|.. ..   ...... .|..|.| . . . |..|. |. ..|.    |.|.|. ..|  |  ..||.||.|...||.|||||||.. |..
tllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtv

IVMLTSRKEPER-CEYYWPKSPSdpavtVPGGLRIENFGVYQapDPLFRVTHLRLIGpDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN------
|||||. .| .| |. ||| . .     . |...... .|..  .. . |..|..   . |.|.| |.|     | .  ... . |..|.|.|.      
ivmLtklvelgrkcaqywpeegg.....tygdftvtllkveh..ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelp

ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
 ..||..| . ||.|.....|| .... | ..  ... |. ||..||..|| ...|| ||.|..........
kggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_ptpA1_pd Subfamily ptpA1 405-542 3.9e-17 57.1 In-house 20-157 (418) alignment 
Range on Protein: 405-542
Range on HMM: 20-157/418.0
IGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKpLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV
|  ..  | .||.||     .      |  | |   .   . ||. |.  . .   |.| || | |    ..|| || |. ||. |||||||.. .  ||
ihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriiv

MLTSRKEPE--RCEYYWPKSPSDPAVTVPGGlRIENFGVY
||.   |    .|. |||.      ... |    | || |
mlsresencrikcdrywpeqiggeqfsiygn.gnevfgty
0040438 (Phosphotyrosine protein) phosphatases II 406-698 5.9e-63 208.4 In-house 18-310 (317) alignment 
Range on Protein: 406-698
Range on HMM: 18-310/317.0
GGMERRFEILENSVNHiPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
..... || | .   . ......  .|..|.|.| . . |..|. |. . | .  |.|.|. ..|  | ..||.||.|..|||.|||||||.. | .|||
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LTSRKEPER--CEYYWPKspsdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA----SK
||. .|..|  |. |||       ... |...... ....  .. . ...|.. .  | |.|.| |..     | .  ... . |..|...|.|    ..
LteleelgrekcaqYwpl....getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpgg

PVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGsaKELDVDYERWLQERSERMFLDDLAA
||..| . ||.|.....||..... | ..   .. |. ||..||..|| ...||.||.|.......... ..   .| . .. ..|... . ..|||   
pvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt..lepaselklkllklliplalddvkl

PIPG
..  
keke
0047943 (Phosphotyrosine protein) phosphatases II 406-662 8e-56 184.8 In-house 12-272 (273) alignment 
Range on Protein: 406-662
Range on HMM: 12-272/273.0
GGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqfprGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
..... || | .  .........  .|..|.|.. . . |..|. |    |.   |.|.|. ..| .| ..||.||.|..|||.|||||||.. |..|||
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LTSRKEPER--CEYYWPKSPSDpAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN------A
||.  | .|  |..||| .  .  ... | ..... ....  .. . |..|.|    . |.|.| |..     | .  ... | |....|.|.       
LtelvelgrekcaqYwplegge.lsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

SKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
..|||.| . ||.|.....|...... | ..  ..  |  ||..||..|| ...|| ||.|.........
ngpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 406-657 2.9e-32 106.6 In-house 19-282 (563) alignment 
Range on Protein: 406-657
Range on HMM: 19-282/563.0
GGMERRFE-ILENSVN-HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLG-DFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
 |... || . ..... ... .||   .|..| |.  .   |..|. |.   |.    |.| || | |    ..||.|| |.|.|.||||||.|...|  
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLTS--RKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPlFRVTHLRLIGPDR--EERHVEHWQgdVNNSSNMYSPLNILRLLRN-------
|||.|    .. . |. ||||  |    ..   |  |.  ....    . . .|.|   ..  .|..| ...    .  .. .|   |  | .       
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrt.lviknlklkkkkqcdteklvrqyh..ytkWPdhgvPehslpvLifvkkssaa

---ASKPVVIHDHLGVSRAACLVAAEiaicSLLRGPTY--KYPVQRAVQFLRQRRPFSIETPMQYIFVHRL
   .  |.|.|.. ||.|.  ... .    .||.      .  | . .. .| .|.| ..|  ||||.|  
nkaeaGPivvHcsaGvgrtGtyivld....tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 406-659 3e-30 100.4 In-house 23-280 (319) alignment 
Range on Protein: 406-659
Range on HMM: 23-280/319.0
GGMERRFEILENSVNHiPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
 ..|. |. |...||   |...  ..|..| | . .   | ||..|.   |.   |.| |. | |    ..|| ||||..||..|||||||.||.  .||
tllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvm

LTSRKEPE--RCEYYWPKSpsdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA-----SK
||  .|.   ... |||.      ... | | ..     .  |   |  .|.    . | |.| |.|     | .   .  | |..|. .|..     |.
ltklveklkvklkkywpee....nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PVVIHDHLGVSRAACLVAAEIAICSLLRGPTYkyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|.|.|   || |    .. ....  . .  .    |   |. ||  |.. ...| ||.|..  . 
PivvhCsaGvGRtGtfivldamlervkeegvl..DvfstvsrlRtqRnimvqrpeqYkfiyeall
subfamily_PTPN23_pd Subfamily PTPN23 406-658 2.3e-22 74.1 In-house 15-276 (288) alignment 
Range on Protein: 406-658
Range on HMM: 15-276/288.0
GGMERRFEILENSVNHIPF--THSASDNNQEKCRNPRVHCKDSTRIALQfprgQYLGDFIHANRISG-KPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
......|. ||.. ..     . ...  . || |.  .   |..|. |.    .   |.| |  . .  |   .||.||||...|. |||.||... .. 
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLTSRKEPER--CEYYWPKSPSDPAVTVPggLRIENFGVYQAPDPLFRVTHLRLIGPDReERHVEHWQGDVNNS-SNMYSPLNILRLLRNASK-----
||||.|..| ..  .. |||..  .. .  .  |..    | ...    || .|.  ..|.  ..| | |     .     || ..|..| .. .     
iVmllskeelgkpkvdrYwPedkgetvkfgd..lsvtlksvretethvervlkletldada.vksvshlqltsWpelGvPasPetllqfldevesayeav

------PVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKyPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
      |.|.|   || |.  .     |.  | .|.     . . |. ||. | |....  |. |.   |
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll.diiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_PTPN9_pd Subfamily PTPN9 407-658 7.6e-34 112.1 In-house 17-286 (297) alignment 
Range on Protein: 407-658
Range on HMM: 17-286/297.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|. . .. . |   .  |..| .  | || |   | | |.||. |.   ..   |.|.|| . |    . || || |.|.||.|||||||..||  ||| 
GlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

TSRKEPER--CEYYWPKSPSDpaVTVPGGLRIENFGVYQAPDPLFRVTHLRLIgPDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA--------
|   |  |  |  |||..  .  ..  | |...|  | .  |  .|| ... .  ..|.|.| |.|     |    |.  | |..|.  |..        
trvvergrlkcgqyWpleees..saefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

---------SKPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
           |.|.|   |. |.  ... .|..  | .  . .  |. .|. ||..| ||| || || | .  |
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Ptp69D_pd Subfamily Ptp69D 407-659 1.8e-32 107.7 In-house 23-283 (307) alignment 
Range on Protein: 407-659
Range on HMM: 23-283/307.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|... .| ||..  .   . |. ..|. | | . ..  |.||. |.   |.   |.| |. | |   ...||. |.|. .|..|||||... ||  ||||
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TSRKEPER--CEYYWPKSpsdpAVTVPGGLRIENFGVYQAPDP---LFRVTHLRLIGPDREER------HVEHWQgDVNNSSNMYSPLNILRLL----RN
.  .| .|  |. |||.       .  | . ..     ...|     . |..    ... |..      |   |. |..      . |.... .    ..
snlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
   |.|.|  .||.|.. .|| .. .  |      |  .   |. ||..|.. ..   ||.|..| ..
nrsPivvhCsaGvgrsgifvaldsllqqlkae..dkvdifetvkdLrsqRnllvqsleqYvflyrall
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 407-659 5.7e-30 99.3 In-house 22-276 (288) alignment 
Range on Protein: 407-659
Range on HMM: 22-276/288.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|... .. | .  ..   | .   .|..| | . .   | .|. |.    .   |.| |. | |.   ...| ||.|. .||.|||..|.....  ||||
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

TSR--KEPERCEYYWPKSPSDpavTVPGGLRIENFGVYQAPDPLFRVTHLRligPDREERHVEHWQ------GDVN-NSSNMYSPLNILRLLRNAS-KPV
|.   .. ..|| |||..      .  | . ..  .. .  | . |   |     . .|... ..|       .|  .. ..   |...    .|  .|.
telveggktkCeeYWPdadkp...knyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

VIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..|   || |.   .|.. .|  . .  . .  |  .|. ||..|.. ..|  ||.|... ..
ivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 407-658 4.6e-29 96.4 In-house 16-272 (281) alignment 
Range on Protein: 407-658
Range on HMM: 16-272/281.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|. . .| |..  .. . | | .|.|..| |   .   | ||. ..    .   |.| || ..|    .|.| ||.|. .....||.|||...|  |||.
GfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

TSRKEPE--RCEYYWPKSPSdpaVTVPGGLRIENFGVYQAPDplFRVTHLRLIGPDREERHVEH-----W--QGDVNNSSNMYSPLNIL-RLLR-NASKP
|   | .  .|  |||   |    .  | .....    . .   .   ...|   . |.|.||.     |  .|  ...... .  . . .| . .   |
treieagklkChrYWPddns...elkygdvtvkstaeeekat..yierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

VVIHDHLGVSRAACLVAAEIAICSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
.|||   || |. . .| . .. .. .  . .  |.  |. ||..| . . | .|| ||.. |
lvihCsaGvGrtGtyialDrlvkaveae.leeldvkavvaelrkernlmvqtvvqyefvykav
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 407-658 5e-29 96.4 In-house 23-279 (305) alignment 
Range on Protein: 407-658
Range on HMM: 23-279/305.0
GMERRFEILENSvnHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|.| ... | .   . ..    ...|..| |.  .   |  || |.    .   |.| |. . |    ...|..|.|.||||.||||....| |  ||||
gleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivml

T--SRKEPERCEYYWPKSPSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHW-------QGDVNNSSNMYSPLNILRLLRNAS--KP
|     . ..|. |||.| ...     | . .|     .|.| . |  ..     |.|.| | ..       .| .. .. . | .. ..  .. .  .|
tklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

VVIHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
...|   ||.|.   .| .||.  | .  .    | . .. ||..|.  ..|  || |.|  .
llVhCsagvgRtGvfiavdialerlkkEev..vdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_PTPN6_pd Subfamily PTPN6 407-663 5.1e-28 92.9 In-house 27-298 (306) alignment 
Range on Protein: 407-663
Range on HMM: 27-298/306.0
GMERRFEILENSVNHIPFT--HSASDNNQEKCRNPRVHCKDSTRIALQfPRGQYLGDFIHANRISGK--PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
|.|  || |... ..  ..  ..|  .|.|| |   .   | ||. |.   . .  |.| || |...     ...| ||  ...|| |||||||||.   
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTSRKEP--ERCEYYWPKSPSDPAvtvPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN-----
|||.|   |   |.|  |||.. ....    | ....|    .. |  .|  ..  .  ..|||.| ...     | .  .. .  |. |. ...     
ivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

---ASKPVVIHDHLGVSRAACLVAAEIAICSL-LRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
    . |.|.|   |. |   ..  .| .  .  .|  ... .|..|. .|. |   . |  || ||.. .... .
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 407-659 4.1e-27 89.8 In-house 21-280 (290) alignment 
Range on Protein: 407-659
Range on HMM: 21-280/290.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ--YLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV
|.. .|. |... ..   |.  . .|... |  ..  .|  || |.   |.     ..|.|  | |    ...|.||.|..||. |||...|||.|. ||
gfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiiv

MLTSRKEPE--RCEYYWPKSPSDPavTVPGGLRIENFGVYQapDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSN-MYSPLNILRLLR--------NAS
|||. .| .  .|  |||.|...     .  ... |  ...  .   |  ...    . ....| ..|    .|   .  |  || ...        .  
mltniieegkvkCqqYWpdsdtka..ygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

KPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
...|.|   .|.|.| ..||...|       .    |   .. .|. .| |..|  || .....| 
tsivvHCSdtvgrsavfcaaattinkckt..egvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 407-659 2.2e-26 87.5 In-house 21-275 (287) alignment 
Range on Protein: 407-659
Range on HMM: 21-275/287.0
GMERRFEILEN-SVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQfprgQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
| . .| .||. . ..   ||. . .|..| |  ..  .|  |. |.    .   |.| |  | |    ..||....|| ||. .||.......|. |||
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivm

LTSRKEP--ERCEYYWPKSPSdpavTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSN-MYSPLNILR----LLRNAS----K
|.  ||   | |  |||.. |    .| |  .||     .  . . |  ...  . . ....|. .|    .|   . .|  ||       ..       
lcqekendeevcyqyWpeeks....vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt

PVVIHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..|.|   .| |.| ..||...|    .  .    | . ..  |...| |. |  ||.|.  .| 
sivvhCsdtvGrsamfcaaattinkckteGv..iDvfqvlksqriqkpgsvqtveqykfindivl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 407-525 3.4e-19 63.6 In-house 16-137 (301) alignment 
Range on Protein: 407-525
Range on HMM: 16-137/301.0
GMERRFEILENSvNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRG--QYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV
..| ... |..  .. . | . |..|..  |.  .   |  || |.  .   .   ..| |. |.|    ..||..|.|||.|. ||||..||| .  ||
kfeeqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTSRKEP--ERCEYYWPKSPSD
|.| .||   ..|| |||.|  .
mvtnlkegtkskceqywpnseae
0046845 (Phosphotyrosine protein) phosphatases II 408-664 2.3e-58 193.2 In-house 2-276 (284) alignment 
Range on Protein: 408-664
Range on HMM: 2-276/284.0
MERRFEILENSVNHI--PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ-YLGDFIHANRISGK-----PLFNEFIMTQAPMKNTVDDFWRMVWQEE
.|. || | . . ..  ......  .|..|.| . . . |..|. |. . |.   .|.|.|. ..|         ..||.||.|..|||.|||||||...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VPYIVMLTSRKEPE--RCEYYWPKSpSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNA-
|..|||||.  | .   |..||| . ... .   |......  ... .|   |.  |. .|.. |.|.| |..     | .  ... . |..|||.|.. 
vrvIVmltelvengrekcaqYwple.gevlty..gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----SKPVVIHDHLGVSRAACLVAAEIAICSLLRGP-TYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
     ..|.|.|.. ||.|.....|...... | ..  .....|. ||..||..||....|..||.||......... 
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPRD_pd Subfamily PTPRD 408-659 5.4e-38 126.0 In-house 25-278 (564) alignment 
Range on Protein: 408-659
Range on HMM: 25-278/564.0
MERRFEILENSvNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLT
.|.... .|.. .. ...... . |..| |   .   |..|. |.  .|.   |.| |. | |    ...| ||.|...|..|||||||....  |||||
feeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

SRKEPER--CEYYWPKSpSdpAVTVpGGLRIENFGVYQAPDPLFRVTHLrLIGPDREERHVEHWQGDV-NNSSNMYSPLNILRLLRN-------ASKPVV
. .| ..  |. |||.. .    |. |.| ..    ..  |  .|   |     ..| | |....     ..  . |. ..|.|.|.        ..|.|
kleEkgkvkchkYWPek.g..tety.geltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPiv

IHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
.|   || |  . .. .. .  .      .  .   |. ||. |.. ..|. ||||.|. ..
VhCSaGVGRTGtfividamlerike..ektvDiyqyvkalrkqRnamVqteeQYiFiheail
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 408-659 9.2e-33 108.6 In-house 22-277 (318) alignment 
Range on Protein: 408-659
Range on HMM: 22-277/318.0
MERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLT
... .| |. | ...  ..| .. |. | |   .   |.||..||   |.   |.| || | |    ...| .|||. .|..|||||||. .   |||||
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

SRKEP--ERCEYYWPKSPSdpavTVPGGLRIENFGVYQAPDPLFRVTHLRLiGPDREERHVEHWQG-DVNNSSNMYSPLNILRLLRNAS--------KPV
  .|   .... |||.. |    .  | |..|     .  | . |  ...      |.|.|  ..  .  ...   |. ..| |.|..|        .|.
qeeergkakvhryWPskgs....rsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

VIHDHLGVSRAACLVAAEIAICSLLRGPTYkyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|.|   || |.   .| .| .  .    .    |   |. ||..|.  . |  ||.|..  . 
vvhCsaGvGrtGvfiavdillerikaealv..Dvfqtvkqlreqrnlmvqtedqyefiydvll
DSPc_SM00195 409-662 5.1e-53 175.4 In-house 3-262 (263) alignment 
Range on Protein: 409-662
Range on HMM: 3-262/263.0
ERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS
.. || ||.| .. ..|... ..|..| |   . . |.||. |. . ..   |.|.|| |.|.   ...|.||.|...||.|||||||.|.|..|||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

RKE--PERCEYYWPKSPSDPAVTVpgGLRIENFGVYQAPdPLFRVTHLRLIGPD-REERHVEHWQGDVNNSS----NMYSPLNILRLLRNA----SKPVV
 .|   |.|. |||..  .. .     .....  | . .   . ...|.|   . .|.| |...|    . .    .. | |..|| ...     |.|.|
eeengkekcdrywpeesggketfg..kisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

IHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
.| . ||.|....|...|.. .| .. .  . ..  |. ||. || ...| .||.|... .....
VhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 409-662 5.1e-53 175.4 In-house 3-262 (263) alignment 
Range on Protein: 409-662
Range on HMM: 3-262/263.0
ERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS
.. || ||.| .. ..|... ..|..| |   . . |.||. |. . ..   |.|.|| |.|.   ...|.||.|...||.|||||||.|.|..|||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

RKE--PERCEYYWPKSPSDPAVTVpgGLRIENFGVYQAPdPLFRVTHLRLIGPD-REERHVEHWQGDVNNSS----NMYSPLNILRLLRNA----SKPVV
 .|   |.|. |||..  .. .     .....  | . .   . ...|.|   . .|.| |...|    . .    .. | |..|| ...     |.|.|
eeengkekcdrywpeesggketfg..kisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

IHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
.| . ||.|....|...|.. .| .. .  . ..  |. ||. || ...| .||.|... .....
VhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 409-661 8.7e-15 49.4 In-house 9-258 (267) alignment 
Range on Protein: 409-661
Range on HMM: 9-258/267.0
ERRFEILENSV-NHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQylgdFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLT
|. || ...   ..   . | . .|||. |   .   | ||. |.    .    .| |  . |    | ||.|| |.|||. ||. .. ...|| ||.||
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

SRKEPERCEYYWPK---SPSDPAVTVPGGLRIENFgVYQAPDPLFRvtHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILR--LLRNASKPVVIHDHL
   . .   .. ||   .     .||   |  |.   ||     ..         .    . ..|. ..||   .   . ||    | |...|.|..   
kvftdnirlfwPPkmgqakkyqdltvehslekeen.dyqiitlelk..fknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsd

GVSRAACLVAAEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFF
|| |.  .. ..  .  . .  . .  .   .. .|..|.  ..|  .||..|.|.| .
GvGrsGtflvidsqleraktegvsd..ifdflrkirsqriglvdtkeryiyihellaey
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 410-659 1.5e-29 98.2 In-house 31-287 (298) alignment 
Range on Protein: 410-659
Range on HMM: 31-287/298.0
RRFEILENSVN---HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
  |. |..  .   .   . . ...|..| | . .   ||.|. |.   ..  .|.| |  ...    | ||.||||...|| ||||||..|..  ||||
lefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVml

TSRKEPER--CEYYWPKSP--SDPAVTVpGGLRIENFGVYQAPDplFRVTHLRLIgPDREERHVEHWQ-GDVNNSSNMYSPLNILRLLRN---AS--KPV
|. .| ..  .. |||..       .||   |. |.|. .      . |.. .     || |.... .  |   ..|. | |..||  |     .  |||
tnleeldktkyhkywPdegketygeitv.sllskeefadlivrk..lkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpv

VIHDHLGVSRAACLvaaeIAICSLLRGPT--YKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
...   || |.       ||| |.|       .  | ..|. ||..|| ...|  ||.|.. .| 
ivqCsaGvgRsGtf....iaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 410-660 1.5e-21 71.9 In-house 27-286 (325) alignment 
Range on Protein: 410-660
Range on HMM: 27-286/325.0
RRFEILeNSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMV--WQeeVPYIVMLT
. |..|  |.. | .. ..  .|..| | . |   | .|. |.  . .   |.| |. .      . |. .|||. .|..|.||.|  |.   . .|.| 
hefgll.psddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvvln

SR-KEPERCEYYWPKSPSDpAVTVpGGLRIENFGVYQAPDPLFRVTHLRLIGPD----REERHVEHWQ--GDVNNSSNMYSPLNILRL----LR---NAS
   .. .||  ||||  .. ..|  |||...   . .  | . || ... .        .. ..  |.  |  .  . . | |...      ..   .||
eldlgkdrcavywpkemgk.sktf.GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

KPVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF
 |...|   || |.  ...   |.  ..     .  .   |. ||. ||  .||  |||...  .. 
tpilvhcsaGvGrtGvfislysalakviees..rvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_PTPRB_pd Subfamily PTPRB 411-662 1.7e-32 107.6 In-house 30-285 (293) alignment 
Range on Protein: 411-662
Range on HMM: 30-285/293.0
RFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK
..| |..  ..   . . .  |..| |  ..   | .|. |.  ...   |.| || |.|    .||| || |. .||||||||||....  |||||   
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlv

EPE--RCEYYWPKSpsdPAVTVPGGLRIENFGVYQAPDplFRVTHLRLIGpDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNAS------KPVVI
|    .|| |||.       .. | ....     .  |  . . .|..   ..|||.|....     | .  ..  . |...| .|.|       .|.|.
ekgkvkCeeYWPad...eepvlyGdikvtlvaeeeled..wvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
|   || |.  ..| .  . .. .  .    .   |. ||..| . . |  ||||.|. |  ..
hCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN3_pd Subfamily PTPN3 411-658 6.6e-27 89.1 In-house 20-271 (280) alignment 
Range on Protein: 411-658
Range on HMM: 20-271/280.0
RFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK
.|| |    . .  ...   .| .| |   .   |.||. |.  .  |.        | .. | | .| || |...|. |||.|||....  |||||.  
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlv

EPE--RCEYYWPKsPSDpaVTVPGGLRIENFGVYQAPDPLFRvtHLRLIGPD-REERHVEHWQ------GDV-NNSSNMYSPLNILRLLR-NASKPVVIH
|    .|  |||. ..|   .  |.....     .    ..|  .| |   . .|||.. . |       .| ..|... . .. .| ||  ...|||.|
erGrvkChqyWPe.ted..eleygefsvkcekedetksyvlr..elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

DHLGVSRAACLVAAEIAICsLLRGPTYKYPVQrAVQFLRQRRPFSIETPMQYIFVHRLV
   |. |.  |.. |.|.. |.      ||..  |. .|..|   ..|. || ||   .
CsaGigrtGvlilletala.lieaaepvypld.ivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 411-662 1.2e-22 75.0 In-house 15-277 (287) alignment 
Range on Protein: 411-662
Range on HMM: 15-277/287.0
RFEILENSVNHIPFTHSASDN--NQEKCRNPRVHCKDSTRIALQfPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS
 .. | .  .  ..|  |...  . .| |   |   | ||. |    |..  |.| || ...    ..|| .|.|.  || ||||.|.....  ....| 
evdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

RKEPERCE--YYWPKSpSDPAVtVpGGLRIENFGvYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPL---------NI---LRLLRNAS-
  |  | .   |||.    |   | ||  .  .  |.  .| . |  ||||  . .| .| .    ..  ..  .|          ..   . | |.|| 
eveearlkcykywPer.evPmr.v.GGysvvlld.ydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase

-KPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
  |.|.||  |. |.  |.|  . .  |.   . .  | ..| .||..|   . ...|. ..   .. ..
vGPlvvhddvGiGrsGillatlvlvsrled..lGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 413-663 6.2e-30 99.2 In-house 5-269 (274) alignment 
Range on Protein: 413-663
Range on HMM: 5-269/274.0
EILENSVNHIPFTHSASD----NNQEKCRNPRVHCKDSTRIALQFPRGQY-LGDFIHANRISGKPL-FNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
. ||.   ..|  ..  .     .|.| |   .   . .|. |.   ..  . ..| || | |     . .. || |. |||.|||||..||||. ||||
kdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TSRKEPER--CEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDplFRVTHLRLIGPDReERHVEH-WQGDVNNSSNMYSPLNILRLLRN---------AS-
|  || ..  |. |.|.. .       |.. |.. .. .  |  ..|..| |    | ||.| | |  |  .     .. ..|.|...         |  
tklkeaneqkCavyfPdaedyeiserygdveikvekivernd..ysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenakl

KPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
 |||.|   |. |. | .|..||.  | .  . .  | . |  ||. |   ..|  || ..|| .. . .
apvvvhCsaGiGrtGcfiaisiavrqlre..eivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN14_pd Subfamily PTPN14 413-527 8.9e-17 56.0 In-house 30-147 (300) alignment 
Range on Protein: 413-527
Range on HMM: 30-147/300.0
EILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQyLGDFIHANRISGK--PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK
| . .  ..  .. .. ..|.|| | . |   . .|. |.  . .   ..| | .|.        ..|..|.|...|| |||.|||...|  |||||. .
eripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

EP--ERCEYYWPKSPSDPA
|   |..  |.||. |   
edgkeksfkyfPkleskkk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 416-691 4.7e-26 86.8 In-house 45-318 (319) alignment 
Range on Protein: 416-691
Range on HMM: 45-318/319.0
ENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTsrkePERC
. .||    |..  |.|..| |  ..   | ... |.   |.   |.| |  ..|    . .| .| |..||..|||||.|. ..  ||.||     ..|
klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt....kdkc

EYYWPKSpsdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVE--HWQ-----GDVNNSSNMYSPLNILRLL---RNASKPVVIHDHLGVS
  |||.     .|   .   ..   | .. .   |  .|   |  .. |..   |..     |  . .|..   .. .| |    |  ...|.|   || 
sqywplk....ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RAACLVAAEIAIcSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHrlVAFFFRDVIGSAKELDVDYERWLQERSERMFLDD
|.   .. .. . . ..    .  | . |. |||.|.  ..  .|| |..  .|.    ..| .     |.  .|.|.|..  .||
rtGvyivldvll.drmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiy..salleehlfghsdvampdfpayleelsnksdfdd
subfamily_PTPN1_pd Subfamily PTPN1 416-653 7.3e-20 65.8 In-house 16-262 (290) alignment 
Range on Protein: 416-653
Range on HMM: 16-262/290.0
ENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQfpRGQYlgDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS--RKEPE
..  ...| ...  ..|... |   |.  | .|| |.  |..   |.| |. .  . .  ..|.|| |. |||| ||.|||...   .|||     ||  
rkeasdfptreaklpenrnlnryrdvspydhsrikle..radn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

RCEYYWPKSPSDPAVTVP-GGLRIENfgVYQAPDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNA------SKPVVIHDH
.|  |||.  .. ....    |...   . .     ..| .|.|     .| |.. |.      |    .   . |. |  .|..        |.|||  
kcaqywPqgeeekellledtklkvkl..iseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

LGVSRAACLVAAEIAICSLLRGP-TYKYPVQRAVQFLRQRRPFSIETPMQYIF
 |. |.  .. ..  .  . .   .    ... .  ||. |   | |. |  |
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 416-506 6.7e-06 19.8 In-house 18-107 (332) alignment 
Range on Protein: 416-506
Range on HMM: 18-107/332.0
ENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQylGDFIHANRISGKPLFNEFIMTQAPMKNTVD-DFWRMVWQEEVPYIVML
  |    | |.    || .  | |...| | .|. |    |.   ||  |. . |    . .|..|||...  .  ||||| . .   |...
htsamtypntydkflnnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
0045098 (Phosphotyrosine protein) phosphatases II 417-662 2.6e-49 163.5 In-house 18-272 (278) alignment 
Range on Protein: 417-662
Range on HMM: 18-272/278.0
NSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIAlqfprgqylgDFIHANRISGKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--R
   .   .|..   .|..|.| . . . |..|.           |.|.|. |.| |  ..||.||.|...||.|||||.|.. ...|||||. .| .   
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgyp..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CEYYWPKspsdPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLI---GPDREERHVEHWQG-DVNNSSNMYSP-----LNILRLLRN--------------
|. |||       . . |....... ... .|   |. ... .    .| |.|.|.|..   .   .   .|     |..|. .|.              
caqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---ASKPVVIHDHLGVSRAACLVAAEIAICSLlrgpTYKYPVQRAVQFLRQRRPF-SIETPMQYIFVHRLVAFFF
    ..||..| . ||.|...|||| . .. |      .. .. ||..||..||. ......||.|...... ..
lldsggpvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 417-691 2.8e-26 87.7 In-house 10-283 (284) alignment 
Range on Protein: 417-691
Range on HMM: 10-283/284.0
NSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTsrkePERCE
 .||    |..  |.|..| |  ..   | ... |.   |.   |.| |  |.|    . .| || |..||..|||||.|. ..  ||.||     ..| 
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kdkcs

YYWPKSpsdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVE--HWQ-----GDVNNSSNMYSPLNILRLL---RNASKPVVIHDHLGVSR
 |||.     .|   .  ...   | .. .   |  .|   |  .. |..   |..     |  . .|..   .. .| |    |  ...|.|   || |
qywplk....ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

AACLVAAEIAIcSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHrlVAFFFRDVIGSAKELDVDYERWLQERSERM-FLDD
.   .. .. . . ..    .  | . |. |||.|.  ..  .|| |..  .|.    ..| .     |.  .|.|.|... | ||
tgvyivldvll.drmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiy..salleehlfghsdvalpdfpayleelsnksdfddd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 417-658 1.6e-23 78.0 In-house 18-262 (283) alignment 
Range on Protein: 417-658
Range on HMM: 18-262/283.0
NSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLG-DFIHANRISGKplFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--
 || . . . ...|.|..| ||  .  .|  |. |.    .|.   ||  ..   .   ...|..|.|...|| |||.||..|..  |||||  .| .  
lsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykq..dkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

RCEYYWPKSPSDPAVTVPGGLRIENfgvyQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNIL----RLL----RNASKPVVIHDHLGVS
.|  ||||  |         || |            .   ||  .  ...  . |.| .   . .  ...| |    ..     ..   |.|.|   |. 
kCsqyWPkrGsedyGeftvtlrket....tsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiG

RAACLVAAEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFVHRLV
|.| ..||  ..  .|        |   |. .|..|.  . |  || .|| ||
rtavfiaasasvkdaltesvvd..vfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 418-654 1.4e-20 68.2 In-house 36-273 (301) alignment 
Range on Protein: 418-654
Range on HMM: 36-273/301.0
SVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqFPRGQYLGdfIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERC
....   |.| .  ...| | | | || || . . .  |. .   |||| |. .   . || ||.|.||| .||| |. | .|  ||||. . |   |.|
tidkdhitesyaylpkdkhryptvPckPstavev.ivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

EYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNS----SNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLV
|.| | ..|.        ..|.|  .    .   |  ...    . . | | |.|                 ... |.... ||.|.|   |. |. ...
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafi

AAEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFV
..|.    ..  || .  ...|.. ||..|  .. |  |  ..
gteylareveadptie..ltealkhlrehrwngvqtnsqlywm
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 420-658 7e-23 75.5 In-house 31-272 (515) alignment 
Range on Protein: 420-658
Range on HMM: 31-272/515.0
NHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEY
|  | | .  . | .| |   .   ||.|. |.    .   |.. |  | .    . .| .|.| | .||||||.|.||.|  |.|.| .|| .  .|  
niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgk

YWPKSPSDpAVTVpGGLRIENFGVYQAPDPLFRvtHLRLIGPDReERHVE-----HWQgDVNNSSNMYSPLNILRLLRN----ASKPVVIHDHLGVSRAA
|||. |.| .|   | ...|   .    . . |  .|...  |   | |       |  |     .  | | ... ..      . |..||   || |. 
yWPdkpgd.svkf.Gsikvelvsleactggikr..kltvlkgdd.srtvtqfhfteWP.dkGvpkhtssllklikevkadhgqythpliihcsaGvGrtG

CLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
 .....  .       |    | . |. .||.||. . |  || |..  |
vvisidsvvahakt..trmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 422-540 1.5e-19 64.7 In-house 42-158 (310) alignment 
Range on Protein: 422-540
Range on HMM: 42-158/310.0
IPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYlGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYW
  .|. |  ..  | |   | |.|..|. |.  . .| .|.|||| .  . | . || .| |.. |. |||||..||    |..|    |    .|  ||
ssltyeaykkymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PkspSDPAVTVPGGLRIENFG
|   |       | .|. |..
p...slgvtetygcirvtnls
0040439 (Phosphotyrosine protein) phosphatases II 423-662 1.7e-54 180.4 In-house 2-246 (249) alignment 
Range on Protein: 423-662
Range on HMM: 2-246/249.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWP
.....   .|..|.|.| . . |..|. |.  .| .|.|.|.|. |.|    ..||.||.|...||.|||||.|.. . .|||||| .|.  | |. |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

KspsdPAVTVPGGLRIENFGVYQAPDplFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN------ASKPVVIHDHLGVSRAAC
       ... |....... |.. .|  . |..|.|    | |.|.| |.|     | . .... . |......|.       ..||..| . ||.|...
l....ggsleygdftvtllsvevkdd..ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
..|| .... | .   ...... ||..||..|| ....| ||.|.........
fiaaylmleqleke..lgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 423-671 5.5e-28 92.7 In-house 31-286 (290) alignment 
Range on Protein: 423-671
Range on HMM: 31-286/290.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWP
. ... ...|..| |   .   | .|. |.  ...   |.| || | |     |.| .|.|. .|.||||||.|. .|  .||.    | .  .|| |||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

KSPSDPAVTvpGGLRIENFGVYQAP-DPLFRVTHLRLIGPDRE--ERHVEHWqGDVNNSSNMYSPLNILRLLRNA----SKPVVIHDHLGVSRAACLVAA
..  ..  .  | .....    .   | | |  ...  .  |.    | ..|  | .  |.. | |....|.|.     ..|.|.|   || |.  ..| 
eegeeelef..gefevtleeekavdddflirtLkveaqkesrkvyqfhYtaW.PDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

EIAICSLLRGPT-YKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKE
...   | .. .  .. |   |. ||..|.  . |  || .|.. || ...  ... .|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 423-655 1.2e-27 91.3 In-house 45-276 (290) alignment 
Range on Protein: 423-655
Range on HMM: 45-276/290.0
PFTHSASDNNQ--EKCRNPRVHCKDSTRIALQfprGQYLGDFIHANRISGkpLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYY
..  .  |.|   .| |   | | | ||. |.     | ||..||| . |  |   ||.|| ..|.|| |.|||| ||.| .||||    |    .|| |
ylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPKSPSDpAVTVpGGLRIEnFGVYQAPDPLFRVTHLRLIGPDREERH------VEHWQGDVNNSSNMySPLNILRLLRNASKPVVIHDHLGVSRAACLVA
.|.   . ..|  | . .      . .|       | .   |    |      .  |       |.. . | .|| ||.|| |||.|   |. |.  .||
ypekeGe.vltf.Geitvl.cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl.allrtlrilrkasGpvvvhcsaGiGrtGtfva

AEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFVH
 |...  || |  ..  .   |. ||. |  |..  .||. . 
ievglqilldGkeld..lldlvralrnsrlnsvqvdiqylalv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 423-521 1.8e-18 61.6 In-house 40-140 (315) alignment 
Range on Protein: 423-521
Range on HMM: 40-140/315.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS--RKEPERCEYYWP
|.  .   .|..| |   .   | .|. | .   .   |.. || | |    . .| .|.|  ..|.||||.|..|..  |||||.   .| ...| |||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

K
 
d
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 423-658 4.7e-17 56.5 In-house 36-232 (392) alignment 
Range on Protein: 423-658
Range on HMM: 36-232/392.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPErceyywpks
| | .  . |..| |   .   ||.|. |.        |.. |  | .    . .| .|.|   ..|||||||.||.|  |.|.|  || .         
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

psdpavtvpgglrienfgvyqapdplfrvthlrlIGPDRE---ERHVEHWQGDV--NNSSNMYSPLN-ILRLLRNASKPVVIHDHLGVSRAACLVAAEIA
                                   | |       |.  |  .   . .|..   .. .     . ..|..||   || |.. ... .  
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsv

ICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
..   .  |    |   |  .|..||. ..|  || |..  |
vahakk..trmvdvfnfvtnirrkrpymvqtkeqyafiygav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 423-521 3.5e-10 33.8 In-house 59-155 (349) alignment 
Range on Protein: 423-521
Range on HMM: 59-155/349.0
PFTHSASDNnqEKCRNPRVHCKDSTRIALqfprGQYLGDFIHANRISGKPLFN--EFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYY
|. ||      .|  ..    | ||  .     .  | |.| || ..   .     .| ||||.  |||||....  ..|. .. |.. ||.  |.|. |
Pyehsrvkl..kkslksskvikastsesd....sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiy

WPK
| .
wqe
0037934 (Phosphotyrosine protein) phosphatases II 424-661 4.5e-44 146.2 In-house 2-241 (243) alignment 
Range on Protein: 424-661
Range on HMM: 2-241/243.0
FTHSASDNNQEKCRNPRVHCKDSTRIALqfpRGqylGDFIHANRISGKPlfnEFIMTQAPMKNTVDD----FWRMVWQEEVPYIVMLTSRK--EPERCEY
|... . .|..|.| . . . | .|. |    |   .|.|.|| | . |    .| ||.|...||.|    ||||.|.. . .|||||. .  . | |. 
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPkspsDPAvtVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNS----SNMYSPLNILRLLR------------NASKPVVIHDH
|||    ..   . |...... .... .|   |. .|. ...| ..|.| |..          ... . |..|. .|            . ..||..| .
ywp....gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

LGVSRAACLVAAEIAICSLlrgptyKYPVQRAVQFLRQRRPF-SIETPMQYIFVHRLVAFF
 ||.|...|.|| . .  |      ..... ||..||..||. ...|| ||.|........
aGvgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 424-664 8.3e-33 108.7 In-house 33-279 (307) alignment 
Range on Protein: 424-664
Range on HMM: 33-279/307.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRgqYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPK
 |  | . |..| |   |.|.| .|| ..|.      |.|||| .      . || .| |..||. .|| |. ||.|  ..||    |    .|| ||| 
vtveafsantdknryqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl

SPSDPAVT--VPGGLRIENFGVYQ-APDP-LFRVTHLRLIGPdREERHVEHWQGD-----VNNSSNMySPLNILRLLRNASKPVVIHDHLGVSRAACLVA
   .  |    |  . ..|.|. . |||  |  || |..    .. | ..|.| .          |. . .|.|   |    |||.|   || |.  .||
eegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinl.tainlleavrydtnpvvvhcsaGvGrsGtiva

AEIAICSLLRGPTYKyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
  .    ...|   |  ... |. ||..|...|.| .||...||..  .| .
islvqdkmiaGinck.dmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_PTPRA_pd Subfamily PTPRA 424-682 1.2e-27 91.7 In-house 50-313 (330) alignment 
Range on Protein: 424-682
Range on HMM: 50-313/330.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPK
.  .. ..|.|| | ...   | .|. |.  .|.   |.| |  | |    ..|| .| | ..||.|||||.|. .   |||||  ||   |.|. |||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

SPS----DPAVTVP-----GGLRIENFGVYQAPDPLfRVTHLRLIgpdrEERHVEHWQgDVNNSSNMYSPLNILRLLR----NASKPVVIHDHLGVSRAA
  .    .  |.|        . . .| | | ||   |  . ||.    .  | . |  ||   ..    |..|. ..    . . |.|.|   || |. 
eGlvtyGnirvevedetvlvdytvrkflvqqlpdat.rekksrlv....rqfhftswP.dvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

CLVAAEiAICSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFrdVIGsAKELDVDY-ERWLQE
 ... . |.   ..    |  | ..|. ||..||  . | .|| |... .  ..  . |   ||||   |. ||.
tfivld.avlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy..lyg.dteldvsslekhlqk
subfamily_PTPRK_pd Subfamily PTPRK 424-657 1.6e-26 87.9 In-house 35-272 (314) alignment 
Range on Protein: 424-657
Range on HMM: 35-272/314.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPK
.  .  |.|.|| |   .   | .|. |.   |.   |.| |. | .    ..||.|| |...|| ||||.|..|.   |||||  .|    .|  |||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

SpsdpAVTvPGGLRIENFGVYQAPDPLFRVTHLRL-IGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNAS----KPVVIHDHLGVSRAACLVA
     . .  | ...|   .    . . |.  ..    .  | | | ..|     | .   .  . |...| . . .     ..|.|   |  |. . .|
d....tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

AEIaICSLLRGPTyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRL
 .| .. ...       |  ||. ||.|..  .||  ||.|..  
idi.vldmiereg.vvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 424-659 2.4e-25 84.3 In-house 43-281 (297) alignment 
Range on Protein: 424-659
Range on HMM: 43-281/297.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLfnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE-PERCEYYWPKS
 | .    | || |   .   || |. |.    .   |.. |  . |     ..| || |||.||.|||.||..|.|  ||||.  .|  ..|  ||...
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

psdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPdREERHVE-----HWQ-GDVNNSSNMYSPLNILRLLR-----NASKPVVIHDHLGVSRAACLV
    .||  | . ..   | .    . |  ...   . . .| |.     .|   .|..  .. | |...  .|     ||. |...|   || |.. |.
....gvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

AAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
. .  ..   |  . .  .   |. ||| ||. . |  || ||. .| 
tidsvvaeakr..ekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 424-519 4e-08 27.1 In-house 29-129 (347) alignment 
Range on Protein: 424-519
Range on HMM: 29-129/347.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQfP------RGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEY
|| .  ... .| |   |. .|.||. |  |      | .    .| |  |      .|.|.|| |. .|| |||.||    |  .| .   .. |  | 
ftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee

YW
. 
fa
0042113 (Phosphotyrosine protein) phosphatases II 425-662 1.5e-50 167.3 In-house 2-243 (245) alignment 
Range on Protein: 425-662
Range on HMM: 2-243/245.0
THSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKs
....  .|..|.|.. . . |.||. |. . |..  |.|.|. ..|    . ||.||.|...||.|||||.|.. . .|||||.  | .|  |. |||  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

psdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN-----ASKPVVIHDHLGVSRAACLVA
     ... |...... ....  .. . |..|..   .| |.|.| |..     | .  ... . |..|...|.     ...||..| . ||.|.....|
...gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

AEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
| .... | .   ...... ||..||..|| ...|| ||.|.........
aylmleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 425-521 1.7e-12 41.9 In-house 28-123 (285) alignment 
Range on Protein: 425-521
Range on HMM: 28-123/285.0
THSASDNNQEKCRNPRVHCKDSTRIALQfprgQYLGDFIHAN--RISGKPLfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWP
|..| . | .  |   |.| . ||. |.    ..  |.|||.  |. ||   . .| || |. .|. |||.|..||.. |..|| .  |   |.|  |.|
tytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

K
.
e
0049772 (Phosphotyrosine protein) phosphatases II 426-663 5.2e-29 97.4 In-house 40-281 (314) alignment 
Range on Protein: 426-663
Range on HMM: 40-281/314.0
HSASDNNQEKCRNPRVHCKDsTRIALQFPRGQYlGDFIHANRISGKplfNEFIMTQAPMKNTVDDF----------WRMV--WQEEVPYIVM--------
 .    |..| |.... . | .|  |..  ..   |.|.|. ..|    . || ||.|...||.||          ||||  ..  | .|||        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTSRKEPErceyywpkspsdpavtvpG--------GLRienfgvyqapdplfrvtH---------------LRLIGPDREERHVEHw
             |..  ..                   .         |.                                 ||.  || ..   |. 
elsrLdaAlgKtpllildgng..................neptaadlellk.................eelydpelferlgikylripvpDgsaplled.

qgdvnnssnmysPLNILRLLRN--ASKPVVIHDHLGVSRAACLVAAEIAICSLlrgptyKYPVQRAVQFLRQRRP-----FSIETPMQYIFVHRLVAFFF
             . .|.....  . .||..| . |..|....|.| . .  |      ..... |....|..||      .||...||.|... .  ..
............fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

R
.
k
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 426-658 7e-23 75.9 In-house 38-273 (315) alignment 
Range on Protein: 426-658
Range on HMM: 38-273/315.0
HSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSP
 .  ..|..| |   .   ||.|. |.    .   |.| |  | .    . .| .|.| | .||||||||.||.|  |||.| ..| ..  |  |||.  
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

SDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDRE--ERHVEHWQGDVNnSSNMYSPLNILRLLRN----ASKPVVIHDHLGVSRAACLVAAEIAI
.| .    | ...| . . .  |   |   .|     |     . . |        .. | |.... ..        ....|   || |.  .....  .
adsvef..GsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGv.dkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

CSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
  . |.      | . |. ||. ||. . |  .| |..  |
aqikrtr..svdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 426-658 1.6e-19 64.7 In-house 42-275 (439) alignment 
Range on Protein: 426-658
Range on HMM: 42-275/439.0
HSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERceyYWPKSPS-
  | . .| | |   |   | ||..||   |     .| || | |    . .| ||.| |.|.|||||.|... .  |||||   |  .   ||| .   
laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...ywpsdaev

---DPAVTVPGGLRIENFGVYQapdplFRVTHLRLIGpdREERHV-----EHWQgDVNNSSNMYSPLNILRLLRNAS-----KPVVIHDHLGVSRAACLV
   | || |   . . |. .       |.|   |  .  . || |       |  | |  ..    |. || .  |       |||.|   || |.  ..
cygdiavrvdrnielpnyvirg.....fkvfnerdtt..ekertvlqfhyiawp.dknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtii

AAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
| .||.  |      |  ..  |..||..|   ...  ||.|..  |
aldialeqlkl..enkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_CG7180_pd Subfamily CG7180 426-522 3.1e-19 63.7 In-house 36-133 (296) alignment 
Range on Protein: 426-522
Range on HMM: 36-133/296.0
HSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER-CEYYWPKS
.    .|.|| |.. |   | .|. |.   |.   |.| |  . .    .|.|.|.||.|.|||.|||.|..||.  .|.||   . .. .  |||. 
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnk
subfamily_PTPN13_pd Subfamily PTPN13 427-658 1.6e-27 91.5 In-house 32-265 (273) alignment 
Range on Protein: 427-658
Range on HMM: 32-265/273.0
SASDNNQEKCRNPRVHCKDSTRIALQFPRGqYL-GDFIHANRisGKPLFnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPKSP
. ...|..| |   |   | ||. |.   | |.  ..|...   ||  . |.|..| |. .||.|||.|||. ..  |.|.|. || .  .|. |||.| 
gkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv..gkdey.eyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

SDPaVTVPGGLRIENFGVYQAPDplFRVTHLRLIGPD-REERHVEHWQ------GDV-NNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEI
... ..| . |..|. .| .  .  | | .| ..  . .| |.| | .       .| ... ..   .  .| |.. . |.|.|   |. |.  |.. ..
nkk.lkvsnrlevellkvqkldg..fvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidv

AICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
..  . |    ...|.  |. ||..|   . |  |||||.. .
vlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 427-570 2.8e-16 54.2 In-house 28-170 (297) alignment 
Range on Protein: 427-570
Range on HMM: 28-170/297.0
SASDNNQEKCRNPRVHCKDSTRIALQfpRGQYLGDFIHANRIS--GKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKS
.  ..   | |   .   |.||. |.  |.    |.| |. .    ..    .|..| |...||||||..|....|  |||..  .|   ..|  |||..
akrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

PSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPdREERHVEHWQ
  .   .  | . .|    .        .| |.||    |.|.| | |
vqerlka..gdvvveflsstsdefdrviltelqliyr.sesrvvrhvq
subfamily_PTPRN_pd Subfamily PTPRN 427-523 1.4e-14 48.5 In-house 51-150 (297) alignment 
Range on Protein: 427-523
Range on HMM: 51-150/297.0
SASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISG-KPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSP
. ...| .| |.  |   | .|. |.    .   |.| |  |    |    .| ||.|. .|| |||.|||.. |  ||.||. .|   ..|. |||.  
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 428-663 5.8e-28 92.4 In-house 51-290 (305) alignment 
Range on Protein: 428-663
Range on HMM: 51-290/305.0
ASDNNQEKCRNPRVHCKDSTRIALQFPRgqyLGDFIHANRIsGKPLFNE--FIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSP
..| .. | |   | |.| . . |. |      |.|||| . | |.  |  || .| |. .|.|.|| || |. |  ||||    |    .|  ||| . 
sadiaitknryqdvpcqdqsavkldkps...psdyihanyv.gcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

SDpAVTVPGGLRIENFGVYQ--APDPLFRVTHLRLIGPDREERHVEH--WQ--GDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAI
 .  ... .|. .||    .    |.  ..| |.|     ..  | |  |    |        . |..|  .| .  |.|.|   |. |.  .|| |  .
ge.klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyil

CSLLRgPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
  .        |.   |. ||..| |||.. .||.|.||..  .| 
ekiae.nkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 430-658 6.2e-27 89.4 In-house 7-238 (250) alignment 
Range on Protein: 430-658
Range on HMM: 7-238/250.0
DNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER-CEYYWP--KSPSDP
 .|.|| |   .   ||.|. |.  .|.   |.| |  . |    . ||.||.|...|. ||||||..|..  |||||. || |. .. |||  |.    
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyG

AVTVPgGLRIENFGVYQAPDplFRVTHLRLIGpDREERHVEHWQ-GDVNNSSNMYSPLNILRLLRN-----ASKPVVIHDHLGVSRAACLVAAEIAICSL
 |||   |  |.|. |.     . ... .  . .|  |.... .  |     .. . |..|. ..       ..||...   ||.|. . .| .  .  |
dvtvs.llskeefadytkrk..lklskakkad.erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

LRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
 .    .  | . .. ||. || ..|.  ||.||....
kk..ekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 430-520 9e-10 32.4 In-house 49-139 (302) alignment 
Range on Protein: 430-520
Range on HMM: 49-139/302.0
DNNQEKCRNPRVHCKDSTRIALQFPRgqylGDFIHANRISGKPLFNEFIMTQAPMKNTV---DDFWRMVWQEEVPYIVMLTSRKEPER-CEYYWP
 .| .|.... | . ||... |.        ....| ...   | .. |..| | ....   ..|||||.||..  .|.|   .| ..  . ..|
kknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 430-522 9.5e-08 25.9 In-house 94-181 (244) alignment 
Range on Protein: 430-522
Range on HMM: 94-181/244.0
DNNQEKCRNPRVHCKDSTRIALQfpRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPercEYYWPKS
 ||  | |.      |  |. |   .|     .| |  .       |.|.|| |. .|  |||.|. .  |  .|.| | .|    . ||| |
pnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee...deywpds
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 431-658 1.9e-25 84.1 In-house 36-265 (281) alignment 
Range on Protein: 431-658
Range on HMM: 36-265/281.0
NNQEKCRNPRVHCKDSTRIALQF-PRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSPSdpa
 |..| |   . | | .|. |..    .   |.|||| |    |   .|.|| | |.|  |||||.|||.   ||||    |   |.|  |.|.      
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah...

vtvpGGLRIENFGVYQAPDPL---FRVTHLRLiGPDREERHVEHWQG------DVNNSSNMYspLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAIC
      |..... |      .   .  |.| |   . | | . ||        .| .||..   |.||| .|  | | |||   || |.  |.| |||. 
....cclqfdklsvsyedstvnkslvttrlnl.syegetrlithwlwkewpdwqvpessevm..lkilrkirarstppvihcsagvgrsgtlmaveialq

SLLRGPTYKyPVQRAVQFLRQ-RRPFSIETPMQYIFVHRLV
|.    |    ... |  ||   |  |..|  ||... ...
sihshftlp.dikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 431-664 2.7e-24 80.4 In-house 47-289 (305) alignment 
Range on Protein: 431-664
Range on HMM: 47-289/305.0
NNQEKCRNPRVHCKDSTRIALqfpRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK--EPERCEYYWPKSPSDPAV
....| |   | | |  |. |   .| .  ..|||| .|     . || ||||...|  ||| | .|. | .| ||   .    ..|  |..    |   
qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

TVPGGLRI----ENFGVYQ---APDPLFRVTHLRLIGPDREERHVEHWQ-GDVNNSSNMYSPLNILRLLRNA---SKPVVIHDHLGVSRAACLVAAEIAI
   .| .|    |  . ..     .   . | | . ||  . |.| |.   |  .     . | || || .|     |.|.|   |. |.  .|  |  .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyil

CSLLRGPTYKyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
  || |   .   .. .| .|..|  ||.|  ||.|||...  .||.
dqllagqiie.dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 431-523 6.1e-15 50.1 In-house 2-95 (237) alignment 
Range on Protein: 431-523
Range on HMM: 2-95/237.0
NNQEKCRNPRVHCKDSTRIALQFPRGQylGDFIHANRISGK-PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSP
.|. | |   . . | .|. |. . ..   |.| |. . |     ...| .| |.... ||||.|||||    |||||   |   ..|  |||.. 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd
Y_phosphatase Protein-tyrosine phosphatase 432-659 9.7e-50 164.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 432-659
Range on HMM: 1-234/235.0
NQEKCRNPRVHCKDSTRIALqfpRGQY-LGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDpaV
|..|.|.. . . |.||. |   .|.    |.|.|| ..| .  ..||.||.|.|.|..|||||||||.| .|||||| .|   | |..|||.. ..   
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..s

TVPGGLRIENF-GVY-QAPDPLFRVTHLRLIGPDR-----EERHVEHWQgDVNNSSNMYSPLNILRLLRNAS----KPVVIHDHLGVSRAACLVAAEIAI
.  | ...|.   .  .  .  .|...|.  . ..     .. |...|. | .  ..  | |...| ... .    .|||.|   ||.|....||..|..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..| .. .    |  .|. ||..|| ....  ||||......
eqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 432-659 9.7e-50 164.5 In-house 1-234 (235) alignment 
Range on Protein: 432-659
Range on HMM: 1-234/235.0
NQEKCRNPRVHCKDSTRIALqfpRGQY-LGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDpaV
|..|.|.. . . |.||. |   .|.    |.|.|| ..| .  ..||.||.|.|.|..|||||||||.| .|||||| .|   | |..|||.. ..   
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..s

TVPGGLRIENF-GVY-QAPDPLFRVTHLRLIGPDR-----EERHVEHWQgDVNNSSNMYSPLNILRLLRNAS----KPVVIHDHLGVSRAACLVAAEIAI
.  | ...|.   .  .  .  .|...|.  . ..     .. |...|. | .  ..  | |...| ... .    .|||.|   ||.|....||..|..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..| .. .    |  .|. ||..|| ....  ||||......
eqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 432-662 2.9e-35 116.9 In-house 1-171 (182) alignment 
Range on Protein: 432-662
Range on HMM: 1-171/182.0
NQEKCRNPRVHCKDSTRialqfprgqyLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTsrkeperCEYYWPkspsdpavtvp
|..| | . . . | .|            |.|.|| . |   ...||.||.|...|| ||.||.... . .||.||       .|.|||           
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywp...........

gglrienfgvyqapdplfrvthlrligpDREER---HVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSllrgptyKY
                            ...||   .. ... . ..  .... |....  .. ..||..| . ||.|...|||| . ..        ..
............................ellerlgiqylylpwpDhgvpdldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.......gv

PVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
... ||...|.||| ...|| ||.|..... ...
sleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 432-658 3e-14 47.8 In-house 8-237 (239) alignment 
Range on Protein: 432-658
Range on HMM: 8-237/239.0
NQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRIS---GKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDP
|. | |   .   | .|. |.    .   |.| |. .    | |  . .| ||  .. .  |||||.|||    |||||   |   ..|  ||| | |  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

AVtVPGGLR-IENFGvyqapDPLFRVTHLRLIGpDREERHVEHWQGDVNNSS--NMYSpLNILRLLRN-------ASKPVVIHDHLGVSRAACLVAaeia
.  .   ||  | |      | . |   .  .| . |||.| ...  |        |.   .| | |.        ..| |||   || |. ...     
cn.lrvtlrktevfa.....dyiirtfvmsqvg.qteeryvyqyhftvwpdkgvpqya.tavlglrrkitkdslpgarpwvihcsagvgrtgaflv....

ICSLLRGPTYKY--PVQRAVQFLRQRRPFSIETPMQYIFVHRLV
| ..||    .    .   |. .|. ||. ..|  ||.|.|  |
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 432-658 3e-14 47.8 In-house 7-236 (239) alignment 
Range on Protein: 432-658
Range on HMM: 7-236/239.0
NQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRIS---GKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDP
|. | |   .   | .|. |.    .   |.| |. .    | |  . .| ||  .. .  |||||.|||    |||||   |   ..|  ||| | |  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

AVtVPGGLR-IENFGvyqapDPLFRVTHLRLIGpDREERHVEHWQGDVNNSS--NMYSpLNILRLLRN-------ASKPVVIHDHLGVSRAACLVAaeia
.  .   ||  | |      | . |   .  .| . |||.| ...  |        |.   .| | |.        ..| |||   || |. ...     
cn.lrvtlrktevfa.....dyiirtfvmsqvg.qteeryvyqyhftvwpdkgvpqya.tavlglrrkitkdslpgarpwvihcsagvgrtgaflv....

ICSLLRGPTYKY--PVQRAVQFLRQRRPFSIETPMQYIFVHRLV
| ..||    .    .   |. .|. ||. ..|  ||.|.|  |
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 435-511 3.1e-06 21.1 In-house 46-118 (312) alignment 
Range on Protein: 435-511
Range on HMM: 46-118/312.0
KCRNPRVHCKDSTRIALQFPRGQYlgdfIHAN--RISGKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE
  | | . | |  |..|      |    ||||  .|  ||  . |. ||.|..||.  ||...       |..|..  |
lnrypniqcwdrgrftlagdenfy....ihanfvkictkp..erfvctqgplentcthfwqlalslgstsiillcgfve
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 436-659 3e-26 87.1 In-house 45-268 (288) alignment 
Range on Protein: 436-659
Range on HMM: 45-268/288.0
C--RNPRVHCKDSTRIALQfprgQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS--RKEPERCEYYWPKSPSDPAVTVP
.  |  .. . | ||. |.         .|.|| .| ..  . .| .|||.. |.. .|.|. ...| |||||.    |  |. . |.|    . |    
trdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

GglRIENFGVYQAPDPLFRVTHLRLIGPDREER-----HVEHWQGDVNnSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLlRGPTy
          ..  | | .|. ||   .  |.      |. .|. |     |  |||..|  |..  ||.|.| . || |.. |.   ||. || | .  
l..ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgv.PenylsplrllevlkslqkPivvhssaGvGrtgtlililialesl.rldd.

KYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
   ... .. ||. |  .|.| |||..|||.| 
flgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 437-663 2.5e-28 93.8 In-house 25-265 (270) alignment 
Range on Protein: 437-663
Range on HMM: 25-265/270.0
RNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKP-LFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDPAVTVPGG
|   .  .  ||. |.  . .    .| || . |     ...| ...|...|. .||||.|.|.|. |||.|  .|   ..|| |||..| .   .  | 
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgk

LRIENfgVYQAPDPLFRVTHLRLIgPDREERHVEHWQ-------GDVNNSSNMYSPLNILRLLRNA---------SKPVVIHDHLGVSRAACLVAAEIAI
... .  . .. .  ...|.|||   . |||.. |..       | .... .  |. ..|..||.          ..|...|.  || |. .|.| .||.
ikvla..lseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiav

CSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
. | .  | |  | . .. ||. |.  ...| || |... |. . .
rlLee..tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0044763 (Phosphotyrosine protein) phosphatases II 445-658 7.2e-23 76.6 In-house 3-167 (178) alignment 
Range on Protein: 445-658
Range on HMM: 3-167/178.0
DSTRIALQFPRGQYLGDFIHANRISGKplfneFIMTQAPMkntvDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSPSdpavtvpgglrienfgvy
| ||  |. ..|   .|.|.|..| .      ......|.     |........ . .||.||. .|. .  |  |||.. .                  
drtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..................

qapdplfrvthlrligpdreeR---HVEHWQG-DVNNSSNMYSPLNILRLLR-NASKPVVIHDHLGVSRAACLVAAEIAICSllrgptyKYPVQRAVQFL
                         |.    . . . .. ..  ..... .. .  .||..| . ||.|...|||| . ..        ..... |....
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.......glsleeaielv

RQRRPfSIETPMQYIFVHRLV
|.|||  ...| |. ..... 
rerRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 445-662 1.7e-20 68.3 In-house 31-259 (290) alignment 
Range on Protein: 445-662
Range on HMM: 31-259/290.0
DSTRIALQFPRGQYLGDFIHANRISGkPLFNEFIMTQAPMKN-------TVDDFWRMVWQEEVPYIVMLTSRKEPER------CEYYWPKSpSDPAVTVp
  ||..|.    ..  |.|||||..  |   ..|.||.| ..       |. .|| |. ||.|  .|||  ..|...      |. | |.|  .  ... 
eatrvvLkgygkrfnddyiHAnrvtc.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes.vgeelkf.

GGLRIENFGVYQAPDPLFRvtHLRLIGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAiCSLLRGPTYK
.|| ..     .  |   |  .| .   |.||  |.| .     ..|   .  . |.... ...   ||..|.. |.|| |.| | ... . .. . . .
kgltvkCkskekeddvetR..elvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilg.yQkiaetsgs

YPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
  .. ... ||..|   | ..... ||   . . .
vkledvlkalrkqralaitsalelafvdagivlla
subfamily_CG42327_pd Subfamily CG42327 446-530 1.2e-10 35.6 In-house 42-129 (319) alignment 
Range on Protein: 446-530
Range on HMM: 42-129/319.0
STRIALQFPRGQYLGDFIHANRISGK-PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPKSPSDPAVTV
 ||. ||    .    ...|. . |     | .| .|......  ||||.||.     || ||.  |    .|  |.| . . .   .
etrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl
0046846 (Phosphotyrosine protein) phosphatases II 456-662 2.6e-29 97.6 In-house 8-173 (176) alignment 
Range on Protein: 456-662
Range on HMM: 8-173/176.0
GQYLGDFIHANRISGKplfnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERC--EYYWPKsP-SDPAvtvpgglrienfgvyqapdplfrvt
 ..  |.|.|| | |      .| ||.|. .|. ||..|.... . ..|.||...| .|.   .|||    .                            
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi.........................

hlrligpdreE-RHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICsllrgpTYKYPVQRAVQFLRQRRP-FSIETPMQ
          .  |.    ..| ... ... |...|  ... .||..| . |..|...|||| . ..       . ..|. |....|..|| ....|| |
..........qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel......ekglsveealalvreqRplgavqtpeQ

YIFVHRLVAFFF
| |... . ...
yrflyefellll
0051429 (Phosphotyrosine protein) phosphatases II 459-683 1.1e-29 99.3 In-house 3-246 (272) alignment 
Range on Protein: 459-683
Range on HMM: 3-246/272.0
LGDFIHANRISGKPL---FNEFIMTQAPMKNTVDDFWRMvWQEEVPYIVMLTSRKEPER--CEYYWP--------KSPSDPAVTVPGGLRIENFGVYQAP
|.. |.|. ..|       . .. ...|...|..||||. ... . .||.|.|  | .|  |..|||          ....     | ||. .. ... .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYS--PLNILRLLRNaSKPVVIHDHLGVSRAACLVAAEIAIcsLLRGPTYKYP--------VQRAVQ
| . |.  |.|. .  | |.| |..       .  .   |..|.||.. ..||..| . |..| ...||. . .  |  . .  .         ...||.
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeave

FLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKELDVDYERWLQER
 ||..|| ...|..||.|... .. ..| ....  |    . ....|.
elraqrpgavqteeqylflyeallellrsllsvraeyllaaldaidee
0043147 (Phosphotyrosine protein) phosphatases II 460-655 1.2e-28 95.4 In-house 5-154 (172) alignment 
Range on Protein: 460-655
Range on HMM: 5-154/172.0
GDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRkeperceyywpkspsdpavtvpgglrienfgvyqapdplfrvthlrLIGP
 |.|.|. ...    ..||.||.|. ||..|||||.... . .||.||..                                              |  |
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

DREERHVEHWQ------GDVNNSSNMYSPLNILRL--LRNASKPVVIHDHLGVSRAACLVAAEIAIcsllrgptYKYPVQRAVQFLRQRRPFSIETPMQY
. .||.. ...      ..| ... ... |....   ... ..||..| . ||.|...|||| . .        ...... ||...|..|| ....| ||
ellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsqy

IFVH
.|..
rfly
0051082 (Phosphotyrosine protein) phosphatases II 460-656 2.6e-22 74.5 In-house 3-147 (151) alignment 
Range on Protein: 460-656
Range on HMM: 3-147/151.0
GDFIHANRISGKplfneFIMTQAPMKntvdDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPsdpavtvpgglrienfgvyqapdplfrvthlrligp
 |.|..... |      .. ...|.     ||....... . .||.|.| .|.. |  |.|.                                      
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

dreeRHVEHWQGDVNNSSNM----YSPLNILRLLRNA-SKPVVIHDHLGVSRAACLVAAEIAICSllrgptykYPVQRAVQFLRQRRPFSIETPMQYIFV
    ..| |.. . .   ..     . |..|.||..  ..||..| . |..| ..|||. . ..         .... |....|..|| .. ...|..|.
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkrpgvvqpnqqflfq

HR
..
lf
0036282 (Phosphotyrosine protein) phosphatases II 461-656 3.9e-24 80.7 In-house 3-164 (174) alignment 
Range on Protein: 461-656
Range on HMM: 3-164/174.0
DFIHANRISGKPLFNEFIMTQAPMKntvddFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPKspsdpavtvpgglrienfgvyqapdplfrvthlrliG
|.|.|. ...    ...| .|.|..     ||.|.... . ..|||.. ||..  .|  |||                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................l

PDREERHVEHWQG---DVNNSSNM-YsPLNILRLLRNA-----SKPVVIHDHLGVSRAACLVAAEIAICSLLrgptykYPVQRAVQFLRQRR---PFSIE
.. .||.. ...    . ..  ..    |........|     ..||..| . ||.|...|||| . .. ||       ... |....|..|   | ...
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll......eslvdaldlvrelRlqrpgmvq

TPMQYIFVHR
|| ||.|.. 
tpsQyrflyy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 461-523 2.3e-12 41.3 In-house 84-154 (350) alignment 
Range on Protein: 461-523
Range on HMM: 84-154/350.0
DFIHANRISGK-------PLFnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSP
|.| || .. .       | |  .| ||||...|||||.... . .|. |..|||  |   |.|. ||..  
DYinanYlkltrfsveinpdf.kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
0049260 (Phosphotyrosine protein) phosphatases II 471-655 1.4e-26 88.5 In-house 5-143 (152) alignment 
Range on Protein: 471-655
Range on HMM: 5-143/152.0
KPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWpkspsdpavtvpgglrienfgvyqapdplfrvthlrligpdreerHVEH
    .||| ||.|. ||..|||||...  . .|||||.. |  .  ||.|.                                             .. |
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylh

WQ---GDVNNSSNMYSPLNILRL--LRNASKPVVIHDHLGVSRAACLVAAEIAIcsllrgptYKYPVQRAVQFLRQRRPFSIETPMQYIFVH
..   . | ..| .   |...    ... ..||..| . ||.|...|||| . .        ...... ||...|..|| ....| |..|..
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 473-521 5e-08 26.7 In-house 234-281 (440) alignment 
Range on Protein: 473-521
Range on HMM: 234-281/440.0
LFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEpERCEYYWPK
  | || || |.  || ||||.| . ..  |.||   ..   |  ||| 
kknafiatqmpldstvldfwrlvhdyristiimlnqlnd.ktcsiywpv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 475-522 2e-06 22.1 In-house 28-72 (130) alignment 
Range on Protein: 475-522
Range on HMM: 28-72/130.0
NEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPercEYYWPKS
.|...||.|. .|  |||.|. .  |  .|.| | .|    . ||| |
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveee...deywpds
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 476-525 2.3e-08 28.4 In-house 6-57 (199) alignment 
Range on Protein: 476-525
Range on HMM: 6-57/199.0
EFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE-PE-RCEYYWPKSPSD
 .| || |...|. |||.|||.    .|||.   .   |    .||| . | 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 476-525 2.3e-08 28.5 In-house 5-56 (198) alignment 
Range on Protein: 476-525
Range on HMM: 5-56/198.0
EFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE-PE-RCEYYWPKSPSD
 .| || |...|. |||.|||.    .|||.   .   |    .||| . | 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg
subfamily_hpo-7_pd Subfamily hpo-7 485-663 7e-12 39.8 In-house 44-228 (263) alignment 
Range on Protein: 485-663
Range on HMM: 44-228/263.0
KNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDPAVTvpGGLRIENFGVYQapDPLFRVTHLRL-IGPDREERHVEHWQ--G--DVNNSS
 .|.| |.... | .   .|||.  .|   |.|. |.|    .  .     . .    | .  |.| .  .|   .|  .. . |.|..  |  ..|.  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl..anvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpe

NMYSPLNILRLLRNAsKPVVIHDHLGVSRAACLVAAEIAIC----SLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
.. . ||||.. ||  |..|.|   |. |.|  . ||..      ||   .| .    . .. ||..|. .|.||||  |   .|  |. 
lareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 487-662 1.4e-13 45.6 In-house 40-221 (255) alignment 
Range on Protein: 487-662
Range on HMM: 40-221/255.0
TVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSPSDPAVTVPGGLRIENfgvyQAPDPLFRVTHLRL-IGPDREERHVEHWQ--GDVNNS--SNM
||| |.... | .   .|||.  .|   |.|. |.|    .  .     .   .     . |...|  .. . .|  .. . |.|..  | ...    . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

YSPLNILRLLRNAsKPVVIHDHLGVSRAACLVAAEIAIC----SLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
   ||||.. |.. |.||.|   |. |.| .| ||..      || . .| .    . .. ||..|. .|.||.|  |   .|  ..
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 571-659 5.2e-15 50.9 In-house 59-140 (145) alignment 
Range on Protein: 571-659
Range on HMM: 59-140/145.0
GDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICsllrgptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|  . .. ... |.... .... .||..| . ||.|...|||| . ..       ...... |....|..||.....| |..|..... 
gvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.......lgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 571-656 1.2e-14 49.7 In-house 61-139 (144) alignment 
Range on Protein: 571-656
Range on HMM: 61-139/144.0
GDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAIcsllrgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHR
|  . .. ... |.... ... ..||..| . ||.|...|||| . .       ....... |....|.|||.....| |..|...
gvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.......klglsleealalvrsrrpgavpnpgqlrfLle
PTPc_DSPc_SM00012 576-659 1.1e-16 56.3 In-house 19-104 (105) alignment 
Range on Protein: 576-659
Range on HMM: 19-104/105.0
SSNMYSPLNILRLLRNA---SKPVVIHDHLGVSRAACLVAAEIAICSLLRGPtYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|... . |. ..  .|.   |||||.|.. ||.|....||..|....| ..  ... ... |. ||..|| ...| .||.|..| ..
sdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 583-662 6.5e-06 20.1 In-house 199-276 (312) alignment 
Range on Protein: 583-662
Range on HMM: 199-276/312.0
LNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSlLRGPTyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
| .|  ...  |||. |   || |.  |.  |  |.. || |  |  |. .  .||. |  |...  ||... | |  |.
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaa.lrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
PTPc_motif_SM00404 583-652 7.4e-06 20.9 In-house 70-131 (140) alignment 
Range on Protein: 583-652
Range on HMM: 70-131/140.0
LNILRLLRNASKPVVIHDHLGVSRAACLVAAEIaicslLRgpTYKYPVQRAVQFLRQRRpFSIETPMQYI
|....  ..  . |..|  .|||| |.|..|..     .|  .... .. |..|...||  .|.  ....
ldfienaekkggkvlVHCqaGvSRSatliiaYl.....mr..yrqlslaeayefvkerR.piispnlnfv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 588-666 6.8e-08 26.3 In-house 213-289 (302) alignment 
Range on Protein: 588-666
Range on HMM: 213-289/302.0
LLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVI
.  .|....||  . |. ||. .... .|...| .|   .  ..  |. .|. || ....  ||..... ......  .
kkikadentvivSknGaGRagafltlavaveklqkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_PTPN14_pd Subfamily PTPN14 590-661 1e-06 23.0 In-house 226-295 (300) alignment 
Range on Protein: 590-661
Range on HMM: 226-295/300.0
RNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFF
.... ||..|   || |.  |. ... | .|  .   .  ...... ||..| . ..|  || ||....  .
keskPPvlvhCsaGvGrtGvlilsdlliatlehne..eidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_CG42327_pd Subfamily CG42327 590-661 4.3e-06 20.6 In-house 244-314 (319) alignment 
Range on Protein: 590-661
Range on HMM: 244-314/319.0
RNASKPVVIHDHLGVSRAACLVAAEIAICSLlRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFF
|.   |.|.|   || |.  ..|..||| ||   .     . . |...|. |  .. |  || |... .  .
resqGPlvvhcsdGvGrtGlviasdiairsl.eeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey