Gene F13D11.3 in Caenorhabditis elegans

Synonym: CELE_ZK757.2, ZK757.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP058_AA protein Get Run
CeleP058_AA_8-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0036282 (Phosphotyrosine protein) phosphatases II 7-149 4.3e-22 74.1 In-house 8-171 (174) alignment 
Range on Protein: 7-149
Range on HMM: 8-171/174.0
ALLSITQVRPHLFLAGYGCITPSLLKQYNITHGVDCTNLKTKP----------------IKGLDRIEVPVDDNTLAKITQyFEPVVKYIEDAKQQ--GHN
  |... . |.|.. ..      .||...||. |.....| .                   |.  . .|..|..   ... .. .||..|.| ..  |. 
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

TVIYCAAGVSRSATLTIVYLMVTENL-SLEEAYLQVNQVR---PIISPNIGFWRQMIDFEKQRNG
... | |||.|..|| . ||| .  | ||..|.  | ..|   | . .. ...|.  .|||. .|
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
subfamily_DSP14_pd Subfamily DSP14 8-157 1.1e-59 194.9 In-house 4-154 (157) alignment 
Range on Protein: 8-157
Range on HMM: 4-154/157.0
LLSITQVRPHLFLAGYGCITPSLLKQYNITHGVDCT-NLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
| ...|..|.|||.|.......|||...||. ...| .|.....|...|..|||.||. ||....|..|...||..|..|..|...|.|||||||.|...
laalsqitpsLflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNGNASVELIS
||| .|.|||.||| .|...||||.||.|||.|.||.||. .|..||....
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvd
subfamily_DSP10_pd Subfamily DSP10 9-149 2e-35 116.0 In-house 12-155 (159) alignment 
Range on Protein: 9-149
Range on HMM: 12-155/159.0
LSITQVRPHLFLA-GYGCITPSLLKQYNITHGVDCTNLKTKPIK--GLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTI
  ..|| |.|||  . .    ..|...|||. .. |.   .  .  .|    .|| |..  .. ||||  ...||.|...|.. ...| ||.|||||..|
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

VYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNG
 |||   ||||..||  |.. |||||||..|  |...|||. | 
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
0044763 (Phosphotyrosine protein) phosphatases II 9-149 2.2e-33 110.8 In-house 21-172 (178) alignment 
Range on Protein: 9-149
Range on HMM: 21-172/178.0
LSITQVRPHLFLAGYGCIT-PSLLKQYNITHGVDCTNLKTKPIKGL----------DRIEVPVDDNTLAKITQYFEPVVKYIEDAK-QQGHNTVIYCAAG
. .... |.|.|.....   . |||...||| |..|. .  .  ..            . .|..|..   ....|. .|..||.|  ..|......| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSATLTIVYLMVTENLSLEEAYLQVNQVRPiISPNIGFWRQMIDFEKQRNG
|.||.|| . ||| . .||||||. .| ..|| |.|| |..||...||.. ..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP19_pd Subfamily DSP19 9-147 1.4e-30 100.6 In-house 10-150 (152) alignment 
Range on Protein: 9-147
Range on HMM: 10-150/152.0
LSITQVRPHLFLAGYGCI-TPSLLKQYNITHGVDCT-NLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
|....|.|.|.|.      . . ||. .||| .. . ....   | .   .... |.  .....|.. ....||.|...    .. | |||||||.. | 
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
||| .|.||||||. .| ..|| |.|| ||..|. ..|.. 
ylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP8_pd Subfamily DSP8 10-146 5.5e-28 91.5 In-house 14-153 (159) alignment 
Range on Protein: 10-146
Range on HMM: 14-153/159.0
SITQVRPHLFLAG-YGCITPSLLKQYNITHGV--DCTNLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
 .|.. ..|.|      .  .||....|.. .  ...  |.. .|    . ||| |.   |. ..|.  |..|. ||..  . .... || |||||. | 
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
|.| | ..||.|||  | . || ||||. |  |....||.
yimktlemsldeayrfvkekrptispnlnflgqLleyeke
PTPc_motif_SM00404 11-145 5e-42 138.1 In-house 2-139 (140) alignment 
Range on Protein: 11-145
Range on HMM: 2-139/140.0
ITQVRPHLFLAGYGCIT-PSLLKQYNITHGVDCTNLKTK--PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVY
.... |||.|...  .. | |||...||| ...|. ...    .|  ....|.|||. .|...|.. |...||.|...|.. ...|.|||||||||.|.|
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
|| ...|||.|||  |.. |||||||..|.||.|..||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP1_pd Subfamily DSP1 11-148 2.7e-32 106.1 In-house 18-157 (163) alignment 
Range on Protein: 11-148
Range on HMM: 18-157/163.0
ITQVRPHLFLAGY-GCITPSLLKQYNITHGVDCTNLKT-KPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYL
.... ..|.| .       ..||. .||. .....       . .   .....|.. | |...||.|...|...|...    |.|.||.|||.|| ..||
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRN
| |...|||||.  | |.|.|||||.|| .|....||.  
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP6_pd Subfamily DSP6 11-147 1.8e-29 96.3 In-house 14-154 (158) alignment 
Range on Protein: 11-147
Range on HMM: 14-154/158.0
ITQVRPHLFLAG-YGCITPSLLKQYNITHGVDCTNL---KTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
  .. |.|.|     .    .||...| . .. |.    | .  . |   ..|..|.  ......|   ...|..|...  . ...| ||.||| |.|. 
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
||| ...|||..||  |.. .. ||||  |  |..|||.. 
ylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_DSP15_pd Subfamily DSP15 11-152 6.3e-28 91.8 In-house 2-144 (151) alignment 
Range on Protein: 11-152
Range on HMM: 2-144/151.0
ITQVRPHLFLAGYGC-ITPSLLKQYNITHGVDCTNLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLM
|..| | |.|...       |||. |||| .   . . | .| ..   ....| . ||....|.  |..| ... ...| ...|.||||||.||...|||
iskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNGNAS
   .|. ..|   ... | .  ||.|| ||. ..||..  .  
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyr
subfamily_DSP12_pd Subfamily DSP12 11-146 6.8e-28 92.0 In-house 2-142 (155) alignment 
Range on Protein: 11-146
Range on HMM: 2-142/155.0
ITQVRPHLFLAGYGCITP-SLLKQYNITHGVDCTNLKT---KPI-KGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTI
.... | |.|.|   ..  .|||...||| .  .. .    |.  . ...  ....|.  . | .... .|..||.| ... . .. |.||||||.|. |
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

VYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
 ||| .|.||||.|.  |....| |.|| || .|.  ||| 
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
0048076 (Phosphotyrosine protein) phosphatases II 12-147 8e-29 95.6 In-house 5-142 (145) alignment 
Range on Protein: 12-147
Range on HMM: 5-142/145.0
TQVRPHLFLAGYGCIT-PSLLKQYNITHGVDCTNLKTKP-IKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLM
... |.|.| .. .     |||...||. ...|. .. .  .|.  . .|..|..   ...... ....||.| ..|......| |||.|..|| . |||
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
 ....|||||. .| . ||.. || |..|....||.. 
lllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 13-145 1.5e-27 91.5 In-house 6-142 (144) alignment 
Range on Protein: 13-145
Range on HMM: 6-142/144.0
QVRPHLFLAGYGCI-TPSLLKQYNITHGVDCTN---LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYL
.. |.|.| .. .     |||...||. ...|.          |.  . .|..|.    ...... ....||.| ..|......| |||.|..|| . ||
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
|....||||||. .| . ||.. || |..|.....||
mkklglsleealalvrsrrpgavpnpgqlrfLleyek
0046846 (Phosphotyrosine protein) phosphatases II 13-147 1.9e-22 75.3 In-house 14-172 (176) alignment 
Range on Protein: 13-147
Range on HMM: 14-172/176.0
QVRPHLFLAGYG-----------CITPSLLKQYNITHGVDCTNLKTKPIK------------GLDRIEVPVDDNTLAKItQYFEPVVKYIEDAKQQGHNT
.. ..|.| ..                 .||...||. |..|... .               |.  . .|..|..   . .... ....|..| ..|...
yinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpv

VIYCAAGVSRSATLTIVYLMVT-ENLSLEEAYLQVNQVRP-IISPNIGFWRQMIDFEKQR
.. | ||..|..|| . ||. .  .||.|||. .| ..||  . .. ...|.  .||.. 
lVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 14-146 4.1e-24 79.1 In-house 123-257 (263) alignment 
Range on Protein: 14-146
Range on HMM: 123-257/263.0
VRPHLFLAGYGCIT-PSLLKQYNITHG-VDCTNLKTKPIKGLDRIEV-PVDDNTLAKITQYFEPVVKYIEDAKQQGHnTVIYCAAGVSRSATLTIVYLMV
. ..||| |  . .  |.||. ..||  .  ....    | .  . .  ..|   |.| |.|| .  .||. ...|   ...| ||||||.||.| ||| 
iidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmk

TENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
 ..| ..||.  | . || | ||.||  |.  .||.
kqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk
0051429 (Phosphotyrosine protein) phosphatases II 14-146 4.1e-17 58.2 In-house 19-223 (272) alignment 
Range on Protein: 14-146
Range on HMM: 19-223/272.0
VRPHLFLAGYG-----CITPSLLKQYNITHGVDCTNLK-------TKPIKGLDRIEVPVDDNTLAKITQYF-----------------------------
|.|...... |     .     ||...|.. || ...         . . |.... .|. |..   |....                             
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------EPVVKYIEDAKQqGHNTVIYCAAGVSRSATLTIVYLMVtENLS--------------LEEAYLQVNQVRPIISPNIGFWRQ
                   |.... .|   . |.. .. |.||..|..|.  ..|.. ...|              ||||. .. ..|| . .. .....
arevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

MIDFEKQ
  .....
lyealle
subfamily_STYX_pd Subfamily STYX 16-145 9.2e-19 61.1 In-house 17-155 (166) alignment 
Range on Protein: 16-145
Range on HMM: 17-155/166.0
PHLFLAGYGCITPSL---LKQYNITHGV------DCTNLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
| |||  | .   |    ||.  ||| |      ... .| .  . .  . . | |||. .| .|.  | ..|.|. |.| . ...  ||.||||.| | 
pglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalvia

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
|.| |  |   ||.. |.. |  |.|| || .|. ..| 
yimetyglkyreafayvqerrfcinpnegfvsqlkeyea
DSPc Dual specificity phosphatase, catalytic domain 18-146 7.1e-39 127.7 Pfam-A 1-133 (133) alignment 
Range on Protein: 18-146
Range on HMM: 1-133/133.0
LFLAGYGCITPSLLKQYNITHGVDCTNLKTK----PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTEN
|.|... .....||....||. ...|. ...      .  .....||.|.| .||....| .|..||.|.|.|.. ...|.||.||||||.|.||| |.|
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

LSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
|||.|||  |.. |..||||.||.||....|..
lslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 18-146 7.1e-39 127.7 In-house 1-133 (133) alignment 
Range on Protein: 18-146
Range on HMM: 1-133/133.0
LFLAGYGCITPSLLKQYNITHGVDCTNLKTK----PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTEN
|.|... .....||....||. ...|. ...      .  .....||.|.| .||....| .|..||.|.|.|.. ...|.||.||||||.|.||| |.|
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

LSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
|||.|||  |.. |..||||.||.||....|..
lslneAyefvkerrskispnagflrqLleyerk
0041856 (Phosphotyrosine protein) phosphatases II 27-150 4.6e-25 83.7 In-house 50-175 (182) alignment 
Range on Protein: 27-150
Range on HMM: 50-175/182.0
TPSLLKQYNITHGVDCTNLK----TKPIKGLDRIEVPVDDNTLAKitqyFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQ
   .||...||. |..|.        .  |.  . .|..|..       .. ....||.....|..... | |||.|..|| . ||| . ..|||||. .
flrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavkl

VNQVRP--IISPNIGFWRQMIDFEKQRNGN
|.. ||  .|.|| .|..|.. .|......
vrsrRpgmvitpnqyfflqlallellllkk
0045098 (Phosphotyrosine protein) phosphatases II 28-146 6.5e-23 76.9 In-house 81-270 (278) alignment 
Range on Protein: 28-146
Range on HMM: 81-270/278.0
PSLLKQYNITHGVDCTNL--------------------------------------------------KTKPIKGLDRIEV-PVDDNTLAKIT--QYFEP
  .|....||. | .|.|                                                  .. .  |.  .   |..|..    .  ..|  
wrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfle

VVKYIEDAKQ--------------QGHNTVIYCAAGVSRSATLTIVYLMVTE---NLSLEEAYLQVNQVRPI-ISPNIGFWRQMIDFEKQ
....|..| .              .|. ... | |||.|..|| ..||| .    ...|.||. .. . ||. . .| ...|....|. .
llefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
0037934 (Phosphotyrosine protein) phosphatases II 28-146 3.7e-21 71.3 In-house 65-240 (243) alignment 
Range on Protein: 28-146
Range on HMM: 65-240/243.0
PSLLKQYNITHGVDCTNL----------------------------------------------KTKPIKGLDRIEVPVDD----NTLAKITQYFEPVVK
  .|....||. |..|.|                                              .  .  .     .|. |    .. . . .... | .
wrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevre

YIED-----AKQQGHNTVIYCAAGVSRSATLTIVYLMVTE-NLSLEEAYLQVNQVRPI-ISPNIGFWRQMIDFEKQ
.||.     |  .|. ... | |||.|..|| . ||| .  ...||||. .. . ||  . .. ...|. ......
fieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 28-144 4.1e-20 67.4 In-house 26-150 (151) alignment 
Range on Protein: 28-144
Range on HMM: 26-150/151.0
PSLLKQYNITHGVDCTNLK-------TKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQ-GHNTVIYCAAGVSRSATLTIVYLMVtENLSLEEA
  |||...|.. |......         |  |.. . .|..|..  .. ..|. |....| . .. .......| ||..|..|| ..|||  ...|||||
lellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

YLQVNQVRP-IISPNIGFWRQMIDFE
. .. . || .. || .|. |.....
leeyrlkrpgvvqpnqqflfqlfall
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 29-146 4.6e-25 81.9 In-house 27-146 (148) alignment 
Range on Protein: 29-146
Range on HMM: 27-146/148.0
SLLKQYNITHGVDCTNLKTKPI--KGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQV
. ||. ..|. |..|. . ...  .|.. ..|..||.    . ..||....... ||..|.  .. .  |||||. |....|. ... ||.||.  |.. 
ealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvksk

RPIISPNIGFWRQMIDFEKQ
|. . || || .|. ..|..
rryvdpnlgfLkqLaeleqa
0042113 (Phosphotyrosine protein) phosphatases II 29-146 2.4e-20 68.5 In-house 66-241 (245) alignment 
Range on Protein: 29-146
Range on HMM: 66-241/245.0
S----LLKQYNITHGVDCTNLK-----------------------------------------------TKPIKGLDRIEVPVDDNTLAKITQYFEPVVK
     .|....||. |..|..                                                 .. ...    .|..|.. . ...... ...
edfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfle

YIEDAKQ--QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
....| .  ... ... | |||.|..|. ..|||      . ..|||||. .... || . .. ...|........
fvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPMT1_pd Subfamily PTPMT1 29-146 2e-17 58.1 In-house 52-167 (171) alignment 
Range on Protein: 29-146
Range on HMM: 52-167/171.0
SLLKQYNITHGVDCTNLKTKPikGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
|| ..|.... ...|.  .|   |.. ..... | | |  ..  |  |..||. ...|.   . | || .||||| . ||| .|.||.|||   ... |.
slneeyelkalansteewkkl..gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk

IISPNIGFWRQMIDFEKQ
||  .   |...  .|..
iirlakkqwkalqeyeek
0043147 (Phosphotyrosine protein) phosphatases II 30-147 2.4e-26 87.9 In-house 39-160 (172) alignment 
Range on Protein: 30-147
Range on HMM: 39-160/172.0
LLKQYNITHGVDCTN----LKTKPIKGLDRIEVPVDDNTLAkITQYFEPVVKYIED--AKQQGHNTVIYCAAGVSRSATLTIVYLMVtENLSLEEAYLQV
.||...||| |..|.     .     |.  . .|..|..   ...... ....|..  |...|. ... | |||.|..|| . |||  ..||||||. .|
mlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalv

NQVRPIISPNIGFWRQMIDFEKQR
 . ||....| ...|.  .|||..
rekRpgavqnpsqyrflyyfekll
0049260 (Phosphotyrosine protein) phosphatases II 30-147 9.7e-25 82.4 In-house 28-149 (152) alignment 
Range on Protein: 30-147
Range on HMM: 28-149/152.0
LLKQYNITHGVDCTNLKTK----PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIED-AKQQGHNTVIYCAAGVSRSATLTIVYLMVtENLSLEEAYLQVN
.||...||. | .|.|  .      ..   . .|..|..  ...|... ... ||  |...|..... | |||.|..|| . |||   ..|||||. .| 
mlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvr

QVRPIISPNIGFWRQMIDFEKQR
. ||.. || |..|.  .|||..
ekRpgavpnpgqlrflyefekll
0040439 (Phosphotyrosine protein) phosphatases II 30-145 3e-20 68.3 In-house 73-243 (249) alignment 
Range on Protein: 30-145
Range on HMM: 73-243/249.0
LLKQYNITHGVDCTNLKT--------------------------------------------KPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQ-
.|....||. |..|.|.                                             .  . .    ... |    .. ..||.....|| ... 
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
     .|. ... | |||.|..|. . |||      . ...||||. .... || . .| ...|. .....
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 30-145 3.8e-20 68.3 In-house 126-301 (307) alignment 
Range on Protein: 30-145
Range on HMM: 126-301/307.0
LLKQYNITHGVDCTNLK-----------------------------TKPIKGLDRIEVPVDDN-----------------TLAKITQYFEPVVKYIEDAK
.|.....|. |..|.|.                             ..  .|. .  ..| |.                    .. ..||.... || ..
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

Q------QGHNTVIYCAAGVSRSATLTIVYLMVTEN--------LSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
.      .|. ... | |||.|..|. . ||| .          ..|.||. .. . || . .| ...|. .....
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
subfamily_MKPLT_pd Subfamily MKPLT 30-146 1e-19 64.6 In-house 42-159 (164) alignment 
Range on Protein: 30-146
Range on HMM: 42-159/164.0
LLKQYNITHGVDCTN-LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
.||. .||| |  ..  | .  | ..  .| |.|..  ......| . |.. || . |   ...|  |.|||.. |. .|.  .   |.|||  . . | 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

IISPNIGFWRQMIDFEKQ
|..|| || .|.  ||. 
ivapnrGflkqlakfeel
subfamily_MKPLV_pd Subfamily MKPLV 30-146 1e-19 64.6 In-house 42-159 (164) alignment 
Range on Protein: 30-146
Range on HMM: 42-159/164.0
LLKQYNITHGVDCTN-LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
.||. .||| |  ..  | .  | ..  .| |.|..  ......| . |.. || . |   ...|  |.|||.. |. .|.  .   |.|||  . . | 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

IISPNIGFWRQMIDFEKQ
|..|| || .|.  ||. 
ivapnrGflkqlakfeel
0040438 (Phosphotyrosine protein) phosphatases II 30-145 1e-18 63.1 In-house 105-273 (317) alignment 
Range on Protein: 30-145
Range on HMM: 105-273/317.0
LLKQYNITHGVDCTNLKTK----------------------------PIKGLDRIEVPVDDN----------------TLAKITQYFEPVVKYIEDAKQQ
.......|. |  |.|. .                              .|    ...| |.                .  .. ........ .| ....
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
    |. ... | |||.|..|. ..|||      ......|||. .... || . .. ...|...|.. 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall
0039614 (Phosphotyrosine protein) phosphatases II 30-146 5.7e-18 60.9 In-house 120-287 (297) alignment 
Range on Protein: 30-146
Range on HMM: 120-287/297.0
LLKQYNITHGVDCTNLKTKPIKG--------------------------LDR-----------------IEVPVDDNTLAKITQYFEPVVKYIEDAKQ--
.......|. |  |.|. .  |                             .                   ..  |..   .....  .......| .  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
 .|. ... | |||.|..|. . |||      . .....||. .... || . .. ...|. .|....
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 31-147 2.4e-21 69.7 In-house 24-152 (154) alignment 
Range on Protein: 31-147
Range on HMM: 24-152/154.0
LKQYNITHGVDC----TNLKTKP---IK---GLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQ-QGHN-TVIYCAAGVSRSATLTIVYLMVTENLSLEE
|...||.. ...     || |.    |.    .. ... . |..  .|.. .. . ..|.||     .|  .... .||||||.| | |||   ..|| .
lqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislsl

AYLQVNQVRPIISPNIGFWRQMIDFEKQR
|.  . . |.||.|| || .|.  |||..
alellkdsryiikPnqGflkqleifekel
0043336 (Phosphotyrosine protein) phosphatases II 31-144 1.9e-15 52.5 In-house 108-273 (278) alignment 
Range on Protein: 31-144
Range on HMM: 108-273/278.0
LKQYNITHGVDCTNLK------------------------------------------------TKPIKGLDRIEVPvDDNTLAKITQYFEPVVKYIEDA
......|. |. |.|.                                                .. . ..  . .| |...   ...... . . .|  
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreal

KQQGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFE
. ... ... | |||.|..|. ..||.      . ...||||. .... || . ..  ..|. ....
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_Laforin_pd Subfamily Laforin 45-130 1.2e-06 21.5 In-house 69-154 (183) alignment 
Range on Protein: 45-130
Range on HMM: 69-154/183.0
LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPII
 |    .||  | .|..| .     . .   |  .    ..||   ..| ||| ||...   .|.   . ||     ..   ||..
kklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
0049772 (Phosphotyrosine protein) phosphatases II 49-147 5.1e-25 84.3 In-house 177-273 (314) alignment 
Range on Protein: 49-147
Range on HMM: 177-273/314.0
PIKGLDRIEVPVDDnTLAKITQYFEPVVKYIEDAkQQGHNTVIYCAAGVSRSAT-LTIVYLMVTENLSLEEAYLQVNQVRPiISPNIGFWRQMIDFEKQR
.  |.  . .||.|   | ....|. ....||.| ..|..... |.||..|..| ... |||   ..|||||. .| . || |.|| ||..| ...|.. 
erlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
DUF2088 Domain of unknown function (DUF2088) 50-114 5.3e-06 11.9 Pfam-A 51-116 (204) alignment 
Range on Protein: 50-114
Range on HMM: 51-116/204.0
IKGLDRIEVPVDDNTLAK-ITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENL
.|. ... . |.| |      ............|  .  .  | .| |. |. |   .  .. |..
vkpgekvvivvsDiTRptpskkilpllleelaeagvkdeditilvalGtHraqteeelkkllGeev
PTEN_1 51-148 5.3e-21 70.3 In-house 93-192 (196) alignment 
Range on Protein: 51-148
Range on HMM: 93-192/196.0
KGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQ--QGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRN
.|.  ...|..| .   . . |. ... || ...  .|.. ...|.||..||.|. . ||| ...|. .||   |.. || ..||...... . ......
sgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
subfamily_DSP3_pd Subfamily DSP3 52-146 1.3e-24 80.7 In-house 62-156 (162) alignment 
Range on Protein: 52-146
Range on HMM: 62-156/162.0
GLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGH-NTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIiSPNIGFWRQMIDFEKQ
..  . ..|||.  ... .|||...|.|..| .| .   .. |..|||||||| . |||......| ||  .|.. | |  || || .|.......
eikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldee
0038934 (Phosphotyrosine protein) phosphatases II 52-149 9.6e-16 53.5 In-house 79-178 (194) alignment 
Range on Protein: 52-149
Range on HMM: 79-178/194.0
GLDRIEVPVDDN----TLAKITQYFEPVVKYIedAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
|.. .. |. |     .|. ...... | ...  ....|.  .. | ||..|..|| . ||. . ..|.|||.  ....|| . ||.......  . |. 
gieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel

NG
. 
rk
subfamily_STYXL1_pd Subfamily STYXL1 53-149 5.9e-20 65.1 In-house 59-155 (157) alignment 
Range on Protein: 53-149
Range on HMM: 59-155/157.0
LDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNG
 . ....|.|.  |.. . .. .|..||. |..|.  ...   |.||||.. | |||  ....|..|| .... .. . || .|  |. ..|||  |
akllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
subfamily_Slingshot_pd Subfamily Slingshot 55-144 1.2e-19 64.4 In-house 65-154 (169) alignment 
Range on Protein: 55-144
Range on HMM: 65-154/169.0
RIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFE
 ... | |.  ... .|..   |.|| ||..| . ...|  ||||||.  | | | . .||||||.  |.. | .| || ||..|.  .|
ylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeye
subfamily_DSP23_pd Subfamily DSP23 57-128 6.5e-07 24.1 In-house 56-126 (148) alignment 
Range on Protein: 57-128
Range on HMM: 56-126/148.0
EVPVDDNTLAKITQYfEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
.. .|| .   . |  .  |. .|.|....    ..|. |  |. |.   ||.  ..|.  ||  .| . ||
rlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp
0051299 (Phosphotyrosine protein) phosphatases II 59-134 1.7e-10 36.3 In-house 193-272 (288) alignment 
Range on Protein: 59-134
Range on HMM: 193-272/288.0
PvDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNI
| |...   ...... . . ..  ...|. .|. | |||.|..|. ...|.      .. ....||. .. . || . .. 
p.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 60-147 1.5e-17 57.0 In-house 54-141 (145) alignment 
Range on Protein: 60-147
Range on HMM: 54-141/145.0
VDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
 .|     ..|.|. |  .|.  |..|    ..| |||||| |... .||   |..| ||  ||.  |    ||. | ......||| 
aedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql
PTPc_DSPc_SM00012 61-115 2.4e-07 26.3 In-house 18-68 (105) alignment 
Range on Protein: 61-115
Range on HMM: 18-68/105.0
DDntlAKITQYFEPVVKYIEDAKQqGHNTVIYCAAGVSRSATLTIVYLMVTENLS
.     .|..... | |  ..... ....|. | |||.|..|.. .....  . .
es...dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqlek
subfamily_PTPDC1_pd Subfamily PTPDC1 62-128 8.5e-06 20.3 In-house 92-156 (182) alignment 
Range on Protein: 62-128
Range on HMM: 92-156/182.0
DNTLAKITQYFEpVVKYIEDAKQQGhNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
|   | ... .. .|| .. | |.| .. ..| ||  |   |  .||. ...|. |.|   | . ||
DygvasleriLd.ivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
0048567 (Phosphotyrosine protein) phosphatases II 64-130 9.2e-09 29.9 In-house 52-121 (157) alignment 
Range on Protein: 64-130
Range on HMM: 52-121/157.0
TLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGV---SRSATLTIVYLMVTENLSLEEAYLQVNQVRPII
.|| .....  . |.... . .|.  ...| ||    .|.|||   ||.   ... |||.  . .||| .
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs
subfamily_MSG5_pd Subfamily MSG5 66-149 8e-16 51.6 In-house 79-162 (165) alignment 
Range on Protein: 66-149
Range on HMM: 79-162/165.0
AKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNG
.||.. .  . . |  |. ...  ...|  |.||||.| . |.|   ||||..|| ..  |   |||.||.  |....|   . 
skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalsk
0036941 (Phosphotyrosine protein) phosphatases II 67-145 8.4e-17 56.9 In-house 182-274 (297) alignment 
Range on Protein: 67-145
Range on HMM: 182-274/297.0
KITQYFEPVVKYIEDAKQ------QGHNTVIYCAAGVSRSATLTIVYLM--------VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
.. .........|| ...      .|. ... | |||.||.|. ...||         ...... ||.... . || . .. ...|...... 
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall
subfamily_DSP11_pd Subfamily DSP11 68-127 6.4e-06 20.2 In-house 98-157 (178) alignment 
Range on Protein: 68-127
Range on HMM: 98-157/178.0
ITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVR
.... | | ...|. |....   ..|. || |.  |   ||. .|... |.|  . ...|
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
0046845 (Phosphotyrosine protein) phosphatases II 69-130 2.7e-09 32.3 In-house 184-256 (284) alignment 
Range on Protein: 69-130
Range on HMM: 184-256/284.0
TQYFEPVVKYIEDAKQQ---GHNTVIYCAAGVSRSATLTIVYLMVTE--------NLSLEEAYLQVNQVRPII
.. .   ....... ..   |. .|. | |||.|..|. ...|. .         .....||. .. . ||  
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm
0047943 (Phosphotyrosine protein) phosphatases II 70-142 4.3e-12 41.5 In-house 183-266 (273) alignment 
Range on Protein: 70-142
Range on HMM: 183-266/273.0
QYFEPVVKYIEDAKQ------QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMID
...|.....||....      ... .|. | |||.|..|. ...|.      . .....||. .. . || . ..  ..|....
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0050432 (Phosphotyrosine protein) phosphatases II 70-132 1.5e-09 33.1 In-house 214-283 (308) alignment 
Range on Protein: 70-132
Range on HMM: 214-283/308.0
QYFEPVVKYIEDAKQQ--GHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISP
...|......| ....  |...|. | |||.|..|. ...|.      . .....||. .. . ||   .
pspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq