Gene F13D11.3 in Caenorhabditis elegans

Synonym: CELE_ZK757.2, ZK757.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP058_AA protein Get Run
CeleP058_AA_8-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0036282 (Phosphotyrosine protein) phosphatases II 7-149 4.3e-22 74.1 In-house 8-171 (174) alignment
Range on Protein: 7-149
Range on HMM: 8-171/174.0
ALLSITQVRPHLFLAGYGCITPSLLKQYNITHGVDCTNLKTKP----------------IKGLDRIEVPVDDNTLAKITQyFEPVVKYIEDAKQQ--GHN
  |... . |.|.. ..      .||...||. |.....| .                   |.  . .|..|..   ... .. .||..|.| ..  |. 
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggp

TVIYCAAGVSRSATLTIVYLMVTENL-SLEEAYLQVNQVR---PIISPNIGFWRQMIDFEKQRNG
... | |||.|..|| . ||| .  | ||..|.  | ..|   | . .. ...|.  .|||. .|
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg

subfamily_DSP14_pd Subfamily DSP14 8-157 1.1e-59 194.9 In-house 4-154 (157) alignment
Range on Protein: 8-157
Range on HMM: 4-154/157.0
LLSITQVRPHLFLAGYGCITPSLLKQYNITHGVDCT-NLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
| ...|..|.|||.|.......|||...||. ...| .|.....|...|..|||.||. ||....|..|...||..|..|..|...|.|||||||.|...
laalsqitpsLflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNGNASVELIS
||| .|.|||.||| .|...||||.||.|||.|.||.||. .|..||....
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvd

subfamily_DSP10_pd Subfamily DSP10 9-149 2e-35 116.0 In-house 12-155 (159) alignment
Range on Protein: 9-149
Range on HMM: 12-155/159.0
LSITQVRPHLFLA-GYGCITPSLLKQYNITHGVDCTNLKTKPIK--GLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTI
  ..|| |.|||  . .    ..|...|||. .. |.   .  .  .|    .|| |..  .. ||||  ...||.|...|.. ...| ||.|||||..|
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvi

VYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNG
 |||   ||||..||  |.. |||||||..|  |...|||. | 
aYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk

0044763 (Phosphotyrosine protein) phosphatases II 9-149 2.2e-33 110.8 In-house 21-172 (178) alignment
Range on Protein: 9-149
Range on HMM: 21-172/178.0
LSITQVRPHLFLAGYGCIT-PSLLKQYNITHGVDCTNLKTKPIKGL----------DRIEVPVDDNTLAKITQYFEPVVKYIEDAK-QQGHNTVIYCAAG
. .... |.|.|.....   . |||...||| |..|. .  .  ..            . .|..|..   ....|. .|..||.|  ..|......| ||
inaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSATLTIVYLMVTENLSLEEAYLQVNQVRPiISPNIGFWRQMIDFEKQRNG
|.||.|| . ||| . .||||||. .| ..|| |.|| |..||...||.. ..
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk

subfamily_DSP19_pd Subfamily DSP19 9-147 1.4e-30 100.6 In-house 10-150 (152) alignment
Range on Protein: 9-147
Range on HMM: 10-150/152.0
LSITQVRPHLFLAGYGCI-TPSLLKQYNITHGVDCT-NLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
|....|.|.|.|.      . . ||. .||| .. . ....   | .   .... |.  .....|.. ....||.|...    .. | |||||||.. | 
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
||| .|.||||||. .| ..|| |.|| ||..|. ..|.. 
ylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_DSP8_pd Subfamily DSP8 10-146 5.5e-28 91.5 In-house 14-153 (159) alignment
Range on Protein: 10-146
Range on HMM: 14-153/159.0
SITQVRPHLFLAG-YGCITPSLLKQYNITHGV--DCTNLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
 .|.. ..|.|      .  .||....|.. .  ...  |.. .|    . ||| |.   |. ..|.  |..|. ||..  . .... || |||||. | 
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
|.| | ..||.|||  | . || ||||. |  |....||.
yimktlemsldeayrfvkekrptispnlnflgqLleyeke

PTPc_motif_SM00404 11-145 5e-42 138.1 In-house 2-139 (140) alignment
Range on Protein: 11-145
Range on HMM: 2-139/140.0
ITQVRPHLFLAGYGCIT-PSLLKQYNITHGVDCTNLKTK--PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVY
.... |||.|...  .. | |||...||| ...|. ...    .|  ....|.|||. .|...|.. |...||.|...|.. ...|.|||||||||.|.|
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
|| ...|||.|||  |.. |||||||..|.||.|..||
lmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_DSP1_pd Subfamily DSP1 11-148 2.7e-32 106.1 In-house 18-157 (163) alignment
Range on Protein: 11-148
Range on HMM: 18-157/163.0
ITQVRPHLFLAGY-GCITPSLLKQYNITHGVDCTNLKT-KPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYL
.... ..|.| .       ..||. .||. .....       . .   .....|.. | |...||.|...|...|...    |.|.||.|||.|| ..||
vekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclayl

MVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRN
| |...|||||.  | |.|.|||||.|| .|....||.  
mktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

subfamily_DSP6_pd Subfamily DSP6 11-147 1.8e-29 96.3 In-house 14-154 (158) alignment
Range on Protein: 11-147
Range on HMM: 14-154/158.0
ITQVRPHLFLAG-YGCITPSLLKQYNITHGVDCTNL---KTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
  .. |.|.|     .    .||...| . .. |.    | .  . |   ..|..|.  ......|   ...|..|...  . ...| ||.||| |.|. 
pveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
||| ...|||..||  |.. .. ||||  |  |..|||.. 
ylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl

subfamily_DSP15_pd Subfamily DSP15 11-152 6.3e-28 91.8 In-house 2-144 (151) alignment
Range on Protein: 11-152
Range on HMM: 2-144/151.0
ITQVRPHLFLAGYGC-ITPSLLKQYNITHGVDCTNLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLM
|..| | |.|...       |||. |||| .   . . | .| ..   ....| . ||....|.  |..| ... ...| ...|.||||||.||...|||
iskvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNGNAS
   .|. ..|   ... | .  ||.|| ||. ..||..  .  
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyr

subfamily_DSP12_pd Subfamily DSP12 11-146 6.8e-28 92.0 In-house 2-142 (155) alignment
Range on Protein: 11-146
Range on HMM: 2-142/155.0
ITQVRPHLFLAGYGCITP-SLLKQYNITHGVDCTNLKT---KPI-KGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTI
.... | |.|.|   ..  .|||...||| .  .. .    |.  . ...  ....|.  . | .... .|..||.| ... . .. |.||||||.|. |
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

VYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
 ||| .|.||||.|.  |....| |.|| || .|.  ||| 
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekm

0048076 (Phosphotyrosine protein) phosphatases II 12-147 8e-29 95.6 In-house 5-142 (145) alignment
Range on Protein: 12-147
Range on HMM: 5-142/145.0
TQVRPHLFLAGYGCIT-PSLLKQYNITHGVDCTNLKTKP-IKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLM
... |.|.| .. .     |||...||. ...|. .. .  .|.  . .|..|..   ...... ....||.| ..|......| |||.|..|| . |||
seilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
 ....|||||. .| . ||.. || |..|....||.. 
lllgvsleealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 13-145 1.5e-27 91.5 In-house 6-142 (144) alignment
Range on Protein: 13-145
Range on HMM: 6-142/144.0
QVRPHLFLAGYGCI-TPSLLKQYNITHGVDCTN---LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYL
.. |.|.| .. .     |||...||. ...|.          |.  . .|..|.    ...... ....||.| ..|......| |||.|..|| . ||
eilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaayl

MVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
|....||||||. .| . ||.. || |..|.....||
mkklglsleealalvrsrrpgavpnpgqlrfLleyek

0046846 (Phosphotyrosine protein) phosphatases II 13-147 1.9e-22 75.3 In-house 14-172 (176) alignment
Range on Protein: 13-147
Range on HMM: 14-172/176.0
QVRPHLFLAGYG-----------CITPSLLKQYNITHGVDCTNLKTKPIK------------GLDRIEVPVDDNTLAKItQYFEPVVKYIEDAKQQGHNT
.. ..|.| ..                 .||...||. |..|... .               |.  . .|..|..   . .... ....|..| ..|...
yinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpv

VIYCAAGVSRSATLTIVYLMVT-ENLSLEEAYLQVNQVRP-IISPNIGFWRQMIDFEKQR
.. | ||..|..|| . ||. .  .||.|||. .| ..||  . .. ...|.  .||.. 
lVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll

subfamily_LRR-DSP_pd Subfamily LRR-DSP 14-146 4.1e-24 79.1 In-house 123-257 (263) alignment
Range on Protein: 14-146
Range on HMM: 123-257/263.0
VRPHLFLAGYGCIT-PSLLKQYNITHG-VDCTNLKTKPIKGLDRIEV-PVDDNTLAKITQYFEPVVKYIEDAKQQGHnTVIYCAAGVSRSATLTIVYLMV
. ..||| |  . .  |.||. ..||  .  ....    | .  . .  ..|   |.| |.|| .  .||. ...|   ...| ||||||.||.| ||| 
iidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmk

TENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
 ..| ..||.  | . || | ||.||  |.  .||.
kqrlkfkealdlvikkrpriqPnpGfkdqlkkyekk

0051429 (Phosphotyrosine protein) phosphatases II 14-146 4.1e-17 58.2 In-house 19-223 (272) alignment
Range on Protein: 14-146
Range on HMM: 19-223/272.0
VRPHLFLAGYG-----CITPSLLKQYNITHGVDCTNLK-------TKPIKGLDRIEVPVDDNTLAKITQYF-----------------------------
|.|...... |     .     ||...|.. || ...         . . |.... .|. |..   |....                             
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------EPVVKYIEDAKQqGHNTVIYCAAGVSRSATLTIVYLMVtENLS--------------LEEAYLQVNQVRPIISPNIGFWRQ
                   |.... .|   . |.. .. |.||..|..|.  ..|.. ...|              ||||. .. ..|| . .. .....
arevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

MIDFEKQ
  .....
lyealle

subfamily_STYX_pd Subfamily STYX 16-145 9.2e-19 61.1 In-house 17-155 (166) alignment
Range on Protein: 16-145
Range on HMM: 17-155/166.0
PHLFLAGYGCITPSL---LKQYNITHGV------DCTNLKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIV
| |||  | .   |    ||.  ||| |      ... .| .  . .  . . | |||. .| .|.  | ..|.|. |.| . ...  ||.||||.| | 
pglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalvia

YLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
|.| |  |   ||.. |.. |  |.|| || .|. ..| 
yimetyglkyreafayvqerrfcinpnegfvsqlkeyea

DSPc Dual specificity phosphatase, catalytic domain 18-146 7.1e-39 127.7 Pfam-A 1-133 (133) alignment
Range on Protein: 18-146
Range on HMM: 1-133/133.0
LFLAGYGCITPSLLKQYNITHGVDCTNLKTK----PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTEN
|.|... .....||....||. ...|. ...      .  .....||.|.| .||....| .|..||.|.|.|.. ...|.||.||||||.|.||| |.|
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

LSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
|||.|||  |.. |..||||.||.||....|..
lslneAyefvkerrskispnagflrqLleyerk

DSPc Dual specificity phosphatase, catalytic domain 18-146 7.1e-39 127.7 In-house 1-133 (133) alignment
Range on Protein: 18-146
Range on HMM: 1-133/133.0
LFLAGYGCITPSLLKQYNITHGVDCTNLKTK----PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTEN
|.|... .....||....||. ...|. ...      .  .....||.|.| .||....| .|..||.|.|.|.. ...|.||.||||||.|.||| |.|
lylgskstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktkn

LSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
|||.|||  |.. |..||||.||.||....|..
lslneAyefvkerrskispnagflrqLleyerk

0041856 (Phosphotyrosine protein) phosphatases II 27-150 4.6e-25 83.7 In-house 50-175 (182) alignment
Range on Protein: 27-150
Range on HMM: 50-175/182.0
TPSLLKQYNITHGVDCTNLK----TKPIKGLDRIEVPVDDNTLAKitqyFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQ
   .||...||. |..|.        .  |.  . .|..|..       .. ....||.....|..... | |||.|..|| . ||| . ..|||||. .
flrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavkl

VNQVRP--IISPNIGFWRQMIDFEKQRNGN
|.. ||  .|.|| .|..|.. .|......
vrsrRpgmvitpnqyfflqlallellllkk

0045098 (Phosphotyrosine protein) phosphatases II 28-146 6.5e-23 76.9 In-house 81-270 (278) alignment
Range on Protein: 28-146
Range on HMM: 81-270/278.0
PSLLKQYNITHGVDCTNL--------------------------------------------------KTKPIKGLDRIEV-PVDDNTLAKIT--QYFEP
  .|....||. | .|.|                                                  .. .  |.  .   |..|..    .  ..|  
wrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfle

VVKYIEDAKQ--------------QGHNTVIYCAAGVSRSATLTIVYLMVTE---NLSLEEAYLQVNQVRPI-ISPNIGFWRQMIDFEKQ
....|..| .              .|. ... | |||.|..|| ..||| .    ...|.||. .. . ||. . .| ...|....|. .
llefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle

0037934 (Phosphotyrosine protein) phosphatases II 28-146 3.7e-21 71.3 In-house 65-240 (243) alignment
Range on Protein: 28-146
Range on HMM: 65-240/243.0
PSLLKQYNITHGVDCTNL----------------------------------------------KTKPIKGLDRIEVPVDD----NTLAKITQYFEPVVK
  .|....||. |..|.|                                              .  .  .     .|. |    .. . . .... | .
wrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevre

YIED-----AKQQGHNTVIYCAAGVSRSATLTIVYLMVTE-NLSLEEAYLQVNQVRPI-ISPNIGFWRQMIDFEKQ
.||.     |  .|. ... | |||.|..|| . ||| .  ...||||. .. . ||  . .. ...|. ......
fieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

0051082 (Phosphotyrosine protein) phosphatases II 28-144 4.1e-20 67.4 In-house 26-150 (151) alignment
Range on Protein: 28-144
Range on HMM: 26-150/151.0
PSLLKQYNITHGVDCTNLK-------TKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQ-GHNTVIYCAAGVSRSATLTIVYLMVtENLSLEEA
  |||...|.. |......         |  |.. . .|..|..  .. ..|. |....| . .. .......| ||..|..|| ..|||  ...|||||
lellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

YLQVNQVRP-IISPNIGFWRQMIDFE
. .. . || .. || .|. |.....
leeyrlkrpgvvqpnqqflfqlfall

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 29-146 4.6e-25 81.9 In-house 27-146 (148) alignment
Range on Protein: 29-146
Range on HMM: 27-146/148.0
SLLKQYNITHGVDCTNLKTKPI--KGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQV
. ||. ..|. |..|. . ...  .|.. ..|..||.    . ..||....... ||..|.  .. .  |||||. |....|. ... ||.||.  |.. 
ealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvksk

RPIISPNIGFWRQMIDFEKQ
|. . || || .|. ..|..
rryvdpnlgfLkqLaeleqa

0042113 (Phosphotyrosine protein) phosphatases II 29-146 2.4e-20 68.5 In-house 66-241 (245) alignment
Range on Protein: 29-146
Range on HMM: 66-241/245.0
S----LLKQYNITHGVDCTNLK-----------------------------------------------TKPIKGLDRIEVPVDDNTLAKITQYFEPVVK
     .|....||. |..|..                                                 .. ...    .|..|.. . ...... ...
edfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfle

YIEDAKQ--QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
....| .  ... ... | |||.|..|. ..|||      . ..|||||. .... || . .. ...|........
fvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPMT1_pd Subfamily PTPMT1 29-146 2e-17 58.1 In-house 52-167 (171) alignment
Range on Protein: 29-146
Range on HMM: 52-167/171.0
SLLKQYNITHGVDCTNLKTKPikGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
|| ..|.... ...|.  .|   |.. ..... | | |  ..  |  |..||. ...|.   . | || .||||| . ||| .|.||.|||   ... |.
slneeyelkalansteewkkl..gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk

IISPNIGFWRQMIDFEKQ
||  .   |...  .|..
iirlakkqwkalqeyeek

0043147 (Phosphotyrosine protein) phosphatases II 30-147 2.4e-26 87.9 In-house 39-160 (172) alignment
Range on Protein: 30-147
Range on HMM: 39-160/172.0
LLKQYNITHGVDCTN----LKTKPIKGLDRIEVPVDDNTLAkITQYFEPVVKYIED--AKQQGHNTVIYCAAGVSRSATLTIVYLMVtENLSLEEAYLQV
.||...||| |..|.     .     |.  . .|..|..   ...... ....|..  |...|. ... | |||.|..|| . |||  ..||||||. .|
mlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalv

NQVRPIISPNIGFWRQMIDFEKQR
 . ||....| ...|.  .|||..
rekRpgavqnpsqyrflyyfekll

0049260 (Phosphotyrosine protein) phosphatases II 30-147 9.7e-25 82.4 In-house 28-149 (152) alignment
Range on Protein: 30-147
Range on HMM: 28-149/152.0
LLKQYNITHGVDCTNLKTK----PIKGLDRIEVPVDDNTLAKITQYFEPVVKYIED-AKQQGHNTVIYCAAGVSRSATLTIVYLMVtENLSLEEAYLQVN
.||...||. | .|.|  .      ..   . .|..|..  ...|... ... ||  |...|..... | |||.|..|| . |||   ..|||||. .| 
mlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvr

QVRPIISPNIGFWRQMIDFEKQR
. ||.. || |..|.  .|||..
ekRpgavpnpgqlrflyefekll

0040439 (Phosphotyrosine protein) phosphatases II 30-145 3e-20 68.3 In-house 73-243 (249) alignment
Range on Protein: 30-145
Range on HMM: 73-243/249.0
LLKQYNITHGVDCTNLKT--------------------------------------------KPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQ-
.|....||. |..|.|.                                             .  . .    ... |    .. ..||.....|| ... 
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
     .|. ... | |||.|..|. . |||      . ...||||. .... || . .| ...|. .....
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

0045450 (Phosphotyrosine protein) phosphatases II 30-145 3.8e-20 68.3 In-house 126-301 (307) alignment
Range on Protein: 30-145
Range on HMM: 126-301/307.0
LLKQYNITHGVDCTNLK-----------------------------TKPIKGLDRIEVPVDDN-----------------TLAKITQYFEPVVKYIEDAK
.|.....|. |..|.|.                             ..  .|. .  ..| |.                    .. ..||.... || ..
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

Q------QGHNTVIYCAAGVSRSATLTIVYLMVTEN--------LSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
.      .|. ... | |||.|..|. . ||| .          ..|.||. .. . || . .| ...|. .....
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

subfamily_MKPLT_pd Subfamily MKPLT 30-146 1e-19 64.6 In-house 42-159 (164) alignment
Range on Protein: 30-146
Range on HMM: 42-159/164.0
LLKQYNITHGVDCTN-LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
.||. .||| |  ..  | .  | ..  .| |.|..  ......| . |.. || . |   ...|  |.|||.. |. .|.  .   |.|||  . . | 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

IISPNIGFWRQMIDFEKQ
|..|| || .|.  ||. 
ivapnrGflkqlakfeel

subfamily_MKPLV_pd Subfamily MKPLV 30-146 1e-19 64.6 In-house 42-159 (164) alignment
Range on Protein: 30-146
Range on HMM: 42-159/164.0
LLKQYNITHGVDCTN-LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
.||. .||| |  ..  | .  | ..  .| |.|..  ......| . |.. || . |   ...|  |.|||.. |. .|.  .   |.|||  . . | 
vlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrs

IISPNIGFWRQMIDFEKQ
|..|| || .|.  ||. 
ivapnrGflkqlakfeel

0040438 (Phosphotyrosine protein) phosphatases II 30-145 1e-18 63.1 In-house 105-273 (317) alignment
Range on Protein: 30-145
Range on HMM: 105-273/317.0
LLKQYNITHGVDCTNLKTK----------------------------PIKGLDRIEVPVDDN----------------TLAKITQYFEPVVKYIEDAKQQ
.......|. |  |.|. .                              .|    ...| |.                .  .. ........ .| ....
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
    |. ... | |||.|..|. ..|||      ......|||. .... || . .. ...|...|.. 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydall

0039614 (Phosphotyrosine protein) phosphatases II 30-146 5.7e-18 60.9 In-house 120-287 (297) alignment
Range on Protein: 30-146
Range on HMM: 120-287/297.0
LLKQYNITHGVDCTNLKTKPIKG--------------------------LDR-----------------IEVPVDDNTLAKITQYFEPVVKYIEDAKQ--
.......|. |  |.|. .  |                             .                   ..  |..   .....  .......| .  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQ
 .|. ... | |||.|..|. . |||      . .....||. .... || . .. ...|. .|....
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 31-147 2.4e-21 69.7 In-house 24-152 (154) alignment
Range on Protein: 31-147
Range on HMM: 24-152/154.0
LKQYNITHGVDC----TNLKTKP---IK---GLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQ-QGHN-TVIYCAAGVSRSATLTIVYLMVTENLSLEE
|...||.. ...     || |.    |.    .. ... . |..  .|.. .. . ..|.||     .|  .... .||||||.| | |||   ..|| .
lqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislsl

AYLQVNQVRPIISPNIGFWRQMIDFEKQR
|.  . . |.||.|| || .|.  |||..
alellkdsryiikPnqGflkqleifekel

0043336 (Phosphotyrosine protein) phosphatases II 31-144 1.9e-15 52.5 In-house 108-273 (278) alignment
Range on Protein: 31-144
Range on HMM: 108-273/278.0
LKQYNITHGVDCTNLK------------------------------------------------TKPIKGLDRIEVPvDDNTLAKITQYFEPVVKYIEDA
......|. |. |.|.                                                .. . ..  . .| |...   ...... . . .|  
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavreal

KQQGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFE
. ... ... | |||.|..|. ..||.      . ...||||. .... || . ..  ..|. ....
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

subfamily_Laforin_pd Subfamily Laforin 45-130 1.2e-06 21.5 In-house 69-154 (183) alignment
Range on Protein: 45-130
Range on HMM: 69-154/183.0
LKTKPIKGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPII
 |    .||  | .|..| .     . .   |  .    ..||   ..| ||| ||...   .|.   . ||     ..   ||..
kklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv

0049772 (Phosphotyrosine protein) phosphatases II 49-147 5.1e-25 84.3 In-house 177-273 (314) alignment
Range on Protein: 49-147
Range on HMM: 177-273/314.0
PIKGLDRIEVPVDDnTLAKITQYFEPVVKYIEDAkQQGHNTVIYCAAGVSRSAT-LTIVYLMVTENLSLEEAYLQVNQVRPiISPNIGFWRQMIDFEKQR
.  |.  . .||.|   | ....|. ....||.| ..|..... |.||..|..| ... |||   ..|||||. .| . || |.|| ||..| ...|.. 
erlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil





DUF2088 Domain of unknown function (DUF2088) 50-114 5.3e-06 11.9 Pfam-A 51-116 (204) alignment
Range on Protein: 50-114
Range on HMM: 51-116/204.0
IKGLDRIEVPVDDNTLAK-ITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENL
.|. ... . |.| |      ............|  .  .  | .| |. |. |   .  .. |..
vkpgekvvivvsDiTRptpskkilpllleelaeagvkdeditilvalGtHraqteeelkkllGeev

PTEN_1 51-148 5.3e-21 70.3 In-house 93-192 (196) alignment
Range on Protein: 51-148
Range on HMM: 93-192/196.0
KGLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQ--QGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRN
.|.  ...|..| .   . . |. ... || ...  .|.. ...|.||..||.|. . ||| ...|. .||   |.. || ..||...... . ......
sgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell





subfamily_DSP3_pd Subfamily DSP3 52-146 1.3e-24 80.7 In-house 62-156 (162) alignment
Range on Protein: 52-146
Range on HMM: 62-156/162.0
GLDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGH-NTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIiSPNIGFWRQMIDFEKQ
..  . ..|||.  ... .|||...|.|..| .| .   .. |..|||||||| . |||......| ||  .|.. | |  || || .|.......
eikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldee

0038934 (Phosphotyrosine protein) phosphatases II 52-149 9.6e-16 53.5 In-house 79-178 (194) alignment
Range on Protein: 52-149
Range on HMM: 79-178/194.0
GLDRIEVPVDDN----TLAKITQYFEPVVKYIedAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
|.. .. |. |     .|. ...... | ...  ....|.  .. | ||..|..|| . ||. . ..|.|||.  ....|| . ||.......  . |. 
gieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel

NG
. 
rk

subfamily_STYXL1_pd Subfamily STYXL1 53-149 5.9e-20 65.1 In-house 59-155 (157) alignment
Range on Protein: 53-149
Range on HMM: 59-155/157.0
LDRIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNG
 . ....|.|.  |.. . .. .|..||. |..|.  ...   |.||||.. | |||  ....|..|| .... .. . || .|  |. ..|||  |
akllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg

subfamily_Slingshot_pd Subfamily Slingshot 55-144 1.2e-19 64.4 In-house 65-154 (169) alignment
Range on Protein: 55-144
Range on HMM: 65-154/169.0
RIEVPVDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFE
 ... | |.  ... .|..   |.|| ||..| . ...|  ||||||.  | | | . .||||||.  |.. | .| || ||..|.  .|
ylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeye

subfamily_DSP23_pd Subfamily DSP23 57-128 6.5e-07 24.1 In-house 56-126 (148) alignment
Range on Protein: 57-128
Range on HMM: 56-126/148.0
EVPVDDNTLAKITQYfEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
.. .|| .   . |  .  |. .|.|....    ..|. |  |. |.   ||.  ..|.  ||  .| . ||
rlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp

0051299 (Phosphotyrosine protein) phosphatases II 59-134 1.7e-10 36.3 In-house 193-272 (288) alignment
Range on Protein: 59-134
Range on HMM: 193-272/288.0
PvDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNI
| |...   ...... . . ..  ...|. .|. | |||.|..|. ...|.      .. ....||. .. . || . .. 
p.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 60-147 1.5e-17 57.0 In-house 54-141 (145) alignment
Range on Protein: 60-147
Range on HMM: 54-141/145.0
VDDNTLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQR
 .|     ..|.|. |  .|.  |..|    ..| |||||| |... .||   |..| ||  ||.  |    ||. | ......||| 
aedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekql

PTPc_DSPc_SM00012 61-115 2.4e-07 26.3 In-house 18-68 (105) alignment
Range on Protein: 61-115
Range on HMM: 18-68/105.0
DDntlAKITQYFEPVVKYIEDAKQqGHNTVIYCAAGVSRSATLTIVYLMVTENLS
.     .|..... | |  ..... ....|. | |||.|..|.. .....  . .
es...dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqlek

subfamily_PTPDC1_pd Subfamily PTPDC1 62-128 8.5e-06 20.3 In-house 92-156 (182) alignment
Range on Protein: 62-128
Range on HMM: 92-156/182.0
DNTLAKITQYFEpVVKYIEDAKQQGhNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRP
|   | ... .. .|| .. | |.| .. ..| ||  |   |  .||. ...|. |.|   | . ||
DygvasleriLd.ivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp

0048567 (Phosphotyrosine protein) phosphatases II 64-130 9.2e-09 29.9 In-house 52-121 (157) alignment
Range on Protein: 64-130
Range on HMM: 52-121/157.0
TLAKITQYFEPVVKYIEDAKQQGHNTVIYCAAGV---SRSATLTIVYLMVTENLSLEEAYLQVNQVRPII
.|| .....  . |.... . .|.  ...| ||    .|.|||   ||.   ... |||.  . .||| .
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs

subfamily_MSG5_pd Subfamily MSG5 66-149 8e-16 51.6 In-house 79-162 (165) alignment
Range on Protein: 66-149
Range on HMM: 79-162/165.0
AKITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEKQRNG
.||.. .  . . |  |. ...  ...|  |.||||.| . |.|   ||||..|| ..  |   |||.||.  |....|   . 
skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalsk

0036941 (Phosphotyrosine protein) phosphatases II 67-145 8.4e-17 56.9 In-house 182-274 (297) alignment
Range on Protein: 67-145
Range on HMM: 182-274/297.0
KITQYFEPVVKYIEDAKQ------QGHNTVIYCAAGVSRSATLTIVYLM--------VTENLSLEEAYLQVNQVRPIISPNIGFWRQMIDFEK
.. .........|| ...      .|. ... | |||.||.|. ...||         ...... ||.... . || . .. ...|...... 
gvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

subfamily_DSP11_pd Subfamily DSP11 68-127 6.4e-06 20.2 In-house 98-157 (178) alignment
Range on Protein: 68-127
Range on HMM: 98-157/178.0
ITQYFEPVVKYIEDAKQQGHNTVIYCAAGVSRSATLTIVYLMVTENLSLEEAYLQVNQVR
.... | | ...|. |....   ..|. || |.  |   ||. .|... |.|  . ...|
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear

0046845 (Phosphotyrosine protein) phosphatases II 69-130 2.7e-09 32.3 In-house 184-256 (284) alignment
Range on Protein: 69-130
Range on HMM: 184-256/284.0
TQYFEPVVKYIEDAKQQ---GHNTVIYCAAGVSRSATLTIVYLMVTE--------NLSLEEAYLQVNQVRPII
.. .   ....... ..   |. .|. | |||.|..|. ...|. .         .....||. .. . ||  
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgm

0047943 (Phosphotyrosine protein) phosphatases II 70-142 4.3e-12 41.5 In-house 183-266 (273) alignment
Range on Protein: 70-142
Range on HMM: 183-266/273.0
QYFEPVVKYIEDAKQ------QGHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISPNIGFWRQMID
...|.....||....      ... .|. | |||.|..|. ...|.      . .....||. .. . || . ..  ..|....
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye

0050432 (Phosphotyrosine protein) phosphatases II 70-132 1.5e-09 33.1 In-house 214-283 (308) alignment
Range on Protein: 70-132
Range on HMM: 214-283/308.0
QYFEPVVKYIEDAKQQ--GHNTVIYCAAGVSRSATLTIVYLM-----VTENLSLEEAYLQVNQVRPIISP
...|......| ....  |...|. | |||.|..|. ...|.      . .....||. .. . ||   .
pspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq