Gene F25H5.7 in Caenorhabditis elegans

Synonym: CELE_F25H5.7, F25H5.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf15
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP069_AA protein Get Run
CeleP069_AA_166-444 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 167-438 3.4e-73 242.0 In-house 21-289 (297) alignment 
Range on Protein: 167-438
Range on HMM: 21-289/297.0
WAFKAAKMKCQAISKLHQDKIKGYMPPnCTYTAYDANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWH
....  |...  . .|.  ... . |. .....  .| |.||| |. . . .||.||      .| |||.||.. .. . . ..| ||||||||. |||.
lllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MIYQEKIAYVLMLCTLFEGGVeKCALYYPEKLGevvKFGKYEITLTECKEeaIAGTIWNALTVTNtedaSSEPLYMNHVQVPWWPDQLAPEDARPMIELY
|...... ...||..|.| |. ||| |.||. |   ..|.. .||.....   .| ..  |.|||    ..|.....|.|.. |||  .|.... ..|..
mvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslelllefl

KWVKKVNP---KETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
..|....    |..|..||||||||||.||......  .. .. .. .|..|.|.| .| .|||.  |. ||| .|.|..
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 167-439 1.8e-51 170.0 In-house 6-278 (307) alignment 
Range on Protein: 167-439
Range on HMM: 6-278/307.0
WAFKAAKMKCQAISKLHQdKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNH--DRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIY
|  .. ..  ||.    . ..  . |   |  |..||.| ||| ||.|.. .|.|.| .    ||||| .. .  |    .| .|||| .|  .|| |. 
wvqrtldkgvqalvdefr.vlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp.kkficaqgplentqysfwamai

QEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLT--ECKEEAIAGTiWNALTVTNTE-DASSEPLYMNHVQVPWWPDQLAPEDARPMIELy
|||.  |.||| . | .  ||  |.| . |.   ||.   |..  .   . .|    . . ||. . | ...   ..|.|   |||. .|.     |.| 
qekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapd.edlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl.

kwVKKVNPKETPICVHCSAGVGRTATFVGIDYATIRIMENPNI-EMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
  .. |. .. |. |||||||||. | |.| .   ....  |  .| ..|.|.|. |  |.|. .|.|.|. ||.|||.
..leavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 168-438 3.1e-59 195.0 In-house 18-283 (290) alignment 
Range on Protein: 168-438
Range on HMM: 18-283/290.0
AFKAAKMKCQAISKLHQDKIKGYMPPNC-TYTAYDANP--DLNRYADVRCIEETRVVLKN-HDRDYIHASWMRmpGKdQSTYITTQGPLPETLSDFWHMI
| ...|.. . ..| . .|.| |.| .      .|.|.    ||| || | . |||.||. .| ||.|| ...  |  ....| |||.| .|  |.| |.
asdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk..Gl.kamfiltqGalkdtvidiwrmv

YQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEeAIAGTIWNALTVTNTEDASSEPLYmnHVQVPWWPDQLAPEDARPMIELYKW
 |||.|.. ||| |.| |  ||. ||||| |||. ||.. .. .| ..   | .| . |.| . ..  .  |.  |...  |||.  .  .  .. . . 
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseedd.kdaniikktlsvrdkdsGkehklk..hlkikswpdksvalstlallrtlri

VKKVnpkETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
..|.     |. ||||||.||| ||| |. .   ...  ....||.|| .|  | ..||  .|.| |  .|... 
lrka...sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 169-453 2.5e-210 691.1 In-house 1-285 (285) alignment 
Range on Protein: 169-453
Range on HMM: 1-285/285.0
FKAAKMKCQAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKI
||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fkaakmkcqaisklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqeki

AYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
||||||||||||||||||||||||||||||||||||||||||||||||||.|||||.|||||||||||||||||||||||||||||||||||||||||||
ayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn

PKETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERTGRVDTF
|||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|||
pkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvvertgqidtf
0036941 (Phosphotyrosine protein) phosphatases II 169-445 3.3e-80 264.9 In-house 5-284 (297) alignment 
Range on Protein: 169-445
Range on HMM: 5-284/297.0
FKAAKMKCQAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKI
..  ..  . ..| ...  . . ......... .| ..||| |. . . |||.|.. . |||.||.. ... ..  .| ||||||.|. |||.|......
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnv

AYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTIWNALTVTNTedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
  ..||..|.| | |||| |.|.. ||....|.. .||.....   .. ..  |.||.|   ..|.....| ... |||  .||...........|.||.
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvl

P---KETPICVHCSAGVGRTATFVGIDYATIRIM---ENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVE
.   ...|..|||||||||..||...|..  ..    ..... .|..|...| .|..|||. .|..||| .|.|..    ..|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 169-279 3.2e-08 27.4 In-house 3-112 (332) alignment 
Range on Protein: 169-279
Range on HMM: 3-112/332.0
FKAAKMKCQAIskLHQDKIKGYMPPNcTYTAYDANPDLNRYADVRCIEETRVVLKNHD--RDYIHASWMRMPGKdQSTYITTQGPLPE-TLSDFWHMIYQ
|||  ..   .  | | .      || ||  .  | |.||   . |.. .|| |  .|   |.  |||.    | .|.|| .| |. . |   ||.|. .
fkavtvegpel..lnqmhtsamtypn.tydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgysk.ksayifaqapfndhteyvfwrmvse

EKIAYVLMLCTLFE
 | . .|..  . |
rkpsmilvfgdide
0050432 (Phosphotyrosine protein) phosphatases II 172-438 2.5e-79 262.1 In-house 37-299 (308) alignment 
Range on Protein: 172-438
Range on HMM: 37-299/308.0
AKMKCQAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLkNHDRDYIHASWMRMPG-KDQSTYITTQGPLPETLSDFWHMIYQEKIAY
 ..  . ... ...  . . ........  .| |.||| |. . . .||.| ... |||.||.....  | . ..| ||||||.|. |||.|...... .
kaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

VLMLCTLFEGGVEKCALYYPEKLG-EVVKFGKYEITLTECKEeaIAGTIWNALTVTNTEDAssEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNp
. ||..|.| |.|||| |.|..|| .....||. .||.....   .. .   |..||..|   | ....| . . |||. .|............|.|.. 
IvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrksl.

KETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.. ||.||||||||||.||. .|..  .. .. .. ....|. .| .| ..||. .|.|||| .|.||.
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0040438 (Phosphotyrosine protein) phosphatases II 173-438 1.7e-77 256.2 In-house 14-276 (317) alignment 
Range on Protein: 173-438
Range on HMM: 14-276/317.0
KMKCQAISKLHQDkIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKI
|. ..|... ..| .  . ......... .|.|.||| |. . . .||.|.. .     |||.||.. .| . .  .| ||||||.|. |||.|......
ksdftalleefed.llslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgv

AYVLMLCTLFEGGVEKCALYYPEklGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNTedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
 ...||..|.| |.|||| |.|.  ||....|.. .||....|   || ..  |.|...   .||.....| . ..|||. .|.. ...... ..|....
tvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreal

PK-ETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.. ..|..||||||||||.||......  .. .. .. . ..|.|.|..| .|||. .|. ||| .|.||.
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 173-438 6.2e-71 234.4 In-house 15-277 (278) alignment 
Range on Protein: 173-438
Range on HMM: 15-277/278.0
KMKCQAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKI
....... .|.  ..  . ......... .| |.||| |. . . .||.|.. .     |||.||.. .. . . ..| ||||||||. |||.|......
llnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynv.prkfiatqgPlpetvedFwrmvwelgv

AYVLMLCTLFEGGVEKCALYYPeklGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNteDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
  ..||..|.| |..||| |.|   |.....|.. .||.....   .. .   |.|||    ..|... .|.. . |||. .||.  ......|.|....
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

P-KETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
. ...|..||||||||||.||......  ... . .. ....|.|.| .|..|||. .|. ||| .|.||.
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 174-279 1.1e-15 52.0 In-house 8-118 (347) alignment 
Range on Protein: 174-279
Range on HMM: 8-118/347.0
MKCQAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHD---------RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIY
.|  ..|   .... .| |...|.. .. . . ||  ||. |..|||||   .           || || ...  . .  || || |||.|. |||.|..
ikeaslstyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd.naskeyiltqyplpdtvrdfwkmvs

QEKIAYVLmlcTLFE
  |.. |.   |.||
vtkvtqvv...tife
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 175-466 5.8e-35 115.5 In-house 17-305 (312) alignment 
Range on Protein: 175-466
Range on HMM: 17-305/312.0
KCQAISKlhQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLML
  | ..|  . |  | . ..   ||.    ||||| ...| .  |  |   .  |||| ....  | .  ...||||| .| . ||..      . ...|
tpqqltk..eykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkpe.rfvctqgplentcthfwqlalslgstsiill

CTLFEGGVEKCALYYPEKLGeVVKFGKYEITLTECKEEAIAGTIWNALTVT---NTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKvnpKE
|.. | | |||| |  . .|  |..  . .    | |  | |   . .|         |. .   .|| |   |||.  |.       |   |||     
cgfvedgsekcakyisdivg.fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...dk

TPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERTGRVD-TFMTQYKKHAQKKLA
 |.  ||||||||| |.. |.     .    . .. |.   .|  | ..|.   |...   ...|..  .|. .|  .    |   | |   ||| 
kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyakikakklk
0051299 (Phosphotyrosine protein) phosphatases II 177-438 3.2e-75 248.6 In-house 23-286 (288) alignment 
Range on Protein: 177-438
Range on HMM: 23-286/288.0
QAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVL
  . . ... .. ........... .| . ||| |. . . .||.|..    .. |||.||..... ...  .| ||||||.|..|||.|...... .. 
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIv

MLCTLFEGGVEKCALYYPEklGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNT--EDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-
||..|.| |.|||| |.|.  |.....|.. .||.....   .. ..  |.|||.   | ..|... .| ... |||. .|............|.|... 
mltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

KETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.. |..||||||||||.||. .|..  .. ..  ...|..|. .| .|...||. .|..|.| .|.||.
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 177-438 6.1e-74 244.2 In-house 12-272 (273) alignment 
Range on Protein: 177-438
Range on HMM: 12-272/273.0
QAISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCT
. . . ... .. . . ....... .| |.||| |. . . .||.|.. . |||.||..... . .  .| ||||||.|. |||.|...... .. ||..
tllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLte

LFEGGVEKCALYYPEKLGE-VVKFGKYEITLTECKEeaIAGTIWNALTVTNTEdaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP---KET
|.| | |||| |.|.. || ....||. .||.....   .. ..  |..||..  ..|.....|.... |||. .|..  ...|....|.|..    ...
lvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

PICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|..||||||||||.||. .|..  .. .. .. .|..|. .| .|. .||.  |..||| .|.||.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 177-439 8.2e-45 148.0 In-house 19-272 (288) alignment 
Range on Protein: 177-439
Range on HMM: 19-272/288.0
QAISKLHQDKIKGymPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRmPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCT
... | ..|  ..   .. . ... |||  .|| .. . . ||| |..    ||.|  .   .| .   | .| ||  |.  .|.|. .. . |..||| 
eglkkeyrdspne..asidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlce

LFEGGVEKCALYYPEKLGEVVKFGKYeITLTECKEEAIAGTIWnaLTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVkkvNPKETPICV
| | | || | |.| |||| ...|..  | .  | . |  ..   ... . .    |. .. .. .  |.|.  ||.  . . | . .   .  . || |
llekGkeksaeyfPsklGekarigrl.ctvvkkkradidklvk..vsllriskegeekvivkilhlleWdddgvPenylsplrllevl...kslqkPivv

HCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
|.|||||||.|.. |  |   .  . .. .  .. ..|. ||.|.|. ||.|... ...|...
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0045098 (Phosphotyrosine protein) phosphatases II 179-438 1.6e-72 239.5 In-house 9-272 (278) alignment 
Range on Protein: 179-438
Range on HMM: 9-272/278.0
ISKLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVlknhdrDYIHASWMRMPgkdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLF
..  .. ..  . |  .|.  |  | |.||| |. ... .||.      |||.||.....   . ..| ||||||.|..|||.|.....| ...||..|.
lllefefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EGGVEKCALYYPEklGEVVKFGKYEITLTECKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDA--RPMIELYKWVKKVNP-------
|.|.|||| |.||  |... .|....||.....     ...  .| ...|... |.....|.. ..|||  .|..   ....||........        
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------KETPICVHCSAGVGRTATFVGIDYATIRImeNPNIEMLDIVREMRAMRFQ-AVQSHMQFLFLYVVLMEYF
       ...|. ||||||||||.|.|....   ..  .... .|..|.|.| .| . |||. .|. ||| .|.|..
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 181-445 6.1e-33 108.7 In-house 25-286 (303) alignment 
Range on Protein: 181-445
Range on HMM: 25-286/303.0
KLHQDKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKnhDRDYIHASWMRMPGkdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEG
  . .|. .|.||. .   .  | | ||..|| |.. ..| |   |  |||||.. .    .   | || ||. | .||| || ..|.  ||.| |  | 
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasylelds..skkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GVEKCALYYPEKlGEVVKFGKYEITLTECKEEAI-AGTIWNALTVTNTEdaSSEPLYMNHVQVpwWPDQLAPEDARP-----MIELYKWVKKVNPKETPI
        .|..  . .|| .  | . | |.  .  |   . |.|.| .      |.. | .   || .  | |. |     . .|   ..|  . . ..
dklggdsvfprn.qdflkfeersirvgefkrvelgdgwvlkvlsvsngd..yksflhvhhyka..wphnsipsdgspkfvkqiwqlqsvlrkysdstptv

CVhCSAGVGRTATFVGIDYATIRIM-ENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVE
 .   .|.||. ||  .. | . .  |.. ....  .  .|  |..|||   || ..| .| |. ...|...
ym.slsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngick
0045450 (Phosphotyrosine protein) phosphatases II 184-439 1.3e-71 237.1 In-house 23-305 (307) alignment 
Range on Protein: 184-439
Range on HMM: 23-305/307.0
QDKIKGYM-------------PPNCTYTAYDANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPGK-------DQSTYITTQGPLPETLSD
.| . |.              . ....... .| |.||| |. . . |||.|..     .| |||.||..|.|          . ..| ||||||||. |
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNTeDASSEPLYMNHVQVPWWPDQLAPEDARPMI
||.|...... ...||..|.| | |||| |.|.. ||.. .|.. .||.. ..   .| ..  |.||.. | ..|... .| . . |||. .|..  ...
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeell

ELYKWVKKVNP---KETPICVHCSAGVGRTATFVGIDYATIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
.... |.|..    |..|..||||||||||.||......  .. ...    . .|..|...|..| .|||.  |. ||| .|.|.. 
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 184-439 3.8e-29 96.4 In-house 26-280 (439) alignment 
Range on Protein: 184-439
Range on HMM: 26-280/439.0
QDKIKGYMPP---NCTYTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCT
 .||.   |.   ... .| . .   ||| ||   . |||.|..        || | ...    |.  ||.||||  ||  ||| .....| . ..||. 
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkkettddfwrlviekktvtivmltn

LFEGGVekcalYYPEKlgEVVKFGKYEITltECKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE--TPI
|.|        |.| .  . | .|   .     ..  .   .   . | |  | .     . ...   |||.  | .|  .... . ..  | ||   |.
lvesyk.....ywpsd..aevcygdiavr..vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpv

CVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
 |||||||||| | . .| |  ..  . ....  ||. .|  | | ||.  |..|.|  ..|  .
vvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 185-442 7.6e-39 128.1 In-house 34-294 (310) alignment 
Range on Protein: 185-442
Range on HMM: 34-294/310.0
DKIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLK---NHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGG
 |.     .  || ||  .   |||.|| | ...|| ||       ||||| ...     .||.| .||||  |. ||| ||.||.   .|.||   | |
rkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktn.ylrstficsqgplqhtiidfwrmifqeraesilllckvgeeg

VEKCALYYPeKLGEVVKFGKYEIT-LTECKEEA----IAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIElYKWVKKVnpKETPICV
  ||  |.|  ||    .|   .| |.|  ||     .| |.       . . |  . | .. .. | |||.  |..    .   . . .|  .  |  |
rpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv..rhgpcvv

HCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEG
|||||..|. . | ....  .. .  .... ... |..  |.. .|...|.|..  | . .  || 
hcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarget
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 186-438 1.9e-29 97.4 In-house 23-293 (301) alignment 
Range on Protein: 186-438
Range on HMM: 23-293/301.0
KIKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNH------DRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFE
..| . . .|| .  ..|  |||. ..  ... |..||..       |.|| ||..    ...  .| .|||. .|| |||..|.||| . ..|.. | |
elkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy.sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke

GGVEKCALYYPEKLGEVVKFGKYEITLTECK------EEAIAGTIWNALT----VTNTEDAS-SEPLYMNHVQVPWWPDQLA-PEDARPMIELYKWVK-K
|  .||  |.|.   |  .||. ..||.. .         .. .| ..        . .  |  ..  .  .||  ||..   .| .  .  . . .. .
gtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrq

VNPKETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
  .   |. ||||..|.|. ... .. .      .  ... .... .|  .  ||.   |. ..| |. .|.
qkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
DSPc_SM00195 187-438 4.1e-75 247.9 In-house 10-262 (263) alignment 
Range on Protein: 187-438
Range on HMM: 10-262/263.0
IKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
 . . | ..| .. ..| . ||| .. ....||| ||. .     |||.|...... . ...|| ||||||.|..|||.|...||. ...||.  .| | 
eestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

EKCALYYPEKLGEVVKFGKYEITLTECKEEAiAGTIWNALTVTNTEDasSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KETPICVHCSAG
|||. |.||. |.  .|||....|.|....  . .|   |..|....  .|.  ....|.  |||. .|.......||.. ||| .  ...||.||||||
ekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

VGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||||.||| ||..  .. |. .... .||.|.|  |...||...|.||.| ...||.
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 187-438 4.1e-75 247.9 In-house 10-262 (263) alignment 
Range on Protein: 187-438
Range on HMM: 10-262/263.0
IKGYMPPNCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
 . . | ..| .. ..| . ||| .. ....||| ||. .     |||.|...... . ...|| ||||||.|..|||.|...||. ...||.  .| | 
eestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

EKCALYYPEKLGEVVKFGKYEITLTECKEEAiAGTIWNALTVTNTEDasSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KETPICVHCSAG
|||. |.||. |.  .|||....|.|....  . .|   |..|....  .|.  ....|.  |||. .|.......||.. ||| .  ...||.||||||
ekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

VGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||||.||| ||..  .. |. .... .||.|.|  |...||...|.||.| ...||.
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 190-439 7.1e-43 141.4 In-house 36-290 (305) alignment 
Range on Protein: 190-439
Range on HMM: 36-290/305.0
YMPPNCTYTAYDAN------PDLNRYADVRCIEETRVVLKN-HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
|  |. | .|..||         |||.|| | ... | |..    ||||| ..  |   .  .| .|||| .|. .|| |. |.|.  ..|||   | | 
ytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgk

EKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKkvnPKETPICVHCSAGV
 ||| |.|   || ...    .         .       .|. |   . .. . . |.|   |||.  |      .||   ..     . || ||||||.
lkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gskvpivvhcsagi

GRTATFVGIDYATIRIMENPNI-EMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
||| | | |.|   .| || .   | ..|. .|  |  ..|. .|.||.. |...||.
grtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_CG7180_pd Subfamily CG7180 190-439 2.1e-31 103.7 In-house 29-291 (296) alignment 
Range on Protein: 190-439
Range on HMM: 29-291/296.0
YMPPNCTYTAYDANPDLNRYADVRCIEETRVVLK----NHDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVeKC
    .|       | . ||. .|   . .||||.    ... ||| |...    |..  || |..|  ||. .|| ..|.|.|  | .|.  |.    ..
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk.eyivteapkketvdefWrlvydeeisavvvLtktfdfak.my

ALYYPEKLgeVVKFGKYEITLTECKEEAIAGTIWNALTVT------NTEDASSEPLYMNHVQVPWWPD-QLAPEDARPMIELYK----WVKKV--NPKET
  |.|.|     ..|. .. ..| |. |   .    || .      .... . |   . ..|.  |.  .  |  .  .||| .    |..||  .|.| 
psywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
|..|..| |..|.  ...|| .   . .. .... . |. .|  | | |..  .. ..| || |...
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Ptp69D_pd Subfamily Ptp69D 191-439 4.8e-44 145.7 In-house 36-287 (307) alignment 
Range on Protein: 191-439
Range on HMM: 36-287/307.0
MPPNCTYTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCA
.. ... .. . |   ||| |..  ..|||.||.    .| ||| ||...   |.. ..|. |.|. .|. ||| || . ..  . ||  | |   .|||
idkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikg.ykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkca

LYYPEKlgEVVKFGkyEITLTECKEEAIAGTIWNALTVTNTEDASS---EPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKV-NPKETPICVHCSAGV
 |.|.   . |..|  .|  .  .||     |  .| |..... |.   .   .   .   |.|  .|| || ...| . |... . ...|| |||||||
kYWpie..devqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGv

GRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
||...|| .|    .. .. .... ..|...|  |   |||  |. |||  |..|  
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0046845 (Phosphotyrosine protein) phosphatases II 192-438 7.8e-75 247.2 In-house 17-274 (284) alignment 
Range on Protein: 192-438
Range on HMM: 17-274/284.0
PPNCTYTAYDANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPG----KDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
  ....... .| ..||| |. . . .||.||.     .| |||.||......    . . ..| ||||||.|. |||.|...... .. ||..|.| |.
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

EKCALYYPEKlGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNTeDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK---ETPICVHCS
|||| |.|.. |||...|.. .||.....    . .   |..||. . ..|.....| ... |||. .|.......|....|......   . ||.||||
ekcaqYwple.gevltygdftvtllseev..kddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGVGRTATFVGIDYATIRIMENP---NIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||||||.||. .|..  .. ..    .. .|..|. .| .|...||. .|..|.| .|.||.
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 192-438 1.1e-36 121.0 In-house 25-269 (281) alignment 
Range on Protein: 192-438
Range on HMM: 25-269/281.0
PP-NCTYTAYDANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKC
|   ||      |   |||... |.. .|| ||         ||||| ..| |      || ||||  || .|||.||.||. . ..||| . |   |||
psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

ALYYPEKLGEVVKFGKYEITLTECkeeaiagTIWNALTVTNTE-DASSEPLYMNHVQVPWWPDQLAPEDARPMIelyKWVKKVNPKETPICVHCSAGVGR
| |.| .   ...| |. ..  .        |. ..|  |  .     |   . |     |||   || .  |.   | ..|.  . ||  .||||||||
aeyfprnahcclqfdklsvsyeds.......tvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevml...kilrkirarstppvihcsagvgr

TATFVGIDYATIRIMENPNI-EMLDIVREMRA-MRFQAVQSHMQFLFLYVVLMEYF
. |.. .. |   |     . .. .||  .|   |  .||.  |..... ||... 
sgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_PTPRD_pd Subfamily PTPRD 193-445 8e-61 201.3 In-house 38-287 (564) alignment 
Range on Protein: 193-445
Range on HMM: 38-287/564.0
PNCTYTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALY
 ...  ...||   ||||..   ...||||..    .. ||| ||..      . .|| |||||.||..||| |....... . ||  | | | .||. |
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

YPEKlGeVVKFGKYEITLTECKEeaIAGTIWNALTVTNTEdaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKET-PICVHCSAGVGRTAT
.||| |   ..|....||.|..|  .|  .   .......  |||    .. .   |||. .|| |.....| . |...|.... || |||||||||| |
WPek.g.tetygeltVtleeeee..ladyeirtfklkkkk..ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGt

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGeGVVE
|. ||.   || |. ....  .|...|. |   ||.. |. |.. ...|.    |. |
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac.gnte
0040439 (Phosphotyrosine protein) phosphatases II 194-438 1.9e-66 219.5 In-house 2-246 (249) alignment 
Range on Protein: 194-438
Range on HMM: 2-246/249.0
NCTYTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
..... . .|.|.||| |. . . .||.|.      . |||.||.. ..   .  .| ||||||||..|||.|.....| ...||..|.| | |||| |.
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PEklGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNTedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP---KETPICVHCSAGVGRTA
|.  |.....|.. .||.....   .. .   |..||.    .|... .|.|.. |||. .|..  ........|.|..    |..|..||||||||||.
pl..ggsleygdftvtllsvev..kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||......  .. .. .. ....|...| .|..|||.  |. ||| .|.|..
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN13_pd Subfamily PTPN13 194-436 4.9e-51 168.6 In-house 28-267 (273) alignment 
Range on Protein: 194-436
Range on HMM: 28-267/273.0
NCTYTAYDANPDLNRYADVRCIEETRVVLKNHDRdYIHASWMRMP-GKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEK
.|. .  ..| | ||| .|  ..|||| |...   || ||....| |||. .|| .||||||| .||| |... |   . |. .  |.|  ||  |.||.
tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

LGEVVKFGKyEITLTECKEEAIAGTIWNALTVTNTEdaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVGID
 .. .|     ....  | .   |   .||.|...|  |.|   . |..   |||   |  | ..... . |.... ...|| ||||||.||. |.. ||
knkklkvsn.rlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitid

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 .   |  . .... .|||..|  |   ||.. |..| | ...|
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 194-444 2.2e-42 140.5 In-house 52-298 (319) alignment 
Range on Protein: 194-444
Range on HMM: 52-298/319.0
NCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCtlfeggVEKCALYY
. |..  | | | ||. ..   ....| |.. .     ||| ||..    . .  ||..||||..|| ||| ||.. ... ...|        .||. |.
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy.qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqyw

PEKLgeVVKFGKYEITLTECKEEAIagTIWNALTVTN-TEDASSEPlyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE---TPICVHCSAGVGRT
| |   |.| ..... ..  .| |    .   . ... ..        ..      |||.  |. . ... | | |.... ||   ..| ||||||||||
plki..vikeerfkvkvdsveetae..yvvrdielsedgkekdirk..itqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

ATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME-YFIGEGVV
 ... .|    |. |.  ... ..||..|  | . ||. .|. |.|. |.| ...|   |
Gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 194-444 4.1e-42 139.6 In-house 16-262 (284) alignment 
Range on Protein: 194-444
Range on HMM: 16-262/284.0
NCTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCtlfeggVEKCALYY
. |..  | | | ||. ..   ....| |.. .     ||| ||..    . .  ||.|||||..|| ||| ||.. ... ...|        .||. |.
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy.qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PEKLgeVVKFGKYEITLTECKEEAIagTIWNALTVTN-TEDASSEPlyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE---TPICVHCSAGVGRT
| |   |.| ..... ..  .| .    .   . ... ..        ..      |||.  |. . ... | | |.... ||   ..| ||||||||||
plki..vikeerfkvkvdsveesee..yvvrdielsedgkekdirk..irqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

ATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME-YFIGEGVV
 ... .|    |. |.  ... ..||..|  | . ||. .|. |.|. |.| ...|   |
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
0042113 (Phosphotyrosine protein) phosphatases II 195-438 2.1e-65 215.9 In-house 1-243 (245) alignment 
Range on Protein: 195-438
Range on HMM: 1-243/245.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
...... .|.|.||| |. . . |||.|....     |||.||.. ..   .  .| ||||||||. |||.|.....| ...||....| | .||| |.|
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

EklGEVVKFGKYEITLTECKEeaIAGTIWNALTVTNTedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP--KETPICVHCSAGVGRTATF
.  ||....|.. .||....    .. .   |.|||.   ..|..  .|..   |||. .|.. . .......|.|.    ...|..||||||||||.||
l..gesltygdftvtllseeh..lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
......  .. .. .. . ..|.|.| .| .|||.  |. ||| .|.|..
iaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 195-438 3.2e-60 199.0 In-house 2-242 (243) alignment 
Range on Protein: 195-438
Range on HMM: 2-242/243.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNhdRDYIHASWMRMPGkdqsTYITTQGPLPETLSD----FWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
...  . .| . ||| |. . . .||.|..   |||.|.......    ..| ||||||||. |    ||.|.....| ...||..|.| |.|||| |.|
fsiallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

eklGEVvKFGKYEITLTECKEeaIAGTIWNALTVTNtEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKK---------VNPKETPICVHCSAG
   |||  .|....||.....   .. .   |...|  |.. ....  |..   |||. .|..  ..... ..|..         ..... |..||||||
...gev.tygdftvtllseeh..lddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTATFVGIDYATIRImenpNIEMLDIVREMRAMRFQ-AVQSHMQFLFLYVVLMEYF
||||.|.. ...   ..    .. ....|...|..|.. |||.  |. ||| .|.|..
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 195-439 3.5e-55 182.3 In-house 38-284 (305) alignment 
Range on Protein: 195-439
Range on HMM: 38-284/305.0
CTYTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
.  .  .||   ||....   .. |. |..    .|.||| ||..    | . .||..||||..|..|||..|..||.  ..||. | ||| .||  |.|
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp

EKLGEVVKFGKYEITLTEckEEAIAGTIWNALTVTNTEDaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE--TPICVHCSAGVGRTATF
|. .|...||.....|..  |..... |   |.... .. ..|   . . |.  |||.  |. |  ...|.| |.|   |.  .|. |||||||||| .|
esktekkefgefsvelks..ektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
. .| |  |. .   ... ......|  | ..||.  |. ||. .| |. .
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN9_pd Subfamily PTPN9 195-438 1.3e-51 170.4 In-house 34-290 (297) alignment 
Range on Protein: 195-438
Range on HMM: 34-290/297.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
 ...   ||   |||.|| |..||||||.. |     |||.|...    | . ..|.|||||..| |||| |......  ..|   . | |  ||. |.|
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdG.ykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

EKLGEVVKFGKYEITLTECKEEaiAGTIWNALTVTNTEDASSEplYMNHVQVPWWPDQLAPEDARPMIELYKWVKK--------------VNPKETPICV
.. ... .||.....  | .||       . |...|...  |    . | |.  |||   |..|  .... . |..               .|.. || |
leeessaefgdlsvsnveveee..edykvrvleiknvkteesr..kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|||||.||| ||. .|..  |. |  .... . |. .|. |  ..|   |. | |. ..|| 
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPRA_pd Subfamily PTPRA 195-448 7.3e-47 154.8 In-house 50-306 (330) alignment 
Range on Protein: 195-448
Range on HMM: 50-306/330.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRmPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
.  .. . | . ||. ..   . .||.| .     . ||| ||..    |.. ..|..|||. ||. ||| ||.. | | ..||  | |   |||| |.|
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid.GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

EKlgEVVKFGKYEITLTECKeEAIAGTIWNaLTVTNTEDAS--SEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-TPICVHCSAGVGRTAT
..   .| .|.  ... ... .... |. . . |..  ||.   ..  .. .    |||   | ... |..| | |||.|...  || |||||||||| |
de..GlvtyGnirvevedet.vlvdytvrk.flvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGt

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF-IGEGVVERTG
|. .|    |.  .  ... ..|...|. | | ||. .|. |.| ||.||.  |.  .. . 
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 195-438 2.2e-44 146.6 In-house 39-278 (287) alignment 
Range on Protein: 195-438
Range on HMM: 39-278/287.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
 | .    | |.||....   .. ||.||... ||| |...    |..  .| ...|. .|. .||..| ....  ..||| . |   |.|  |.||.  
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidg.ykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks

evVKFGKYEITLTEckEEAIAGTIWNALTVTNTEDASsEPLYMNHVQVPWWPDQL-APEDARPMIELYKWVK-KVNPKETPICVHCSAGVGRTATFVGID
  | .|.|.|.|..  ||  || |   | |.|.. |. ... ..  |.  |...   .| .  .. . . .| .  . .|.| ||||..|||.|.|. ..
..vvlGeynielln..eevnagyierklevknknkag.dkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaa

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 .  .  ..  |.........|  . ..||   |. |.. ...|| 
ttinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_PTPRG_pd Subfamily PTPRG 195-442 2.6e-44 146.4 In-house 39-291 (563) alignment 
Range on Protein: 195-442
Range on HMM: 39-291/563.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNH-----DRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
.. .    |   ||| ..  ....|| |..      . ||| |...    . .  .|.|||||..|. |||.||.... | . |.  | | | .||  |.
aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy.qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYW

PEklGEVVKFGKYEITLTEckEEAIAGTIWNALTVTNT--EDA--SSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-TPICVHCSAGVGR
|.   |....|. ..||.|  || .|    . |.. |.  ..     . . . . . . |||. .|| . | .   |  .. |..|  || |||||||||
Pk..desetygalqvtlie..eevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgr

TATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEG
| |.. .|  . .| ..  ........ .||.|   ||.. |..||. .|.|   .. 
tGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 195-436 1.1e-43 144.2 In-house 25-264 (283) alignment 
Range on Protein: 195-436
Range on HMM: 25-264/283.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMR--MPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEK
.. .. | |.  ||. ..   .  || ||.. |||| |...      |..  || .|.|| .|  |||.|...|||. ..||  | |.  .||. |.|..
adiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

lGeVVKFGKYEITLTecKEEAIAGTIWNALTVTNTEDASSEPLyMNHVQVPWWpdqLAPEDARPMIEL--YKWVK--KVNPKETPICVHCSAGVGRTATF
 |  ...|.. .||   || .    |   |.. .   | |. | . | ||  |   |  ..  ..  |  .  |.  . . |..|| ||||.|.||||.|
.G.sedyGeftvtlr..kettsnsfiikelllrvnssakstll.lahyqvidW...leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
...  .   .. .  ...  .|. ||  |  |||.  |. ... . .|
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN1_pd Subfamily PTPN1 195-436 2.1e-43 143.1 In-house 24-269 (290) alignment 
Range on Protein: 195-436
Range on HMM: 24-269/290.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
.. .  ..| .|||| ||.  . .|..|...| ||| || . ..   .  || ||||||.| . ||.|....|   |.||  . | .  ||| |.|..  
treaklpenrnlnryrdvspydhsrikleradndyinaslveleea.krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-EVVKFGKYEITLTECKEEAIAGTIWNALTVTNTEDASSEPLYMNHvqVPWWPDQLAPEDARPMIELYKWVKK---VNPKETPICVHCSAGVGRTATFVG
 . ... . .....  .||     . . | ..| .   .  ..  |     |||   ||    ....   |..   ....  |  .|||||.||. ||. 
ekellledtklkvkliseerksyytvrllelenlktqetreilhfh..yttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IDYATIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
.|   ..| .. .   ... . . |.| .|.  .|   |. | |. ..|
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 195-441 6.9e-41 135.3 In-house 43-287 (297) alignment 
Range on Protein: 195-441
Range on HMM: 43-287/297.0
CTYTAYDANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMpgkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVeKCALYYP
 | .    | . .||...  ..  || |.      | ||. ||...     .  .|||| | ..|. ||| |...|... ..||  . |.   ||| |..
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg...nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

EKlgEVVKFGKYEITLTECKEeaIAGTIWNALTVTNTEDASSepLYMNHVQVPWWPDQLAPE--DARPMIELYKWVKKVNP--KETPICVHCSAGVGRTA
.|   |..||.  ..|.  .|    | |   |.||. .  .     ..  |   |||.  ..  .|. ...| . |.|.    .|.|. |||.||||||.
dk..gvttfGdvsvvllsvse..reGfikrelevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

TFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGE
 .. ||    .. .. .......|. .|  | . || . |. |.||...|... |
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_PTPN14_pd Subfamily PTPN14 195-438 3.4e-40 132.9 In-house 41-296 (300) alignment 
Range on Protein: 195-438
Range on HMM: 41-296/300.0
CTYTAYDANPDLNRYADVRCIEETRVVL---KNHDRDYIHASWMRMP-GKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
.. .. . | . ||. ||   |..|| |   |. . .|| || .... |  . .||..||||. |. |||.|....... ..||    |.| ||.  |.|
lstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

EK--LGEVVKFGKYEITlTECKEEAiAGTIWNALTVTNTedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK----------ETPICVHC
..    . |.|||...| |. .|..   .| ..|..      |.|   . |.|   |||.  ||| .....  . |. |  |          . |. |||
kleskkktvefgkfkvt.tkfseds.dsvittglklkhl..pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

SAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|||||||   .  |  .  .  | .|..  ... .|  |   ||.  |. |.| ||..|.
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0049772 (Phosphotyrosine protein) phosphatases II 195-437 2.5e-36 121.4 In-house 38-279 (314) alignment 
Range on Protein: 195-437
Range on HMM: 38-279/314.0
CTYTAYDANPDLNRYADVRCIEeTRVVLKN---HDRDYIHASWMRMPgkdqSTYITTQGPLPETLSDF----------WHMI--YQEKIAYVLM------
..   . .|.| ||| |. . . .||.|..   .. |||.||... .     ..| |||||..|. ||          |.|.  .. .. .. |      
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LCTLFEGGvekcALYYPEKLGEVVkfgkyeitlteckeeaiagtiwnaltvtntED---ASSEPLY-MNHVQVPWWPdQLAPeDA
               |..| ..|    ... .. | .                                |    ..  . . ......|..    || . 
adelsrLdaAlgKtpllildgng....neptaadlellk..............................eelydpelferlgikylripvpD.gsap.ll

RPMIELYKWVKKVnPKETPICVHCSAGVGRTATFVGIDYatirIMENPNIEMLDIVREMRAMRF-----QAVQSHMQFLFLYVVLMEY
. . |........ .|..|. |||.||.|||.||| ..|    .|   .. . ......|..|.      .... .|..| . .|.||
edfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaay....lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_PTPRN_pd Subfamily PTPRN 195-435 4e-32 106.1 In-house 46-289 (297) alignment 
Range on Protein: 195-435
Range on HMM: 46-289/297.0
CT--YTAYDANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALY
.|   .  . | . ||...|   ...|| ||..    . ||| || .      ...||.|||||..|..||| |.... .. ...|..| | ||..|. |
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry

YPEKLGEVvkFGKYEITLTEckEE-AIAGTIWNALTVTNTEDASSEPLYMNHVqvPWWPDQLAPEDARPMIELYKWVKKV-NPKETPICVHCSAGVGRTA
.|..  ||  .. ||. |    |       .  .. . | .   .  .   |     ||.. .|  |....|. . | |    . .|| ||||.|.||| 
wpdeGsev..yhiyevhlvs..ehiwcddylvrsfylknlqtsetrtvtqfhf..lswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtG

TFVGIDYATIRIMEN-PNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLM
... ||    |..    .|..   .  .|  | . |... || | . .. 
vyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 196-438 1.2e-44 147.3 In-house 39-283 (290) alignment 
Range on Protein: 196-438
Range on HMM: 39-283/290.0
TYTAYDANPDLNRYADVRCIEETRVVLK--NHD----RDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
|.     |  |||.|..   .. |..|.  . .     .||.|...    |..  || ||||...|| |||..|.|||.. ..||..  | | .||  |.
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PEKlgEVVKFGKYEITLTecKEEAIAGTIWNALTVTNTEDAsSEPLYMNHVQVPWWPDQL-APEDARPMIELYKWVK-KVNPKETPICVHCSAGVGRTAT
|..  .. ..|...|.|.  .||.. . |   | |.|.. |  ..  . . |.  |...   .. .  .. ... .| .  . .|.| ||||..|||.|.
pds..dtkaygefsikll..neetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsav

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|. .. .  .   .  |.........|  . . ||.  |. ... ....|.
fcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN3_pd Subfamily PTPN3 197-433 8.9e-56 183.8 In-house 35-270 (280) alignment 
Range on Protein: 197-433
Range on HMM: 35-270/280.0
YTAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRM--PGKDQS-TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEkL
 .   .| . ||| |.   ..||| ||. . ||| |... |  |.....  ||.|||||..| .|||.|....|.  ..|| || | |  ||  |.||  
aarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.t

GEVVKFGKYEITLTECkeEAIAGTIWNALTVTNTEDASSEPlyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKETPICVHCSAGVGRTATFVGID
.. ...|.........  ..    .   |.....|   . .  . ..|   |||.  |.|.  ..|. . |.|.   ||.|. ||||||.|||  .. ..
edeleygefsvkceke..detksyvlrelvlkdketkeerk..ilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVV
 |   | .. .. .|||||.||  |   ||.. |. |.   
talalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPRB_pd Subfamily PTPRB 197-438 5.5e-53 174.9 In-house 45-285 (293) alignment 
Range on Protein: 197-438
Range on HMM: 45-285/293.0
YTAYDANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEK
 .   .| . ||| ..   ...|| |    .... ||| |....   . .  .|.||||||||. |||.|....|   ..||  |.|.| .||  |.|..
aaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy.nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad

LGEVvKFGKYEITLTEckEEAIAGTIWNALTVTNtedaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN---PKETPICVHCSAGVGRTATFV
  .|  .|. ..||..  ||     .   |....    ..|   ... .   |||   ||........ . |...     ...|| |||||||||| ||.
eepv.lyGdikvtlva..eeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfi

GIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 .|  . .| |.  .... || |.|  |.. ||.  |..|.. ......
aldrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 197-438 3.7e-48 159.2 In-house 42-283 (319) alignment 
Range on Protein: 197-438
Range on HMM: 42-283/319.0
YTAYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEK
 .  . | . ||| ..  .. |||||..    .. ||| ||..    .... .| ||.|| .|..||| |...|..  |.||. | | .  |.  |.||.
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee

lgEVVKFGKYEITLTEckEEAIAGTIWNALTVtNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK--ETPICVHCSAGVGRTATFVG
  .....|.. .|| |  ||  .. |   |.. |.  .  |   . | |   |||.  ||.|. ...|.| ..|   |  . || |||||||||| ||. 
..nfeeyGrlivtlee..eeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfiv

IDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.| .  |. |.  ...  .|...|. |   || . |. |.| .|.|. 
ldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 198-438 8.9e-54 177.5 In-house 36-276 (281) alignment 
Range on Protein: 198-438
Range on HMM: 36-276/281.0
TAYDANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKL
.  |.|   ||| ..   . |||..    .|.. ||| |...    |..  ||.||||.|..| .||.|....|.  . |.    |.|  ||  |.|.. 
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

GeVVKFGKYEITLTEckEEAIAGTIWNALTVtntEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKET--PICVHCSAGVGRTATFVGI
   .|.|.. .. |.  ||. |  |   ...   |  |.|.  .....   |||. .|.... ..|  | |.|.. |.|  |...||||||||| |....
s.elkygdvtvksta..eeekatyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyial

DYATIRIME-NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
| .  .. . ...... ..|.|.|  |   ||. .|. |.| ......
Drlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN23_pd Subfamily PTPN23 198-436 1.4e-46 153.6 In-house 38-278 (288) alignment 
Range on Protein: 198-436
Range on HMM: 38-278/288.0
TAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVV
..   ... ||. |.   ...||.|...  ||| ||...       ..|.||.||..||.||| |.|..|   . || .  | | .|.. |.||. || |
aiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

KFGKYEITLTECKEEaiAGTIWNALTVTNTEDasSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKK-----VNPKETPICVHCSAGVGRTATFVgID
|||....|| . .|      .   |...  .   ..   . |.|.  ||.  .|.    .... . |..      .. .||. |||||||||| .|  . 
kfgdlsvtlksvret..ethvervlkletlda..davksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa.lv

YATIRIMENPN--IEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
|| .| .|. |  ......|. .|. |   || . |. |.| . .|
yaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 198-440 5.8e-29 95.7 In-house 40-238 (392) alignment 
Range on Protein: 198-440
Range on HMM: 40-238/392.0
TAYDANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGvekcalyypekl
.  . |   ||| ..  ....||.|       |.||. ||...    .  .||..||| . .|.|||.|..||... . |.  | ||             
aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

gevvkfgkyeitlteckeeaiagtiwnaltvtntedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKET-PICVHCSAGVGRTATFVGID
                                       .   .   ..  |||.  |. .  .... | ||    . | |. .|||||||||.  . ||
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
    .  .   ......| ..|  |   ||.. |. |.|  ..| .. 
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 198-438 2e-26 87.1 In-house 46-285 (302) alignment 
Range on Protein: 198-438
Range on HMM: 46-285/302.0
TAYDANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYItTQGPLPETL---SDFWHMIYQEKIAYVLMLCTLFEGGVeKCALYYPEKLG
.|. .|.. |.  ||.......| |...  .|..|| . .|   .|... .| |  ..     .||.|..||||. | .|    |        ..|.| |
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

EVVKFGKYEITLTEckEEAIAGTIwNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWV-KKVNPKETPICVHCSAGVGRTATFVGIDY
. ...||  .       |   ..  .....    .  |. . .|   .  |...  |.    .|.  . | .|  . . .. .    |.|| ..|.    
dykeygkmfvNnrk..Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|  .. .. . .. .||. .|. | .||.|  |. .||..|. |.
aveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_PTPN12_pd Subfamily PTPN12 199-438 2.6e-55 182.3 In-house 36-277 (290) alignment 
Range on Protein: 199-438
Range on HMM: 36-277/290.0
AYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
  . |   ||| |.   ...||.|..    .. ||| |.... . . . .|| .|||||.||.|||.||.. ..  |.|.| ..| |  ||. |.||. .
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

EVVKFGKYEITLTEckEEAIA-GTIWNALTVTNTedASSEPlyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK-ETPICVHCSAGVGRTATFVGID
| ..||..|.||.|  |.|.  . .  .|.|..     |    ..  .   |||.  |. | ...|| . |.... . ..|..|||||||||| | . ||
eelefgefevtlee..ekavdddflirtLkveaq..kesrk..vyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

YATIRIME---NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|.   . .   ...... |.|.|.|  |  .||.. |. ..|  ..|..
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 199-438 1.8e-51 170.2 In-house 52-290 (298) alignment 
Range on Protein: 199-438
Range on HMM: 52-290/298.0
AYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
 ...| . |||||.  .. .||||..    .. ||| ||..    |.....|.||.||.||..|||.|. .|.|. . || .| | .  |.  |.|..  
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhay.kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk

EvvKFGKYEITLTecKEEAIAGTIWNALTVTNTEDASSEplYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKET--PICVHCSAGVGRTATFVGID
|  ..|. ...|   ..|  |  |   |.|.... ....   . ....  |||. .|| |. ...| ..|.. . .    |. |.|||||||. ||. ||
e..tygeitvsll..skeefadlivrklkvskkkeeker..evrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
    |. ..  ......|. .|. | .|||.. |. |.| . .|..
svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 199-437 3e-49 162.4 In-house 16-263 (270) alignment 
Range on Protein: 199-437
Range on HMM: 16-263/270.0
AYDANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
..  .. ||||||.    .|||.|..        || | ..|   ... .||...|||| ||..|| ||..||   ..|.  | | | .||. |.|.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

EVVKFGKYEITLTECKEEAIAGTIWNALTVTntEDASSEPLYmnHVQVPWWPDQLAPEDAR------PMIELYKWVKKVNPKE---TPICVHCSAGVGRT
| ||. . .|. . ..||   | |   |...  |..... |   | .   |||. .|...        .... . |.... .    .|. ||||||||||
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

ATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEY
 |.. .|.|.  . |. ....| |..|.|  | . ||   |. ||| ...||
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 199-439 1.4e-47 157.0 In-house 39-277 (515) alignment 
Range on Protein: 199-439
Range on HMM: 39-277/515.0
AYDANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
  . |   ||| ..  .. .|| |     | . ||. || ..    |  .||..|||.. ...|||....||... . |.  | ||   ||. |.|.| |
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

EVVKFGKYEITLTEckEEAIAGTIWNALTVTNTEDASSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK-ETPICVHCSAGVGRTATFVGIDY
. ||||.... |     || .|.|   |||.  .|.      .   .   |||. .|.... .. | | ||  . . . |. .|||||||||  .. || 
dsvkfGsikvelvs..leactggikrkltvlkgddsrt....vtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisids

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
   .. .   ......|. .|. | . || . |. |.| ...|.. 
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPRK_pd Subfamily PTPRK 199-448 9.1e-43 141.3 In-house 39-288 (314) alignment 
Range on Protein: 199-448
Range on HMM: 39-288/314.0
AYDANPDLNRYADVRCIEETRVVLKNHDRD----YIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlG
  | | . ||. |.   . .||.|.  | |    || |...    |  . .| |||||.||. ||| ..|.|. | ..||  | | |  ||  |.||. .
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalids.ykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.t

EVvkFGKYEITLTECkeEAIAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KETPICVHCSAGVGRTATFVGIDY
||  .|. ...| |.  |. |  .   ..|.... . .|   ....|   |||   |  |. ...| . ||| .. .. .| |||||| ||| ||. || 
ev..ygdikvelvet..ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME-YFIGEGVVERTG
    | ..  ...  .|...|. .   |. . |. |.| |..|  . ||  .  . 
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvse
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 199-440 3.5e-39 129.8 In-house 44-290 (325) alignment 
Range on Protein: 199-440
Range on HMM: 44-290/325.0
AYDANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKiAYVLMLCTLFEGGVEKCALYYPEKLG
.  .| . ||. .|  ....||||.      . ||| ||..|   |.. .....| ||..|. |.| .... . . |...   ...| ..|| |.|...|
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemg

EVVKFGKYEITLTECkeEAIAGTIWNALTVTNTEDAssEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-------KETPICVHCSAGVGRTAT
. ..||  |. |     | |.  .   | | ....   | . ..  |.  |.|   ..    .| . . ||.|.          ||| |||||||||| .
ksktfGglevklrti..eeisdyvhrvldvkqvkkG..etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
|. .  |  ...|. ...... |. .|. | . |..  |. ..|  |.|... 
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_egg_pd Subfamily egg 199-447 1.4e-28 94.5 In-house 36-277 (307) alignment 
Range on Protein: 199-447
Range on HMM: 36-277/307.0
AYDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRmpGK-DQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGgvEKCALYYPEKL
| | | .  |   |.| . .|| |.     .  |.|||  ..  ||    ..| .| || .|  ||| |..||.. |..|| .  |   |.|  |.|   
asdnnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

GEVVKF--GKYEITLTECKEEAIAGTIWNALTVTNTEdasSEPLYMNHVQVPWwpdqlapEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVGI
 . ...  | ..|.  . ...|        | .  ..    | ....| |  .       . .  .   .. ..|.    .|. |..  || ..||.| |
sdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdv.......nnssdvysplrvlrklrnlskpvvvqdilGvskaatlvai

DYATIRIMENPNIE--MLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFigEGVVERT
. | . ..  |     .|  |  .|  |  .|.| ...||.| ... .|    |.  .
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff..rdvigsa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 200-440 7.5e-49 161.5 In-house 43-282 (318) alignment 
Range on Protein: 200-440
Range on HMM: 43-282/318.0
YDANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgE
 ..|   ||||..   ..||| |..    .. ||| |...    . . .|| .|.|||||..||| |... . | ..||  . | | .|.. |.|.|  .
epvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy.rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..g

VVKFGKYEITLTECKEeaIAGTIWNALTVTNTEDASSepLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN--PKETPICVHCSAGVGRTATFVGIDY
  ..||  ..|.| .|  ..  .   ..||.||  .|    .   ..  |||.  ||..  ...| . |.|..  ....|| |||||||||| .|. .| 
srsygklvvelkeeve..lsdyvlrefkvtrteeees..rqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdi

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
   || ..  ......|...|  |   || . |. |.| ||.|. . 
llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 201-438 1.9e-54 179.7 In-house 45-279 (288) alignment 
Range on Protein: 201-438
Range on HMM: 45-279/288.0
DANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEV
  | . ||| ..  ..|.|| ||.    .. ||| ||..   .| . .||.|||||..|. |||...|..|.  ..||  | ||| .||  |.|.. .. 
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkp

VKFGKYEITLTECKEEaiAGTIWNALTVTntedASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-TPICVHCSAGVGRTATFVGIDYAT
...|. ..||.| ||.    .. . | .      . . | ... |   |||.  ||...|..|| . ||  |...  || |||||||||| ||. .| . 
knyGsvtvtlveskel..edfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali

IRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 .. |.  |.....| ..|  |.. ||   |. |.| ||..  
daveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 201-439 2e-46 153.3 In-house 42-278 (315) alignment 
Range on Protein: 201-439
Range on HMM: 42-278/315.0
DANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEV
. |   ||| ..  ....||.|    .. |.||| || ..   .|  .||..||||. ...|||.|..|||.. . |.  . ||   ||. |.|.. .. 
tinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

VKFGKYEITLTECkeEAIAGTIWNALTVTNTEDASSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKV-NPKETPICVHCSAGVGRTATFVGIDYAT
|.||.....| .   || ....   |.. ..|.       .   |   |||. .....  ...| | ||   ..|| .. ||||||||||  .. ||   
vefGsikvellsl..eadtdgvarklvtrkseesrt....vtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

IRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
 .| ..  ......|...|| | . ||.. .. |.| ...|.. 
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 201-440 5.1e-30 99.4 In-house 31-259 (267) alignment 
Range on Protein: 201-440
Range on HMM: 31-259/267.0
DANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEkcaLYYPEKLGEVVKFG
  | . ||. |.   ..|||.|......|| ||..    | . ..| ||.||  | .||. .| ..|.. . .| . |.. .    |..| |.|.  |. 
eknqernrlddnlpyddtrvilrtkeeeyinasyvegy.ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir...lfwPPkmgqakkyq

KYEITLTECKEEAIAGTIWNALTVTNtEDASSEPLYMNHVqvpWWPDQLAPEDARPMIELYKWvKKVNPKETPICVHCSAGVGRTATFVGIDYATIRIME
   .  .  |||     |   | . | | |    ||  .    |  .       .|.. .    ....  . |. |.||.||||. ||. ||    |. .
dltvehslekeendyqiitlelkfkn.esahnvtlyyykk...wnintnnkpylkplfgilak.nqlengnrPlvvacsdGvGrsGtflvidsqlerakt

NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYfiG
.   .. | .|..|  |   |..  ...... .| ||   
egvsdifdflrkirsqriglvdtkeryiyihellaey..a
subfamily_ptpA1_pd Subfamily ptpA1 201-390 3.5e-23 77.0 In-house 45-248 (418) alignment 
Range on Protein: 201-390
Range on HMM: 45-248/418.0
DANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRmpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEV
  |   |||...  .. ||| ||.       ||| | ..   |     .| ||||||.|..|||.|.....   ..||    |    ||  |.||..|  
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid..gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

---------VKFGKYEITLTECKEEAIAGTIWNALTVTNTEdassEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKK----V---NPKETPICVHCSA
           || | . | |  ..     |   . .|       |   . . |   |||.  |. ..|. .| . . .    .   . .. || |||||
qfsiygngnevfgtysvelveviqdpereiitrnirltfeg....etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsa

GVGRTATFVG
||||| ||. 
gvgrtgtfct
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 202-438 1.2e-47 157.2 In-house 8-242 (250) alignment 
Range on Protein: 202-438
Range on HMM: 8-242/250.0
ANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEkCALYYPEKLgeVV
.| . |||||.  ....||||....     ||| ||..    .  ...|.|||||..|. ||| |...||.. ..|| .| | . . .  |.| .     
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..ae

KFGKyeITLTECKEEAIAGTIWNALTVTNTEDASSEplYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK--ETPICVHCSAGVGRTATFVGIDYAT
|.|.  .|..  ..|  |  .   | ..... |..    . ...   |||.  || |. ..|| | |.. ...  ..|. |.|||||||. .|. ||   
kyGd..vtvsllskeefadytkrklklskakkader..ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

IRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 |. ..  ... .... .|. | .||.|. |. |.| ..... 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 202-440 8.5e-41 134.9 In-house 48-281 (315) alignment 
Range on Protein: 202-440
Range on HMM: 48-281/315.0
ANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgeVV
 | . ||| ..   ...|| |    .. . ||. |...    | .  ||..|||..... ||| ....|.|. ..||  | ||  .|.  |.|.|    |
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynk.krryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv

KFGKyeITLTECKEEAIAGTIWNALTVTNTEDASsEplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-TPICVHCSAGVGRTATFVGIDYATI
 .||  ||.|  .||        .|.|.  ..   |   .  ...  |||   |. . |...|.. ||. . .. ..| |||||||||| ||. .|    
iyGk..itvtrkseevnteytvrtlsvvfgdnir.e...vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld

RIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
..  .  |.. .... .|..| ..||.  |. |.| .|.| |. 
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 202-438 6.7e-31 102.1 In-house 37-277 (287) alignment 
Range on Protein: 202-438
Range on HMM: 37-277/287.0
ANPDLNRYADVRCIEETRVVLK---NHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVK
|.   ||||||  |..|||.|    ..  ||| | ..    .|. ..|..|||.. |. ||| ...... | |...    | .  ||  |.||.    ..
aavkknryadvlPiddtrvllsaegelGsdyinanyvasy.tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

FGKYEITLTECKEEAIAgTIWNALTVTNTEdaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWV------KKVNPKETPICVHCSAGVGRTATFVGID
 | | ..| . .          || . . |  . |   .. ...  |||. ..  |  .| .   |      ..   .  |. ||...|.||. ... . 
vGGysvvlldydikePe.ygvralrlidle..trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
    |  .  ....  .|  .|  |   ||. .|. .||  |. |.
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
Y_phosphatase Protein-tyrosine phosphatase 203-436 2.9e-71 235.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 203-436
Range on HMM: 1-235/235.0
NPDLNRYADVRCIEETRVVL--KNHDRDYIHASWMRMPGkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFG
| . ||| |. ....||| |  .... |||.|.....   .....| |||||..|..|||.|..|||. .. ||..| | | |||| |.||. .| ...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

KYEITLTeCKEE-AIAGTIWNALTVTNTEDASsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKETPICVHCSAGVGRTATFVGIDYATIRI
.....|.  ||. . .... . |....... | |.  ......  |||. .||.......| . |.| . .|..|..||||||||||.||| .|..  ..
dikvelk.ekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 .. ....|.||.|.|. |...|||  |. ||| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 203-436 2.9e-71 235.0 In-house 1-235 (235) alignment 
Range on Protein: 203-436
Range on HMM: 1-235/235.0
NPDLNRYADVRCIEETRVVL--KNHDRDYIHASWMRMPGkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFG
| . ||| |. ....||| |  .... |||.|.....   .....| |||||..|..|||.|..|||. .. ||..| | | |||| |.||. .| ...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

KYEITLTeCKEE-AIAGTIWNALTVTNTEDASsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKETPICVHCSAGVGRTATFVGIDYATIRI
.....|.  ||. . .... . |....... | |.  ......  |||. .||.......| . |.| . .|..|..||||||||||.||| .|..  ..
dikvelk.ekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 .. ....|.||.|.|. |...|||  |. ||| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 203-436 1.4e-45 150.4 In-house 50-279 (301) alignment 
Range on Protein: 203-436
Range on HMM: 50-279/301.0
NPDLNRYADVRCIEETRV-VLKNHDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGK
. | .||  | |  .| | |...  |  ||| |.  .|. .  .|.|||||..|  ||| |. | ..  . ||.   |  .|||. |.| | .| .. |.
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

YEITLTECKEEAIAGTIWNALTVTNTEDAsSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKvnpKETPICVHCSAGVGRTATFVGIDYATIRIMEN
..|.... .      ..  .| |... .   ..  . | |   |.|.  |.    . .| . |||    | || ||||||.||. .|.| .| . ..  .
fkikiknkelilnkkiskrtlevedstgk.fatrtvthyqysewtdrgvPkshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteylarevead

PNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
|.||. . ....|  |...|| . |. .. .  . 
ptieltealkhlrehrwngvqtnsqlywmtlGtvy
subfamily_PTPN6_pd Subfamily PTPN6 203-438 1.3e-44 147.4 In-house 54-297 (306) alignment 
Range on Protein: 203-438
Range on HMM: 54-297/306.0
NPDLNRYADVRCIEETRVVLKNH---DRDYIHASWMR--MPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVV
|   |||  .   ..|||.||..   . ||| |. ..  ..|.|  .||.||| |..|.||||.|..||.   ..|. .  | | |||| |.|..  .  
nkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

kFGKYEItlTECKEEAIAGTIWNALTVTNTEDaSSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK-----ETPICVHCSAGVGRTATFVGID
 .||...  |...|.. |  |   |.|..... ..|  .. . .   |||.  |.|   .... . |.. . .     . ||.||||||.||| ||. ||
.yGkisv..tnvseksladYilRelsvskkkk.kkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviD

YATIRIMEN---PNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
  .  |...    .|.. ..|. .|. | . || . |. |.| .. .| 
illkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
0041856 (Phosphotyrosine protein) phosphatases II 203-440 2.3e-42 140.0 In-house 1-173 (182) alignment 
Range on Protein: 203-440
Range on HMM: 1-173/182.0
NPDLNRYADVRCIEETRvvlknhDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCtlfeggvekCALYYPEKLgevvkfgky
| |.||| |. ... .|      | |||.|...... ...  .| |||||..|. ||..|.....| ....|.         . ||.||.|         
nldknrysdilpydhsr......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.........

eitlteckeeaiagtiwnaltvtntedassePLYMNHVQVPWWPDQLAPEdarpMIELYKWVKKVNPKETPICVHCSAGVGRTATFVGIDyatirIMENP
                               . .  ...   |||  .|.    . ||......|. .. |. ||||||||||.|.|...     .|.  
...............................erlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaay.....lmkkl

NIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
.. . ..|...| .|...|..  |. ||. .|.|.. .
gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 204-436 6.8e-34 112.1 In-house 8-238 (239) alignment 
Range on Protein: 204-436
Range on HMM: 8-238/239.0
PDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgeVVKF
   ||||..   . .||||..       ||| ||..|       .||.||| .  .  |||.|..||. . ..||  | ||  .||  |.|.      |.
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsky

GKYEITLTecKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVpwWPDQLAPEDARPMIELYKWV-KKVNPKETPICVHCSAGVGRTATFVGIDYATIRI
 .  .||   | | .|  |  .. ...  ..    .|  |. |  |||.  |. |  .. | . . |   |   |  .||||||||| .|. ||    . 
cnlrvtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 ..  ..... |. .|  | . ||.  |..|... ..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 204-436 8.6e-34 111.7 In-house 9-239 (239) alignment 
Range on Protein: 204-436
Range on HMM: 9-239/239.0
PDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgeVVKF
   ||||..   . .||||..       ||| ||..|       .||.||| .  .  |||.|..||. . ..||  | ||  .||  |.|.      |.
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsky

GKYEITLTecKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVpwWPDQLAPEDARPMIELYKWV-KKVNPKETPICVHCSAGVGRTATFVGIDYATIRI
 .  .||   | | .|  |  .. ...  ..    .|  |. |  |||.  |. |  .. | . . |   |   |  .||||||||| .|. ||    . 
cnlrvtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 ..  ..... |. .|  | . ||.  |..|... ..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 205-438 9.1e-49 161.0 In-house 30-268 (274) alignment 
Range on Protein: 205-438
Range on HMM: 30-268/274.0
DLNRYADVRCIEETRVVL-----KNHDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGE--VV
  ||| ..   |..||.|     ...| .|| | ... ..... .|. ||||||.|..|||.|||||..  ..||  | |   .||| |.|.. .     
tknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeise

KFGKYEITLTECKEEaiAGTIWNALTVTNTEDASSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKV----NPKETPICVHCSAGVGRTATFVGIDY
..|. ||. .. .|.   .   . |.. ..|.  |    . |   . |||. .|.||.....| . |..     | | .|. ||||||.|||  |..|. 
rygdveikvekiver..ndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|  .. |.  ...| || ..|  |   ||.. |. ... .|..| 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 205-447 1.6e-44 146.9 In-house 50-296 (305) alignment 
Range on Protein: 205-447
Range on HMM: 50-296/305.0
DLNRYADVRCIEETRVVLKN-HDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYE
. ||| || |... || |..    .|||| ..  | . .  .| || || .| .|||.| .|.|. ...||| | | | .||. |.. | ..|..| . .
gknrykdvgcldnnrvklegpwpheyihanyvstptnpk.rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

ITLTECKEEAIAGTI--WNAL----TVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELykwVKKVNPKETPICVHCSAGVGRTATFVGIDYATIR
  ..   | . .  .    .     ||   | . .. . ..|     |||.  |     ..||   ..|  |   || ||||||.||| . | ..|   .
qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel...lekarpskgpivvhcsagigrtgsvvmleyildq

IMENPNIEMLD-IVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERT
...   ||  | |.. .|  | ...|.  |.||.. |...||  ..... .
llagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee
subfamily_CG42327_pd Subfamily CG42327 205-360 7.8e-19 62.5 In-house 30-186 (319) alignment 
Range on Protein: 205-360
Range on HMM: 30-186/319.0
DLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG--EVVK
| .|...|  . ||||||..        |..||..| . . .. ||..| .| .. |||| .... .   .. |. |.| |...|| |.| | .  .   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FGKYEITLTECKeeAIAGTIWNALTVTNTEDASSEPLymNHVQVpWWPDQLAPEDARPMIEL
.|.. .|| . .  .    .  .| . . ..  | .|   |     |..   | . ...| .
yGdilvtlkgre..vkdryaistlllkrvdkeesrel..thywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 206-459 5.2e-34 112.7 In-house 21-272 (290) alignment 
Range on Protein: 206-459
Range on HMM: 21-272/290.0
LNRYADVRCIEETRVVLKNHDR----DYIHASWMRMPgkDQSTYITTQGPLPET-------LSDFWHMIYQEKIAYVLMLCTLFEGGVE----KCALYYP
... ..|  .|.||||||.. .    |||||. . .|  .    | || |. ..       . .|| |. |||.  | |||   |   .     || |.|
mdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcp..nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

EKLGEVVKFGKYEITLteCKEEAIAGTIWNALTVTNTEdasSEPLYMNHVQVPWWPDQLAPEDARPMIELykwVKKVNPKETPICVHCSAGVGRTATFVG
|. || .||.  ..    .. |.  . .   |.|.  .    |.. ..| ..  | .  ..|| . ...|   ..||. ..||. |||  |. | |..  
esvgeelkfkgltvkC..kskekeddvetRelvvkfdd...eeeftvtHsllkgWnklnvqedtktllsl...iqkvkasktpvivHcvdGiSrsAalaa

IDYATIRIM-ENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMeyfigegvvertG----RVDTFMTQYKK
|. .   |.  . .... |.. ..| .| .|..|.... |   ...                   |.|......
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv............llaievldqfaeeete
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 206-435 7.3e-34 112.0 In-house 6-236 (237) alignment 
Range on Protein: 206-435
Range on HMM: 6-236/237.0
LNRYADVRCIEETRVVLKNH--DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVKFGKYE
 |||..... . .|||||    . ||| |....       .||..||||  .  ||| |..||| . ..||  | ||  .||  |.|.   .   .|.. 
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvlt

ITLteCKEEAIAGTIWNALTVTNTEDASsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP---KETPICVHCSAGVGRTATFVGIDYATIRIME
..|  .|.|...     .|....      |  ..   |   |||.  |. .  .. . | . . .|   . .|  .|||||||||. |. ||    .  |
vsl..kkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLM
.  ... . |  .   |   .|.. |..|.. ...
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 206-355 1e-22 75.3 In-house 36-184 (297) alignment 
Range on Protein: 206-355
Range on HMM: 36-184/297.0
LNRYADVRCIEETRVVLKN--HDRDYIHASWMRMPGKDQS-TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKY
 ||| |.   ..||| |..   .|||| | .. .| ...   || .|||| .|. |||...... .  . |.. | |.| .||| |.|.  .|  | |..
knryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdv

EITLTECKEEAIAGTIWNALTVTNTedasSEPLYMNHVQVPWWPDQLAPEDAR
 .       .     |   |..       ||  ...|||   |||   | |  
vveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 207-292 2e-17 58.0 In-house 51-153 (350) alignment 
Range on Protein: 207-292
Range on HMM: 51-153/350.0
NRYADVRCIEETRVVLK---------NH---DRDYIHASWMRMP--GKD--QST-YITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
||| ..   | .|| ||         .|     ||| |......  ...   .  || ||.|||.|. ||...|.. |.  .|.| ...| ..|||  |.
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

PEK
.| 
qeg
0044763 (Phosphotyrosine protein) phosphatases II 216-437 9.5e-31 102.2 In-house 3-170 (178) alignment 
Range on Protein: 216-437
Range on HMM: 3-170/178.0
EETRVVLKNHDR----DYIHASWMRmPGkdqsTYITTQGPlpetlSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGevvkfgkyeitltecke
..|||.| |  .    |||.||..  ||     |.....|     .|.. ......| ....|.. .|.| .||  |.||. |                 
drtrvllsnleglersdyinaseil.pg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

eaiagtiwnaltvtntedasseplyMNHVQVpWWPDQLAPEDARPMIELYKWVKKVN-PKETPICVHCSAGVGRTATFVGIDYATIRimenpNIEMLDIV
                         ......  .||  .|.  . . |........  .|. |. |||||||||..|.| ...   .     .. . ...
.........................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

REMRAMRFqAVQSHMQFLFLYVVLMEY
...|..|. .|..  |  .|| . ...
elvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 220-437 1.2e-37 124.7 In-house 5-172 (176) alignment 
Range on Protein: 220-437
Range on HMM: 5-172/176.0
VVLKNHDRDYIHASWMRMPgkdqsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVkfgkyeitlteckeeaiagtiw
.   . | |||.|... ..      .|.||||||.|| ||..|.....| .|..|....| |  ||. |.||  .. .                      
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

naltvtntedasseplymnHVQVPWWPDQLAPEDaRPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVGIDyatirIMEN-PNIEMLDIVREMRAMRF
                   ....  |||  .|.. . ..||.......  .  |. ||||||.|||.|.| ..     ..|   .. ........|..|.
...................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRp

-QAVQSHMQFLFLYVVLMEY
 .|||.  |  ||| .....
lgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 225-431 9.7e-38 124.9 In-house 3-154 (172) alignment 
Range on Protein: 225-431
Range on HMM: 3-154/172.0
HDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtiwnaltv
...|||.||.. .. . .. .| |||||..||.|||.|.....| ....|..|                                               
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel...............................................

tnTEDASSEPLYMNHVQVPWWPDQLAPeDARPMIELYKWVKK--VNPKETPICVHCSAGVGRTATFVGIDYATirimenPNIEMLDIVREMRAMRFQAVQ
  . |.. .  .  ...   |||. .| ... ..|.......  .. .. |..||||||||||.|.| ...         .. ....|...|..|..|||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

SHMQFLFLY
.  |  |||
npsqyrfly
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 225-346 3.2e-07 24.7 In-house 11-122 (130) alignment 
Range on Protein: 225-346
Range on HMM: 11-122/130.0
HDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLctlfeGGVEKCALYYPEKlgEVVKFGKYEITLTECKEEAIAGTIWNALTV
.. .||.||.. . |.  . |. || || .|  |||.|. .  .  ...|     | ||.   |.|.   | ... . .|..|  . .       . | .
qgntyinasfvGllgrt.aeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpds..ePlewyeediivtltdrdefknikasnlei

TNTEDASSEPLYMnhVQVPWWP
 .    | . | |  .|.  ||
esdlneshqaltm..fqisnwp
0036282 (Phosphotyrosine protein) phosphatases II 227-431 3.3e-37 123.2 In-house 2-163 (174) alignment 
Range on Protein: 227-431
Range on HMM: 2-163/174.0
RDYIHASWMRMPGKDQsTYITTQGPLPetlsdFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEklgevvkfgkyeitlteckeeaiagtiwnaltvtn
 |||.||.. .       .| .||||.     ||.|.....| .|.||....| | .||  |.||                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

teDASSEPLYMNHVQVPWWPDQLAPEDARpMIELYKWVKKVNPK--ETPICVHCSAGVGRTATFVGIDYATIRIMeNPNIEMLDIVREMRAMRFQAVQSH
  . ...  .  ...   |||  .|...  ..|..|.|...  .  . |. ||||||||||.|.|....   ... .. .. ||.|||.| .| ..||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

MQFLFLY
 |. |||
sQyrfly
0051429 (Phosphotyrosine protein) phosphatases II 227-446 1.6e-36 121.7 In-house 4-246 (272) alignment 
Range on Protein: 227-446
Range on HMM: 4-246/272.0
RDYIHASWMRMPgKD---QSTYITTQGPLPETLSDFWHMiYQEKIAYVLMLCTLFEGGVEKCALYYP----------EKLGEVVKFGKYEITLTECKEEA
 .||.|... ..        ... ..|||| |  |||.. ....| ....|....| | .|| .| |          .   . . .|.. .||....   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

IagTIWNALTVTNTEDASSEpLYMNHVQVPWWPDQLAPEDArpMIELYKWVKKvnpkETPICVHCSAGVGRTATFVGIDYATIRIMENPNIE--------
   .|.  |..|.. .|.   . . | .   |||  .|..|  ..|| ... .    . |. ||||||..||.|.| ...   .. ..  ..        
d..yilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

MLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGE-------------GVVER
....|.|.||.| .|||. .|.|||| .|.|.. .               . |.
leeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaidee
0051082 (Phosphotyrosine protein) phosphatases II 227-435 2.2e-27 90.9 In-house 3-150 (151) alignment 
Range on Protein: 227-435
Range on HMM: 3-150/151.0
RDYIHASWMRmPGkdqstYITTQGPLPetlsDFWHMIYQEKIAYVLMLCTLFEGGveKCALYYPEKLgevvkfgkyeitlteckeeaiagtiwnaltvtn
 |||..|..  .|     .. ..|||.    ||. ......| ....|....| |  .|. |.||                                   
sdyinfsyvt.gg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tedassepLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKvnPKETPICVHCSAGVGRTATFVGIDYATIRimenpnIEMLDIVREMRAMRFQAVQSHMQ
        .   |.... |||.  |.    ..|. ... .  .|. |. ||||||.|||.|.|...    .      . . ....|.|..|. .||...|
........ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

FLFLYVVLM
|||.. .|.
flfqlfall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 227-292 1.1e-11 38.7 In-house 90-156 (349) alignment 
Range on Protein: 227-292
Range on HMM: 90-156/349.0
RDYIHASWMRMPGKD-QSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEK
 ||| | .....  . .  ||.|| ||| |. ||...|  ...  || |   .| ..|||  |. | 
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_eak_pd Subfamily eak 227-310 4.5e-11 36.7 In-house 78-160 (332) alignment 
Range on Protein: 227-310
Range on HMM: 78-160/332.0
RDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECK
  || || . ..   .  || |  .  . .  || |....|   ...|    | ..||   |.|.|  |..|||.....  |  
lGyinaslaefsevGr.kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 228-353 6.1e-07 23.3 In-house 123-239 (244) alignment 
Range on Protein: 228-353
Range on HMM: 123-239/244.0
DYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLctlfeGGVEKCALYYPEKlgEVVKFGKYEITLTECKEEAIAGTIWNALTVTNT
 || ||..   |.  . || || || .|  |||.|. . ..  ...|     | ||.   |.|.   | ... . .||.|    . .       | .   
tyinasfvgclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpds..eplewyeeditvtltdrdefknikasnleiesd

EDASSEPLYMnhVQVPWWP-DQLAPED
 . | . | |   |.  || |  .|.|
mneshqaltm..fqisnwpsdgttpnd
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 237-435 6e-33 108.6 In-house 83-285 (302) alignment 
Range on Protein: 237-435
Range on HMM: 83-285/302.0
MPGKDQSTYITTQ--GPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTIWNAL-----TVTNTED
| | ..   .. .   |  .||  .| .| | ..| |  ||.. |.. .||| || .|.|...|||.| ..  . |..    |  ...      ..|.. 
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

ASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVnpkETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLF
 .  .  .. ..   |||  ||..| . ... |. .      . . |||||||||| |.| | |     ...   ..|.||  .|. |. |||.. | ..
kkkvkktvdilafsawpdhGapkeaytaldilkfcesy...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

LYVVLM
| ... 
lllcvt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 240-432 1.2e-15 52.2 In-house 2-198 (199) alignment 
Range on Protein: 240-432
Range on HMM: 2-198/199.0
KDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAiAGTIwNALTVTNTEDASSEPLYMNH
| |  ||.|| || ||..||| |...    ...|.           ..|.|     . |.|   .|      ..   ||  || .||   |      . |
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dyti.taliltnnttappstreish

VQVPWWPDQLAPEDARPM--IELYKWV-KKV-NPKETPICVHCSAGVGRTATFVGIDYAtIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYV
 |   | .. .|. |  .  .   . | ||  . |..|. |||| | | |  || .|   .|  |. .   ...... . .|  |   . |  .. |.| 
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldig.vrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 240-432 1.6e-15 51.8 In-house 1-197 (198) alignment 
Range on Protein: 240-432
Range on HMM: 1-197/198.0
KDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAiAGTIwNALTVTNTEDASSEPLYMNH
| |  ||.|| || |||.||| |...    ...|.           ..|.|     . |.|   .|      ..   ||  || .||   |      . |
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dyti.taliltnnttappstreish

VQVPWWPDQLAPEDARPM--IELYKWV-KKV-NPKETPICVHCSAGVGRTATFVGIDYAtIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYV
 |   | .. .|. |  .  .   . | ||  . |..|. |||| | | |  || .|   .|  |. .   ...... . .|  |   . |  .. |.| 
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldig.vrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 241-445 7.7e-29 95.5 In-house 33-228 (255) alignment 
Range on Protein: 241-445
Range on HMM: 33-228/255.0
DQSTYITtqgplpeTLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTEckeeAIAGTIWNALTVTNTEDASSEPLYMNHV
 ...|.        |.  |...| | |   | ||| . | |||||  |.| .. |  |. . ..| |.    ..|  .  .|..| |     .   ..| 
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhy

QVPWWPDQLAPEDARPMIELYKWVKKVnpkeTPICVHCSAGVGRTATFVGIDYA------TIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVL
.   |... |||.|| . ...| |..      .. ||||.|.||.|.|| ....      ...  |  ... | ...|.| .| .|..  .|. |  ...
sykGWieknaPelareilnilkvvrds....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv

MEYFIGEGVVE
....  .| .|
ldlvfpkgele
subfamily_hpo-7_pd Subfamily hpo-7 242-440 4.3e-25 83.1 In-house 37-229 (263) alignment 
Range on Protein: 242-440
Range on HMM: 37-229/263.0
QSTYITtqgpLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTIwnalTVTNTEDASSEPLYMNHVQ
...|.     | .|.  |...| | |   | |||   | |||||  |.| .. |  |. . ... |. ... .  |.     ...| .   .   ..| .
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktl....ellstlgeKkkthtvkhys

VPWWPDQLAPEDARPMIELYKWVKKVnpkeTPICVHCSAGVGRTATFVGIDYA------TIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLM
   |... .||.|| .... | ...      .. ||||.|.||.| |. .. .      ...  .  ... | ...|.| .| .|..  ||. |  ....
ykgWiekndpelareilnilkvarns....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

EYFIG
.... 
dfvln
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 242-304 2.7e-06 21.0 In-house 235-293 (440) alignment 
Range on Protein: 242-304
Range on HMM: 235-293/440.0
QSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEggvEKCALYYPEKLgEVVKFGKYEI
. ..|.|| ||  |. ||| .... .|. ..||  | .     |..|.| .    | || . .
knafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt.rsvtfgpftv
0049260 (Phosphotyrosine protein) phosphatases II 244-431 8.1e-34 111.9 In-house 10-143 (152) alignment 
Range on Protein: 244-431
Range on HMM: 10-143/152.0
TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYpeklgevvkfgkyeitlteckeeaiagtiwnaltvtntedasseplymnHVQVP
 .| ||||.|.||.|||.|... .| ...||..|.| | .||. |.                                                 ...  
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qylhl

WWPDQLAPEDARPMIELYKWVKK-VNPKETPICVHCSAGVGRTATFVGIDYATirimenPNIEMLDIVREMRAMRFQAVQSHMQFLFLY
.|||  .|...  ...|.....|    |. |. ||||||||||.|.| ...         .......|. .|..| .||... |  |||
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 256-438 1.5e-12 40.8 In-house 131-309 (346) alignment 
Range on Protein: 256-438
Range on HMM: 131-309/346.0
LSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVKFGKYEITlteCKEEAIAGTIWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPeDAR
. |||.|||||.|  | ..           .|.  |. |     ||  |     .   ..|   .       |  |   .   | . ||   |  |  . 
vedfwymiyqeqihlvylmvpddklkntttslfnden.ggyqytgkmfin...nrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqpp.ktl

PMIEL-YKWVKKVNPKETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|.| . ...  . . ... .||    | ||. .|.|  ||  .. .  . ....|.....  |  .|.|  |.  .| ....| 
piikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
0048179 (Phosphotyrosine protein) phosphatases II 318-432 4.1e-21 70.7 In-house 30-139 (144) alignment 
Range on Protein: 318-432
Range on HMM: 30-139/144.0
IWNALTVTNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVGIDyatirIMENPNIEMLDIVREMRAMR
|.  ...|.. .  ..  .  ...   |||  .|...  ..|........ ... |. ||||||||||.|.| ..     .|   .. . ......|..|
ittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrr

FQAVQSHMQFLFLYV
..||..  |. ||. 
pgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 322-437 4.9e-22 73.6 In-house 34-142 (145) alignment 
Range on Protein: 322-437
Range on HMM: 34-142/145.0
LTVtnTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVGIDyatirIMENPNIEMLDIVREMRAMRFQAV
|..  | . . .  .  ...   |||  .|.... ..|........ ... |. ||||||||||.|.|...     .|   .. . ......|..|..||
lnl..tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay.....lmlllgvsleealelvrsqrpgav

QSHMQFLFLYVVLMEY
..  |. ||| ...|.
pnpgqlrflyefelel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 322-438 3.3e-13 44.1 In-house 202-344 (350) alignment 
Range on Protein: 322-438
Range on HMM: 202-344/350.0
LTVTNTEDASSEPLYMNHVQVPWWPDQ---LAPEDARPMIE--------LYKWVKKVNPKETPICVHCSAGVGRTATFVGIDYATI--RIMENPN-----
 ..|. . |.|.|. . ..||  |.|    | ||.  ...|        |.      | . .|| |||||||||| |.| .|.      |.|| .     
nsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrk

I----E----MLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.    .    .  || |.|  | . ||.  ||.|.|  |. ||
ldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
PTPc_motif_SM00404 324-428 5.2e-08 27.9 In-house 34-131 (140) alignment 
Range on Protein: 324-428
Range on HMM: 34-131/140.0
VTNTEDASSEPLYMNHVQVPwWPDQLAPEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVgIDYatirIMENPNIEMLDIVREMRAMRfQAVQS
||.. ....|   ....|.|   |.   . .. . .... ..... |.. . ||| ||| |.||.. | |    .|.  .... . .. ..  | .... 
vteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli.iaY....lmryrqlslaeayefvkerR.piisp

HMQFL
 ..|.
nlnfv
PTPc_DSPc_SM00012 337-436 6.7e-30 98.8 In-house 2-105 (105) alignment 
Range on Protein: 337-436
Range on HMM: 2-105/105.0
MNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE---TPICVHCSAGVGRTATFVGIDYATIRIMEN-PNIEMLDIVREMRAMRFQAVQSHMQFLFLYV
..|.... |||. .||.. ...|| . |||.. |.   .|..||||||||||.||| .|..  .....  ......||.|.| .| ..||. .|.|||| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLME
.|.|
alle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 337-443 2.2e-11 37.7 In-house 93-200 (440) alignment 
Range on Protein: 337-443
Range on HMM: 93-200/440.0
MNHVQvpWWPDQLAPEDARPMIELYKWVKKVNPK--ETPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVL
  | |   |||.  |. | |.... . |.. . |  . |. ||||||.|||.  . .|        . .|... ..  ||  | | ||.  |. |.. ..
qyhyq..gwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

MEYFI-GEGV
.| .. |. .
legllcgdtl
DSPc Dual specificity phosphatase, catalytic domain 339-428 3.9e-07 25.0 Pfam-A 42-124 (133) alignment 
Range on Protein: 339-428
Range on HMM: 42-124/133.0
HVQVPwWPDQLAPEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVgIDYatirIMENPNIEMLDIVREMRAMRfQAVQSHMQFL
....|   |.   . .. . |... ..|.  |.  . ||| ||. |.||.. | |    .|.  |... . .. ..  | ...   ..||
ylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknlslneAyefvkerr.skispnagfl
DSPc Dual specificity phosphatase, catalytic domain 339-428 3.9e-07 25.0 In-house 42-124 (133) alignment 
Range on Protein: 339-428
Range on HMM: 42-124/133.0
HVQVPwWPDQLAPEDARPMIELYKWVKKVNPKETPICVHCSAGVGRTATFVgIDYatirIMENPNIEMLDIVREMRAMRfQAVQSHMQFL
....|   |.   . .. . |... ..|.  |.  . ||| ||. |.||.. | |    .|.  |... . .. ..  | ...   ..||
ylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknlslneAyefvkerr.skispnagfl
0038934 (Phosphotyrosine protein) phosphatases II 344-427 5.2e-08 28.3 In-house 86-166 (194) alignment 
Range on Protein: 344-427
Range on HMM: 86-166/194.0
WWPDQLAPEDARPMIELYKWVKKVNPK--ETPICVHCSAGVGRTATFVGIDYatiriMENPNIEMLDIVREMRAMRFQAVQSHMQF
 .||. .. .   . . ...|.... .  .  . ||| ||.|||.|.|.        ..  .. . . .. .| .|  |...  ..
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 366-434 4.3e-09 30.6 In-house 223-291 (297) alignment 
Range on Protein: 366-434
Range on HMM: 223-291/297.0
KVNPKETPICVHCSAGVGRTATFVGIDYA--TIRIMENPNIemLDIVREMRAMRFQAVQSHMQFLFLYVVL
   |..... |||||||||.   |  |     .|    |..    |.. .|  | . ||.  || .|| . 
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdv..aailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 368-438 9e-07 22.5 In-house 262-344 (349) alignment 
Range on Protein: 368-438
Range on HMM: 262-344/349.0
NPKETPICVHCSAGVGRTATFVGIDYATIrIMENPNIEM-------------LDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
. . ... |||||| ||| ..| .|.    |.| .. |.               || |.| .|.. ||   || ..|  |..||
tdqlstllvhcsaGcGrtGvlvtldllls.ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_CG42327_pd Subfamily CG42327 371-437 9.5e-12 39.2 In-house 247-314 (319) alignment 
Range on Protein: 371-437
Range on HMM: 247-314/319.0
ETPICVHCSAGVGRTATFVGIDYAtIRIMENP--NIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEY
  |. |||| ||||| . .  | | || .|..   ... ..|  .|  | .||..  |. |.| || ||
qGPlvvhcsdGvGrtGlviasdia.irsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 375-436 1.3e-07 25.9 In-house 2-63 (69) alignment 
Range on Protein: 375-436
Range on HMM: 2-63/69.0
CVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 ||||.| ||| ||. |     ||  .  ..... |. ||  |   |   ....|..  |.|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 376-436 3.4e-07 24.5 In-house 2-62 (69) alignment 
Range on Protein: 376-436
Range on HMM: 2-62/69.0
VHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
||||.| ||| ||. |     ||  .  ..... |. ||  |   |    ...|..  |.|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve