Gene F35C11.2 in Caenorhabditis elegans

Synonym: CELE_F35C11.2, F35C11.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf12
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP076_AA protein Get Run
CeleP076_AA_55-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 43-173 6.2e-10 33.6 In-house 10-139 (306) alignment
Range on Protein: 43-173
Range on HMM: 10-139/306.0
EGKEEEVNKnvTPEEAFKAVTVEGPELLNQMHTSaMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK-DDFYNASWVDGYSK--KSAYIFAQAP
| ...|..|  . |.  ||   |  | |.|....  ..  .  .  .|.  ||.     |||.|| |. .. . .|. ||. ... .|  . .|| .|  
eqrvselek..eeeslekagfeeefeelqqeeak.kllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgc

FNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRK
... |   ||||| . .  .|..     |. | |
let.tvsdFWrmvwqensrvivmttkevErgkek

0043336 (Phosphotyrosine protein) phosphatases II 56-355 2.7e-42 140.5 In-house 15-274 (278) alignment
Range on Protein: 56-355
Range on HMM: 15-274/278.0
EEAFKAVTVEGPELLNQMHTsamtYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPfNDHTEYVFWRMVS
  ..|... .. | |.....    .. .. ....|.|.||... ...||||| | . .|   .|..|||.||||... ..| .|.| ...|.. ||||| 
llnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgP.lpetvedFwrmvw

ERKPSMILVFGDIDEKQKRKapydisdrgfeksflhefgaksleecelkakiCRKFWPekGSKKDFPALSIQASDDHSETHMKTFNLTVT--EKKQDHQT
| . ..|..  . .|... |                                | ..||  |. . .  ...   . ... ......|.||   ... .. 
elgvttivmLtelvelgrvk................................caqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtv

VLMHFYEWADASKL--PEYMLDMRASIKLQYIrsS-KktgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYS
. .|.. | | .    .. .||.   .. ..   . .      ||..  |  || ... ...........  |..| . |... ...||.|.. |   | 
thyhylgwpdhgvpeslsllldflkavreale..dsn......gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr

TACEMLM
  .|.|.
flyeall

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 57-388 5.6e-246 808.9 In-house 1-332 (332) alignment
Range on Protein: 57-388
Range on HMM: 1-332/332.0
EAFKAVTVEGPELLNQMHTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEYVFWRMVSERK
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
eafkavtvegpellnqmhtsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserk

PSMILVFGDIDEKQKRKAPYDISDRGFEKSFLHEFGAKSLEECELKAKICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHF
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||
psmilvfgdidekqkrkapydisdrgfeksflhefgaksleecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhf

YEWADASKLPEYMLDMRASIKLQYIRSSKKTGVCIGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
|||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
yewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmk

FAVTTGVVHDAAIGEKPKPQKSIVGKGPKSGF
||||||||||||||||||||||||||||||||
favttgvvhdaaigekpkpqksivgkgpksgf

subfamily_PTPN1_pd Subfamily PTPN1 68-174 7.7e-15 49.4 In-house 10-113 (290) alignment
Range on Protein: 68-174
Range on HMM: 10-113/290.0
ELLNQMHTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGkdDFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDID
|......  |  .| .  |. .| ..||   .  .||||..|  .|   |. ||| |.    |  ||..| |.  .|   ||.|| |.|   ....  . 
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlp.ntvdhfWqmvWeqkskavvmlnkvv

EKQKRKA
||.. | 
ekeqikc

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 70-173 1.3e-08 29.3 In-house 19-123 (307) alignment
Range on Protein: 70-173
Range on HMM: 19-123/307.0
LNQMHTSAMTYPN--TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDID
 ....  |   |.  | . |  | | ||   . | |..|. .  .    |.  | ..    |   .| || |  . | | || |. . |   .... .. 
vdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgpl.entqysfwamaiqekvesvimlckvi

EKQKRK
|  | |
elakik

0045450 (Phosphotyrosine protein) phosphatases II 71-356 2.8e-42 140.9 In-house 37-302 (307) alignment
Range on Protein: 71-356
Range on HMM: 37-302/307.0
NQMHTSAmTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWV--------DGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSM
.....    .. .. ....|.|.||... ...||.|| | . ||.   .|..|||.|        ||| .| ..| .|.| .. | . ||||. | . ..
lsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.tvedFwrmlweqgvtv

ILVFGDIDEkqkrkapydisdrgfeksflhefgaksleeceLKAKICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVT---EKKQDHQTVLMHF
|.   . .|                                |. ..| ..||..|... .  . .   . . . ... ..|.||   .... ..   .|.
ivmltelve................................lgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

YEWADASKL--PEYMLDMRASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHR---VGFKETMSAIKMQRFGCFRTVGPYSTAC
..| | .    .| .||.   ..  . ...|.     ||..  |  ||  .. ....... ... .|.    | . |... ...|| |.. . . |   .
tgwpdhgvppsfeelldfieevrkaleelpkg.....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

EMLMK
|.|..
ealle

0046845 (Phosphotyrosine protein) phosphatases II 74-361 1.6e-44 147.8 In-house 12-277 (284) alignment
Range on Protein: 74-361
Range on HMM: 12-277/284.0
HTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWVDGY-----SKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGD
 |  .... .. ....|...|| ......||||| | . ||.   .|..|||.||||      .| ..| .|.| .. | . ||||| | . ..| .. .
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvweqnvrvIVmlte

IDEKQKRKapydisdrgfeksflhefgaksleecelkakiCRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTE---KKQDHQTVLMHFYEWADA
..|... |                                | ..||..|... .  ...   . . . ......|..|    ... ..   .|. .| | 
lvengrek................................caqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdh

SKL--PEYMLDMRASIKLQYIRsskktGVCIGPIMLVCATGVEKCAIYATIDIIVSRITEEH---RVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
.    || .|..   .. .. .       . |||.  |  || . . ....|.. ... .|.   .| . |... ...||.|.. |.  |   .|.|. .
gvppspedlleflrlvrellen.....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley

AVTT
. ..
lklk

subfamily_PTPRG_pd Subfamily PTPRG 74-174 1.9e-20 67.6 In-house 31-133 (563) alignment
Range on Protein: 74-174
Range on HMM: 31-133/563.0
HTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQ
.| ... . .  .  .|   ||   .  .|.|||.|.|  ||    |. ||...||| |. |.| .| | .| |   ||||. |.. ..| .  .. |..
etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkd.tfddFWrmiWeqnvaiivmitnlverg

KRKA
.|| 
rrkc

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 74-170 6.9e-11 36.5 In-house 24-119 (287) alignment
Range on Protein: 74-170
Range on HMM: 24-119/287.0
HTSAMTYPNTYDkfLNNMDMNRIPHLYCFDHSRVELA--PQDGKdDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVF-GDIDEKQ
..|..|. .. .  | ..  ||  ..  .|..|| |.  .. |  |. || .| .| .. |.| ||.|.   |   |||.| |.. . ...   ...| .
esstatfkaaee..laavkknryadvlPiddtrvllsaegelGs.dyinanyvasytddeafiaaqgPiaa.tvrdfwravletrsasvitmtreveear





subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 74-137 7.3e-08 26.5 In-house 30-94 (95) alignment
Range on Protein: 74-137
Range on HMM: 30-94/95.0
HTSAMTYPN--TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDgKDDFYNASWVDGYSKKSAYIFAQ
.. .||     |      |.  ||.  .. .| .|| |. .    |. || .||||..| .|| ||
ksismtsgapytvgsseanipknrflnifpydatrvvlttkr.dsdyinacfvdgyarkncyiaaq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 75-176 1.9e-12 41.9 In-house 36-136 (297) alignment
Range on Protein: 75-176
Range on HMM: 36-136/297.0
TSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKksAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKR
 .|...|.|  .   |.. .|      .| |||.||  . .   |. |||.| |. .   .|  | | .. |   ||.|| . ..|.|..  | .|..|.
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka.tvadfWamvldeqvstivmlnddnerdkk

KAPY
 | |
cary

DSPc_SM00195 76-357 4.8e-58 191.9 In-house 12-261 (263) alignment
Range on Protein: 76-357
Range on HMM: 12-261/263.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKqkrk
|. . . |  .. .|...||  . ...||.||.| ....  ..|..||....|..||..||..|.|. ..|   |||||.|.| ..|... . .|.    
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeen....

apydisdrgfeksflhefgaksleecelKAKICRKFWPEK-GSKKDFPALSIQASDDHS---ETHMKTFNLTVTEKKQDHQTVLMHFYEWADAsKLP---
                            . . | ..|||. |.|..|  .|..  . ..   |....|..|| ..|......  ... .| |  ..|   
............................gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdst

EYMLDMRASIKLQYIRSskktgvcIGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
...|..  ..| .. .|        |||. .| .||.......|||||.|...||..| ..|.......||.|...|   |....|.....
ksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 76-357 4.8e-58 191.9 In-house 12-261 (263) alignment
Range on Protein: 76-357
Range on HMM: 12-261/263.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKqkrk
|. . . |  .. .|...||  . ...||.||.| ....  ..|..||....|..||..||..|.|. ..|   |||||.|.| ..|... . .|.    
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeen....

apydisdrgfeksflhefgaksleecelKAKICRKFWPEK-GSKKDFPALSIQASDDHS---ETHMKTFNLTVTEKKQDHQTVLMHFYEWADAsKLP---
                            . . | ..|||. |.|..|  .|..  . ..   |....|..|| ..|......  ... .| |  ..|   
............................gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdst

EYMLDMRASIKLQYIRSskktgvcIGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
...|..  ..| .. .|        |||. .| .||.......|||||.|...||..| ..|.......||.|...|   |....|.....
ksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

0039614 (Phosphotyrosine protein) phosphatases II 76-357 3.1e-42 140.4 In-house 42-288 (297) alignment
Range on Protein: 76-357
Range on HMM: 42-288/297.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWVDGYSK-KSAYIFAQAPfNDHTEYVFWRMVSERKPSMILVFGDIDEKQk
  .. . .. .. .|.|.||... ...||||| | | ||    .|..|||.||||.. . ..| .|.| ...| . ||||| | . ..|.   . .|.. 
lslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP.lpetvedFwrmvweqgvtvivmLtklvelg.

rkapydisdrgfeksflhefgaksleecelkaKICRKFWPEKGSkkDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKL--PEYM
                                . | ..|||.|.   .  ...   . . . ......|.|| ... ..   .... | | .    .|..
................................rkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslell

LDMRASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|..   .. .. ...|.     ||.   |  || ... ........... .|..| ..|... ...|| |.. | . |   ...|...
leflelvrealaelpkg.....gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel

subfamily_PTPN12_pd Subfamily PTPN12 76-174 1.4e-13 45.4 In-house 26-125 (290) alignment
Range on Protein: 76-174
Range on HMM: 26-125/290.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRK
.  .|...  .  .|.  ||   .  .|.|||||  .....  |. ||... | ..| .|| ||.|.  .|   ||||. | . .....   . | .| |
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLp.ktlddfWrmiweknveivvmaCrevelgkkk

A
 
C

0040438 (Phosphotyrosine protein) phosphatases II 78-387 8.9e-46 152.0 In-house 31-304 (317) alignment
Range on Protein: 78-387
Range on HMM: 31-304/317.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKap
  .. .. ....|.|.||.|. ...||||| | | .|   .|..|||.|||...| ..| .|.|  ..| . ||||| | . ..|. . . .|....|  
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.pntvedFwrmvweqgvtvivmLteleelgrek..

ydisdrgfeksflhefgaksleecelkakiCRKFWPEkGSKKDFPALSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWADASKL--PEYMLD
                              | ..||. |... .  ....  . . . ... ..|.|.  .... ..   .|.  | | .    |. .||
..............................caqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

MRASIKLQYirsS--KktgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAvTTGVVHDAAI
.   .. ..   .  .      ||..  |  || ... ........... .|..| ..|..  ...|| |.. | . |   ...|...  .....   | 
fleavreal...edpg......gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.krkltlepas

GEKPKPQKSIVGKGPKSG
  | |..|  . . ... 
elklkllklliplalddv

0051299 (Phosphotyrosine protein) phosphatases II 78-357 1.6e-44 147.9 In-house 37-285 (288) alignment
Range on Protein: 78-357
Range on HMM: 37-285/288.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKap
.... .. .. .|.. || ......||||| | . ||   .|..|||..||| .| ..| .|.| .. | . ||||| | . ..| .. ...|....|  
pdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn.tvedFWrmvweqnvrvIvmltklvelgrek..

ydisdrgfeksflhefgaksleecelkakiCRKFWPEkGSKKDFPALSIQASDDHSETHMKTFNLTVT------EKKQDHQTVLMHFYEWADASKL--PE
                              | ..||. |... .  ...   . ... ......|.||       ... ..   .|.. | | .    ||
..............................caqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

YMLDMRASIKLQYIrsskktgVCIGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
 .||.   .. ..         . ||..  |  || ... ....|...... .|..| . |..  ...||.|.. |.  |   .|.|. .
llldflrlvrkala.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

subfamily_PTPRB_pd Subfamily PTPRB 78-173 1.5e-15 52.0 In-house 39-135 (293) alignment
Range on Protein: 78-173
Range on HMM: 39-135/293.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRK
..   . ..   | . ||   .  .|||||.||.   . ..|. ||....||. .  .| .| |. . |   ||||| |.| |.|... .. || | |
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe.tvddfWrmvwekkssiivmltqlvekgkvk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 78-168 3.8e-08 27.6 In-house 23-111 (285) alignment
Range on Protein: 78-168
Range on HMM: 23-111/285.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDgkDDFYNASWVDGYSK-KSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDE
|    ||  .  | |.||   . | . .|| |  .|   |.  |||.    | .|.|| .| |. . |   ||.|. . | . .|..  . |
mppnctytayeanpdlnryadvrcieetrvvlknhd..rdyihaswmrmpgkdqstyittqgplpe.tlsdfwhmiyqekiayvlmlctlfe

0036941 (Phosphotyrosine protein) phosphatases II 79-362 4.9e-48 159.3 In-house 28-281 (297) alignment
Range on Protein: 79-362
Range on HMM: 28-281/297.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKapydi
 .. .. ....|...|| .. ...||.|| |  .|...|..|||.||||. | ..| .|.| .. | . ||||| | . ..|... . .|... |     
lgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpn.tvedFWrmvweqnvtvIvmltelvelgrek.....

sdrgfeksflhefgaksleecelkakiCRKFWPEK-GSKKDFPALSIQASDDHS--ETHMKTFNLTVTE--KKQDHQTVLMHFYEWADASKL--PEYMLD
                           | ..||.. |. . .  ....  . ..  ........|.||   ... ..   .|.  | | .    |...||
...........................caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslld

MRASIKLQYiRSSK-KtgvciGPIMLVCATGVEKCAIYATIDIIVSRIT---EEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVTTG
.   .. .. . .  .     ||..  |  || ... ....|......    .|..| ..|..  ...||.|.. |.. |   .|.|...  .. 
fielvrkvl.kllpsg.....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0047943 (Phosphotyrosine protein) phosphatases II 79-356 3.6e-45 149.9 In-house 27-270 (273) alignment
Range on Protein: 79-356
Range on HMM: 27-270/273.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKapydi
 .. .. .. .|.|.||.......||||| |  .||..|..|||.|||| .| ..| .|.| .. | . ||||| | . ..| .  ...|....|     
lltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpn.tvedfwrmvweqnvrviVmLtelvelgrek.....

sdrgfeksflhefgaksleecelkakiCRKFWPEKGS--KKDFPALSIQASDDHSETHMKTFNLTVTE--KKQDHQTVLMHFYEWADASKL--PEYMLDM
                           | ..||..|   .. .  ...   . ... ......|..|    .. ..   .|...| | .    .|..|..
...........................caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef

RASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
   .. ..  . ..     ||..  |  || . . ....|...... .|..| ..|..  ...||.|.. |.  |   .|.|..
ielvrkalealpsn.....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0050432 (Phosphotyrosine protein) phosphatases II 79-358 1.1e-43 145.1 In-house 57-299 (308) alignment
Range on Protein: 79-358
Range on HMM: 57-299/308.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELapqDGKDDFYNASWVDGY--SKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKapy
 .. .. .. .|.|.|| .. ...||||| |   |...|..|||.||||   .. ..| .|.| .. | . ||||| | . ..| .. ...|... |   
lleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpn.tvedFwrmvweqnvrvIvmLtklvengrek...

disdrgfeksflhefgaksleecelkakiCRKFWPEK--GSKKDFPALSIQASDDHSETHMKTFNLTVTE--KKQDHQTVLMHFYEWADASKLP--EYML
                             | ..||..  |. . .  ...   . ... ......|..|   ... ..   .|.  | | .  |  | .|
.............................caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

DMRASIKLQYirsSKktgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
|.   .. ..   ..      |||.  |  || ... ....|...... .|..| . |..  ...|| |.. |.  |   ...|....
dflelvrksl...pg......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 79-338 1.7e-17 57.9 In-house 34-216 (392) alignment
Range on Protein: 79-338
Range on HMM: 34-216/392.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQkrkapy
 ||.|  .   |.  ||      .| .|| |    .  ..|..|||.....  . ||| .|.|    .   ||||| . ... | .  ...| .      
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa.slddfwrmvfqenvttiamvtklkegd......

disdrgfeksflhefgaksleecelkakicrkfwpekgskkdfpalsiqasddhsethmktfnltvteKKQDHQTVLM-HFYEWADASkLPEYmldmrAS
                                                                    | .|..||   || || |.  .|..     .|
....................................................................kgddartvaqfhftewPdkd.vpkh.....ts

IKLQYIRS-SKKTGVCIGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRF
  |..|.  . . |    |... |..|| . ..  .|| .|..  . . |   . .. |. .| 
sllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 79-173 5.6e-15 50.0 In-house 35-132 (290) alignment
Range on Protein: 79-173
Range on HMM: 35-132/290.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKDD----FYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRK
 .  |..   .|   ||  ..   |  |. | |  |. |    . ||....||..| .|| .|.| . .|   ||... ..| ..|..  .| |..| |
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs.ntlvdFWkliwqekvtiivmltniieegkvk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 79-202 1.1e-12 42.4 In-house 33-154 (315) alignment
Range on Protein: 79-202
Range on HMM: 33-154/315.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPY
.|...  .  .|.  ||      .|..|| |    .. ..|..||| . .. .  ||| .|.| .  .   ||||| . |.. | .  . .|  | |   
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka.svddfwrmvlqekvttivmvtkkqegdkikcrq

DISDRgfeKSFLHEFGAKSLEECELK
   ||   |. . |||. ..|  .|.
ywPdr...kadsvefGsikvellsle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 79-173 2.8e-11 37.2 In-house 32-127 (515) alignment
Range on Protein: 79-173
Range on HMM: 32-127/515.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQKRK
 ||.|  .   |   ||      .| .|| |    .. . |..||| . ..    ||| .|.| .  ..  |||.| . ... | .  .  |  | |
iypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd.dfWrlvlqenvttiamvtklkegdkik

0040439 (Phosphotyrosine protein) phosphatases II 81-356 9.7e-41 135.4 In-house 2-244 (249) alignment
Range on Protein: 81-356
Range on HMM: 2-244/249.0
PNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPfNDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKapydi
. .. ....|.|.||.|. ...||||| | . .|   .|..|||..|||  | ..| .|.|  ..| . ||||. | . ..|. . . .|... |     
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP.lpetvedfwrmlwelgitvivmLtslvelgrek.....

sdrgfeksflhefgaksleecelkakiCRKFWPEkGSKKDFPALSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWAdASKLPEYMLDMRASI
                           | ..||. |. . .  ....  . ... ......|..|  .......   .... |    ..|... |. . |
...........................caqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfi

KLQYIRSSKK-TGvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
..     ..  .|   ||..  |  || ............... .|..| ..|... ...||.|.. . . |   .|.|..
eavrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

0045098 (Phosphotyrosine protein) phosphatases II 81-355 3.4e-28 94.2 In-house 24-269 (278) alignment
Range on Protein: 81-355
Range on HMM: 24-269/278.0
PNTYDKFLNNMDMNRIPHLYCFDHSRVElapqdgkdDFYNASWVDGYskKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQkrkapydisd
  |.  .|.|.|.||... ...|||||         |. |||..|||  . ..| .|.|.. .|   ||||. | . . |.   .  |..          
eitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlp.stvadfwrmlwelgitvivmltelvelg..........

rgfeksflhefgaksleecelkAKICRKFWPEkGSKKDFPALSIQASDDHSETHMKTFNLTVT------EKKQDHQTVLMHFYEWADASKLPEY----ML
                       . | ..||| |. . .  ...   . .   .. .  |.||      |  . .    .|.. | | .  ..     .|
......................rekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfl

DMRASIKLQYIRSSKK---------TGvciGPIMLVCATGVEKCAIYATIDIIVSRIteEHRVGFKETMSAIKMQRFG-CFRTVGPYSTACEMLM
..   |.  . .  ..          |   ||.   |  ||   . .. .... ...  |..| . |. . ...|| | .. . . |   .|.|.
ellefirealkllaslllsslllldsg...gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 82-342 3.1e-30 100.6 In-house 53-275 (319) alignment
Range on Protein: 82-342
Range on HMM: 53-275/319.0
NTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGdidekqkrkapydis
 |.    .| | ||| ..  ||...| | . .|..  |. |||.|.|| .|  || || |  | |   ||||. | . | |...                
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl.dntladfWrmiweyncstivllt...............

drgfeksflhefgaksleecelkAKICRKFWPEKGSKK-DFPALSIQASDDHSETHMKTFNLTVTEKKQDHQT-VLMHFYEWADASkLPEYMLDMRASIK
                        . | ..|| |. .| .   ..... .. .|  .. ..|.   |..| .     ||  | |    |.|  |.   .|
.......................kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvG.vpdypsdlmrlvk

L-QYIrSSKKTGVciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFR
  ...  ||. .    .|.. |..|| .  .| ..|....|. ||..|   ...  .. ||    .
kvrhl.tskenhr..anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvq

0049772 (Phosphotyrosine protein) phosphatases II 82-342 1e-15 53.7 In-house 39-258 (314) alignment
Range on Protein: 82-342
Range on HMM: 39-258/314.0
NTYDKFLNnMDMNRIPHLYCFDhSRVELAPQDGKD-DFYNASWVDGYskkSAYIFAQAPfNDHTEYVF----------WRMV--SERKPSMILV------
 ..|.||| .|.|| .. ...| .|| |  ..... |..|||.|||.    ..| .|.| ...| . |          ||||  ..... .|        
lvadlfln.rdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------FGDIDEKQkrkapydisdrgfekSFLHEFGAKSLEecelkakiCRKFWPEKGSKKDFPALSIQASDdH---SETHMKTFNLTVTE
               . ..|...               .....   . |.         . ..||. ..  .  | |  .| .   .. ... |   . |
adelsrLdaAlgKtpllildgng...............neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefiee

KkQdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvCIGPIMLVCATGVEKCAIYATIDIIVSRIteehRVGFKETMSAIKMQRFgCFR
  .                                            ||.   |. |.   . ..........     .| ..|... ....|. .  
a.d..........................................kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp.inp

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 82-174 6.5e-10 33.4 In-house 25-117 (283) alignment
Range on Protein: 82-174
Range on HMM: 25-117/283.0
NTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGkdDFYNASWVD---GYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
 . .   .|  .||  ..   |  |||| ..    |. ||...     | ..  || ||.|. |.|   ||.|| ..| . |...  . | .. | 
adiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPl.drtvvdfWkmvfdekitaivmltklqedlrikC

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 83-344 4.5e-30 100.1 In-house 18-241 (284) alignment
Range on Protein: 83-344
Range on HMM: 18-241/284.0
TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGdidekqkrkapydisd
|.    .| | ||| |.  ||...| | . .|..  |. |||.. || .|  || .| |  | |   ||||. | . | |...                 
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPl.dntladfWrmiweyncstivllt................

rgfeksflhefgaksleecelkAKICRKFWPEKGSKK-DFPALSIQASDDHSETHMKTFNLTVTEKKQDHQT-VLMHFYEWADASkLPEYMLDMRASIKL
                       . | ..|| |. .| .   ..... .. .|  .. ..|.   |..| ..   .||  | |    |.|  |. . .| 
......................kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvg.vpdypsdlmrlvkk

QYIRSSKKTGVciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTV
    .||. .    .|.. |..|| .  .| ..|....|. ||..|   ...  .. ||    . .
vrhltskenhr..anivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 83-175 1.5e-15 52.0 In-house 42-135 (315) alignment
Range on Protein: 83-175
Range on HMM: 42-135/315.0
TYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKAP
   |  .| . ||  .   .|.|||.|    .| . |. ||...|||.||  || ||.|    .   |||.| | . . |... .. |..|||| 
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva.svkdfwrlvfeedigkivmltnlvegekrkae

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 83-347 5.5e-13 43.6 In-house 36-260 (288) alignment
Range on Protein: 83-347
Range on HMM: 36-260/288.0
TYDKFLNNMDMNRIPHLYCFDHSRVELApqdGKDDFYNASWVDG-YSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKA-PYDISD
. |.|..|   .|  .|.. | .|| |       ||| |. |      |   | ||||. . |  ..|.|. |     |... .. || |.|.  |  | 
iidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPl.ngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

RGFEKSFLHEfgaksleecelkakicrkfwpekgskkdfpALSIQASDDHSETHMKTFNLTVTEKKQDHQ-TVLMHFYEWADASkLPE-YMLDMRAsikL
 | .  . .                                  .. . .  .  .|   | .... ....    .|. || | . .|| |.  .|    |
lGekarigrl..............................ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddg.vPenylsplrl...l

QYIRSSKKtgvcigPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
. ..| .|      ||.. . .|| ...  . | |..  .  .  .| .. ..  . .|| . .|   |
evlkslqk......PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqy

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 83-162 2.6e-11 37.7 In-house 40-113 (303) alignment
Range on Protein: 83-162
Range on HMM: 40-113/303.0
TYDKFLNNMDMNRIPHLYCFDHSRVELApqdgKDDFYNASWVDGYSKKSAyIFAQAPFNdHTEYVFWRMVSERKPSMILV
. ..|..||| ||.  . |.|||.|.|.       .  ||...  |.| | |..| |.. ||   ||.|. |.|   .|.
sknqfvknmdknrfvdvicldhskvkls....dssyihasyleldsskka.iltqlpls.htaadfwqmiieqkvkcvll

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 83-172 6.7e-11 36.3 In-house 45-134 (310) alignment
Range on Protein: 83-172
Range on HMM: 45-134/310.0
TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG-KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKR
||. . ..|  ||   . | | ||| |  .    .|.  | .|     .|..| .| |. .||   ||||. . .   ||..  . |. . 
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgpl.qhtiidfwrmifqeraesilllckvgeegrp

0042113 (Phosphotyrosine protein) phosphatases II 84-355 2.8e-39 130.4 In-house 3-240 (245) alignment
Range on Protein: 84-355
Range on HMM: 3-240/245.0
YDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKapydisdr
. ....|.|.||... ...||.|| | | .|   .|..|||.||||  .  .| .|.| .. |   ||||. | . ..|. . . .|... |        
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvk........

gfeksflhefgaksleecelkakiCRKFWPEkGSKKDFPALSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWADASKL--PEYMLDMRASIK
                        | ..||. |... .  ....  . ... ......|.||   ... .. . .|.. | | .    .|..||.   ..
........................caqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr

LQYIRSSKktgvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
 .. ..|.      ||..  |  ||  .. ........... .|..| . |..  ...|| |.. | . |    |.|.
kalaedsn......gpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_PTPN9_pd Subfamily PTPN9 84-174 3.3e-17 57.5 In-house 36-127 (297) alignment
Range on Protein: 84-174
Range on HMM: 36-127/297.0
YDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
. |   |.  ||   . |.|..|| || .|...  |. ||..|||| .| |.| .| |.. .|   ||||| |..  .|..   . |....| 
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplk.ktvsdfWrmvWeqevlvivmttrvvergrlkc

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 84-174 4.9e-17 57.0 In-house 40-131 (305) alignment
Range on Protein: 84-174
Range on HMM: 40-131/305.0
YDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
 .|  .|   ||  .   .|..|. |.... .|  |. |||.||||..| .|| ||.|... |   |||.. | |.| |. . .. | .| | 
vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn.tvadfWrliveekvstivmltklveggkdkC

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 84-162 1.7e-08 28.2 In-house 45-123 (302) alignment
Range on Protein: 84-162
Range on HMM: 45-123/302.0
YDKFLNNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEY--VFWRMVSERKPSMILV
   | .|...|. ... . |. .| |  .  .|...||| |.  . .   | || |  | ..    ||||| ..|  .. .
Ckafkknlkknqsedvpildsnlvkl..eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi

0037934 (Phosphotyrosine protein) phosphatases II 86-355 3.7e-25 84.3 In-house 6-239 (243) alignment
Range on Protein: 86-355
Range on HMM: 6-239/243.0
KFLNNMDMNRIPHLYCFDHSRVELapqDGkDDFYNASWVDGYSKksaYIFAQAPFNDhTEYV----FWRMVSERKPSMILVFGDIDEKQKRkapydisdr
....|.. || .. ...||||| |   .| .|..||...... .   .|  |.| .. |       ||||. | . ..|. . . .|...          
llpenlsknrysdilpydhsrvkl...eg.sdyinanliyvtpr...liatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgre.........

gfeksflhefgaksleecelkakICRKFWPekGSKkDFPALSIQASDDHSETHMKTFNLTVTE---KKQDHQTVLMHFYEWADASKLP-EYMLDMRASIK
                        | ..||  |..  .  ....  . ..  ... ..|...    ... .. .  |.. | | .  .    |    .. 
.......................kcaqywp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldev

LQYIRS-----SKKTGvciGPIMLVCATGVEKCAIYATIDIIVSRIteehRVGFKETMSAIKMQRFG-CFRTVGPYSTACEMLM
 ..|..       ..|   ||. . |  || . . ....... ...    .|.. |..  ...||.| .. | . |    |.|.
refieellsllaldsg...gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_PTPRD_pd Subfamily PTPRD 86-174 1.1e-19 65.5 In-house 44-133 (564) alignment
Range on Protein: 86-174
Range on HMM: 44-133/564.0
KFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
.   |   ||  .   .||||| | . .|  . |. |||..||| |. ||| .|.| .. |   ||||| |.. |.|     . ||.| | 
nkpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae.tiedFWRmvweqnsstiVmltkleEkgkvkc

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 86-175 2.7e-17 58.0 In-house 52-142 (298) alignment
Range on Protein: 86-175
Range on HMM: 52-142/298.0
KFLNNMDMNRIPHLYCFDHSRVELAP--QDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAP
.  .| . || . .  .|.||| |    .| . |. |||....|....|.| .|||.. .|   |||||.|.. . | .. .. |..| | .
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt.etvedFWrmvteedigtiVmltnleeldktkyh

subfamily_PTPN3_pd Subfamily PTPN3 86-173 6.2e-10 33.5 In-house 37-125 (280) alignment
Range on Protein: 86-173
Range on HMM: 37-125/280.0
KFLNNMDMNRIPHLYCFDHSRVELApqDGKDDFYNASWVD----GYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRK
.  .|.. ||   .  .|. ||.|   ... |. ||..|.    . .    || .| |.. .|   ||.|| |.| |.|... .. |. . |
rkpenlsknryrdilpydatrvklk..esetdyinanyvnmeipstglvnryiatqGPla.ktatdfWqmvweqksslivmlttlverGrvk

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 86-195 4.6e-08 27.1 In-house 39-146 (312) alignment
Range on Protein: 86-195
Range on HMM: 39-146/312.0
KFLNNMDMNRIPHLYCFDHSRVELApqdGKDDFY-NASWVDGYSKKSAYIFAQAPFNDHTEYvFWRMV-SERKPSMILVFGDIDEKQKRKAPYDISDRGF
 ||.  |.|| | . |.|  |  ||   | ..||  | .|   .|   .. .|.|... . . ||... |    |.||. | ...  .. | |     ||
aflkfkdlnrypniqcwdrgrftla...gdenfyihanfvkictkperfvctqgplentcth.fwqlalslgstsiillcgfvedgsekcakyisdivgf

EKSFLHEFGAKS
 .   |   ...
vdledhrvytey

subfamily_PTPN13_pd Subfamily PTPN13 86-171 2e-06 22.3 In-house 33-116 (273) alignment
Range on Protein: 86-171
Range on HMM: 33-116/273.0
KFLNNMDMNRIPHLYCFDHSRVELAPQDGkddFYNASWVDGYSK--KSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQK
|  .|.| ||  ..  .|..||.|  . |   . |||..       .  || .| |. . ..  ||.|| |.| ..| .     ||.|
kkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvk.dfwqmvweqkaeviamvtlekekgk

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 87-165 1.9e-15 51.8 In-house 38-117 (281) alignment
Range on Protein: 87-165
Range on HMM: 38-117/281.0
FLNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGD
  .|.  ||   .  .|..||...|.  . . |. ||..|.||... .|| .|.|  . . . ||.|| |.| |.| .   
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPa.slvafWqmvweqkvsaivmvtr

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 87-173 4e-11 37.4 In-house 17-105 (270) alignment
Range on Protein: 87-173
Range on HMM: 17-105/270.0
FLNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWVDGYSK-KSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRK
. ..  .||   .    ..|| |..   | .  ..|| .| |... | .|| |..|  . |   ||||. |.| . |..  .. || ..|
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPl.pttlksfwrmiweekvtaivmttgleEkgrkk

subfamily_PTPRA_pd Subfamily PTPRA 88-174 7e-19 62.9 In-house 56-143 (330) alignment
Range on Protein: 88-174
Range on HMM: 56-143/330.0
LNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
 .|.. ||....  .|.||| |....|..  |. |||..||| .|  .| || | . .|   ||||. |.| . |... ...|... | 
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke.etvedfwrmiweqksativmltelkerkeekc

subfamily_Ptp69D_pd Subfamily Ptp69D 88-174 3.7e-18 60.7 In-house 47-133 (307) alignment
Range on Protein: 88-174
Range on HMM: 47-133/307.0
LNNMdMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
 |..  || ...  ||. || |..  ||.  |. |||.. || .|  .| ||.|  . |   ||||..| .  .| .  ...||...| 
enal.knRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv.eatigDfWRmiaeqevtlivmlsnlteknrkkc

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 88-173 7.3e-17 56.4 In-house 46-132 (319) alignment
Range on Protein: 88-173
Range on HMM: 46-132/319.0
LNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQKRK
 .| . || . .  .|..|| |.. ||..  |. |||..||| .....| .||| .. .|  ||||| |.. |....  .. || | |
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentie.dfWrmvWeeessivvmltklveklkvk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 88-176 1e-15 52.7 In-house 7-96 (250) alignment
Range on Protein: 88-176
Range on HMM: 7-96/250.0
LNNMDMNRIPHLYCFDHSRVELAPQD--GKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQKRKAPY
..| . ||  ..  .|.||| | ...   . |. |||...||....|.| .|.|... .|  ||||| |.| . |... .. |..|    |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatie.dfWrmvleeksgtivmLtnLkesektyhqy

subfamily_PTPRK_pd Subfamily PTPRK 88-173 1.1e-14 49.1 In-house 41-127 (314) alignment
Range on Protein: 88-173
Range on HMM: 41-127/314.0
LNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRK
 .| . ||. ..  .|.||| | . ||    |. ||...|.| . .|.| .| | .. | . |||.| . . . |..  .. |... |
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe.tvkdfWrlvydencasivmltelvevgrvk

subfamily_CG7180_pd Subfamily CG7180 88-170 1.3e-13 45.3 In-house 40-123 (296) alignment
Range on Protein: 88-170
Range on HMM: 40-123/296.0
LNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQ
..|.. || ..   .|. || |   ||.  .|. ||..||.. || .||  .|| ..  .  |||.| ... | . |  .  . .
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvd.efWrlvydeeisavvvLtktfdfa

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 88-173 4.2e-13 44.0 In-house 45-131 (288) alignment
Range on Protein: 88-173
Range on HMM: 45-131/288.0
LNNMDMNRIPHLYCFDHSRVELAP--QDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQKRK
 .| . || .    .|. ||.|    .  . |. |||..||. || .|| .|.|  |  .  ||..| |.| | |. . .. |..|.|
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn.dfWelvyenktstivmltelveggktk

subfamily_PTPN14_pd Subfamily PTPN14 88-175 2.3e-12 41.5 In-house 47-136 (300) alignment
Range on Protein: 88-175
Range on HMM: 47-136/300.0
LNNMDMNRIPHLYCFDHSRVELAPQ-DGKDDFYNASWVDG--YSKKSAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAP
 .| . ||....  ....||||.|. . .... ||| .     .|.  || ||.|  ..|   ||.|| | . ..|.   .. |. | |. 
penaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl.eltvqdfWqmvWeqgvqlivmlteeeedgkeksf

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 88-174 1e-09 32.9 In-house 26-115 (274) alignment
Range on Protein: 88-174
Range on HMM: 26-115/274.0
LNNMDMNRIPHLYCFDHSRVELAPQDGKDD---FYNASWVDGYSKK-SAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
  .   ||   .   ..||| | .....|.   . || .. ||...  ||. .| |.  .|   ||||. ... ..|..  .. |....| 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlp.ntvadfWrmiyqeevqvivmltklkeaneqkC

subfamily_egg_pd Subfamily egg 88-215 1.3e-09 32.2 In-house 38-132 (307) alignment
Range on Protein: 88-215
Range on HMM: 38-132/307.0
LNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKqkrkapydisdrgfek
 ||..  | ... | | |||.|  . |.  |||  |  |.|      .| ||||. . |   ||||| . .   |...    |                 
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkn.tvddfwrmvfqeevqyivmltsrkes................

sflhefgaksleecelkaKICRKFWPEKGS
                  . |  .||   |
..................erceyywpkaes

subfamily_eak_pd Subfamily eak 88-357 3.4e-09 30.6 In-house 50-304 (332) alignment
Range on Protein: 88-357
Range on HMM: 50-304/332.0
LNNMDMNrIPHLYCFDHSRVELAPQ-DGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTeYVFWRMVSERK-PSMILVFGDIDEKQKRKAPYdISDRGFEK
|.... | . ..  .|.  |.|..    .. . ||| ..       ||.. .. .|.  ..||.|| |.| |... .  |...| ..   |   |.. |.
leavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkv.fafwqmvleqkspaivqlledvelkleksdky.fpdktree

sflHEFGAKSLEecelkakiCRKFwPEKGsKKDFPALSIQ-ASDDHSETHMKTFNLTvtEKKQDHQTVLMHFYEWADASKLPeYMLDMRASIKLQYIRSS
    .||   .|        ...|  ... . ..  | ..   . |   | | |  |  | .      .. ...       .  .. |....   ...  
...lkfGildve........rkef.vkrn.iletrllelskGnethrvlhykvfGwt..ettlpkyedflalrkvmkevGvl.llivmksallsstlkky

KKTGVCIGPIMlVCATGVEKCAIYATIDIIVSRITEEHRVG--FKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
..|  .  ||.  .|.|  .. ..  ||...  | .  .     .. .  .| .|  .  .   .|   |.....
ihtppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy

subfamily_PTPRN_pd Subfamily PTPRN 88-183 3.6e-09 30.7 In-house 54-151 (297) alignment
Range on Protein: 88-183
Range on HMM: 54-151/297.0
LNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWV-DGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRGF
 .|.. ||  ..  .|||||.|  .  . |.|. ||| . |   ...||| .|.| . .|   ||.|| |.   .|. .  ..|.. ..      | | 
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpla.stvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 89-355 1.2e-17 58.5 In-house 39-290 (301) alignment
Range on Protein: 89-355
Range on HMM: 39-290/301.0
NNMDMNRIPHLYCFDHSRVELAPQDG----KDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRGFE
.|  .||  .   .|. |. |.|.      . .. |||..||||.| ..| ||.|.. .|   |||.. . ||. |..  . .|..| |.    ..   |
enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmk.ktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

KSFLHEFGAKSLEECELKAKICRKFW--PEKGSKkdfpalsiqasddhsE-THMKtfNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRaSIKLQYI
..   .|  .  .|. .   . |..    ..||.               .   ..  .. |...|. .. . ..  .| .   ..|.   .. .|  . .
seefgpftvtlvneqvyPdfvirqlnvkiqdgsn...............ngyier..kfkvksdksswdvlqlqvtdWpqdGvvreprtvLq.viddvih

RSSKKTGvciGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
|  |  |   ||..  |  .| .  .| ...| .     |  |   .   |.. .. |   |   |..  ... 
rqqkigg...gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 89-173 2.9e-15 51.0 In-house 46-127 (287) alignment
Range on Protein: 89-173
Range on HMM: 46-127/287.0
NNMDMNRIPHLYCFDHSRVELApqDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRK
.| | ||. ..   |  || |   . ..|. ||...|||..| |.| |..|  . |   ||... .|... |..  .  |.....
qnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfn.tarnfWkliddrnvtaivmlcqekendeev

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 89-182 3.4e-15 51.0 In-house 47-141 (325) alignment
Range on Protein: 89-182
Range on HMM: 47-141/325.0
NNMDMNRIPHLYCFDHSRVELA--PQDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRG
.|.. || . .  .|.||| |    .|.. |..|||..  . ||  .. ||||   .|   .||.| . . |...|   .|....| | |   . |
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlt.atindlWrlvldWrcsvvvvlneldlgkdrcavywpkemg

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 89-163 7.7e-11 36.5 In-house 32-103 (267) alignment
Range on Protein: 89-163
Range on HMM: 32-103/267.0
NNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVF
.| ..||. .   .|..|| |  .. .... |||.|.|| .| |.|  | |..  |   |. .. ..| ..| . 
knqernrlddnlpyddtrvil..rtkeeeyinasyvegyktknafivtqdplkn.titdfltvihdqkvpvivll

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 89-170 1.4e-09 31.9 In-house 95-175 (244) alignment
Range on Protein: 89-170
Range on HMM: 95-175/244.0
NNMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQ
||   ||      || .|| |.     . . |||.|    . . ||..| |. | |   ||.|. ||.  ...|.| ..|..
nnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhplad.tsmdfwkmmlerhvnvlvvlgsveeed

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 89-174 1.5e-07 25.4 In-house 53-136 (290) alignment
Range on Protein: 89-174
Range on HMM: 53-136/290.0
NN--MDMNRIPHLYCFDHSRVELApqDG-KDDFYNASWVDGYskKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
.|  .  ||   . | | .|| |   || . |.  | .|.|   |. .|..| . .| |   .|||| . | ..| .. .. |. | | 
kntefkknrykdvvcndktrvilk..dGydGdyvhanyvkGl..kamfiltqGalkd.tvidiwrmvlqekvaaivmlceliedGkakc

subfamily_ptpA1_pd Subfamily ptpA1 89-170 3.7e-06 20.9 In-house 46-127 (418) alignment
Range on Protein: 89-170
Range on HMM: 46-127/418.0
NNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKsAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQ
 |   ||   .   .|.||.|   . |   |. || ..||   |  .| .| |. . |   ||||| | .  .|...    |. 
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpn.tiadfwrmvwenrcriivmlsresenc

Y_phosphatase Protein-tyrosine phosphatase 90-175 1.4e-20 69.1 Pfam-A 1-85 (235) alignment
Range on Protein: 90-175
Range on HMM: 1-85/235.0
NMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAP
|.. || ..  ..|..||.|  ..|. |..||..|.||..|...| .|.| . .|   ||||| ..| ..| .  . .||...| .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekca

Y_phosphatase Protein-tyrosine phosphatase 90-175 1.4e-20 69.1 In-house 1-85 (235) alignment
Range on Protein: 90-175
Range on HMM: 1-85/235.0
NMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAP
|.. || ..  ..|..||.|  ..|. |..||..|.||..|...| .|.| . .|   ||||| ..| ..| .  . .||...| .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekca

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 90-174 1.3e-17 58.8 In-house 46-131 (318) alignment
Range on Protein: 90-174
Range on HMM: 46-131/318.0
NMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKA
|   ||   .  .||.||.| ...|.   |. ||...||| .| ||| ||||  . |   ||||| |.. ..|... .. |. |.| 
nkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe.tieDfWrmvWeqnsavivmltqeeergkakv

0041856 (Phosphotyrosine protein) phosphatases II 90-347 4.6e-13 44.6 In-house 1-160 (182) alignment
Range on Protein: 90-347
Range on HMM: 1-160/182.0
NMDMNRIPHLYCFDHSRvelapqdgKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGdidekqkrKAPYDIsdrgfeksflh
|.| || .. ...||||          |. ||....|. . . .| .|.| .. | . |.||. |.. ..|.             .|.            
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgplls.tvadflrmlkelgittivnlt........eelywp...........

efgaksleecelkakicrkfwpekgskkdfpalsiqasddhsethmktfnltvteKKQDHQTVLMHFYEWADASKLPeymldmrASIKLQYIRSSKKtgv
                                                       ..  .. .  ... | | .  .        .. |..|.  ..   
.......................................................ellerlgiqylylpwpDhgvpd.......ldelldfieevle...

CIGPIMLVCATGVEKCAIYATIDIIVSRiteehRVGFKETMSAIKMQRFGCFRTVGPY
  ||.   |  || . . .. .... ..     .|.. |... ....|.|.. |   |
eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqy

subfamily_PTPN23_pd Subfamily PTPN23 90-173 6.2e-12 39.9 In-house 43-124 (288) alignment
Range on Protein: 90-173
Range on HMM: 43-124/288.0
NMDMNRIPHLYCFDHSRVELApqDGKDDFYNASWVDGYSKKS-AYIFAQAPFNdHTEYVFWRMVSERKPSMILVFGDIDEKQKRK
. . ||   .  .||.|| |   ..|||. |||.| . |  .  .| .||| .  |   ||.|| |.| |.| .  . .|..| |
yseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlq.stlnDFWlmvyeqkssviVmllskeelgkpk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 90-173 3.3e-07 24.7 In-house 8-94 (239) alignment
Range on Protein: 90-173
Range on HMM: 8-94/239.0
NMDMNRIPHLYCFDHSRVELA--PQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTeYVFWRMVS-ERKPSMILVFGDIDEKQKRK
|   ||   .  .||||| |    .| . |. |||..  |     ||| .|   .  .   ||||.  ||.  .... | |. ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveiss.gdfwrmmwqerrcvivmltglieghkkkc

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 90-173 3.5e-07 24.6 In-house 7-93 (239) alignment
Range on Protein: 90-173
Range on HMM: 7-93/239.0
NMDMNRIPHLYCFDHSRVELA--PQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTeYVFWRMVS-ERKPSMILVFGDIDEKQKRK
|   ||   .  .||||| |    .| . |. |||..  |     ||| .|   .  .   ||||.  ||.  .... | |. ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveiss.gdfwrmmwqerrcvivmltglieghkkkc

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 91-173 2e-09 32.0 In-house 4-86 (237) alignment
Range on Protein: 91-173
Range on HMM: 4-86/237.0
MDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQKRK
   ||   . ..||||| |    .. |. ||....|.      || || |..   .  ||.|| . | |.|...  . |... |
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscd.dfwqmvwqekcsvivmltgliegnelk

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 91-195 6.6e-07 23.4 In-house 51-153 (301) alignment
Range on Protein: 91-195
Range on HMM: 51-153/301.0
MDMNRIPHLYCFDHSRVELApQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRGFEKSFLHE
 | .| |.. |  .. ||.  .|||     | |..   .   .| .|.|... | . || |.   .   | ..|   ||...|  . .. .  ||  .  
kdkhryptvPckPstavevi.vdGkrvPihanwiptsGhphrfiatqgPlkn.tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

FGAKS
|  | 
fkiki

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 92-171 5.8e-12 39.8 In-house 50-130 (439) alignment
Range on Protein: 92-171
Range on HMM: 50-130/439.0
DMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQK
  ||   .  |||.|| |   |   .  ..|| ...|| ..  || .|.| .. |.  |||.| |.| . |... .. |  |
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettd.dfwrlviekktvtivmltnlvesyk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 93-318 8.8e-07 22.9 In-house 50-289 (350) alignment
Range on Protein: 93-318
Range on HMM: 50-289/350.0
MNRIPHLYCFDHSRVELA----PQDGK------DDFYNASWVDGY----SKKSAY--IFAQAPFNDhTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPY
 ||   .  ..||||.|     . |.|      .|. ||...       . .. .  | .|||    |   |.... . |  .||   . .| . .|   
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlps.tvddfykvillnkvkvilsltsdvelnlekcyr

DISDRGFEKSFLHEfgaKSLEECELKAKICRKFwpEKGSKKDFPaLSIQASDDHSETHMKTfNLTVTEKKQDHQTVL-MHFYEWADASKL--PEYMLDM-
   . ....  ..    .|  |    .. . ..    . ||...      |||.   . .. .  .|    |   |. ...  | | | |  || .| . 
YWqegsydditvkl...askwenimgindssly..sadvkkeas.dndnisddndlkdnns.ltaitlaasdPyvvyqlqvknWkDlslllnPesilqal

--RASIKLQYIRSSKKTGVCIGPIMLVCATGVEKCAIYATIDIIVSRI
  .  .  . .  |        ||.  |. || .  .. |.| ..| .
evkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf

subfamily_CG42327_pd Subfamily CG42327 109-176 1.9e-08 28.3 In-house 49-117 (319) alignment
Range on Protein: 109-176
Range on HMM: 49-117/319.0
LAPQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQ-KRKAPY
  ..| || . .||.| || . .. || ||.. .| .   |||.| |..  .|.   |. |.  |. | |
rigdddkdeyldasyvrGyddapnsyiaaqvsledsss.dfwrtvweqqsrvivqltdlselGikvcaey

0043147 (Phosphotyrosine protein) phosphatases II 114-345 1.2e-09 33.6 In-house 3-148 (172) alignment
Range on Protein: 114-345
Range on HMM: 3-148/172.0
GKDDFYNASWVDGYSKKSAYIFAQAPfNDHTEYVFWRMVSERKPSMILVFGDIdekqkrkapydisdrgfeksflhefgaksleecelkakicrkfwpek
. .|..|||..|.| .   .|  |.|  ..|   ||||. |.. ..|.   .                                                
egsdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltel...............................................

gskkdfpalsiqasddhsethmktfnlTVTEKKQDHQTVLMHFYEWADASK-LPEYMLDMRASIKLQYIRSSKktgvciGPIMLVCATGVEKCAIYATID
                           ... ..  .. .  ... | | .  |.|..|..   |.  ...|..      ||.   |  ||   .  . ..
...........................lydpellerlgiqylylpwpDhgvpllellleflefidellalspg......gpvlVHCsaGvgRtgtlvaay

IIVsriteeHRVGFKETMSAIKMQRFGCFRTVG
..       ... . |... ....|.|.. . .
lml......lglsleeavalvrekRpgavqnps

0051429 (Phosphotyrosine protein) phosphatases II 116-357 1.7e-09 33.2 In-house 4-224 (272) alignment
Range on Protein: 116-357
Range on HMM: 4-224/272.0
DDFYNASWVDGYSK---KSAYIFAQAPFNDhTEYVFWRMvSERKPSMILVFGDIDEKQKRKAPYDISdrgfeksflhefgaksleecelkakicrkfwpe
.. .||..|.|| .   . ... ...| .  |.  |||.  | . ..|. . . .|... | .. .                                  
sgyiNardvggygrvvkpgrlyrsggplpl.taadfwrl.kelgiktivdLrseeErgrlkcdrywp.................................

kgskkDFPALSIQASDDHSETHM-------------------KTFNLTVT-EKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLqyirsskktgvcIG
     ..  | .   ||. .|.                     .. || .   .. ..  ..|.. | | .  .|..|.. . .               |
.....girylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld............gg

PIMLVCATGVEKCAIYATIDIIVSRITEEHRVG--------FKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|..  |. |.   .... ..... ....|  |           |... .. || | . | . |   .| |...
pvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel

0036282 (Phosphotyrosine protein) phosphatases II 116-342 3.8e-08 28.7 In-house 2-154 (174) alignment
Range on Protein: 116-342
Range on HMM: 2-154/174.0
DDFYNASWVDGYSKKSAYIFAQAPFNdhteyvFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDrgfeksflhefgaksleecelkakicrkfwpekgs
.|..|||..|..   . .|  |.|..      ||.|. | . .... . .  |... | .   ..                                   
sdyinaspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe...................................

kkdfpalsiqasddhsethmktfnltvTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLQYIRSskktgVCIGPIMLVCATGVEKCAIYATIDIIV
                           . .   .  .  ... | | .  .  .|.   ..  ... .        ||.   |  ||   .. . .... 
...........................lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylml

SRITeEHRVGFKETMSAIKMQRFGCFR
 ..  |  |   ... ....|| |.. 
rgll.eslvdaldlvrelRlqrpgmvq

0046846 (Phosphotyrosine protein) phosphatases II 119-345 1e-06 24.2 In-house 15-160 (176) alignment
Range on Protein: 119-345
Range on HMM: 15-160/176.0
YNASWVDGYskksAYIFAQAPFnDHTEYVFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDrgFEKSFLhefgaksleecelkakicrkfwpekgskkd
 ||....|.    ..|  |.|   .| . |..|. | . .... . .  |... | |.. ..  .||  .                              
inanlilgs....rpiatqgpl.prtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..............................

fpalsiqasddhsethmktfnltvtekkqdhqtvLMHFYEWADASKLPEYMLDMRASIKLQYIRSSkktgvciGPIMLVCATGVEKCAIYATIDIIVSri
                                    ... | | .  .   |.    .  .....        ||.   |  |.   . .. .... .  
..................................qylhlpwpDhgvpdlelllellefirealkeg.......gpvlVHCsaGigRtgtlvaayllel..

teEHRVGFKETMSAIKMQRF-GCFRTVG
  |. .   |... ...||. |.. | .
..ekglsveealalvreqRplgavqtpe

0049260 (Phosphotyrosine protein) phosphatases II 124-345 2.1e-07 26.3 In-house 2-137 (152) alignment
Range on Protein: 124-345
Range on HMM: 2-137/152.0
VDGYSKKSAYIFAQAPFNDHTEyVFWRMVSERKPSMILVFGDIDEKQKRKAPYDIsdrgfeksflhefgaksleecelkakicrkfwpekgskkdfpals
.||| .. ..| .|.| . ...  ||||. | . . |..  . .|. | | .. |                                             
idgyampfefiatqgpgpntla.dfwrmlkelgittivmltellelgklkceqyi.............................................

iqasddhsethmktfnltvtekkqdhqtvLMHFYEWADASKLPEYMLDMRASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAIYATIDIIVsriteeHR
                               ... | | .  .  .| . . . .. .. .|.     ||.   |  ||   . .. ....       ..
.............................qylhlpwpDhgvpdlsqlllflllfieklaldkg.....gpvlVHCsaGvgRtgtlvaaylml......lg

VGFKETMSAIKMQRFGCFRTVG
| ..|... ....| | . . |
vsleeavalvrekRpgavpnpg

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 129-316 5.2e-07 24.0 In-house 33-173 (255) alignment
Range on Protein: 129-316
Range on HMM: 33-173/255.0
KKSAYIFaqapfndhTEYVFWRMVSERKPSMILVFGDIDEkqkrkapydisdrgfeksflhefgaksleecELKAKICRKFWPEKGSKKDFPALSIQASD
.|. |..        |   |....   |.. . ...|  |                               | . |  . |  ||  |. .  ... ...
rknlysl........tvdkfyqtivqtktevvvmlcdfae...............................egvekcssyfplekdeklkladvnvtttk

DHSETHMKTFNLTVTEK-KQDHQTVLMHFYEWADASKLPEYMLDMRASIKLqyIRSSKktgvcigPIMLVCATGVEKCAIYATIDIIVS
  ..  ..| ..| |   |.  .||  ..|.   . . ||   ...  .|.  .| ||       .....|.||. ..| .. ....  
ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkv..vrdsk.......svvvhCstGiGrsaafvlaelvyq

subfamily_PTPN6_pd Subfamily PTPN6 197-357 1.5e-14 48.7 In-house 131-296 (306) alignment
Range on Protein: 197-357
Range on HMM: 131-296/306.0
EECELKAKICRKFWPEKGSKKDFPALSIQASDDHSETH--MKTFNLTV-TEKKQDHQTVLMHFYEWADAS--KLPEYMLDMRASIKLQYIRSSKKtgvCI
.| |   . | ..||.. .|...  .|..  ...| ..  .......  ..||. .. . .|| .| |..  | |. .||.   .. .. .....     
kevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea...ea

GPIMLVCATGVEKCAIYATIDIIVSRITEE---HRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|||.  |. |. .   .  |||... |...     .  ....  .. || |  .|   |    ... |.
gpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 197-358 1.9e-10 35.4 In-house 123-288 (325) alignment
Range on Protein: 197-358
Range on HMM: 123-288/325.0
EECELKAKICRKFWPEK-GSKKDFPAL--SIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWAD--ASKLPEYMLDMRASIKLQYIRSSKKtGVCI
.| .|. . | ..||.. |  | | .|  .... .. |.  .. ...  ..| .      ...  | |    | |  .. .   .|    |   .   . 
neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan.tkas

GPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
.||.. |..|| .. .....  .. .. || ||   . .  .. .|    .||  |.   | |... 
tpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 198-357 1.8e-11 38.6 In-house 120-277 (287) alignment
Range on Protein: 198-357
Range on HMM: 120-277/287.0
ECELKAKICRKFWPEKGSkKDFPALSIQASDDH--SETHMKTFNLTVTEKKQDHQTVL-MHFYEWADASKLPEYMLDMRaSIKlQYIRSSKKTGVciGPI
| | . ..| ..|||. |   .   .|.  ...  ..  ....... ..|..|.|.|   .. .| .  |..|.   .   |. . ... .| |   ..|
ekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.vie.emyktqrkrgn..tsi

MLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
.  |. .| . |..  ... . .  .|  .   . .   ..|. |  .||  |   .......
vvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

subfamily_PTPN12_pd Subfamily PTPN12 198-322 1e-08 29.5 In-house 117-238 (290) alignment
Range on Protein: 198-322
Range on HMM: 117-238/290.0
ECELKAKICRKFWPEKGSKKD-FPALSIQASDDHSET-HMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMRASIKLqyIRSSKKtgVCIGPIM
| ||. | |...|||.| ..  | ..... ....  .  .    |.|. .|. ..   .|. .| |    |. . .. . |.|  .|. ..      |..
evelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhg.vPssakslleliel..vrelqe..sedaPlv

LVCATGVEKCAIYATIDIIVSRITEEH
. |. || .  .  .||.. . . .|.
vhCsaGvGrtGtiiaidyvrellkaek

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 198-351 1.3e-06 22.8 In-house 104-252 (290) alignment
Range on Protein: 198-351
Range on HMM: 104-252/290.0
ECELKAK-ICRKFWPEK-GSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYE-WADaSKLPEYMLDMRASIklQYIRsSKKTgvcigPI
... . .  | |. ||. | .  |  |...  .   |  ..| .|.|.  .. . ||  . .. | . .. .|  . . . |  |...  .||     |.
ksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnk.lnvqedtktllsli..qkvk.askt.....pv

MLVCATGVEKCAIYATIDIIVSRIT-EEHRVGFKETMSAIKMQRFGCFRTVGPYSTAC
.. |  |. . |. |.|..    |   .. | ... ..|.. ||  .. .   .. . 
ivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 199-357 2.5e-13 44.6 In-house 126-282 (290) alignment
Range on Protein: 199-357
Range on HMM: 126-282/290.0
CELKAKICRKFWPEKGSKKdFPALSIQASDDHSETHMKTFNLTVTEKK--QDHQTVL-MHFYEWADASKLPEYMLDMrASIKlQYIRSSKKTGvcIGPIM
 | . . |...||....|. .   ||. ..... ... . .| |..|.  ...|.|   ..  | .  |....   .  .|. . ..  .|.|   ..|.
ieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil.lvie.emyktqrkrg..ntsiv

LVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
. |  .| . |.. .... . .   |  .   . .   ..|. |   ||  | . ...... 
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_PTPN23_pd Subfamily PTPN23 199-335 4.7e-12 40.3 In-house 118-257 (288) alignment
Range on Protein: 199-335
Range on HMM: 118-257/288.0
CELKAKICRKFWPE-KGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTV--LMHFYEWAD--ASKLPEYMLDMRASIKLQYIRSSKKTGVcigP
 ||. . . ..||| ||  . |..||.  .. ..  ..   .|... ...|.     .... .|..  . . || .|..   .. .|    .|. .   |
eelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt...P

IMLVCATGVEKCAIYATIDIIVSRITEEHrvGFKETM---SAIKM
... | .||..  ..| .  .|  .....  |  ...   | .. 
lvvhCsaGvgRtgvfalvyaavrelekgn..glldiiqvvsrlre

Y_phosphatase Protein-tyrosine phosphatase 200-355 6.6e-18 60.3 Pfam-A 78-234 (235) alignment
Range on Protein: 200-355
Range on HMM: 78-234/235.0
ELKAKICRKFWP-EKGSKKDFPALSIQAS----DDHSETHMKTFNLTVTEKKQ-DHQTVLMHFYEWADASkLPEYMLDMRasiklQYIRSSKKTG-VCIG
| . . | ..|| |.. .. .  ....      .|..|. .....|. .....  ...  .|. .| | . .||   ..      ..||. .|.   . |
ekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg.vpespksll.....dlirkvekskeaksg

PIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
|.. .| .||.........||.......|. |  ..... .. ||.|.. ..  |   .....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 200-355 6.6e-18 60.3 In-house 78-234 (235) alignment
Range on Protein: 200-355
Range on HMM: 78-234/235.0
ELKAKICRKFWP-EKGSKKDFPALSIQAS----DDHSETHMKTFNLTVTEKKQ-DHQTVLMHFYEWADASkLPEYMLDMRasiklQYIRSSKKTG-VCIG
| . . | ..|| |.. .. .  ....      .|..|. .....|. .....  ...  .|. .| | . .||   ..      ..||. .|.   . |
ekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg.vpespksll.....dlirkvekskeaksg

PIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
|.. .| .||.........||.......|. |  ..... .. ||.|.. ..  |   .....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 200-357 4e-17 57.4 In-house 135-289 (298) alignment
Range on Protein: 200-357
Range on HMM: 135-289/298.0
ELKAKICRKFWPEKG-SKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKlPEY---MLDMRASIKLqYIRSSKKtgvciGPIM
||.   . |.||..|  . .   .|.........  ....... ..... .. . .|| .|.| .  ||.   .||... ..  . . ...      |..
eldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv.penatsvldllrkvra.sqqqagn.....kpvi

LVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
. |. ||..   .  || .. |. .|. |   ... .....| |  .|   |.   |. ...
vqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_PTPRD_pd Subfamily PTPRD 200-343 9.4e-16 52.5 In-house 127-266 (564) alignment
Range on Protein: 200-343
Range on HMM: 127-266/564.0
ELKAKICRKFWPEKGsKKDFPALSIQASDD--HSETHMKTFNLTVTEKKQDHQTVLMHFYEWADAS--KLPEYMLDMRASIKLQYiRsskktgVCIGPIM
| . . | |.||||| .. .  | .. ..    .. ...||.|. ..... ..    || .| |    . .. .||..  ..    .         |||.
EkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e......pdagPiv

LVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRT
  |  ||.   .. .||... ||.||. |   ....|.. ||     |
VhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 200-348 6.2e-13 43.5 In-house 127-274 (297) alignment
Range on Protein: 200-348
Range on HMM: 127-274/297.0
ELKAKICRKFWPEKGSKKdFPALSIQASDD--HSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPeymlDMRASIKLQYIRSSKK--TGVCIGPIM
. . | |...|..||... |  .|.. .     .    .....|  . |. .     .| || | .         .||  |..|   .|   ..  ||..
nerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver....kdsassllklisevrkdfsqnaegPll

LVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYS
. | .|| . ... ||| .|... .|. |   .... .. .|    .|   |.
vhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqyk

subfamily_Ptp69D_pd Subfamily Ptp69D 200-357 7.1e-13 43.3 In-house 127-285 (307) alignment
Range on Protein: 200-357
Range on HMM: 127-285/307.0
ELKAKICRKFWPEKgSKKDFPALSIQASDDHSETH--MKTFNLTVTEKK----QDHQT-VLMHFYEWADaSKLPEYMLDMRASIKlqYIRSSKKTGvcIG
| . | | |.||.   .. .  . ..  . .. ..  ....... ....    .|..  |  |. .| | || ||    .   |.   .|. .|.    .
eknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkD.skvPevargllklie..qvrelykln..rs

PIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
||.. | .||.. .|. ..|... .. .|..|   ||.  .. ||   ..    |.     |...
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy

subfamily_PTPRA_pd Subfamily PTPRA 200-358 2.9e-10 34.5 In-house 137-295 (330) alignment
Range on Protein: 200-358
Range on HMM: 137-295/330.0
ELKAKICRKFWPEKGSKKdFPALSIQASDDHSETH--MKTFNLT----VTEKKQDHQTVLMHFYEWADASkLPEY---MLDMRASIKlqyirssKKTGVC
| | . | ..||..|.   .  . ..  |.    .  .. | ..     |..|.  .   .||  | |   .|     ||.. . .|       |.  . 
erkeekcaqywPdeGlvt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG.vPfepiGmlkllkkvk.......klnqqs

IGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
 |||.. |..|| .   . ..| .. |.  |..|   |... ...||    .|   |    ..|... 
agpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 200-359 8.1e-10 33.2 In-house 109-269 (274) alignment
Range on Protein: 200-359
Range on HMM: 109-269/274.0
ELKAKICRKFWPEKGSK---KDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADAsKLPEY---MLDMRASIklqyIRSSKKTGVCIGP
| . . | ...|.. .    . .  ..|. ..  .. . .  .|.. . .. .. . . . .| |  | |.    .||. . .     .| ...   ..|
eaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdh.ksPddantlldlvlev....eesreeenaklap

IMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAV
... |. |. .  .. .|.| | .. ||. |   .... ....| |  .|   |    ..|.... 
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_PTPRN_pd Subfamily PTPRN 200-344 1.1e-07 25.9 In-house 136-278 (297) alignment
Range on Protein: 200-344
Range on HMM: 136-278/297.0
ELKAKICRKFWPEKGSKKdFPALSIQASDDH--SET-HMKTFNLTVTEKKQDHQTVLMHFYEWADASK--LPEYMLDMRASIKLQYIRSSkktgvCigPI
|   | |...||..||.  . .  ..   .|  ..   ...| |   ....      .||  | . .    .  .|..|  .   |   |     |  ||
eegvkqckrywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrs.....c..pi

MLVCATGVEKCAIYATIDIIVSRITEE-HRVGFKETMSAIKMQRFGCFRTV
.. |  |. .. .|  ||....|..   ...    |.  .. || |  .| 
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktk

subfamily_PTPN1_pd Subfamily PTPN1 201-344 2.6e-08 27.9 In-house 108-257 (290) alignment
Range on Protein: 201-344
Range on HMM: 108-257/290.0
LKAKICRKFWPEKGS--KKDFP--ALSI--QASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADAS--KLPEYMLDMrasikLQYIRSSKKTGVCIG
 .   | ..||.. .  .  .    |..   . ...|.  .....|.  . .. .. . .|.  |.| .  . | ..|..     |. .|.|       |
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkf.....lfkvresGslssdvG

PIMLVCATGVEKCAIYATIDIIVSRITEEHR---VGFKETMSAIKMQRFGCFRTV
| .. |..|. .   .. .| .. .| ...    |  |... ... .|.|  .| 
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 202-360 1.4e-16 55.4 In-house 128-281 (288) alignment
Range on Protein: 202-360
Range on HMM: 128-281/288.0
KAKICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMRASIKlqYIRSSKKTGvcIGPIMLVCATG
  . | ..||... .| .  . ... ... .... . .| .  ||.. ..  ...  |.| .  ||   .. . ..   .  ...     |||. .|. |
gktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhg.vPeskapllellr..qvkvanqad..tgpiivhCsaG

VEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
| .  .. ..| .. .. ||  .   .|.. ...||.    |.  |    |.|.. .  
vGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 202-360 1.4e-14 48.9 In-house 89-244 (250) alignment
Range on Protein: 202-360
Range on HMM: 89-244/250.0
KAKICRKFWP-EKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMldmRASIKLQYIRSSKKTGVCIGPIMLVCAT
. | . ..|| ||  |     .|.  .. ...  .... |. ..|... . . .||  | | .  ||..   .| ..|.    ...  .  .|... |..
sektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkg.vPeva...tavLellkkvqasqqqagnaPvivqCsa

GVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
|| .   . .|| .. |. .|. |   . . ... .| .  ..   |.   |...|. ..
GvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 202-356 2e-14 48.4 In-house 128-278 (318) alignment
Range on Protein: 202-356
Range on HMM: 128-278/318.0
KAKiCRKFWPEKGSKkDFPALSIQASDDH--SETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKlPEYMldmraSIKLQYIRSSKKTG--VCIGPIMLV
||| . ..||.|||.  . .| ......   |.  ...|..| ||...  |    |. .|.| .  ||       .  |. .|...|.      |||.  
kak.vhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv.pesg.....aslldlvrqvskaqqksgagpivvh

CATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
|..|| .  .. ..||.. || .|  |   .|.. .. ||    .|   |    ..|..
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle

subfamily_PTPN9_pd Subfamily PTPN9 202-359 2.9e-14 47.8 In-house 123-291 (297) alignment
Range on Protein: 202-359
Range on HMM: 123-291/297.0
KAKICRKFWP-EKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHF--YEWADA--SKLPEYMLDMRASIKLQYIRSS-----KKTGVCI
.   |...|| |..| ..|  ||..  ....| . |.  |.... |....  ..||    | |    .  . .||..  .. .   ..     ...| . 
grlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

G-PIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAV
| ||.. |..|. .   ..|.|| .||. |.  |   ||.. .. ||    .|   |      .. .|.
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 202-360 1.4e-12 42.4 In-house 127-285 (305) alignment
Range on Protein: 202-360
Range on HMM: 127-285/305.0
KAKICRKFWPEKGSK-KDFPALSIQASDDHSETHMKTFNLTVTE---KKQDHQTVLMHFYEWADASkLPEYMLDMRASIKLQYIRSSKKTGVcigPIMLV
. . ||..|||. .. |.|  .|.. .. .. .   . .|...    .|.... . ... .| |    |..   .   ||    . .|  ||   |.. .
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhG.vpqfatsllslikrvqkdqkkdkgv...pllVh

CATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
|  || .  .. ..|| . |. .|  | . | . ... .| .   |   |    ..| .   .
CsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 202-358 4.6e-11 37.2 In-house 130-279 (315) alignment
Range on Protein: 202-358
Range on HMM: 130-279/315.0
KAKICRKFWPEKgsKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWAdASKLPEYMLDMrasikLQYIRSSKK-TGVCIGPIMLVCAT
. . . |.||.|  |  .  ...   ..  .|..    |.|. ... .. | .|.  |   ...|.| . .     ...||  |.     .|.|.. |  
ekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswp.dmgvpkytipl.....mnlirtvkqhhtnsvgaivvhcsa

GVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
|| .   . |.| .. ..  |. .   . .  .. .| .  ...  |    ..|..  
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 202-347 2.1e-10 35.2 In-house 125-265 (281) alignment
Range on Protein: 202-347
Range on HMM: 125-265/281.0
KakiCRKFWPEKGSKKDFPALSIQASDDHSETH--MKTFNLtVTEKKQDHQTVLMHFYEWADA--SKLPEYMLDMRASIKlQYIRSSKKtgvciGPIMLV
|   | ..||.. |.  .  . ..    .....   ..|.|  .|. .  . . ...  | |    . .. .|. |. .. .. ....|      |... 
k...ChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl.kltekktk.....aplvih

CATGVEKCAIYATIDIIVSRITEE-HRVGFKETMSAIKMQRFGCFRTVGPY
|..|| .   | ..| .|.....| ...  |...  .. .|    .||  |
CsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 202-360 8.7e-10 32.8 In-house 118-279 (287) alignment
Range on Protein: 202-360
Range on HMM: 118-279/287.0
KAKICRKFWPEKGSKKDFPALSIQASDDH---SETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKL-QYIRsSKKTGVCIGPIMLV
  . | |.|||.         |. . |      |  .... |   | .. .    .....| | .  |  .  .|  ..  |.|   .. .  .||... 
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie.lardasevGPlvvh

CATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
. .|. .  |. .. ..|||  .  ||    ..  ....| .  ..|  .   .| |. .  |
ddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt

subfamily_PTPRG_pd Subfamily PTPRG 202-355 9.2e-10 32.3 In-house 129-284 (563) alignment
Range on Protein: 202-355
Range on HMM: 129-284/563.0
KAKICRKFWPEkGSKKDFPALSIQA--SDDHSETHMKTFNLTVTE---KKQ-DHQTVLM--HFYEWADASkLPEYMLdmrasIKLQYIRSSK-KTGVCIG
... |  .||.    ... ||...   .. ..   ..|. .  ..   ||| |.. . .  |. .| | .  ||. |      .|.... |.  .   .|
grrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg.vPehsl.....pvLifvkkssaankaeaG

PIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
||.  | .|| .  .|  .| .. .| .|. |   ...  |..||   . |   |    . |.
PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 202-361 1.3e-08 28.8 In-house 133-286 (290) alignment
Range on Protein: 202-361
Range on HMM: 133-286/290.0
KAKiCRKFWPEK-GSKKDFPALSIQASD-DHSETHMKTFNLTVTEKKQDHQTVLMHFY--EWADASklpeymLDMRASIKLQYIRSSKKtgvCIGPIMLV
||| | ...||| |    | ....  |  |. .....   |.| .|.. .. .| |.    | | |      . . .   |. .|. .|     ||... 
kak.ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks......valstlallrtlrilrk...asGpvvvh

CATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVTT
|..|. .   ...|.. .  ... . .   ... |..  | .  .    | .  |.|... .  
csaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 202-343 1.9e-06 22.2 In-house 90-226 (239) alignment
Range on Protein: 202-343
Range on HMM: 90-226/239.0
KAKICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLdmrASIKLQYiRSSKKTGVCIGPIMLVCATG
. | |...||.  ||     .... ..  ..  ..|| ..   . ...     ||  | |   .|.|     | . |.  . .| .     | .. |..|
hkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyat...avlglrr.kitkdslpgarpwvihcsag

VEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRT
| .   .  || .. .  ... |   . . ||. .|    .|
vgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 202-343 1.9e-06 22.2 In-house 89-225 (239) alignment
Range on Protein: 202-343
Range on HMM: 89-225/239.0
KAKICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLdmrASIKLQYiRSSKKTGVCIGPIMLVCATG
. | |...||.  ||     .... ..  ..  ..|| ..   . ...     ||  | |   .|.|     | . |.  . .| .     | .. |..|
hkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyat...avlglrr.kitkdslpgarpwvihcsag

VEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRT
| .   .  || .. .  ... |   . . ||. .|    .|
vgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 203-346 3e-11 37.1 In-house 124-264 (515) alignment
Range on Protein: 203-346
Range on HMM: 124-264/515.0
AKI-CRKFWPE-KGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEymldmrASIKLQYIRSSK-KTGVCIGPIMLVCA
 || | |.||.  |    |  ....    .. | .   .|||.  .. .     || || |    ..      .|  |..|.  | ..|    |... |.
dkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh......tssllklikevkadhgqythpliihcs

TGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGP
.|| .  .. .|| .|... . . |   ...  |. .|    .|   
aGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 203-358 5.7e-11 36.9 In-house 103-264 (270) alignment
Range on Protein: 203-358
Range on HMM: 103-264/270.0
AKICRKFWPEKGSK-KD--FPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLQYIRSSKKTGVC---IGPIML
 | | ..||..  .  .  .  ... |. .. |.   . .|...|| . .. |  ....| | .  .|    ....  |. .|  ...       .|.. 
rkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

VCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
 |. ||..  .  ..||.|  . |...|   . ..... .|  . ...  |  . . ....|
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_CG7180_pd Subfamily CG7180 203-356 4.6e-10 33.6 In-house 123-288 (296) alignment
Range on Protein: 203-356
Range on HMM: 123-288/296.0
AKICRKFWPEKGsKKDFPALSIQASDDHSETHMKTFNLTVTEK-----------KQDHQTV-LMHFYEWADASKLPEY---MLDMRASIKLQYIRSskKT
|| . ..||.|. |...  . ..    .. ...|. .. .| |           | .  .| |... ||    |.|     ....|  ..|   .   . 
akmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv..de

GVCIGPIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
    ||.. |.  |. .  .| .||. .  . .|..| . | .  .. .| .   .|  |    ..| .
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_PTPRK_pd Subfamily PTPRK 203-347 4.6e-09 30.5 In-house 125-266 (314) alignment
Range on Protein: 203-347
Range on HMM: 125-266/314.0
AKICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTV--LMHFYEWADAsKLPEYMLDMRASIKlqYIRSSKKTgvCIGPIMLVCAT
.  | |.|||.... .   . .  .. ..|  ...|... ....|. . .   ..|  |.|  . | .   . . ..   . .|..     |.|.. | .
rvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvr..rvkksqee..eaGrivvhCsa

GVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
|  .  .. .|||..  | .|. |   ... ... ..     |   |
GaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 203-359 1.1e-08 29.4 In-house 114-267 (283) alignment
Range on Protein: 203-359
Range on HMM: 114-267/283.0
AKICRKFWPEKGSKkDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLdMRASIKLQYIRSSKkTGVCIGPIMLVCATGV
 . | ..||..||. |.  . .   .. ..  .   .|..  .   ..|.|.  |   |  .  |    . . .|.  ..| . |    |||.. |.||.
rikCsqyWPkrGse.dyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqai.inslvkfnkvislq.teskkgPivvhCstgi

EKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAV
 . |.. ..   |  .  |  |   ...  .. || .  .| . |    |. .. |.
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 203-341 7.5e-07 23.6 In-house 84-222 (237) alignment
Range on Protein: 203-341
Range on HMM: 84-222/237.0
AKICRKFWPEKGSKKDFPAL--SIQASDDHSETHMKTFNLTVTEKKQDHQTVL-MHFYEWADAsKLPEYMLDMRAsIKLQYIRSSKKTGvCIGPIMLVCA
 . | |.||.    . .  |  |..  .. |.  .... |..  .... . .   .|  | |   .|..   .   .. . |  |..     || .. |.
elkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdr.gvpqqtaallr.frkniinrsphvs.esgpwiihcs

TGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCF
.|| . .|.  || .. .  |.. |   . . .|. .|    
agvgrtgiflvidamlrqakekkvvdiynyvysieedrpyii

subfamily_PTPN3_pd Subfamily PTPN3 204-357 1.2e-14 48.9 In-house 124-274 (280) alignment
Range on Protein: 204-357
Range on HMM: 124-274/280.0
KICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKK--QDHQTVLMHFYEWADAsKLPEYMLDMRASIklQYIRSSKKtgVCIGPIMLVCATG
. | ..|||.. . ..  .|.. . ..... . . .|....|.  .... . . . .|.|  ..|.   |.   .  . .|. ..  .   |... |..|
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdh.gvPddsadflefv..ervrklrs..gkeePvvvhCsaG

VEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
...  .. .... .. | ... |   . .. .. ||    .|.. |   || ..| 
igrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPRB_pd Subfamily PTPRB 204-356 1.1e-13 45.9 In-house 134-283 (293) alignment
Range on Protein: 204-356
Range on HMM: 134-283/293.0
KICRKFWPEKGSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMRASIklQYIRSSKKTGVCIGPIMLVCATGVE
. | ..||.. .   .  ....   ... ..  . .|.....|. ...  .||  |.|    ||    . . .  . .|.....    .||.  |. || 
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhg.vPektktlldfv..rtvreaiektaskrPivvhCsaGvG

KCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
.  .. ..| ....|.||  |    ........|.    |.  |    . ...
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 204-347 6.2e-12 40.0 In-house 126-266 (315) alignment
Range on Protein: 204-347
Range on HMM: 126-266/315.0
K-ICRKFWPE-KGSKKDFPALSIQASDDHSETHMKTFNLtVTEK-KQDHQTVLMHFYEWADASklpeymLDMRASIKLQYIRSSKK-TGVCIGPIMLVCA
|  ||..||. |.   .| .....  . .. | . . .| || | .. ..    .| || |         | ..|  |..|.  |   |    .... |.
kikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkG......vdkqtssllklikevkadngkkefsllvhcs

TGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
.|| .  .  .|| .|..| ... |   ...  .. .|    .|   |
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeey

subfamily_PTPN14_pd Subfamily PTPN14 204-357 3.1e-08 28.0 In-house 133-295 (300) alignment
Range on Protein: 204-357
Range on HMM: 133-295/300.0
KICRKFWPEKGSKK---DFPALSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWADASkLPEY---M---LDMRASIKLQYIRSSKKtGVCIG
. . |..|...|||   .|    ...   .. . . |  |..     |.. . . . . .|.|   .||    .   |..  |.. .  ....       
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhg.vPeDvkgflsyLeevqsvrrktnseves.keskP

PIMLVCATGVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|... |. || .  .  . |.... .  ....  |.... .. ||    .|.. |    ..|.|.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 205-358 1.5e-10 35.7 In-house 132-283 (319) alignment
Range on Protein: 205-358
Range on HMM: 132-283/319.0
ICRKFWPEKGsKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDH---QTVLMHFYEWADAsKLPEYMLDMRASIKlqYIRSSKKTgVCIGPIMLVCATG
 ..|.|||.   ...  | ..  ...   ..   .|.. .|...    . .  .. ||.|  . ||. . . . .|   || |..     |||.  |. |
klkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdh.dvPekatslldllk..rirksrek.tqsgPivvhCsaG

VEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
| .   . ..|... |. ||  .   .|.| ...||    ..   |.   | |....
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav

subfamily_PTPN13_pd Subfamily PTPN13 205-347 4.2e-10 34.4 In-house 118-258 (273) alignment
Range on Protein: 205-347
Range on HMM: 118-258/273.0
ICRKFWPEKGSKKDFPA--LSIQA--SDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMrasikLQYIRSSKKTGVCIGPIMLVCAT
 |...|||. .||      | ..     ....  ....... .| .. .. . ..| .| | .  |   ...     ||...  ..     |||.  |..
kchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhg.vPssaael.....lqfvaevrrlqtdagPivvhcsa

GVEKCAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
|. .  .. |||...  |  .. .  ||..  .. || |  .|   |
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 207-358 4.6e-07 24.1 In-house 112-259 (267) alignment
Range on Protein: 207-358
Range on HMM: 112-259/267.0
RKFWPEK-GSKKDFPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFY-EWADASKLPEYMLDMRAsiklqyIRSSKKTGVCIGPIMLVCATGVEK
|.||| | |  | .  |... | .. |   .   | .  |..  . | ...| .|   ..   |.  . .      | . ..      |... |. || .
rlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfg......ilaknqlengnrPlvvacsdGvGr

CAIYATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
   . .||  . |. .|  .   . .  |. || |   |   |    |.| ..|
sGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 219-366 9.5e-06 19.8 In-house 131-278 (285) alignment
Range on Protein: 219-366
Range on HMM: 131-278/285.0
FPALSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLQYIRSSKKTGVCIGPIMLVCATGVEKCAIYATIDIIVSRI
|    |  .. . |.   |   ..|  . .  .    . .  .    |. .    |   ..  .  ||      || . |..|| . | .  ||    ||
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatiri

TEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVTTGVVHD
 |.  . . . .  ..  || . ..   .     .||.. .  |||  
menpniemldivremramrfqavqshmqflflyvvlmeyfigegvver

PTPc_DSPc_SM00012 253-355 6e-16 53.9 In-house 4-104 (105) alignment
Range on Protein: 253-355
Range on HMM: 4-104/105.0
LMHFYEWADAsKLPEYMldmraSIKLQYIRSSKKTGVCI---GPIMLVCATGVEKCAIYATIDIIVSRITEE-HRVGFKETMSAIKMQRFGCFRTVGPYS
 .|...| |  ..||..     .  |...|. ||    .   .|....| .|| ........||.......| ..| ..........|| |...|   |.
hyhytgwpdh.gvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl

TACEMLM
  ...|.
flyrall