Gene F36H12.10 in Caenorhabditis elegans

Synonym: CELE_F36H12.10, CELE_F36H12.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf10
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP078_AA protein Get Run
CeleP078_AA_84-366 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 76-367 8.2e-73 241.1 In-house 3-306 (307) alignment
Range on Protein: 76-367
Range on HMM: 3-306/307.0
MTPAPPQTHPIVEQWVLRALDVGVDKLREEFRGLAKYTRPD---MTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPM
. . ..  . . ...||. |  .. .|..||. | ..| ..   ..  .. .|      ..||||.|... | . |||  ...    ..||.|.|| .|.
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpen......kdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpl

I-------PEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqGEKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTY--S
.         ..||..||||..|...||.|. ...|. ||||...||.|. |||||||   ||.|| .   .|...| ..    ....... |..|.   
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseeh....ldgytvrtlevtdldg

GGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPC--PPMPELVKALRDQRAFSIQND
 |..  |.|...|.||| ||||   . |... ..|       .. |..||||||.|||||..|. ..|. . ... .  ....| || ||.||  ..|| 
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

VQYLFIHRVMLNYFLE
 || |.....| ..|.
eqyrflyeallelllk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 77-381 1.3e-214 705.3 In-house 1-305 (305) alignment
Range on Protein: 77-381
Range on HMM: 1-305/305.0
TPAPPQTHPIVEQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMIPEKRFIC
|||||||||||||.||||||||||||||||||||||||||||||.||||||.||||||||||||||||.||||||.|||..|||||||||||||||||||
tpappqthpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrfic

AQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPD
||||||||||||||||||||||||||||||||.|||||||||||||||||.||||.||||||||||||||.|||||.|||||||.|.|||||||||||||
aqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpd

RGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAAL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaal

LTAEN
|||||
ltaen

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 79-365 1.1e-53 177.2 In-house 2-279 (288) alignment
Range on Protein: 79-365
Range on HMM: 2-279/288.0
APPQTHPIveQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaiTKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCpMIPEKRFI
.|....|.  ..| ..   . . . ||.. ||.  . . ...  .|.       .||||...   |  .|||..    .  .|| |.|.      .|..|
epihispv..akvakksarnrtgfseeynsLaalektksvtagrlavna.....kknRyrnilpyDekrvklkkleeeagaDYinasyidg.ekkkkkyi

CAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKltlKSGCVVENVSGSKPMERdpEIQITMLNLtySGGQTMSVRHLQWTEWP
..|||| .|...|| .| .||.. |||| . || || || .|||.|. .|   . | |   . .|| .|    .. ..|      .. . . ..|.. ||
atqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk...nyGsvtvtlveskeled..fvlrkllle..kkkteleitqyqylaWp

DRGVPPCKLTSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| |||  |   ||||. .  .      ||.||||||.||||| .|.. ..... |..    . . |. || |||. .|.  || ||..|.|.  
dhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiD.vagtvaklRkqRallvqtlkqYefiyevllsli

0039614 (Phosphotyrosine protein) phosphatases II 81-369 2.1e-73 242.7 In-house 13-293 (297) alignment
Range on Protein: 81-369
Range on HMM: 13-293/297.0
PQTHPIVEQWVLRALDVGVDKLREEFRGLAKYTRPdMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPMIPEKRFIC
| .  ......|.    .  .|..||  | ... . ..  .. .|..      ||||.|... | | |||  .      ..||.|.|| .. .  ..||.
piplsvldlllllekansktllllefeellslkpd.ysiallpenkd......knrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

AQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGekltLKSGCVVENVSGSKpmerDPEIQITMLNLTYsGGQTMSVRHLQWTEWPD
.||||..|.. ||.|| ...|. ||||.|.||.|. |||||||  .|       . .|....  .    .. . .. |..|. .|..  |.|.|.| |||
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkveh....ldgytvrtlevtn.ngesrtvthfqytgwpd

RGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
 ||||.  . ||.| ..|       .. |..||||||.|||||..|. ..|| . | . .. ..| || || ||  ..|.. || |.....| ... |.
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql.ekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 86-393 6.9e-109 358.6 In-house 2-306 (307) alignment
Range on Protein: 86-393
Range on HMM: 2-306/307.0
IVEQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPS-PCNYIHANYVGCPMIPeKRFICAQGPLDQT
.|. || |.|| ||..|..||| |||.|   .|   |.||.       |||||||.||| . . .  .    .||||||.|  . | |.||||||||..|
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantd......knryqdvkcqdkgrivvkfdglasdyihanylgiaikp.kkficaqgplent

IDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC---VVENVsGSKPMERDP-EIQITMLNLTYSGgQTMSVRHLQWTEWPDRGVP
. .|| |.||.||| ..||||..|..|.|| ||||. .|.||.  .      |.|. |.| .  |   |..| |.. ... .. ...||||..|||||||
qysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanl.gakklapdedlinvttlkvdwaq.ksrtiqhlqwenwpdrgvp

PCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAAL-LTA
. .||...||.|.|. . |.|||||||.||.|||||| .. .|. . . |  | .||. ||.|| ..||...|||..|||.|.||||.||| |. | || 
qinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltk

ENVAKYDKFIKDYN
.   || |.. |||
nyeekyakwlddyn

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 86-370 5.2e-58 191.3 In-house 5-277 (288) alignment
Range on Protein: 86-370
Range on HMM: 5-277/288.0
IVEQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNaNqsPdiaiTKNRYQDVPCQDLSAVKLDqPSPCNYIHANYVGCPMIpEKRFICAQGPLDQTI
..  |. . |...|. |  |.|   . .  |. ..  . |  |    |..||...|. |.. |||.   |  ||.|| | .    ..|.|||| ||. ||
vinawirlvlqiaveglkkeyrdspneasidiidsfia.n..p....trdryenlprcditrvkls.ddpdfyiaanvvssaky.krrlicaqaPlngti

DEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGskpMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLT
.|.| |.... || |||||. .| || | |.|.|  .|||  ..  | |  ..     . |  .....|. .  | ... |..| . ||.| |||   |.
eelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenyls

SLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK-YK
 | ||  ..  . |||||.|||.|||||.. |  .|| .  .     ...|.. ||..|  .||   |||..||..|...| | ||
plrllevlkslqkPivvhssaGvGrtgtlililialeslrldd.flgirsllaklreerfkaiqtemqylyvhrcvleelllkkyk

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 88-368 1.7e-78 258.4 In-house 10-290 (305) alignment
Range on Protein: 88-368
Range on HMM: 10-290/305.0
EQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaiTKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDE
 ..| |.|. |   ||.|| .. ..   .  . . .|...      ||||.|| | |   |||. | | .|||||||  |  | |||||.| ||..|  .
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqea.....gknrykdvgcldnnrvklegpwpheyihanyvstptnp.krfictqaplektcad

FWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC----VVENVSGSKPMERDPE--IQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPP
||.| .|.|||.| |||. .| |  ||..|... ....|... .     |  . |..  ...| .  .. |.| .  .|...  | |  | .|||||||.
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa

CKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
  |. ||||   | || ||||||||||||||..| .||||... . .       ... .|.||  ||| | ||||.|.|.||||..|
adlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 88-380 4.2e-49 161.8 In-house 15-305 (310) alignment
Range on Protein: 88-380
Range on HMM: 15-305/310.0
EQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANqspdiaITKNRYQDVPCQDLSAVKL--DQPSPCNYIHANYVGCPMIpEKRFICAQGPLDQTI
|.... .  .|.. |  ..| |     . .|   .. .      . |||| || |.| | |||  |.    .|||||||    .  . |||.||||..||
enfiiateklgieglvkqyrkldakqdssltyeaykky......mhknrysdvvcldtsrvklkidksryedyihanyvktnyl.rstficsqgplqhti

DEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqGekLTLKSGCV-VENVSGSKPMERDPEIQITMLNLT------YSGGQTMSVRHLQWTEWPDRG
 .|| |..|.. | |..|||..| |. ||  |||.  |  .|   ||. | |.| |       .. .|..          .  . . |  ..| .|||||
idfwrmifqeraesilllckvgeegrpkcvgywpsl.g..vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrg

VPP--CKLTSLELLSAIRgsKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAAL
||   |.     ||. .|  . | |||||||..|....||... ..|. . .    . |..  |. .||  ||...|||.|.||.. .   . .    .|
vpdekchtvpqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkv.daeevktellksraiciqtelqyliidrvriifargetevaekil

LTAE
| |.
llad

0040438 (Phosphotyrosine protein) phosphatases II 89-373 6.1e-78 257.6 In-house 7-284 (317) alignment
Range on Protein: 89-373
Range on HMM: 7-284/317.0
QWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKrFICAQGPLDQTI
...|. |  .. .|.|||. | ... ....  .. .|..      |||| |... | | |||  ...   ..||.|.|| .| .. | ||..||||..|.
lalldllksdftalleefedllslkldtysvaelpenkd......knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntv

DEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTLkSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKL
. ||.|| ...|. ||||....|.|. |||||||   ||.||   . .|...|  .    ...|... | ...  ....  |.|...| ||| ||||   
edFwrmvweqgvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

TSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKY
. |..|.|.| .    . |..||||||.|||||..|....|| . ... .. ..| || || ||. ..|.  || |.....|.|.. |.. ..
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep

0043336 (Phosphotyrosine protein) phosphatases II 92-365 7.9e-69 227.5 In-house 12-277 (278) alignment
Range on Protein: 92-365
Range on HMM: 12-277/278.0
LRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEF
|. |  .  .|..||  | ... ....  .. .|..      |||| |... | | |||.  .   ...||.|.|| .. .|.| ||..||||..|.. |
lelllnlktllllefeellsfkldtysiallpenkd......knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedF

WWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPaaqGEKLTLkSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSL
|.|| ...|. ||||.. ||.|. |||||||   |. ||   . .|....  .    .. . .. |..|.   |..  |.|.... ||| |||.   . |
wrmvwelgvttivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

ELLSAIRG----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
..| |.|     |. |..||||||.|||||..|....|| .  .. .....| || || ||. ..|.. || |.....| |.
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPRA_pd Subfamily PTPRA 92-368 7.6e-45 148.2 In-house 25-298 (330) alignment
Range on Protein: 92-368
Range on HMM: 25-298/330.0
LRALDvGVDKLREEFRGLAKYTrpdmTQVMFNANQSpDIAITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEF
 |. |    ..||||  |   .     |  ... .  .    |||. ..   | | | | . .     .|| | ..       ..|| ||||...|...|
irsad.dnklfreefnalPagp....iqatlelask.eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk.ekdkfiaaqGPkeetvedf

WWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaQGEKLTLKSGCVVENVSGSKPM-ERDPEIQitMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSL
| |. . |   |||| .  |  . |||||||  .|     .    ||..  .. .  |.  .|   |. .    ..  || . .| ||| |||      |
wrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGml

ELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
.|| ...  .     |||||||||.||||| .... .||..  ..    . | || || ||.  .| | || ||..|.|.|.|  
kllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 93-365 5e-63 207.4 In-house 20-283 (290) alignment
Range on Protein: 93-365
Range on HMM: 20-283/290.0
RALDVGVDKLREEFR-GLAKY-TRPDMTQVMFNANQSpdiaITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPmipEKRFICAQGPLDQTIDEFWW
 . . .||.|  |.   |  |     . . .|..|      ..||||.||.|.| . | |..  . .|.|||||      .  || .||.| .|. ..| 
dvvkknvdelakeyleklkpylpvqylerkifdknte....fkknrykdvvcndktrvilkdGydGdyvhanyvkGl...kamfiltqGalkdtvidiwr

MVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVenvsGSKPMERDPEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLEL
||.|.||  |||||. .| || ||.||.|  .|| ||. .  |.     |.  ..| .|.  .| .     |.   ..||.   |||. |.  .|. | .
mvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvl....cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

LSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| ..|    |.|||||||||||||.||||  |. . . |   .. .||.|||. |. |.| |.||| . ...|.. 
lrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldll.dlvralrnsrlnsvqvdiqylalveilldlG

0051299 (Phosphotyrosine protein) phosphatases II 96-365 1.5e-72 239.8 In-house 19-286 (288) alignment
Range on Protein: 96-365
Range on HMM: 19-286/288.0
DVGVDKLREEFRGLAKYTRPdmtqvMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMV
  |. .|.|||. | ... .     .     .    ..||||.|... | | |||  ...   ..||.|.|. .. .. | ||..||||..|...||.||
angltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmv

IQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTY-----SGGQTMSVRHLQWTEWPDRGVPPCKLTSL
 ...|. ||||.|.||.|. |||||||   |..||..   .|...|  .    .... .. | .|.      .|..  |.|...| ||| |||.     |
weqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseev....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

ELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
..| ..| .    . |.|||||||.|||||..|....|| . ..  .. ..|.|| || || ...|.  ||.|.....| |.
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 97-364 8.5e-50 164.6 In-house 20-282 (319) alignment
Range on Protein: 97-364
Range on HMM: 20-282/319.0
VGVDKLREEFRGLAKYTRPdmtqvMFNANQSPdIAITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVI
 |  .|..||. | . .        |.  . . .  .|||||..   | . |.|    .    .|| |...      ...|| .|.||..||..|| || 
tgetllekefkllkeavnd.....tfdsaske.enkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvW

QNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKltlkSGCVVENVSGSKpMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI
....  .|||.| || .|.|. .||| .. |.     | .. ..   .    | .|.  .||   |  .| .| | |.||||| .||   .. |.||  |
eeessivvmltklveklkvklkkywpeenfee....yGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri

RGSK-----VPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
| |.      |||||||||.||||| .... .||.. |.     . . |. || || . .|.  || ||. ..|..
rksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlRtqRnimvqrpeqYkfiyeallea

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 97-369 2.4e-48 159.9 In-house 17-284 (318) alignment
Range on Protein: 97-369
Range on HMM: 17-284/318.0
VGVDKLREEFRGLAkytRPDMTQVMFNAnqSPDIAITKNRYQDVPCQDLSAVKLDQP---SPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVI
 |  .| ||.  |.   | . |   ...    ..  .||||...   | . |||..       .|| |||.   .  .| .| ||.|| .||..|| || 
sGelllseeyerls...rseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvW

QNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLtlksGCVVENVSGSkpMERDPeIQITMLNLTYSGG-QTMSVRHLQWTEWPDRGVPPCKLTSLELLSA
. .   |||| ...| || |...|||  . ...    | .| ... .  .| .    .  ...| ..  ..  ||  ..|.|||.|||    . |.|.  
eqnsavivmltqeeergkakvhryWPskgsrsy....gklvvelkee..velsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq

IRGS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
..       . |||||||||.||||. .|.. .||.|....    . . || ||.||   .| . || ||. |.|..     
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD.vfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 97-366 1.8e-47 156.3 In-house 8-270 (281) alignment
Range on Protein: 97-366
Range on HMM: 8-270/281.0
VGVDKLREEFRGLAKYTRPDMTQVmFNAnqsPdIAITKNRYQDVPCQDLSAVKLDQ--P--SPCNYIHANYVGCPMIpEKRFICAQGPLDQTIDEFWWMV
. .| ...||  |      |.  | ||    | .   |||| ..|| |.| |.|    |     .||||||.  |.. .. .| .|||  .|  .|| |.
mtlddfkqefsnlpgdppsdlctv.fnq...p.vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmi

IQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGskpmeRDPEIQITMLNLTYSGgQTMSVRHLQWTEWPDRGVPPCKLTSLELLSA
 |..   |||||. .|  . |||.|.|      | .    |  . |       .  .  | |||.| | .|  . |  | ||||  ||      |..|  
wqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedst.....vnkslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrk

IRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRD-QRAFSIQNDVQYLFIHRVMLNYFL
||    | |.|||||.||.||..|.|  |. |      | . ..|  ||   || |.|   ||..| .|.|.. .
irarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 98-366 5.8e-40 132.5 In-house 32-292 (319) alignment
Range on Protein: 98-366
Range on HMM: 32-292/319.0
GVDKLREEFRGLAKYTRPDMTQVMFNANQSPDiaitKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEkRFICAQGPLDQTIDEFWWMVIQ
 . ||. ||| ..| . .  .|   | .|  |    |||. ..   | . |||..       .|| | .|     .. ..| |||||| |...|| |. .
dltklevefrracklgvnladqtfanldqnkd....knriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiwe

NKVEQIVMLCktvemgKLKCAQYWPAAQGEKLTlKSGCVVENVSGSKPmerdpeIQITMLNLTYSGGQ--TMSVRHLQWTEWPDRGVPPCKLTSLELLSA
 ..  ||.|       | ||.||||    .|   .    |. |  ..         .  ..|.  | .    ...   .  ||| |||      . |.  
yncstivllt......kdkcsqywplkivikee.rfkvkvdsveetae......yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

------IRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
          . .||||||||.||||. .... .|... |.|    . ..|. ||.||   .|. ||| ||.  .|. .|
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 99-365 1.8e-51 170.2 In-house 26-290 (298) alignment
Range on Protein: 99-365
Range on HMM: 26-290/298.0
VDKLREEFRGLAKYTRpDMTQVMFNANQSPDiAITKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQN
. .. .||. | . .  .. .   .. ..|.    ||||.|.   | | | | .      ..|| | ..      .. || .|.|| .|. .|| ||...
ltgyalefqrlnsvss.eieeeekevarkpe.nkkkNRyadiialdssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedFWrmvtee

KVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLtlkSGCVVenvsGSKPMERDPEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR
... |||| ...|..|.|. .|||  . |.        |      .  |.  .. .. |... ..  .. .||.|..|.|||.|||  . . |.||. .|
digtiVmltnleeldktkyhkywPdegkety...geitv....sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

GS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 |     ..|..|.||||.||.|| .||. .||.. ...    . . ||.|| .|. ..|   || ||. ..|...
asqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_ptpA1_pd Subfamily ptpA1 99-324 1.3e-30 101.5 In-house 20-256 (418) alignment
Range on Protein: 99-324
Range on HMM: 20-256/418.0
VDKLREEFRGLAKYTRPDMTQvmfnaNQSPDIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMiPeKRFICAQGPLDQTIDEFWWMVIQN
. |..|||| | .   |  |      .       .|||| ..   . . |.|   ..    .|| |||.     | |.|||.|||| .|| .|| || .|
ihkikeefrlleesvgpsets.....egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.p.kqfictqgplpntiadfwrmvwen

KVEQIVMLCKTVEMGKLKCAQYWPAAQ-GEKLTLKSGCvvENVSGSKPM-----ERDPEIQITMLN--LTYSgGQTMSVRHLQWTEWPDRGVPPCKLTSL
..  |||| .  |  ..|| .|||    ||....      ..| |.  .      .||| .|   |  ||.  |.|  . . |.  |||. .|       
rcriivmlsresencrikcdrywpeqiggeqfsiygng..nevfgtysvelveviqdpereiitrnirltfe.getrditqyqyegwpdhnipdhtqpfr

ELLSAIRG----------SKVPIVVHCSAGIGRTGTIVAIEYILEKI
.|| .|             .|||.||||||.|||||...   ...|.
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl

subfamily_PTPN12_pd Subfamily PTPN12 100-370 1e-57 190.3 In-house 8-282 (290) alignment
Range on Protein: 100-370
Range on HMM: 8-282/290.0
DKLREEFRGLAKYTRPDMTQVMFNANQ-SPDIAITKNRYQDVPCQDLSAVKLDQPSPCN---YIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQN
... .||  | | ..   .. ...... . .  ..||||.|.   | | |.| . .  .   || ||..  .   ....| ||||| .|.|.|| |... 
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiwek

KVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVveNVSGSKPMERDpeIQITMLNLTYSgGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG
.|| .||.|. ||.|| ||..|||  ..|.|.  . .|  ...  | .. |  . | .|... . ... .|. ...|.|||.|||  . . |||....| 
nveivvmaCrevelgkkkCerYWpeegeeelefgefev..tleeekavddd..flirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvre

----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKP--CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYK
    ...|.|||||||.||||||.||.|. | . ..|   .  . .||  || |||  .|   || .... ..... .. .
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 100-366 1.7e-40 133.7 In-house 20-284 (290) alignment
Range on Protein: 100-366
Range on HMM: 20-284/290.0
DKLREEFRGLAKYTRPDMTQVMFNANqspdiAITKNRYQDVPCQDLSAVKLDQPS-----PCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQ
.. |..|  | .  ..  ..| .  .       ..||....  .|   . | . |     . .||.| |.      .|..| .|||. .|. .|| .. |
egfrnqfkmldsgesehtvtvgltss.....nkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsntlvdFWkliwq

NKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSkpmeRDPEIQITMLNLTYSgGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI-
.||  ||||.. .|.|| || ||||... ...   |  .... . .    .  |... . | . . |.. || ..| | |.. |  ... |.| ... . 
ekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln....eyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemy

----RGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
    .  . .||||||...||... .|..  ..|   .     . ...| .| |.  |.|  .|| .|....|.|. 
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi.dvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_PTPRN_pd Subfamily PTPRN 100-359 3.7e-30 99.7 In-house 29-286 (297) alignment
Range on Protein: 100-359
Range on HMM: 29-286/297.0
DKLREEFRGLAKYTRPDMTQVMFNANQspdiAITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNK
|.|..|. .|..|   . |. . .|..    ...|||...|   | | |||.. .     .|| |  .      .  .| .|||| .|. .|| || .. 
drlekewealcayeaepstkevakaek....nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

VEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL-KSGCVVENVSGSKPMERdpeiQITMLNLTYSggQTMSVRHLQWTEWPDRGVPPCKLTSLELL----S
|  ||.|..  | |  .|..|||    |   . .   | | .     . |     . . ||  |  .| .|  . .  ||..|||.   . ||.      
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvr....sfylknlqts..etrtvtqfhflswpeegvPasaksllefrrkvnk

AIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHR
. ||   |||||||.| ||||. ..|. .|....       .   .. |||||.  ..   |. |.  
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

DSPc_SM00195 101-365 4.6e-76 251.0 In-house 1-262 (263) alignment
Range on Protein: 101-365
Range on HMM: 1-262/263.0
KLREEFRGLAKYTRP-DMTQVMFNANQspdiaiTKNRYQDVPCQDLSAVKLDQP---SPCNYIHANYVGCPmIPEKRFICAQGPLDQTIDEFWWMVIQNK
||.|||. | ..| | ..|.. ...|.      .||||..... | . |||...   .. .||.|||. ..  ..|..|..||||..|...||.||...|
klkeefekleestspketteaekkknk......sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweek

VEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKsGCVVENVSGSKPMerdPEIQITMLNLTYSGG-QTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG
|..||||.. .| || ||..|||  .|.| | .    |..|.  |      ||... |.||. |  .| .|...|...|||.|||  .   ||||.|.. 
vkiivmlteeeengkekcdrywpeesggketfg.kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

S----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
|    ..|||||||||.|||||.|.|..||.|..|.|  . . |.||.||.||. ..|.. |||||....|.|.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 101-365 4.6e-76 251.0 In-house 1-262 (263) alignment
Range on Protein: 101-365
Range on HMM: 1-262/263.0
KLREEFRGLAKYTRP-DMTQVMFNANQspdiaiTKNRYQDVPCQDLSAVKLDQP---SPCNYIHANYVGCPmIPEKRFICAQGPLDQTIDEFWWMVIQNK
||.|||. | ..| | ..|.. ...|.      .||||..... | . |||...   .. .||.|||. ..  ..|..|..||||..|...||.||...|
klkeefekleestspketteaekkknk......sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweek

VEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKsGCVVENVSGSKPMerdPEIQITMLNLTYSGG-QTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG
|..||||.. .| || ||..|||  .|.| | .    |..|.  |      ||... |.||. |  .| .|...|...|||.|||  .   ||||.|.. 
vkiivmlteeeengkekcdrywpeesggketfg.kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

S----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
|    ..|||||||||.|||||.|.|..||.|..|.|  . . |.||.||.||. ..|.. |||||....|.|.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0047943 (Phosphotyrosine protein) phosphatases II 101-365 1.2e-72 239.9 In-house 13-272 (273) alignment
Range on Protein: 101-365
Range on HMM: 13-272/273.0
KLREEFRGLAKYTRPDMTQVMFNANqspdiAITKNRYQDVPCQDLSAVKLdQPSPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQI
.|.|||. | ... .  ..|    .      ..||||.|... | | ||| ......||.|.|| .. .. | ||..||||..|...||.|| ...|. |
llleefelllslkplltysvallpe.....nkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrvi

VMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG----
|||...||.|. |||||||  .||  .      |...|  .    .. . .. | ||. . |..  |.|...|.||| ||||     ||.. ..|     
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
  |. |.|||||||.|||||..|....|. . ..  .. ..|.|| ||.||  ..|.  ||.|.....|.|.
lpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_PTPN23_pd Subfamily PTPN23 101-371 4.1e-48 158.6 In-house 16-285 (288) alignment
Range on Protein: 101-371
Range on HMM: 16-285/288.0
KLREEFRGLAKYTRPDMTQVMFNANQspdIAITKNRYQDVPCQDLSAVKLDqPSPCNYIHANYVG--CPMIPekRFICAQGPLDQTIDEFWWMVIQNKVE
.| ..|. | ..   .  .    . .   .  .|||..|.   | . |||.  |  .|| | .|    |. |   ||..|.||..|. .|| || ..|..
aldkkfkeleqkqdkearkrsiaiak...lyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcP..dfiatqaPlqstlnDFWlmvyeqkss

QIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSgcvvENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG---
 |||| .  |.|| |...|||...||  . .      .|. ..  | .. .. ..   | .  .. ||.|||.|.||. |||    | |..| ...    
viVmllskeelgkpkvdrYwPedkgetvkfgd....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesaye

-----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFlEKYKE
     ||.|.|||||||.||||..  .  ..... ...  . ....|. || || |..|.  |. |   ..|..  ... .
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa.rrvld

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 101-365 1.5e-31 104.3 In-house 16-293 (301) alignment
Range on Protein: 101-365
Range on HMM: 16-293/301.0
KLREEFRGLAKYTrPDMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQI
|. |... | ... .. ..| .. ....     .. . |     |.  .  . .  .|| |.|.   .  .|.|| ||||...|. .|| ...|.|. .|
kfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg.ysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLCKTVEMGKLKCAQYWPAAQGEKLTLK-------SGC-----V-------VENVSGSKPMERDPEIQITMlnltysggQTMSVRHLQWTEWPDRGVPP
||.... |  | || |||| .. |. .         . .     |       ....|. . .||  ... ..        ....|  || |.||. || .
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk........sswdvlqlqvtdWpqdGvvr

CKLTSLELL-----SAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 . | |. .        . .. |.|||||....|.|. ....  ||    .     . ...||.| ..   ..   || .|. |.  |.
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

0046845 (Phosphotyrosine protein) phosphatases II 102-369 7.1e-74 244.0 In-house 2-278 (284) alignment
Range on Protein: 102-369
Range on HMM: 2-278/284.0
LREEFRGLAKYTRPD---MTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPM----IPEKRFICAQGPLDQTIDEFWW
|.|||. | ..| .    ..  .. .|      ..||||.|... | | |||. ...    ..||.|.|| ..     . .|.||..||||..|...||.
leeefeellsltvklllslsvallpen......lsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwr

MVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqGEKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTYS--GGQTMSVRHLQWTEWPDRGVPPCKLTSLE
|| ...|. ||||...||.|. |||||||   ||.||..    |...|  .    .. . ...| ||.   .|... |.|...|.|||.||||     ||
mvweqnvrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlle

LLSAIRGS------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKP--CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
.| ..| .      . |||||||||.|||||..|....|| . ....  .....|.|| ||.|| ...|.  ||.|.....|.|.. |.
flrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPRD_pd Subfamily PTPRD 102-365 5.6e-59 195.2 In-house 25-281 (564) alignment
Range on Protein: 102-365
Range on HMM: 25-281/564.0
LREEFRGLAKYTRPDMTQVMFNANQspdiaiTKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVE
. ||.. . . ..  ...   .||.       ||||...   | | |.|    . . ..|| |...   .  .| .| .|||| .||..|| || .....
feeeykkieegqqftweaankpaNk......aKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnss

QIVMLCKTVEMGKLKCAQYWPAAQgeklTLKSGCVVENVSGSKPMErdpEIQITMLNL-TYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-
 |||| |..|.|| ||..|||. .    | . | .. ... .. ..   ...|. ..| . .  ... ||. ..|.|||.|||    . |.|.. .| . 
tiVmltkleEkgkvkchkYWPekg....tetygeltVtleeeeela...dyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln

---KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
   . |||||||||.||||| ..|...||.| |.|    . . ||||| || . .|.  || |||...|.. 
epdagPivVhCSaGVGRTGtfividamlerikeektv.DiyqyvkalrkqRnamVqteeQYiFiheaileal

subfamily_PTPN6_pd Subfamily PTPN6 102-367 4e-49 162.3 In-house 28-299 (306) alignment
Range on Protein: 102-367
Range on HMM: 28-299/306.0
LREEFRGLAKYTrpdMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPC--NYIHANYVG-CPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVE
. |||  | .     .....   . .     .||||. .   | . |.| .||    .|| |||.       .|..| .|| |..|. .|| || |.. .
feeefeelqqee...akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

QIVMLCKTVEMGKLKCAQYWPAAQGEKLtlKSGCVVENVSGSKpMeRDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS--
 |||. | || || |||.|||... ..        |.||| .. . .| ..   ... . ..... .|.......||| |||  . . |..|. ..    
vivmttkevErgkekCarYWPdeeekee..yGkisvtnvseks.l.adYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCP--PMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
      . |||||||||||||||.. |. .|..| ...      . .||| .|.||   .| . || |..... .|  .
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_PTPRG_pd Subfamily PTPRG 102-381 1.4e-45 150.6 In-house 21-304 (563) alignment
Range on Protein: 102-381
Range on HMM: 21-304/563.0
LREEFRGLAKYTRPDMTQVMFNanQSPDiAITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKV
. |||  | . | ..  .. .   | |.    |||| ..   | | ||| . .      .|| |||.      .| || .|||| .|.| || |. ...|
fseefealqsetiskdldaehs..qkpe.nkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidG.yqkskafiatqgplkdtfddFWrmiWeqnv

EQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLS---AIR
. |||. . || |. || .|||. . |..   .   .|.   . . .|   |. . |. . .  .   ||. ..|.||| |||  .|  |       | .
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

G-SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAALLTA-EN
     |||||||||.||||| .... .|..| ...    . ...| .| || | .|.  ||.|.| ..|.  . | .|  |  . . .|
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelkn

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 103-366 6.1e-37 122.0 In-house 13-278 (287) alignment
Range on Protein: 103-366
Range on HMM: 13-278/287.0
REEFRGLAKYTrpDMTQVMFNANQSpDIAITKNRYQDVPCQDLS--AVKLDQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQI
 .|.  | . .  . . ..| | .    |. |||| ||   | .   .  .     .|| ||||      ...||.||||.  |. .|| .|.....  .
dkevdalkeds..esstatfkaaee.laavkknryadvlPiddtrvllsaegelGsdyinanyvas.ytddeafiaaqgPiaatvrdfwravletrsasv

VMLCKTVEMGKLKCAQYWPAAqgEKLTLKSGCVVENVSGSkpmERDPEIQITMLNLTYSGGQT-MSVRHLQWTEWPDRGVPPC--KLTS--LEL---LSA
... . || ..||| .|||    |.  .  |  |  .. .    ..||  .  | |    ..    |. |.. .|||....|    |    |.    . .
itmtreveearlkcykywPer..evPmrvGGysvvlldyd...ikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

IR-GSKV-PIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
 | .|.| |.|||...||||.|...|.  ....  .      .   |  || .||  .|  ||. ..   .  |. 
ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrv.dvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Ptp69D_pd Subfamily Ptp69D 104-365 2.1e-45 150.2 In-house 26-286 (307) alignment
Range on Protein: 104-365
Range on HMM: 26-286/307.0
EEFRGLAKYTRPDMTQvmfNANQspDIAITKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQI
.|.. | . . .  |.   ....  .    ||||.|.   |   ||| .       .|| |...      .|.||.||.|...||..|| |. . .|. |
keyekLeareidkstk...vsek..kenalknRyedikafDktRvkLkkingkedsdYinasfikg.ykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCKTVEMGKLKCAQYWPAAQGEKLTlksGCVVENVSGSKPME-RDPEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI----R
||| .  |. . |||.|||  .  .       .|. || .|  .    |..... . .     ..  |   ..|.|.|  || .  . |.|.. .    .
vmlsnlteknrkkcakYWpiedevqyg...dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

GSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 .. ||||||||| ||.|..||.. .|... ... .  . | || || || . .|.  || |..| .|.| 
lnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 104-369 2.2e-20 67.5 In-house 26-283 (303) alignment
Range on Protein: 104-369
Range on HMM: 26-283/303.0
EEFRGLAKYTRPDMTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDQPSpcnYIHANYVGcpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVML
.||  .. |  |....  |  |      . |||. || | | | ||| . |   ||||.|.   .  .|. | .| || .|  .|| |.|..||  ...|
nefekvvsylppsvsknqfvkn......mdknrfvdvicldhskvklsdss...yihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlll

CKTVEMGKLKCAQYWPAAQgEKLTLKSGCVveNVSGSKPMERDPEIQITMLNLtySGGQTMSVRHL-QWTEWPDRGVPPC---KL--TSLELLSAIRG--
    |. ||     .|  | . | ..   .   |   | .|     .. .| .  | |.  |  |. .. .||   .|     |.     .| | .|   
ltdseydklggdsvfprnq.dflkfeersi..rvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys

SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
   | |    .| ||.||.  .|     . .....  .   .. .|. |  ..||  |. ... .. .. |.. 
dstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 105-366 1.5e-38 127.9 In-house 3-256 (284) alignment
Range on Protein: 105-366
Range on HMM: 3-256/284.0
EFRGLAKYTRPDMTQVMFNANQSPDiaitKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEkRFICAQGPLDQTIDEFWWMVIQNKVEQIV
||| ..| . .  .|   | .|  |    |||. ..   | . |||..       .|| | ..     .. ..| .||||| |...|| |. . ..  ||
efrracklgvngtdqtfanldqnkd....knrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstiv

MLCktvemgKLKCAQYWPAAQGEKLTlKSGCVVENVSGSKPmerdpeIQITMLNLTYSGGQ--TMSVRHLQWTEWPDRGVPPCKLTSLELLSA------I
.|       | ||.||||    .|   .    |. |. |.         .  ..|.  | .    ..|   .  ||| |||      . |.         
llt......kdkcsqywplkivikee.rfkvkvdsveesee......yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk

RGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
   . .||||||||.||||. .... .|... |.|    . ..|. ||.||   .|. ||| ||.  .|. .|
enhranivvhcsagvgrtgvyivldvlldrmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 108-364 3.3e-39 129.5 In-house 14-265 (283) alignment
Range on Protein: 108-364
Range on HMM: 14-265/283.0
GLAKYTRPDMTQVMFNANQSPdiaiTKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVG--CPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCK
 | . . ||.  ..  |.. .    .|||.|..  .|   |.|.  |. .|| | ..        .|..| ||.|||.|. .|| || ..|.  |||| |
vlkrlsvpdldadiasadenk....rknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

TVEMGKLKCAQYWPAAQGEKLTLKSgCVVENVSGSKPMErdpeIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPcKLTSL---EL-LSAIR-GSKVPI
  |  . ||.||||    |.        ...  .|. .     |.  .|.   |  .|. . | |  .| . |  .  . ||   ..  |  .   | ||
lqedlrikCsqyWPkrGsedyGeft.vtlrkettsnsfi....ikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskkgPi

VVHCSAGIGRTGTIVAIEYILEKIAeNKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
|||||.|||||.. .|.   ....   .    ... || .| ||   .|.  || ..| ..|. 
vvhCstgiGrtavfiaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 108-221 2.8e-08 27.7 In-house 76-181 (244) alignment
Range on Protein: 108-221
Range on HMM: 76-181/244.0
GLAKYTRPDMTqVMFNANQsPDIAiTKNRYQDVPCQDLSAVKLDQPSPCN-YIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKt
|  .  ||| . || .| . |. .  |||       |.. | | . |  | || | .||| .     .| .| || .|  .|| |... .|. .|.|   
gsqniirpdps.vmkdafn.pnns.wknregaglpfdfnrvplskgsmgntyinasfvgc.lgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.

VEMGklkcAQYWPAA
||       .||| .
veee....deywpds

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 109-205 1.6e-06 21.9 In-house 21-118 (347) alignment
Range on Protein: 109-205
Range on HMM: 21-118/347.0
LAKYTRPDMTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDqP---------SPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQ
||.|. ...| | .. .      ..||| .||  .| . | |  |          . .|| | ..      .| .| .| || .|. .|| ||   || |
lanyspskftsveweks......lsknrskdvklidatrvvls.peksknsraddvetyinashikfdn.askeyiltqyplpdtvrdfwkmvsvtkvtq

IVMLCK
.| . .
vvtife

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 110-367 1.4e-39 130.8 In-house 20-272 (285) alignment
Range on Protein: 110-367
Range on HMM: 20-272/285.0
AKYTRPDMTQVMFNANqsPDIaitkNRYQDVPCQDLSAVKLDQpSPCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEM
  |  |. |   ..||  ||.    ||| || | . . | | .    .||||...  |   .  .| .|||| .|. .|| |. |.|.  ..|||  .| 
kgymppnctytayean..pdl....nryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg

GKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI---RGSKVPIVVHCSA
|  ||| |.|   || . .    .       . .       .|..|   .  . . . |.|   |||.  |      .||   .      . ||.|||||
gvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsa

GIGRTGTIVAIEYILEKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
|.||| |.| |.|   .| || |   | ..|. .|  |  ..|. .|.||.. |...||. 
gvgrtatfvgidyatirimen.pniemldivremramrfqavqshmqflflyvvlmeyfig

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 112-363 9.1e-35 114.9 In-house 31-277 (439) alignment
Range on Protein: 112-363
Range on HMM: 31-277/439.0
YTRPDMTQVMFNANQSPDiaITKNRYQDVPCQDLSAVKL-DQPS--PCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVE
 |.|| . .   | |. |   |||||.||   | . | | . |      || |||.      .| .| .||| ..| |.|| .||..|. .||||.. ||
stspdyaciaslaaqeyd..qtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkkettddfwrlviekktvtivmltnlve

MGKlkcaqYWPAAQGEKLtlksGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-----KVPIVVH
  |     |||. .        | ..  |     . .     . ..|   .. .  .| ..... |||. ||      |..| ||  .       |.|||
syk.....ywpsdaevcy....gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvh

CSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
||||.||||||.|..  ||..  ..    .  .|| ||.||   .|. .||.||.  .|.
csagvGrtGtiialdialeqlklenkv.dikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_CG42327_pd Subfamily CG42327 116-292 9.2e-18 59.0 In-house 13-189 (319) alignment
Range on Protein: 116-292
Range on HMM: 13-189/319.0
DMTQVMFNANQSPDIAITKNRYQ-DVPCQDLSAVKLDQPSP--CNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKL
|. |.. .|.. |  .  |.|.   ||  . ..|   ...    .|..|.||  .   .  .|.|| .|...  .|| .| ...   || |..  | |  
dlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGik

KCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDpeIQITMLNLTYSGGQTMSVRHLqWTEWPDRGVPPCKLTSLELLSA
.||.|.|. .. . |   | .   . | .  .|   .  |.|     . ..  . |  | .|.. .||  . . . .|  
vcaeylPtketldntslyGdilvtlkgrevkdry..aistlllkrvdkeesrelthy.wykwleaevPaeeaaliamlle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 117-367 1.7e-33 111.2 In-house 35-290 (325) alignment
Range on Protein: 117-367
Range on HMM: 35-290/325.0
MTQVMFNANQSPDiAITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKvEQIVMLCKTVEMGKLK
   . ...   |.  . |||...|   | | | |    . . ..|| |.|.    .  . |. || || .||...| .|.. .   .|..   .. || .
ddgiakkvamkpe.nkaknrfknvvaldksrvvletkkddpssdyinasylrd.dkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdr

CAQYWPAAQGEKLTLksGCVVENVSGSKPMeRDpEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVP--PCKLTSL-ELLS----AIRG---SKVPIVVH
||.|||   |.  |.  | .  ..   . .  |  ..  .     ..|.|.||. .|.  |.| ||.  |. | |. .|.      ..    .  ||.||
cavywpkemgksktf..Gglevklrtieei.sd.yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvh

CSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
||||.||||. ...  .|.|. |.     . . || || .|   ..   || .|.  . .... 
csaGvGrtGvfislysalakvieesrv.difgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_PTPRB_pd Subfamily PTPRB 121-370 1.8e-57 189.6 In-house 43-290 (293) alignment
Range on Protein: 121-370
Range on HMM: 43-290/293.0
MFNANQSpdIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMIpEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQY
.  |...  .  .||||...   | | |||   .. |  .|| |||.      .. || .|||| .|.|.|| || ..|.. |||| ..|| || || .|
vkaaela..vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeY

WPAAQGEKltlKSGCVVENVSGSKPMErdpEIQITMLNLTYsGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK------VPIVVHCSAGIGRT
||| . .      | .  ..  .. .|   .  |  |...  . ....||....| ||| |||    | |... ..| ..       |||||||||.|||
WPadeepv...lyGdikvtlvaeeele...dwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GTIVAIEYILEKIAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYK
|| .|.. .|..| |.     .  .| .|| .|.. .|.  ||.|||...|... .| .
Gtfialdrllqaieeedyvdif.givaelReeRnllvqtekqYifihqcvldllrkkee

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 125-366 1e-30 101.5 In-house 39-237 (392) alignment
Range on Protein: 125-366
Range on HMM: 39-237/392.0
NQSPDIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGklkcaqywpaa
    .| . ||||...   | . |||   |. .  .|. | |. . .  || .|..|||   ..|.|| || |..|  |.|. |  |             
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.fdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

qgekltlksgcvvenvsgskpmerdpeiqitmlnltySGGQTMSVRHLQWTEWPDRGVPPCKLTSLEL---LSAIRGSKV-PIVVHCSAGIGRTGTIVAI
                                      | .. .|   ..|||||..||    . |..   ..|  |.   |...|||||.|||| ...|
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

EYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
. .. .  . .    . ..|  .| .| . .| . || ||.  .|. .|
dsvvahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 128-365 2e-51 169.6 In-house 15-264 (270) alignment
Range on Protein: 128-365
Range on HMM: 15-264/270.0
PDIAIT--KNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQ
|..| .   |||.|.  .  . |.|   .. |  .|| ||||      .|..|.|.|||. |. .|| |....||. |||. . .| |. ||..|||| .
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

GEKLTLKSGCVVENVSGSkpmERDPEIQITMLNLTySGGQTMSVRHLQWTEWPDRGVPPCKL------TSLELLSAIRGSK------VPIVVHCSAGIGR
.||..|. | .   .. .   |..    .| |.|. . |..  . | ....|||.|||. .         |..| |.| |.       |..||||||.||
kekvkledgkikvlalse...ekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTIVAIEYILEKIAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
|||..|...... . |.| . .. .....|| .|   .|  .|| |.......| 
tGtlialDiavrlLeetkkvdvl.aiieelRkdRmalvqhpeqyeflykavveya

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 128-366 4.8e-43 142.0 In-house 40-277 (515) alignment
Range on Protein: 128-366
Range on HMM: 40-277/515.0
PDIAITKNRYQDVPCQDLSAVKL----DQPSpCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQG
 .|  .||||...   | . |||    |.|   .|. | |.   .  .| .|..|||.. ..|.|| .|.|..|  |.|. |  |  | ||..|||   |
eeinfkknryknilPydsvrvklevindnPh.sdyfnasyips.fdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

EKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTySGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEY
. . . |   || || .     . .  .  |...  | ..  |   ..|||||.|||.   . | |. ... ..     |...|||||.|||| ...|. 
dsvkfGs.ikvelvslea....ctggikrkltvl.kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisids

ILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
.. .... .    . ..|. .|..| . .| . || ||. ..|...|
vvahakttrmv.dvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 128-368 6.4e-36 119.0 In-house 48-287 (297) alignment
Range on Protein: 128-368
Range on HMM: 48-287/297.0
PDIAITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIpekRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGE
  . . |.||...   | | |||         .|. | .|        |.|. | | ..|...|| ||....|  |||| .  |  | |||.||.     
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvt

KltlkSGCVVENVSgsKPMERDPEIQITMlNLTYSG-GQTMSVRHLQWTEWPDRGVPP--CKLTSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVA
.     | |.  ..     ||   |. .. ..| .   ..  |.  |..||||. |.      . |.|.| .| .     . |..|||.||.|||| ...
t....fGdvsvvll..svsereGfikrel.evtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

IEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
|. .. .. ..|    . .||| ||..| . .| . || |.. ..|...| .
idsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 129-366 1.1e-56 187.0 In-house 39-277 (281) alignment
Range on Protein: 129-366
Range on HMM: 39-277/281.0
DIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGek
|  ..||||...   | . ||.   .. . ..|| ||.|   .  ||..| .|||. .....||.||...||..|||. . .| ||||| .|||  .   
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns..

lTLKSGCVVenVSGsKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI-----RGSKVPIVVHCSAGIGRTGTIVAIEYI
 .|| | |.  |.  .  |. ..     ..|. ..|.| .|..|..| ||| |||      ||  ...     . .|.|.|.|||||.||||| .|.. .
.elkygdvt..vks.taeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl

LEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
.........   . ..|. || .| . .|  ||| |.....|... 
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 129-366 1.4e-43 143.9 In-house 42-278 (315) alignment
Range on Protein: 129-366
Range on HMM: 42-278/315.0
DIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEK
.|  .||||...   | . |||   |.    .|| | |.   .  .| .|..||||. ..|.|| ||.|.||  |||. |  |  |.||.||||  ... 
tinfkknryknilPldsarvkleviddsPdsdyinasyiks.vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

LTLKSgCVVENVSgskpMERDPEIQITMLnLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYIL
  . |   || .|    .| | .  .  |  |  . ..  |   |.|||||.||.    . |.|. .....    . ...||||||.|||| ...|. ..
vefGs.ikvells....leadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

EKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
..|....    . ..|| ||..| . .| . .| ||. ..|...|
aqikrtrsv.dvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_egg_pd Subfamily egg 129-367 6.6e-41 135.0 In-house 38-272 (307) alignment
Range on Protein: 129-367
Range on HMM: 38-272/307.0
DIAITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYV-GCPMIPEkrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMgkLKCAQYWPAAQGE
|   .| | . |.|.| | |||. .      ..||||.| | |.. |  ||.|| ||  | |.|| || |..|. ||||  ..|    .|  ||| |. .
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllne..filaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesd

KLTLKSG-CVVENVSGSKpmERDPEIQITMLNLTYSGGQTMSVRHLQWtEWPDRGvppCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEK
 | .  |   .||.   .  . ||  ..| |.|  .  . . . | |. ..   .      . |..|  .|    |.||..  |. ...|.||||  | .
slvtvpGslrienlkvds..kadplfrvtklklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlskpvvvqdilGvskaatlvaieialls

IAENkPC--PPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
.    |    .. . |. || .| .|..  ..|||..|..| .| .
llrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_eak_pd Subfamily eak 129-279 2.9e-09 30.8 In-house 50-194 (332) alignment
Range on Protein: 129-279
Range on HMM: 50-194/332.0
DIAITKNRYQDVPcQDLSAVKLD--QPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
  |. .| .. || .|   |.|   |  .  || |  .  . .  ...| .  . .. .  || ||...|   ||.| . ||..  |  .|.|    |.|
leavnrnvvkivp.ydrylvrltssqlnrlGyinaslaefsevG.rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

tlKSGCVveNVSGSKPMERDpEIQITMLNLTySGGQTMSVRHLQWTEWPDRGV
  | | .  .|   . ..|.  ..  .| |.  | .|  | | .   | .  .
..kfGil..dverkefvkrn.iletrllels.kGnethrvlhykvfGwtettl

subfamily_PTPN9_pd Subfamily PTPN9 130-368 5.7e-55 181.4 In-house 41-293 (297) alignment
Range on Protein: 130-368
Range on HMM: 41-293/297.0
IAITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
  ..||||.|| | | . |.|    . .  .||.||.|      .| || .||||..|...|| || ...|  |||  ..||.|.|||.||||  ...  
anleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessa

TLkSGCVVENVSGSKpMErdpEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-----------------KVPIVVHCSAGI
   .   |.||.  . .|   . ....|...    ... .| | | . ||| |||    . |..|...|                   . ||||||||||
ef.gdlsvsnvevee.ee...dykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
||||| ..... |... |   .  . | || || ||||||| . || | .  .|.| ||.
GrtGtfitldiclsrleevgtv.dvvetvkllrtqrafsiqtpeqyefcylavleyalel

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 130-365 2.4e-49 163.1 In-house 45-283 (305) alignment
Range on Protein: 130-365
Range on HMM: 45-283/305.0
IAITKNRYQDVPCQDLSAVKLDQPSPC---NYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
   .|||....  .| . ..| . .     .|| |.||      .|..| |||||..|...|| .... ||..||||.|.|| || || |||| ...|| 
ankaknrlkeitlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekk

TLKSGCVVenVSGSkpmERDPEIQITMLNLTY--SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR-----GSKVPIVVHCSAGIGRTGTIVAIEY
 . .  |   .. .   .  ..  .  |...   .  .. .| ..| |.||| |||    . |.|.  ..     . .||..||||||.||||. .|.. 
efgefsve..lkse...ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdi

ILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 ||.. . .    . |..|.|| .|   .|.  || |.| .. .. 
alerlkkEevv.dvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_PTPN14_pd Subfamily PTPN14 130-365 3.2e-38 126.4 In-house 48-296 (300) alignment
Range on Protein: 130-365
Range on HMM: 48-296/300.0
IAITKNRYQDVPCQDLSAVKLDQP--SPCNYIHANYVGCPMIPEK-RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
    |||..||   . . |.|     .  .|| |  .  ..  ..  .| |||||..|. .|| || ...|. |||| .. | || |. .|.|  . .| 
enaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkk

TLKSGCVveNVSgSKPMERDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR-------------GSKVPIVVHCSAGIGRTG
|.. |    .|. .|  |  . .  | |.| .   ..  .| |||.|.|||.|||.   . |. |  ..              || |..||||||.||||
tvefgkf..kvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

TIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 ..  . ... .  |.    ... .. || || . .|.  || |...|...|.
vlilsdlliatlehneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikyl

0050432 (Phosphotyrosine protein) phosphatases II 131-369 5.6e-77 254.4 In-house 68-303 (308) alignment
Range on Protein: 131-369
Range on HMM: 68-303/308.0
AITKNRYQDVPCQDLSAVKLdqPSPCNYIHANYVGCPM-IPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLK
 ..|||| |... | | |||  .....||.|.|| ... . ...||..||||..|.. ||.|| ...|. ||||.|.||.|. |||||||  .|.. .  
nkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley

SGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS--KVPIVVHCSAGIGRTGTIVAIEYILEKIAE
 . .|...|  .    .... .. | ||. ..|..  |.|...| ||| ||||     |..| ..| |  . |||||||||.|||||..|....|| . .
gkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlek

NkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
.  .. ..|.|| || ||....|.  ||||..|..| |.. |.
e.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_PTPN3_pd Subfamily PTPN3 131-365 1.1e-54 180.3 In-house 41-275 (280) alignment
Range on Protein: 131-365
Range on HMM: 41-275/280.0
AITKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVGCPMIP---EKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaQGEKLT
 ..||||.|.   |   |||.. .  .|| ||||   .      .|.| .||||..|  .|| || ..|.. ||||  .|| |. || ||||  ....|.
nlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedele

LKsGCVVENVSGskpMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG----SKVPIVVHCSAGIGRTGTIVAIEYILEK
.  .  |.  .     |.   .   ..    .  .  .. .||...||| |||  .   ||... .|     .. |.|||||||||||| ....|  | .
yg.efsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal

IAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| ...|  |. ..|. .|||||  .|.  || |.   .|. .
ieaaepvypl.divrtmrdqramlvqtasqykfvCeailkvy

subfamily_PTPN13_pd Subfamily PTPN13 131-363 3.5e-53 175.6 In-house 37-267 (273) alignment
Range on Protein: 131-363
Range on HMM: 37-267/273.0
AITKNRYQDVPCQDLSAVKLDQPSPcnYIHANYVGCPMIPEK-RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLK
  .||||..|   | . |||.. ..  || |...  |.  .. ..| .|||| .|...|| || . |.| |.|. . .| ||.|| .|||  ...||...
nkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvs

SGCVVENVSGSKpmeRDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR---GSKVPIVVHCSAGIGRTGTIVAIEYILEKIAE
.   ||..   |   .|   . ..       |..  | ||....||| |||   .  |.... .|    .. ||||||||||||.||...|. .|. |. 
nrlevellkvqk...ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglier

NKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
.|.  .. |.|. ||.||   .| . ||.|.....|.
dkef.dvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 131-365 4.1e-49 162.1 In-house 28-268 (274) alignment
Range on Protein: 131-365
Range on HMM: 28-268/274.0
AITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
. |||||...   . | | | . |.     .|| |||.  .   .| .. .|||| .|...|| |. |..|. |||| |  |. . |||.|.| |.. ..
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

TLKSGCVVenVSGSKpMERDPEIQITMLNLTYSGGqTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK-------VPIVVHCSAGIGRTGTIVAIEY
. . | |   .  .| . .  . ... | | |.   . || |  .|.|||. .|    | |.|.  .. |.        |.||||||||||||  .||. 
serygdve..ikvek.iverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 . .. |..    . ..|  || .|   .|.. || .|||..  | 
avrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_PTPN1_pd Subfamily PTPN1 131-358 8.8e-43 141.1 In-house 32-264 (290) alignment
Range on Protein: 131-358
Range on HMM: 32-264/290.0
AITKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVGCPMIpEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQG-EKLTLK
  ..|||.||   | | .||.. .  .|| |. |  . . ....| .|||| .|.| || || ..|   .||| | || ...|||||||  .  ..|.|.
nrnlnryrdvspydhsrikleradn.dyinaslveleea.krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellle

-SGCVVENVSgskpMERDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK------VPIVVHCSAGIGRTGTIVAIEYIL
 .   |. .|     ||  . .. .|.|.  .  .| .. |  .| ||| ||| .  . |..|  .| |        | |.||||||||.||.. .. .|
dtklkvklis....eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtcl

EKIAENKP--CPPMPELVKALRDQRAFSIQNDVQYLFIH
 .| ...   .  . . . .|| .|   ||   |  | .
vliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 131-280 1.2e-35 117.9 In-house 33-180 (297) alignment
Range on Protein: 131-280
Range on HMM: 33-180/297.0
AITKNRYQDVPCQDLSAVKLDQ-PSPCNYIHANYVGCPMIPEK-RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
.. ||||.|.   | . ||| . ..  .|| |.||  |  ... ..|.|||||..|.|.|| .| .. |  |||..|  | |. ||| ||| ...|.|. 
slrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

KSgCVVENVSGSKpMErDPEIQITMLNLTYSgGQTMSVRHLQWTEWPDRGVP
 .  ||| .|     |    ...| |.| |   ..  ||| |.  ||| |||
gd.vvveflssts.de.fdrviltelqliyr.sesrvvrhvqflswpdhGvp

0036941 (Phosphotyrosine protein) phosphatases II 132-368 2.7e-74 245.5 In-house 40-280 (297) alignment
Range on Protein: 132-368
Range on HMM: 40-280/297.0
ITKNRYQDVPCQDLSAVKLdQPSPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLkSG
..|||| |... | . ||| ......||.|.|| .. .. | ||..||||..|...||.|| ...|. ||||.. ||.|. |||||||  .|| ||   .
leknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslty.gd

CVVENVSGSKPmeRDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYILEKI
 .|...| ..    .... .. | .|.  .|..  |.|...| ||| |||..  . |... ..|       |. |..||||||.||.||..|....|. .
ftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

AE--NKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
 .    ......|.|| ||.||....|.  ||.|.....|.... |
edklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0040439 (Phosphotyrosine protein) phosphatases II 132-367 1.7e-65 216.4 In-house 12-248 (249) alignment
Range on Protein: 132-367
Range on HMM: 12-248/249.0
ITKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTL
. ||||.|... | | |||       ...||.|.|. .. |. . ||..||||..|.. ||.|. ..... ||||...||.|. |||||||   |. |. 
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley

kSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYIL
  . .|...|  .     ... ...| ||.   |..  |.|.|.| ||| ||||   . |... |.|       .. |..||||||.|||||..|. ..|
.gdftvtllsvev....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

EKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
| . ..  . ...| || ||.||  ..||. || |.....| ..|.
eqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelllk

0042113 (Phosphotyrosine protein) phosphatases II 132-365 1.7e-64 212.9 In-house 10-243 (245) alignment
Range on Protein: 132-365
Range on HMM: 10-243/245.0
ITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTL
..|||| |... | . |||  ...   ..||.|.||... |..| ||..||||..|.. ||.|. ..... ||||....|.|. |||||||   ||.|| 
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslty

KSgCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG-----SKVPIVVHCSAGIGRTGTIVAIEYILE
.   .|...|  .    .... .. |..|.   ...  |.|.... ||| |||.   . |..|...|      |. |..||||||.|||||..|. ..||
gd.ftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

KIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 . ..  . ...| || ||.||  ..|.. || |.....|...
qleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 132-365 1.4e-61 203.5 In-house 11-242 (243) alignment
Range on Protein: 132-365
Range on HMM: 11-242/243.0
ITKNRYQDVPCQDLSAVKLdqpSPCNYIHANYVGCPmipeKRFICAQGPLDQTIDE----FWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPaaqGEKlt
..||||.|... | | |||   ....||.||.. ..    .|.|. ||||..|...    || |. ..... ||||...||.|..|||||||   ||.  
lsknrysdilpydhsrvkl...egsdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev..

LKSGCVVENVSGSKpmerDPEIQITMLNLTY--SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR------------GSKVPIVVHCSAGIGRTGT
   . .|...| .      ... ...| |..   ...|  |.|.... ||| |||.     |..|...|             |. |..||||||.|||||
tygdftvtllseeh....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

IVAIEYILEKIaenkpCPPMPELVKALRDQRAF-SIQNDVQYLFIHRVMLNYF
..|. ..|...     . .. | || ||.|| . ..|.  || |.....| ..
liaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPRK_pd Subfamily PTPRK 132-363 2.2e-41 136.7 In-house 44-275 (314) alignment
Range on Protein: 132-363
Range on HMM: 44-275/314.0
ITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
 .|||..|.   | | |.|      .  .|| |...     | . || .||||..|. .|| .| ...   |||| . || |..|| .|||        .
reknrsgdilaydrsrvflitidgdpssdyinaalidsykrp.aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdi

KSGCVVENVSgSKPMERdpeiQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKI
|  .|  ..  .. . |      .. .|. .  ..  ||..|.. ||| .||  . . |.|.  .  |    . .|||||||| ||||| .||. .|. |
kvelvetell.aelvvr....ifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi

aENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
 |..    . . ||.||...   ..   || ||. |.|.
.eregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 132-366 2.1e-38 127.0 In-house 50-280 (315) alignment
Range on Protein: 132-366
Range on HMM: 50-280/315.0
ITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqgeKLTL
  |||| ..   | | |.|   .. . ..|. ||..     . .|.|.||||. .....|| .| .... .|||| ..||  | |. .|||     |.. 
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkk.rryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy

KSGCVVenvsgSKPMERDPEIQITMLnLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR----GSKVPIVVHCSAGIGRTGTIVAIEYILEKI
    |       |  |   |. .  |  . .| .   |  |..| ||| |||   .. ..|   ..     |  .||||||||.||||| .... .|...
Gkitvt.....rkseevnteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

AENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
  ..    . .... .|..|   .|   || ||. ..|. |.
eaenai.dvynfitgvrqnrikmvqvaeqyqfiydalletfv

0049772 (Phosphotyrosine protein) phosphatases II 132-368 3.4e-33 111.1 In-house 47-283 (314) alignment
Range on Protein: 132-368
Range on HMM: 47-283/314.0
ITKNRYQDVPCQDlSAVKLDQ--PSPCNYIHANYVGCPmipeKRFICAQGPLDQTIDEF----------WWMVI--QNKVEQIVM---------------
..||||.|... | . |.|.    | ..||.|.|| ..    ..||..||||. |.. |          | ||.  ...|  |||               
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCKTVEMGklkcaQYWPAAQGEKLTlksgcvvenvsgskpmE-------RdpeiqitmlnltysggqTMSVRHLQWTEWPDrGVPPCKLTSLEL
      |..  . |      ...||  | |                 |                         .  . .. .. .|| | .|     .|.
AlgKtpllildgng.....neptaadlellk................eelydpelf.................erlgikylripvpD.gsaplledfdef

LSAIRG--SKVPIVVHCSAGIGRTGTIVAIEYILEKIaenkPCpPMPELVKALRDQRA-----FSIQNDVQYLFIHRVMLNYFLEK
| .|.    . |..|||.||.||||| |.. |.. .      . .. | .. .| .|       .|..  ||.||....|.|.  .
lefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkfl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 132-362 2e-29 97.4 In-house 8-237 (239) alignment
Range on Protein: 132-362
Range on HMM: 8-237/239.0
ITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
 .|||| ..   | | | |.. |     .|| |.|.       | .|..|| .  .  .|| |. |..   ||||   .|  | || |||| .  .   |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

KSGCVVENVSGskpmerDPEIQiTMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKI
.      .|        |  |. |..       .   | . ..| |||.|||    . | |   |         | |.|||||.||||... |. .| . 
rvtlrktevfa......dyiir.tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

AENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVML
 ..|    . . |||.|..| . .|   ||.|||  .|
kkqktv.difnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 132-362 2.3e-29 97.2 In-house 9-238 (239) alignment
Range on Protein: 132-362
Range on HMM: 9-238/239.0
ITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
 .|||| ..   | | | |.. |     .|| |.|.       | .|..|| .  .  .|| |. |..   ||||   .|  | || |||| .  .   |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

KSGCVVENVSGskpmerDPEIQiTMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKI
.      .|        |  |. |..       .   | . ..| |||.|||    . | |   |         | |.|||||.||||... |. .| . 
rvtlrktevfa......dyiir.tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

AENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVML
 ..|    . . |||.|..| . .|   ||.|||  .|
kkqktv.difnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 132-371 8.5e-25 81.8 In-house 52-291 (302) alignment
Range on Protein: 132-371
Range on HMM: 52-291/302.0
ITKNRYQDVPCQDLSAVKLDQpSPCNYIHANYVGCPMIPeKRFICAQGPLDQTI---DEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGEKLTL
. ||. .|||. |   |||.. .| .|..|  |  | .  .  | || |  ..    .||| || |.|. ..|.| .. |. |    ...|  .|. .. 
lkknqsedvpildsnlvklea.epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

KSgCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLqwTEWPDRGVPPCKLTSLELLSAI----RGSKVPIVVHCSAGIGRTGTIVAIEYILEKI
..   | |   .|  |   .  | .|   .|    ..| .|  | |..  ||    .  .    .      .. ..|.    |.|| |....    .||.
gk.mfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavekl

AENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKE
 ..   | . |.||..| ||. ....  || ......| |...| ..
qkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 132-243 6.2e-19 62.9 In-house 48-175 (350) alignment
Range on Protein: 132-243
Range on HMM: 48-175/350.0
ITKNRYQDVPCQDLSAVKLD-----------QPSPCNYIHANYVGCP-----MIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCA
 .||||...   . | |||              |. .|| |||.  .     . |. ..| .|.|| .|.|.|. ....|||. |..| . ||..  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPAAQGEKLTLKSGCVVENVSGSKPM
.||.  . .. |.|     ||. | . .
rYWqegsydditvklaskwenimginds

Y_phosphatase Protein-tyrosine phosphatase 133-363 1.4e-71 236.0 Pfam-A 3-235 (235) alignment
Range on Protein: 133-363
Range on HMM: 3-235/235.0
TKNRYQDVPCQDLSAVKL-DQPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSg
.||||.|... | . ||| ....|..||.||||      .|.||..||||..||..||.||.|.||. ||||.. .|.|. ||||||| ...|.|| .. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd.

CVVENVsgSKPMERDPEIQITMLNLTYSGGQT--MSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKIA
  ||..  .|  | . |.... |.|. .....   .|..|..|.|||.||| ..   |.|. ... ||     |.|||||||.|||||.||....||.. 
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

ENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
...  . . ..|| || ||. ..|.  || |.....|.
aeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 133-363 1.4e-71 236.0 In-house 3-235 (235) alignment
Range on Protein: 133-363
Range on HMM: 3-235/235.0
TKNRYQDVPCQDLSAVKL-DQPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSg
.||||.|... | . ||| ....|..||.||||      .|.||..||||..||..||.||.|.||. ||||.. .|.|. ||||||| ...|.|| .. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd.

CVVENVsgSKPMERDPEIQITMLNLTYSGGQT--MSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKIA
  ||..  .|  | . |.... |.|. .....   .|..|..|.|||.||| ..   |.|. ... ||     |.|||||||.|||||.||....||.. 
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

ENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
...  . . ..|| || ||. ..|.  || |.....|.
aeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

0045098 (Phosphotyrosine protein) phosphatases II 133-367 6.1e-66 217.9 In-house 35-274 (278) alignment
Range on Protein: 133-367
Range on HMM: 35-274/278.0
TKNRYQDVPCQDLSAVKldqpspcNYIHANYVGCPmiPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqgEKLTLKSGC
 |||| |... | | ||       .||.|.|. ..  | |.||..||||..|.. || |. ..... ||||.. ||.|. |||||||    ..     . 
dknRykdilpydhsrVk.......dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggsltygdf

VVENVSGSKPmerdPEIQITMLNLTY-----SGGQTMSVRHLQWTEWPDRGVPPCK--LTSLELLSAIRG-----------------SKVPIVVHCSAGI
.|...| .      ... ...|..|.     ...... |.||... ||| |||.       ||||  ||                  |. |..||||||.
tvtllseevl....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

GRTGTIVAIEYILEKIaenKPCPPMPELVKALRDQRAF-SIQNDVQYLFIHRVMLNYFLE
|||||.||. ..|| .   ..   ..| || || || . ..||  || |.....| ..| 
gRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 133-357 2.5e-47 156.1 In-house 52-273 (301) alignment
Range on Protein: 133-357
Range on HMM: 52-273/301.0
TKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC
 |.||. |||.  .||.. .      ||||..  .  | .|||..||||..| ..|| |..| .||.||||...||  . ||..| |   .||| ..   
dkhryptvPckPstavevivdGkrvPihanwiptsGhp.hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfk

VveNVSGSKPMERDPEIQITmLNLTYSGG--QTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPC
.  ..  .. . ..  .. | |... | |  .| .| | |..||.|||||  .    .|.  .. |. ||||||||||||. . .. ||.  .. |..| 
i..kiknkelilnkkiskrt.levedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarev.eadpt

PPMPELVKALRDQRAFSIQNDVQYLFI
  . | .| ||..|  ..|.  |  ..
ieltealkhlrehrwngvqtnsqlywm

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 133-365 1.1e-46 154.1 In-house 11-242 (250) alignment
Range on Protein: 133-365
Range on HMM: 11-242/250.0
TKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLkCAQYWPAAQGEKLtlk
 |||| |.   | | | | . .    ..|| | ..   .   | || .|||| .|| .|| ||...|.. |||| . .|..|  . ||||. . ||    
eknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky...

sGCV-VENVSgsKpmERDPEIQITMLNLTYSGGQ-TMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK-----VPIVVHCSAGIGRTGTIVAIEYILE
 | | |.  |  |  |   ..... | |.    .    ||.|... |||.|||    . ||||. .. |.      |..|.||||.||.|. .||. .||
.Gdvtvslls..k..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

KIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
.. ..|    . ...|.|| .|  ...   || |.....|.. 
rlkkekvv.dvfkvikvlrkdrphavesleqyvfvyeiilkal

0041856 (Phosphotyrosine protein) phosphatases II 133-369 7.5e-43 141.6 In-house 3-175 (182) alignment
Range on Protein: 133-369
Range on HMM: 3-175/182.0
TKNRYQDVPCQDLSAvkldqpsPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCktvemgklkCAQYWPaaqgekltlksgc
.||||.|... | |        ...||.||.. ... . . ||..||||..|. .|. |. ....  ||.|.         . .|||             
dknrysdilpydhsr.......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

vvenvsgskpmerdpeiqitmlnltysGGQTMSVRHLQWTEWPDRGVPPcKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKiaenkpCPP
                              .  . ..... ||| |||.   . |... ... .. |..||||||.|||||.||. .....        .
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......gvs

MPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
..| || .| .|  ....  || |.....| ..| |.
leeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 133-362 5.5e-37 122.2 In-house 5-236 (237) alignment
Range on Protein: 133-362
Range on HMM: 5-236/237.0
TKNRYQDVPCQDLSAVKLDQP-SPCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKltlKSG
 |||| .. . | | | |  . | ..|| |.|.       |..|.|||||. . |.|| || |.|   ||||   .|  .||| .||| ..  .     |
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ayg

cvVENVSGSKPmERDPEIQITMLNLTYSGGQ--TMSVRHLQWTEWPDRGVPPCKLTSLELLSAI-RG-----SKVPIVVHCSAGIGRTGTIVAIEYILEK
  |  ||  |  |   .  .  | |.. . .     .   |.| |||||||    . | .   |           | ..|||||.|||| .. |. .| .
..vltvslkkk.eefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVML
  |.|    . . |... ..| . ||   ||.|||...|
akekk.vvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 133-365 9.1e-37 121.6 In-house 49-278 (287) alignment
Range on Protein: 133-365
Range on HMM: 49-278/287.0
TKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC
 |||....  .|   | | .  | .|| | ..      .|.|| |..|. .|. .|| .. ...|. |||||.  |  . .| ||||  .   |   .  
dknRltqilvpdnyrvllkgehp.dyinavfidg.ykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeynie

VVENVSGSKPMERdpEIQITMLNltySGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSA-----IRGSKVPIVVHCSAGIGRTGTIVAIEYILEKiAEN
....   .. .||  .....  |   . |.. .|.  | |.|...|  ... |.| ..        . .. .||||||...||... .|..  ..| ...
llneevnagyier..klevknkn...kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink.ckt

KPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
     . ...|  | |.  |.|   || ||  ..|.| 
eGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 133-366 1e-23 78.7 In-house 35-260 (267) alignment
Range on Protein: 133-366
Range on HMM: 35-260/267.0
TKNRYQDVPCQDLSAVKLDQpSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTvEMGklKCAQYWPAAQGEKLTLKSGc
 .||..|.   | . | | . .  .|| | || .    .. ||  |.||..|| .|. .....||  ||.| |.  ..  .  ..||   |.    .   
ernrlddnlpyddtrvilrt.keeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkv.ftd..nirlfwPPkmgqakkyqdl.

VVENvSGSKpmeRDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLE-LL--SAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKp
.||  |  |    . . ||  |.| .    .  |    . .|         |  |  .|    .     |.||.||.|.||.|| . |.  ||.. ..  
tveh.slek...eendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakteg.

CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
   . .... .|.||   ..   .|..||... .|  
vsdifdflrkirsqriglvdtkeryiyihellaeyae

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 135-372 6.4e-39 128.5 In-house 47-283 (312) alignment
Range on Protein: 135-372
Range on HMM: 47-283/312.0
NRYQDVPCQDLSAVKLDQPSpCNYIHANYVGCPMIPEkRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGeKLTLKSGCV-
||| .. | |     |       |||||.|     || ||.|.||||..|.  || ...      |..||  || |  |||.|     |  . |.   | 
nrypniqcwdrgrftlagde.nfyihanfvkictkpe.rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdledhrvy

----VENVSGSKPmeRDpEIQITMLN-LTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENK
     |   | |   .|  |   .|. .  . ||   . | ||. ||| |.|    |.| ||||..  | |.. |||||.|||||.. || ..  .   .
teycteieiggks..kd.kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr

PCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEK
    . .    || .|| |..   ||..  |..|...  |   |
kq.nvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 146-236 2.1e-14 47.6 In-house 80-171 (349) alignment
Range on Protein: 146-236
Range on HMM: 80-171/349.0
SAVKLDQPSPCNYIHANYVGCPMI-PEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVEN
|  . |   . .|| |||.  . | .||..|. | ||  |.|.|. ... |.|. .. | .  | .  || .||   . .  |.|     ..
stsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnssly

subfamily_CG7180_pd Subfamily CG7180 150-367 5.4e-27 89.2 In-house 64-292 (296) alignment
Range on Protein: 150-367
Range on HMM: 64-292/296.0
LDQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEI
||  .  .|| | ||   .. .| .|  ..| ..|.|||| .| ..... .|.|.|| .. | .. .|||  . |.       .||. . ..   |   .
ldGeeksdYinavyvds.flkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkl

QITMLNLT----YSGGQTMSVRHLQWTEWPD-RGVPPCKLTSLELLSAIRG--SK-------VPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPE
. ... ||        .|  |...|.|||.    ||    . .||.  .|    |        |.||..| | .|.|  .||.  ||.. ... .  . |
tkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekee.evdvFe

LVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
 || || .|   ..|  .| .|  |.|...| 
avktlrrsRpqLvenveeYkyiYdvlleavlc

0046846 (Phosphotyrosine protein) phosphatases II 152-365 1.1e-40 134.6 In-house 8-173 (176) alignment
Range on Protein: 152-365
Range on HMM: 8-173/176.0
QPSPCNYIHANYVGCPmipekRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLtlksgcvvenvsgskpmerdpeiqi
 . ...||.||.. ..     |.|. |||| .|. .|. |. ..... .|.|.. ||.|.|||..|||  .....                         
ldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

tmlnltysggqtmsvrHLQWTEWPDRGVPPCkLTSLELLSAIRGSK---VPIVVHCSAGIGRTGTIVAIEYILEkiaenKPCPPMPELVKALRDQRA-FS
                . ... ||| |||.     |||| .||       |..||||||||||||.||.  .       . . .. | .. .|.||  ..
................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplga

IQNDVQYLFIHRVMLNYF
.|.. || |.....| ..
vqtpeQyrflyefellll

0044763 (Phosphotyrosine protein) phosphatases II 153-365 1.2e-28 95.3 In-house 15-171 (178) alignment
Range on Protein: 153-365
Range on HMM: 15-171/178.0
PSPCNYIHANYVGcpmipEKRFICAQGPldqtiDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGekltlksgcvvenvsgskpmerdpeiqit
.  . ||.|...      .  ......|      ... .. ....  ||.|....|.|.||| .|||   |                             
lersdyinaseil.....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

mlnltysggqtmsvRHLQWTEWPDRGVPPCKLTSLELLSAIR----GSKVPIVVHCSAGIGRTGTIVAIEYILEKiaenkpCPPMPELVKALRDQRAfSI
               . ... .|| |||.     ||.. .|.     .. |..||||||.||.||.||. ....         ...| .. .| .|   .
..............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.iv

QNDVQYLFIHRVMLNYF
.|. |. ..... | ..
pnpgqlrqLyefelrll

0043147 (Phosphotyrosine protein) phosphatases II 156-358 8.7e-38 125.1 In-house 5-154 (172) alignment
Range on Protein: 156-358
Range on HMM: 5-154/172.0
CNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTvemgklkcaqywpaaqgekltlksgcvvenvsgskpmerdpeiqitmln
..||.|.|. .. || . ||. ||||. |...|| |. ....  ||.|..                                                  
sdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.................................................

LTYSGGQTMSVRHLQWTEWPDRGVPpCKLTSLELLSAIRG-----SKVPIVVHCSAGIGRTGTIVAIEYILEKIaenkpcpPMPELVKALRDQRAFSIQN
|..  . . .. ..... ||| |||      ||.|. |.      .. |..||||||.|||||.||. ..|...       .. | |. .|..|  ..||
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl.......sleeavalvrekRpgavqn

DVQYLFIH
. || |..
psqyrfly

0051429 (Phosphotyrosine protein) phosphatases II 157-380 1.4e-45 151.3 In-house 5-240 (272) alignment
Range on Protein: 157-380
Range on HMM: 5-240/272.0
NYIHANYVGCP--MIPEKRFICAQGPLDQTIDEFWWMvIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENV-------SGSKPMERDP
.||.|..|| .  .. ..|.....|||. |...||..  ....  ||.|....|.|.||| .||| ..   | . . .. .           |. .  | 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

EIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKltSLELLSAIRGsKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPP-------MPELVKAL
 .   .| |..| |... |.||..| |||.|||.     ||||....  . |..||||||..||||.||. ..|. . ..  .         . | |. |
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

RDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAALLTAE
|.||. ..|.. ||||.....|... . .  ....||.| 
raqrpgavqteeqylflyeallellrsllsvraeyllaal

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 157-375 5.6e-41 135.6 In-house 47-269 (290) alignment
Range on Protein: 157-375
Range on HMM: 47-269/290.0
NYIHANYVGCPMipEKRFICAQGPLDQT-------IDEFWWMVIQNKVEQIVMLCKTVEMGK----LKCAQYWPAAQGEKLTLKSGCVvENvsgsKPMER
.|||||.| ||     |.|  | |. ..       | .||||. | ||.|.||||.  |  .      ||.| | . ||.|..|   | .     | .| 
dyiHAnrvtcpn..glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv.kC....kskek

DPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRA
. ....  | ... ... . | | .  .| .. |.. ..| |.|.. .. || |..|||  || |  .. ||.    |||| .    . ...|||| |||
eddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

FSIQNDVQYLFIHRVMLNYFLEKYKEKYAA
  |... .. |.  ... .. | ... .  
laitsalelafvdagivllaievldqfaee

0036282 (Phosphotyrosine protein) phosphatases II 157-359 2.3e-39 130.2 In-house 3-164 (174) alignment
Range on Protein: 157-359
Range on HMM: 3-164/174.0
NYIHANYVGCPMIPEkRFICAQGPLDqtideFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqgekltlksgcvvenvsgskpmerdpeiqitmlnl
.||.|....  .|.. |.|. ||||.     || |. ..... .|||.. .|.|. || .|||                                     
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tYSGGQTMSVRHLQWTEWPDRGVPPCKLtSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAenKPCPPMPELVKALRDQRAFSIQND
 ..   . .. ..... |||.|||.     ||......       . |..||||||.|||||.||. ..|  .    .     .||..|| ||  ..|..
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp

VQYLFIHR
 || |.. 
sQyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 157-361 5e-30 99.5 In-house 4-149 (151) alignment
Range on Protein: 157-361
Range on HMM: 4-149/151.0
NYIHANYVGcpmipeKRFICAQGPLDqtidEFWWMVIQNKVEQIVMLCKTVEMGklKCAQYWPAAQgekltlksgcvvenvsgskpmerdpeiqitmlnl
.||...||.       .... .|||.    .|. .. ....  ||.|....|.|  .|..|.|...                                  
dyinfsyvt......gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

tysggqtMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-KVPIVVHCSAGIGRTGTIVAIEYILEKiaenkpcPPMPELVKALRDQRAFSIQNDVQYL
       . |.|.... ||| |.| .  . ||.|....   . |..||||||.|||||.||.  .|..        .. | .. .| .|  ..|   |.|
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

FIHRVM
|.....
fqlfal

0049260 (Phosphotyrosine protein) phosphatases II 171-358 3.8e-35 116.2 In-house 8-143 (152) alignment
Range on Protein: 171-358
Range on HMM: 8-143/152.0
EKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWpaaqgekltlksgcvvenvsgskpmerdpeiqitmlnltysggqtmsvrHLQ
 ..||..|||...|...|| |. ....  ||||.. .|.|||||.||.                                                 . .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qyl

WTEWPDRGVPPCKLTSLELLSAI----RGSKVPIVVHCSAGIGRTGTIVAIEYILekiaenkPCPPMPELVKALRDQRAFSIQNDVQYLFIH
.. ||| |||.     |.|| .|    . .. |..||||||.|||||.||. ..|          .. | |. .| .|  ...|  |. |..
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 171-359 5.3e-15 50.1 In-house 4-198 (199) alignment
Range on Protein: 171-359
Range on HMM: 4-198/199.0
EKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVenvsgSKPMERDPEIQITMLNLT---YSGGQTMSVR
..|.|..| || .|. .|| || .    .|||.       .   . |||...       | .|.     .| .   |.  || | ||    .   |  . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt.....tktittkpdytitaliltnnttappstreis

HLQWTEWPDRGVPPCKLTSLELLSAIRGS-------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPC-PPMPELVKALRDQRAFSIQNDVQYLFIHR
| |.| | ..  |   |    ....   |         |..|||| | | || .||..  .    | |     . |. | ||. |   |    .| ||..
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq





subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 171-374 2.2e-06 20.5 In-house 114-318 (346) alignment
Range on Protein: 171-374
Range on HMM: 114-318/346.0
EKRFICAQGPL---DQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKsgCVVENVSgSKpMERDP-EIQITMLNLTYSGGQTMSV
|...| || |    .  ...||.|. |.... . ..     . .   . .     | . | |   ...|   .  .  || |  | .|    |      |
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgk..mfinnrr.ad.vsgdpkeytievlpegnsdsvicqv

RHLqwTEWPDRGVPPCKLTSL----ELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVML
 |   . |     ||  |  .    ..||  .  .. . |    | ||. ...   | .... .|   | . |..|....||  ...   ||  |. ...
hhh..apwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainql.nngiepniceimknikqqrpggvesfaqyasiyaivf

NYFLEKYKEKYA
.|   |   | |
dyiarkrggkka

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 172-359 5.5e-15 50.1 In-house 4-197 (198) alignment
Range on Protein: 172-359
Range on HMM: 4-197/198.0
KRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVenvsgSKPMERDPEIQITMLNLT---YSGGQTMSVRH
.|.|..| || .|. .|| || .    .|||.       .   . |||...       | .|.     .| .   |.  || | ||    .   |  . |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt.....tktittkpdytitaliltnnttappstreish

LQWTEWPDRGVPPCKLTSLELLSAIRGS-------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPC-PPMPELVKALRDQRAFSIQNDVQYLFIHR
 |.| | ..  |   |    ....   |         |..|||| | | || .||..  .    | |     . |. | ||. |   |    .| ||..
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-245 1.3e-06 22.0 In-house 237-303 (440) alignment
Range on Protein: 173-245
Range on HMM: 237-303/440.0
RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKtveMGKLKCAQYWPAAQgEKLTLksGCVVENVSGSKPMER
 ||..| ||| |. .|| .| . ..  |.|| .   .    |. |||      .|.  |       ||. |.|
afiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvnt.rsvtf..gpftvghkgsenmnr

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 180-370 1.7e-25 84.1 In-house 99-293 (302) alignment
Range on Protein: 180-370
Range on HMM: 99-293/302.0
PLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVvENVSGSKPMERD-PEIQITMLNL-----TYSGGQTMSVRHLQWTE
|  .|.. .| .. | .|  .| ||. || .. |||.|.    |..|...  .| . ||  . .|.     .... ..          . ..|  |... 
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytv.ktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYK
||| | |    |.|..|      |  ..||||||.|||||.||| | ..  ...|    . ..|. .|. |  ..|.. | ...  ..   ..||  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkk.vtdllsivlpvrqcryGavqdeqqliylllcvtkglmekag

subfamily_hpo-7_pd Subfamily hpo-7 181-372 5.2e-26 86.1 In-house 43-234 (263) alignment
Range on Protein: 181-372
Range on HMM: 43-234/263.0
LDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNltysGGQTMSVRHLQWTEWPDRGVP
| ||||.|. .. |.| |..||||   | |. || .|.|  . ||. |.   |.   . |... .  |.  |. .      .|  |.| ... |...  |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge....KkkthtvkhysykgWiekndp

PCKLTSLELLSAIRGSKvPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPP-----MPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEK
     .|..| . |.|| ..|||||.||||.   . .| .  |.  .    .       .|.. || .|. .|.. .|  |   ..|...|. . . 
elareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakg

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 184-374 9.7e-28 91.9 In-house 40-232 (255) alignment
Range on Protein: 184-374
Range on HMM: 40-232/255.0
TIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIqitmlNLTYS-GGQTMSVRHLQWTEWPDRGVPPC
|.|.|. ...|.| |..||||   | |. || .|.|  . ||| |.   |.   | .... |  ||      .|..   .|  |.| ... |...  |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei.....tstlgekkkthtvkhysykGWieknaPel

KLTSLELLSAIRGSKvPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPP-----MPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL--EKYKEKYA
    |..| ..| || ..|||||.||||. . | .|..  |.  .    .       .|.. || .|. .|.. .|  |   ..|...   .....|| 
areilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleakyq

0048076 (Phosphotyrosine protein) phosphatases II 249-362 5.1e-21 70.3 In-house 28-140 (145) alignment
Range on Protein: 249-362
Range on HMM: 28-140/145.0
IQITM-LNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS---KVPIVVHCSAGIGRTGTIVAIEYILEkiaenkPCPPMPELVKALRDQ
 .||. ||||.   . .  . ..... |||.|||.   . ||.| .|.     . |..||||||.|||||.||.  .|.         ...| .. .| |
lgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsq

RAFSIQNDVQYLFIHRVML
| ....|. |. |.... |
rpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 255-359 4.9e-20 67.2 In-house 48-139 (144) alignment
Range on Protein: 255-359
Range on HMM: 48-139/144.0
NltysggqtmsVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS---KVPIVVHCSAGIGRTGTIVAIEYILekiaenKPCPPMPELVKALRDQRAFSIQND
.          . ..... |||.|||.     ||.| .|.     . |..||||||.|||||.||.  ..      |   .. | .. .| .| ....|.
e..........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnp

VQYLFIHR
 |. |...
gqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 259-365 1.3e-12 41.8 In-house 84-194 (440) alignment
Range on Protein: 259-365
Range on HMM: 84-194/440.0
SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQ
.| .. .... ..  |||.|||      |...  .  |     . |..|||||| |||| |.|.. || .   .     .  .....|..|   .|   |
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqtpeq

YLFIHRVMLNYF
| |.| ..|. .
yafvheavlegl

PTPc_DSPc_SM00012 266-362 8.4e-30 98.5 In-house 2-104 (105) alignment
Range on Protein: 266-362
Range on HMM: 2-104/105.0
VRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKV------PIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHR
|.|...|.||| |||      |||| |.. .|       |.|||||||.|||||.||....|... ... .. . ..||.||.||. ..|.. ||||..|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VML
..|
all

0038934 (Phosphotyrosine protein) phosphatases II 271-317 6.8e-08 27.9 In-house 84-135 (194) alignment
Range on Protein: 271-317
Range on HMM: 84-135/194.0
WTEWPDRGVPPCKLTSLELLSAI-----RGSKVPIVVHCSAGIGRTGTIVAI
   .||.|..|   . |. |...     . ..  ..||| ||.|||||.|| 
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

PTEN_1 272-316 7.3e-08 27.4 In-house 100-149 (196) alignment
Range on Protein: 272-316
Range on HMM: 100-149/196.0
TEWPDRGVPPCKLTSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVA
 ...| |.|.      .. |.|        .  ..||| ||.||.||.||
fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 281-365 1.5e-08 28.6 In-house 256-338 (347) alignment
Range on Protein: 281-365
Range on HMM: 256-338/347.0
PCKLTSLELLSAIrGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| | .|  |.. . . . |.|| |  |. |. |.|    |.|.. . |  |   .| | .|||||  .   . | .  |  | |.
pvkesstslianl.eklapvvvmcdlgldrsatvvltsiiieqvldgk.tpdcddlfkkmrdqragvftmsifytyairaalfyl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 286-364 1.9e-13 44.9 In-house 217-294 (297) alignment
Range on Protein: 286-364
Range on HMM: 217-294/297.0
SLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
 || | |    .....||||||.||.| .|  . ||.|.  .|  | .  ... ||.|||  .|   |. ... ..|. 
qleslraemprnayllvhcsaGvGrsGvvvlsdvilakl.rkkripdvaailsilreqrarlvqtleqfellydavlkk

DSPc Dual specificity phosphatase, catalytic domain 288-323 2e-06 22.7 Pfam-A 64-98 (133) alignment
Range on Protein: 288-323
Range on HMM: 64-98/133.0
ELLSAIRGSKVPIVVHCSAGIGRTGTIVaIEYILEK
| ..... ..  ..||| ||| |..|.. | |....
efiekaeqkgkkvlVHCqaGisRSatli.iaYlmkt

DSPc Dual specificity phosphatase, catalytic domain 288-323 2e-06 22.7 In-house 64-98 (133) alignment
Range on Protein: 288-323
Range on HMM: 64-98/133.0
ELLSAIRGSKVPIVVHCSAGIGRTGTIVaIEYILEK
| ..... ..  ..||| ||| |..|.. | |....
efiekaeqkgkkvlVHCqaGisRSatli.iaYlmkt

PTPc_motif_SM00404 288-351 5.5e-06 21.3 In-house 71-127 (140) alignment
Range on Protein: 288-351
Range on HMM: 71-127/140.0
ELLSAIRGSKVPIVVHCSAGIGRTGTIVAIeYILEKiaENKpcpPMPELVKALRDQRaFSIQND
. ..... ..  ..||| ||. |..|...  |....  ..     . | .......|  .|.  
dfienaekkggkvlVHCqaGvSRSatliia.Ylmry..rql...slaeayefvkerR.piispn

subfamily_CG42327_pd Subfamily CG42327 291-364 1.5e-16 55.0 In-house 241-314 (319) alignment
Range on Protein: 291-364
Range on HMM: 241-314/319.0
SAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
|. | |. |.||||| |.||||...| .  .... |.|    .|.||  .| .|| ....  || ||..|. .|
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 296-365 1.3e-12 42.1 In-house 261-344 (350) alignment
Range on Protein: 296-365
Range on HMM: 261-344/350.0
SKVPIVVHCSAGIGRTGTIVAIEYILE------KIA--------ENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
   ||.||||||.|||||.|.....|.      ..          .|   ..  .|. || ||   .||  |..||.  .|.||
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 297-365 7.5e-09 29.4 In-house 265-344 (349) alignment
Range on Protein: 297-365
Range on HMM: 265-344/349.0
KVPIVVHCSAGIGRTGTIVAIEYILE----------KIA-ENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
  ...|||||| ||||..| ....|.          ||  ...   ..   |  || ||   .||  |. .|.  .|.||
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_PTPDC1_pd Subfamily PTPDC1 297-359 6.6e-07 23.9 In-house 114-170 (182) alignment
Range on Protein: 297-359
Range on HMM: 114-170/182.0
KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpcppmpELVKALRDQRAFSIQNDVQYLFIHR
.  . ||| || |||| ..|   .  |  . .      . .| .|..|. |||   |  ... 
egkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvke

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 300-361 1.3e-09 32.3 In-house 1-61 (69) alignment
Range on Protein: 300-361
Range on HMM: 1-61/69.0
IVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVM
.|||||.| |||||..||   . .|  .|    . . |. .|  |   . |...|.|||  .
mvvhcssgtgrtgtfiaimvemarikseklvd.ifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 301-361 9.7e-09 29.5 In-house 1-60 (69) alignment
Range on Protein: 301-361
Range on HMM: 1-60/69.0
VVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVM
|||||.| ||||| .||   . .|  .|    . . |. .|  |   . |. .|.|||  .
vvhcssGtGrtGtfiaimvemarikseklvd.ifnnvqymrkcrpmmvmneneymfihdal