Gene F38H4.4 in Caenorhabditis elegans

Synonym: CELE_F38H4.4, F38H4.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf16
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP079_AA protein Get Run
CeleP079_AA_184-458 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051299 (Phosphotyrosine protein) phosphatases II 178-457 1.2e-52 174.5 In-house 1-286 (288) alignment 
Range on Protein: 178-457
Range on HMM: 1-286/288.0
GNTEEKKQKWLGLAKRFVDEDANIAANDFEQVVSYI-PPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLEL-DTQKRAILTQLP
|.|| . ...| | ....  . .. .. ||...|.. ..... .....|..|||. |....|||.|.||      .|.||.|||... ..... |.|| |
gdteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

LPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS------NGDYKSFLHIHHYNAWPHNN
||.| .|||.|. ||.|...  | .  |..    .  .|  ...|.... ...  . .    .|.... .. |.       .... . ...|| .||...
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

IP--GNGSPKFVKQIWQLQSvlrkySPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
.|   .   .|...... ..     |.. |.| ..  |.||.|||.. ....  |. |  ..|. . ....|. | ...|.. |. ||| .|.|..
vpdspellldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 179-481 1.8e-204 671.9 In-house 1-303 (303) alignment 
Range on Protein: 179-481
Range on HMM: 1-303/303.0
NTEEKKQKWLGLAKRFVDEDANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSDSSYIHASYLELDTQKRAILTQLPLPHTSADFW
..|||||||..||||..|||||||.|.||.||||.||||.|.||||||.||||.||||||||||.|||||||||||||||..|.||||||||.||.||||
iseekkqkwkllakrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfw

QMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPKFVKQIWQ
||||||.||||||||||||||.||||.|||||||||.|||||||||||||||..|||||||.||||||||||||.|||.|||||.||..|||||||||||
qmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq

LQSVLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKLAIPKKPNDEKDKE
|||||||||.|||||||||||||||||||||||||||||||||.||||||||.|||||.||.|||.|||.||||||||.||||.||||||||||||||||
lqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpndekdke

KDK
|||
kdk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 180-459 1.3e-31 104.1 In-house 3-287 (302) alignment 
Range on Protein: 180-459
Range on HMM: 3-287/302.0
TEEKKQKWLGL--AKRFVDE-DANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELD-TQKRAILTQLPLPHT
.||.|.|| .   ||..|.. |.    ..|... .   .    . | ||..||.  || .||.  | |.    ||..|| .|.   ..  ||.|||   .
veeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvds

S---ADFWQMIIEQRVKCVLLLLTDSEYDSlGGDFVFP-RNQDFLNFEErsIRVGEfKRVEIMDGWV--LKVVSVSNGDYKS-FLHIHHYNAWPHNNIPg
.   ..||.|. ..... | .|. . | .    . .|| . .|......  ..|   ..|| ... .  . .  . .|   | .  . . . |.....| 
edsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygk..mfvNn.rkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp.

NGSPKFVKQIWQLqsVLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
    . .|.. ..    .| . . .|| .|  |.||||.|    .|  .|... .       .. .|. | .| ..|.|. ..|  |. .|. 
vkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_eak_pd Subfamily eak 186-458 6.6e-14 46.0 In-house 12-306 (332) alignment 
Range on Protein: 186-458
Range on HMM: 12-306/332.0
KWLGLAKRFVDEDANIAANDFEQVVSYIPP-SVTKHQFVKNMHKNrFADVICLDHSKVHLSDS-----SYIHASYLEL-DTQKRAILTQLPLPHTSADFW
||. . | .. .  |   |  ...  | .  |... . ......|   ...  |. .|.|. |      || || .|. .  .. ||| ..       ||
kwilinknhiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafw

QMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQ-DFLNFEERSIRVGEFKRVEIMDGWVLKvVSVSNGDYKsfLHIHHYNAWPHNNIPG-----------
||..||.  ... || | | .    |  || .  . |.|    .   || . .|..   |. .|. |  ..  .. ...  |   ..|            
qmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrlle.lskGnethr..vlhykvfGwtettlpkyedflalrkvm

--NGSPKFVKQI-WQLQSVLRKYSPSTPT---VYMSLSGCGRAGTFALFETAHLSLHSEQATL-DLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
   | ....      |.|.|.||  . |.   .  |  |  |||.| . .     . . .  |  . . .  |.. |||.     | ||.| .. ...|
kevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
0040438 (Phosphotyrosine protein) phosphatases II 187-480 2.8e-58 193.0 In-house 5-299 (317) alignment 
Range on Protein: 187-480
Range on HMM: 5-299/317.0
WLGLAKRFVDEDANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQ
.| . ....  |...  . ||.. |..... .  ....|..|||. |....|||.|.||.      |.||.||| .    ... |.|| |||.| .|||.
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS--NGDYKSFLHIHHYNAWPHNNIP--GNGSPKFVKQ
|. ||.|.... | .  |..    .  .|  ...|.... .... ...    ..|..| .. |.  ..... .....|| .||. ..|   .   .|...
mvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

IWQLQSvlrkySPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKLAIPKKPNDEK
... ..     .|..|.. ..  |.||.|||.. ....  |. |. ..|. ......|. | .|.|.. |. |.|..|.|... .. .. | ..|    |
vreale.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk

DKEKD
 ....
llipl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 192-460 7e-19 62.6 In-house 16-292 (305) alignment 
Range on Protein: 192-460
Range on HMM: 16-292/305.0
KRFVDEDANIAANDFEQVVSYIPPSVTKHQFVKN------MHKNRFADVICLDHSKVHLS---DSSYIHASYLEL--DTQKRAILTQLPLPHTSADFWQM
.| .|   .   ..| ..  |  | .|.  |  |      . |||..|| | |.| |.|.    | |||| |.      .|| | .| || .|  .|| |
lraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwm

IIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDG---WVLKVVSVSN-GDYKSFLHIHHYNAWPHNNIPgngspKFVKQI
.|...|. ...|    |   |     .|  |         | | .      |.      . .. ..  || |  .   ... ||   .|           
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp.....pcklts

WQLQSVLRKysPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
 .| | .|      | |    .| ||.||    |     .  ..    . . .  .|. | .. ||  |. |.. .. ...|..
lellsairg..skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 193-459 8.1e-23 75.9 In-house 9-279 (307) alignment 
Range on Protein: 193-459
Range on HMM: 9-279/307.0
RFVDEDANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS----DSSYIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVK
| .|   .   ..|...  . | .|| . |  | .|||. || | |.... .      | |||| || . .. |. | .| ||  |  .|| |.|...|.
rtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

CVLLLLTDSEYDSLGGDFVFPRNQDF-LNFEE--RSIRVGEFKRVEI-MDGWVLKVVSVSNGDYKSFLHIHHYNaWphNNIPGNGSPKFVKQIWQLQSVL
.|..|    |   .  .  .| ..   | | |  ..| | ..   ..  |  ...| ..     .    |.|.. |  .| | .| |.       | .  
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlq.w..enwpdrgvpqinltainlleav

RKysPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
|      | |    .| ||.||          . . .   |. | .| .|. | .| |.  |. ... .| |. |.
ry..dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 194-480 1.1e-27 92.2 In-house 28-313 (319) alignment 
Range on Protein: 194-480
Range on HMM: 28-313/319.0
FVDEDANIAANDFEQVVSYIPPsVTKHQ---FVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIE
 .|.| ..   .| ..    ..  .. .     .|  |||. ...  |...| |        | || ||...    ... | .| ||. | ||||.|| |
dfdddltklevefrracklgvn.ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

QRVKCVLLLLtdseyDSLGGDfVFPRNQDfLNFEERSIRVgefKRVEIMDGWVLKVVSVSN-GDYKSFLHI--HHYNAWPHNNIPGNGSPkFVKQIWQLQ
...  ..||           .  .| . .  . |.  ..|   . ||  . .|.. . .|. |  |   .|  .|.  ||.   |  .|. ... . ...
yncstivllt.....kdkcsq.ywplkiv.ikeerfkvkv...dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd.lmrlvkkvr

SVLRKYSPSTPTVYMSLSGCGRAGTFALFEtAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE-HILdnGFCKLAIPKKPNDEKDKEK
 . .|    .. |    .|.||.|..  .. . |.   |.  .|. . .. .|. | .  |.|.|. |.|. | | |..  |.. .|.|  |   ... .
hltskenhranivvhcsaGvGrtGvyivld.vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf..ghsdvampdfpayleelsn

D
.
k
subfamily_PTPRA_pd Subfamily PTPRA 197-458 7e-28 92.5 In-house 29-296 (330) alignment 
Range on Protein: 197-458
Range on HMM: 29-296/330.0
EDANIAANDFEQVVS-YIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKR-AILTQLPLPHTSADFWQMIIEQRVKC
.|..   ..|. . .  |  ..   .  .|..|||. ...  |.|.|.||      .| || ||...   .|   | .| |. .|  |||.|| ||.   
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksat

VLLLLTDSEYDSLGGDFVFPrNQDFLNFEERSIRVGEFKRVE---IMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRK
...|    | .       .| ..  . . .  . | . . ..   . .  | ..   .. . .  ..  |...||.  .| ..    .| . ..... ..
ivmltelkerkeekcaqywP.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG.mlkllkkvkklnqq

YSPsTPTVYMSlSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
..  . .|. | .| ||.|||  ...    ...|.  .|. . .. .|. | .  | . |. |.|  | |. |
sag.pivvhcs.aGvGrtGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 198-457 1.5e-21 71.3 In-house 18-279 (439) alignment 
Range on Protein: 198-457
Range on HMM: 18-279/439.0
DANIAANDFEQVVSYIPP-----SVTKHQFvkNMHKNRFADVICLDHSKVHL------SDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQR
. .|  . ||.. |  |.     |.. ...  .  |||. ||  .||..| |        | || | |..   ..|  | || |  .|. |||...||..
kqeifkeifekinstspdyaciaslaaqey..dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

VKCVLLLL--TDSeYDslggdfVFPRNQDFLnFEERSIRVGefKRVEIMDgWV---LKVVSVS-NGDYKSFLHIHHYNAWPHNNIPGNGSpkFVKQI-WQ
.  .. |    .| |        .| ...   . . ..||   . .|. . .|   .||.    ... .  .   || |||..|.| . |  .| .    
tvtivmltnlves.yk......ywpsdaevc.ygdiavrvd..rnielpn.yvirgfkvfnerdttekertvlqfhyiawpdknvpaqas..hvldflra

LQSVlRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
..|         | |    .| ||.||   .. |   |..|.  .|.   ....|. | .  |.| |. |.|  . | |
insa.ndkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0039614 (Phosphotyrosine protein) phosphatases II 200-458 7.8e-53 175.2 In-house 32-290 (297) alignment 
Range on Protein: 200-458
Range on HMM: 32-290/297.0
NIAANDFEQVVSYIPPsVTKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLELDT--QKRAILTQLPLPHTSADFWQMIIEQRVKCVL
..  ..||...|..|.  .  ....|..|||. |....||| |.|        ||.||.|||..     ... |.|| |||.| .|||.|. ||.|....
tllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

LLLTDSEYDSlGGDFVFPRNQDflNFEERSIRVGEFKRveiMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVLrkySP
 | .  |..    .  .| ...  .... .... ...     ||... . .|.|...  ... ..|  ||....|   .   .|...... .. |   ..
mLtklvelgr.kcaqywpeegg..tygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael...pk

STPTVYMSLSGCGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
..|.. ..  |.||.|||..  ...  |..|  ..|. ......|. | .|.|.. |. |.| .|.|...
ggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 200-458 7e-24 79.5 In-house 23-289 (325) alignment 
Range on Protein: 200-458
Range on HMM: 23-289/325.0
NIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRAI-LTQLPLPHTSADFWQMIIEQRvKCVLLL
.  |..|. . |  . . .     .|. |||| .|. ||.|.| |       .| || ||||. | .|     .| ||..|  |.|..... |   |...
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvv

LTDSEYDSLGGDFVFPRN-QDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSfLHIHHYNAWP---HNNIPGNGSpKFVKQIWQLQSVLRK-YS
|   . .       .|..  .  .|    ...   . .      ||.|  |..|. .| ..  .. .|.    .. |      ... . ...  ..    
lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrs.vkqfqlqswddmGvqkrpatli.silqlvkavservtantk

PSTPTVYMSLSGCGRAGTFALFETAHLSLhSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 ||| .    .| ||.|.|. . .|   .  |.. .|. . .. .|. |    .   |....|. |.| ..
astpilvhcsaGvGrtGvfislysalakv.ieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
0043336 (Phosphotyrosine protein) phosphatases II 201-457 4.4e-51 169.4 In-house 21-277 (278) alignment 
Range on Protein: 201-457
Range on HMM: 21-277/278.0
IAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLL
.  ..||.. |. ... .  ....|..|||. |....||| |.||.      |.||.|||...   ... |.|| |||.| .|||.|. |..|.... | 
llllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLt

TDSEYDSLGGDFVFPrnQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS--NGDYKSFLHIHHYNAWPHNNIPGnGSP---KFVKQIWQLQSvlrkySP
.. |... . .  .|  ...|.... .... ...    .|.... .  |.    ... . ...|| .||....|        .|.|.... ..     ..
elvelgrvkcaqYwp..ggsltygdftvtllkeeh...lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreale.....ds

STPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
..|.. ..  |.||.|||.. ....  |..|. ..|| ......|. | .|.|.. |. |.| .|.|..
ngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 201-461 3e-25 83.5 In-house 29-283 (290) alignment 
Range on Protein: 201-461
Range on HMM: 29-283/290.0
IAANDFEQVVSYIPPSV-TKHQFVKNM--HKNRFADVICLDHSKVHLSDS---SYIHASYLElDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLT
.| . .|... |.|     .. | ||   .|||. ||.| | ..| |.|     |.|| |..  ..   |||| .|  |  |.|.|.....|  . .|  
lakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk.GlkamfiltqGalkdtvidiwrmvlqekvaaivmlce

DSEYDSLGGDFVFPRN-QDFLNFEERSIRVGEFKRV-EIMDGWVLKVVSVSNGDYKSFLHIhHYNAWPHNNIPGNGspkfvKQIWQLQSVLRKYspSTPT
  |      .  .| .  . | | | ..   | .   . .   .| |  . .|  . . |. .  .|| . ..          . ..  .|||   | | 
liedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhl.kikswpdksvalst.....lallrtlrilrka..sGpv

VYMSLSGCGRAGTFALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQfsfvYTLLAEHILDNG
|    .| ||.|||.  |..   |  .   |||..    .|| |. . |  .|    | .| | .|| |
vvhcsaGiGrtGtfvaievglqill.dGkeldlldlvralrnsrlnsvqvdiq....ylalveilldlG
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 201-458 6.9e-18 59.5 In-house 10-267 (283) alignment 
Range on Protein: 201-458
Range on HMM: 10-267/283.0
IAANDFEQVVsyIPPSVTK-HQFVKNMHKNRFADVICLDHSKVHLSDS--SYIHASYLE----LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLL
.  . ....   .|.  .. .   .| .|||. ...  |  .|.|     .|| |...      . .|. | .| || .|  |||.|. .... ....| 
lfrevlkrls..vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

TDSEYDSLGGDFVFPRNqDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSN-GDYKSFLHIHHYNAWPHNNI-PGNGSPKFVKqIWQLQSvLRKYSPSTP
   |         .|..    .. |  . . .       . .. | . . . .  || | . ||      .. ..     .|| . ...| |.. |. .|
klqedlrikCsqyWPkr.GsedyGeftvtlrkett...snsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvis.lqteskkgP

TVYMSLSGCGRAGTFALFETAHLSLHSeQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 |    .| ||...|    ..   . . .. .|. . ....|. |. | |.| |. .|..|  |. |
ivvhCstgiGrtavfiaasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 202-457 2.5e-27 90.8 In-house 25-283 (319) alignment 
Range on Protein: 202-457
Range on HMM: 25-283/319.0
AANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLT
 ...|...    . .... .  .| .|||. ...  |...| ||      .| || ||...   .... | || || .|  |||.|. |... .|..|  
lekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

DSEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRVEIMDGWVLKVvSVSNGDY-KSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSpSTPTV
..|   .    ..|. ..| .. .  . . | .. | .    ||.    ...     .  ..|..|| ...| ..    .. . ...   .| . | | |
lveklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekat.slldllkrirksrektq.sgPiv

YMSLSGCGRAGTFALFEtAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
     | || |||   . | |   .|...||. .   ..|  |    |.  |..|.|  | | .
vhCsaGvGRtGtfivld.amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 202-454 2.2e-21 70.8 In-house 9-266 (281) alignment 
Range on Protein: 202-454
Range on HMM: 9-266/281.0
AANDFEQVVSYIP---PSV--TKHQFVKNMHKNRFADVICLDHSKVHLSD-------SSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKC
. .||.| .| .|   ||   |  .   | .|||.... ||| |.|.|         . |||| |.     ||  |||| |   | ||||.|| ..   .
tlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentta

VLLLLTDSEYDSLGGDFVFPRNQD-FLNFEERSIRvgeFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNgSPKFVKqiwqlqsVLRKY-
...|    | .       ||||    |.|.. |.    ..   .    |   . .|      ..    .. ||  ..|.  |  ..|       .|||  
ivmlcqfletnrekcaeyfprnahcclqfdklsvs...yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpes.sevmlk.......ilrkir

SPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVR-NGRIHACQNLTQFSFVYTLLA
. ||| |    .| ||.||.   | |  |.||  .  |. . .  .|  ||  . | | |. ... .| 
arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
0045098 (Phosphotyrosine protein) phosphatases II 204-458 5.4e-50 165.7 In-house 12-273 (278) alignment 
Range on Protein: 204-458
Range on HMM: 12-273/278.0
NDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHlsdsSYIHASYLELDtQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGG
  ..... .|| ..| .....|..|||. |....||| |.     ||.|||..   .|. |.|| |||.| ||||.|. |....... | .  |..    
efefllllgipseitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

DFVFPRnQDFLNFEERSIRVGEFKRVEIMDGWVLKVVSV---SNGDYKSFLHIHHYNAWPHNNIPGNG----SPKFVKQIWQLQSVLRKY--------SP
.  .|  ...|.... .... ...... .  ..|.|. .    ..... .....||  || ...| .       .....| . ...| ..        ..
aqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

STPTVYMSLSGCGRAGTFALFETAHLSLhseQATLDLVKCLEMVRNGRIH-ACQNLTQFSFVYTLLAEHIL
..|..     |.||.||...  .    |   . ..|| ......|. | . |.||| |. |.| .|.|..|
ggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRG_pd Subfamily PTPRG 204-458 1.2e-26 88.1 In-house 23-288 (563) alignment 
Range on Protein: 204-458
Range on HMM: 23-288/563.0
NDFEQVVSYIPPS---VTKHQFVKNMHKNRFADVICLDHSKVHLSD-----SS--YIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLlL
..||...| . ..   ... |  .| .|||  ...  |.|.|.||.     ..  || |.|..    .|  | || ||..|  |||.|| ||.|. .  .
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv.m

LTD-SEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRVEIMDG--WVLKVVSVSNG---DYKSFLHIHHYNAWPHNNIPGNGSPKFVkqIWQLQSVLrKY
.|.  |      |  .|. .. ..... ...  | ... .      |.| . . ..   |..     .||  ||  . |    |.      . .|   . 
itnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLi..fvkkssaa.nk

SPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
.   |.|    .| ||.||.  ..| .  ...|. . .. . | ..|  | .  |.  |. |..  | | |.
aeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_PTPRN_pd Subfamily PTPRN 204-457 1.9e-20 67.8 In-house 33-292 (297) alignment 
Range on Protein: 204-457
Range on HMM: 33-292/297.0
NDFEQVVSYIPPSVTK--HQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYL-ELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLL
...| ...|     ||   .  ||..||| ..|.  |||.|.|.      .| || || . . | .. | | || ||..| ||||||. || |  .. | 
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

TDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVE--IMDGWVLKVVSVSngDYKSfLHIHHYNAWPHNNIPGNgsPKFVKQ-IWQLQSVLRKysPST
. .| .    .  .| .   .        | |    .  ..  . || .  |  . .. .   |. .||....| .  .| . .   ...   |    |.
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts..etrt.vtqfhflswpeegvPas..aksllefrrkvnksyrG..rsc

PTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
| |  . .|.||.|.. | .     |      .|..  || .|. | .  .   || |..| .|| .
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
0046845 (Phosphotyrosine protein) phosphatases II 205-459 2.1e-52 173.6 In-house 5-276 (284) alignment 
Range on Protein: 205-459
Range on HMM: 5-276/284.0
DFEQVVSYIPP---SVTKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLEL------DTQKRAILTQLPLPHTSADFWQMIIEQRVKC
.||...|. ..   |..  ....|..|||. |....|||.|.|       .||.||.|||..       ...|. |.|| |||.| .|||.|. ||.|..
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSN---GDYKSFLHIHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRK
.  | .  |..    .. .| ....|.... .... . .    .|.... .....|   ...  .....|| .||....| . .  ... .......|..
IVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvpps.pedlleflrlvrellen

YSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQA--TLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
.... |.| ..  |.||.|||.. ....  |. |.   ..|. ... ..|. | .. |.| |. ||| .|.|... 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 205-458 6.1e-30 99.4 In-house 25-281 (318) alignment 
Range on Protein: 205-458
Range on HMM: 25-281/318.0
DFEQVVSyIPPSVTKH--QFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTD
..|..    . .||..      | .|||.|...  ||..|.|.      .| || |.|..  ..|.| | .| |||.|  |||.|. ||  . ...|   
eyerlsr.seetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

SEYDSLGGDFVFPRNQDfLNFEErsIRVGEFKRVEiMDGWVLKVVSVSNGDYKSF--LHIHHYNAWPHNNIPGNGsPKFVKQIWQLQSVLRKYSpSTPTV
.|      .  .| ..   ....  ..|   ..|| .. .||. ..|.. . ..    . .|| .|| ...| .|  .... . | ... .| .  .|.|
eergkakvhryWPskgs.rsygk..lvvelkeeve.lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaqqksg.agpiv

YMSLSGCGRAGTFALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
    .| ||.|.|   ..    .. ..|..|. .  ...|. |    |   |. |.|. | | . 
vhCsaGvGrtGvfiavdillerik.aealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 205-457 9.3e-23 75.8 In-house 27-283 (305) alignment 
Range on Protein: 205-457
Range on HMM: 27-283/305.0
DFEQVVSYiPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSE
.......  . |.  ..  .| .|||..... ||.....|.      || || |||..    .|. |..| ||..| ||||..|.| .|. ...|    |
qykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

YDSLGGDFVFPRNQDF-LNFEERSIRVGEFKRveiMDGWVLKVVSVSN--GDYKSF-LHIHHYNAWPHnnipgNGSPKFVKQIWQL-QSVLRKYSPS--T
 .       .| ..    .|.| |. . ..|    . ... . ...|.  .| .|  .  ..   ||      .| |.|   . .| . | .... .  .
ggkdkCrqYWpesktekkefgefsvelksekt...asdyieRklkisiededkesrtvlqyqltdWPd.....hGvpqfatsllslikrvqkdqkkdkgv

PTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
| .     | ||.|.|   . |   |. |. ..|. . |  .|. |. . |.| |. |..  |.| |
pllVhCsagvgRtGvfiavdialerlkkEe.vvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Ptp69D_pd Subfamily Ptp69D 205-457 2.8e-22 74.2 In-house 27-286 (307) alignment 
Range on Protein: 205-457
Range on HMM: 27-286/307.0
DFEQVV-SYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDS
..|..  . |. | .  .   |  |||. |..  |. .| |.      ||.|| ||...  . .|. |  | |.  |  |||.|| || |. . .|   .
eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlt

EYDSLGGDFVFPRNqDFLNFEerSIRVgEFKRVEIMDGWVLKVVSVSNGD-----YKSFLHI--HHYNAWPHNNIPGN--GSPKFVKQIWQLQSVLrkys
|..    .  .| . |  ...  .| | .. . | .. .. . ..||. .      .   ..  .||..|.  ..|    |  |...|. .|..      
eknrkkcakYWpie.devqyg..dilv.klvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln....

pSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
  .| |     | ||.|.|  ..     |. |. ..|...    .|. |    |.| |..|.|  |....
.rsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPRD_pd Subfamily PTPRD 206-457 6.6e-33 109.2 In-house 29-281 (564) alignment 
Range on Protein: 206-457
Range on HMM: 29-281/564.0
FEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEY
.... .    .... .   | .|||.|...  ||| | |      ..| || ||...  ...|  | || ||..| .|||.|. ||..... .|   .| 
ykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk

DSLGGDFVFPRNQdFLNFEERSIRVGEFKRVEIMDGWVLKVvSVSNGDYKSFLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSvlrkySPSTPTVYMS
.    .  .| ..   ...|  . . | .... .    .|. . .. . .   .  |. .||....| .. .  ...... .|..     . . |.|   
gkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.....pdagPivVhC

LSGCGRAGTFALFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
 .| || |||   .   |    |..|.|. ......|. | .  |. .|..|... ..| .
SaGVGRTGtfividam.lerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 206-462 6.5e-27 89.2 In-house 16-275 (285) alignment 
Range on Protein: 206-462
Range on HMM: 16-275/285.0
FEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELDT--QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSL
 ...  |.|| .|   .  |   ||.||| |.. ..| |   |  |||||.. .    |   | || ||| | .|||.|| ....  ||.| |  |    
qdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggve

GGDFVFPRN-QDFLNFEERSIRVGEFKRvEIMDGWVLKVVSVSNGDYKS--FLHIHHYN--AWPHNNIPGNGSPkfvkqIWQLQSVLRKYSPS-TPTVYM
   . .| .  . ..| .  | . | |  | . | .|. ..| | .  |   |.. | .   || .  | .  |     . .|   ..|  |  .| .  
kcalyypeklgevvkfgkyeitltecke.eaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarp.....mielykwvkkvnpkekpicvh

SLSGCGRAGTFALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGF
  .| ||. ||   . | . .  |.  ....  .  .|  |..| |.  || |.| .| |... .| 
csagvgrtatfvgidyatirim.enpniemldivremramrfqavqshmqflflyvvlmeyfigegv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 206-456 8.1e-20 65.9 In-house 12-258 (267) alignment 
Range on Protein: 206-456
Range on HMM: 12-258/267.0
FEQVVSYIPP--SVTKHQFVKNMHKNRFADVICLDHSKVHLSDS--SYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKcVLLLLTDSEYDS
||..    .    ...    ||  .||. |..  |...| |...   || |||.|   |..  |.|| ||  | .||...|..|.|  |  ||| .  | 
felikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp.vivlltkvftdn

LGgDFVFPRNQDFLNFEERSIRVGefKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWphnNIPGNGSPkFVKQIWQLQSVLRKYSPSTPTVYMSLSGC
.   |  |.  .  .... ..        |  |  .. .    . .    . ...|. |   ||  |  | ..| .. . .  .    . | |     | 
ir.lfwPPkmgqakkyqdltvehs..lekeendyqiitlelkfknesahnvtlyyykkw...nintnnkp.ylkplfgilaknqlengnrPlvvacsdGv

GRAGTFALFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
||.|||   ..  |    .. ..|. . |  .|. ||   . . .. ... ||||.
GrsGtflvidsq.leraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 206-292 6.1e-11 36.4 In-house 18-116 (347) alignment 
Range on Protein: 206-292
Range on HMM: 18-116/347.0
FEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD-----------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLL
 |.. .| |. .|  .. |.. |||  ||   | ..| ||             .|| ||.. .|  .|  |||| |||.|  |||.|.   .|  |. .
denlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0045450 (Phosphotyrosine protein) phosphatases II 207-459 2.9e-52 173.7 In-house 37-306 (307) alignment 
Range on Protein: 207-459
Range on HMM: 37-306/307.0
EQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLELD---------TQKRAILTQLPLPHTSADFWQMIIEQRVKCVL
 .|  ... . .  ....|..|||. |....||. |.|       .||.||.|||  ..          ... |.|| |||.| .|||.|. ||.|....
lsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtviv

LLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS---NGDYKSFLHIHHYNAWPHNNIPG--NGSPKFVKQIWQlqsVLRK
 | .. |...   .  .| ....|....  ... ...    .||... .. |.     ..  .....|| .||. ..|   .   .|......   .|..
mltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk...alee

YSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQAT--LDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
.....|.. ..  |.||.|||..  ..   |..|. .  .|| ......|. | .|.||. |. |.| .|.|..|.
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 208-299 1.7e-11 38.2 In-house 78-175 (244) alignment 
Range on Protein: 208-299
Range on HMM: 78-175/244.0
QVVSYIPPSVTKHQFVK-NMHKNRFADVICLDHSKVHLSDSS----YIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD
| .    ||| |  |   | .||| .  . .| ..| || .|    || ||..  |      |||| ||  || |||.|..|. |. ...| .  | |
qniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed
0050432 (Phosphotyrosine protein) phosphatases II 209-458 1.2e-51 171.3 In-house 51-300 (308) alignment 
Range on Protein: 209-458
Range on HMM: 51-300/308.0
VVSYI-PPSVTKHQFVKNMHKNRFADVICLDHSKVHLS-DSSYIHASYLEL---DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGG
. |.  ... .  ....|..|||. |....||| |.|. .|.||.|||  .   . ... |.|| |||.| .|||.|. ||.|...  | .  |..    
llsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekc

DFVFPRN--QDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNNIPGNgspkfVKQIWQLQSVLRKYSPSTPTVYMSLSG
.  .| .  ...|...  .... . .    .|.... .. ..|  ...  .... || .||. ..| .     .......   .||. |. |.| ..  |
aqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhytnWpdhgvPps.....peilldflelvrkslpggpivVHCsaG

CGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
.||.|||.. ....  |. |  ..|. ... ..|  | .. |.. |. |.| .|.|...
vGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 210-455 5.8e-18 59.9 In-house 32-276 (287) alignment 
Range on Protein: 210-455
Range on HMM: 32-276/287.0
VSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD--SSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFV
|.  . .||     .| .|||.....  |  .| | .    || |....    .|. |... |. .|  .||..| ...|. ...|  . | |       
vtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

FPRNQDfLNFEERSIRVGEFKrveIMDGWVLKVVSVSN---GDYKSFLHIHHYNAWPHNN-IPGNGspKFVKQIWQLQSVLRKYSpSTPTVYMSLSGCGR
.| ..  . . | .|.. . .   ...|.. . . | |    . |  .. ... .|. .  ..       . .| .     || .  |. |     . ||
Wpeeks.vvlGeyniellnee...vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq..tillvieemyktqrkrg.ntsivvhCsdtvGr

AGTFALFETAHLSLhSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
...|   .|.      .. ..|... |.  |  . .. |  .|. |.. .. |
samfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivle
DSPc_SM00195 212-456 1.4e-52 174.0 In-house 13-261 (263) alignment 
Range on Protein: 212-456
Range on HMM: 13-261/263.0
YIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGD
. | ..|. .. ||..|||. .... ||..|.|..      |.||.|.|....  .|. |.|| |||.| .|||.|..|..||... |  ..| ..   |
tspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

FVFPRN-QDFLNFEERSIRVGEFKRVEimDGWVLKVVSVSNGD--YKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVLrkyspSTPTVYMSLSG
  .|.. ..  .|.. |. . | . ..  | ..|....... .   . ... ..|..||....|   .   ...... . .|       |.|.| ..  |
rywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpivVhCsaG

CGRAGTFALFETAHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
.||.|||.. ...  .|..|.  .|. ......|. |....|.|.|..|.|. ..| 
vgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 212-456 1.4e-52 174.0 In-house 13-261 (263) alignment 
Range on Protein: 212-456
Range on HMM: 13-261/263.0
YIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGD
. | ..|. .. ||..|||. .... ||..|.|..      |.||.|.|....  .|. |.|| |||.| .|||.|..|..||... |  ..| ..   |
tspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

FVFPRN-QDFLNFEERSIRVGEFKRVEimDGWVLKVVSVSNGD--YKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVLrkyspSTPTVYMSLSG
  .|.. ..  .|.. |. . | . ..  | ..|....... .   . ... ..|..||....|   .   ...... . .|       |.|.| ..  |
rywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpivVhCsaG

CGRAGTFALFETAHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
.||.|||.. ...  .|..|.  .|. ......|. |....|.|.|..|.|. ..| 
vgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
0047943 (Phosphotyrosine protein) phosphatases II 212-457 2.4e-49 163.6 In-house 24-272 (273) alignment 
Range on Protein: 212-457
Range on HMM: 24-272/273.0
YI-PPSVTKHQFVKNMHKNRFADVICLDHSKVHL--SDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVF
.. . . .  ....|..|||. |....||| |.|  ..|.||.|||... ..... |.|| |||.| .|||.|. ||.|...  | .. | .    .  .
lkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PRNQD--FLNFEERSIRVGEFKRveiMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNNIPGnGSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRA
| ...  .|.... .... . .     |.... .. ..|   ... . ...||  || ...|      ... |......|...  ..|.| ..  |.||.
pleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvpp.slesllefielvrkalealpsngpvvVHCsaGvgRt

GTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
|||.. ....  |. |  ..|. ... ..|. | .. |.. |. |.| .|.|..
gtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 213-467 2.3e-55 183.4 In-house 27-287 (297) alignment 
Range on Protein: 213-467
Range on HMM: 27-287/297.0
IPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSDSS--YIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR
...| .  ....|..|||. |....||. |.|.|..  ||.|||...   ... |.|| |||.| .|||.|. ||.|.... | .. |..    .  .| 
llgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpl

N-QDFLNFEERSIRVGEFKRVeIMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNNIPGnGSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTF
. ...|.... .... ... | . |...| .. |..  .... .....||  ||....|      ... |.....||... ...|.. ..  |.||.|||
eegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.spaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtf

ALFETAHLSLHS--EQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKLAI
.. ....  |..  .. ..|..... ..|. | .|.|.| |. |.| .|.|... . ..  ..
iaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll
subfamily_ptpA1_pd Subfamily ptpA1 213-407 5e-15 50.1 In-house 34-247 (418) alignment 
Range on Protein: 213-407
Range on HMM: 34-247/418.0
IPPSVTKH-QFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDF
. || |   .  .|  |||..... ..|..|.|        | || | |..    |. | || ||| | ||||.|. |.|.. ...|  .||   .  | 
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

VFPRNQ---DFLNFEERSIRVGEF--KRVEIMDGWVLKVV----SV-SNGDYKSfLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVL-RKYSPSTPT
 .| .    .|  . .    .| .  . ||...    ...     .  .|. .  .  ..|. ||  |||    |  .... | . |  .        | 
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd.itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

VYMSLSGCGRAGTFA
.    .| ||.|||.
ivhcsagvgrtgtfc
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 214-293 2.3e-18 60.8 In-house 41-126 (310) alignment 
Range on Protein: 214-293
Range on HMM: 41-126/310.0
PPSVTKHQFVKNMHKNRFADVICLDHSKVHLS-D----SSYIHASYLELDTQKR-AILTQLPLPHTSADFWQMIIEQRVKCVLLLL
 .|.| . . |.|||||..||.||| |.|.|  |      |||| |.  .  .   | .| || ||  |||.||...| . .||| 
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc
0049772 (Phosphotyrosine protein) phosphatases II 215-456 7e-25 83.8 In-house 36-279 (314) alignment 
Range on Protein: 215-456
Range on HMM: 36-279/314.0
PSVTKHQFVKNMHKNRFADVICLDhSKVHL-----SDSSYIHASYLelDTQKRAILTQLPLPHTSADF----------WQMIIEQRVKCVLLL-------
 .... ....|..|||. |... | . |.|     |.|.||.|||.  |. .. | || ||..|  ||          |.|....  ..  .        
ltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyv..dgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

----------------LTDSEYDslggDFVFPRNQDFLNfeersirvgefkrveimdgwvlkvvSVS--NGDYKSF-LHIHHYnawphnNIPGNGSPkFV
                |. ...     ..  ......|.                         ..   . ...   .. ...      ..|... |   
adelsrLdaAlgKtpllildgng....neptaadlellk.........................eelydpelferlgikylri......pvpDgsap.ll

KQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALfeTAHLSLHSeqaTLDLVKCLEMVRNGRI-----HACQNLTQFSFVYTLLAEH
......  ....... .|..    .|.||.|||..  .| | ..     ..| ..||.||. |      .. ..| |. |..  | |.
edfdeflefieeadkggpvlvHCkaGkgRtgtfvv..aaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 215-455 8e-18 59.3 In-house 36-281 (290) alignment 
Range on Protein: 215-455
Range on HMM: 36-281/290.0
PSVTKHQFVKNMHKNRFADVICLDHSKVHLS------D--SSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDF
 .||     .| ..||||...  |  .. |       |   .||.|.|..    .|. |.|| |...| .|||..| ...| ....|..  | ..     
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

VFPRNqDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNiPGNGSPKFVKQIWQLQSVLRKYSpSTPTVYMSLSGCGRAGT
 .| . |  ...| ||.. . . .. .    |.| . .....|. .. ..  .|...    .     . .| . .   ||    |. |     . ||...
YWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgrsav

FALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
|   .|.    ..|.   |... |.  |  .    |   |. ...... .
fcaaattinkckteg.vidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 215-465 2.3e-15 51.1 In-house 33-284 (312) alignment 
Range on Protein: 215-465
Range on HMM: 33-284/312.0
PSVTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQ
.      |.|    ||. .. | |  .  |.  .  |||| .. . |.  | . || ||  |.. |||. .     ...|| .  |  |           
sdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv

DFLNFEERSIRVGEFKRVEI-------MDGWVLKVVSVSNGDyKSFLHIHHYNAWPHNnipgnGSPKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAG
 |...|.  .       .||       .   |||||  . |. .| |  . . .||       | |  .    .| | ..|     | .    .| ||.|
gfvdledhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwaswpdh.....gmpdscdtalrllsavkkd..kkpviahcsagvgrtg

TFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKL
|.|| |.   .|   .   .. . . ..|. |  . . . |. ..   . | .  .|. | 
tlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykr
subfamily_PTPRB_pd Subfamily PTPRB 216-455 1e-31 105.1 In-house 42-283 (293) alignment 
Range on Protein: 216-455
Range on HMM: 42-283/293.0
SVTKHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP
.|.. .  .|  |||. ...  |||.|.|      |.| || |.|..  . ..  | || |||.|  |||.|. |.... ...|    |      .  .|
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

RNQDFLNFEErsIRVgEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFAL
....  .. .  |.| ...  | .. ||.. ....... .  .. .|. .||  ..| . . .... . .......| . ..|.|    .| ||.|||  
adeepvlyGd..ikv.tlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektk.tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfia

FETAHLSLHSeQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 ..   .... . ..|..  .  .|. | .  |. .|. |... . .
ldrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_PTPN1_pd Subfamily PTPN1 217-455 3.8e-32 106.2 In-house 24-269 (290) alignment 
Range on Protein: 217-455
Range on HMM: 24-269/290.0
VTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQD-
... .. .|  .||. ||   |||...|   |  || || .||.  ... |||| |||.| . ||||. ||. |.|..|    | ...     .|.... 
treaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

-FLNFEERSIRVgEFKRVEIMDGWVLKVVSVSN---GDYKSFLHiHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFAL
  | .|. ...| .. . |. . ...... . |    . .. || .|| .||   .|     .|.| ......     |   |.|    .| ||.|||.|
kellledtklkv.kliseerksyytvrllelenlktqetreilh.fhyttwpdfgvpes.paaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

FETAHLSLHSEQA--TLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|  . .. ..   ..|. | |  .|. |.   |   |. | |. . |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN3_pd Subfamily PTPN3 217-450 3.6e-31 103.1 In-house 33-268 (280) alignment 
Range on Protein: 217-450
Range on HMM: 33-268/280.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSDSS--YIHASYLELDTQK-----RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR
... .  .|..|||. |..  |. .|.|..|.  || |.|.... .      | | || ||..|..|||||. ||... ...| |  |         .|.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

NQDFLNFEERSIRVGEFkrvEIMDGWVLKVVSVSNGDYKSFLHIHH--YNAWPHNNIPGNgSPKFVKQIWQLQSVlrKYSPSTPTVYMSLSGCGRAGTFA
..| |.. | |... .    .    .||. . ... . |   .|..  | ||| ...| . | .|.. . .....  . . ..|.|    .| ||.| . 
tedeleygefsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd.sadflefvervrkl..rsgkeePvvvhCsaGigrtGvli

LFETAHLsLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVY
|.|||   |  ..  .  .. . ..|. |    |. .|. || 
lletala.lieaaepvypldivrtmrdqramlvqtasqykfvC
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 217-460 8.8e-28 92.2 In-house 39-282 (288) alignment 
Range on Protein: 217-460
Range on HMM: 39-282/288.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR
||. .  .| .|||. ... .|. .|.| .      . || |||.. . .| . | || ||..|  |||... |.... .. |    | .    .  .| 
vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd

NQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFALF
...  |. .  . . | |    .. .||. . .     .  .. ..| ||| ...| .  | ... . |..    .   . | .     | ||.|||   
adkpknyGsvtvtlveske...ledfvlrklllekkkteleitqyqylaWpdhgvPeskap.llellrqvkvanqad..tgpiivhCsaGvGrtgtFial

ETAHLSLHSeQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
...   ... . ..|..  .. .|. |    |.|.|. |.|  |.. | ..
dalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 217-460 4.3e-27 90.0 In-house 45-287 (297) alignment 
Range on Protein: 217-460
Range on HMM: 45-287/297.0
VTKHQFvkNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELdTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFprN
|....   |..|.|.....  | |.|.|       || |. ||...   ..| | || | . | ||||.|.....|. ...|  |.| |     . .  .
vaekkv..nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg.nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWs..d

QDFLNFEERSIRVgefKRVEIMDGWVLKVVSVSNGD--YKSFLHIHHYNAWPHNNIPG-NGSPKFVKQIWQLQSVLRKYSPStPTVYMSLSGCGRAGTFA
.   .| . |. .   . |.   | . . ..|..|.   . ... ...  ||.....  .  ....| | ... .  . . . | .   |.| ||.| . 
kgvttfGdvsvvl...lsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvll

LFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
  .   ..   .. ..|. . ....|. | .  |   |..||| .. | .| .
tidsv.vaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 217-449 1.1e-14 48.9 In-house 42-273 (301) alignment 
Range on Protein: 217-449
Range on HMM: 42-273/301.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSDS---SYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLG-GDFVFPRNQ
.|. .   . .|.|.  | |  .. |.. .      ||| ... .   .| | || ||. || ||| |..   |. . .|    |.      ...  . .
itesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

DFLNFEERSIRVGEFKRVeIMDGWVLKVVSV--SNGDYKSFlHIHHYNawpHNNIPGNGSPKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFAlf
. |. .  .|.. . . . . .  . . . |  | |....   . ||.   ... . .| ||   ....|  ...|     | |    .| ||. .|   
ekldigrfkikiknkeli.lnkkiskrtlevedstgkfatr.tvthyq...ysewtdrgvPkshaelfdlmelvkks..ekPivvhcsaGiGrsvafi..

ETAHLSLHSE-QATLDLVKCLEMVRNGRIHACQNLTQFSFV
 |  |. . | . |..| . |. .|. | .. |. .|. ..
gteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 217-291 1.4e-07 25.3 In-house 26-106 (332) alignment 
Range on Protein: 217-291
Range on HMM: 26-106/332.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSD----SSYIHASYLELDTQKRA-ILTQLPL-PHTSADFWQMIIEQRVKCVLL
 |  .|..||  ||   . |.|||.| |.       .  ||...  ..| | |..| |.  ||   ||.|. |..   .|.
ntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilv
0040439 (Phosphotyrosine protein) phosphatases II 218-458 2.1e-46 154.0 In-house 4-247 (249) alignment 
Range on Protein: 218-458
Range on HMM: 4-247/249.0
TKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRn
.  ....|..|||. |....||| |.||.      |.||.|||...   ..| |.|| |||.| .|||.|. |....... | .. |..  . .  .|  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

QDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSNGDYKSFLHIHHYN--AWPHNNIP--GNGSPKFVKQIWQLQSVLrkySPSTPTVYMSLSGCGRAGTF
...|.... .... ...    .|.... .. ..|  ... ....|..   ||. ..|   .   .|...... .. |   ....|.. ..  |.||.|||
ggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtf

ALFETAHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
..  ...  |. |.  .||  .....|. | .|.||. |. |.| .|.|..|
iaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 218-456 1.1e-22 75.5 In-house 21-267 (274) alignment 
Range on Protein: 218-456
Range on HMM: 21-267/274.0
TKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLEL-DT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP
 ...  .. .|||. ...  ..|.| |       .||||| | |.   |. .|  . || |||.| ||||.|| ...|. ...|   .| .       ||
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

RNQDF-LNFEERSIRVGEFKrVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRK-YSPSTPTVYMSLSGCGRAGTF
 ..|. .. .   . .   | .   ... .. .....   .  .. . | .|| .. | . . .... . . ..  ..   . .|.|    .| ||.| |
daedyeiserygdveikvek.iverndysvrklvlkylerersvkhywytdWPdhksPddan.tlldlvleveesreeenaklapvvvhCsaGiGrtGcf

ALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
   . |   |. |. ..|..|    .|  |    |.  |. ...  |...
iaisiavrqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 218-458 2.7e-19 63.8 In-house 38-237 (392) alignment 
Range on Protein: 218-458
Range on HMM: 38-237/392.0
TKHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYL-ELDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDslggdfvfprn
|  |   |..|||. ... .| ..|.|      .|| |. |||.  .|..|  | .| | . .  |||.|. ...|  . ..    | |           
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

qdflnfeersirvgefkrveimdgwvlkvvsvsNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSpsTPTVYMSLSGCGRAGTFALFE
                                 .|| .     .|.  || ...|   |  ..| | ....   .|.   | .    .| ||.|     .
.................................kgddartvaqfhftewPdkdvpkhts.sllkfikevkadfGqyt..hpliihcsagvgrtgvvisid

TAhlSLHS-EQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
.     |. .   .|... .  .|. | .  |   |..|.|  . | .|
sv..vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 218-297 7.9e-09 29.6 In-house 33-121 (301) alignment 
Range on Protein: 218-297
Range on HMM: 33-121/301.0
TKHQFVKNMHKNRFADVICLD--------HSKVHLSDSSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSE
| .   .| . ||| ..  .|        .....|.  .|| |||..    .|. | .| |. .| .|||..|.....  .. .    |
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke
subfamily_PTPN13_pd Subfamily PTPN13 219-453 1.6e-30 101.3 In-house 31-265 (273) alignment 
Range on Protein: 219-453
Range on HMM: 31-265/273.0
KHQFVKNMHKNRFADVICLDHSKVHLSDSS-YIHASYLELDTQK---RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFL
. .  .|..|||. .|.  |...|.|.|.. || ||....  .|   ..|..| |||.| .|||||. ||... . .. .. | . .  .  .| ...  
vgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

NFEERSIRVGEFkRVEIMDGWVLKVVSVSNGDYKSFLHIHHYN--AWPHNNIPGNgSPKFVKQIWQLQSVLRkysPSTPTVYMSLSGCGRAGTFALFETA
   .  ..|    .|. .||.|.. . |.. . .   .. | |  .||  ..| . . .... . ..... .    ..| |    .| ||.||.   ...
lkvsnrlevell.kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss.aaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidvv

hLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLL
 | | . .  .|. . .. .|. |    |   |. |||  .
.lglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 219-456 5.3e-24 79.7 In-house 43-278 (315) alignment 
Range on Protein: 219-456
Range on HMM: 43-278/315.0
KHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLELDTQKR-AILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNq
  . ..| .|||. ..|  |.|.|.|      ..| |. |....  ..||  | .| |.. .  |||... |. .  ...|    | .    .  .| . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

dFLNFEErsIRVGeFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQsVLRKYSPsTPTVYMSLSGCGRAGTFALFET
  . . .  | |   |  |. . .  . .||  ||    .   || .||  ..|    | ... | . . . .. |  .. |    .| ||.|||  ...
.kviyGk..itvt.rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytip.lmnlirtvk.qhhtnsv.gaivvhcsaGvGrtGtfitlda

AHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
    .. |.| .|. . .. ||. ||.. | . |. |.|  | | 
vldqaeaena.idvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 219-460 1e-21 72.2 In-house 37-274 (288) alignment 
Range on Protein: 219-460
Range on HMM: 37-274/288.0
KHQFVKNMHKNRFADVICLDHSKVHLSDSS--YIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLN
 ..|..|  ..|. .. . | ..|.||| .  ||.|  .      .| | .| ||  |   .|.|..|. |. ...|    |      .  || ..    
idsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

FEERSIRVGEFKRVEIMDGWVLKVVSVS-NGDYKSFLHIHHYNAWPHNNIPGNGSPKFvkqiwQLQSVLrkYSPSTPTVYMSLSGCGRAGTFALFETAHL
   |   |   ||..|    .. .. .| .|. | .. | |.. |... .| |  . .     .|  ||   |   | | .|  | ||.||..|   |  
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylspl.....rllevl..kslqkPivvhssaGvGrtgtlililiale

SLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
|| ..   | . . |.  |. | .| |   |. .|. .. |..|  
slrldd.flgirsllaklreerfkaiqtemqylyvhrcvleelllk
0037934 (Phosphotyrosine protein) phosphatases II 220-456 1.1e-45 151.5 In-house 5-241 (243) alignment 
Range on Protein: 220-456
Range on HMM: 5-241/243.0
HQFVKNMHKNRFADVICLDHSKVHLSDSSYIHASYLELDtqKRAILTQLPLPHTSAD----FWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPrnQDFlN
.... |..|||. |....||| |.|..|.||.|.. .    .| |.||.|||.| .|    ||.|. |....... | .. |.. .. .  .|  ... .
allpenlsknrysdilpydhsrvklegsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.t

FEERSIRvgeFKRVEIMDGWVLKVVSVSN---GDYKSFLHIHHYNAWPHNNIPG--NGSPKFVKQIWQLQSV---LRKYSPSTPTVYMSLSGCGRAGTFA
... ...   .. .| .|.... .....|   .|.. . . .|| .||....|   .   .|...... ..    |...... |.. .   |.||.||..
ygdftvt...llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

LFETAHLSLhseqaTLDLVKCLEMVRNGRIH-ACQNLTQFSFVYTLLAEH
.  . .| |     ..|| ......|. | . |.|.. |. |.| .|.|.
aaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 220-455 1.2e-44 147.9 In-house 4-241 (245) alignment 
Range on Protein: 220-455
Range on HMM: 4-241/245.0
HQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnQD
 ....|..|||. |....||. |.||      ||.||.|||  ..   .. |.|| |||.| .|||.|. |....... | .. |..  . .  .|  ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

FLNFEERSIRVGEFKRveiMDGWVLKVVSVS--NGDYKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVlrkySPSTPTVYMSLSGCGRAGTFAL
.|.... .... ...    .|.... ...|.    |.. . . .||  ||....|   .   .|.. ... ..     ....|.. ..  |.||.|||..
sltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsngpvlVHCsaGvgRtGtfia

FETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
  ...  |..|. ...| ......|. | .|.|.. |. |.| .|.|
aylmleqlekel.gvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 220-457 1.2e-30 101.6 In-house 37-290 (297) alignment 
Range on Protein: 220-457
Range on HMM: 37-290/297.0
HQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP-RNQ
 .   |..|||..||.|.|...|.|.       | ||.|....   ||.| | || ||..|. |||.|. ||.|  ...     |   |     .|  ..
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

DFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHiHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVLRK-------YSPSTP-TVYMSLSGCG
.  .| . |... | .  |     ||..  | ... ..  | . . .||   .| ...   ...... . |... |       . || |  |    .| |
ssaefgdlsvsnveveeeedykvrvleiknvkteesrkvth.fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RAGTFALFETAHLSLhSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
|.|||. .. .   |  |..|.|.|......|. | .. |   |. | |  . |. 
rtGtfitldiclsrl.eevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN14_pd Subfamily PTPN14 220-457 1.1e-27 91.8 In-house 44-296 (300) alignment 
Range on Protein: 220-457
Range on HMM: 44-296/300.0
HQFVKNMHKNRFADVICLDHSKVHLSD-----SSYIHASYLELD---TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRN-
 .  .| .|||| ||.  ....|.||      . || || ..     ...  | .| ||..|  |||||. || |. ...|  . |         ||.. 
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

--QDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIhHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRKYSPST-------PTVYMSLSGCG
  .. ..|..  .     .  . .    ||.  .  ..... .|.  |. || ...| .   .|.. . ..||| || . ..       | .   . | |
skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl.qytDWpdhgvPeD.vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
|.|   | .    .|. .  ..|. | |...|. | .  |.|.|. |||..| ...
rtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 220-458 6.6e-22 72.3 In-house 38-277 (515) alignment 
Range on Protein: 220-458
Range on HMM: 38-277/515.0
HQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSL-GGDFvFPR-N
 |   | .|||. ... .| ..| |       .| |. |||.. .|..|  | .| |.. .  |||.......|  . ..   .| |    | . .|   
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky.WPdkp

QDFLNFEerSIRVGEFkRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRKYSpsTPTVYMSLSGCGRAGTFALFE
 | ..|   ||.|     .|   | . . . |  ||    .  .|.. ||.. .| . .  ..| | ....   .|.   | .   ..| ||.| .   .
gdsvkfG..sikvelv.sleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh.tssllklikevkadhgqyt..hpliihcsaGvGrtGvvisid

TAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
   ..   .  ..|. . .. .|. | .  |   |..|.|  . |..|
sv.vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 220-322 1.1e-06 20.4 In-house 24-122 (275) alignment 
Range on Protein: 220-322
Range on HMM: 24-122/275.0
HQFVKNMHKNRFADVICLDHSKVHLSDSSYIHASYLELDTqKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEydsLGGDFVFPRNQDFLNFEER
..|..| .||||..| |.|.   . ..  ..||. .        ...| |   |.||. ...    |. |. |..  |    || ||    . |  |.  
erfirngeknrftnvtcfdeildrenqeffvhantfrtpy.gnflisqapndstnadhlhllwiynvqtvvclvlpee...aggyfvpkegetftsfqky

SIR
 |.
qik
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 221-457 7.7e-28 92.4 In-house 37-276 (281) alignment 
Range on Protein: 221-457
Range on HMM: 37-276/281.0
QFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDF
.  .|..|||. ...  |...|..      ... || |.... .. .|. | || |.|.. ..||||..||.|. . ..  . | . |     .| ..  
kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnse

LNFEERSIRVGEFKRVEIMDGWVLKVvSVSNGDYKSFLHIhHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSPsTPTVYMSLSGCGRAGTFALFETAH
|.. .  ..  . .. . .   ..|. . ..|. ..  .. .| ||| . .| . . ....   ..... .| .  .| |    .| ||.||.  .... 
lkygdvtvkstaeeekatyierkfkl.eresgetreveql.aytaWPdhGvPattk.ellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlv

LSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
 ....|...||.   .. .|. |    | ..|..|||  . . .
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN6_pd Subfamily PTPN6 221-457 1.5e-24 81.5 In-house 50-297 (306) alignment 
Range on Protein: 221-457
Range on HMM: 50-297/306.0
QFVKNMHKNRFADVICLDHSKVHL-----SDSSYIHASYLE---LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQD
. ..|..|||.  ..  ||..| |     ..| || |.|..    ...|. | ||  |..| .|||.|. ..  . .... .. |         .| ...
akpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeee

FLNfeERSIRVGEFKRvEIMDGWVLKVVSVS---NGDYKSFLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVLRKYsPSTPTVYMSLSGCGRAGTFA
  .    .|.| . .  . .. ..|. .|||   ... .  .. .|...|| ...| . .   .|.... . |. |..   . |.|    .| || ||| 
kee..yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea.eagpivvhCsaGiGRtGtfi

LFETA--HLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
. ..    .. .  .| .|. |. ..||. |    |  .|. |||. ....|
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 221-457 2.9e-23 77.2 In-house 16-264 (270) alignment 
Range on Protein: 221-457
Range on HMM: 16-264/270.0
QFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLE--LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQ-
..... . ||.||..   ...| |..      . || | |..   . .|. | .. ||| |  .||.||.|..|......    |      .  .| .. 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DFLNFEERSIRVGEFKRvEIMDGWVLKVVSVS-NGDYKSFLHiHHYNAWPHNNIPGNGS-----PKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGT
. ...|.  |.|   .  | ..|..|. . .  .|. .  .| ..||.|| . .| .        . .| . ... . .. . ..|..     | ||.||
ekvkledgkikvlalse.ekeegyiltrlrleekgeerrlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
. . ..|   |. |.  .|... .| .|. |.   |   |. |.|  ..|..
lialDiavrlLe.etkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 221-458 3e-23 77.2 In-house 40-278 (315) alignment 
Range on Protein: 221-458
Range on HMM: 40-278/315.0
QFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR-NQD
.   |..|||. ... ||...| |       || || |||.. .|..|  | .| ||. .  |||.|.....|  . ..   .| | .     .|  . |
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

FLNFEERSIRVgeFKRVEIMDGWVLKVvSVSNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFALFETA
  .| . .. .  ..     || . |.  . ... .  .  .... ||.. .. . |  ..| | ....  .|.    . .   ..| ||.| .   .  
svefGsikvel..lsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts.sllklikevkadngkk..efsllvhcsaGvGrtGvvisidev

hLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 ..   .. ..|. . ....|. |..  |   ...|.|  . |..|
.vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN12_pd Subfamily PTPN12 222-456 1.7e-32 107.4 In-house 37-276 (290) alignment 
Range on Protein: 222-456
Range on HMM: 37-276/290.0
FVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDF-
  .|..|||. |..  |.|.|.||      .|.|| |....  . ... | .| |||.|  |||.||.|..|. |...    | .    .  .| ...  
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

LNFEERSIRVGEFKRveIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRkySPSTPTVYMSLSGCGRAGTFALFETAH
|.|.| .. . | |.  . |..... . | . . .  ..  ||.|||  ..| .   . .. |...... .  | ..| |    .|.||.||    . ..
lefgefevtleeeka..vdddflirtLkveaqkesrkvyqfhYtaWPDhgvPss.aksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvr

LSLHSEQA--TLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
  |..|.   .||. . .  .|. |  . |   |...||  .|| 
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 222-485 3e-27 90.8 In-house 22-282 (284) alignment 
Range on Protein: 222-485
Range on HMM: 22-282/284.0
FVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLtdseyDSLGGDfVFPRNQDfL
  .|  |||. ...  |...| |        | || ||...    ... | || ||. | ||||.|| |...  ..||      .    .  .| . .  
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsq.ywplkiv.i

NFEERSIRVgefKRVEIMDGWVLKVVSVSN-GDYKSFLHI--HHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALFEt
. |.  ..|   . ||  . .|.. . .|. |  |   .|  .|.  ||.   |  .|. ... . ... . .|    .. |    .|.||.|..  .. 
keerfkvkv...dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsd.lmrlvkkvrhltskenhranivvhcsagvgrtgvyivld.

AHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE-HILdnGFCKLAIPKKPNDEKDKEKDKENED
. |.   |.  .|. . .. .|. | .  |.|.|. |.|. | | |..  |.. .|.|  |   ... .... .|
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf..ghsdvalpdfpayleelsnksdfdd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 222-291 6e-08 26.9 In-house 30-106 (297) alignment 
Range on Protein: 222-291
Range on HMM: 30-106/297.0
FVKNMHKNRFADVICLDHSKVHL----SDSSYIHASYLELDTQK---RAILTQLPLPHTSADFWQMIIEQRVKCVLL
    ..|||. |..  | ..|.|    ... || | |. .  ..   . ||.| ||  |  |||... || |. . .
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivm
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 223-456 3e-32 107.0 In-house 54-289 (298) alignment 
Range on Protein: 223-456
Range on HMM: 54-289/298.0
VKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDfLN
 .| .|||.||.| ||.|.| |..      | || ||.|.  ...   |.|| ||..| .|||.|..|. .... .| .  | | .     .| ..   .
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.et

FEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHyNAWPHNNIPGNGSPkFVKQIWQLQSvLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLS
..| .... . ..   .    ||| . .. . ..  ..|.   || . .| | .   .. . . .   .. .  .| .    .| ||.|||   ..    
ygeitvsllskeefadlivrklkvskkkeekerevrqlhf.tsWpdkgvpenats.vldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvler

LHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
.. || ..|. . ....|. |..| |  .|..|.|..  | 
vkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 223-456 2.3e-30 100.6 In-house 7-241 (250) alignment 
Range on Protein: 223-456
Range on HMM: 7-241/250.0
VKNMHKNRFADVICLDHSKVHLSDSS------YIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLgGDFVFPRNQDFln
 .| .|||.||.| ||.|.| |  ..      || ||.|.  .. |  | || ||..|  |||.|..|. .. ...| . .| .       .| ..    
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae..

fEERSIRVGEFKRVEIMDG--WVLKVVSVSNGDYKSFLHIHhYNAWPHNNIPGNGspKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALFETAH
 .  ...|  ... |  |    .||. . .. | .   ..| . .||   .| .   . | .. .     .... ..| .    .| ||.|.|   ..  
.kyGdvtvsllskeefadytkrklklskakkaderivrqlh.fvvWPdkgvPeva..tavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

LSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
  |. |. ..|. | ....|. |.|| . |.|..|||... . 
erlkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_CG7180_pd Subfamily CG7180 223-460 3.9e-23 76.5 In-house 40-293 (296) alignment 
Range on Protein: 223-460
Range on HMM: 40-293/296.0
VKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNqdFLN
 .|. |||  .|.  |. .| |      ..| || |.| .  ..|.. | |. |  .|  .||... .. ...|  |    ..  .  ... ..     .
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keq

FEERSIRVGEFKRVEIMDGWVLKVVSV--SNGDY-------KSFLHIHHYNAWPH-NNIPGNGSpKFVKQIWQLQSVLRKY---SPSTPTVYMSLSGCGR
. |  . . | |    .  . .|..    . ..        .  ..  ..  |.  ...|   .  ... . . ... .|        |.| .|  | .|
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstn.alielrrrvrlwrekvdedpeegPvvvvssdGasR

AGTFALFEtAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
.| .   . | | | ...  .|. . . ..|. | .  .| ... ..| .| |..| |
sGvylaid.anlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 223-463 2.3e-22 74.1 In-house 46-293 (305) alignment 
Range on Protein: 223-463
Range on HMM: 46-293/305.0
VKNMHKNRFADVICLDHSKVHLSDS---SYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSL-GGDFVFPRNQDFLNFE
 .. .|||. || |||. .|.|  .    |||| |.   |  || | || || .| |||| | ....|. ...|    |  .    ..   ...| |.||
aqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

ERSIRV-------GEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNaWphNNIPGNGSPKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFALFE
|.  ..       ...| ..  .  | . | | .|  .. ... ||  |  .. |  | |     | .|    |      |.|    .| ||.|.  ..|
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyh.w..idwpdrgvpaadlailellekarps..kgpivvhcsagigrtgsvvmle

TAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFC
     | . |   |  | |  .|. |  . |  .|. ||. .. ........ 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 223-455 2.9e-17 57.4 In-house 36-275 (287) alignment 
Range on Protein: 223-455
Range on HMM: 36-275/287.0
VKNMHKNRFADVICLDHSKVHLSD-----SSYIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNF
. ...|||.|||. .|...| ||      |.|| | |.   |. .. | .| |.. |  |||....|.|.  |...  . |   |     .| ..  .  
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

EERSIRVGEFKRVEImDgWVLKVVSVSNGDYKS--FLHIHHYNAWPHNNIPGN--GSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFaLFETA
   |. . ...  |  . .  . . . . . .    ..  .. .|| . ..    |  .|| .. |   . |. |   | |     | ||.|.. |   .
GGysvvlldydikeP.e.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil.latlv

HLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|   .   .|  . .  .|. |    |   |. ..|  |. 
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 223-299 8.6e-11 36.1 In-house 45-142 (350) alignment 
Range on Protein: 223-299
Range on HMM: 45-142/350.0
VKNMHKNRFADVICLDHSKVHLS--------------DSSYIHASYLELD-------TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD
|. . |||. ...  .||.|.|                . || |.||.|        .. . | || ||| |  ||...|..  || .| | .| |..
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_PTPRK_pd Subfamily PTPRK 224-458 1.8e-23 77.9 In-house 42-278 (314) alignment 
Range on Protein: 224-458
Range on HMM: 42-278/314.0
KNMHKNRFADVICLDHSKVHLS----D--SSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFlnF
.| .|||. |..  |.|.| |     |  | || |....  .. .| | || ||..| .|||... ...  ....|    |   .     .| . .   .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..y

EerSIRVgEFKRVEIMDGWVLKVVSVSN--GDYKS--FLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKysPSTPTVYMSLSGCGRAGTFALFETA
.   |.| |. ..|.    | .. .|..    ..    ..  .. .||. ..| .    ..| . ....   .     ..|   ..|.||.|||   .. 
g..dikv.elvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat.gllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidiv

hLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 | .  .. ..|. ..   .|. ..   .   |. |.|  . |  |
.ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 224-452 6.4e-17 56.6 In-house 2-234 (237) alignment 
Range on Protein: 224-452
Range on HMM: 2-234/237.0
KNMHKNRFADVICLDHSKVHL----SDSSYIHASYLE-L-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFE
.|  |||...... |||.| |    |.| || |.||. .  | |. | .| ||  .  |||||. ...   ...|    | . |     .|  ..   . 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

ErsIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIH--HYNAWPHNNIPGNGSP--KFVKQIWQLQsvlRKYSPSTPTVYMSLSGCGRAGTFALFEtAH
   . |   |. |. |  |  .. . ..  |    ||  .. .||.. .| . .   .| |.| .     .. | |.| .    .| ||.| | . . | 
v..ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrs...phvsesgpwiihcsagvgrtgiflvid.am

LSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTL
|    |.  .|. . .  . . | .  |   |. |..  
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_egg_pd Subfamily egg 224-455 2.5e-14 47.7 In-house 39-268 (307) alignment 
Range on Protein: 224-455
Range on HMM: 39-268/307.0
KNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLltDSEYDSLGGDFVFPRN-QDFLN
 |..| |   | | | |.|.|          .||| ... .      ||.| ||  |  |||.|. ...|. ...|  .|  .|   .. .|.  .| | 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml..tsrkeserceyywpkaesdslv

FEERSIRVGEFKRVEIMDGWvLKV--VSVsNGDYKSFLHIHHYNaWPHNNIPGNGSPkfvkqiwqLqSVLRKY-SPSTPTVYMSLSGCGRAGTFALFETA
.   |.|.  .|  .  |   ..|  . .  |  .  ... |.. .  ||     ||        |  ||||    |.|.|  .  |. .|.|.   |.|
tvpGslrienlkvdskadpl.frvtklkl.vGgddeerflehwq.gdvnnssdvysp........l.rvlrklrnlskpvvvqdilGvskaatlvaieia

HLSLHSEQATLDLV-KCLEMVRNGRIHACQNLTQFSFVYTLLAE
 |||     |  || ..  ..|  |  . .   .. ||| |.. 
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
Y_phosphatase Protein-tyrosine phosphatase 225-455 8e-52 171.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 225-455
Range on HMM: 1-235/235.0
NMHKNRFADVICLDHSKVHL----SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP-RNQDFLNFEE
|..|||. |... |...|.|    ..| ||.|.|..  ...|. |.|| ||..| .|||.|.....||.. .| .. | ..   .  .| .....|....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RSIRVGeFKRVEIMDGWVLKVVSVSNGDYKS---FLHIHHYNAWPHNNIPGNgspkfVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFETAH
 ....   |  |......|....... . .|    .. .||..||....| .     .|....|   ..|..   |.|.| ..  |.||.|||.. ... 
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

LSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|..|.  .|........|. |....|.|.|. |.| ...|
eqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 225-455 8e-52 171.4 In-house 1-235 (235) alignment 
Range on Protein: 225-455
Range on HMM: 1-235/235.0
NMHKNRFADVICLDHSKVHL----SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP-RNQDFLNFEE
|..|||. |... |...|.|    ..| ||.|.|..  ...|. |.|| ||..| .|||.|.....||.. .| .. | ..   .  .| .....|....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RSIRVGeFKRVEIMDGWVLKVVSVSNGDYKS---FLHIHHYNAWPHNNIPGNgspkfVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFETAH
 ....   |  |......|....... . .|    .. .||..||....| .     .|....|   ..|..   |.|.| ..  |.||.|||.. ... 
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

LSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|..|.  .|........|. |....|.|.|. |.| ...|
eqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN23_pd Subfamily PTPN23 225-455 1.2e-29 98.1 In-house 43-278 (288) alignment 
Range on Protein: 225-455
Range on HMM: 43-278/288.0
NMHKNRFADVICLDHSKVHLSDS--SYIHASYLELDT--QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQD-FLNFEER
. .|||. |..  ||..|.| .|   || ||...  .      | || ||. |..|||.|. ||... . .||. .| .    |  .| ...   .|.. 
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdl

SIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIhHYNAWPHNNIPGNGS--PKFVKQIWQ-LQSVlrKYSPSTPTVYMSLSGCGRAGTFALFETAHLSL
|. . . .. | .   |||.   ..   ||  |. ....||.  .|   .   .|.... . ...|  .    || |   ..| ||.|.|||  .|   |
svtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeav..qrksktPlvvhCsaGvgRtgvfalvyaavrel

HSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
. ..  ||... .. .|. | .  |. .|. |.|    |
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
0041856 (Phosphotyrosine protein) phosphatases II 225-459 2.1e-24 81.5 In-house 1-173 (182) alignment 
Range on Protein: 225-459
Range on HMM: 1-173/182.0
NMHKNRFADVICLDHSKvhlsDSSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLtDSEYDSlggdfvfprnqdflnfeersirv
|..|||. |... |||     |..||.|...  .    | |.|| ||..| |||..|. |....... |  .  |.                        
nldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywp.......................

gefkrveimdgwvlkvvsvsnGDYKSFLHIHHYNAWPHNNIPGngSPKFVKQIWQLQSvlrkysPSTPTVYMSLSGCGRAGTFALFEtahL---Slhseq
                      ...   . ..|  || ...|    ..... | . ..      .. |..     |.||.||...     |         
.....................ellerlgiqylylpwpDhgvpd..ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay...lmkkl.....

aTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
  ..| .....||. | ...... |. |.. .| |..| 
.gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 225-451 1e-17 59.1 In-house 7-234 (239) alignment 
Range on Protein: 225-451
Range on HMM: 7-234/239.0
NMHKNRFADVICLDHSKVHLS------DSSYIHASYLE-LDTQ-KRAILTQLPLPHTSADFWQMIIEQRvKCVLLLLTDS-EYDSLGGDFVFPRNQ-DFL
|  |||.|...  |||.| |        | || ||||   |   |  | ||  .  .| |||.|. ..| .||...||   |         .| .   . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqer.rcvivmltglieghkkkchqywpdstskyc

NfeersIRVGeFKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNnipgnGSPKFVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFE
|     .||  ... |..  .... . .|.     . ... .|.  || .     | |..   .  |.  . | |   . | |    .| ||.|.| . .
n.....lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk.....gvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

tAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
 | |    .| |.|... .. .|. | |  |   |. |.. 
.amlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 225-451 1.2e-17 58.9 In-house 8-235 (239) alignment 
Range on Protein: 225-451
Range on HMM: 8-235/239.0
NMHKNRFADVICLDHSKVHLS------DSSYIHASYLE-LDTQ-KRAILTQLPLPHTSADFWQMIIEQRvKCVLLLLTDS-EYDSLGGDFVFPRNQ-DFL
|  |||.|...  |||.| |        | || ||||   |   |  | ||  .  .| |||.|. ..| .||...||   |         .| .   . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqer.rcvivmltglieghkkkchqywpdstskyc

NfeersIRVGeFKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNnipgnGSPKFVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFE
|     .||  ... |..  .... . .|.     . ... .|.  || .     | |..   .  |.  . | |   . | |    .| ||.|.| . .
n.....lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk.....gvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

tAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
 | |    .| |.|... .. .|. | |  |   |. |.. 
.amlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_CG42327_pd Subfamily CG42327 225-387 3e-07 24.4 In-house 28-198 (319) alignment 
Range on Protein: 225-387
Range on HMM: 28-198/319.0
NMHKNRFADVICLDHSKVHLS------DSSYIHASYLE--LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD-SLGGDFvFPRNQDFLN
   |.|...|. | ...| |        . |..|||.    |..   | .| .|  .|.|||... ||. . .. |   ||       .. .| ..   |
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaey.lPtketldn

FEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHY-NAWPHNNIPGNGSPkFVKQIWQLQSVLRKYS
 .        .|  |. | ...  . . . | .   .. ||   |.. ..| . .. ..  . . .| |. ||
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaa.liamllevrsslksys
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 233-307 4.1e-09 30.2 In-house 75-152 (349) alignment 
Range on Protein: 233-307
Range on HMM: 75-152/349.0
DVICLDHSKVHL-SDSSYIHASYLEL---DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLlTDSEYDSLGGDFVF
 ||   .|. .      || | ||.|   ...|. | || ||| |  ||...|. ..|| || | .|..  ||.   ..
kvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL.nddkelslekcdiy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 240-299 2.3e-07 25.2 In-house 6-66 (130) alignment 
Range on Protein: 240-299
Range on HMM: 6-66/130.0
SKVHLSDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD
    | .  ||.||.. | .  .  .||| ||  || |||.|..|. |  ...| .  | |
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 241-451 4.9e-10 34.0 In-house 41-253 (290) alignment 
Range on Protein: 241-451
Range on HMM: 41-253/290.0
KVHLSDsSYIHASYLELDTQKRAILTQLPLPHT-------SADFWQMIIEQRVKCVLLLLTDSEYDSLGGDF----VFPRNQD-FLNFEERSIRVgefKR
. ...|  ||||...      | |||| |. ..         .|| |. . .|| |  |   .| ..  ..|     .| . .  |.|.  ...    | 
gkrfnd.dyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC...ks

VEIMDGWVLKVVSVSNGDYKSFLHIHH-YNAWPHNNIPGNgspkfVKQIWQLQSVLRkySPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVK
 |  |.   . . |  .| . |   |. .. | . |.. .      | . .| . ..     || .     |  |  ..|  . .   .   .  . |..
kekeddvetRelvvkfddeeeftvtHsllkgWnklnvqed.....tktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkled

CLEMVRNGRIHACQNLTQFSFVYT
 |...|. | .| .. ....||  
vlkalrkqralaitsalelafvda
0046846 (Phosphotyrosine protein) phosphatases II 244-454 7.8e-19 63.6 In-house 9-170 (176) alignment 
Range on Protein: 244-454
Range on HMM: 9-170/176.0
LSDSSYIHASYLELDtqkRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNfeersirvgefkrveimdgwvlkvvsvs
  |..||.|...  .   | | || |||.| |||..|. |.....|. |... |...|. .  .|. ...                              
dldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

ngdyksflhIHHYNAWPHNNIPGNgsPKFVKQIWQLQSVLRKYspsTPTVYMSLSGCGRAGTFALFEtahlsLHSEQATLDLVKCLEMVRNGRI-HACQN
          ...  || ...|      . . . .....|..     |..     |.||.||...       |   .  |.. ..|..||. |  .| |.
.........qylhlpwpDhgvpdl..elllellefirealkeg...gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqt

LTQFSFVYTLLA
  |  |.|  . 
peQyrflyefel
0051429 (Phosphotyrosine protein) phosphatases II 245-457 1e-21 73.3 In-house 2-225 (272) alignment 
Range on Protein: 245-457
Range on HMM: 2-225/272.0
SDSSYIHASYLELDTQ----KRAILTQLPLPHTSADFWQMiIEQRVKCVLLLLTDSEYDSLGGDFVFP-----------RNQDFLNFEERSIRVGEFKRV
. |.||.|...   ..    .| .... |||.| ||||..  |...|... | ...|...|. |.. |           .   . ..   .... ...  
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

EIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPKFVKQIWQlqsvlrkyspSTPTVYMSLSGCGRAGTFALFETAHlSLHSEQATLD-----
. .  ..| .. ... .    ... || .||  ..| .   ...... .          . | ..   .|..| ||...         |... .|     
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYllt

---LVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
   | ...|..|  | .| |. .|. |.|  |.| .
nlyleeaveelraqrpgavqteeqylflyeallell
0044763 (Phosphotyrosine protein) phosphatases II 245-455 2.4e-11 39.1 In-house 16-169 (178) alignment 
Range on Protein: 245-455
Range on HMM: 16-169/178.0
SDSSYIHASYLEldtqKRAILTQLPLphtsADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDflnfeersirvgefkrveimdgwvlkvvsvsn
  | ||.||.       . .|..||     ||..... |. ..... | .. |.  |. |  .|.. .                                
ersdyinaseil....pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

gdyksflhihhyNAWPHNNIPGNGSPKFVKQIWQLQSVLRKY--SPSTPTVYMSLSGCGRAGTFALFETAHLSlhseqaTLDLVKCLEMVRNGRIhACQN
              . | .||..| |   ......   ....  ..  |..     | ||.||...    .         |.| ...|.||. |  ...|
............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivpn

LTQFSFVYTLLAE
  |  ..| .  .
pgqlrqLyefelr
0043147 (Phosphotyrosine protein) phosphatases II 246-450 2.3e-17 58.7 In-house 4-154 (172) alignment 
Range on Protein: 246-450
Range on HMM: 4-154/172.0
DSSYIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDseydslggdfvfprnqdflnfeersirvgefkrveimdgwvlkvvsvsn
.| ||.||||.|    .| | || ||..| ||||.|. |. ..... | .                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

gDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLR---KYSPSTPTVYMSLSGCGRAGTFALFETAHlslhseqATLDLVKCLEMVRNGRIHACQ
  |   |  ...  . . ..| .| |   ...... . ..     ||. |..     |.||.||...    .         |.| .....||. | .|.|
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavq

NLTQFSFVY
|  |  |.|
npsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 247-450 1.6e-15 52.7 In-house 2-163 (174) alignment 
Range on Protein: 247-450
Range on HMM: 2-163/174.0
SSYIHASYLELDTQ-KRAILTQLPLPhtsadFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnqdflnfeersirvgefkrveimdgwvlkvvsvSNG
|.||.||.| |    .| |..| ||.     ||.|. |.....|. ||.  | .. .    .|.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DYKSFLHIHHYNAWPHNNIPGNGSpkFVKQIWQLQSVLRKySPSTPTVYMSLSGCGRAGTFALFETAHLSLHseQATLDLVKCLEMVRNGRIHACQNLTQ
|.. . . ..|  || .. |      . . . .....| . .|. |..     |.||.||...    .  |.  . . | .. . ..|. | ...|.  |
dlerlgiqylylpwpDhgvpdlsi..llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQ

FSFVY
. |.|
yrfly
0051082 (Phosphotyrosine protein) phosphatases II 247-452 2.4e-11 38.9 In-house 3-148 (151) alignment 
Range on Protein: 247-452
Range on HMM: 3-148/151.0
SSYIHASYLEldtqKRAILTQLPLPhtsaDFWQMIIEQRVKCVLLLLTDSEYDslGGDFVFPRNQdflnfeersirvgefkrveimdgwvlkvvsvsngd
|.||..||..     . .... ||.    ||.... |. .|... | .. |..       .|...                                   
sdyinfsyvt....gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

yksflhiHHYNAWPHNNIPGNGSPKFVKQIWQLQSVLRKySPSTPTVYMSLSGCGRAGTFALFETAHLSlhseqatLDLVKCLEMVRNGRIHACQNLTQF
       ...  .|  . |  | | . ... .. ..|..  .. |..    .|.|| ||...    .|        ..| ..||..|  | .. |  .||
.......ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqf

SFVYTL
 |..  
lfqlfa
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 248-457 3.7e-10 32.9 In-house 99-309 (346) alignment 
Range on Protein: 248-457
Range on HMM: 99-309/346.0
SYIHAS---YLELDTQKRAILTQLPLPH---TSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDGWVLKVVS
.|.|     .. .. ... |..|||  .      ||| || ..... | |.. |         ..   |  .       |             . ..|. 
ayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlp

VSNGDYkSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSvlRKYSPSTPTVYMSLSGCGRAGTF--ALFETAHLSLHSEQATLDLVKCLEMVRNGRIha
  | |     ..||.  | | . | .  |  .| | |. |   |   ..    .|| ||||| .|  ||.    |    |   ....| .   | | .  
egnsds.vicqvhhhapwkhlqqppktlp.iikmihqfls..ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggv..

cQNLTQFSFVYTLLAEHI
 . ..|.. .|... ..|
.esfaqyasiyaivfdyi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 259-451 1.3e-06 22.7 In-house 3-198 (199) alignment 
Range on Protein: 259-451
Range on HMM: 3-198/199.0
TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNfEERSIRVGEfKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHY
.|.| | || || .| ||||||. |     ....  |         | .|  .     .  |. |   | .     ... .. ..|      |   | ||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kygslsvtt.ktittkpdytitaliltnnttappstreishy

N--AWPHNNIPgnGSPKFVKQIWQLQSVLRKYSP--STPTVYMSLSGCGRAGTFALFETAHLSL-HSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
.  .|  .  |      ||  .   . | .||     .| .     | | .| |  ..    |   |  . .|| .    .|. |      | .. |.| 
qftswkekttp..nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 259-451 1.4e-06 22.7 In-house 2-197 (198) alignment 
Range on Protein: 259-451
Range on HMM: 2-197/198.0
TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNfEERSIRVGEfKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHY
.|.| | || || .| ||||||. |     ....  |         | .|  .     .  |. |   | .     ... .. ..|      |   | ||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kygslsvtt.ktittkpdytitaliltnnttappstreishy

N--AWPHNNIPgnGSPKFVKQIWQLQSVLRKYSP--STPTVYMSLSGCGRAGTFALFETAHLSL-HSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
.  .|  .  |      ||  .   . | .||     .| .     | | .| |  ..    |   |  . .|| .    .|. |      | .. |.| 
qftswkekttp..nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0049260 (Phosphotyrosine protein) phosphatases II 261-450 3.1e-15 51.6 In-house 9-143 (152) alignment 
Range on Protein: 261-450
Range on HMM: 9-143/152.0
KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFprnqdflnfeersirvgefkrveimdgwvlkvvsvsngdyksflhihhynAWP
...| || |.|.| ||||.|. |. ..... | ...| . |. .. .                                                   . 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................qyl

HNNIPGNGSPKFVKQIWQLQSVLRK--YSPSTPTVYMSLSGCGRAGTFALFETAHlslhseqATLDLVKCLEMVRNGRIHACQNLTQFSFVY
| ..| .| |..   . .|  ...|   ... |..     |.||.||...    .         ..| .....||. | .|..|  |  |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 265-457 1.9e-08 28.7 In-house 39-221 (255) alignment 
Range on Protein: 265-457
Range on HMM: 39-221/255.0
LtqlplphTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDF-LNFEERSIRVGEfkrveIMDGWVLKVVSV--SNGDYKSFLHIHHY--NAW
|       | . |.|.|. .. . | .|    | .    .  || ..|  | ... .. . .      .   ||. . .    |. |    ..||  . |
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGW

PHNNipgngSPKFVKQIWQLQSVLRKyspSTPTVYMSLSGCGRAGTFALFETAHL----SLH-SEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLA
. .|     .|.  ..| ..  | |.   | . | .  .| ||. .|.| | ..     ||. .| . || .. || .|. |  | ..  |..|   .. 
iekn.....aPelareilnilkvvrd...sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

EHI
. .
dlv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 295-458 4e-06 20.4 In-house 38-195 (440) alignment 
Range on Protein: 295-458
Range on HMM: 38-195/440.0
DSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDgwVLkVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRKYSpSTPTVY
 |.  ||  . |  | .. | ..   . . | | |   |   .   |  ||     |. .||..|| . .|   .|  .| | ...    | . . | . 
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsd..yi.nasyingiesrtlkqyhyqgwpdkgvpkfagp.vlkmiqdvnesqekag.ngpllv

MSLSGCGRAGTFALFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 . .|.||.|     ..  |        .|..  .. .|| | .  |   |..||.  . | .|
hcsagagrtgviiavdsi.lreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegll
0048179 (Phosphotyrosine protein) phosphatases II 339-451 8.5e-08 27.6 In-house 33-139 (144) alignment 
Range on Protein: 339-451
Range on HMM: 33-139/144.0
VVSVSNGDYKSFLHIHhYNAWPHNNIPGNGSPKFVKQIWQLQSVLRKY-SPSTPTVYMSLSGCGRAGTFALFETAHlslhseQ-AtLDLVKCLEMVRNGR
|...... .. ||  .    . | ..|..| | . ... ..   .... ... |..     |.||.||...    .          |.| ..|..||. |
vinlteeyepeflere.giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klg.lsleealalvrsrr

IHACQNLTQFSFVYT
 .|..|  |. |.. 
pgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 347-454 1.4e-07 26.8 In-house 41-140 (145) alignment 
Range on Protein: 347-454
Range on HMM: 41-140/145.0
YKSFLHIHHYNawpHNNIPGNGSPKFVKQIWQLQSVLRKYSPS-TPTVYMSLSGCGRAGTFALFETAHLslhseqATLDLVKCLEMVRNGRIHACQNLTQ
.  . .. .|    . ..|..| | . ......   .... ..  |..     |.||.||...    .|        ..| ..||.||. | .|..|  |
ellerlgiqyl...ylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpgq

FSFVYTLLA
. |.| .. 
lrflyefel
PTPc_DSPc_SM00012 352-455 7.9e-20 66.4 In-house 3-105 (105) alignment 
Range on Protein: 352-455
Range on HMM: 3-105/105.0
HIHHYNAWPHNNIPGNGsPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
.  ||..||. ..| ..  .... ....... .| . |.|.| ..  |.||.|||....... .|..|. ..|. ......|. | ...|...|..|.|.
khyhytgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LLAE
 |.|
alle
subfamily_CG42327_pd Subfamily CG42327 391-455 2.6e-06 21.4 In-house 249-313 (319) alignment 
Range on Protein: 391-455
Range on HMM: 249-313/319.0
PTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
| |     | ||.|.    . |  ||   . ..|. . .  ||..| .| ..  |. |.|  | |
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse