Synonym: CELE_F40G12.10, F40G12.10
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| 0050432 | (Phosphotyrosine protein) phosphatases II | 115-404 | 3.6e-41 | 136.9 | In-house | 18-303 (308) | alignment | ||
Range on Protein: 115-404
Range on HMM: 18-303/308.0
SGNVKNVEKGVKVWIELLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGgGEADFFYHGSTLTIPS-VTTKSTILAQLA
| .|.. . |. ...||||..... .| ||. . .| .|| .. ....|.|. .. .. || .||| .| . ... | ...| .. |..|
silvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgP
IvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE----DFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDA
|...|.|| || |... | ..| .... .|.|. ...|.. ..|..... .. |. ..|...... | . .. . |||
l...pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhytnWpdh
KIPT--MGYNRIAATAASVFesdidCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHV
..|. . .. . ... . ... .. | ||.| | .. |..| |... ... |. .|.||| ...|..||.| | ..| | ....
gvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
|
|||||||||
| subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 120-416 | 1e-118 | 390.2 | In-house | 2-301 (302) | alignment | ||
Range on Protein: 120-416
Range on HMM: 2-301/302.0
NVEKGVKVWIELLEKMDFRKT-----MEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTtKSTILAQLAIV
.||.... |.| |.... |. ...|||.|||||.|||||.|||||....|||.|...|.|.||...|.|.....|....|..| .|.|||||..|
kveeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkv
DSPQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP---EDFKEFKTIRVNNRKtVPKTEEQAnTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP
||..|.|.|| ||...||....||.|||||.| ||||.|| .|.||.....||||| |.|.||.. |....||.|..|.....|.......|...|.|
dsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp
tMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKDPALKI
. |.....|||.||...|..|....|||..||||||.|.....|.||||.|..||||||. |.|||||.|...|.||...|...|.|..|.|..|. |
.vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekk
KTEKV
|.|.|
kkeev
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 122-403 | 3.1e-38 | 127.3 | In-house | 15-292 (297) | alignment | ||
Range on Protein: 122-403
Range on HMM: 15-292/297.0
EKGVKVWIELLEKMDFRKTMEPEFKPIDTMKADlEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADF-----FYHGSTLTIPSVTTKSTILAQLAivdS
.|. .. ||||.... ... ||. . .| | .. ....|.|. .. .. || .||| .| .. ... | .. ....|. |..| .
plsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP...l
PQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFPEDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAeaPFAMIEICDFWPDAKIP--TMG
|...|.|| || |... . | ..||.. . .|.||. ......|...|. .. |. . ||..... . . . ||| ..| .
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkveh...ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslel
YNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
.. . ...... . . ... .. | ||.|.| .| |..| |. . ....|. .|.||| |..|.|||.| | ..| . ...
lleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
|
|||||||||
| 0051299 | (Phosphotyrosine protein) phosphatases II | 122-399 | 1e-34 | 115.8 | In-house | 8-285 (288) | alignment | ||
Range on Protein: 122-399
Range on HMM: 8-285/288.0
EKGVKVWIELLekMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAIvds
|. .|.. .|| ... .... ||. . ...||. .. ....|.. .. .. || .||| .| | . ... | .... . | |..|
eellklvlkll..angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl...
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPK----DCAEAPFAMIEICDFWPDAKIP
|...|.|| || |... .| ...||.. . |.| ....... |.|...... .. |. . ||... . | . .. . ||| .|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp
TmGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . . . | .. ... ... .. | ||.| | .. |..| |.... ... |. .|.||| ...|..||.| | ..| |
d.spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 124-432 | 1.9e-41 | 137.7 | In-house | 4-308 (317) | alignment | ||
Range on Protein: 124-432
Range on HMM: 4-308/317.0
GVKVWIELLEKMDFrKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQS
... ....| |.|| . .. ||. ....| | .. ....|.|. .. .. .|| .||| || . . ... | ..|. ..| |..| |..
dlllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPl...pnt
LESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYN
.|.|| || |... . | .|||.... .|.| ..........|...... .. | . ||..... | . .. . .||| ..| .
vedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdlll
RIAATAASVFEsdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKDPALKIKTEKV
.. . ...| | . ... .. | ||.|.| .| |..| |. .. ....|. .|.||| |..|..||.| | ..| | ....... .. . |.
dfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl
ISQLEQFACEKMTEED
. .|. .|........
lklliplalddvklke
|
|||||||||
| subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 125-406 | 3.5e-13 | 44.2 | In-house | 3-283 (307) | alignment | ||
Range on Protein: 125-406
Range on HMM: 3-283/307.0
VKVWIELLEKMDFRKtMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRV--KGGGEADFFYHGSTLTIpSVTTKSTILAQLAIvDSpqSLES
|| |.. .. .. . ||. . .. . .||. | | . ..|. | .|. | | | . | | | .. | | || .. . |
vkpwvqrtldkgvqa.lvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgi.aikpkkficaqgpl.en..tqys
FWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-------KEFKTIRVNNR--KTVPKTEEQANTqLYYEVVPKDCAEApFAMIeICDFWPDAKIPTM
|| |. .|.. . .| || | .|.| . .. .|| |.| |.. |. | .|. . . . . . ||| .| .
fwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkvdwaqksrt.iqhl.qwenwpdrgvpqi
GYNRIAATAASVFEsdidcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKD
. | | .. . | ||.|. | .|. ||. ..|.. .||||. ||.| ||.. . . | | |. |.
nltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
|
|||||||||
| 0045450 | (Phosphotyrosine protein) phosphatases II | 126-400 | 4e-37 | 124.0 | In-house | 14-304 (307) | alignment | ||
Range on Protein: 126-400
Range on HMM: 14-304/307.0
KVWIELLEKMDFRKTMEPEFKPIDTMKADLE---KCQAFKKNIDFSQSENVELYDTNRVKGGG-----EADFFYHGSTLTIPSV-------TTKSTILAQ
... ||.. ||. .. ||. . .. .| .. ....|.|. .. .. .|| .||| | . ....| ..|.. .. |..|
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq
LAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDfKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPK-DCAEAPFAMIEICDFWPDAK
|...|.|| |. |... . | ...||... .|.|.. .|..|.. ... ..... | ...|| .. . | . .. .. ||| .
gPl...petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg
IP--TMGYNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEA---PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
.| . .. . ...|.. ... ... .. | ||.|.| .| |... |.... ... |. .|.||| |.....||.| | ..| .
vppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
|
|||||||||
| 0047943 | (Phosphotyrosine protein) phosphatases II | 129-399 | 2.3e-36 | 121.1 | In-house | 2-271 (273) | alignment | ||
Range on Protein: 129-399
Range on HMM: 2-271/273.0
IELLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQSLESFWIMV
. ||||........ ||. . .| .|. .. ....|.|. .. .. || .||| |.. . ... | .. . .. | |..| |...|.|| ||
llllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk.fiatqgPl...pntvedfwrmv
ASQKIQRLFILLGEEELDKPTLSEYFPED----FKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAAT
|... . | ..||.... |.|.. ..... ..|..... .. |. |...... | . .. . ||| ..| . ..
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel
AASVFESDIDCdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. ...|.... .. .. | ||.|.| .. |... |... ....|. .||||| ...|..||.| | ..| |
vrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
|
|||||||||
| subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 130-402 | 9.6e-13 | 42.5 | In-house | 15-289 (305) | alignment | ||
Range on Protein: 130-402
Range on HMM: 15-289/305.0
ELLEKMDfrKTMEPEFKPIDTMkADLEKCQAFKKNIDFSQ--SENVELYDTNRVKGGGEADFF-YHGSTLTIPSvTTKSTILAQLAIvDspQSLESFWIM
. |||. . . ||. . . |.|| .|||. . . .| | |||| | | .. |. .| | .| . . .. || |
rtlekgp..aglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstpt.npkrfictqapl.e..ktcadfwym
VASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKD-----CAEAPFAMIEIC-----DFWPDAKIPTMGYn
.|.. .|.| | .|||. . |. ... ...| . | | .. .. . | | | . . ||| .|.
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl.
riaaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAP-NIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLK
. ..| .. | ||.|| . ...| ||. . . | .| || .|.| ||.| . . | | .|
....ailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
|
|||||||||
| 0036941 | (Phosphotyrosine protein) phosphatases II | 131-403 | 1e-41 | 138.5 | In-house | 5-280 (297) | alignment | ||
Range on Protein: 131-403
Range on HMM: 5-280/297.0
LLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQSLESFWIMVAS
||||..|. .. ||. .. .... . .......|.. .. .. || .||| ..| . ....| ....... | |..| |...|.|| ||
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk.fIatqgPl...pntvedFWrmvwe
QKIQRLFILLGEEELDKPTLSEYFP---EDFKEFKTIRVNNRKTVPKtEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPT--MGYNRIAATAAS
|... . | ..||.... .|.| ....... ..|..... . ... |. . ||..... | . .. . ||| ..|. . .. . .
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk
VFeSDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ---AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
| . . . . .. | ||.|.| .| |... |. . ..|.|. ...|.||| |..||.||.| | . | . .|.
vl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
|
|||||||||
| subfamily_PTPN13_pd | Subfamily PTPN13 | 131-398 | 3.9e-18 | 60.7 | In-house | 4-267 (273) | alignment | ||
Range on Protein: 131-398
Range on HMM: 4-267/273.0
LLEKMDFRkTMEPEFKPIDTMKADlEKCQAFKK--NIDFSQSENVELYDTNRVKGGGEADfFYHGSTLTIPSvtTKSTILAQLAIVDSPQSLESFWIMVA
| .|.| . . ||| . .|. ..|. || | | . || || ||| |.|. . | . .| | . . .. |.. . || ||
lqkkldqq.qPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvw
SQKIQRLFILLGEEELDKPTLSEYFPEDFKefKTIRVNNRKTVPKTEEQANTQLY-YEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIAAtAASV
|| . . .. | | .| |.|| . |.. |.|| .| . . | .. .. || . . . .| ||| ..|. . . .| |
eqkaeviamvtlekekgkvkchrywPeskn..kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqf.vaev
feSDIDCD-ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
.. | . .. | ||.|.. . ... .. . ..||| ..| || . . | ||.| | ..|.
..rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 134-399 | 1.1e-39 | 132.0 | In-house | 15-276 (278) | alignment | ||
Range on Protein: 134-399
Range on HMM: 15-276/278.0
KMDFRKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAivdSPQSLESFWIMVAS
......... ||. ....| | .. ....|.|. .. .. .|| .||| || . . ... |... ..|..| |..| .|...| || ||
llnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgP...lpetvedFwrmvwe
QKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFE
.... . | ...||.... .|.|..........|...|. .. |. ||... . | . .. . ||| ..| . . .. .. ...|
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh...lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale
sdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
|.. .. .. | ||.| | .. |..| |. . ... |. .|.||| |..|.|||.| | ..| |
...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
|
|||||||||
| subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 137-397 | 1.6e-13 | 45.4 | In-house | 19-276 (288) | alignment | ||
Range on Protein: 137-397
Range on HMM: 19-276/288.0
FRKTMEPEFKPIDTMKADLEKCQAF-KKNIDFSQSENVELYDTNRVKGGG---EADFFYHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKI
|. .. |.. . ... . ..... .| . . .|. || .||| . ||. | .. . .| | .| . ..... || .| .|.
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl...adtvndfWelvyenkt
QRLFILLGEEELDKPTLSEYFPEDFK--EFKTIRVNNRKTvPKTEEQANTQLYYEvvpKDCAEAPFAMIEIcDFWPDAKIPTMGYNRIAATAASVFESDI
. . | . | .| . ||.|.. | .. . | ... ..|. . .| | |. | . ||| ..| . .. ..
stivmltelveggktkCeeYWPdadkpknyGsvtvtlves.keledfvlrkllle...kkkteleitqyqy.laWpdhgvPeskapllellrqvkvanqa
DcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
| .. | ||.| | .. .|..... . .. .. .| ||. ..||.||.| | . |
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
|
|||||||||
| subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 137-399 | 8.6e-08 | 26.2 | In-house | 17-275 (312) | alignment | ||
Range on Protein: 137-399
Range on HMM: 17-275/312.0
FRKTMEPEFKPIDTMKADLEkCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIpsvTTKST--ILAQLAIVdspQSLESFWIMVASQKIQR
. . |.| . . .| | | || | |. . |.. .| | |. .|. | . | || . .| .. .. || .. |
tpqqltkeykavgnivsdse.ctaflkfkdlnrypniqcwdrgrftlagdenfyihanfvki...ctkperfvctqgple...ntcthfwqlalslgsts
LFILLGEEELDKPTLSEYFPE--DFKEFKTIRVNNRKT-----VPKTEEQANTQLYYEVVPKDCAEAPFAMIEIcDFWPDAKIPTMgynriAATAASVFe
. .| | | ..| . | ... || |. .. .. || |. . . ||| .| || ..
iillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqw.aswpdhgmpds.....cdtalrll.
SDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . | | | ||.|.. . | |. |.|.. . .| .| ..... ||... . | .
savkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
|
|||||||||
| subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 138-399 | 1.4e-12 | 42.3 | In-house | 22-282 (319) | alignment | ||
Range on Protein: 138-399
Range on HMM: 22-282/319.0
RKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVKGG---GEADFFYHGSTlTIPSVTTKSTILAQLAIVDspQSLESFWIMVASQKIQR
...| ||| ... ..| . ..| . . .|. || ||. | . | .. | . .. .| | .. . .| || || ...
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinas.fidgyqerekfiatqaPle..ntiedfWrmvWeeessi
LFILLGEEELDKPTLSEYFPEDF-KEFKTIRVNNRKtVPKTEEQANTQLYYEVVPKDCAEapfAMIEICDF--WPDAKIPTMGYNRIaATAASVFESDID
. .| . | | |..|.|| .|. . |. . ..|. .| . . .. . ||| ..|. . . . . .|
vvmltklveklkvklkkywpeenfeeyGrlivtlee.eeeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekatsll.dllkrirksrek
CDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.. .| |.|| |.| | ..|... .. .. ... .| ||. ... .|| | | . | .
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
|
|||||||||
| subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 139-394 | 7.8e-12 | 40.0 | In-house | 22-277 (305) | alignment | ||
Range on Protein: 139-394
Range on HMM: 22-277/305.0
KTMEPEFKPIDTMkADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFF---YHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRL
|..| ..| . . . . . ..| ...... |.|..|.. . . | .. |. |.|| . .. .. || .. |.. .
kgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPl...kntvadfWrliveekvsti
FILLGEEELDKPTLSEYFPEDFKE---FKTIRV--NNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDfWPDAKIPTMGYNRIAATAASVFESDI
.| . | .| |.|| .| | . | ...||.. . . .| . .| . .. | ||| .|.. . .
vmltklveggkdkCrqYWpesktekkefgefsvelksektas...dyieRklkisiededkesrtvlqyqltd.WPdhGvpqfatsllslikrvqkdqkk
DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYV
| . . .. . | ||.| | . .|.|.|.. | .. |. .||.|. ...|| ||.| .
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
|
|||||||||
| subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 139-401 | 6.1e-08 | 26.6 | In-house | 35-284 (290) | alignment | ||
Range on Protein: 139-401
Range on HMM: 35-284/290.0
KTMEPeFKPIDTMKADL-EKCQAFKKNidfsQSENVELYDTNRV--KGGGEADFFyHGSTLtipSVTTKSTILAQLAIVDSpqsLESFWIMVASQKIQRL
... | . | . .. .. .| |||| . .| | || | |.. |. | . . ||.| |. |. .| || .|. .
eklkp.ylpvqylerkifdkntefkkn....rykdvvcndktrvilkdGydGdyv.hanyv...kGlkamfiltqGalkdt...vidiwrmvlqekvaai
FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYY-EVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNrIAATAASVFESdidcDA
.| | |. ..|.|| | |. .....||... | || ||| .. . | .. .
vmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla.llrtlrilrka....sG
SCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGL
.. | ||.|.| ... | | . .. .. ..| | .... ||. | | .|
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
|
|||||||||
| 0046845 | (Phosphotyrosine protein) phosphatases II | 141-403 | 1.5e-32 | 108.5 | In-house | 2-277 (284) | alignment | ||
Range on Protein: 141-403
Range on HMM: 2-277/284.0
MEPEFKPIDTMKADLE---KCQAFKKNIDFSQSENVELYDTNRVKGGG-----EADFFYHGSTLTIPS----VTTKSTILAQLAIvdsPQSLESFWIMVA
.| ||. . .. .|. .. ....|.. .. .. || .||| | . ... | .. .. ..| |..| |...|.|| ||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl...pntvedFwrmvw
SQKIQRLFILLGEEELDKPTLSEYFP--EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKD-CAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAA
|... . | ...| .. . |.| ....... ..|..... .. |. |..... . | . .. . ||| ..| . .. ..
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr
SVFESdIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGE---APNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
...|. .... .. . | ||.| | .. |..| |.... ... |. .|.||| ...||.||.| | ..| | ...
ellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
|
|||||||||
| subfamily_Ptp69D_pd | Subfamily Ptp69D | 141-403 | 4.1e-15 | 50.7 | In-house | 24-289 (307) | alignment | ||
Range on Protein: 141-403
Range on HMM: 24-289/307.0
MEPEFKPIDTMKADLEKCQ-AFKKNIDFSQSENVELYDTNRVKG---GGEADFFYHGSTLTIPSVTTKSTILAQLAIvDSpqSLESFWIMVASQKIQRLF
.. |.. . . . |.. . | | ..|.. .| .||| |..| | . . .|. | || . .. .. || |.| |... .
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv.ea..tigDfWRmiaeqevtliv
ILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTvPKTEEQANTQLYYEVVPKDCAEAPfAMIEICDF----WPDAKIPTMGYNrIAATAASVFESDID
.| ..| .. . |.| || ... | |. .. |... .. .|.. . .. .| . . .. . |.| |.| . . | |
mlsnlteknrkkcakYWpiedevqygdilvklvse.ekhsdyiiReldvskkkeesgeve.dsrkvvqyhytgWkDskvPevarg.llklieqvrelykl
CDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
. . . |.||.| | . ...|.| . .| |. .||||. .. | ||.| | | | .
nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
|
|||||||||
| subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 141-399 | 5e-15 | 50.4 | In-house | 22-279 (318) | alignment | ||
Range on Protein: 141-399
Range on HMM: 22-279/318.0
MEPEFKPIDTMKADLEKCQAFKK-NIDFSQSENVELYDTNRVKGG---GEADFFYHGSTLtIPSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLF
.. |.. .. .. . .. .. | . |. ||. ||| || . | . |. . | . .| | . |. .| || || |. . .
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinany.idGyrrkkayiaaqaPl..petieDfWrmvWeqnsaviv
ILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTVPKTEeqaNTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAAtAASVFESDIDCDAS
.| ||| | . |.|.. .......|. ...| .. . ..| ... | . ||| .|. | . .. .| . . ...|.
mltqeeergkakvhryWPskgsrsygklvvelkeevelsd...yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl.vrqvskaqqksgag
CAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. .| | ||.| | . .|...| . .. .. .|.||.. . | .|| | | . | .
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
|
|||||||||
| subfamily_PTPN14_pd | Subfamily PTPN14 | 141-399 | 1.3e-14 | 48.9 | In-house | 25-295 (300) | alignment | ||
Range on Protein: 141-399
Range on HMM: 25-295/300.0
MEPEFKPIDTMKADL-EKCQAFKKNIDFSQSENVELYDTNRVKGGGEAD--F-FYHGSTLTIPSVTTK-STILAQLAIvdsPQSLESFWIMVASQKIQRL
. .|. | ...| .. . ..| . .. ..| |. |||. . . |.. .. ... | | || . .. .. || || |..| .
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqli
FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRK----TVPKTEEQANTQLYYEVVPKDcAEAPFAMIEICDfWPDAKIPT-----MGYNRIAATAASVF
.| ||| | .|||.. .. ||.. .. | . ... . |.| . .| | .. | ||| ..| . | . .
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytD.WpdhgvPeDvkgflsyLeevqsvrrkt
ESDID---CDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.| .. . . |.||.| .. | |. |. .| .||.. .| || ..||.|| | | . ..|
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
|
|||||||||
| subfamily_PTPN1_pd | Subfamily PTPN1 | 141-412 | 5.1e-12 | 40.1 | In-house | 8-282 (290) | alignment | ||
Range on Protein: 141-412
Range on HMM: 8-282/290.0
MEPEFKPIDTMKADLEKCQA-FKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVtTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILL
.. .. |. |.. .| ...| . . .|. || |.| . . | . .. . .| ||.| . |. . || || || . . .|
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleea.krsyiltqGPl...pntvdhfWqmvWeqkskavvmln
GEEELDKPTLSEYFPEDFK--EFKTIRVNNR-KTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNrIAATAASVFESDI-DCDAS
| .. .|.|.. . |.. .. . | . . ... | .|. . . |. . ||| .| . | || |
kvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa.flkflfkvresGslssdvG
CAIV-SNYGAGRAGSFFVA---VLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYViALTYGLKHVKDPALKIK
|.. | ||.|.| .. .. ||| . .. .||. | .|..| | | | |.|. |. | | .|... |
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl.aileGakvikgdssvqk
|
|||||||||
| subfamily_PTPRB_pd | Subfamily PTPRB | 141-393 | 9.2e-10 | 33.0 | In-house | 27-278 (293) | alignment | ||
Range on Protein: 141-393
Range on HMM: 27-278/293.0
MEPEFKPIDTMKADLEKCQA-FKKNIDFSQSENVELYDTNRVKG---GGEADFFYHGSTLtIPSVTT-KSTILAQLAIvdsPQSLESFWIMVASQKIQRL
. |.. . ... | .. .| ..| . . .|. ||..||| .|.. | . || .. . | .| . |.... || || .| . .
fseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany.ipgynsprefiatqGPl...petvddfWrmvwekkssii
FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEAPFAMIEIcDFWPDAKIPTMGYNRIAATAASVFESDIDCDAS
.| | | ||.|.| .. .. . ..||. . . . |. .| . ||| .| . .. . . . . .....
vmltqlvekgkvkCeeYWPadeepvlyGdikvt..lvaeeeledwvirelkiekekeerkvrqyhf.tsWpdhgvPektktlldfvrtvreaiektaskr
CAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTY
.| | ||.| | ..... . .| | ..|..| . | .||.| .
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifih
|
|||||||||
| DSPc_SM00195 | 144-399 | 2.3e-33 | 111.0 | In-house | 5-261 (263) | alignment | |||
Range on Protein: 144-399
Range on HMM: 5-261/263.0
EFKPIDTMKAD-LEKCQAFKKNIDFSQSENVELYDTNRVKGGGE----ADFFYHGSTLTIPsVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFIL
||. ..... . .....||| . ...|. .|| .||| | . ... . .... .|. |..| |. .|.|| || .|.. .|
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivml
LGEEELDKPTLSEYFPED---FKEFKTIRVNNRKTVPKTEEQANTQLyyEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDidcD
||| .| . ..|.||. ..|..|.|..... | .| ..| |. ... |. .. . ||| ..| |. .. .. . .. .
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...s
ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . ... | ||.|.| .. ....||.... ..|.|| ..|.||| ...|| ||.| | ..| |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
|
|||||||||
| PTPc_SM00194 | 144-399 | 2.3e-33 | 111.0 | In-house | 5-261 (263) | alignment | |||
Range on Protein: 144-399
Range on HMM: 5-261/263.0
EFKPIDTMKAD-LEKCQAFKKNIDFSQSENVELYDTNRVKGGGE----ADFFYHGSTLTIPsVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFIL
||. ..... . .....||| . ...|. .|| .||| | . ... . .... .|. |..| |. .|.|| || .|.. .|
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivml
LGEEELDKPTLSEYFPED---FKEFKTIRVNNRKTVPKTEEQANTQLyyEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDidcD
||| .| . ..|.||. ..|..|.|..... | .| ..| |. ... |. .. . ||| ..| |. .. .. . .. .
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...s
ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . ... | ||.|.| .. ....||.... ..|.|| ..|.||| ...|| ||.| | ..| |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
|
|||||||||
| subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 152-399 | 1.4e-13 | 45.5 | In-house | 31-270 (288) | alignment | ||
Range on Protein: 152-399
Range on HMM: 31-270/288.0
KADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTipSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSE
.| . ..| .| . ||. |. ||| ..||. . .. | | .. | . .| .| |. .. .. . .| |. |. |
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs..sakykrrlicaqaPl..ngtieelWkmllesdveyivmlcellekGkeksae
YFPEDFKEFKTIRVNNRKTVPKTeEQANTQLYYEVVP--KDCAEAPFAMIEICDFWPDAKIPTM--GYNRIAataaSVFesdIDCDASCAIVSNYGAGRA
||| | |. . . | .. . . .. | |. . | |.| .| . |. |. ... . |. |.||.
yfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll....evl...kslqkPivvhssaGvGrt
GSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . . ..|.| |. . |... . | .| ||.| ||.. . . | .
gtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
|
|||||||||
| subfamily_PTPN23_pd | Subfamily PTPN23 | 156-399 | 1.5e-15 | 51.7 | In-house | 35-279 (288) | alignment | ||
Range on Protein: 156-399
Range on HMM: 35-279/288.0
EKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE
. . |.. . .|... || |||| |. | . | . | .. . | .| ...| || || .|| . . .|| .|||.|| ..|.||
rsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaP...lqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe
DF---KEFKTIRVNNrKTVPKTEEQANTQLYYEVVPKDCAEAPFAMieICDFWPDAKIPTM--GYNRIAATAAS-VFESDIDCDASCAIVSNYGAGRAGS
| ..|. ..| | | .||. . .| |. ..| . . ||. .| . .. . | . ... . | ||.|
dkgetvkfgdlsvtl.ksvretethvervlkletldadavksvshl..qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv
FFVAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . . |...|..|. ..| .. .| || ... .|. |.| . |..
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 157-399 | 2e-31 | 104.7 | In-house | 2-242 (245) | alignment | ||
Range on Protein: 157-399
Range on HMM: 2-242/245.0
KCQAFKKNIDFSQSENVELYDTNRVKGGGEA----DFFYHGSTLTIPSVTTKsTILAQLAIVDspqSLESFWIMVASQKIQRLFILLGEEELDKPTLSEY
.......|.|. ..... .|| .||| . . ... | . . .| | |..| . ..| || |. ...|. .. | ||||.... .|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqy
FP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESdiDCDASCAIVSNYGAGRAGS
.| ..........|..... .. |. ..||... . | . . . ||| ..| . .. . .. .. | . ... .. | ||.|
wplgesltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGt
FFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| .| |..| |.. .. |. .||||| |..|.|||.| | ..| .
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
|
|||||||||
| subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 157-398 | 7.1e-09 | 30.0 | In-house | 26-264 (283) | alignment | ||
Range on Protein: 157-398
Range on HMM: 26-264/283.0
KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPS--VTTKSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP
.... ..| . . ... .| .||. |. . . ... | | || . . || || .|| . .| | . | |.|
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld...rtvvdfWkmvfdekitaivmltklqedlrikCsqyWP
E----DFKEFkTIRVNNRKTVPKTEEQANTqLYYE-VVPKDCAEAPFAMIEICDFWPDAKIPTM-GYNRIAATAASVFESDIDCDASCaivsnyGAGRAG
. |. || |. ... | . . | .. . | . .|. .. ..| | .. .|.. . .. | | | ||..
krGsedyGef.tvtlrkettsnsfiikell.lrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCst......giGrta
SFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
| |. ....... .. .. .| ||. |. || ||.. . ..|
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 158-400 | 1.6e-29 | 98.7 | In-house | 5-246 (249) | alignment | ||
Range on Protein: 158-400
Range on HMM: 5-246/249.0
CQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYF
. ...|.| .. .. || .||| .|.. . ... | .. . .... |..| |...|.|| |. ..|. . | ..||.. . .|.
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgP...lpetvedfwrmlwelgitvivmLtslvelgrekcaqyw
P-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSF
| ....|.....|..... .. |. . |.... . | . . ||| ..| . .. . ...|.. ... ... .. | ||.| |
plggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtf
FVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
.| |..| |. ...|. .||||| |.....||.| | ..| .
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
|
|||||||||
| subfamily_CG7180_pd | Subfamily CG7180 | 158-401 | 6.2e-11 | 36.5 | In-house | 36-291 (296) | alignment | ||
Range on Protein: 158-401
Range on HMM: 36-291/296.0
CQAFKKNIDFSQSENVELYDTNRV---KGGGEADFFYHGSTLtIPSVTTKSTILAQLAIVDspQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP
.. |.|.. . .| || ||| | .||.. | .. . | . | . | .. .....|| .| ..|. . .| . . | .|.|
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavy.vdsflkkkeyivteapkk..etvdefWrlvydeeisavvvLtktfdfak.mypsywp
ED-FKEFKTIRVN--NRKTVPKTEeQANTQLYYEVVPKDC----AEAPFAMIEIC--DFWPD-AKIPTM--GYNRIAATAASVFESD--IDCDASCAIVS
.. .... | |. . |. .. . . . .|. ..| .|. .. |. |.| .. . . .. | . . .||
nkskeqygeifveiveekqyanlk.irtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs
NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGL
. ||.|.| .. . ..|... | .. | . .| .|| .|. .|.. | . | . |
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 159-397 | 1.3e-25 | 85.8 | In-house | 5-239 (243) | alignment | ||
Range on Protein: 159-397
Range on HMM: 5-239/243.0
QAFKKNIDFSQSENVELYDTNRVKGGGeaDFFYHGSTLTIPsvttKSTILAQLAIVDSPQS-LESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF
.. |.. . .. .|| .||| .| . ..... ... . |. |. .. .. |.||| |. ...|. . | ..||.. .|.|...
allpenlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev
kEFKTIRVNNRKTVPKTEeqaNTQLYYEVVPKDCAEAPFAMIEICDF-WPDAKIPT--MGYNRIAATAASVFES-----DIDCDASCAIVSNYGAGRAGS
......|.. .. . . |. .......|. . .. | .. . ||| ..|. .. . .. |. .| . ... | ||.|
.tygdftvtllseehldd...ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt
FFVAVLAIEKLqagEaPNIKEIALSVRSQRPA-AIETLSQYMFTYVIAL
. .| | ...| . .. |. .|.||| |..|.|||.| | ..|
liaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
|
|||||||||
| subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 159-396 | 1.3e-11 | 38.7 | In-house | 42-275 (303) | alignment | ||
Range on Protein: 159-396
Range on HMM: 42-275/303.0
QAFKKNIDFSQSENVELYDTNRVKGGGEAdfFYHGSTLTIPsvTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE--D
. | ||.| . .| | .|| . . | | | . ..| .||.|| . ... || |. ||.. ...|| . | || ||. |
nqfvknmdknrfvdvicldhskvklsdss..yihasyleld..sskkailtqlpl...shtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd
FKEF--KTIRVNNRKTVPKTEEqanTQLYYeVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAAT---AASVFESDIDCDaSCAIVSNYGAGRAGSFF
| .| ..||| . | | .. .| . . | . . || ..||. | .. ||. |. .| | ||||.|
flkfeersirvgefkrvelgdg...wvlkv.lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfa
VAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIA
. | |.. .| .. || | |.. |||. . | .
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
|
|||||||||
| subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 159-400 | 5e-09 | 30.5 | In-house | 30-270 (285) | alignment | ||
Range on Protein: 159-400
Range on HMM: 30-270/285.0
QAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK
|.. | |. . .| . || . | | . .| . | .| . |..| || |. .|| ...| | . |.|| .
tayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl...petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg
EFK-TIRVNNRKTVPKTEEQANTQLYYEVV--PKDCAEAPFAMIEI-CDFWPDAKIPTMGYNRIAAtAASVFESDIDCDASCAIVSnYGAGRAGSFFVAV
| . . | | | | | | | .|.. |. | . .||| | | | . . | .| | ||. .|
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.ykwvkkvnpkekpicvhcs.agvgrtatfvgid
LAieKLQAGEAPNIK--EIALSVRSQRPAAIETLSQYMFTYVIALTYG
| .. | |||. .| .|. | |... |..| ||. . |
ya..tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 160-401 | 3.5e-20 | 68.0 | In-house | 29-273 (278) | alignment | ||
Range on Protein: 160-401
Range on HMM: 29-273/278.0
AFKKNIDFSQSENVELYDTNRVKgggeaDfFYHGSTLTIPsvtTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-K
. .|.|. .. || .||| | . . | .... .| |..| |. ...|| |. ...|. . | ...||.. .|.||. .
lylgnldknRykdilpydhsrVk.....d.YINAsyidgy...pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl
EFKTIRVNNRKTVPKtEEQANTQLYYEVVPKDCAEAPFAMIEICD--FWPDAKIPTMGYNRIAATAASVFESDID--------------CDASCAIVSNY
... ..|.. .. .. . |... . .. . . ... . .||| .|.. . . . .. .. . ... ..
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa
GAGRAGSFFVAVLAIEKLqaGEAPNIKEIALSVRSQRPA-AIETLSQYMFTYVIALTYGL
| ||.| . .| | .| | .. .. |. .||||| |...|.||.| | .| . |
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
|
|||||||||
| subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 160-399 | 1.2e-16 | 55.6 | In-house | 37-275 (281) | alignment | ||
Range on Protein: 160-399
Range on HMM: 37-275/281.0
AFKKNIDFSQSENVELYDTNRVKGG---GEADFFYHgSTLTIPSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED
..|. . |. || ||| . . | .|... . .| . | |.||..|| || .||.. . .. | | .| |.|.|
kadenvlknrYsnivaYDatrvkvtpneenkntDYi.nanfvpgykgekeyiatqgPv..PaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd
FKEFKTIRVNNRkTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICdFWPDAKIPTMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLA
.| | | . .. ..|.. . ... ... . . .. ||| .|. . . .. .. . .|. | | ||.|.. .
nselkygdvtvk.staeeekatyierkfkleresgetreveqlayt.aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl
IEKLQ-AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
..... | ..|.. ..| .| . |. || | | . | .
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
|
|||||||||
| subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 160-395 | 7.9e-07 | 23.5 | In-house | 44-283 (325) | alignment | ||
Range on Protein: 160-395
Range on HMM: 44-283/325.0
AFKKNIDFSQSENVELYDTNRV-----KGGGEADFfYHGStlTIPSVTTKSTILAqlAIVDSPQSLESFWIMVASQKiQRLFILLGEEELDKPTLSEYFP
. .|.. . .|| .| .|| | ...|. . | . . | . || | . ..... .| .| . . ..| | .|.| . |.|
mkpenkaknrfknvvaldksrvvletkkddpssdy.inas..ylrddkkkdvfla..aqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywp
ED---FKEFKTIRVNNRkTVPKTEEQANTQLYYEVVPKdcAEAPFAMIEICDFWPDA---KIPTMgYNRIAATAASVFESDID-CDASCAIV--SNYGAG
.. |.| ...|. | |. . . .| | | |. |.| | |. | . | | . || |. | |
kemgksktfGglevklr.tieeisdyvhrvldvkqvkk..GetrsvkqfqlqswddmGvqkrpat.lisilqlvkavservtantkastpilvhcsaGvG
RAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
|.| | |..|. .| . .| .||. .|| ||.. |
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea
|
|||||||||
| subfamily_PTPN3_pd | Subfamily PTPN3 | 162-392 | 1.7e-11 | 38.5 | In-house | 39-267 (280) | alignment | ||
Range on Protein: 162-392
Range on HMM: 39-267/280.0
KKNIDFSQSENVELYDTNRVKGGGEA-DFFYHG-STLTIPSVTTK-STILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK
.|.. . .. ||. ||| . |. . ||| .. | .| . ... . || || ||.. . .| | . .|.|| .
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPl...aktatdfWqmvweqksslivmlttlverGrvkChqyWPeted
EFKTIrvnNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIaATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLA
|.. . . . . |.. .. .. |.| || .. .| . ||| ..|. . . .| . . . | ||.| . . .|
eleyg...efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadfl.efvervrklrsgkeePvvvhCsaGigrtGvlilleta
IEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFT
. ...| |. .. .| .| || . ..| ||| |
lalieaaepvypldivrtmrdqramlvqtasqykfv
|
|||||||||
| subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 162-399 | 3.8e-08 | 27.8 | In-house | 47-283 (297) | alignment | ||
Range on Protein: 162-399
Range on HMM: 47-283/297.0
KKNIDFS--QSENVELYDTNRVKGGG-----EADFFYhGStlTIPSVTTkSTILAQlaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP
.|...|. . .|. ||..||| ..|.. | .... | | ..... || || .... . .| ..| || |..
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvn.as..fvkgnkh.rlittq...mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs
ED-FKEFKTIRVNNRkTVPKTEEQANTQLyyEVVPKDCAEApfAMIEICDF--WPDAKIPTMGYNRIAATAASVFESDIDCDAS-CAIV-SNYGAGRAGS
.. ..| .. | .| . | . .| || . ... .| ||| ... . | . | . |. .| | ||.|
dkgvttfGdvsvvll.svsereGfikrel..evtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv
FFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . . . .. .| .. .| .|| . | || | ||. | .
lltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
|
|||||||||
| subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 163-406 | 9.6e-11 | 35.9 | In-house | 54-295 (305) | alignment | ||
Range on Protein: 163-406
Range on HMM: 54-295/305.0
KNIDFSQSENVELYDTNRVKGGGEAD-FFYHGSTLTIPSVTTKSTILAQLAIvDspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFK
.| . ..| | . || . . | . | . | | || . | |... || || .|.... .| || | ..|.| | .
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpl.d..qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl
TIR----VNNRKTVPKTEEQANTQLYYEVVPK-DCAEAPFAMIEICDfWPDAKIPTMGYNRIAATAAsVFESDIDCDASCAIvsnyGAGRAGSFFVAVLA
... |.| | .|. |. . . .. .. ||| .| . .| . | . |. | ||.|.
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwte.wpdrgvppckltslellsa.irgskvpivvhcsa....gigrtgtivaieyi
IEKLQ-AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKD
.||. ..| . |. ..| || .|.. ||.| . . | | |.. |.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 164-399 | 1.1e-10 | 36.9 | In-house | 1-170 (182) | alignment | ||
Range on Protein: 164-399
Range on HMM: 1-170/182.0
NIDFSQSENVELYDTNRvkgggeadffyhgstltipsvtTKSTILAQLAIVDSPQ------------SLESFWIMVASQKIQRLFILLgeeeldkptLSE
|.| ... || .| . |.| | . . |. ....|. |. ...|. . |
nldknrysdilpydhsr......................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eel
YFPEDFkefktirvnnrktvpkteeqantqlyyevvpkdcaeAPFAMIEICDFWPDAKIPTmgYNRIAATAASVFEsdidCDASCAIVSNYGAGRAGSFF
|.||.. . .. .||| .|. . . . | | . ... ..| ||.|..
ywpell....................................erlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlv
VAVLAIEKlqageAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.| | ... .. |. |||.|| ...|..|| | . ..| .
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel
|
|||||||||
| subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 166-399 | 4.4e-11 | 37.2 | In-house | 46-276 (315) | alignment | ||
Range on Protein: 166-399
Range on HMM: 46-276/315.0
DFSQSENVELYDTNRVKG-----GGEADFFyhGsTLTIPSVTTKSTILAQLaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE---DF
. .|. .|..||| . |.. . |.|| . . .| . |.. || || .|. . .. .| || |.|. |
kknryknilPldsarvkleviddsPdsdyi..n.asyiksvdddkayiasq..gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads
KEFKTIRVNNRKTVPKTEEQAnTQLyyeVVPKDCAEAPFAMIEICDfWPDAKIPTMGYnRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAI
|| .|.|. .. . |. | .| |. | . . . . ||| .. . | .. . | . |.||.| . . .
vefGsikvellsleadtdgva.rkl...vtrkseesrtvtqfqfte.wPdkGvdkqts.sllklikevkadngkkefsllvhcsaGvGrtGvvisidevv
EKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.... ... .. .. .|..|| . | .| | | . | .
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 167-397 | 1.9e-38 | 127.6 | Pfam-A | 4-234 (235) | alignment | ||
Range on Protein: 167-397
Range on HMM: 4-234/235.0
FSQSENVELYDTNRVKG---GGEADfFYHGSTLTIPSvTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEF
..... || .||| .|. | ... .... . ..|. |..| ....|.|| || .|.. ...| .|| .. ....|.| |.....
knRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty
KTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEA-PFA-MIEICDFWPDAKIPtMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIE
..|.|... . ..|......|. . |...| .. . . ||| ..| .. . . .| .| ...... ... |.||.|.| .. ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
.|.|.| .....| ..|.||| ....|.||.| | . |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 167-397 | 1.9e-38 | 127.6 | In-house | 4-234 (235) | alignment | ||
Range on Protein: 167-397
Range on HMM: 4-234/235.0
FSQSENVELYDTNRVKG---GGEADfFYHGSTLTIPSvTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEF
..... || .||| .|. | ... .... . ..|. |..| ....|.|| || .|.. ...| .|| .. ....|.| |.....
knRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty
KTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEA-PFA-MIEICDFWPDAKIPtMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIE
..|.|... . ..|......|. . |...| .. . . ||| ..| .. . . .| .| ...... ... |.||.|.| .. ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
.|.|.| .....| ..|.||| ....|.||.| | . |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
|
|||||||||
| subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 170-399 | 3.5e-08 | 27.0 | In-house | 49-275 (515) | alignment | ||
Range on Protein: 170-399
Range on HMM: 49-275/515.0
SENVELYDTNRVKG-----GGEADFFYhGStlTIPSVTTKSTILAQLaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE---DFKEFK
.|. ||..||| . |.| | |||. . . .| . |.. || .| ... . .. .| || ..|.|. | .|
yknilPydsvrvklevindnPhsdyfn.as..yipsfdndkayiasq..gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG
TIRVNNRKTVPKTEEQAnTQLyyEVVPKDCaEAPFAMIEICDfWPDAKIPTMgYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ
.|.|. . |. .| .|. | . . . ||| .| . . | . . | |.||.| . . . . .
sikvelvsleactggik.rkl..tvlkgdd.srtvtqfhfte.WPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahak
AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
... .. .. .| .|| . | || | | . | .
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
|
|||||||||
| subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 170-394 | 4.1e-07 | 24.4 | In-house | 9-233 (237) | alignment | ||
Range on Protein: 170-394
Range on HMM: 9-233/237.0
SENVELYDTNRV--KGGGEADFFYHGSTLTIPSVTTKSTILAQLAIVDspqSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDfKEFKTIRVNn
|. || .|| || | . . . | | |. | || . | . || || .| . .| | | .. .|.|. .. .. |
ygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgples...scddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvl.
RKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIAATAASVFESDIDCDASCAIVSN-YGAGRAGSFFVAVLAIEKLQAGE
.. | || .. . .. | .| .| ||| .| . . .| ... |. | ||.| |.| . . . .
tvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk
APNIKEIALSVRSQRPAAIETLSQYMFTYV
.| . |. .|| |.| ||.| .
vvdiynyvysieedrpyiiqtkdqyvfihq
|
|||||||||
| subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 204-400 | 1.6e-21 | 70.3 | In-house | 115-309 (346) | alignment | ||
Range on Protein: 204-400
Range on HMM: 115-309/346.0
KSTILAQLAIVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED--FKEFKTIRVNNRKTVPKTEEQANTqlyYEVVPKDCAEAPFAMIEI
. |.||| ... .| || |. ..|. ..... .. | . | | . |. .. . .|||.. . . | ||.|. ... . .
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeyt...ievlpegnsdsvicqvhh
CDFWPDAKIPTMGYNRIAATAASVFESDIDCdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
| . | | | .. | .|| .|.||| || |. ||..|. | ||| || ... ||| ..|...|| | | . |
hapwkhlqqppktlpiikmihqflsekqvqn.agvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
|
|||||||||
| subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 204-399 | 3.4e-18 | 60.7 | In-house | 52-241 (250) | alignment | ||
Range on Protein: 204-399
Range on HMM: 52-241/250.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPtLSEYFP-EDFKEFKTIRVNNRKTvpktEEQANTQLYYEVVPKDCAEAPFAMIEI-
|. | .| .. ...| || || .|.. . .| .| .| ..|.| | ... ..|. .. || |. . .. | . . ..
kafiatqgPlq...atiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllsk....eefadytkrklklskakkaderivrqlh
CDFWPDAKIPTMgYNRIAATAASVFESDIDCDASCAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
||| .| . .. . . | |. .... || | ||.|.| . .|.|. . .. .. .| .|| |.|.|.||.| | |.| .
fvvWPdkgvPev.atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
|
|||||||||
| subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 204-396 | 9.2e-08 | 26.5 | In-house | 51-236 (239) | alignment | ||
Range on Protein: 204-396
Range on HMM: 51-236/239.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVvpkDCAEAPFAMIEICD
|. | .| .. | || |. .. . .| | | | .|.|. .. .|| ||| .. | . .| .| .
kayiatqgcve...issgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhft
FWPDAKIPTMGYNRIAaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
||| .| . . . . | . | ||.|.|.| . . . .. .| . ..| .|| ..| ||.| ..
vwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
|
|||||||||
| subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 204-396 | 1e-07 | 26.4 | In-house | 52-237 (239) | alignment | ||
Range on Protein: 204-396
Range on HMM: 52-237/239.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVvpkDCAEAPFAMIEICD
|. | .| .. | || |. .. . .| | | | .|.|. .. .|| ||| .. | . .| .| .
kayiatqgcve...issgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhft
FWPDAKIPTMGYNRIAaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
||| .| . . . . | . | ||.|.|.| . . . .. .| . ..| .|| ..| ||.| ..
vwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 207-393 | 8.7e-10 | 34.1 | In-house | 22-154 (172) | alignment | ||
Range on Protein: 207-393
Range on HMM: 22-154/172.0
ILAQLAIvdSPQSLESFWIMVASQKIQRLFILLGEeeldkptlseyfpedfkefktirvnnrKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWP
..| .. . |..|| |. ...|. .. | .. . |. .|. . |..| .| .. . ..|...|
fiatqgp..lrntladfwrmlkelgithivnltel...........................lydpellerlgiqylylpwpDhgvpllellleflefid
D--AKIPtmgynriaataasvfesdidcDASCAIVSNYGAGRAGSFFVAVLAIeklQ-AgeapNIKEIALSVRSQRPAAIETLSQYMFTY
. |. | . ... .| ||.| . .| | . . .. |. ||..|| |... |||.| |
ellalsp.....................ggpvlVHCsaGvgRtgtlvaaylml...lgl....sleeavalvrekRpgavqnpsqyrfly
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 209-393 | 8.7e-11 | 37.3 | In-house | 17-163 (174) | alignment | ||
Range on Protein: 209-393
Range on HMM: 17-163/174.0
AQLAIVDSPQSlesFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEdfkefktirvnnrktVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDA
| . . | . || |. ...|. .. || |.||.. |.|| .. .|. . |..| .| ... ..|...| .|
prliagqgpla...fwemlkelgittvvmlleekelglykcinywpe...............lredlerlgiqylylpwpDhgvpdlsillefvkfveea
KiptmgynriaataasvfeSDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQaGEAPNIKEIALSVRSQRPAAIETLSQYMFTY
|. | . ... . | ||.| . .| | . | . .. .. ..|.||| ...| |||.| |
l..................se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 211-395 | 2.9e-11 | 38.9 | In-house | 19-168 (176) | alignment | ||
Range on Protein: 211-395
Range on HMM: 19-168/176.0
LAIVDS--------PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEdFKEFKTirvnnrktvpkteeqantqlyyevvpkdcaeapfamIEIC
|.. . |..|..|. |. ...|. .. |. | ||.. . |.|| ..... ..
lilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................................qylh
DFWPDAKIPTMgynRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEklqaGEAPNIKEIALSVRSQRP-AAIETLSQYMFTYVI
||| .|.. .. .. .. .. . .. | ||.| . .| | . . .. |. ||.||| |..| .|| | |
lpwpDhgvpdl...elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyef
|
|||||||||
| subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 213-399 | 3e-07 | 24.7 | In-house | 90-277 (287) | alignment | ||
Range on Protein: 213-399
Range on HMM: 90-277/287.0
IVDSP--QSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF----KEFKtIRVNNRKtvpKTEEQANTQLYYEVVPKDCAEAPFAMIEICDfWP
| .|| . . || .. .... . .| |.| |. .|.||. |.. |.. |.. .... . .| . |. .. .| . |.
iaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyn.iellnee...vnagyierklevknknkagdkqqvkqyqitn.Wd
DAK-IPTmgYNRIAATAASVFES-DIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. ... .. | . . ..| . . ||.. | | .|.| . . .. .. | | |.| .. | .||.| . | |.|
stgkvte..pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 214-391 | 8e-08 | 27.6 | In-house | 33-162 (178) | alignment | ||
Range on Protein: 214-391
Range on HMM: 33-162/178.0
VDSPQslESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKefktirvnnrktvpkteeqantqlyyevvpkdcaeapfaMIEICDFWPDAKIPTm
. |. .... .. ..|. . | .| || .. . .|.||.. . .. .|| . |.
gslpp..addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDhgvpd.
gYNRIAATAASVFESDI-DCDASCAIVSNYGAGRAGSFFVAVLAIEKlqageAPNIKEIALSVRSQRPaAIETLSQYMF
.. . |. . ... ... ..| ||.|.. .| | .. .. |. ||..|| .... .|. .
.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 215-394 | 1.6e-06 | 23.4 | In-house | 19-147 (151) | alignment | ||
Range on Protein: 215-394
Range on HMM: 19-147/151.0
DSPqsLESFWIMVASQKIQRLFILLGEEELDkpTLSEYFPEDFKEFKTIRVNNRKTVPkteeqantqlyyevvpkdcaeapfamieicdfwpdakiptmg
. | |. |. ......|. . | .||| . .. ||.|| |.. | . . .. .
ggp..ladflellkelgiktivnlrseeerg..ycpeylpelgievlhipildwpdpg..........................................
YNRIAATAASVFESDIDC-DASCAIVSNYGAGRAGSFFVAVLAIEKlqageaPNIKEIALSVRSQRPAAIETLSQYMFTYV
. .......| .|. . ... . | || | . ...| ... .. |. .|..|| .. . |..| .
lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
|
|||||||||
| subfamily_PTPN12_pd | Subfamily PTPN12 | 216-399 | 1.2e-11 | 39.0 | In-house | 92-276 (290) | alignment | ||
Range on Protein: 216-399
Range on HMM: 92-276/290.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKE---FKTIRVNNRKTVPKTEEQANTQLYYEVVpkdCAEAPFAMIEiCDFWPDAKIPT
|. |. || |. ..... . .. | ||.| |.|| .| | ...|.. . ... .| |. .. . .. ||| .|.
LpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfh.YtaWPDhgvPs
MgYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAP---NIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
... . ..| | . || .. | ||.| . .. | |.|. | .. .. |..| ||.|.. | || . | . .
s.aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
|
|||||||||
| subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 216-399 | 3.2e-10 | 34.5 | In-house | 73-263 (270) | alignment | ||
Range on Protein: 216-399
Range on HMM: 73-263/270.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGY
| .|.||| |. ..| . . .. | || . . |.|.. || ... . |.. .||... . .. .. .| . ||| .|..
lpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreed
-----NRIAATAASVFESDIDCDAS-CAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . .. . | .| . | . .| | ||.| . . |.. |. . .. .| .| .|.| ... || | | ..|
sslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
|
|||||||||
| subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 216-396 | 5.1e-10 | 33.8 | In-house | 101-275 (315) | alignment | ||
Range on Protein: 216-396
Range on HMM: 101-275/315.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQlyyEVVPKDCAEAPFAMIeiCDFWPDAKIPTMGY
..|.. || .| ..| .. .| . | .| .|.|.. . | | .. .|| | || .| . . . |||...|
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlh..ytswpdmgvpkyti
NRI--AATAASVFESDIdcdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
. . |. .... .. . . | ||.|.| .....| .| .. .. ||..| ..... || | | .
plmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
|
|||||||||
| subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 216-404 | 6.8e-09 | 30.6 | In-house | 77-262 (284) | alignment | ||
Range on Protein: 216-404
Range on HMM: 77-262/284.0
SPQSLESFWIMVASQKIQRLFILLgeeeldKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEqanTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTM
. .|. || |. ... . .| | |.|.| . .. . . ..| ..|| . . .| | | | ||| | .
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdy
GYNRIAATAA-SVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT---YGLKHV
. . .. . ..| . |. . |.||.| . | ..... . .. .. .| ||. .. | ||.| |. | .| |
psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
|
|||||||||
| subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 216-401 | 9.3e-09 | 30.0 | In-house | 113-295 (319) | alignment | ||
Range on Protein: 216-401
Range on HMM: 113-295/319.0
SPQSLESFWIMVASQKIQRLFILLgeeeldKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEqanTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTM
. .|. || |. ... . .| | |.|.| . .. . . ..| .|.| . . .| | | | ||| |
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdy
GYNRIAATAA-SVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT---YGL
. . . . ..| . |. . |.||.| . | ..... . .. .. .| ||. .. | ||.| |. | .|
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
|
|||||||||
| subfamily_PTPRG_pd | Subfamily PTPRG | 216-394 | 1.3e-08 | 28.5 | In-house | 100-281 (563) | alignment | ||
Range on Protein: 216-394
Range on HMM: 100-281/563.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-KEFKTIRVNNRKT---VPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP
... .. || |. |. . . .. .| . |.|.| .......|. .. . |... . |.| . . . ||| |
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP
TMGYNRIAATAASvfESDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYV
. . | . .| .| ..|.||.| . | ....|. .| |. ... .|.||. ..| ||.| .
ehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd
|
|||||||||
| subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 217-399 | 2.4e-19 | 64.7 | In-house | 109-289 (298) | alignment | ||
Range on Protein: 217-399
Range on HMM: 109-289/298.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE-DFKEFKTIRVnnrkTVPKTEEQANTQLYYEVVPKDC--AEAPFAMIEICdFWPDAKIPTM
....| || || ..|. . .| ||||| . ..|.|. ... .|.| .. ..||.|. | | | ... ||| .|..
tetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv....sllskeefadlivrklkvskkkeekerevrqlhft.sWpdkgvpen
GyNRIAATAASVFESDIDCD-ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . . . | | .. .. . | ||.|.| . .|.... . . .. .| .||.|..| .||.| | . | .
a.tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
|
|||||||||
| subfamily_PTPRD_pd | Subfamily PTPRD | 217-421 | 4.4e-17 | 56.9 | In-house | 101-305 (564) | alignment | ||
Range on Protein: 217-421
Range on HMM: 101-305/564.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTvpktEEQANTQLYYEVVpKDCAEAPFAMIEICDF--WPDAKIPTM
....| || || |... .| || .| ...|.||. ... . |. .. || |. .. . |. . ... | ||| .|.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleee....eeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpes
GyNRIAATAASVFESDiDCDASCAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY---GLKHVKDPAL
. . . . | .. .|| . .| . | || | | | .|.... . .| .. .|.||.| ..| .||.| . . | . | ..|. .|
a.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl
KIKTEKVISQLE
| ...|. .. |
kqhlqkLaevee
|
|||||||||
| subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 217-399 | 6.7e-13 | 43.3 | In-house | 83-267 (274) | alignment | ||
Range on Protein: 217-399
Range on HMM: 83-267/274.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKE-----FKTIRVNNRKTVPKTEEQAnTQLY--YEVVPKDcaeapfAMIEICDFWPDAK
|. .. || |. ...| . .| .| .. ..|||.. . .. . ....|.| . . . ..|. | ... . ||| |
pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysv.rklvlkylerers......vkhywytdWPdhk
IPTMgYNRIAATAASVFESDIDCDASCA---IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| | . . . | || . .| .| . | ||.| | . .|. .|.. . .. .| .| .| ..| .|| . . . |
sPdd.antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
|
|||||||||
| subfamily_PTPRK_pd | Subfamily PTPRK | 217-398 | 4.8e-10 | 33.7 | In-house | 96-275 (314) | alignment | ||
Range on Protein: 217-398
Range on HMM: 96-275/314.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTqlyYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMG
.. .. || .| .. . .| | . ..|.||| . .. |.|. .| ...| . . . | . . .. .| ||| ..|.
qetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvri...frveklargqeeirevrqfqflgWpdhdvPvsa
YNrIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
. . . | .|. . . . ||||.| | . .. .. . .. ... ..||... .|| ||.| | ..|
tg.llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 217-393 | 1.8e-09 | 33.0 | In-house | 19-143 (152) | alignment | ||
Range on Protein: 217-393
Range on HMM: 19-143/152.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFpedfkefktirvnnrktvpkteeqantqlyyevvpkdcaeapfamIEICDFWPDAKIPTMGYN
|..|..|| |. ...|. . | ..||.|. .|. .. .||| |..
pntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdlsql
RIAATAASVFEsDIDCDASCAIVSNYGAGRAGSFFVAVLAIeklqagEAPNIKEIALSVRSQRPAAIETLSQYMFTY
. . . . .| . ... .| ||.| . .| | . ...|. ||..|| |... .|..| |
llflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 217-402 | 4.8e-09 | 30.7 | In-house | 95-292 (297) | alignment | ||
Range on Protein: 217-402
Range on HMM: 95-292/297.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEFKTIRVNNRKTVPKTEeQANTQLYYEVV-PKDCAE-APFAMIEicdfWPDAKIP
.. . || || |.. . . .| . ..|.| |. .|| ..|.| ... . . ..| . | .. . | .. ||| .|
kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleiknvkteesrkvthfqfls....WPdyGvP
TMGYNRI-----AATAASVFESDI------DCDASC-AIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . . . . ... ... ... . | ||.| | .....|. . .. | .|.|| .| | ||.| |. | |
ssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
GLK
|.
ale
|
|||||||||
| subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 217-399 | 1e-08 | 29.4 | In-house | 101-282 (290) | alignment | ||
Range on Protein: 217-399
Range on HMM: 101-282/290.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNrktvpKTEEQ--ANTQLYYEVVPKDCAeAPFAMIEICDFwpdAKIPTM
.. | || .. .|. . .|. . | .| . |.|. |.. .... ||. .. || |. | .. .. . ..
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl.....lneetlneyierklevknknsa.gakqsvtqyqi...tnwdst
GYNRIAATAASVFESDI-----DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| .| .|.| . . . | . . ||.. | .| .|.| . .. .. | |.|.| ..| || . . | |||
gkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
|
|||||||||
| subfamily_PTPN6_pd | Subfamily PTPN6 | 217-399 | 2.2e-07 | 25.1 | In-house | 108-296 (306) | alignment | ||
Range on Protein: 217-399
Range on HMM: 108-296/306.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKT--IRVNNRKTvPKTEEQANTQLYYEvvPKDCAEAPFAMIEI-CDFWPDAKIPTM
.. .. || || .. . . .. | | | . |.|. .. .. |.|.| . .... .| . |. .. ... |||. .|.
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvs..kkkkkkeerevfqyhfksWPdhgvpkd
GYNRIaATAASVFESDID---CDASCAIV-SNYGAGRAGSFFVAVLAIE---KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . . | . . .| .| . | || |.| | . .. | .|... |||.|| . | .|| | | . .|
pgavL.dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
|
|||||||||
| subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 217-397 | 3.2e-07 | 24.2 | In-house | 101-276 (439) | alignment | ||
Range on Protein: 217-397
Range on HMM: 101-276/439.0
PQSLESFWIMVASQKIQRLFILLGEEELDKptlseYFPEDFKEF---KTIRVNNRKTVPKTEEQAntqlYYEVVPKDCAEAPFAMIEIC-DFWPDAKIPT
.. ..|| .| .| .. | | | |.| | . . ..||. .|. . . . .| .| ..... ||| ..|.
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirg....fkvfnerdttekertvlqfhyiawpdknvpa
MGYNRIAATAASvfESDIDCDASCA--IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
. | .| | . . | ||.|. .|.|.|.. . .|| | .| || ...| ||.| | |
qashvldflrai..nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
|
|||||||||
| subfamily_PTPRA_pd | Subfamily PTPRA | 218-404 | 4.5e-15 | 50.3 | In-house | 112-302 (330) | alignment | ||
Range on Protein: 218-404
Range on HMM: 112-302/330.0
QSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTVpKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMG
...| || |. || . . .| .| .. |.|.. . |||. .... ... . .. . .|. . | . ... | ||| .|. .
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep
YNRIAATAASVFESDIDCDaSCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLK---HV
. .. . .. . . |.||.|.| | .|...| . .. |. ..| ||| . |. || | | . | | | .
iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 218-399 | 3.5e-10 | 35.5 | In-house | 33-224 (272) | alignment | ||
Range on Protein: 218-399
Range on HMM: 33-224/272.0
QSLESFWIMvASQKIQRLFILLGEEELDKPTLSEYFP-------------EDFKEFKTIRVNNRKTVpkTEEQANTQLYYEVVPKDCAEAPFAMIEICDF
. ..|| . ....| . | .|||... . | | . . .. .|| . ... . . .. . . ||. |. .
ltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee..llldyilrellltlllsagearevmhlhytd
WPDAKIPTMGYNRIAATAASvfesdidcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPN--------IKEIALSVRSQRPAAIETLSQYMFTYVIA
||| .|. . .. . .. . . . . | .| | . ...| .. . . . . |. .|.|||.|..| ||.| | ..
wpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal
LTY
| .
lel
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 218-398 | 2.2e-07 | 26.4 | In-house | 155-278 (314) | alignment | ||
Range on Protein: 218-398
Range on HMM: 155-278/314.0
QslesfwimvasqkiqrlfillgeeeldkptlSEYFPEDFKEFKtirvnnrktvpkteeqantqlyyEVV--PKDCAEAPFAMIEIcdFWPDAKIPTMGY
. .|. ..|....| |.. |... .. . . | .|| |. .
g...............................neptaadlellk.......................eelydpelferlgikylri..pvpDgsaplled
nrIAATAASVFESdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLqaGEapNIKEIALSVRSQRP-----AAIETLSQYMFTYVIALT
. . . . | | . .. . | ||.|.| || . . .| | ...|. ||..|| .||.| || | . . |
..fdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleealedvrlkRpinpnpgfieqleqyefilealle
|
|||||||||
| subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 219-402 | 2e-06 | 21.7 | In-house | 93-271 (281) | alignment | ||
Range on Protein: 219-402
Range on HMM: 93-271/281.0
SLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK---EFKTIRVNN-RKTVPKTEEQANTQLYYEvvpkdcAEAPFAMIEICDFWPDAKIPTMG
. || |. .. . .| | .. .|||| . . .| . |. || |. . .| || |. . . ||| ..|
tradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye......getrlithwlwkewpdwqvpess
YNRIaataaSVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRS-QRPAAIETLSQYMFTYVIALTYGLK
. .. . | | ||.|... .|.. ... |.||.| .| | |...|| |||. . . | .|.
evml.....kilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
|
|||||||||
| subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 265-396 | 1.6e-08 | 28.5 | In-house | 196-332 (347) | alignment | ||
Range on Protein: 265-396
Range on HMM: 196-332/347.0
VNNRK-TVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAATAASVFESD------IDCDASCAIVSNYGAGRAGSFFVAVLAI
.| |. .| . . . ||| . |.|| || . | || | | . .| | | || .. | .. . | |. . .. . |
intravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiii
EKLQAGEAPNIKEIALSVRSQRpAAIETLSQYmFTYVIA
|.. .| .|. .. .| || | . |.| . .|| |
eqvldgktpdcddlfkkmrdqr.agvftmsif.ytyair
|
|||||||||
| PTPc_DSPc_SM00012 | 304-396 | 6.5e-16 | 53.8 | In-house | 9-103 (105) | alignment | |||
Range on Protein: 304-396
Range on HMM: 9-103/105.0
FWPDAKIPTMGyNRIAATAASVFESDIDCD--ASCAIVSNYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
||| ..|. . . | . ..| .. ... ... ... |.||.| | .. .....|... . ..|..| ..|.||| ...|. ||.| | .
gwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 304-395 | 7.4e-06 | 21.2 | In-house | 54-138 (145) | alignment | ||
Range on Protein: 304-395
Range on HMM: 54-138/145.0
FWPDAKIPTMGynRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEklqagEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
||| .|.. .. .. |. .. . ... . | ||.|.. .| | .. . .. |. |||||| |... .|. | |
pwpDhgvpdll..ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyef
|
|||||||||
| subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 338-395 | 3.5e-07 | 24.5 | In-house | 197-254 (267) | alignment | ||
Range on Protein: 338-395
Range on HMM: 197-254/267.0
IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
. . | ||.|.|.|. .|... . .| . . .||||.. ..|. .|.. . .
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 339-398 | 9e-08 | 26.3 | In-house | 234-293 (297) | alignment | ||
Range on Protein: 339-398
Range on HMM: 234-293/297.0
VSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
| ||.| . ..||. . |... | .|.||. ..|| |. . | ..|
hcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 341-400 | 4.8e-06 | 20.5 | In-house | 255-315 (319) | alignment | ||
Range on Protein: 341-400
Range on HMM: 255-315/319.0
NYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
|.||.| . .||..|. .. .| .. ||| .| |. | || | | .. |
sdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
|
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