Gene F40G12.10 in Caenorhabditis elegans

Synonym: CELE_F40G12.10, F40G12.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP081_AA protein Get Run
CeleP081_AA_123-402 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 115-404 3.6e-41 136.9 In-house 18-303 (308) alignment
Range on Protein: 115-404
Range on HMM: 18-303/308.0
SGNVKNVEKGVKVWIELLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGgGEADFFYHGSTLTIPS-VTTKSTILAQLA
| .|.. .  |. ...||||..... .| ||. .  .| .|| .. ....|.|. .. ..  || .|||  .| . ... |  ...|   ..  |..|  
silvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgP

IvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE----DFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDA
    |...|.|| ||  |...    |  ..| ....  .|.|.    ...|.. ..|.....     ..  |. ..|...... |  . ..  .  ||| 
l...pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhytnWpdh

KIPT--MGYNRIAATAASVFesdidCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHV
..|.    . ..   . ...      .  ... .. | ||.| | .. |..| |...  ... |.   .|.||| ...|..||.| | ..| | ....
gvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 120-416 1e-118 390.2 In-house 2-301 (302) alignment
Range on Protein: 120-416
Range on HMM: 2-301/302.0
NVEKGVKVWIELLEKMDFRKT-----MEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTtKSTILAQLAIV
.||.... |.|  |.... |.     ...|||.|||||.|||||.|||||....|||.|...|.|.||...|.|.....|....|..| .|.|||||..|
kveeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkv

DSPQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP---EDFKEFKTIRVNNRKtVPKTEEQAnTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP
||..|.|.|| ||...||....||.|||||.| ||||.||   .|.||.....||||| |.|.||.. |....||.|..|.....|.......|...|.|
dsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp

tMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKDPALKI
 . |.....|||.||...|..|....|||..||||||.|.....|.||||.|..||||||. |.|||||.|...|.||...|...|.|..|.|..|. | 
.vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekk

KTEKV
|.|.|
kkeev

0039614 (Phosphotyrosine protein) phosphatases II 122-403 3.1e-38 127.3 In-house 15-292 (297) alignment
Range on Protein: 122-403
Range on HMM: 15-292/297.0
EKGVKVWIELLEKMDFRKTMEPEFKPIDTMKADlEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADF-----FYHGSTLTIPSVTTKSTILAQLAivdS
  .|. .. ||||.... ... ||. .  .| |  .. ....|.|. .. ..  || .|||  .| ..     ... | .. ....|.  |..|     .
plsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP...l

PQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFPEDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAeaPFAMIEICDFWPDAKIP--TMG
|...|.|| ||  |... .  |  ..||.. .  .|.||.  ......|...|.     ..  |. . ||.....    . .   .  ||| ..|  .  
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkveh...ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslel

YNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
  ..   . ...... . .  ... .. | ||.|.| .| |..| |. .  ....|.   .|.||| |..|.|||.| | ..| . ...
lleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0051299 (Phosphotyrosine protein) phosphatases II 122-399 1e-34 115.8 In-house 8-285 (288) alignment
Range on Protein: 122-399
Range on HMM: 8-285/288.0
EKGVKVWIELLekMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAIvds
|. .|.. .||  ... .... ||. .  ...||. .. ....|..  .. ..  || .|||    .| | . ... | ....  . |  |..|      
eellklvlkll..angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl...

PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPK----DCAEAPFAMIEICDFWPDAKIP
|...|.|| ||  |...   .| ...||.. .   |.| ....... |.|......    ..  |. . ||...     . |  . ..  .  |||  .|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

TmGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.   . . .    | ..  ...  ... .. | ||.| | .. |..| |.... ... |.   .|.||| ...|..||.| | ..| |
d.spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0040438 (Phosphotyrosine protein) phosphatases II 124-432 1.9e-41 137.7 In-house 4-308 (317) alignment
Range on Protein: 124-432
Range on HMM: 4-308/317.0
GVKVWIELLEKMDFrKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQS
... ....| |.|| . .. ||. ....| |  .. ....|.|. .. .. .|| .|||    || . . ... |  ..|. ..|  |..|      |..
dlllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPl...pnt

LESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYN
.|.|| ||  |... .  |  .|||....  .|.| ..........|......    ..  | .  ||..... |  . ..  . .||| ..|  .    
vedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdlll

RIAATAASVFEsdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKDPALKIKTEKV
..   . ...|   | .  ... .. | ||.|.| .| |..| |. .. ....|.   .|.||| |..|..||.| | ..| | ....... .. .  |.
dfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl

ISQLEQFACEKMTEED
. .|. .|........
lklliplalddvklke

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 125-406 3.5e-13 44.2 In-house 3-283 (307) alignment
Range on Protein: 125-406
Range on HMM: 3-283/307.0
VKVWIELLEKMDFRKtMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRV--KGGGEADFFYHGSTLTIpSVTTKSTILAQLAIvDSpqSLES
|| |..   ..  .. .  ||. .  .. .    .||. | |  . ..|.  | .|.  |  | |  . |   | | ..  |  | ||    ..  .  |
vkpwvqrtldkgvqa.lvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgi.aikpkkficaqgpl.en..tqys

FWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-------KEFKTIRVNNR--KTVPKTEEQANTqLYYEVVPKDCAEApFAMIeICDFWPDAKIPTM
|| |.  .|.. . .|    || |    .|.| .        .. .|| |.|   |..   |.  |     .|.  . . .    .   . |||  .| .
fwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkvdwaqksrt.iqhl.qwenwpdrgvpqi

GYNRIAATAASVFEsdidcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKD
  . |    |  ..          .    | ||.|.     |  .|. ||.   ..|..   .||||. ||.|  ||.. . . | | |.  |.
nltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke

0045450 (Phosphotyrosine protein) phosphatases II 126-400 4e-37 124.0 In-house 14-304 (307) alignment
Range on Protein: 126-400
Range on HMM: 14-304/307.0
KVWIELLEKMDFRKTMEPEFKPIDTMKADLE---KCQAFKKNIDFSQSENVELYDTNRVKGGG-----EADFFYHGSTLTIPSV-------TTKSTILAQ
 ... ||.. ||.  .. ||. .  .. .|    .. ....|.|. .. .. .|| .|||        | . ....|  ..|..        ..  |..|
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

LAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDfKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPK-DCAEAPFAMIEICDFWPDAK
      |...|.|| |.  |... .  | ...||...   .|.|.. .|..|..    ... .....  | ...|| ..  . |  . .. ..  ||| .
gPl...petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg

IP--TMGYNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEA---PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
.|  .    ..   . ...|.. ...  ... .. | ||.|.| .| |... |....    ... |.   .|.||| |.....||.| | ..| . 
vppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0047943 (Phosphotyrosine protein) phosphatases II 129-399 2.3e-36 121.1 In-house 2-271 (273) alignment
Range on Protein: 129-399
Range on HMM: 2-271/273.0
IELLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQSLESFWIMV
. ||||........ ||. .  .| .|. .. ....|.|. .. ..  || .||| |.. . ... | .. . .. |  |..|      |...|.|| ||
llllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk.fiatqgPl...pntvedfwrmv

ASQKIQRLFILLGEEELDKPTLSEYFPED----FKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAAT
  |... .  |  ..||....   |.|..    ..... ..|.....     ..  |.   |...... |  . ..  .  ||| ..|  .    ..   
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

AASVFESDIDCdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. ...|....     .. .. | ||.|.| .. |... |...  ....|.   .||||| ...|..||.| | ..| |
vrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 130-402 9.6e-13 42.5 In-house 15-289 (305) alignment
Range on Protein: 130-402
Range on HMM: 15-289/305.0
ELLEKMDfrKTMEPEFKPIDTMkADLEKCQAFKKNIDFSQ--SENVELYDTNRVKGGGEADFF-YHGSTLTIPSvTTKSTILAQLAIvDspQSLESFWIM
. |||.   . .  ||. .  .  |.|| .|||.  .  .    .|   | ||||  |       |   .. |.  .|  | .|  . .  ..   || |
rtlekgp..aglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstpt.npkrfictqapl.e..ktcadfwym

VASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKD-----CAEAPFAMIEIC-----DFWPDAKIPTMGYn
   .|.. .|.|    |      .|||. . |.  ... ...| . | |  .. ..  .   |        | | .  .         |||  .|.    
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl.

riaaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAP-NIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLK
    .   ..|         ..    | ||.||  .    ...| ||.   . . |   .| ||  .|.|  ||.| . . | | .|
....ailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

0036941 (Phosphotyrosine protein) phosphatases II 131-403 1e-41 138.5 In-house 5-280 (297) alignment
Range on Protein: 131-403
Range on HMM: 5-280/297.0
LLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQSLESFWIMVAS
||||..|.  .. ||. .. .... . .......|..  .. ..  || .||| ..| . ....| ....... |  |..|      |...|.|| ||  
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk.fIatqgPl...pntvedFWrmvwe

QKIQRLFILLGEEELDKPTLSEYFP---EDFKEFKTIRVNNRKTVPKtEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPT--MGYNRIAATAAS
|... .  |  ..||....  .|.|   ....... ..|.....  . ...  |. . ||..... |  . ..  .  ||| ..|.    . ..   . .
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

VFeSDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ---AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
|  . .  .    . .. | ||.|.| .| |... |.     . ..|.|. ...|.||| |..||.||.| | . | . .|.
vl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

subfamily_PTPN13_pd Subfamily PTPN13 131-398 3.9e-18 60.7 In-house 4-267 (273) alignment
Range on Protein: 131-398
Range on HMM: 4-267/273.0
LLEKMDFRkTMEPEFKPIDTMKADlEKCQAFKK--NIDFSQSENVELYDTNRVKGGGEADfFYHGSTLTIPSvtTKSTILAQLAIVDSPQSLESFWIMVA
| .|.|   . . ||| .  .|.  ..|.  ||  | |  .  ||  ||  ||| |.|.  .   | . .|    | .  . ..    |.. . || || 
lqkkldqq.qPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvw

SQKIQRLFILLGEEELDKPTLSEYFPEDFKefKTIRVNNRKTVPKTEEQANTQLY-YEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIAAtAASV
 || . . ..  | | .|     |.||  .  |.. |.|| .| . . |   ..   ..  || . .    .   .|  ||| ..|.   . .   .| |
eqkaeviamvtlekekgkvkchrywPeskn..kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqf.vaev

feSDIDCD-ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
    .. | .  ..    | ||.|.. .   ... ..  .  ..|||  ..| || . . |  ||.| | ..|.
..rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

0043336 (Phosphotyrosine protein) phosphatases II 134-399 1.1e-39 132.0 In-house 15-276 (278) alignment
Range on Protein: 134-399
Range on HMM: 15-276/278.0
KMDFRKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAivdSPQSLESFWIMVAS
......... ||. ....| |  .. ....|.|. .. .. .|| .|||    || . . ... |... ..|..|  |..|     .|...| || ||  
llnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgP...lpetvedFwrmvwe

QKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFE
.... .  | ...||....  .|.|..........|...|.     ..  |.   ||... . |  . ..  .  ||| ..|  .  . ..  .. ...|
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh...lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

sdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
   |..   .. .. | ||.| | .. |..| |. .  ... |.   .|.||| |..|.|||.| | ..| |
...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 137-397 1.6e-13 45.4 In-house 19-276 (288) alignment
Range on Protein: 137-397
Range on HMM: 19-276/288.0
FRKTMEPEFKPIDTMKADLEKCQAF-KKNIDFSQSENVELYDTNRVKGGG---EADFFYHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKI
 |. .. |.. . ... . .....   .| .  . .|.  || .|||  .   ||.  |  ..    .  .|  | .|  .   ..... || .|  .|.
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl...adtvndfWelvyenkt

QRLFILLGEEELDKPTLSEYFPEDFK--EFKTIRVNNRKTvPKTEEQANTQLYYEvvpKDCAEAPFAMIEIcDFWPDAKIPTMGYNRIAATAASVFESDI
. .  | .  | .| .  ||.|.. |  ..  . |  ...  ..|.  . .|  |   |.  |      .    ||| ..|    . ..        .. 
stivmltelveggktkCeeYWPdadkpknyGsvtvtlves.keledfvlrkllle...kkkteleitqyqy.laWpdhgvPeskapllellrqvkvanqa

DcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
|      ..   | ||.| | ..  .|..... .  .. ..   .| ||.  ..||.||.| | . |
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 137-399 8.6e-08 26.2 In-house 17-275 (312) alignment
Range on Protein: 137-399
Range on HMM: 17-275/312.0
FRKTMEPEFKPIDTMKADLEkCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIpsvTTKST--ILAQLAIVdspQSLESFWIMVASQKIQR
  . .  |.| .  . .| | | || |  |. .  |.. .|  |    |. .|. |   . |    ||    . .| ..    ..   || .. |     
tpqqltkeykavgnivsdse.ctaflkfkdlnrypniqcwdrgrftlagdenfyihanfvki...ctkperfvctqgple...ntcthfwqlalslgsts

LFILLGEEELDKPTLSEYFPE--DFKEFKTIRVNNRKT-----VPKTEEQANTQLYYEVVPKDCAEAPFAMIEIcDFWPDAKIPTMgynriAATAASVFe
. .| |  |      ..|  .   | ...  ||            |. ..   ..   ||     |. .   .    |||  .|         ||  .. 
iillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqw.aswpdhgmpds.....cdtalrll.

SDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| .  |    |     | ||.|.. .    |  |.     |.|.. . .| .|  ..... ||...  . | .
savkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 138-399 1.4e-12 42.3 In-house 22-282 (319) alignment
Range on Protein: 138-399
Range on HMM: 22-282/319.0
RKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVKGG---GEADFFYHGSTlTIPSVTTKSTILAQLAIVDspQSLESFWIMVASQKIQR
 ...| ||| ... ..|  .    ..| .  . .|.  ||  ||.     |  .  |  ..  | .   ..  .|  | ..  . .| || ||  ...  
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinas.fidgyqerekfiatqaPle..ntiedfWrmvWeeessi

LFILLGEEELDKPTLSEYFPEDF-KEFKTIRVNNRKtVPKTEEQANTQLYYEVVPKDCAEapfAMIEICDF--WPDAKIPTMGYNRIaATAASVFESDID
. .| .  |  |  |..|.||   .|.  . |.  .   ..|.    .|  .    .       ..    .  ||| ..|. .   . .    . .|   
vvmltklveklkvklkkywpeenfeeyGrlivtlee.eeeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekatsll.dllkrirksrek

CDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 ..   .|    |.|| |.| |   ..|...  .. .. ...  .| ||.  ... .|| | | . | .
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 139-394 7.8e-12 40.0 In-house 22-277 (305) alignment
Range on Protein: 139-394
Range on HMM: 22-277/305.0
KTMEPEFKPIDTMkADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFF---YHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRL
|..| ..| . .   .  . .  ..|   ...... |.|..|..   . .     |  ..        |. |.||  .   .. .. || ..   |.. .
kgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPl...kntvadfWrliveekvsti

FILLGEEELDKPTLSEYFPEDFKE---FKTIRV--NNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDfWPDAKIPTMGYNRIAATAASVFESDI
 .| .  | .|     |.||  .|   |  . |  ...||..   .  . .|   .  .|  .      .. | |||  .|..    .        .   
vmltklveggkdkCrqYWpesktekkefgefsvelksektas...dyieRklkisiededkesrtvlqyqltd.WPdhGvpqfatsllslikrvqkdqkk

DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYV
| . .  .. . | ||.| | .  .|.|.|.. |  .. |.   .||.|. ...|| ||.| . 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 139-401 6.1e-08 26.6 In-house 35-284 (290) alignment
Range on Protein: 139-401
Range on HMM: 35-284/290.0
KTMEPeFKPIDTMKADL-EKCQAFKKNidfsQSENVELYDTNRV--KGGGEADFFyHGSTLtipSVTTKSTILAQLAIVDSpqsLESFWIMVASQKIQRL
... | . | . .. .. .|   ||||    .  .|   |  ||  | |.. |.  |   .     .    ||.| |. |.      .| ||  .|.  .
eklkp.ylpvqylerkifdkntefkkn....rykdvvcndktrvilkdGydGdyv.hanyv...kGlkamfiltqGalkdt...vidiwrmvlqekvaai

FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYY-EVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNrIAATAASVFESdidcDA
 .|    |  |.  ..|.||   |  |.         .....||...    |  ||              |||  ..      .  |  .. .       
vmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla.llrtlrilrka....sG

SCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGL
  ..    | ||.|.|     ... |  | . .. ..  ..|  | ....   ||.    | | .| 
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk

0046845 (Phosphotyrosine protein) phosphatases II 141-403 1.5e-32 108.5 In-house 2-277 (284) alignment
Range on Protein: 141-403
Range on HMM: 2-277/284.0
MEPEFKPIDTMKADLE---KCQAFKKNIDFSQSENVELYDTNRVKGGG-----EADFFYHGSTLTIPS----VTTKSTILAQLAIvdsPQSLESFWIMVA
.| ||. .  .. .|.   .. ....|..  .. ..  || .|||        | . ... | .. ..     ..|  |..|      |...|.|| || 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl...pntvedFwrmvw

SQKIQRLFILLGEEELDKPTLSEYFP--EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKD-CAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAA
 |... .  | ...| ..   . |.|  ....... ..|.....     ..  |.   |..... . |  . ..  .  ||| ..|  .    ..  .. 
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

SVFESdIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGE---APNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
...|. ....   .. .  | ||.| | .. |..| |....    ... |.   .|.||| ...||.||.| | ..| | ...
ellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk

subfamily_Ptp69D_pd Subfamily Ptp69D 141-403 4.1e-15 50.7 In-house 24-289 (307) alignment
Range on Protein: 141-403
Range on HMM: 24-289/307.0
MEPEFKPIDTMKADLEKCQ-AFKKNIDFSQSENVELYDTNRVKG---GGEADFFYHGSTLTIPSVTTKSTILAQLAIvDSpqSLESFWIMVASQKIQRLF
.. |.. . . . |..    . | |    ..|..  .| .|||     |..|  |  .   .    .|. | ||  . ..   .. || |.| |... . 
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv.ea..tigDfWRmiaeqevtliv

ILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTvPKTEEQANTQLYYEVVPKDCAEAPfAMIEICDF----WPDAKIPTMGYNrIAATAASVFESDID
.|  ..| ..   . |.| || ...  | |.  ..  |... .. .|..  . .. .| . .  ..  .    |.| |.| .    .      | |    
mlsnlteknrkkcakYWpiedevqygdilvklvse.ekhsdyiiReldvskkkeesgeve.dsrkvvqyhytgWkDskvPevarg.llklieqvrelykl

CDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
  .   .  . |.||.| |    . ...|.| .  .| |.   .||||.  .. | ||.| |   | |  . 
nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 141-399 5e-15 50.4 In-house 22-279 (318) alignment
Range on Protein: 141-399
Range on HMM: 22-279/318.0
MEPEFKPIDTMKADLEKCQAFKK-NIDFSQSENVELYDTNRVKGG---GEADFFYHGSTLtIPSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLF
.. |.. ..  ..   . .. .. |    .  |.  ||. |||     || .  |  .   |.  . | . .|  | .  |. .| || ||  |. . . 
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinany.idGyrrkkayiaaqaPl..petieDfWrmvWeqnsaviv

ILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTVPKTEeqaNTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAAtAASVFESDIDCDAS
.|  |||  |  .  |.|..  .......|. ...|  ..    .   ..|  ... |        .  |||  .|. | . ..    .| . . ...|.
mltqeeergkakvhryWPskgsrsygklvvelkeevelsd...yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl.vrqvskaqqksgag

CAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. .|    | ||.| | .    .|...| .  .. ..   .|.||.. . | .|| | | . | .
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea

subfamily_PTPN14_pd Subfamily PTPN14 141-399 1.3e-14 48.9 In-house 25-295 (300) alignment
Range on Protein: 141-399
Range on HMM: 25-295/300.0
MEPEFKPIDTMKADL-EKCQAFKKNIDFSQSENVELYDTNRVKGGGEAD--F-FYHGSTLTIPSVTTK-STILAQLAIvdsPQSLESFWIMVASQKIQRL
. .|.  |  ...|   .. . ..| . .. ..|  |. |||.     .    .   |.. ..  ... | | ||  .   .. .. || ||  |..| .
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqli

FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRK----TVPKTEEQANTQLYYEVVPKDcAEAPFAMIEICDfWPDAKIPT-----MGYNRIAATAASVF
 .|  |||  |    .|||.. .. ||.. .. |     . ...  . |.|  . .|    |    ..   | ||| ..|      . | .        .
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytD.WpdhgvPeDvkgflsyLeevqsvrrkt

ESDID---CDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.| ..    .    .    |.||.|   .. | |. |. .|  .||..   .| ||   ..||.|| | | . ..|
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_PTPN1_pd Subfamily PTPN1 141-412 5.1e-12 40.1 In-house 8-282 (290) alignment
Range on Protein: 141-412
Range on HMM: 8-282/290.0
MEPEFKPIDTMKADLEKCQA-FKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVtTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILL
 .. .. |.    |..  .| ...| .  .  .|. ||  |.|   .   .   | . .. .  .| ||.|  .   |.  . || ||  || . . .| 
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleea.krsyiltqGPl...pntvdhfWqmvWeqkskavvmln

GEEELDKPTLSEYFPEDFK--EFKTIRVNNR-KTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNrIAATAASVFESDI-DCDAS
   | ..    .|.|.. .  |..   .. . | . . ...  |   .|.  . . |.   .      |||  .|    .        | ||     |  
kvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa.flkflfkvresGslssdvG

CAIV-SNYGAGRAGSFFVA---VLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYViALTYGLKHVKDPALKIK
 |..    | ||.|.| ..   .. ||| .  .. .||.  | .|..|   | |  |  |.|. |.  | | .|...   |
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl.aileGakvikgdssvqk

subfamily_PTPRB_pd Subfamily PTPRB 141-393 9.2e-10 33.0 In-house 27-278 (293) alignment
Range on Protein: 141-393
Range on HMM: 27-278/293.0
MEPEFKPIDTMKADLEKCQA-FKKNIDFSQSENVELYDTNRVKG---GGEADFFYHGSTLtIPSVTT-KSTILAQLAIvdsPQSLESFWIMVASQKIQRL
.  |.. . ... | .. .|  ..| .  . .|.  ||..|||     .|..  |  .   ||  .. .  | .|  .   |.... || ||  .| . .
fseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany.ipgynsprefiatqGPl...petvddfWrmvwekkssii

FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEAPFAMIEIcDFWPDAKIPTMGYNRIAATAASVFESDIDCDAS
 .|    |  |    ||.|.| ..     ..    . ..||. .  .    . |. .|      .    |||  .|    . .. . .   . . .....
vmltqlvekgkvkCeeYWPadeepvlyGdikvt..lvaeeeledwvirelkiekekeerkvrqyhf.tsWpdhgvPektktlldfvrtvreaiektaskr

CAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTY
  .|    | ||.| |      .....  .  .|  |  ..|..|   . | .||.| .
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifih

DSPc_SM00195 144-399 2.3e-33 111.0 In-house 5-261 (263) alignment
Range on Protein: 144-399
Range on HMM: 5-261/263.0
EFKPIDTMKAD-LEKCQAFKKNIDFSQSENVELYDTNRVKGGGE----ADFFYHGSTLTIPsVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFIL
||. ..... .   .....||| .  ...|. .|| .|||   |     . ... . ....   .|. |..|      |. .|.|| ||  .|..   .|
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivml

LGEEELDKPTLSEYFPED---FKEFKTIRVNNRKTVPKTEEQANTQLyyEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDidcD
  ||| .| . ..|.||.    ..|..|.|.....  | .|   ..|  |.  ... |. ..    .  ||| ..|  |.   ..  .. .  ..    .
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...s

ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . ...  | ||.|.| .. ....||.... ..|.||  ..|.||| ...|| ||.| | ..| |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 144-399 2.3e-33 111.0 In-house 5-261 (263) alignment
Range on Protein: 144-399
Range on HMM: 5-261/263.0
EFKPIDTMKAD-LEKCQAFKKNIDFSQSENVELYDTNRVKGGGE----ADFFYHGSTLTIPsVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFIL
||. ..... .   .....||| .  ...|. .|| .|||   |     . ... . ....   .|. |..|      |. .|.|| ||  .|..   .|
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivml

LGEEELDKPTLSEYFPED---FKEFKTIRVNNRKTVPKTEEQANTQLyyEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDidcD
  ||| .| . ..|.||.    ..|..|.|.....  | .|   ..|  |.  ... |. ..    .  ||| ..|  |.   ..  .. .  ..    .
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...s

ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . ...  | ||.|.| .. ....||.... ..|.||  ..|.||| ...|| ||.| | ..| |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 152-399 1.4e-13 45.5 In-house 31-270 (288) alignment
Range on Protein: 152-399
Range on HMM: 31-270/288.0
KADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTipSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSE
.|  .  ..| .|    . ||.   |. |||   ..||. .   ..  |   |  ..   | .     .| .| |. .. .. . .|    |. |.   |
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs..sakykrrlicaqaPl..ngtieelWkmllesdveyivmlcellekGkeksae

YFPEDFKEFKTIRVNNRKTVPKTeEQANTQLYYEVVP--KDCAEAPFAMIEICDFWPDAKIPTM--GYNRIAataaSVFesdIDCDASCAIVSNYGAGRA
|||    |   |. .   .  |  .. .  .   ..   |   |. .  |     |.|  .|     . |.      |.    ...    . |. |.||.
yfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll....evl...kslqkPivvhssaGvGrt

GSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . . ..|.| |.  .   |...  . | .|  ||.|  ||.. . . | .
gtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee

subfamily_PTPN23_pd Subfamily PTPN23 156-399 1.5e-15 51.7 In-house 35-279 (288) alignment
Range on Protein: 156-399
Range on HMM: 35-279/288.0
EKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE
  . . |.. .  .|...  || ||||  |. | .   | .   | .. . | .|      ...|  || || .|| . . .|| .|||.||  ..|.||
rsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaP...lqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

DF---KEFKTIRVNNrKTVPKTEEQANTQLYYEVVPKDCAEAPFAMieICDFWPDAKIPTM--GYNRIAATAAS-VFESDIDCDASCAIVSNYGAGRAGS
|    ..|. ..|   | | .||.  . .|  |. ..|  .    .      ||.  .|     . ..   . |   .    ...   .    | ||.| 
dkgetvkfgdlsvtl.ksvretethvervlkletldadavksvshl..qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

FFVAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . . |...|..|.  ..| ..   .| ||   ... .|. |.| . |..
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0042113 (Phosphotyrosine protein) phosphatases II 157-399 2e-31 104.7 In-house 2-242 (245) alignment
Range on Protein: 157-399
Range on HMM: 2-242/245.0
KCQAFKKNIDFSQSENVELYDTNRVKGGGEA----DFFYHGSTLTIPSVTTKsTILAQLAIVDspqSLESFWIMVASQKIQRLFILLGEEELDKPTLSEY
.......|.|. ..... .|| .|||   .     . ... |  . . .| |  |..|    .   ..| || |. ...|. .. |  ||||....  .|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqy

FP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESdiDCDASCAIVSNYGAGRAGS
.| ..........|.....     ..  |. ..||... . |  . .   .  ||| ..|  .    ..   . .. ..  | .  ... .. | ||.| 
wplgesltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGt

FFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| .| |..| |..    .. |.   .||||| |..|.|||.| | ..| .
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 157-398 7.1e-09 30.0 In-house 26-264 (283) alignment
Range on Protein: 157-398
Range on HMM: 26-264/283.0
KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPS--VTTKSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP
.... ..|  . . ...  .| .||.   |.  .   . ...       |  | ||  .    .    || ||  .||  . .|    |  .   | |.|
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld...rtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

E----DFKEFkTIRVNNRKTVPKTEEQANTqLYYE-VVPKDCAEAPFAMIEICDFWPDAKIPTM-GYNRIAATAASVFESDIDCDASCaivsnyGAGRAG
.    |. || |. ...  |      .  . | ..    .    | . .|.  .. ..| | ..  .|.. .      .. |    |       | ||..
krGsedyGef.tvtlrkettsnsfiikell.lrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCst......giGrta

SFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
 |  |. .......    .. ..   .| ||. |. || ||.. . ..| 
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

0040439 (Phosphotyrosine protein) phosphatases II 158-400 1.6e-29 98.7 In-house 5-246 (249) alignment
Range on Protein: 158-400
Range on HMM: 5-246/249.0
CQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYF
.  ...|.|  .. ..  || .|||    .|.. . ... | .. . ....  |..|      |...|.|| |.  ..|. .  |  ..||.. .  .|.
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgP...lpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSF
| ....|.....|.....     ..  |. . |.... . |    .   .  ||| ..|  .    ..   . ...|.. ...  ... .. | ||.| |
plggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtf

FVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
 .| |..| |.     ...|.   .||||| |.....||.| | ..| . 
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_CG7180_pd Subfamily CG7180 158-401 6.2e-11 36.5 In-house 36-291 (296) alignment
Range on Protein: 158-401
Range on HMM: 36-291/296.0
CQAFKKNIDFSQSENVELYDTNRV---KGGGEADFFYHGSTLtIPSVTTKSTILAQLAIVDspQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP
..  |.|..  .  .|  || |||   | .||..  |  ..  . | . |   .   | ..  .....|| .|  ..|. . .|  . .  |    .|.|
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavy.vdsflkkkeyivteapkk..etvdefWrlvydeeisavvvLtktfdfak.mypsywp

ED-FKEFKTIRVN--NRKTVPKTEeQANTQLYYEVVPKDC----AEAPFAMIEIC--DFWPD-AKIPTM--GYNRIAATAASVFESD--IDCDASCAIVS
..  .... | |.  . |. .. . . . .|. ..|         .|.  ..       |.   |.|    ..  .   . .. |     .  .   .||
nkskeqygeifveiveekqyanlk.irtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGL
. ||.|.| .. .  ..|...  |  .. | .  .| .||  .|.  .|.. | . | . |
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

0037934 (Phosphotyrosine protein) phosphatases II 159-397 1.3e-25 85.8 In-house 5-239 (243) alignment
Range on Protein: 159-397
Range on HMM: 5-239/243.0
QAFKKNIDFSQSENVELYDTNRVKGGGeaDFFYHGSTLTIPsvttKSTILAQLAIVDSPQS-LESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF
  .. |..  .  .. .|| .||| .|  . .....  ...    .  |. |.   .. .. |.||| |. ...|. .  |  ..||..    .|.|...
allpenlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev

kEFKTIRVNNRKTVPKTEeqaNTQLYYEVVPKDCAEAPFAMIEICDF-WPDAKIPT--MGYNRIAATAASVFES-----DIDCDASCAIVSNYGAGRAGS
 ......|.. ..  . .    |. .......|. . ..  | .. . ||| ..|.      ..   . .. |.      .| .  ...    | ||.| 
.tygdftvtllseehldd...ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FFVAVLAIEKLqagEaPNIKEIALSVRSQRPA-AIETLSQYMFTYVIAL
. .| | ...|   .  .. |.   .|.|||  |..|.|||.| | ..|
liaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 159-396 1.3e-11 38.7 In-house 42-275 (303) alignment
Range on Protein: 159-396
Range on HMM: 42-275/303.0
QAFKKNIDFSQSENVELYDTNRVKGGGEAdfFYHGSTLTIPsvTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE--D
. | ||.|  .  .|   |  .||    .  . | | | .   ..| .||.|| .   ...   || |.  ||.. ...|| . | ||      ||.  |
nqfvknmdknrfvdvicldhskvklsdss..yihasyleld..sskkailtqlpl...shtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

FKEF--KTIRVNNRKTVPKTEEqanTQLYYeVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAAT---AASVFESDIDCDaSCAIVSNYGAGRAGSFF
| .|  ..||| . | |  ..     .|   .   .     |  .   . || ..||. |  ..        ||.    |.      .|  | ||||.| 
flkfeersirvgefkrvelgdg...wvlkv.lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfa

VAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIA
.   |   |.. .|  ..      ||  |  |.. |||. . | . 
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 159-400 5e-09 30.5 In-house 30-270 (285) alignment
Range on Protein: 159-400
Range on HMM: 30-270/285.0
QAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK
 |.. | |. .  .|   .  ||        . | | . .|     . | .|  .   |..|  || |.  .||  ...|    |      . |.|| . 
tayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl...petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

EFK-TIRVNNRKTVPKTEEQANTQLYYEVV--PKDCAEAPFAMIEI-CDFWPDAKIPTMGYNRIAAtAASVFESDIDCDASCAIVSnYGAGRAGSFFVAV
|     . .   |  | |  | | |    |   .|..  |. |  .   .|||   |      |      | . .      |  .|  | ||. .|    
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.ykwvkkvnpkekpicvhcs.agvgrtatfvgid

LAieKLQAGEAPNIK--EIALSVRSQRPAAIETLSQYMFTYVIALTYG
 |   ..  | |||.  .|   .|. |  |...  |..| ||. . | 
ya..tirimenpniemldivremramrfqavqshmqflflyvvlmeyf

0045098 (Phosphotyrosine protein) phosphatases II 160-401 3.5e-20 68.0 In-house 29-273 (278) alignment
Range on Protein: 160-401
Range on HMM: 29-273/278.0
AFKKNIDFSQSENVELYDTNRVKgggeaDfFYHGSTLTIPsvtTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-K
 . .|.|.    ..  || .|||     | . . | ....   .|  |..|      |. ...|| |. ...|. .  | ...||..    .|.||.  .
lylgnldknRykdilpydhsrVk.....d.YINAsyidgy...pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl

EFKTIRVNNRKTVPKtEEQANTQLYYEVVPKDCAEAPFAMIEICD--FWPDAKIPTMGYNRIAATAASVFESDID--------------CDASCAIVSNY
... ..|.. ..    ..   . |... .    .. . . ... .  .|||  .|.. . .    .    .. ..               .  ...  ..
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GAGRAGSFFVAVLAIEKLqaGEAPNIKEIALSVRSQRPA-AIETLSQYMFTYVIALTYGL
| ||.| . .| | .| |  ..  .. |.   .|||||  |...|.||.| |  .| . |
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 160-399 1.2e-16 55.6 In-house 37-275 (281) alignment
Range on Protein: 160-399
Range on HMM: 37-275/281.0
AFKKNIDFSQSENVELYDTNRVKGG---GEADFFYHgSTLTIPSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED
  ..|.   .  |.  ||  |||      . .  |      .|... .   .|  . |  |.||..|| || .||.. . ..  | | .|     |.|.|
kadenvlknrYsnivaYDatrvkvtpneenkntDYi.nanfvpgykgekeyiatqgPv..PaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

FKEFKTIRVNNRkTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICdFWPDAKIPTMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLA
 .| |   |  . .. ..|..   .  ...  ... .   . ..    |||  .|.   . .   ..    .. . .|.  |    | ||.|..     .
nselkygdvtvk.staeeekatyierkfkleresgetreveqlayt.aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl

IEKLQ-AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.....   |  ..|..  ..| .|   . |. || | | . | .
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 160-395 7.9e-07 23.5 In-house 44-283 (325) alignment
Range on Protein: 160-395
Range on HMM: 44-283/325.0
AFKKNIDFSQSENVELYDTNRV-----KGGGEADFfYHGStlTIPSVTTKSTILAqlAIVDSPQSLESFWIMVASQKiQRLFILLGEEELDKPTLSEYFP
.  .|..  . .||  .| .||     |  ...|. .  |   . .   | . ||  | .  ..... .| .|   .   . ..| | .|.|   . |.|
mkpenkaknrfknvvaldksrvvletkkddpssdy.inas..ylrddkkkdvfla..aqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywp

ED---FKEFKTIRVNNRkTVPKTEEQANTQLYYEVVPKdcAEAPFAMIEICDFWPDA---KIPTMgYNRIAATAASVFESDID-CDASCAIV--SNYGAG
..    |.| ...|. | |. .  .    .|    | |   |.          |.|    | |.     |  .   | |     . ||  |.     | |
kemgksktfGglevklr.tieeisdyvhrvldvkqvkk..GetrsvkqfqlqswddmGvqkrpat.lisilqlvkavservtantkastpilvhcsaGvG

RAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
|.| |     |..|.      .| .    .| .||. .||  ||.. |  
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea

subfamily_PTPN3_pd Subfamily PTPN3 162-392 1.7e-11 38.5 In-house 39-267 (280) alignment
Range on Protein: 162-392
Range on HMM: 39-267/280.0
KKNIDFSQSENVELYDTNRVKGGGEA-DFFYHG-STLTIPSVTTK-STILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK
 .|..  .  ..  ||. |||   .  |.       . ||| ..    | .|  .   ... . || ||  ||.. . .|    |  .    .|.||  .
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPl...aktatdfWqmvweqksslivmlttlverGrvkChqyWPeted

EFKTIrvnNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIaATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLA
|..     . . . . |.. .. .. |.| || ..    .|    .  ||| ..|.   . .     .| .     .    .    | ||.| . .  .|
eleyg...efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadfl.efvervrklrsgkeePvvvhCsaGigrtGvlilleta

IEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFT
. ...| |. .. .|   .| || . ..| ||| | 
lalieaaepvypldivrtmrdqramlvqtasqykfv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 162-399 3.8e-08 27.8 In-house 47-283 (297) alignment
Range on Protein: 162-399
Range on HMM: 47-283/297.0
KKNIDFS--QSENVELYDTNRVKGGG-----EADFFYhGStlTIPSVTTkSTILAQlaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP
.|...|.  . .|.  ||..|||        ..|..   |   ....     |  |      ..... || ||  .... . .|  ..| ||     |..
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvn.as..fvkgnkh.rlittq...mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

ED-FKEFKTIRVNNRkTVPKTEEQANTQLyyEVVPKDCAEApfAMIEICDF--WPDAKIPTMGYNRIAATAASVFESDIDCDAS-CAIV-SNYGAGRAGS
..  ..| .. |    .| . |   . .|  ||   .       ...  .|  ||| ...     .      |  . | .  |.   .|    | ||.| 
dkgvttfGdvsvvll.svsereGfikrel..evtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

FFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.      . . .  .. .| ..   .| .||  . |  || | ||. | .
lltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 163-406 9.6e-11 35.9 In-house 54-295 (305) alignment
Range on Protein: 163-406
Range on HMM: 54-295/305.0
KNIDFSQSENVELYDTNRVKGGGEAD-FFYHGSTLTIPSVTTKSTILAQLAIvDspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFK
 .|   . ..|   | . ||    .   . |   .  | .  |  | ||  . |  |... || ||  .|.... .|    || |   ..|.|    | .
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpl.d..qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

TIR----VNNRKTVPKTEEQANTQLYYEVVPK-DCAEAPFAMIEICDfWPDAKIPTMGYNRIAATAAsVFESDIDCDASCAIvsnyGAGRAGSFFVAVLA
...    |.|       | .|. |.    .      .     .. .. |||  .|      .   .| .  | .     |.     | ||.|.       
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwte.wpdrgvppckltslellsa.irgskvpivvhcsa....gigrtgtivaieyi

IEKLQ-AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKD
.||.    ..| . |.  ..| ||  .|..  ||.| . . | | |.. |.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke

0041856 (Phosphotyrosine protein) phosphatases II 164-399 1.1e-10 36.9 In-house 1-170 (182) alignment
Range on Protein: 164-399
Range on HMM: 1-170/182.0
NIDFSQSENVELYDTNRvkgggeadffyhgstltipsvtTKSTILAQLAIVDSPQ------------SLESFWIMVASQKIQRLFILLgeeeldkptLSE
|.|    ...  || .|                        . |.| | . . |.            ....|. |. ...|. .  |             
nldknrysdilpydhsr......................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eel

YFPEDFkefktirvnnrktvpkteeqantqlyyevvpkdcaeAPFAMIEICDFWPDAKIPTmgYNRIAATAASVFEsdidCDASCAIVSNYGAGRAGSFF
|.||..                                        .  .. .|||  .|.   . . .    | |     .  ...  ..| ||.|.. 
ywpell....................................erlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlv

VAVLAIEKlqageAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.| | ...       .. |.   |||.|| ...|..|| | . ..| .
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 166-399 4.4e-11 37.2 In-house 46-276 (315) alignment
Range on Protein: 166-399
Range on HMM: 46-276/315.0
DFSQSENVELYDTNRVKG-----GGEADFFyhGsTLTIPSVTTKSTILAQLaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE---DF
   . .|.  .|..|||        . |..    .  |.|| .  . .|       . |.. || ||  .|.  . ..   .| ||     |.|.   | 
kknryknilPldsarvkleviddsPdsdyi..n.asyiksvdddkayiasq..gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

KEFKTIRVNNRKTVPKTEEQAnTQLyyeVVPKDCAEAPFAMIEICDfWPDAKIPTMGYnRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAI
 || .|.|.  .. . |.  |  .|   |. |  .    .  .  . |||  ..      .      |  ..   . |  .    |.||.| .  .   .
vefGsikvellsleadtdgva.rkl...vtrkseesrtvtqfqfte.wPdkGvdkqts.sllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

EKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.... ... .. ..   .|..||  . |  .| | | . | .
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled

Y_phosphatase Protein-tyrosine phosphatase 167-397 1.9e-38 127.6 Pfam-A 4-234 (235) alignment
Range on Protein: 167-397
Range on HMM: 4-234/235.0
FSQSENVELYDTNRVKG---GGEADfFYHGSTLTIPSvTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEF
  .....  || .|||    .|. | ... ....  . ..|. |..|      ....|.|| ||  .|.. ...|  .|| .. ....|.|   |.....
knRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

KTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEA-PFA-MIEICDFWPDAKIPtMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIE
..|.|...  . ..|......|.   . |...|  ..  .   .  ||| ..|   .. .  .  .| .|  ...... ...  |.||.|.| .. ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
.|.|.| .....|  ..|.||| ....|.||.| | . |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 167-397 1.9e-38 127.6 In-house 4-234 (235) alignment
Range on Protein: 167-397
Range on HMM: 4-234/235.0
FSQSENVELYDTNRVKG---GGEADfFYHGSTLTIPSvTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEF
  .....  || .|||    .|. | ... ....  . ..|. |..|      ....|.|| ||  .|.. ...|  .|| .. ....|.|   |.....
knRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

KTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEA-PFA-MIEICDFWPDAKIPtMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIE
..|.|...  . ..|......|.   . |...|  ..  .   .  ||| ..|   .. .  .  .| .|  ...... ...  |.||.|.| .. ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
.|.|.| .....|  ..|.||| ....|.||.| | . |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 170-399 3.5e-08 27.0 In-house 49-275 (515) alignment
Range on Protein: 170-399
Range on HMM: 49-275/515.0
SENVELYDTNRVKG-----GGEADFFYhGStlTIPSVTTKSTILAQLaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE---DFKEFK
 .|.  ||..|||        . |.|   |   |||. .  . .|       . |.. || .|  ...  . ..   .| ||   ..|.|.   |  .| 
yknilPydsvrvklevindnPhsdyfn.as..yipsfdndkayiasq..gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

TIRVNNRKTVPKTEEQAnTQLyyEVVPKDCaEAPFAMIEICDfWPDAKIPTMgYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ
.|.|.   .   |.     .|  .|.  |      .  .  . |||  .|    . .      |  .      .  |    |.||.| .  .   . . .
sikvelvsleactggik.rkl..tvlkgdd.srtvtqfhfte.WPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahak

AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 ... .. ..   .| .||  . |  || | | . | .
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 170-394 4.1e-07 24.4 In-house 9-233 (237) alignment
Range on Protein: 170-394
Range on HMM: 9-233/237.0
SENVELYDTNRV--KGGGEADFFYHGSTLTIPSVTTKSTILAQLAIVDspqSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDfKEFKTIRVNn
  |.  || .||  || | .  .   . |     | |. | ||  .     | . || ||  .|   . .| |  | ..    .|.|.  .. ..  |  
ygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgples...scddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvl.

RKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIAATAASVFESDIDCDASCAIVSN-YGAGRAGSFFVAVLAIEKLQAGE
  .. | || ..  .   .. |        .|   .|  |||  .|      .      . .|    ...  |.    | ||.| |.|    . . .  .
tvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk

APNIKEIALSVRSQRPAAIETLSQYMFTYV
  .| .   |.  .||  |.|  ||.| . 
vvdiynyvysieedrpyiiqtkdqyvfihq

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 204-400 1.6e-21 70.3 In-house 115-309 (346) alignment
Range on Protein: 204-400
Range on HMM: 115-309/346.0
KSTILAQLAIVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED--FKEFKTIRVNNRKTVPKTEEQANTqlyYEVVPKDCAEAPFAMIEI
.  |.|||  ...   .| || |.  ..|. ..... .. | . | | .  |.  ..    . .|||..    . .  |    ||.|.  ...  . .  
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeyt...ievlpegnsdsvicqvhh

CDFWPDAKIPTMGYNRIAATAASVFESDIDCdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
   |   . |      |        | ..   |   .|| .|.||| ||  |. ||..|. |  ||| ||  ... ||| ..|...||   | | . | 
hapwkhlqqppktlpiikmihqflsekqvqn.agvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 204-399 3.4e-18 60.7 In-house 52-241 (250) alignment
Range on Protein: 204-399
Range on HMM: 52-241/250.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPtLSEYFP-EDFKEFKTIRVNNRKTvpktEEQANTQLYYEVVPKDCAEAPFAMIEI-
|. | .|  ..   ...| || ||  .|.. . .|   .| .|   ..|.| |  ...  ..|.  ..    || |. .    .. |   .    . .. 
kafiatqgPlq...atiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllsk....eefadytkrklklskakkaderivrqlh

CDFWPDAKIPTMgYNRIAATAASVFESDIDCDASCAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
   |||  .| . .. . .    |  |.  ....  ||    | ||.|.| .    .|.|.  .  .. ..   .| .|| |.|.|.||.| | |.| .
fvvWPdkgvPev.atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 204-396 9.2e-08 26.5 In-house 51-236 (239) alignment
Range on Protein: 204-396
Range on HMM: 51-236/239.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVvpkDCAEAPFAMIEICD
|. | .| ..     |   || |.  ..   . .| |  |  |    .|.|.   ..  .||  |||   ..    | .  .|     .|  .       
kayiatqgcve...issgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhft

FWPDAKIPTMGYNRIAaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
 |||  .|      .      . .  .       |  . | ||.|.|.|    . . .  .. .| .   ..| .||  ..|  ||.| ..  
vwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 204-396 1e-07 26.4 In-house 52-237 (239) alignment
Range on Protein: 204-396
Range on HMM: 52-237/239.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVvpkDCAEAPFAMIEICD
|. | .| ..     |   || |.  ..   . .| |  |  |    .|.|.   ..  .||  |||   ..    | .  .|     .|  .       
kayiatqgcve...issgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhft

FWPDAKIPTMGYNRIAaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
 |||  .|      .      . .  .       |  . | ||.|.|.|    . . .  .. .| .   ..| .||  ..|  ||.| ..  
vwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

0043147 (Phosphotyrosine protein) phosphatases II 207-393 8.7e-10 34.1 In-house 22-154 (172) alignment
Range on Protein: 207-393
Range on HMM: 22-154/172.0
ILAQLAIvdSPQSLESFWIMVASQKIQRLFILLGEeeldkptlseyfpedfkefktirvnnrKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWP
..| ..    .  |..|| |. ...|. .. | ..                            . |. .|. . |..|  .|  ..  .  ..|...|  
fiatqgp..lrntladfwrmlkelgithivnltel...........................lydpellerlgiqylylpwpDhgvpllellleflefid

D--AKIPtmgynriaataasvfesdidcDASCAIVSNYGAGRAGSFFVAVLAIeklQ-AgeapNIKEIALSVRSQRPAAIETLSQYMFTY
.  |. |                     .  ...   .| ||.| . .| | .   .      .. |.   ||..|| |... |||.| |
ellalsp.....................ggpvlVHCsaGvgRtgtlvaaylml...lgl....sleeavalvrekRpgavqnpsqyrfly

0036282 (Phosphotyrosine protein) phosphatases II 209-393 8.7e-11 37.3 In-house 17-163 (174) alignment
Range on Protein: 209-393
Range on HMM: 17-163/174.0
AQLAIVDSPQSlesFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEdfkefktirvnnrktVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDA
  | . . | .   || |. ...|. .. || |.||..     |.||                .. .|. . |..|  .| ...     ..|...|  .|
prliagqgpla...fwemlkelgittvvmlleekelglykcinywpe...............lredlerlgiqylylpwpDhgvpdlsillefvkfveea

KiptmgynriaataasvfeSDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQaGEAPNIKEIALSVRSQRPAAIETLSQYMFTY
                   |. | .  ...  . | ||.| . .| | .  |    . .. ..  ..|.||| ...| |||.| |
l..................se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

0046846 (Phosphotyrosine protein) phosphatases II 211-395 2.9e-11 38.9 In-house 19-168 (176) alignment
Range on Protein: 211-395
Range on HMM: 19-168/176.0
LAIVDS--------PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEdFKEFKTirvnnrktvpkteeqantqlyyevvpkdcaeapfamIEIC
|.. .         |..|..|. |. ...|. .. |. | ||..  .  |.|| .....                                       ..
lilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................................qylh

DFWPDAKIPTMgynRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEklqaGEAPNIKEIALSVRSQRP-AAIETLSQYMFTYVI
  |||  .|..   ..  ..    .. .. .   ..    | ||.| . .| | .     .   .. |.   ||.|||  |..| .|| | |  
lpwpDhgvpdl...elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyef

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 213-399 3e-07 24.7 In-house 90-277 (287) alignment
Range on Protein: 213-399
Range on HMM: 90-277/287.0
IVDSP--QSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF----KEFKtIRVNNRKtvpKTEEQANTQLYYEVVPKDCAEAPFAMIEICDfWP
| .||  . .  || ..  .... . .|  |.| |.    .|.||.      |.. |.. |..   ....  . .|  .   |. ..      .| . |.
iaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyn.iellnee...vnagyierklevknknkagdkqqvkqyqitn.Wd

DAK-IPTmgYNRIAATAASVFES-DIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.   ...  .. |       . .     ..|  .    . ||.. |  |  .|.| .   . .. ..  | | |.| .. | .||.| . | |.|
stgkvte..pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

0044763 (Phosphotyrosine protein) phosphatases II 214-391 8e-08 27.6 In-house 33-162 (178) alignment
Range on Protein: 214-391
Range on HMM: 33-162/178.0
VDSPQslESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKefktirvnnrktvpkteeqantqlyyevvpkdcaeapfaMIEICDFWPDAKIPTm
 . |.  .... ..  ..|. .  | .| || .. . .|.||..                                        .  ..  .|| . |. 
gslpp..addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDhgvpd.

gYNRIAATAASVFESDI-DCDASCAIVSNYGAGRAGSFFVAVLAIEKlqageAPNIKEIALSVRSQRPaAIETLSQYMF
   ..   .    |. . ...  ...  ..| ||.|.. .| | ..        .. |.   ||..|| .... .|. .
.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq

0051082 (Phosphotyrosine protein) phosphatases II 215-394 1.6e-06 23.4 In-house 19-147 (151) alignment
Range on Protein: 215-394
Range on HMM: 19-147/151.0
DSPqsLESFWIMVASQKIQRLFILLGEEELDkpTLSEYFPEDFKEFKTIRVNNRKTVPkteeqantqlyyevvpkdcaeapfamieicdfwpdakiptmg
. |  |. |. ......|.  . | .||| .  .. ||.||   |.. | . . .. .                                          
ggp..ladflellkelgiktivnlrseeerg..ycpeylpelgievlhipildwpdpg..........................................

YNRIAATAASVFESDIDC-DASCAIVSNYGAGRAGSFFVAVLAIEKlqageaPNIKEIALSVRSQRPAAIETLSQYMFTYV
   . .......|  .|. .  ...  . | || | . ...| ...       .. |.   .|..|| .. .  |..| . 
lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_PTPN12_pd Subfamily PTPN12 216-399 1.2e-11 39.0 In-house 92-276 (290) alignment
Range on Protein: 216-399
Range on HMM: 92-276/290.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKE---FKTIRVNNRKTVPKTEEQANTQLYYEVVpkdCAEAPFAMIEiCDFWPDAKIPT
 |. |. || |. ..... . ..  | ||.|     |.||  .|   | ...|.. .    ...    .|  |.     ..  .  ..    |||  .|.
LpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfh.YtaWPDhgvPs

MgYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAP---NIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
   ... .  ..| |   . ||  ..    | ||.|   .  .. | |.|.  |   .. .. |..| ||.|.. |  || . |   . .
s.aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 216-399 3.2e-10 34.5 In-house 73-263 (270) alignment
Range on Protein: 216-399
Range on HMM: 73-263/270.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGY
 | .|.||| |. ..| . . .. | ||  .   . |.|.. ||  ...  . |..  .||...  .  ..  .. .|    .      |||  .|..  
lpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreed

-----NRIAATAASVFESDIDCDAS-CAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
     . . .. . | .|  . | .   .|    | ||.| . .   |.. |.  .  .. .|   .| .|.| ...  || | |   ..|
sslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 216-396 5.1e-10 33.8 In-house 101-275 (315) alignment
Range on Protein: 216-396
Range on HMM: 101-275/315.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQlyyEVVPKDCAEAPFAMIeiCDFWPDAKIPTMGY
 ..|.. || .|  ..| .. .| .  | .|    .|.|..   .  | |  ..   .||    |     || .|  .  . .      |||...|    
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlh..ytswpdmgvpkyti

NRI--AATAASVFESDIdcdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
. .    |.    ....   ..  .  . | ||.|.|      .....| .| .. ..   ||..|  ..... || | | . 
plmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 216-404 6.8e-09 30.6 In-house 77-262 (284) alignment
Range on Protein: 216-404
Range on HMM: 77-262/284.0
SPQSLESFWIMVASQKIQRLFILLgeeeldKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEqanTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTM
 . .|. || |.  ...  . .|       |   |.|.| . .. .     . ..| ..||     .    . .|  |     |    |  |||   | .
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdy

GYNRIAATAA-SVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT---YGLKHV
. . ..     . ..|  .  |.  .    |.||.| . |    .....  .  .. ..   .| ||.  .. | ||.| |.  |    .|   |
psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 216-401 9.3e-09 30.0 In-house 113-295 (319) alignment
Range on Protein: 216-401
Range on HMM: 113-295/319.0
SPQSLESFWIMVASQKIQRLFILLgeeeldKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEqanTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTM
 . .|. || |.  ...  . .|       |   |.|.| . .. .     . ..| .|.|     .    . .|  |     |    |  |||   |  
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdy

GYNRIAATAA-SVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT---YGL
. . .      . ..|  .  |.  .    |.||.| . |    .....  .  .. ..   .| ||.  .. | ||.| |.  |    .| 
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh

subfamily_PTPRG_pd Subfamily PTPRG 216-394 1.3e-08 28.5 In-house 100-281 (563) alignment
Range on Protein: 216-394
Range on HMM: 100-281/563.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-KEFKTIRVNNRKT---VPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP
... .. || |.  |. . . ..   .|  .     |.|.|  .......|.  ..   .  |...   .       |.| .    .   .  |||   |
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

TMGYNRIAATAASvfESDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYV
.     .     |  .     .|   .|  ..|.||.| . |    ....|. .| |. ...  .|.||.  ..|  ||.| . 
ehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 217-399 2.4e-19 64.7 In-house 109-289 (298) alignment
Range on Protein: 217-399
Range on HMM: 109-289/298.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE-DFKEFKTIRVnnrkTVPKTEEQANTQLYYEVVPKDC--AEAPFAMIEICdFWPDAKIPTM
....| || ||  ..|. . .|   ||||| . ..|.|.   ... .|.|    .. ..||.|.       | |     |    ...    |||  .|..
tetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv....sllskeefadlivrklkvskkkeekerevrqlhft.sWpdkgvpen

GyNRIAATAASVFESDIDCD-ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
  . . .  . |  |  ..  ..  .    | ||.|.| .    .|.... .   . ..   .| .||.|..| .||.| | . | .
a.tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_PTPRD_pd Subfamily PTPRD 217-421 4.4e-17 56.9 In-house 101-305 (564) alignment
Range on Protein: 217-421
Range on HMM: 101-305/564.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTvpktEEQANTQLYYEVVpKDCAEAPFAMIEICDF--WPDAKIPTM
....| || ||  |...   .|   || .|  ...|.||.  ...  . |.  ..    || |. ..    . |.  .    ...   |  |||  .|. 
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleee....eeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpes

GyNRIAATAASVFESDiDCDASCAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY---GLKHVKDPAL
. . . .    | ..   .|| . .|  . | || | | |    .|.... .  .| ..   .|.||.| ..| .||.| . . | .   | ..|.  .|
a.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl

KIKTEKVISQLE
| ...|. .. |
kqhlqkLaevee

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 217-399 6.7e-13 43.3 In-house 83-267 (274) alignment
Range on Protein: 217-399
Range on HMM: 83-267/274.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKE-----FKTIRVNNRKTVPKTEEQAnTQLY--YEVVPKDcaeapfAMIEICDFWPDAK
|. .. || |.  ...| . .|   .| ..   ..|||.. .      .. . ....|.| . . .  ..|.  |   ...       .      ||| |
pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysv.rklvlkylerers......vkhywytdWPdhk

IPTMgYNRIAATAASVFESDIDCDASCA---IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 |    | .  . . | ||  . .| .|   .    | ||.| |  . .|. .|.. .  .. .|   .| .|   ..| .|| . . .   |
sPdd.antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly

subfamily_PTPRK_pd Subfamily PTPRK 217-398 4.8e-10 33.7 In-house 96-275 (314) alignment
Range on Protein: 217-398
Range on HMM: 96-275/314.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTqlyYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMG
.. .. || .|  ..   . .|    |  .   ..|.||| . .. |.|.  .| ...|  . .   . |     .   . ..   .|  ||| ..|.  
qetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvri...frveklargqeeirevrqfqflgWpdhdvPvsa

YNrIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
   . .  . | .|. . .    .    ||||.| | .    .. ..  .  .. ... ..||...  .||  ||.| | ..| 
tg.llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

0049260 (Phosphotyrosine protein) phosphatases II 217-393 1.8e-09 33.0 In-house 19-143 (152) alignment
Range on Protein: 217-393
Range on HMM: 19-143/152.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFpedfkefktirvnnrktvpkteeqantqlyyevvpkdcaeapfamIEICDFWPDAKIPTMGYN
|..|..|| |. ...|. .  |  ..||.|.   .|.                                               .. .|||   |..   
pntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdlsql

RIAATAASVFEsDIDCDASCAIVSNYGAGRAGSFFVAVLAIeklqagEAPNIKEIALSVRSQRPAAIETLSQYMFTY
 . .  .  .   .| .  ...   .| ||.| . .| | .         ...|.   ||..|| |... .|..| |
llflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_PTPN9_pd Subfamily PTPN9 217-402 4.8e-09 30.7 In-house 95-292 (297) alignment
Range on Protein: 217-402
Range on HMM: 95-292/297.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEFKTIRVNNRKTVPKTEeQANTQLYYEVV-PKDCAE-APFAMIEicdfWPDAKIP
..  . || ||  |..  . .    .|  .   ..|.|   |. .||  ..|.| ... . .    ..|  . |  ..  .   | ..     |||  .|
kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleiknvkteesrkvthfqfls....WPdyGvP

TMGYNRI-----AATAASVFESDI------DCDASC-AIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
  . . .     .  . ... ...      ...     .    | ||.| |    .....|.  .  .. |    .|.||  .| |  ||.| |.  | |
ssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

GLK
 |.
ale

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 217-399 1e-08 29.4 In-house 101-282 (290) alignment
Range on Protein: 217-399
Range on HMM: 101-282/290.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNrktvpKTEEQ--ANTQLYYEVVPKDCAeAPFAMIEICDFwpdAKIPTM
.. |  || ..  .|.  . .|. . | .| .   |.|.   |..  ....        ||.    ..   ||  |. | ..  ..    .     ..  
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl.....lneetlneyierklevknknsa.gakqsvtqyqi...tnwdst

GYNRIAATAASVFESDI-----DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
|     .|  .|.|  .     . . |  .    . ||.. | .|  .|.| .     .. ..  | |.|.|  ..|  || . . | |||
gkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_PTPN6_pd Subfamily PTPN6 217-399 2.2e-07 25.1 In-house 108-296 (306) alignment
Range on Protein: 217-399
Range on HMM: 108-296/306.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKT--IRVNNRKTvPKTEEQANTQLYYEvvPKDCAEAPFAMIEI-CDFWPDAKIPTM
.. .. || ||  .. . . ..  | |  |   . |.|.  .. ..  |.|.| .   ....    .|  .   |. ..    ...     |||. .|. 
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvs..kkkkkkeerevfqyhfksWPdhgvpkd

GYNRIaATAASVFESDID---CDASCAIV-SNYGAGRAGSFFVAVLAIE---KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 .  . .    | .   .    .|   .|  . | || |.| |  . ..   |       .|...  |||.||   . | .|| | | .  .|
pgavL.dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 217-397 3.2e-07 24.2 In-house 101-276 (439) alignment
Range on Protein: 217-397
Range on HMM: 101-276/439.0
PQSLESFWIMVASQKIQRLFILLGEEELDKptlseYFPEDFKEF---KTIRVNNRKTVPKTEEQAntqlYYEVVPKDCAEAPFAMIEIC-DFWPDAKIPT
 .. ..|| .|  .|  ..  |    |  |     |.| | . .    ..||.    .|.   .     .  .  .| .|   .....    ||| ..|.
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirg....fkvfnerdttekertvlqfhyiawpdknvpa

MGYNRIAATAASvfESDIDCDASCA--IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
     .    |   .|  | .      .    | ||.|.     .|.|.|.. .  .|| |   .| ||   ...| ||.| |   |
qashvldflrai..nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_PTPRA_pd Subfamily PTPRA 218-404 4.5e-15 50.3 In-house 112-302 (330) alignment
Range on Protein: 218-404
Range on HMM: 112-302/330.0
QSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTVpKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMG
...| || |.  || . . .|   .| ..     |.|..    .  |||. ....  ... .  ..  . .|. . | .  ...   |  |||  .|. .
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

YNRIAATAASVFESDIDCDaSCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLK---HV
   .   ..     .  .. .  .    |.||.|.| |    .|...| .  .. |.  ..| |||  . |. || | | . | | |     .
iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel

0051429 (Phosphotyrosine protein) phosphatases II 218-399 3.5e-10 35.5 In-house 33-224 (272) alignment
Range on Protein: 218-399
Range on HMM: 33-224/272.0
QSLESFWIMvASQKIQRLFILLGEEELDKPTLSEYFP-------------EDFKEFKTIRVNNRKTVpkTEEQANTQLYYEVVPKDCAEAPFAMIEICDF
 . ..|| . ....|   . | .|||...   . | |             . . ..  .|| . ...  . .      .. .   .  ||.  |.  .  
ltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee..llldyilrellltlllsagearevmhlhytd

WPDAKIPTMGYNRIAATAASvfesdidcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPN--------IKEIALSVRSQRPAAIETLSQYMFTYVIA
|||  .|.  . .. .  ..        .  . .  . | .| | . ...| .. . .    .        . |.   .|.|||.|..|  ||.| | ..
wpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

LTY
| .
lel

0049772 (Phosphotyrosine protein) phosphatases II 218-398 2.2e-07 26.4 In-house 155-278 (314) alignment
Range on Protein: 218-398
Range on HMM: 155-278/314.0
QslesfwimvasqkiqrlfillgeeeldkptlSEYFPEDFKEFKtirvnnrktvpkteeqantqlyyEVV--PKDCAEAPFAMIEIcdFWPDAKIPTMGY
.                               .|. ..|....|                       |..  |... .. .  . |   .||   |.  .
g...............................neptaadlellk.......................eelydpelferlgikylri..pvpDgsaplled

nrIAATAASVFESdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLqaGEapNIKEIALSVRSQRP-----AAIETLSQYMFTYVIALT
  . .  . . |   | .   ..  . | ||.|.| || . . .|  |   ...|.   ||..||      .||.| || | . . | 
..fdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 219-402 2e-06 21.7 In-house 93-271 (281) alignment
Range on Protein: 219-402
Range on HMM: 93-271/281.0
SLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK---EFKTIRVNN-RKTVPKTEEQANTQLYYEvvpkdcAEAPFAMIEICDFWPDAKIPTMG
.   || |.  ..   . .|    | ..   .|||| . .   .|  . |.    || |.   .  .| ||       |. .    .   ||| ..|   
tradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye......getrlithwlwkewpdwqvpess

YNRIaataaSVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRS-QRPAAIETLSQYMFTYVIALTYGLK
   .      ..       .   |    | ||.|...   .|.. ...    |.||.|   .|   | |...|| |||. . . | .|. 
evml.....kilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 265-396 1.6e-08 28.5 In-house 196-332 (347) alignment
Range on Protein: 265-396
Range on HMM: 196-332/347.0
VNNRK-TVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAATAASVFESD------IDCDASCAIVSNYGAGRAGSFFVAVLAI
.| |. .| .   .   .   ||| . |.|| || .  |  ||  | |    . .|   | | ||       ..  |   .. . |  |. .  .. . |
intravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiii

EKLQAGEAPNIKEIALSVRSQRpAAIETLSQYmFTYVIA
|.. .| .|.  ..   .| || | . |.| . .|| | 
eqvldgktpdcddlfkkmrdqr.agvftmsif.ytyair

PTPc_DSPc_SM00012 304-396 6.5e-16 53.8 In-house 9-103 (105) alignment
Range on Protein: 304-396
Range on HMM: 9-103/105.0
FWPDAKIPTMGyNRIAATAASVFESDIDCD--ASCAIVSNYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
 ||| ..|. . . |  . ..| ..  ...  ... ...  |.||.| | .. .....|... . ..|..|  ..|.||| ...|. ||.| | . 
gwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral

0048076 (Phosphotyrosine protein) phosphatases II 304-395 7.4e-06 21.2 In-house 54-138 (145) alignment
Range on Protein: 304-395
Range on HMM: 54-138/145.0
FWPDAKIPTMGynRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEklqagEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
 |||  .|..   ..  ..    |. .. .  ...  . | ||.|.. .| | ..     .  .. |.   |||||| |... .|. | |  
pwpDhgvpdll..ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyef

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 338-395 3.5e-07 24.5 In-house 197-254 (267) alignment
Range on Protein: 338-395
Range on HMM: 197-254/267.0
IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
.  . | ||.|.|.|.   .|...  .  .| .  . .||||.. ..|. .|.. . .
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 339-398 9e-08 26.3 In-house 234-293 (297) alignment
Range on Protein: 339-398
Range on HMM: 234-293/297.0
VSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
    | ||.|    .   ..||. .  |... |   .|.||.  ..|| |. . | ..| 
hcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_CG42327_pd Subfamily CG42327 341-400 4.8e-06 20.5 In-house 255-315 (319) alignment
Range on Protein: 341-400
Range on HMM: 255-315/319.0
NYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
  |.||.|    . .||..|.   .. .| ..  ||| .|  |. |  || | | ..  | 
sdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya