Gene F47B3.6 in Caenorhabditis elegans

Synonym: CELE_F47B3.6, F47B3.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP091_AA protein Get Run
CeleP091_AA_5-279 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2-306 4e-195 641.7 In-house 1-306 (307) alignment 
Range on Protein: 2-306
Range on HMM: 1-306/307.0
IVVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWA
.|||||||||||.||||||||||||||.||||.|.|||||||||||||||.|||||||||||.|||||||||||||.|..|||||||||||||||.||||
svvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwa

MAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVANLGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAIN
||||||||.|||||..||..||||.||||||.||||||||||||||||||||||.||||..||||||||||.|.|||||||||||||||||||.||||||
maiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltain

LLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAEL-LVGDYGEKYKK
||.|.|...||..||||||.||.||||||..|||||.||.||..|..|..||||.|...||.|.||||||||||.||||.|||||.|| |. .| ||| |
lleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekyak

WADDYA
| ||| 
wlddyn
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 3-292 4.2e-106 349.0 In-house 10-303 (305) alignment 
Range on Protein: 3-292
Range on HMM: 10-303/305.0
VVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANT------DKNRYQDVPCQDKGRIVVKFPGlASDYIHANYLGTATNP-KKFICAQGPLENT
.|. .|.|.||.||. | .||| |||.|   ||  || ||        |||||||||||.  . .. |   ||||||||.|    | |.||||||||..|
iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqt

QHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGeapNTISVANL-GAKKMAPDeQCINVTTLKVDW-GQGSRTIQHLQWENWPDRGVP
   || | ||.||| ..|||. .|.||.|| ||||. ||.|| .    . | | |. |.| |  |   |..|.|.. . |. . ...|||| .|||||||
idefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk...sgivvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewpdrgvp

QTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAELLVG
  .||...|||| || . ||.|||||||||||||||| |. .|.    .|  | ||.| || .| .||||. |||..|||.| ||||.||| || ||  
pckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaallta
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 3-283 8.5e-58 190.7 In-house 5-276 (288) alignment 
Range on Protein: 3-283
Range on HMM: 5-276/288.0
VVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMtTEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAM
|.  |... |...|..|  |.|   . ... .  ..| ||. ..||...|. |  |. ..    .  ||.|| . .| .....|||| ||. |   .| |
vinawirlvlqiaveglkkeyrdspneasidi.idsfianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

AIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApntisvANLGAKKMAPDEQCINVTTLKVDWG-QGSRTIQHLQWENWPDRGVPQTNLTAIN
 ... || ..|||. .| || |  .|.|...|.|  .|         .   || |  .. ..|..|..    . .  ...| . .|.| |||.  |. ..
llesdveyivmlcellekGkeksaeyfPsklGekarigrl......ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr

LLSATRGNQNPILVHCSAGIGRTGTIVAIaYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYK
||   .  |.||.||.|||.|||||.. |  .  ...  .. .....|...|| .|  .|| | ||||.||..| ..| .  
llevlkslqkPivvhssaGvGrtgtlili.lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 4-299 3.5e-45 149.1 In-house 6-297 (312) alignment 
Range on Protein: 4-299
Range on HMM: 6-297/312.0
VKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTeAFSANTDKNRYQDVPCQDKGRIVVkfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMA
.| |    .    | |  |.. . .  ..   | ||    | ||| .. | |.||. .   |    |||||..   |.|..|.|.|||||||   || .|
ikkwasavmmstpqqltkeykavgnivsdsect.aflkfkdlnrypniqcwdrgrftl..agdenfyihanfvkictkperfvctqgplentcthfwqla

IQEKVECVIMLCNCIETGKIKCHQYWPL-----EQGQKLVFGEAPNTISVANLGAKKMApdEQCINVTtLKvDWGQGSRtIQHLQWENWPDRGVPQTNLT
.     ..|.||  .| |  || .|        .  .. |. |    | .      |..   . ..|  .|   || |. ..| ||  ||| |.|..  |
lslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkit..hrvlkvv.vk.atgqesk.lnhyqwaswpdhgmpdscdt

AINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAELLVGDYGEKY
|  |||| . ...|.. |||||.|||||.. |  .   .        . .    ||  |  |..   ||.|  |..| ..  .      |     . | |
alrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfkety

K
 
a
0040438 (Phosphotyrosine protein) phosphatases II 6-284 4e-78 258.2 In-house 7-282 (317) alignment 
Range on Protein: 6-284
Range on HMM: 7-282/317.0
PWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGL--ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMA
..... | ....|| .||. | . ... ... .. .| ||||| |... |  |.... .|    ||||.|.|  .   ..|||..||||.|| ..|| | 
lalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

IQEKVECVIMLCNCIETGKIKCHQYWPLeqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAIN
 ...|....||... | |..||.|||||  |..|..|.    ..| .|. ..    .. |...||.|    .. |||..|... .||| |||..  . ..
weqgvtvivmLteleelgrekcaqYwpl..getltygd....ftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

LLSATRGN----QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKE
.|.| | .    ..|.|||||||.|||||..|. .. . .  .. .. . | .||||..|| ..|.. || .|...|| |.. ... 
fleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 7-281 9.6e-76 249.4 In-house 12-290 (305) alignment 
Range on Protein: 7-281
Range on HMM: 12-290/305.0
WVQRTLDMGVQALVDEFRVLAKWTP-EGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQ
.|.|||. | . |  ||  . ..   | | .   . ...||||.|| | |. |. .. .    .||||||. | ||||.|||.| |||.|   || | .|
fvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkle.gpwpheyihanyvstptnpkrfictqaplektcadfwymclq

EKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVANLGAKKMAPD---EQCINVTTLKVD-WGQGSRTIQHLQWENWPDRGVPQTNLTAIN
.||| ..|||| .| |  ||..|.. .....| | |  . |||    ....      .  .. | | ..  |. .| ..|  | .||||||| ..|. ..
dkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlaile

LLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
||  .|  . || |||||||||||..| . |. |...||.     . ... .|  |  ||| . |||..|.|.| ||...
llekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 7-281 3.7e-54 178.7 In-house 11-282 (288) alignment 
Range on Protein: 7-281
Range on HMM: 11-282/288.0
WVQRTLDMGVQALVDEFRVLAKWTPEGMTTEA-FSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMA
.|...  .. . ...|...||.   .  .| .  . | .||||...   |  |. .|    .  .||| |.|.    . ||.|..|||| .| . || . 
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

IQEKVECVIMLCNCIETGKIKCHQYWPLEQgQKLVFGEapntISVANLGAKKMapdEQCINVtTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLL
 ..|.. ..|| . .| || ||..||| .. ..  .|.    . |  .. |..   |. ..  .| ..  .. ..|...|.  ||| |||. .   ..||
yenktstivmltelveggktkCeeYWPdad.kpknyGs....vtvtlveskel...edfvlr.klllekkkteleitqyqylaWpdhgvPeskapllell

SA----TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.        ...||.||||||.||||| .|.  . |.. . |. . . . ...|| .|.  .|.. || ....||||   |.
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
0051299 (Phosphotyrosine protein) phosphatases II 8-278 2.8e-73 242.2 In-house 14-286 (288) alignment 
Range on Protein: 8-278
Range on HMM: 14-286/288.0
VQRTLDMGVQALVDEFRVLAKWT-PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
|...|  |.  | .||. | ... .  ... .. .| .||||.|... |. |.... ..    ||||.|.|. .  ...|||..||||.|| ..|| |  
vlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvw

QEKVECVIMLCNCIETGKIKCHQYWPLeqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD------WGQGSRTIQHLQWENWPDRGVPQTNLT
...|....||....| |..||.|||||  |..|..|.    |.| .|  ..    .. . |.||.|       ... |||..|... |||| |||..   
eqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

AINLLSATRGN----QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 ...| . |      ..|..||||||.|||||..|. .. . . .. ... . |..| ||..|| ..|.. ||......|| |.
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPN9_pd Subfamily PTPN9 8-280 1.7e-56 186.4 In-house 7-292 (297) alignment 
Range on Protein: 8-280
Range on HMM: 7-292/297.0
VQRTLDMGVQALVDEFRVLAKWTPEGMTTE-AFSANTDKNRYQDVPCQDKGRIVVKF-PG-LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
|.   ..| . |. |.  . . ..||  .     ||  ||||.|| | |. |.|..  ..  |||||.||..    ..| || .||||..| . || |  
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

QEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEapntISVANLGAKKMApDEQCINVTTLKVdWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
...|  ..|   ..|.|..|| ||||||...   ||.    .||.|.  ...  | .   ..  .|   . ||.. | |   ||| |||..  . ...|.
eqevlvivmttrvvergrlkcgqyWpleeessaefgd....lsvsnveveeee.dykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvle

ATRGNQ-----------------NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
. | .|                  ||.|||||||||||| ... .  ...   .. . . | .| ||. | .||| . || . .  .| | ||
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 8-286 8.2e-51 167.9 In-house 11-288 (318) alignment 
Range on Protein: 8-286
Range on HMM: 11-288/318.0
VQRTLDMGVQALVDEFRVLAKWTPEGMT-TEAFSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
|.|    |   |  |.  |.. . .  .     ..|  ||||...   |. |. ..       |||| |||.   .. |..| ||.|| .| . || |  
vrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

QEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLvfgeapNTISVANLGAKKMapDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
. .   ..|| .. | ||.|.|.||| .. ...      ... |     ...  ..  .   ... .  . ||...  .. .|||.|||.   . ..|. 
eqnsavivmltqeeergkakvhryWPskgsrsy......gklvvelkeevel..sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvr

ATRGNQ-----NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETY
 ..  |     .||.||||||.||||. .|.  . ... | |. . . . .|.||..|.  .| | || ... ||| .     .|. 
qvskaqqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 8-279 1.3e-24 81.4 In-house 13-280 (303) alignment 
Range on Protein: 8-279
Range on HMM: 13-280/303.0
VQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfpglASDYIHANYLGTATNpKKFICAQGPLENTQHSFWAMAIQEK
 .||||   .  |.||  .. . |  .. . |  | ||||. || | |. .. .      | ||||.||   .. || | .| ||  |   || | |..|
akrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls....dssyihasyleldss.kkailtqlplshtaadfwqmiieqk

VECVIMLCNCIETGKIKCHQYWPLEQgQKLVFGEapNTISVANLGAKKMapdEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQT----NLTAI-NL
| ||..|    |  |.  .  .| .| . | | |   .| | ..   ..    .  ..  | |  |.    ..  ....||   .|       .  | .|
vkcvlllltdseydklggdsvfprnq.dflkfee..rsirvgefkrvel...gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwql

LSATR--GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
 |  |   . .| .    .| ||.||.  .   .  . . .... .   .. .|  |  ..||  |. ... .|  . |
qsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 9-278 9.4e-52 170.5 In-house 19-290 (310) alignment 
Range on Protein: 9-278
Range on HMM: 19-290/310.0
QRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFP-GLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEK
  |  .|.. || ..| |       .| ||.  .  |||| || |.|. |. .|       |||||||. |    . |||.||||. |   || | .||.
iateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqer

VECVIMLCNCIETGKIKCHQYWPLEQ-----G--QKLVFGEAPNTISVANLgAKKMAPDEQCINVTTLKVDwgqgSRTIQHLQWENWPDRGVPQTNLTAI
 | ...||.  | |. ||  |||        |  .   ..|. . . . || |  . ||.  ..    ...       .. ..| ||||||||. .  ..
aesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnl.avtfvpdnvpvdeqpanlk....elrvslikwpnwpdrgvpdekchtv

NLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
     ..  . | .||||||..|....||. .  ||.  |.. . ..|.. ||. .|   ||.|.|||...|| . . 
pqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglk.vdaeevktellksraiciqtelqyliidrvriifa
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 10-278 1.7e-53 176.7 In-house 16-283 (319) alignment 
Range on Protein: 10-278
Range on HMM: 16-283/319.0
RTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVV-KFPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEK
.  . | . |  ||. | . ... ...     | .|||||..   |. |.|. ...|   |||| |... .  . .||| .|.||||| . || |  .|.
alastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

VECVIMLCNCIETGKIKCHQYWPLEQgqKLVFGEAPNTISVANlGAKKMAPDEQCINVTTLKVDWgqgsRTIQHLQWENWPDRGVPQTNLTAINLLSAT-
. .|.||..  | .|.|...||| |.    ..|.   |.   .   ...   . ..|  . .|.     |...| |...||| .||.. .. ..||    
ssivvmltklveklkvklkkywpeen..feeyGrlivtleeee.eledyiirklklnkkssevet....RevkhfqyteWpdhdvPekatslldllkrir

----RGNQNPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
    . .. || ||||||.||||| ...  . ...   |. . . . ...||  |.  .|.. || ... .|| . 
ksrektqsgPivvhCsaGvGRtGtfivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
0043336 (Phosphotyrosine protein) phosphatases II 11-278 4.7e-70 231.5 In-house 14-277 (278) alignment 
Range on Protein: 11-278
Range on HMM: 14-277/278.0
TLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA--SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKV
 |  . ..|  ||  | . ... ... .. .| ||||| |... |  |....  |    ||||.|.|. .   |.|||..||||..| . || |  ...|
lllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

ECVIMLCNCIETGKIKCHQYWPleqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT
....||... | |..||.||||   |. |..|.    ..| .|. ..    .. . |.||.|       |||..|... .||| ||| .  . ...| | 
ttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

RG----NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
|     ...|.|||||||.|||||..|. .. . .. .  .. . | .||||..||...|.. || .|...|| |.
realedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 12-281 4.9e-74 244.8 In-house 27-292 (297) alignment 
Range on Protein: 12-281
Range on HMM: 27-292/297.0
LDMGVQALVDEFRVLAKWTPEgMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG---LASDYIHANYLGTATN-PKKFICAQGPLENTQHSFWAMAIQEK
  .. . |  ||  | . .|. ... .. .| |||||.|... |  |...| ..   | ||||.|.|. .    ..|||..||||..| ..|| |  ...
kansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqg

VECVIMLCNCIETGKiKCHQYWPLEQGqklVFGEapntISVANLGAKKmapdEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR
|....||....| |. ||.|||| |.|   ..|.    ..| .|. ..    .. ..|.||.|  .. |||..|.|. .||| |||..  . ...| . |
vtvivmLtklvelgr.kcaqywpeegg...tygd....ftvtllkveh....ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvr

G------NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
       ...|.|||||||.|||||..|. .. . .  .  .. . | .||||..||...|.. || .|...|| ... .
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 12-277 9.1e-61 200.0 In-house 22-282 (290) alignment 
Range on Protein: 12-277
Range on HMM: 22-282/290.0
LDMGVQALVDEFR-VLAKWTPE-GMTTEAFSANT--DKNRYQDVPCQDKGRIVVKfPGLASDYIHANYLGTaTNPkKFICAQGPLENTQHSFWAMAIQEK
 ...|. |  |.   |  . |   .  . | .||   ||||.||.|.|| |...|  |   ||.||||.   ...  || .||.|..|   .| | .|||
vkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk.dGydGdyvhanyvkG.lka.mfiltqGalkdtvidiwrmvlqek

VECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANlgakKMAPDEQCI--NVTTLKVDWGQgSRTIQHLQWENWPDRGVPQTNLTAINLLSA
|  ..|||. || || ||.||.| ..|. | |||   |.  ..    .  .|.. |   ..  ..| |. .  ..||.   |||. |....|. . .| .
vaaivmlceliedGkakceqyypekeGevltfGei..tvlcse....eddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlri

TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
 |    |. ||||||||||||.|||    . .. | . . . .|.. ||  |  |.| . ||| | ..|| .
lrkasGpvvvhcsaGiGrtGtfvaievglqilldGke.ldlldlvralrnsrlnsvqvdiqylalveilldl
0045450 (Phosphotyrosine protein) phosphatases II 14-280 9.9e-75 247.4 In-house 24-306 (307) alignment 
Range on Protein: 14-280
Range on HMM: 24-306/307.0
MGVQALVDEFRVLAKWTP---EGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGL---ASDYIHANYL--------GTATNPKKFICAQGPLENTQHSF
 ... |  ||. | . |.     ... .. .| |||||.|... |  |.... ..     ||||.|.|         ..  ...|||..||||..| ..|
dfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD---WGQGSRTIQHLQWENWPDRGVPQTN
| |  ...|....||....| |..||.||||.| |..|..|.    . | .|. ..    .. . |.||.|      . |||..|... .||| |||.. 
wrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

LTAINLLSATRG------NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENC--MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
 ...... . |       ...|.|||||||.|||||..|. .. . . ... .  . . | .|.||..||...||. || .|...|| ..|.
eelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 14-288 1.7e-41 136.8 In-house 8-278 (281) alignment 
Range on Protein: 14-288
Range on HMM: 8-278/281.0
MGVQALVDEFRVLAKWTPEGMTTE-AFSANTDKNRYQDVPCQDKGRIVVKF--PGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVE
| .. . .||  |    |  . |      |  |||| ..|| |  |. .|.  |   ..|||||||. .    . .| .||| ..|.  || |  ||.  
mtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentt

CVIMLCNCIETGKIKCHQYWPLEQGQKLVFgeapNTISVANlgakKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN
...|||. .|| . || .|.| .    | |    . .||.     . .  .. .  | |.. .   .| | |  |..|||  ||..    ...|   |  
aivmlcqfletnrekcaeyfprnahcclqf....dklsvsy....edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar

QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRS-HRPWSIQNEFQYLYLHRVLLSYFLeRYKETYAE
  | ..|||||.||.||..|.    . . .      .....  ||   |  |.|   ||. . .||| . .  ||.   |
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv.aykqitee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 14-280 5.5e-41 135.9 In-house 31-293 (319) alignment 
Range on Protein: 14-280
Range on HMM: 31-293/319.0
MGVQALVDEFRVLAKWTPEGM--TTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVE
  .. |  ||| ..| ....   |      | ||||. ..   || .. ..   |   |||| | ..    ...|.| |||||.||   || |  . .. 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

CVIMLCncietgKIKCHQYWPLEQGQKlvfgEAPNTISVANLGAKKMapdeQCINVTTLKV-DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA---
 ...|       | || |||||.  .|    |    ..|  .   .       .    |      .. | |.   .  ||| |||.     . |.     
tivllt......kdkcsqywplkivik....eerfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrh

---TRGNQNPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
      ....|.||||||.||||. ...  . | .|  |. . . .....||  |.  .|.  || ...  ||  .| 
ltskenhranivvhcsaGvGrtGvyivldvlld.rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_PTPRD_pd Subfamily PTPRD 15-280 4.8e-60 198.8 In-house 21-283 (564) alignment 
Range on Protein: 15-280
Range on HMM: 21-283/564.0
GVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVV-KFPG-LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVI
. . .  |.. . . . . ... . .||  ||||...   |. |.|  |..|   |||| |... . ...|..| .||||..| . || |  ........
sdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiV

MLCNCIETGKIKCHQYWPLEqGqKLVFGEapntISVANLGAKKMApDEQcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR----G
|| .. | || |||.||| . | .  .||    . |     ...| | . |   .||    . ||.... .. .|||.|||..  . ..|..  |     
mltkleEkgkvkchkYWPek.g.tetyge....ltVtleeeeela.dye.irtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnep

NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
.. ||.||||||.||||| ..| .. ... . |. . . . .|.||..|.  .|.| || ..|...| .   
dagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 15-278 1.4e-58 193.3 In-house 13-276 (281) alignment 
Range on Protein: 15-278
Range on HMM: 13-276/281.0
GVQALVDEFRVLAKWTPEGMTTEAF-SANTDKNRYQDVPCQDKGRIVV--KFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECV
  . .. |.. ||.   .  .| ..  .|. ||||...   |..|..|  .     .||| ||.. . ...|..| .|||. .. ..|| | ...||. .
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

IMLCNCIETGKIKCHQYWPlEQGQklvfgeapnTISVANLGAKKMAPDEQCINV-TTLKV-DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT---
.|. . ||.||.|||.||| .. .         .......  |..|  |.   .  ..|.   .  .|....|.. .||| |||.|    ..  ..    
vmvtreieagklkChrYWP.ddns.........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

-RG-NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 .  .. |...|||||.||||| .|.  . ... | .. . ......||| .| . .|   || ......| ..
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 15-278 5.7e-52 171.8 In-house 25-290 (298) alignment 
Range on Protein: 15-278
Range on HMM: 25-290/298.0
GVQALVDEFRVLAKWTP----EGMTTEAFSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKV
..  . .||. | . .     | ..    ..| .||||.|.   |. |.|..       |||| | .| .... . || .|.||..| . || | ..|..
kltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi

ECVIMLCNCIETGKIKCHQYWPLEQGQKlvFGEapntISVaNLGAKKMAPDEQCINVTTLKvDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG
....|| |  |..|.|.|.||| |. ..  .||    |.| .| .|.   |  . ...  |    ...|....|.. .|||.|||... . ..||.  | 
gtiVmltnleeldktkyhkywPdegket..yge....itv.sllskeefadlivrklkvsk.kkeekerevrqlhftsWpdkgvpenatsvldllrkvra

NQ-----NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
.|     .|..|.||||.||.|| .||  | ... . |. . . . .| || .|| ..| | || ... . | ..
sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 15-278 1.4e-44 147.2 In-house 18-278 (287) alignment 
Range on Protein: 15-278
Range on HMM: 18-278/287.0
GVQALVDEFRVLAK--WTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVI
| .   . | || .   ... .| .  | | ||||....  .|. |...|  |   ||| | .. .  . |.|| |..|. ||   || .  ...|. ..
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaiv

MLCNCIETGKIKCHQYWPLEQGqkLVFGEApnTISVANLGaKKMAPDEQCINVTTLKVDwgQGSRTIQHLQWENWPDRG---VPQTNLTAINLLSAT--R
|||.  |. . .|.|||| |.   .|.||   .|.. |   ..    |. ..|.  . .  .  ....  |  ||...|    ||| |  |.    |  .
mlcqekendeevcyqyWpeeks..vvlGey..niellnee.vnagyierklevknknka..gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk

GNQNPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
  . .|.||||...||... .|.|   .|    |  . . ...|. |  .| |.|   || ..  ..| | 
rgntsivvhCsdtvGrsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 17-277 1.9e-52 173.3 In-house 22-282 (305) alignment 
Range on Protein: 17-277
Range on HMM: 22-282/305.0
QALVDEFRVLAKWtPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG-LA-SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
..|  ... |..  .| .  .  .||. |||....  .|. || ..    |  |||| |.|. .  . ||.| |||||.|| . || . ..|||. ..||
kgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivml

CNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANlgaKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----
.. .| || ||.|||| ....|  |||   .. . .   .| |.|    ...  . |  . |||. ..|  .||| ||||.  . ..|.   . .|    
tklveggkdkCrqYWpesktekkefgef..svelks...ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

-NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
  |.|||||||.||||. .|.    ... . |. . . |..|.|||.|.  .|.  || .|| .|  .
gvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN13_pd Subfamily PTPN13 17-276 2.9e-51 169.3 In-house 11-267 (273) alignment 
Range on Protein: 17-276
Range on HMM: 11-267/273.0
QALVDEFRVLAKWTPEGMTTEAFS-ANTDKNRYQDVPCQDKGRIVVKFPGLasdYIHANYLGTATN--PKKFICAQGPLENTQHSFWAMAIQEKVECVIM
|   .||. | .  |   .... . .|.|||||..|   |. |. ..  |    || |...    .    ..| .|||| .| . || |  . |.| ..|
qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LCNCIETGKIKCHQYWPLEQGQKLVfgeAPNTISVANLGAKKMapDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN---Q
. .  |.||.|||.||| ....||.   . | . |..|. .|.  |.  ..  ..|    . || ..||.. .||| |||.. .  .....  |     .
vtlekekgkvkchrywPesknkklk...vsnrlevellkvqkl..dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

NPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
 ||.|||||||||.||...|  | . ... .. . ..|....||  |   .| . ||.. ....| 
gPivvhcsaGiGrsGtlitidvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
0047943 (Phosphotyrosine protein) phosphatases II 18-278 6.7e-72 237.5 In-house 13-272 (273) alignment 
Range on Protein: 18-278
Range on HMM: 13-272/273.0
ALVDEFRVLAKWTPEGM-TTEAFSANTDKNRYQDVPCQDKGRIVVkfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCN
 |  ||. | ...|..  .. .. .| |||||.|... |. |...  ..  ||||.|.|. .   ..|||..||||.|| ..|| |  ...|....||..
llleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLte

CIETGKIKCHQYWPLEQGQ-KLVFGEapntISVANLGAKKmapdEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG-----
..| |..||.||||||.|. .|..|.    ..| .|. ..    .... |.||.. .   . |||..|... .||| |||..    .... . |      
lvelgrekcaqYwpleggelsltygk....ftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 ...|..||||||.|||||..|. .. | . .. ... . |..| |||.|| ..|.. ||..|...|| |.
psngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 18-275 1.3e-51 170.2 In-house 16-272 (280) alignment 
Range on Protein: 18-275
Range on HMM: 16-272/280.0
ALVDEFRVLAKWTPEGMTTEA-FSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNP----KKFICAQGPLENTQHSFWAMAIQEKVECVI
|.. .|  | .  |.  ...|  ..| .||||.|.   |. |. .|     .||| |||.    .     ...| .||||..| . || |  ..|.. ..
avlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk..esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLCNCIETGKIKCHQYWPLeQGQKLVFGeaPNTISVANLgakkMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLL---SATR-G
|| . .| |..|||||||  ....| .|    .. . .      .  . ..   .||    . .|.| .||. .||| |||. .   ....    ..| |
mlttlverGrvkChqyWPe.tedeleyg..efsvkceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg

NQNPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
...|..||||||||||| ....      ..  .. . . ......|  |   .|.. || ..   .|
keePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 18-279 3.1e-41 136.6 In-house 24-289 (325) alignment 
Range on Protein: 18-279
Range on HMM: 24-289/325.0
ALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKvECVIMLC
..  || .|    .  ... .  .| .|||...|   || |.|..  .    |||| |.|| .  . . |. || || .| . .| .... .   |... 
gfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvl

NCIETGKIKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMapDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA----------
| ...|| .| .||| | |.   ||    .. |    ....   .    |  .|   .  .|... .|.  |.| ||..   | |..|            
neldlgkdrcavywpkemgksktfG....glevklrtieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
      |||||||||.||||. ...  . .|..  |  . . . .| || .||  ..   ||  ..  |  ...
ntkastpilvhcsaGvGrtGvfislysalakvie.esrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_ptpA1_pd Subfamily ptpA1 18-234 8.1e-33 108.8 In-house 22-253 (418) alignment 
Range on Protein: 18-234
Range on HMM: 22-253/418.0
ALVDEFRVLAKWTPEGMTTEA-FSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTAtNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
 . .|||.| .      |.|     || |||| ..   .. |. .|       |||| |||.  |  ||.|||.|||| ||   || |  ....  ..||
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivml

CNCIETGKIKCHQYWPLEQG--QKLVFGEAPNTISVANLGAKKMAP-DEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ-
    |  .||| .||| . |  |  ..|.  . .   ..   ..    |. |    ... .   .| | . |.| |||. .|.      .|| .    | 
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

---------NPILVHCSAGIGRTGTIVAIAYVQ
          ||.||||||.|||||...   . 
qiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 18-284 1.7e-23 77.5 In-house 27-291 (302) alignment 
Range on Protein: 18-284
Range on HMM: 27-291/302.0
ALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRivVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQ---HSFWAMAIQEKVECVIML
 . .||  ...   .    .|| .|..||. .|||. |. .  || .. . .|..|  .      .. | || |  ...    .|| |. |||.  | .|
evkkefkkidtmkvdlekCkafkknlkknqsedvpildsnl..vkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

CNCIETGKiKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMAPDEQCINVTTLKVDWGQgSRTIQHLQWENWPDRGVPQTNLTAI----NL-LSATRGN
    |  |   ....|...|. . .|    .. | |   .|.  ...   .  |  .  . |  ..    .||..  ||.   ..|    ..  . . ..
vgeeelkk.tlselfpkksgdykeyg....kmfvNnrkVekaeeektryviEvlPegcsn.svlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

QNpILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKE
.| ...    |.|| |.... | . .|. .| .   ..|..| .|| || ....  ||  |...|| |.... ..
en.tvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
0046845 (Phosphotyrosine protein) phosphatases II 19-281 8.8e-74 243.7 In-house 2-277 (284) alignment 
Range on Protein: 19-281
Range on HMM: 2-277/284.0
LVDEFRVLAKWTPE---GMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA---SDYIHANYLGTA-----TNPKKFICAQGPLENTQHSFWAMAIQEK
| .||. | ..|.     ... .. .| .||||.|... |. |...| ..     ||||.|.|. .       ..||||..||||.|| ..|| |  ...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VECVIMLCNCIETGKIKCHQYWPLEqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVDW---GQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
|....||....| |..||.|||||| |..|..|.    ..| .|  ..    .... |.||.. .   .. |||..|... .|||.|||..    ...| 
vrvIVmltelvengrekcaqYwple.gevltygd....ftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

ATRGN------QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEN--CMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
. |        ..||.||||||.|||||..|. .. . . ...   .. . |..| ||..|| ..|.. ||......|| |.. .
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Ptp69D_pd Subfamily Ptp69D 19-278 2.5e-49 163.0 In-house 24-286 (307) alignment 
Range on Protein: 19-278
Range on HMM: 24-286/307.0
LVDEFRVLA-KWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLC
|. |.. |  . ..   .. .   |. ||||.|.   || |...|  .|   |||| |... .  . ||||.||.|.|.| . || |  . .|. ..|| 
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

NCIETGKIKCHQYWPLEqgQKLVFGeapnTISVANLGAKKMA-PDEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT----RG
|  |. . ||..||| |  ..  .|     | |     .|.    .. ..|.. | .    . || .   .. .|.|  ||..  . ..|..      . 
nlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
|. ||.|||||| ||.|..||.. . ... | |... . | .|.|||.|.  .|.  || .|.| || | 
nrsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_egg_pd Subfamily egg 19-305 6.2e-41 135.0 In-house 16-291 (307) alignment 
Range on Protein: 19-305
Range on HMM: 16-291/307.0
LVDEFRVLAKWTPEGMTTEAFSAN-TDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLC
|   . || . . |   |.|.|.|  .| | . |.|.|  |. ....    . |.||||..       .||.|| || ||.. || |  ||.|. ..|| 
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlt

NCIETgkIKCHQYWPLEQGQKLVFgeAPNTISVANLGAKKmAPDeQCINVTTLKVdWG--QGSRTIQHLQWEnWPDRGvpqTNLTAINLLSATRGNQNPI
   |.   .|. |||  . . ||.   | .. . ||. .. ..|    .|| ||.  |  .  | ..| |.. .   .      . ...|   |   .|.
srkes..erceyywpkaesdslvt..vpGslrienlkvds.kad.plfrvtklkl.vGgddeerflehwqgd.vnnss...dvysplrvlrklrnlskpv

LVHCSAGIGRTGTIVAIAYVQDKMMAGENC-MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYkETYAELLVgDygekYKKWADDY
.|..  |. ...|.|||     ... |      . . .. || .|. |..  ..||...|..| .| .    .  || | |    |..| ...
vvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi.gsakeldv.d....yerwleer
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 19-280 3.9e-36 119.7 In-house 28-286 (297) alignment 
Range on Protein: 19-280
Range on HMM: 28-286/297.0
LVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA--SDYIHANYLGTATNpkKFICAQGPLENTQHSFWAMAIQEKVECVIMLCN
  .||. | . .    |.     | .|.||...   |. |. ..  .    |||. | .. .  .  ..|. | | ..|   |||| ..|.|  ..|| .
fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnd

CIETGKiKCHQYWPlEQGQKLvFGEapntISVANLGAKKMA-PDEQCINVTTLKvdwGQGSRTIQHLQWENWPDRGVPQ--TNLTAINLLSATR----GN
  |. | || .||. ..| .  ||.    .||  |  ..     .. ..||  |    .  | ..  |. .|||. |..  .  . ..|.|  |    .|
dnerdk.kcaryWs.dkgvtt.fGd....vsvvllsvsereGfikrelevtkgk...akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqn

-QNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
 ..|.||||.||.|||| ...|  |  ..   |. . . .|.| || .||  .| . || ... ..| ..| 
aegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 19-278 7.6e-36 118.3 In-house 17-293 (301) alignment 
Range on Protein: 19-278
Range on HMM: 17-293/301.0
LVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG----LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
. .... | . ... .| .  ..|.  ||....   |. ||..|          .|| |.|.   .. |||| ||||...|   || . .|||.  ..|.
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

CNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVAN---------LGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGV---PQTNLTAIN-
.|  |. | ||.||||  . ..  ||.  .|..  .         |  |     ..     ..||.  . |...  ||  .||. ||   |.| | .|. 
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

-LLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 .    . .  |..||||....|.|. ...    .   | |    . ...| .|  .|  ..   ||  .. |.  |.
vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 19-127 7.1e-09 29.6 In-house 13-129 (347) alignment 
Range on Protein: 19-127
Range on HMM: 13-129/347.0
LVDEF-RVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfPGL--------ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVE
|   |   ||...|  .|.  .  . .||| .||  .|. |.|.  |          .  || | ..      |..| .| || .|   || |    || 
lstyfdenlanyspskftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvt

CVIMLCNCIETGKIKCHQ
 |. . . |.   |.  .
qvvtifepikdeaieefa
0045098 (Phosphotyrosine protein) phosphatases II 20-280 5.5e-69 227.9 In-house 11-274 (278) alignment 
Range on Protein: 20-280
Range on HMM: 11-274/278.0
VDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVvkfpglasDYIHANYLGTAtnPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIE
 . ...|.   |  .|.  .  | ||||| |... |  |..        |||.|.|. .   |||||..||||..| ..|| |  ........||....|
lefefllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelve

TGKIKCHQYWPlEqGQKLVFGEapntISVANLGAKKMapDEQCINVTTLKVD----WGQGSRTIQHLQWENWPDRGVPQTN-----LTAINLLSATRG--
 |..||.|||| | |. |..|.    ..| .|  . .  |. .. . ..        .  ||...||.. .||| ||| ..     | ... . . .   
lgrekcaqywp.e.ggsltygd....ftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

------------NQNPILVHCSAGIGRTGTIVAIAYVQDKMmagENCMAMNELIKELRSHRPW-SIQNEFQYLYLHRVLLSYFLE
            ...|.|||||||.|||||.||. .. . .   |. . . | .|||||.||  ..||. || .|...|| ..| 
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 20-279 1.3e-46 153.8 In-house 23-284 (290) alignment 
Range on Protein: 20-279
Range on HMM: 23-284/290.0
VDEFRVLAKWTPE-GMTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL---ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
 ..| .| .   |  .|..  | |  .||....  .|  ||...  .|    . .||.| |.    . |..| .|||..||   || .  |||| ...||
rnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivml

CNCIETGKIKCHQYWPLEqGQKLvFGEApnTISVANLGAKKmAPDEQCINVTTLKVDwgQGSRTIQHLQWENWPDRG---VPQTNLTAINLLSAT--RGN
.| || || ||.|||| . ..|  .||   .| . |  . .    |. ..|.  . .  . .......|  ||.. |    ||| |..|.    |  .  
tniieegkvkCqqYWpds.dtka.ygef..sikllneetln.eyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

QNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
...|.||||...||... .|.|   .|.   |  . . ...|..|. .| |.| . || ......|.|. 
ntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPRN_pd Subfamily PTPRN 20-269 7.2e-29 95.4 In-house 32-283 (297) alignment 
Range on Protein: 20-269
Range on HMM: 32-283/297.0
VDEFRVLAKWTPEGMTTEA--FSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLgTATNPK--KFICAQGPLENTQHSFWAMAIQEKVECVIM
  |.  |...  |  |.|.     | .|||...|   |. |. .|       |||| |  . . ..|.   .| .|||| .|  .|| |  .. |  ...
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.ldhdprapayiatqgplastvadfwqmvweqGvvvivn

LCNCIETGKIKCHQYWPlEQGQKLVfgeapnTISVANLGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLL----SATRGN
|..  |.|  .|..||| ..|...        |   .| ....  |.  .    ||    . .||.  . .  ||..||| .  . ...      . || 
ltrleeegvkqckrywp.deGsevy......hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLY
  ||.||||.| ||||. ..|  | .... | . . .   .. ||  ||  .. . |. .
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef
subfamily_PTPRG_pd Subfamily PTPRG 21-287 5.5e-47 155.2 In-house 23-296 (563) alignment 
Range on Protein: 21-287
Range on HMM: 23-296/563.0
DEFR-VLAKWTPEGMTTEAF--SANTDKNRYQDVPCQDKGRIVV-KFPGLAS--DYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
 ||  .  . ... ...|.     |  |||| ..   |. |. . . ||  .  ||| |||.      |.|| .||||..| . || |  ...|. ..|.
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmi

CNCIETGKIKCHQYWPLEQGQKLvfgeapNTISVANLGAKKM-APDEQCINVTTLKVDWGQG---SRTIQHLQWENWPDRGVPQTNLTAINLLS----AT
 |  | |. ||..||| .. ...      ....|     ...  . .. . .  ||.. ..     ..... .. .||| |||. .|  ..       |.
tnlvergrrkcdvYWPkdesety......galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

RGNQNPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYA
. .  ||.||||||.||||| ...  .  ..   || . . ...| .|..|.  .|.| ||..|| .||.  . . .|  |
kaeaGPivvHcsaGvgrtGtyivldtllkqi.qqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 21-281 1.9e-44 146.8 In-house 23-280 (315) alignment 
Range on Protein: 21-281
Range on HMM: 23-280/315.0
DEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVV--KFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCI
.||. |    .   ..   . |  ||||...   |. |...        |||| | |. .  . | .|..||||. .   || | .||||  ..|. .  
eefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkq

ETGKIKCHQYWPLEQGQKLVFGeapnTISVANLGAKkmaPDEQCINvTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN----QNPIL
|  |||| |||| ....   ||    .|.|. |  .   .| . ..   | .  .. |||.   |...|||.||..   . ..|. . ...    . ..|
egdkikcrqywPdrkadsvefG....sikvellsle...adtdgva.rklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsll

VHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
||||||.|||| ...|  | ...   .. . . ...|.||..||  .| | .| ... ..| ..| |
vhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 21-276 2.4e-35 116.8 In-house 24-277 (439) alignment 
Range on Protein: 21-276
Range on HMM: 24-277/439.0
DEFRVLAKWTPE---GMTTEAFSANTDKNRYQDVPCQDKGRIVV-KFPGLA-SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLC
..|  .    |.     .  | . .  ||||.||   | .|... . ||.  | || |||.    ..| .| .||| ..| ..|| . |..|.  ..||.
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt

NCIETGKikchqYWPLEQgqKLVFGEAPNTISvANLGAKKMApdEQCINVTTlKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT-----RGNQ
| .|. |     ||| ..  . ..|.    .   |.   . .   . ..|   . | ..  ||. ....  |||. ||      ...| |      . . 
nlvesyk.....ywpsda..evcygdiavrvd.rnielpnyv..irgfkvfn.erdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

NPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
 |..||||||.||||||.|.    ...   || . .. ..| || .|   .|.  ||....  .| 
gpvvvhcsagvGrtGtiialdialeql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 21-281 1.4e-30 101.0 In-house 24-239 (392) alignment 
Range on Protein: 21-281
Range on HMM: 24-239/392.0
DEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCI
.||. |        |.     |  ||||...   |. |....       |||. | |. .  | | .|..|||   . . || |  ||.|  ..|. .  
eefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

ETGkikchqywpleqgqklvfgeapntisvanlgakkmapdeqcinvttlkvdWGQGSRTIQHLQWENWPDRGVPQTN---LTAINLLSATRGNQN-PIL
|                                                     |.  ||.   .. .|||..||.     |  |. ..|  |.   |..
egd..................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpli

VHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.|||||.|||| ...|  |  .       . . ... ..| .||. .| . || ...  .|  .| |
ihcsagvgrtgvvisidsvvahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygavledllwr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-282 1.6e-27 91.2 In-house 10-263 (267) alignment 
Range on Protein: 21-282
Range on HMM: 10-263/267.0
DEFRVLAKWTPEGMT--TEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNcI
 ||  . | ...  |  .   . | ..||..|.   |. |....      .|| | |. .    ..||  |.||.||.  |. . ...||  ...| . .
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr..tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk.v

ETGKIKchQYWPLEQGQKLVFGEapntISVANlGAKKMAPDEQCINVTtLKVDWgQGSRTIQHLQWENWPDRGVPQTNLTA---INLLSATRGNQNPILV
 |..|.  ..|| . ||   . .    ..|     .|   | | | .  ||.   . .. .    ...|      .  |     |         ..|..|
ftdnir..lfwPPkmgqakkyqd....ltveh.slekeendyqiitle.lkfkn.esahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

HCSAGIGRTGTIVAIaYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERY
.||.|.||.|| . | . | . .  |. . . ......|| |.  ..   .|.|.|..|  |   | 
acsdGvGrsGtflvi.dsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
subfamily_PTPRB_pd Subfamily PTPRB 22-281 1.6e-59 196.4 In-house 30-288 (293) alignment 
Range on Protein: 22-281
Range on HMM: 30-288/293.0
EFRVLAKWT-PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVK--FPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCI
|.  | .    . ...   ..|..||||...   |. |. ..       |||| |||.   . |..|| .|||| .| . || |  ..|.. ..|| ...
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlv

ETGKIKCHQYWPLEQgQKLVFGEapntISVANLGAKKMapdeQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ------NP
| ||.||..||| .. .  ..|.    |.|  .  ...    .   . .||.  .. .|.......  ||| |||..  | .... . | ..      .|
ekgkvkCeeYWPade.epvlyGd....ikvtlvaeeel....edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrP

ILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
|.||||||.||||| .|.  . ...   |... .  .. |||..| . .|.| ||...|...|... ..
ivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 22-282 6e-40 132.5 In-house 3-259 (284) alignment 
Range on Protein: 22-282
Range on HMM: 3-259/284.0
EFRVLAKWTPEGM--TTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCnc
||| ..| ...|   |      | ||||. ..   || .. ..   |   |||| | ..    ...|.| .||||.||   || |  . ..  ...|   
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

ietgKIKCHQYWPLEQGQKlvfgEAPNTISVANLGAKKMapdeQCINVTTLKV-DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA------TRGNQ
    | || |||||.  .|    |    ..|  .   .       .    |      .. |.|.   .  ||| |||. .   . |.           ..
....kdkcsqywplkivik....eerfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhr

NPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERY
..|.||||||.||||. ...  . | .|  |. . . .....||  |.  .|.  || ...  ||  .|  .
anivvhcsagvgrtgvyivldvlld.rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_PTPN14_pd Subfamily PTPN14 22-278 2.4e-37 123.6 In-house 28-296 (300) alignment 
Range on Protein: 22-278
Range on HMM: 28-296/300.0
EFRVLAKWTPEG-MTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGLASDYIHANYLGT--ATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNC
|.  ..|   .. ..| .   |..|||..||   .. |. ..      ..|| |  . .  ... ...| ||||||.| . || |  ...|. ..|| . 
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

IETGKIKCHQYWPLE--QGQKLVFGEApnTISvanlgaKKMAPDEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA------TR
.| || |...|.| .  . ... ||.    ..      .|.  | ...  |.||. .   .  ||. |||. .|||.|||.   . .. |          
eedgkeksfkyfPkleskkktvefgkf..kvt......tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

-------GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
        .. |.|||||||.|||| ..    .   .  .|. . ... .. ||  |   .|.  || ....||. |.
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehnee.idikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0050432 (Phosphotyrosine protein) phosphatases II 23-280 4.4e-75 248.2 In-house 48-301 (308) alignment 
Range on Protein: 23-280
Range on HMM: 48-301/308.0
FRVLAKWT-PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVkfpGLASDYIHANYLGTA--TNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIE
|. | ... .. ... .. .| ||||| |... |. |...   .  ||||.|.|  .    .|.|||..||||.|| ..|| |  ...|....||....|
feellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve

TGKIKCHQYWPLEQG-QKLVFGeapnTISVANLGAKKmapdEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN--QNPIL
 |..||.||||||.| . |..|     ..| .|  ..    .. . |.||.. .  .. |||..|... |||| |||.     ...| . |    ..||.
ngrekcaqYwplelgggsleyg....kftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpiv

VHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
||||||.|||||..|. .. . . .. ... . |..| ||..|| ..|.. |||.|.|.|| |.. 
VHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
DSPc_SM00195 26-278 3.1e-75 248.3 In-house 9-262 (263) alignment 
Range on Protein: 26-278
Range on HMM: 9-262/263.0
LAKW-TPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGK
| .  .|. .|......|..||||..... |. |. .| .     ||||.|||. .|...||.|..||||..| ..|| | ..|||....||... | ||
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

IKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMApdeQCINVTTLKVDWGQ--GSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQN----PILVH
.||..||| |.|.| .||    .||| .   .|.    . |...||..   .   .|.....|..||||.|||...   ..||.| .  ..    ||.||
ekcdrywpeesggketfg....kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
||||.|||||.|.| .. .|. .... . . |..||||..|| ..|.. |||......| |.
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 26-278 3.1e-75 248.3 In-house 9-262 (263) alignment 
Range on Protein: 26-278
Range on HMM: 9-262/263.0
LAKW-TPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGK
| .  .|. .|......|..||||..... |. |. .| .     ||||.|||. .|...||.|..||||..| ..|| | ..|||....||... | ||
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

IKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMApdeQCINVTTLKVDWGQ--GSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQN----PILVH
.||..||| |.|.| .||    .||| .   .|.    . |...||..   .   .|.....|..||||.|||...   ..||.| .  ..    ||.||
ekcdrywpeesggketfg....kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
||||.|||||.|.| .. .|. .... . . |..||||..|| ..|.. |||......| |.
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 28-280 4.5e-44 145.5 In-house 21-272 (285) alignment 
Range on Protein: 28-280
Range on HMM: 21-272/285.0
KWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFpgLASDYIHANYLGTAT-NPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCH
 . |   |  |. || | ||| || | .. |.|.|      |||||...     .   .| .|||| .|   || |  |||.  |.|||  .| |  || 
gymppnctytayeanpdlnryadvrcieetrvvlkn..hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

QYWPLEQGQKLVFGEAPNTISvaNLGAKKMApdEQCINVTTL--KVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT---RGNQNPILVHCSAGI
 |.| . |. . ||.   |..  .   . .|     .|  |.    |       ..|.|   |||.  |.     |.|         ...|| ||||||.
lyypeklgevvkfgkyeitlt..eckeeaia..gtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagv

GRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
||| |.| | |   ..|   | . | ....|.|. |  ..|. .|.|.|. ||. ||. 
grtatfvgidyatirimenpn.iemldivremramrfqavqshmqflflyvvlmeyfig
0036941 (Phosphotyrosine protein) phosphatases II 29-281 9.9e-76 250.2 In-house 26-280 (297) alignment 
Range on Protein: 29-281
Range on HMM: 26-280/297.0
WTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVkfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQY
  .  ... .. .| .|||| |... |. |...  ..  ||||.|.|. .   ..|||..||||.|| ..|| |  ...|....||....| |..||.||
lllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPLEQGQKLVFGEapntISVANLGAKKMapDEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAG
||||.|. |..|.    ..| .|. ...  ... . ..||.|    .. |||..|... .||| |||..  . .... . |       ...|.|||||||
wpleegesltygd....ftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

IGRTGTIVAIAYVQDKMMA--GENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.||.||..|. .. . .     |... . |..|.||..||...|.. ||..|...|| ... .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
subfamily_PTPRK_pd Subfamily PTPRK 31-276 4.6e-44 145.5 In-house 32-275 (314) alignment 
Range on Protein: 31-276
Range on HMM: 32-275/314.0
PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQY
.||  .     | .|||..|.   |. |....   |   |||| |... . ..|..|| .||||..| . || .  .|.  ...|| . .|.|..|| .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

WPlEQGQKlvFGEapntISVANLGAKKMApdEQCINVTTLKV--DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT----RGNQNPILVHCSAGIG
|| |....  .|.    | |  . ..  |  |  . . ...      .. |.....|. .||| .||. . . ..|.         .. .|.|||||| |
WP.edtev..ygd....ikvelvetella..elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaG

RTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
|||| .||. | | |.  |. . . . .|.|||...  .. | || ... |.| 
rtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0040439 (Phosphotyrosine protein) phosphatases II 34-279 7.7e-67 220.8 In-house 3-247 (249) alignment 
Range on Protein: 34-279
Range on HMM: 3-247/249.0
MTTEAFSANTDKNRYQDVPCQDKGRIVVKF-PG-LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPL
...  . .| |||||.|... |  |....  ||   ||||.|.|. .   ...||..||||..| ..|| |  ........||... | |..||.|||||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAGIGR
  |. |..|.    ..| .|  ..    .. . |.||..     . |||..|.|. .||| |||..  ...... | |       ...|.|||||||.||
..ggsleygd....ftvtllsvev....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgR

TGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
|||..|. .. . .    ... . | .|.|||.||...||. || .|...|| ..|
tGtfiaaylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPN23_pd Subfamily PTPN23 34-277 1.8e-47 156.5 In-house 35-279 (288) alignment 
Range on Protein: 34-277
Range on HMM: 35-279/288.0
MTTEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGT--ATNPkKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPL
... .   ...|||..|.   |. |....  |   ||| | ..    .. | .||..|.||..|   || |  ..|.. ..|| .  |.|| |...||| 
rsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

EQGQKLVFGEapntISVANLGAKKMAP-DEQCINVTTLKVDwgqGSRTIQHLQWENWPDRGVPQTNLTAINLLSA--------TRGNQNPILVHCSAGIG
..|.  .||.    .||.    ... .  |. ....||..|     ....|||...||. |||..  | ...| .         |  . |..||||||.|
dkgetvkfgd....lsvtlksvretethvervlkletldad...avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
|||..  .  .  .. .|.  . . .... ||  | ...|.. |.  .  . | .
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0049772 (Phosphotyrosine protein) phosphatases II 35-279 1.3e-37 125.6 In-house 39-281 (314) alignment 
Range on Protein: 35-279
Range on HMM: 39-281/314.0
TTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTAtnpKKFICAQGPLENTQHSF----------WAMAI--QEKVECVIM---------
..  . .| |||||.|... |  .|. ..|.  ||||.|.|. .    .|||..|||||.| ..|          | | .  . .|  . |         
lvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LCNCIETGkikchqywpleqgqkL----------VfgeapntisvanlgakkmapdeqciNVTTLKVDWgqgSRT-IQHLQWeNWPDR
            |... . |                                                    .... . ..   .|. |..|.. ..|| 
lsrLdaAlgKtpllildgng...............neptaadlellk.........................eelydpelf...erlgikylri.pvpDg

GVPQTNL--TAINLLSATrGNQNPILVHCSAGIGRTGTIVAIAYVQDKMmagenCMAMNELIKELRSHRP-----WSIQNEFQYLYLHRVLLSYFL
..| ..    ..... .   ...|.||||.||.||||| |..||.  ..      . ..| ....|. ||      .|..  ||.. ...|| |. 
saplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 35-194 3.3e-28 93.4 In-house 26-181 (297) alignment 
Range on Protein: 35-194
Range on HMM: 26-181/297.0
TTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATN--PKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLE
..   ..   ||||.|.   |. |. ..     .||| |.|.    .  . |.|.|||||..| . || .  .. |  ..|...  | |. ||  |||  
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

QGQKLvfgEAPNTIsVANLGakKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQ
....|   .|.. . |  |   ... . . . .| |.. . . || ..| |. .||| ||| 
vqerl...kagdvv.vefls..stsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
0042113 (Phosphotyrosine protein) phosphatases II 36-278 1.3e-63 210.0 In-house 3-243 (245) alignment 
Range on Protein: 36-278
Range on HMM: 3-243/245.0
TEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA--SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLeq
. .. .| ||||| |... |  |.... .|    ||||.|.| ..   ..|||..||||..| . || |  ........||... | |..||.|||||  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG-----NQNPILVHCSAGIGRTGT
|..|..|.    ..| .|. ..    .. . |.||.|       ||...|... .||| ||| .  . ...|.. |      ...|.|||||||.|||||
gesltygd....ftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

IVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
..|. .. . . .   .. . | .|||||.||...|.. || .|...|| ..
fiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 36-276 5.1e-39 128.8 In-house 27-264 (283) alignment 
Range on Protein: 36-276
Range on HMM: 27-264/283.0
TEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLG---TATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLE
 .. . |  |||.|..  .|. |. .|   .. ||| | ..       . ||.| ||.||..|.  || |  .||. ...|| .  |  .||| |||| .
iasadenkrknrnqeivpadqwrvelk..sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

QGQKlvFGEapNTISVAnlgaKKMAPDEQCINVTTLKVD-WGQGSRTIQHLQWENWPDRGvPQTNLTAI---NLLSA--TRGNQNPILVHCSAGIGRTGT
  ..  .||   |...     | .. .   |   .|.|.   . .  . | | ..| . | .|. . ..   |.. .  |. .. ||.||||.|||||..
Gsed..yGe..ftvtlr....kettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtav

IVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
 .|..   ...   |  . . . .| .| .|.  .|.  ||  .| . | 
fiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPRA_pd Subfamily PTPRA 37-281 3.4e-47 155.9 In-house 53-298 (330) alignment 
Range on Protein: 37-281
Range on HMM: 53-298/330.0
EAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPlEQG
 .   | .|||. ..   |  |...    |   |||| | ..    . .||| ||||.|.| . || |  . |   ..|| .  |  . ||.|||| ..|
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.deG

QkLVFGEApnTISVANLG-AKKMAPDEQCINvTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN----QNPILVHCSAGIGRTGTIVA
  . .|.   ...| .   .....  . ...    .    . || .. . .. ||| ||| .    ..|| . .       .|| ||||||.||||| ..
l.vtyGni..rvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfiv

IAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.  | ... | |. . . | .|.||  ||  .| . || ....||| |.|  
ldavlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 37-278 8.7e-44 144.6 In-house 23-268 (274) alignment 
Range on Protein: 37-278
Range on HMM: 23-268/274.0
EAFSANTDKNRYQDVPCQDKGRIVVKFPGLA---SDYIHANYL-GTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLE
.  . .. ||||...   .. |....        |.|| |||. |  .. | .. .|||| || . || |  ||.|. ..|| .  |. . ||..|.| .
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

QGQKLvfGEAPNTISVANLGAKKMapDEqcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG-------NQNPILVHCSAGIGRTG
.. ..   |  . ... . ....   ..   .|..| .   . .|...|  . .|||. .|.   | ..|.  ..        .  |..|||||||||||
edyei..serygdveikvekiver..nd..ysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TIVAIAYVQdKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
  .||     . .  |. . . ... .|| .|   .|.. || ..||.|  | 
cfiaisiav.rqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPN1_pd Subfamily PTPN1 37-266 1.9e-42 140.0 In-house 27-259 (290) alignment 
Range on Protein: 37-266
Range on HMM: 27-259/290.0
EAFSANTDKNRYQDVPCQDKGRIVVKFPglASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQG-Q
  . .| ..|||.||   |. ||...      ||| |. .      ...| .|||| ||   || |  ..|  .|.|| ...| ..|||.|||| ..  .
aklpenrnlnryrdvspydhsriklera..dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

KLVFGEAPNTISVANLGAKKMapdeQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAGIGRTGTIVA
.|.. ..  .. . .   |..      ...  |.    | .|.| |  .  ||| |||..  . ...|   |       .. | ..||||||||.||.. 
ellledtklkvkliseerksy....ytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IAYVQDKMMAGEN--CMAMNELIKELRSHRPWSIQNEFQ
.  .  .. . ..  .. ... . |||..|   ||   |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadq
0037934 (Phosphotyrosine protein) phosphatases II 38-277 5.3e-61 201.6 In-house 6-241 (243) alignment 
Range on Protein: 38-277
Range on HMM: 6-241/243.0
AFSANTDKNRYQDVPCQDKGRIVVkfPGlaSDYIHANYLGTAtnpKKFICAQGPLENTQHS----FWAMAIQEKVECVIMLCNCIETGKIKCHQYWPleq
 . .| .||||.|... | .|...  .|  ||||.||.       ...|. ||||..| ..    || |  ........||....| |..||.||||   
llpenlsknrysdilpydhsrvkl..eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

GQKlVFGEapntISVANLGAKKMaPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR------------GNQNPILVHCSAGI
|.. ..|.    ..| .|. . . .|    ...   .|... .|...|... .||| |||..    ...|...|             ...|.|||||||.
gev.tygd....ftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTIVAIAYVQDKMmagenCMAMNELIKELRSHRPW-SIQNEFQYLYLHRVLLSY
|||||..|. .. ...     .. . | .|.||..||  ..|.. || .|...|| .
gRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 38-279 2.7e-52 172.4 In-house 16-265 (270) alignment 
Range on Protein: 38-279
Range on HMM: 16-265/270.0
AFSANTDKNRYQDVPCQDKGRIVVKFP--GLASDYIHANYL-GTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQG
..  ..  |||.|.  . . |....      |. || |||. |   ..||.|.|.|||..| .||| | ..|||....|. .  | |. || .||| |..
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

QKLVFgeAPNTISVANLGAKKMapdeQCINVTTLKVD-WGQGSRTIqHLQWENWPDRGVPQTNL------TAINLLSATR------GNQNPILVHCSAGI
.|. .  .  .|.|..|  .|.    .   .| |..  .|.  | . | ....|||.|||...         ...| | |       ...|.|||||||.
ekvkl..edgkikvlalseeke....egyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
|||||..|. ..   .    . . ....|.||| .|.  .|   || .|..... |  
gRtGtlialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 38-148 5.7e-08 26.7 In-house 91-195 (244) alignment 
Range on Protein: 38-148
Range on HMM: 91-195/244.0
AFSA-NTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETgkikcHQYWPleQGQK
||.  |. |||       |  |. .    ..  || | ..|      ..| .| || .|   || | .. .|. ...|    |       .|||  . . 
afnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp..dsep

LVFGEAPNTISV
| . |   |...
lewyeeditvtl
subfamily_CG7180_pd Subfamily CG7180 39-280 1.3e-34 114.2 In-house 39-292 (296) alignment 
Range on Protein: 39-280
Range on HMM: 39-292/296.0
FSANTDKNRYQDVPCQDKGRIVV-KFPGLA-SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKiKCHQYWPLEQG--
 . | .|||. .|   |. |.|. |. | . |||| | |  . . .|..|  ..| ..| ..|| .  .|....|..|..  .  | ....||| ..   
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

QKLVFGEAPNTISVANLGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPD-RGVPQTNLTAINLL---SATRGN------QNPILVHCSAGIGRT
 . .| |  .. . |||  ...    . . .|  . .     |.....|.  |.    ||    . |.|.      |..      ..|..|..| | .|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
|  .||    ...   |... . | .| || .||  ..|  .| |.  ||| ..| 
Gvylaidanlelv.ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_CG42327_pd Subfamily CG42327 39-203 2.8e-16 54.1 In-house 25-187 (319) alignment 
Range on Protein: 39-203
Range on HMM: 25-187/319.0
FSANTDKNRYQD-VPCQDKGRIVVKFPGLAS-DYIHANYL-GTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQ
  .  ||.|. . ||  .   .. . .   .  |..|.|. |    |  .|.|| .||..  .|| .  . .   .. |..  | |  .| .|.| ... 
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

K--LVFGEAPNTIsvanlgaKK-MAPDEQCINVTTLKVDWGQGSRTIQHLQWeNWPDRGVPQTNLTAINLL
.   ..|.   |.       |.  . |.  |    ||   .. || . |  . .|.. .||  . . | .|
dntslyGdilvtl.......kgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_PTPN12_pd Subfamily PTPN12 40-281 4.9e-61 201.1 In-house 38-280 (290) alignment 
Range on Protein: 40-281
Range on HMM: 38-280/290.0
SANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKL
. |. ||||.|.   || |....       |||| ||..  .......| ||||| .| . || | .. .|| |.|.|. .| ||.||..||| |....|
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeel

VFGEapntISVANLGAKKMAPDeqcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN----QNPILVHCSAGIGRTGTIVAIAYV
 |||    ..| .   |..  |   . . ||||.  . ||... .....|||.|||..  . ..|... |      ..|..||||||.||||||.|| ||
efge....fevtleeekavddd...flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

QDKMMAGEN--CMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.. . |.    .. . .|. ||| .|.  .| . || .... ..... ..
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPN6_pd Subfamily PTPN6 40-280 1.7e-49 163.5 In-house 52-299 (306) alignment 
Range on Protein: 40-280
Range on HMM: 52-299/306.0
SANTDKNRYQDVPCQDKGRIVVKFPGLAS-DYIHANYLG--TATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQK
  |. ||||. .   |. |...| |...  ||| |||.   . .. |..| .|| ||.|   || |. ||. . ..|. . .| || || .||| |. ..
penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

LvFGEapntISVANLGAKKMApDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR--------GNQNPILVHCSAGIGRTGTIV
  .|.    ||| |.  |..| | .  ...  |.. .. .|.. ......||| |||.   . ...|.  .         .. ||.||||||||||||..
e.yGk....isvtnvseksla.dYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

AIAYVQDKMMA-GENC-MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
 |  . ....  | .. . ...|.| .|..|   .| | || ......  |  .
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 40-280 1.2e-42 140.9 In-house 47-281 (315) alignment 
Range on Protein: 40-280
Range on HMM: 47-281/315.0
SANTDKNRYQDVPCQDKGRIVV--KFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEqgqKL
. | .|||| ..   || |. .        |||. ||..   . ....|.||||. .. . || .  .|..  ..|| | .|  | |. .||| .   |.
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv

VFGEapntISVAnlgaKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR----GNQNPILVHCSAGIGRTGTIVAIAYV
..|.    |.|.    .|    .. . | || |  |.  |..  |..  ||| |||.  .. .||    .     .  .|.||||||.||||| ...  |
iyGk....itvt....rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldav

QDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
 |.. | || . . ..|. .|. |   .|   || ... .||  |. 
ldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 40-281 1.4e-42 140.5 In-house 41-279 (515) alignment 
Range on Protein: 40-281
Range on HMM: 41-279/515.0
SANTDKNRYQDVPCQDKGRIVVK--FPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKL
  |  ||||...   |. |. ..       |||. | |. .  | | .|..|||.. .   || . .||.|  ..|. .  |  |||| .|||   |. .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

VFGEapntISVANLGAKKmapDEQCInVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----NPILVHCSAGIGRTGTIVAIAYV
 ||.    |.|  .  .    . . |   .|.|  |. |||.   ....|||.|||.   . . |. . . ..     |...|||||.|||| ...|  |
kfGs....ikvelvslea...ctggi.krkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsv

QDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
  ..  ..  . . .... .| .||  .| . || ... ..| ..| |
vahakttrm.vdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 40-278 1e-39 131.1 In-house 36-277 (287) alignment 
Range on Protein: 40-278
Range on HMM: 36-277/287.0
SANTDKNRYQDVPCQDKGR-IVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEqGQKLV
 |.. |||| ||   |. | .... . | |||| |||. . |. ..||.||||.  |  .|| . .....  ||..   .| .. ||..|||    . . 
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

FGeapnTISVANLGAKKMAPDeQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINL-------LSATRG--NQNPILVHCSAGIGRTGTIVA
 |      ||  |  ... |.  ..    |    .. .| .. |.. .|||.... | .  | .       . ..|   .  |..||...||||.|...|
vG....GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IAY-VQDKMMAGEncMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
.   |.     |.  . .   .  || .|   .|   |. .|   | .|.
tlvlvsrledlGr..vdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 41-278 5.3e-48 158.4 In-house 8-242 (250) alignment 
Range on Protein: 41-278
Range on HMM: 8-242/250.0
ANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIkCHQYWPLEQGQKlv
.| .|||| |.   |. |.|..       |||| | .| . .. | || .||||..|   || | ..||.. ..|| |  |..|  .||||| |. .|  
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek..

FGEapntISVANLGAKKMApDEQcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN-Q----NPILVHCSAGIGRTGTIVAIAYV
.|.    . |  |  ...| | . . .  |     ...|....|.. .|||.|||..  ....||.  . . |    .|..|.||||.||.|. .||  |
yGd....vtvsllskeefa.dyt.krklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

QDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 ...   |. . . ..|| || .|| ... . || ......| . 
lerlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 41-275 3.3e-43 142.6 In-house 2-236 (237) alignment 
Range on Protein: 41-275
Range on HMM: 2-236/237.0
ANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLG-TATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPlEQGQKLVF
 |  |||| .. . |. |.|.| .| .|||| |.||      |||.|.||||||.. . || |  |||   ..||   ||  ..|||.||| .  |   .
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaay

GEApnTISVAnlgAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAI----NLLSATRG--NQNPILVHCSAGIGRTGTIVAIAYV
|    |.|.     |.   |     ... |    .. | |.  |.  ||||||||   . .    |..  ..   .  | ..|||||.|||| .. |  .
gvl..tvslk...kkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

QDKmMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
  .    .. . . . .. .   ||. || . ||...|...|
lrq.akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 41-275 6.8e-31 102.3 In-house 7-238 (239) alignment 
Range on Protein: 41-275
Range on HMM: 7-238/239.0
ANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGT-ATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGqKl
 |  |||| ..   |. |.|..       |||| |.||     .|| .|..|| .| .   || |  ||.   ..||   ||  | |||||||     | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k.

vFGEAPNTISVANLGAkkmapdeQCINVTTLKVDWGQG-SRTIQHLQWENWPDRGVPQTNLTAINLLSA----TRGNQNPILVHCSAGIGRTGTIVAIAY
 . .   |.  ... |       . |  | .  . ||   | . . ..  |||.||||   . . |       .     | ..|||||.||||... |  
.ycnlrvtlrktevfa.......dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

VQDKMMaGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
.  .    .. . . . .| .|  ||  .|   ||...|  .|
mlrqak.kqktvdifnyvkairedrphmvqtseqyvfihlavl
Y_phosphatase Protein-tyrosine phosphatase 42-275 5.1e-70 230.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 42-275
Range on HMM: 1-234/235.0
NTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGE
| .||||.|... || |. .|  . .||||.|||. . ...||||..||||..| ..||.| .||||....||... | |. ||.|||| |....| .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

APNTISvanlgaKKMAPDEQCINVTTLKVDWGQGS---RTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----NPILVHCSAGIGRTGTIVAIAYVQ
   ..       .|   ||. .....|...  ...   |....|...||||.|||...   ..|. . . ..    .|..||||||.|||||.||. .. 
ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
... | |... . ...||||..|| ..|.. || .|....|
eqlea.eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 42-275 5.1e-70 230.9 In-house 1-234 (235) alignment 
Range on Protein: 42-275
Range on HMM: 1-234/235.0
NTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGE
| .||||.|... || |. .|  . .||||.|||. . ...||||..||||..| ..||.| .||||....||... | |. ||.|||| |....| .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

APNTISvanlgaKKMAPDEQCINVTTLKVDWGQGS---RTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----NPILVHCSAGIGRTGTIVAIAYVQ
   ..       .|   ||. .....|...  ...   |....|...||||.|||...   ..|. . . ..    .|..||||||.|||||.||. .. 
ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
... | |... . ...||||..|| ..|.. || .|....|
eqlea.eeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 42-271 1.9e-49 163.0 In-house 50-273 (301) alignment 
Range on Protein: 42-271
Range on HMM: 50-273/301.0
NTDKNRYQDVPCQDKGRIVVKFPGLASdYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGE
. ||.||. |||. .  . |   |     ||||.. |  .|..||..||||.||.. |||| .| .|| ..||.. .|  . ||..| |.. ..||  | 
pkdkhryptvPckPstavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

APNTISVANLGAKKMApDEQCINVTTLKVDWgqGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgE
   .|   .|  .|    .. ..|.    ..   .||. | |...|.|||||..     .|.   .  ..||.|||||||||. . ..  |.  .. | .
fkikiknkelilnkki.skrtlevedstgkf..atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea.d

NCMAMNELIKELRSHRPWSIQNEFQyLYLH
. . ..| .|.|| ||  ..|...| ||  
ptieltealkhlrehrwngvqtnsq.lywm
0041856 (Phosphotyrosine protein) phosphatases II 42-281 5.7e-46 151.7 In-house 1-174 (182) alignment 
Range on Protein: 42-281
Range on HMM: 1-174/182.0
NTDKNRYQDVPCQDKGRivvkfpglASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCncietgkikCHQYWPleqgqklvfge
| |||||.|... | .|         .|||.||..  .  ...||..|||| .|  .|. |  .... ....|.         ...|||           
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

apntisvanlgakkmapdeqcinvttlkvdwGQGSRTIQHLQWENWPDRGVPQtNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKmmage
                                   |.. .... .||| |||    ...... . . ...|.|||||||.|||||.||. ..  .     
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....

nCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
  . . | .|..||.|| ..... || .|...|| ..| .
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 42-275 6.2e-31 102.4 In-house 7-237 (239) alignment 
Range on Protein: 42-275
Range on HMM: 7-237/239.0
NTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGT-ATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGqKlv
|  |||| ..   |. |.|..       |||| |.||     .|| .|..|| .| .   || |  ||.   ..||   ||  | |||||||     |  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k..

FGEAPNTISVANLGAkkmapdeQCINVTTLKVDWGQG-SRTIQHLQWENWPDRGVPQTNLTAINLLSA----TRGNQNPILVHCSAGIGRTGTIVAIAYV
. .   |.  ... |       . |  | .  . ||   | . . ..  |||.||||   . . |       .     | ..|||||.||||... |  .
ycnlrvtlrktevfa.......dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

QDKMMaGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
  .    .. . . . .| .|  ||  .|   ||...|  .|
lrqak.kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 44-278 1.4e-25 84.8 In-house 49-344 (350) alignment 
Range on Protein: 44-278
Range on HMM: 49-344/350.0
DKNRYQDVPCQDKGRIVVK----------FPGLASDYIHANYLGTA-----TNPK-KFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQ
 ||||...   .. |. .|              ..||| ||||  .      ||. |.| .|.|| .| . |. . .. ||. ...| . .| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPLEQGQK--L-VFGEAP-----NTISVANLGAKKMAPDEQCIN--------VTTLKVDWGQG-SRTIQHLQWENWPDR---GVPQTNLTAIN------
||.  . ..  . .          | .|    . || |.|.. |.         .  ..         . .||..||.|      |.  |.|..      
YWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndli

--LLS---ATRGNQNPILVHCSAGIGRTGTIVAIAYVQD-----KMMAGE-----NC----MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
  | .       ...|||||||||.|||||.|.. ..       ...  |             .. ...|||. |   .||  |.....  || ||
ddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 50-298 3.5e-33 110.0 In-house 26-283 (290) alignment 
Range on Protein: 50-298
Range on HMM: 26-283/290.0
DVPCQDKGRIVVKFPG--LASDYIHANYLgTATNPKKFICAQGPLENT-------QHSFWAMAIQEKVECVIMLCNCIET----GKIKCHQYWPLEQGQK
.||   . |.| |  |  ...||||||.. |  |  ..|  | |.|..         .|| || ||||. |.|||.  |     ..  | .| | . |..
evpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

LVFGEApnTISVanlgaKKMAPDEQcINVTTLKVDWGQGS-RTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQD
| |.    |..      |..  ... ... .| | ....   |..| . ..| .. |.....|...|..  . .. |..|||  || |  .. ||     
lkfkgl..tvkC.....kskekedd.vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQ

KMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAELLV----GDYGEKY
|..  .. . .....|.||..|   |... .. .   ... .. | ..... |        .. | |
kiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeekety
0046846 (Phosphotyrosine protein) phosphatases II 59-277 3.8e-44 145.8 In-house 3-172 (176) alignment 
Range on Protein: 59-277
Range on HMM: 3-172/176.0
IVVKFPGLASDYIHANYLGTAtnpkKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLvfgeapntisvanlgakkmap
... ...| .|||.||.. ..    ..|. ||||..|  .|..|  ......|..|....|.|..||..|||.... ..                     
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

deqcinvttlkvdwgqgsrtiqHLQWENWPDRGVPQTN--LTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAyvqdkMMAGENCMAMNELIKELRSH
                      . .. .||| |||. .  |......   . . .|.|||||||||||||.||.      ..  |... ..| ....|..
......................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreq

RP-WSIQNEFQYLYLHRVLLSY
|| ...|.. || .|....| .
RplgavqtpeQyrflyefelll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 64-129 6.3e-12 39.5 In-house 86-153 (349) alignment 
Range on Protein: 64-129
Range on HMM: 86-153/349.0
PGLASDYIHANYLGTA--TNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYW
 |   ||| ||||  .  .  ||.|. | ||  | . |. . . ..|. |. | .  |..  ||..||
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
0044763 (Phosphotyrosine protein) phosphatases II 67-278 2e-32 107.7 In-house 17-171 (178) alignment 
Range on Protein: 67-278
Range on HMM: 17-171/178.0
ASDYIHANYLGtatnPKKFICAQGPlentqHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGqklvfgeapntisvanlgakkmapdeqcinvt
.||||.|..      |  ......|      .....  .... ....|.. .| |..||..||| | |                                
rsdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................................

tlkvdwgqgsrtIQHLQWeNWPDRGVPQ---TNLTAINLLSATR-GNQNPILVHCSAGIGRTGTIVAIAYVQDKmmagenCMAMNELIKELRSHRPwSIQ
            ||.|.. ..|| |||.     | ..... . .  ...|.|||||||.||.||.||. ..          . ..| |...|..||  ..
............iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivp

NEFQYLYLHRVLLSYF
|. |. .|... | ..
npgqlrqLyefelrll
subfamily_eak_pd Subfamily eak 67-194 1.9e-06 21.5 In-house 77-196 (332) alignment 
Range on Protein: 67-194
Range on HMM: 77-196/332.0
ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApntisvaNLGAKKMaPDEQCINVT
   || |  .  .   .|.| .  . |.    || | ...|  ....| . .| .  |  .|.| .  ..| ||         ..  |.    .. ... 
rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil.......dverkef.vkrniletr

TLKVDWGQGSRTIQHLQWENWPDRGVPQ
 |..  |  .  ..| .   | .  .|.
llelskGnethrvlhykvfGwtettlpk
0051429 (Phosphotyrosine protein) phosphatases II 68-281 1.3e-46 154.7 In-house 4-228 (272) alignment 
Range on Protein: 68-281
Range on HMM: 4-228/272.0
SDYIHANYLGTATN---PKKFICAQGPLENTQHSFWAMaIQEKVECVIMLCNCIETGKIKCHQYWpleqgqklvfgE-----------------APNTIS
|.||.|...|. ..   |.......|||..|...||..  .... ....|... | |. ||..||           .                   . ..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw...........pgirylhlpilddsaptilygalr

VANLGAKkMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNltAINLLSATRGnQNPILVHCSAGIGRTGTIVAIAYVQdKMMAGENCMA--
| .|  . . .|  . . .  ..   . .|.. ||.. .|||.||||     ..||.. .  ..|.|||||||..||||.||. ..    .  |  ..  
vtllsee.llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddY

------MNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
      . | ..|||..||...|.| |||.|...|| .. . 
lltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 68-272 2.2e-41 136.8 In-house 2-164 (174) alignment 
Range on Protein: 68-272
Range on HMM: 2-164/174.0
SDYIHANYLGTATNPKKFICAQGPLEntqhsFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLeqgqklvfgeapntisvanlgakkmapdeqcinvtt
||||.|..|.    ....|. ||||.     ||.|  ......|.||....| |. ||..|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

lkvDWGQGSRTIQHLQWENWPDRGVPQTNLtAINLLSATRGN-----QNPILVHCSAGIGRTGTIVAIAYVQDKMMagENCMAMNELIKELRSHRPWSIQ
   ..   .|.. .... .|||.||| ..   ...... .       ..|.|||||||.|||||.||. ..   ..  |. .   .|..|||..||...|
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvq

NEFQYLYLHR
.. || .|. 
tpsQyrflyy
0043147 (Phosphotyrosine protein) phosphatases II 68-271 1e-39 131.4 In-house 5-154 (172) alignment 
Range on Protein: 68-271
Range on HMM: 5-154/172.0
SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCietgkikchqywpleqgqklvfgeapntisvanlgakkmapdeqcinvtt
||||.|.|| .   |..||. |||| || ..||.|  .... ....|...                                                  
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

lKVDWGQGSRTIQHLQWENWPDRGVPqTNLTAINLLSATRG-----NQNPILVHCSAGIGRTGTIVAIAYVQdkmmageNCMAMNELIKELRSHRPWSIQ
  .|. . .|.. .... .||| ||| .    ...|.  .      ...|.|||||||.|||||.||. ...        .. . | ....|..||...|
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavq

NEFQYLYLH
|. || .|.
npsqyrfly
0051082 (Phosphotyrosine protein) phosphatases II 68-274 2e-32 107.2 In-house 3-149 (151) alignment 
Range on Protein: 68-274
Range on HMM: 3-149/151.0
SDYIHANYLGTAtnpkkFICAQGPLEntqhSFWAMAIQEKVECVIMLCNCIETGkiKCHQYWPLEQgqklvfgeapntisvanlgakkmapdeqcinvtt
||||...|..       ... .|||.     |...  .... ....|..  |.|  .|..|.| ..                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

lkvdwgqgsRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN-QNPILVHCSAGIGRTGTIVAIAYVQdKMmagencMAMNELIKELRSHRPWSIQNEFQ
         ... |.....||| |.|..  .....|.. . . ..|.|||||||.|||||.||.  .   .      . ..| ..|.|..|| ..| . |
.........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg......vsleealeeyrlkrpgvvqpnqq

YLYLHRVL
.|.....|
flfqlfal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 68-149 1.7e-06 22.4 In-house 13-87 (130) alignment 
Range on Protein: 68-149
Range on HMM: 13-87/130.0
SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETgkikcHQYWPleQGQKLVFGEAPNTISVA
 .||.|...|   . .... .| || .|   || | ..  |. ...|    |       .|||  . . | . |   .....
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp..dsePlewyeediivtlt
0049260 (Phosphotyrosine protein) phosphatases II 80-271 1.6e-37 123.9 In-house 6-143 (152) alignment 
Range on Protein: 80-271
Range on HMM: 6-143/152.0
TNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWpleqgqklvfgeapntisvanlgakkmapdeqcinvttlkvdwgqgsrti
 .|..||..|||..||  .|| |  . .. ...||... | ||.||.||.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

qHLQWENWPDRGVPQTNLTAINLLSAT----RGNQNPILVHCSAGIGRTGTIVAIAYVQdkmmageNCMAMNELIKELRSHRPWSIQNEFQYLYLH
 . .. .||| |||.     . || .     . ...|.|||||||.|||||.||. ..        . . . | .. .|..|| ...|. |. .|.
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 83-264 6.8e-10 33.4 In-house 4-189 (198) alignment 
Range on Protein: 83-264
Range on HMM: 4-189/198.0
KKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVanLGAKkmaPDEQC-INVTTLKVDWGQGSRTIQH
...|..| || .|   || |  .     ..|. .     .     |||  .     .|    |  .  . .|   ||      . | ..     .| | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittk...pdytitaliltnnttappstreish

LQWENWPDRGVPQTNLTaINLLSATR--------GNQNPILVHCSAGIGRTGTIVAIAY-VQDKMMAGENCMAMNELIKELRSHRPWSIQNE
 |.  | ..  |.  |  . .. |.|         .. |..|||| | | || .||.   |. .  .    . . |. | ||  |   |   
yqftswkekttpnvalf.vgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 83-264 7.8e-10 33.2 In-house 5-190 (199) alignment 
Range on Protein: 83-264
Range on HMM: 5-190/199.0
KKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVanLGAKkmaPDEQC-INVTTLKVDWGQGSRTIQH
...|..| || .|   || |  .     ..|. .     .     |||  .     .|    |  .  . .|   ||      . | ..     .| | |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittk...pdytitaliltnnttappstreish

LQWENWPDRGVPQTNLTaINLLSATR--------GNQNPILVHCSAGIGRTGTIVAIAY-VQDKMMAGENCMAMNELIKELRSHRPWSIQNE
 |.  | ..  |.  |  . .. |.|         .. |..|||| | | || .||.   |. .  .    . . |. | ||  |   |   
yqftswkekttpnvalf.vgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 88-277 1.2e-28 94.5 In-house 96-287 (302) alignment 
Range on Protein: 88-277
Range on HMM: 96-287/302.0
AQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEA-PNTISVANLGaKKmAPDEQCI-----NVTTLKVDWgQGSRTIQH
   |  .|.  .||.  | .|  |. ||. .| .. || .|.  . |..| ||.   .|.|| .   ..   | . .     ...  |.   .  .|.. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdl.ee.ftdkksfklytveiknekkkk.kvkktvdi

LQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
|..  ||| | |.   ||...|      .. .|||||||.|||||.||| |  . . . ..   . .... .|. |  ..|.| | .||  ..   
lafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_hpo-7_pd Subfamily hpo-7 94-284 7.9e-24 79.0 In-house 45-233 (263) alignment 
Range on Protein: 94-284
Range on HMM: 45-233/263.0
NTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANLGAKKMAPDEQCINVTTLKvdwgQGSRTIQHLQWENWPDRGVP
.| ..|. .  | | | |.|||.  | |. || .|.|||. .|... .   ......   . .   .. ...   |    .  .|..| ..  |...  |
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanv..nvcttkvqsdvllktlellstlgeK....kkthtvkhysykgWiekndp

QTNLTAINLLSATRGNqNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENC-----MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKE
.     .|.| ..|.   .. ||||.||||.   . .  |  ||.   .      .   .|..||||.|. .|.. .|  .   ..| ..|. . .
elareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfak
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 95-278 5.8e-26 86.1 In-house 40-221 (255) alignment 
Range on Protein: 95-278
Range on HMM: 40-221/255.0
TQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANlgakkmAPDEQCINVTTLKVDWG--QGSRTIQHLQWENWPDRGV
|   |. . .| | | |.|||.  | |. ||..|.|||. .||.. .   ......      .  .  .   ..    |  .  .|..| ... |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladv..nvtttk......ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PQTNLTAINLLSATRGNqNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENC-----MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
|.      |.| . |    ...||||.||||. . | . .|  ||.   .      .   .|..||||.|. .|.. .|  .   ..| ..
Pelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 127-276 1.2e-23 78.9 In-house 1-141 (145) alignment 
Range on Protein: 127-276
Range on HMM: 1-141/145.0
QYWPLEQGQKLVFGEAPNTISVANLGAKKmapdeqCINVTTLKVDWGQGSRTIQHLQWENWPDRGVP---QTNLTAINLLSATRGNQNPILVHCSAGIGR
.||| |  ..| .|  |.......|   .         | .|  .    .|.. .... .|||.|||   .. |...... . . . .|.|||||||.||
pywpseilpglylgslptaldlellkdlg......ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgR

TGTIVAIAYVQDkmmagENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
|||.||.  .       .. . . | ....||.||....|. |. .|....| 
tgtlvaaylmll.....lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 153-278 2.2e-15 50.9 In-house 68-194 (440) alignment 
Range on Protein: 153-278
Range on HMM: 68-194/440.0
AKKMAPDEQCINVTTLKvdwGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA-----TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMN
  |  ||.. || . ..   |  |||... ... |||.|||.     ....        .  . |.||||||| |||| |.|.  .  .    .  . . 
evkgvpdsdyinasyin...giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsd.qidif

ELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 .|. .|. ||  .|   || ..| ..|  .
sfinsmrnnrpqmvqtpeqyafvheavlegl
0048179 (Phosphotyrosine protein) phosphatases II 162-272 3.3e-22 74.2 In-house 33-139 (144) alignment 
Range on Protein: 162-272
Range on HMM: 33-139/144.0
CINVTTlKVDWGQGSRTIQHLQWENWPDRGVP---QTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQdkmmagENCMAMNELIKELRSHRP
 ||.|. . ..    |.. .... .|||.|||   .  |...... . . . .|.|||||||.|||||.||.  .       .. . ..| ....||.||
vinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrp

WSIQNEFQYLYLHR
....|. |. .|..
gavpnpgqlrfLle
PTPc_motif_SM00404 174-268 1.4e-08 29.7 In-house 44-131 (140) alignment 
Range on Protein: 174-268
Range on HMM: 44-131/140.0
QGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAGENCmAMNELIKELRSHRpWSIQNEFQYL
. ...| ... ..     . .    ... ... . ..  .|||| ||. |..|.. |||    .|  ...  ..| .. ... |  .|.  ....
nsgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli.iaY....lmryrql.slaeayefvkerR.piispnlnfv
PTPc_DSPc_SM00012 178-275 3.5e-29 96.4 In-house 1-104 (105) alignment 
Range on Protein: 178-275
Range on HMM: 1-104/105.0
TIQHLQWENWPDRGVPQTNLTAINLLSATRGNQN------PILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLH
|..|... .||| |||..    ..|| |.. |.|      |..||||||.|||||.||.... .......... . ...||||..||...|.| |||.|.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RVLL
|.||
rall
0038934 (Phosphotyrosine protein) phosphatases II 179-272 3.9e-12 41.7 In-house 80-171 (194) alignment 
Range on Protein: 179-272
Range on HMM: 80-171/194.0
IQHLQWENWPDRGVPQTNLT-----AINLLSaTRGNQNPILVHCSAGIGRTGTIVAIAYVQDkmmageNCMAMNELIKELRSHRPWSIQNEFQYLYLHR
|..|..    |  ||.....     ...     . ... ..||| ||.|||||.|| . ..       ..| ..| |. .|. || .|.|  .. .|..
ieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr......lgmsaeeAialfrekRpgaipnqdyleallk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 179-235 1.1e-08 28.8 In-house 220-290 (349) alignment 
Range on Protein: 179-235
Range on HMM: 220-290/349.0
IQHLQWENWPDRGV---PQTNLTAINLLS-----------ATRGNQNPILVHCSAGIGRTGTIVAIAYVQD
.  ||  ||.| ..   |.. |.|..  .               . ...||||||| ||||..| . .. .
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_DSP10_pd Subfamily DSP10 182-258 8.2e-08 26.3 In-house 64-134 (159) alignment 
Range on Protein: 182-258
Range on HMM: 64-134/159.0
LQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYVQDKMMagencMAMNELIKELRSHRP
.. ..   . . |    |.. .   | ... .|||| ||| |  |.| |||.  ..      ...|.  |  .. ||
ipvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv.iaYlmkhln.....lslndaykfvkekrp
subfamily_PTPDC1_pd Subfamily PTPDC1 187-270 4.4e-09 31.0 In-house 90-168 (182) alignment 
Range on Protein: 187-270
Range on HMM: 90-168/182.0
WPDRGVP--QTNLTAINLLSATRGNQnPILVHCSAGIGRTGTIVAIAYVQDKMMAGEncmamnELIKELRSHRPWSIQNEFQYLYL
|.| ||.  .. |. . ... .  ..  . ||| || |||| ..|   |  | ...|      . || .||.|| |||   |   .
wkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelv
subfamily_DSP19_pd Subfamily DSP19 187-258 8.3e-08 26.7 In-house 66-131 (152) alignment 
Range on Protein: 187-258
Range on HMM: 66-131/152.0
WPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAgENCMAMNELIKELRSHRP
 |.  . .   .|.. .  .| ... .||||.||. |. ..| |||    .|. .. . ..| ....|..||
lpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iay....lmk.keelsleealelvrearp
subfamily_CDC14_pd Subfamily CDC14 192-270 1e-07 26.2 In-house 246-318 (328) alignment 
Range on Protein: 192-270
Range on HMM: 246-318/328.0
VPQTNLTAiNLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQdkmmagENCMAMNELIKELRSHRPWSIQNEF-QYLYL
.|. ..   ..|...   .  | ||| ||.|||||..|   ..      .  .. .| |  ||  || |.     ..|. 
tPsdaivk.kfleiaekaeGaiavhCkaGLGrtGtLiacylmk......hyrftaaeaiawlricrPGsvigpqqkflee
subfamily_DSP15_pd Subfamily DSP15 194-233 5.9e-06 20.4 In-house 62-100 (151) alignment 
Range on Protein: 194-233
Range on HMM: 62-100/151.0
QTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIaYV
.    ..... ..| ... .|||| ||. |  |.|.. |.
kffkesvefihkcRlkeenvlvhClaGvsRsvtlvva.Yl
DSPc Dual specificity phosphatase, catalytic domain 197-265 1.3e-09 33.0 Pfam-A 60-123 (133) alignment 
Range on Protein: 197-265
Range on HMM: 60-123/133.0
LTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAGENCmAMNELIKELRSHRPWSIQN-EF
  |.. ... . ... .|||| ||| |..|.. |||    .|  .|.  .|| .. ... |..  .| .|
eeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknl.slneAyefvkerrskispnagf
DSPc Dual specificity phosphatase, catalytic domain 197-265 1.3e-09 33.0 In-house 60-123 (133) alignment 
Range on Protein: 197-265
Range on HMM: 60-123/133.0
LTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAGENCmAMNELIKELRSHRPWSIQN-EF
  |.. ... . ... .|||| ||| |..|.. |||    .|  .|.  .|| .. ... |..  .| .|
eeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknl.slneAyefvkerrskispnagf
subfamily_PTPMT1_pd Subfamily PTPMT1 197-264 1.8e-06 22.5 In-house 94-155 (171) alignment 
Range on Protein: 197-264
Range on HMM: 94-155/171.0
LTAINLLSATRGNQNPILVHCSAGIGRTGTIVAiAYVqdkmMAGeNCMAMNELIKELRSHRPWSIQNE
. ...... .. ... . ||| || ||..|.|| .|.    |   . . ..| .| |.. |.    ..
ekgvefiekvaskgkrvYvHCkaGrgRsatlva.cyl....mkk.eklspeeAlkalkkkRkiirlak
subfamily_DSP6_pd Subfamily DSP6 198-239 3.5e-07 23.9 In-house 81-121 (158) alignment 
Range on Protein: 198-239
Range on HMM: 81-121/158.0
TAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYVQDKMMA
 ||...  .| ... .|||| ||| |. |.. .||.  |.. 
eaiefidearskkskvlvhClaGisrsvtvt.laylmkklal
subfamily_DSP8_pd Subfamily DSP8 199-268 5e-06 20.2 In-house 82-144 (159) alignment 
Range on Protein: 199-268
Range on HMM: 82-144/159.0
AINLLSATRGNQNPILVHCSAGIGRTGTIvAIAYVQDKMMagencMAMNELIKELRSHRpWSIQNEFQYL
... .  .. ..  .|||. ||| |  |. ||||.  ..      |...|  . ....|  .|......|
svefidkaksengrvlvhvlaGisrsatv.aiayimktle.....msldeayrfvkekr.ptispnlnfl
subfamily_CG42327_pd Subfamily CG42327 200-277 2.1e-12 41.3 In-house 237-314 (319) alignment 
Range on Protein: 200-277
Range on HMM: 237-314/319.0
INLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
|.  |.|| .| |. |||| |.||||...|      ..   .. . . .|.  .|  |  ....  || ....||  |
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-276 1.4e-10 35.5 In-house 219-293 (297) alignment 
Range on Protein: 201-276
Range on HMM: 219-293/297.0
NLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
. | |    . ..|||||||.||.| .|    . .|.  .     .. ... ||. |.  .|   |. .|. . | 
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlk
PTEN_1 202-288 1.1e-12 43.2 In-house 119-190 (196) alignment 
Range on Protein: 202-288
Range on HMM: 119-190/196.0
LLSATRG---NQNPILVHCSAGIGRTGTIVAiAYvqdkMMAGENcMAMNELIKELRSHR-PWSIQnefqylylhrvllSYFLERYKETYAE
 .   .    |.| .|||| ||.||.||.|| ||    .|. .. . ..| .. .|..| |....             | ..||..| .||
sfiewllsdpngnvVlVHCkaGlgRsGtvva.ay....Lmykgk.ltadeAlelvrekRppgapn.............spsqerlleyfae
subfamily_DSP23_pd Subfamily DSP23 208-263 2.6e-08 28.6 In-house 82-131 (148) alignment 
Range on Protein: 208-263
Range on HMM: 82-131/148.0
GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgencmaMNELIKELRSHRPWSIQN
 ... . |||  | |||||..|  .|. . .|        | | |.|  || |.. 
ekneavsvhcllgrgrtgtmlacylvkerkla......aaeaiaevrrlrpgsvet
subfamily_PRL_pd Subfamily PRL 209-269 4.1e-06 20.9 In-house 89-141 (151) alignment 
Range on Protein: 209-269
Range on HMM: 89-141/151.0
NQNPILVHCSAGIGRTGTIVAIAYVqdkmmagENCMAMNELIKELRSHRPWSIqNEFQYLY
... . ||| ||.||.  .||.| .       |. | ... .. .|..|  .| |. |  .
pkstvavhcvaGlGraPvlvalali.......eaGmkyedavefirekrrgai.nskqlkf
subfamily_PTEN_pd Subfamily PTEN 209-259 5.4e-06 21.5 In-house 113-161 (184) alignment 
Range on Protein: 209-259
Range on HMM: 113-161/184.0
NQNPILVHCSAGIGRTGTIVAiAYVQDKMMAGENCMAMnELIKELRSHRPW
..| . ||| || ||||.... ||.  ...  ..  |. || .| |..   
kknvvvvHCkaGkGRtGvliv.ayllkslllekaeeal.elfaeaRtknkk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 214-275 1.5e-09 32.1 In-house 2-62 (69) alignment 
Range on Protein: 214-275
Range on HMM: 2-62/69.0
LVHCSAGIGRTGTIVAIAyVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
.||||.| |||||..||  |.   .  |  . . . .. .|  ||  . || .|...|  | 
vvhcssgtgrtgtfiaim.vemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 215-274 4.4e-09 30.5 In-house 2-60 (69) alignment 
Range on Protein: 215-274
Range on HMM: 2-60/69.0
VHCSAGIGRTGTIVAIAyVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVL
||||.| ||||| .||  |.   .  |  . . . .. .|  ||  . || .|...|  |
vhcssGtGrtGtfiaim.vemarikseklvdifnnvqymrkcrpmmvmneneymfihdal