Gene F47B3.7 in Caenorhabditis elegans

Synonym: CELE_F47B3.7, F47B3.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP092_AA protein Get Run
CeleP092_AA_50-332 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 42-329 4.1e-81 268.0 In-house 8-292 (297) alignment 
Range on Protein: 42-329
Range on HMM: 8-292/297.0
TAQSRRMHVSIVRPWVHHTLNKGVSKLRDEFSEVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGAS---SDYIHANYVGISIK-PKKFICTQ
. .|  ...|..  .....  .. ..|. || |. . .|.  . ... | .||||.|| . . .||.|.. . .   ||||.|.||    . ..|||.||
llesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

GPKDSTIYDFWAMVIQDNVESIIMLCKVIELARvKCEQYWPAVEGqtntyvsKGHTITINNLGVGTlspdDDFINVTNLELVWAGKTRSITHYQWTNWPD
|| ..|..||| || . .|..|.||.| .|| | ||.||||  .|       . ...|...|.| .    .| ..|..||..  |..| .||.|.|.|||
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkveh....ldgytvrtlevtnngesrtvthfqytgwpd

HGAPPINMGAINLIEAVNY------DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLEL
||.||.    ....|.|.       . .||.|||||||||.||.... |... .  .  . |... |.|.|.||..|.||. ||......|||...  
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 47-327 9.2e-80 263.9 In-house 8-305 (307) alignment 
Range on Protein: 47-327
Range on HMM: 8-305/307.0
RMHVSIVRPWVHHTLNKGVSKLRDEFSEVANKNP----NVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGAS---SDYIHANYV--------GISIKPK
 . . .   .|. .| .....|. || .. . ..    .  . ... | .||||.|| . . |||.|.. . |   ||||.|.||        .. ....
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

KFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVeGQTNTYVSkghtITINNLGVGTlspdDDFINVTNLELV---WAGKTRSIT
|||.||||...|..||| |. . .|. |.||.. .||.|.|| ||||   |.. ||      .|...|.. .    .| . |..||.      |..| .|
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh....ldgytvrtlevtdldgtgesrtvt

HYQWTNWPDHGAPPINMGAINLIEAVNY------DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINC--KDMKKLVEEIRNQRHYAIQTEAQYMYIHR
|...|.|||||.||    ....||.|.       . .||.|||||||||.||.... |... . ..  .   |. . |...|.||. |.|.. ||.....
hfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

VLLEYFL
.|||..|
allelll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 47-336 7.7e-54 177.3 In-house 8-299 (310) alignment 
Range on Protein: 47-336
Range on HMM: 8-299/310.0
RMHVSIVRPWVHHTLNKGVSKLRDEFSEV-ANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGA-SSDYIHANYVGISIKPKKFICTQGPKDSTI
. ..  .  ..  | . |.  |  ..  . |.... .  .|.| .  ||||.|. | ...|| |. | .   ||||||||      . |||.||| . ||
lkylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhti

YDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVeGQTNTYVS--------KGHTITINNLGVgTLSPDDDFINVTNLELvwagKTRSITHYQWTNWP
 ||| |..|.  |||..|||| |  | ||  |||.. | |.||            . . | || | |. ||.  ..    .|    |   ..  .| |||
idfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygcirvtnlsesseefeicnlav.tfvpdnvpvdeqpanl....kelrvslikwpnwp

DHGAPPINMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLElHKETYEG
| | |  .  ..      .    |.|||||||..| ...| . | .||. .| .  |..... |....|   |||| ||..|.|| . .    ..|. | 
drgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkv.daeevktellksraiciqtelqyliidrvriifarg.etevaek
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 47-138 1.2e-06 22.5 In-house 4-95 (95) alignment 
Range on Protein: 47-138
Range on HMM: 4-95/95.0
RMHVSIVRPWVHHTLNKGVSKLRDEFSEVANKN-PNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDgASSDYIHANYVGISIKPKKFICTQG
 .|||..   |     .   .. .||  ..     .  | . ..|  |||. .|   . |||.|||    |||| | .|    . . .|..||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk.rdsdyinacfvdgyarkncyiaaqg
subfamily_PTPRD_pd Subfamily PTPRD 49-330 1.9e-69 229.8 In-house 6-285 (564) alignment 
Range on Protein: 49-330
Range on HMM: 6-285/564.0
HVSIVRPWVHHTLNKGVSKLRDEFSEVANKnPNVPV--DAFKSNPEKNRYTDIKCIEKTRVILT--TDGASSDYIHANYVGISIKPKKFICTQGPKDSTI
.|. .. .|..   ..  |.  |. .. .. .....   . . | .|||| .|   ...||.|.      .|||| |...    |.|..| ||||. .||
pvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

YDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVeGqTNTYvsKGHTITINNlgvgTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPIN
 ||| || . |...|.|| |. |  .|||..|||.  | | ||   . |.|...    .    |  |   .|.     ..| ......|.|||||.|   
edFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety..geltVtlee....eeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesa

MGAINLIEAVN----YDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELH
 . ..||. |.     |. |.||||||||||.|| . |. ..... .  .  |. . |...|.|| . .||| ||..||...||.    .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 51-356 4.8e-193 634.9 In-house 1-307 (307) alignment 
Range on Protein: 51-356
Range on HMM: 1-307/307.0
SIVRPWVHHTLNKGVSKLRDEFSEVANKNPN-VPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWA
|.|.|||..||.|||..|.|||...|.|.|. |.|.||..|..||||.|.||..|.|.....||..||||||||.||.||||||||.|||...|.|.|||
svvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwa

MVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHTITINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAIN
|.||..|||.||||||||||..|||||||..|||.........||...|||...|.||.|.||||.|...||.|.|.|.|.||.||||.|.|.||..|||
maiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltain

LIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTKNYEEKYAK
|.|||.|||||||||||||||||||||.|||..||||.|||||||||||||.|.||||||||||||.|.|||||||||||.|||||.|||||||||||||
lleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekyak

WLDDYNT
|||||||
wlddynt
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 51-342 1.3e-88 291.6 In-house 9-305 (305) alignment 
Range on Protein: 51-342
Range on HMM: 9-305/305.0
SIVRPWVHHTLNKGVSKLRDEFSEVAN-KNPNVPVDAFKSNP------EKNRYTDIKCIEKTRVILTTDGaSSDYIHANYVGISIKP-KKFICTQGPKDS
.||  .|  .|. || |||.|| ..|.   |..   ||..|        ||||.|. | ... | |      ||||||||||  . | |.|||.||| | 
piveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldq

TIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYvsKGHTITINNLGVGTLSpDDDFINVTNLELVW-AGKTRSITHYQWTNWPDHGAP
|| .|| ||||..|| |.|||| .|| ..|| |||||  |.  .   |.  .  |  |   .   |  |..| |.| .  ... |. | |||.||| | |
tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel..ksgivvenvsgskpme.rdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp

PINMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTK
| .. ...|. |.     |.|||||||.||.|||| |  |..|. .  .|  | .||  .|.|| ..||.. ||..||||.|.|||| .|| |  || ..
pckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaalltae

N
|
n
0051299 (Phosphotyrosine protein) phosphatases II 51-326 5.8e-81 267.4 In-house 8-286 (288) alignment 
Range on Protein: 51-326
Range on HMM: 8-286/288.0
SIVRPWVHHTLNKGVSKLRDEFSEVANKNPNVP--VDAFKSNPEKNRYTDIKCIEKTRVILTTDGA--SSDYIHANYVGISIKPKKFICTQGPKDSTIYD
. .. .|...| .|...|..|| |. ...|...  . ... | |||||.|| . ...||.|.. .   .||||.|.|. .  ...|||.||||...|..|
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWAMVIQDNVESIIMLCKVIELARVKCEQYWPAveGQTNTYvskgHTITINNLGVGTlspdDDFINVTNLELV------WAGKTRSITHYQWTNWPDHGA
|| || . ||. |.||.|..|| |.||.||||   |.. ||    . ||...| . .    .| . |..||..      . |..| .||...|||||||.
FWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggslty....gditvtllseev....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PPINMGAINLIEAVNYD----TNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
|.     ......|.       .||||||||||||.||.. . |... . .. .. |. ..|. .|.||....||. ||......||||.
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 51-327 2.2e-59 195.9 In-house 4-272 (288) alignment 
Range on Protein: 51-327
Range on HMM: 4-272/288.0
SIVRPWVHHTLNKGVSKLRDEFSEVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDgaSSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAM
 ..  |... |. .|  |  |. .  |....  .|.| .|| ..||... . . ||| |. |  .  ||.|| |  .  ....||.| | ..||  .| |
evinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsdd..pdfyiaanvvssakykrrlicaqaPlngtieelWkm

VIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTyVSKGHTITINNLgvgtlSPDDDFINVTNLELVWAGKTRS-ITHYQWTNWPDHGAPPINMGAIN
... .|| |.|||...|. . | ..|.| . |..   . .  |.. ..      .  |  ..|. |     |...  . .  . .|.|.| |   .  ..
llesdveyivmlcellekGkeksaeyfPsklGekar.igrlctvvkkkr.....adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr

LIEAVNYDTNPVVVHCSAGVGRSGTIVgISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
|.| ..  ..|.|||.||||||.||.. ..||. ....  .   ...|... |..|  ||||| ||.|.||..||..|
llevlkslqkPivvhssaGvGrtgtli.lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 52-328 2e-73 241.8 In-house 8-289 (305) alignment 
Range on Protein: 52-328
Range on HMM: 8-289/305.0
IVRPWVHHTLNKGVSKLRDEFSEVANKNPNVPVDAFKSN--PEKNRYTDIKCIEKTRVILtTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWA
 .  .|..||.||   || ||. .   |    . |||     .|||| |. |... || |       .|||||||    .||.||||| | . |  ||| 
qilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwy

MVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHTITINNLGVGTLSPDDD-FINVTNLELVWAG---KTRSITHYQWTNWPDHGAPPINM
| .||.||.|.|||...|    || .|... .... ..  ||. |..     .||.  .|   .||. .||  |   |.| .||| | .||| | |. ..
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl

GAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
  ..|.|       |.|||||||.||.|..| .  |.|....|   .| .|..  ||.||  .|||.|||...|.|.|.||..
ailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 52-349 2e-51 169.5 In-house 5-298 (312) alignment 
Range on Protein: 52-349
Range on HMM: 5-298/312.0
IVRPWVHHTLNKGVSKLRDEFSEVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDgaSSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMV
... |    .     .|  |.  | |  ..  . ||    . ||| .|.| .. |  |. |     |||||.| |  ||..|.||||| ..|.  || ..
mikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagd..enfyihanfvkictkperfvctqgplentcthfwqla

IQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHTITINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLI
.     |||.|| ..| .  || .|   . |  .    . .|    .. .|  | |     | .. .  .|.   . ||||. ||||| |     |  |.
lslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrll

EAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKmIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTKnYEEKYAK
 ||. | .||. ||||||||.||.. |  ..   ..    ...|.    .|..|  .... .||.|  |..||..        .    || ..| |||
savkkdkkpviahcsagvgrtgtlaliesmiaa.lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtk.fketyak
subfamily_PTPRB_pd Subfamily PTPRB 54-327 1.3e-62 206.5 In-house 13-286 (293) alignment 
Range on Protein: 54-327
Range on HMM: 13-286/293.0
RPWVHHTLNKGVSKLRDEFSEVANK--NPNVPVDAFKSNPEKNRYTDIKCIEKTRVIL--TTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWA
  .|... ..   .. .|..|. .   . .| ..  . | .|||||.|   ...|| |  ..| ..|||| |||.     |..|| ||||  .|. ||| 
eehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWr

MVIQDNVESIIMLCKVIELARVKCEQYWPAVegqtNTYVSKGHtITINnlgVGTLSPDDDFInVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAIN
|| ..... |.|| ...|  .||||.||||     .. |  |. |...   . . .  .|.. . .|..  . ..|....|..| ||||| |      ..
mvwekkssiivmltqlvekgkvkCeeYWPad....eepvlyGd.ikvt...lvaeeeledwv.irelkiekekeerkvrqyhftsWpdhgvPektktlld

LIEAVNY------DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
....|.       ...|.||||||||||.|| . .  ..... .  .. |.  .| |.|..| . .|||.||..||...|... 
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 56-324 1.6e-58 193.1 In-house 11-277 (288) alignment 
Range on Protein: 56-324
Range on HMM: 11-277/288.0
WVHHTLNKGVSKLRDEFSEV--ANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMV
.| ..  .. . . .|.  .   .|. .| .     | .|||| .|  .. .|| |.   ..|..||| |.|.  . | ||.|.||||  .|. ||| .|
kvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

IQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNtYvskGhTITINNLGVGTLspdDDFINvTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLI
 ..... |.|| ...|  . |||.|||. . ..| |   |  .|.  ... .|   .||..  .|.|.  .. . ||.||.. ||||| |  ..  ..|.
yenktstivmltelveggktkCeeYWPdadkpkn.y...G.svtvtlveskel...edfvl.rklllekkkteleitqyqylaWpdhgvPeskapllell

EAVN----YDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
. |.     ||.|..|||||||||.|| . .  ..|.. .  .  |.   |...|.||   .||. ||..|..|||.
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevlls
0040438 (Phosphotyrosine protein) phosphatases II 57-355 1.1e-80 266.6 In-house 9-305 (317) alignment 
Range on Protein: 57-355
Range on HMM: 9-305/317.0
VHHTLNKGVSKLRDEFSEVANKNPN-VPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGA--SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQ
.   |.... .|..|| .. . ...   | ... |..||||.|| . . .||.|. .|   .||||.|.|| .  ...|||.||||...|..||| || .
lldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvwe

DNVESIIMLCKVIELARVKCEQYWPAveGQTNTYvskgHTITINNLGVGTlspdDDFINVTNLELV--WAGKTRSITHYQWTNWPDHGAPPINMGAINLI
 .|..|.||..  || |.||.||||   |.| ||    ...|...|.. .    .. |....||..    ...| .||...|.|||||.||     ....
qgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

EAVNYD----TNPVVVHCSAGVGRSGTIVGISLIMDKMIQGInCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTKNYEEKY
|||.       .||.|||||||||.||.... |... . ..  . |... |.|.|.||..|.||..||......||||..  .. ..   | .| .....
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli

AKWLDDYN
 ..|||. 
plalddvk
subfamily_PTPN9_pd Subfamily PTPN9 57-330 5.5e-62 204.5 In-house 7-294 (297) alignment 
Range on Protein: 57-330
Range on HMM: 7-294/297.0
VHHTLNKGVSKLRDEFSEVANKNPNVPVDAFK--SNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVI
|..  .|| . |. |. |. |....  ..|.|  .| |||||||. |...||| |..  .   ||||.||.|    ..| || |||| . |. ||| || 
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

QDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVskghTITINNLGVGTlsPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIE
...|  |.|  .|.|  |.|| ||||  |.... ..     ....|. | .   .|  ..| ... |  ...|..||.| . |||.| |   .  ....|
eqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvsnvevee..eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

AVN-----------------YDTNPVVVHCSAGVGRSGTIVGISLIMDKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELH
.|                   .  |.|||||||.||.|| . . . .... . ..  |. . |. .|.|| ..|||. ||.. .  .||| |||.
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrl.eevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 57-331 8.1e-57 187.7 In-house 11-285 (318) alignment 
Range on Protein: 57-331
Range on HMM: 11-285/318.0
VHHTLNKGVSKLRDEFSEV-ANKNPNVPVDAF-KSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVI
|..  ..|  .|  |. ..  ...    ...  . |  ||||..|   ..||| |..  .  .|||| |||.    . |..| .|.|   || ||| || 
vrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

QDNVESIIMLCKVIELARVKCEQYWPAVegQTNTYvskgHTITINNLGvgTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIE
. |   |.|| .. | ...|...|||    ....|     .....     ... .|  .   ...     ..| .  |..|.|||.| |   .. ..|. 
eqnsavivmltqeeergkakvhryWPsk..gsrsy....gklvvelke..evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvr

AVNY-----DTNPVVVHCSAGVGRSGTIVGISLIMDKmIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHK
 |..     ...|.|||||||||| |. . .. .... |.  .  |. . |...|.||   .||| || .|. ||||.    ..
qvskaqqksgagpivvhCsaGvGrtGvfiavdiller.ikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 57-326 1.3e-56 187.0 In-house 14-283 (319) alignment 
Range on Protein: 57-326
Range on HMM: 14-283/319.0
VHHTLNKGVSKLRDEFSEVANKNPNVPVDA-FKSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQ
...  ..|  .|. || .. . ...    |  . | .||||..|. ...|||.|..  .  .|||| |...    . .||| ||.|.. || ||| || .
lkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

DNVESIIMLCKVIELARVKCEQYWPAVEgqtntYVSKGHTItINNLGVGTLspDDDFINVTNLELVWAG-KTRSITHYQWTNWPDHGAPPINMGAINLIE
...  ..||.|. |  .||...|||  .     ... |. | .. .    |  .|  |   .|.   .  .||...|.|.|.||||. |   .. ..|..
eessivvmltklveklkvklkkywpeen.....feeyGrli.vtleeeeel..edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllk

AVN-----YDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 ..      .  |.|||||||||| || . .. ..... .  .  |. . | ..| ||   .|...|| .|. .|||. 
rirksrektqsgPivvhCsaGvGRtGtfivldamlervkee.gvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 57-329 3.8e-47 155.5 In-house 11-286 (290) alignment 
Range on Protein: 57-329
Range on HMM: 11-286/290.0
VHHTLNKGVSKLRDEFSEV--ANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGASSD----YIHANYVGISIKPKKFICTQGPKDSTIYDFWAM
| .   || .. |..|  .  .... .| |.  .|| ..||...|   .  |..|   .   |    ||.| |.    . |..| ||||  .|. ||| .
vanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

VIQDNVESIIMLCKVIELARVKCEQYWPAVegQTNTyvSKGHTITINNLGVGTlSPDDDFINVTNLELVwaGKTRSITHYQWTNWPDHGAPPINMGAINL
. |..|  |.||...||  .||| ||||.   .|..      .|...|  . . .     ..|.| .    |...|.|.|| |||...|  . . . . .
iwqekvtiivmltniieegkvkCqqYWpds..dtka..ygefsikllneetln.eyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillv

IEAVNY-----DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLEL
|| ..        ...|||||..||||.. . .   ..|. .     |. ..... | |.   .||. || .|....|.|. ..
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckte.gvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 61-325 3e-58 191.8 In-house 22-282 (290) alignment 
Range on Protein: 61-325
Range on HMM: 22-282/290.0
LNKGVSKLRDEFSEVANKN-PNVPV--DAFKSNP--EKNRYTDIKCIEKTRVILtTDGASSDYIHANYVGiSIKPkKFICTQGPKDSTIYDFWAMVIQDN
 .|.| .|  |. |      |  ..  . |  |.  .|||| |. | .||||||  ||   ||.|||||   .|.  || |||.  .|. |.| ||.|..
vkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvil.kdGydGdyvhanyvk.Glka.mfiltqGalkdtvidiwrmvlqek

VESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSkgHTITINNlgvgTLSPDDDFIN-VTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAV
|  |.|||..||  . |||||.|  ||.. |. .   |..  .      ..|.. |  .  .  . .||   . |..   |||.  .  ..  . .. ..
vaaivmlceliedGkakceqyypekeGevltfGe..itvlcse....eddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril

NYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
   . |||||||||.||.||.| |   .. ...| .  |. .||  .|| |  ..| . ||. . ..||..
rkasGpvvvhcsaGiGrtGtfvaievglqilldGkel.dlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-326 5.8e-38 125.3 In-house 10-293 (301) alignment 
Range on Protein: 61-326
Range on HMM: 10-293/301.0
LNKGVSKLRDEFSEVANKNPN-VPVDAFKSNPEKNRYTDIKCIEKTRVILTTD----GASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDN
 .|   |. ....|. .....   |   ..| . ||. .|. ... |.||..      .. .|| |.|.    . |||| .||| ..|. ||| ...|. 
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

VESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHTI---------TINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGA---PPI
. ||.|...  | .. |||||||  | ......    |.         .| .| |      ..     ...   . ...... .| |.||..|    |  
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

NMGAIN--LIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 . .|.  ..     .  |||||||..|.|||. . .|. ..         |. .... .| ..  |..|  ||. |. |. .|.
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
0050432 (Phosphotyrosine protein) phosphatases II 62-327 1.7e-82 272.5 In-house 38-300 (308) alignment 
Range on Protein: 62-327
Range on HMM: 38-300/308.0
NKGVSKLRDEFSEVANKNPNVP--VDAFKSNPEKNRYTDIKCIEKTRVILttdGASSDYIHANYVGIS--IKPKKFICTQGPKDSTIYDFWAMVIQDNVE
 .. ..|. || |. .. |. .  | ... | .||||.|| . ...||.|   . .||||.|.|| .   ..|.|||.||||...|..||| || . ||.
aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

SIIMLCKVIELARVKCEQYWPAVEG-QTNTYvskgHTITINNLGVGTlspdDDFINVTNLELVW--AGKTRSITHYQWTNWPDHGAPPINMGAINLIEAV
 |.||.| .|  |.||.||||  .| .. .|    . .|...| . .    .| . |..|||..   |..| .||...|||||||.||     ....|.|
vIvmLtklvengrekcaqYwplelgggsley....gkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

NYD--TNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
.     .|.||||||||||.||.. . |... . .. .. |. ..|  .| ||....||. ||....|.||||..
rkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 62-326 7.1e-55 181.3 In-house 23-290 (298) alignment 
Range on Protein: 62-326
Range on HMM: 23-290/298.0
NKGVSKLRDEFSEVANKNP-----NVPVDAFKSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQD
.|..... .|| .. . .      .  |   ..| .||||.||  ....||.|..  .   |||| | ..    . . || ||.|  .|. ||| ||...
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvtee

NVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKghtitinnlgvgTLSPDDDFINVTNLELVW----AGKTRSITHYQWTNWPDHGAPPINMGAINL
....|.|| .. || ..|...||| .. .|   ..             .|  ...| .... .|        |.|.. . ..|.|||.|.|  .   ..|
digtiVmltnleeldktkyhkywPdegketygeitv............sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IEAVNY---DTN--PVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.. |.    ..   ||.|.|||||||||| . |. ..... .  .  |. . |. .|..|  |.|||.||..|. . ||..
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPRG_pd Subfamily PTPRG 62-328 8.3e-53 174.4 In-house 15-289 (563) alignment 
Range on Protein: 62-328
Range on HMM: 15-289/563.0
NKGVSKLRDEFSEVANKNPNVPVDAFK----SNPEKNRYTDIKCIEKTRVILT-TDGASS--DYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQD
 .|  ..  || .. ..  .  .|| .    .| .||||..|  ....|| |. . |  .  ||| |||.    | |.|| ||||  .|. ||| |. . 
adgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

NVESIIMLCKVIELARVKCEQYWPAvEGQTNTYVskgHTITINNLGVGTLSPDDdFINVTNLELVWA---GKTRSITHYQWTNWPDHGAPPINMGAINLI
||. |.|. .. |  | ||..|||. ..  .  .    ..|. .  | .|.     . . ||.|       . . ...|..|.|||||.|  ..  .. .
nvaiivmitnlvergrrkcdvYWPk.desetyga...lqvtlieeevlalytvr.tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifv

E---AVNYD-TNPVVVHCSAGVGRSGTIVGISLIMdKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
.   | | . . |.||||||||||.|| . .. .. | ||  |  .. ...  || || . .||| ||...| .|||  . 
kkssaankaeaGPivvHcsaGvgrtGtyivldtll.kqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN23_pd Subfamily PTPN23 62-325 6.5e-49 161.3 In-house 11-279 (288) alignment 
Range on Protein: 62-325
Range on HMM: 11-279/288.0
NKGVSKLRDEFSEVANK----NPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTtdGASSDYIHANYV-GISIKPKKFICTQGPKDSTIYDFWAMVIQDNV
 .|...|  .| |. .|    . .  . . | ..||||..||   ...|| |   |   ||| | .| ..|    .||.||.|..||. ||| || .. .
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

ESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSkgHTITINNlgVGTLSPddDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY
. |.|| .  || . |...|||. .|.|...     ..|...  | ....      | .||   | ...|..| |.|.||..|.|      ......|. 
sviVmllskeelgkpkvdrYwPedkgetvkfgd..lsvtlks..vretet..hvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

--------DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
           |.||||||||||.|..  .  .. .. .|    |. ..|. .|.||.. .|...|.     . ||.
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 62-332 1.8e-47 157.2 In-house 30-297 (319) alignment 
Range on Protein: 62-332
Range on HMM: 30-297/319.0
NKGVSKLRDEFSEVANKNPNVPVDAF---KSNPEKNRYTDIKCIEKTRVILT-TDGA-SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNV
.. ..||. ||  .... .|    .|   . | .|||...|   .|..| |  ..|   |||| | .|    ...|.| .|||.| |. ||| |. . |.
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

ESIIMLCkvielaRVKCEQYWPAVEGQTNtyvSKgHTITINnlgvgTLSPDDDfINVTNLELVWAGK---TRSITHYQWTNWPDHGAPPINMGAINLIEA
 .|..|       . || ||||    ...    .   . ..     ..   ..   | ..||   ||    |.|| . .  |||.| |   .  . |.. 
stivllt......kdkcsqywplkivike...er.fkvkvd.....sveetae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

VNY------DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKE
|..      . ...||||||||||.|. . .  ..|.| .  .  |. ..|...|.||   .|  .||..|.  ||| .|  | .
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee.kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 63-326 5.9e-58 191.4 In-house 19-283 (305) alignment 
Range on Protein: 63-326
Range on HMM: 19-283/305.0
KGVSKLRDEFSEVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGASS--DYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESII
.  ..|  .. ......  . |.  . | .|||...|   .. |.|||..      ||| |.||    . ||.| .||| ..|. ||| ....  |..|.
ysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLCKVIELARVKCEQYWPAVEGQTNTYvsKGHTITINNLgvgtlSPDDDFINvTNLELVW---AGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYD
||.|..|  . ||.||||  ..... .     ......      .   |.|.  .|..       ..|....|| |.||||| |      ..||. |. |
mltklveggkdkCrqYWpesktekkef..gefsvelkse.....ktasdyie.RklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd

T----N-PVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
     . |..|||||||||.|. . ... .... .  .  |. ... ..|..| ...|| .||...| .| |. 
qkkdkgvpllVhCsagvgRtGvfiavdialerlkkE.evvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_ptpA1_pd Subfamily ptpA1 63-287 3.1e-39 129.9 In-house 18-258 (418) alignment 
Range on Protein: 63-287
Range on HMM: 18-258/418.0
KGVSKLRDEFSEVANK-NP-NVPVDAFKSNPEKNRYTDIKCIEKTRVILT--TDGASSDYIHANYVGiSIKPKKFICTQGPKDSTIYDFWAMVIQDNVES
| . |...||  . .   | .      | |  |||||.|  ...||| |    |   |||| |||.     ||.|||||||   || ||| || .. .  
kcihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcri

IIMLCKVIELARVKCEQYWPAVEG-QTNTYVSKGHTI-TINNLG-VGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN
|.|| .  | .|.||..|||   | .  .   .|  .    ..  |  .   .  |   |. | . |.|| ||.||.  ||||  |       .|. .. 
ivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit

Y---------D-TNPVVVHCSAGVGRSGTIVGISLIMDKMIQ
          |   |..|||||||||.||..   ..| |. .
nrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 64-326 2e-45 149.9 In-house 7-266 (283) alignment 
Range on Protein: 64-326
Range on HMM: 7-266/283.0
GVSKLRDEFSEVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDgaSSDYIHANYVGISI---KPKKFICTQGPKDSTIYDFWAMVIQDNVESII
.    |. . ...  . .. ... . |..|||. .|   .. || | ..  | ||| | .. .|    . ||.| .|.| | |. ||| || .... .|.
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelkse..srdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MLCKVIELARVKCEQYWPAvEGqTNTYvsKGHTITINNLgVGtlspDDDFINvTNLELV---WAGKTRSITHYQWTNWPDHGA-PPINM-GAINLIEAVN
|| |. |  |.|| ||||  .| .  |     |.|...  ..     . ||   .| |     | .|  ..|||  .| . |  ..||    .|.. .  
mltklqedlrikCsqyWPk.rG.sedy..Geftvtlrke.tt....snsfii.kelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislq

--YDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
      |.|||||.|.||... ...|  ....       |. . |. .|.||  |.||  ||. .| . ||  
teskkgPivvhCstgiGrtavfiaasasvkdalte.svvdvfavvkimreqrmmavqtldqyklvhelvleqa
0036941 (Phosphotyrosine protein) phosphatases II 65-328 5.4e-82 270.7 In-house 12-279 (297) alignment 
Range on Protein: 65-328
Range on HMM: 12-279/297.0
VSKLRDEFSEVANKNPNVP--VDAFKSNPEKNRYTDIKCIEKTRVILttDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIML
 ..|. ||.|. .  .. .  | ... | |||||.|| . ..|||.|  |. .||||.|.|| .   ..|||.||||...|..||| || . ||..|.||
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

CKVIELARVKCEQYWPAVEGQTNTYvskgHTITINNLGVGTLspDDDFINVTNLELVW--AGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY----
....|| |.||.||||  ||.. ||    . .|...|.| .   ..| . ...||..    |..| .||...|.|||||.|.     ...||.|.     
telvelgrekcaqywpleegeslty....gdftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQ--GINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
  . .||.||||||||||||.... |... . .    .. |....| ..|.||. |.||. ||......|||... 
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
0047943 (Phosphotyrosine protein) phosphatases II 65-326 1.1e-79 263.1 In-house 11-272 (273) alignment 
Range on Protein: 65-326
Range on HMM: 11-272/273.0
VSKLRDEFSEVANKNPNVP--VDAFKSNPEKNRYTDIKCIEKTRVILttDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIML
...|. || .. .  |...  | ... | .||||.|| . ...||.|  .. .||||.|.||    ...|||.||||...|..||| || . ||. |.||
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

CKVIELARVKCEQYWPAVEGQ-TNTYvskgHTITINNLGVGTlspdDDFINVTNLELVW--AGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY---
....|| |.||.||||  .|. . ||    . .|...|.. |    .| . |..|||..   |..| .||...|.|||||.||     ...||.|.    
telvelgrekcaqYwpleggelslty....gkftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

---DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
   . .||||||||||||.||.. . |..| .. . .. |....|  .|.||....||. ||......||||.
alpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 65-328 2.8e-28 93.2 In-house 25-287 (302) alignment 
Range on Protein: 65-328
Range on HMM: 25-287/302.0
VSKLRDEFSEVANKNPNVP-VDAFKSNPEKNRYTDIKCIEKTRVILTTdgASSDYIHANYVGIS-IKpKKFICTQGPKDSTI---YDFWAMVIQDNVESI
 .....|| ....   ..    |||.|..||. .|........|.|..  .  .|..|  | .  .. .. | .| || ..     .|| || |... |.
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvklea..epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsv

IMLCKVIELARvKCEQYWPAVEGqtnTYVSKgHTITINNLGVGTLSPDDdfiNVTNLELVWAGKTRSI--THYQWTNWPDHGAPPINMGAINLIEAV---
 .| .  || .   ....|   |   .|.    .. .||  |   . .    .   .|..  | . |.  . |  |||...  |     .|. .. |   
vilvgeeelkk.tlselfpkksg...dykey.gkmfvNnrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfak

NYDT-NPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
. .. ...|.    |.|| |...   . ..|. .| .   .| .|. ||.||  |...  ||. ....|| |...
kikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 66-326 6.8e-54 177.8 In-house 5-268 (274) alignment 
Range on Protein: 66-326
Range on HMM: 5-268/274.0
SKLRDEFSEVANKNPNVPVDAFkSNPEKNRYTDIKCIEKTRVILTTDGAS---SDYIHANYV-GISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIM
 .|..|| |.    ..  .| |  . .||||..|   |..||.|... ..   |.|| |||. | . . | .. ||||  .|. ||| |. |..|. |.|
kdlekeflelPlnfdqeeldvf.gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

LCKVIELARVKCEQYWPavegQTNTY-VSK-GHTITINNLGVgtlSPDDDFiNVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY---
| |. |  . ||..|.|    ... | .|.    . |.. ..      .|. .|..| |  . ..||..|| .|.|||| .|      ..|.. |.    
ltklkeaneqkCavyfP....daedyeiserygdveikveki...verndy.svrklvlkylerersvkhywytdWPdhksPddantlldlvleveesre

----DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGInCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
     . |||||||||.|| |  ..||. . .. . |   |. |.| ..| .|   .||. || .|||.| .| 
eenaklapvvvhCsaGiGrtGcfiaisiavrqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPRA_pd Subfamily PTPRA 66-328 1.1e-53 177.3 In-house 32-297 (330) alignment 
Range on Protein: 66-328
Range on HMM: 32-297/330.0
SKLRDEFSEVAN--KNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTT-DG-ASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIM
 ..|.||  .     .  . . . . | ||||. .|   . .||||.. .|  .|||| | ..    . .||| .||||. |. ||| |. . .  .|.|
klfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativm

LCKVIELARVKCEQYWPAvEGqTNTYVSkgHTITINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN----YD
| .. |  . ||.||||  || . ||     ......  |       .|.     .     |.| .. . .| ||| | |   .| ..|...|.      
ltelkerkeekcaqywPd.eG.lvtyGn..irvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqs

TNPVVVHCSAGVGRSGTIVGISLIMDKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
..|.||||||||||.|| . .. ..... .  .  |. . |...|.||   .||. || .|..|||||.| 
agpivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 67-326 6.6e-59 194.3 In-house 16-276 (281) alignment 
Range on Protein: 67-326
Range on HMM: 16-276/281.0
KLRDEFSEVANKNPNVPVDAFK--SNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIML
 .  |....|. . . .  | |   | .||||..|   ..||| .|   .  ..||| ||.|    ..|..| ||||  .....|| ||.. .|. |.|.
GfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

CKVIELARVKCEQYWPavEGQTntyvskghTITINNLGVGTLSPDDDFINV-TNLEL-VWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAV----NY
 . ||  ..|| .|||  ....        .... .. | ...  .    .  ...|    |.||.... ..|.|||||.|   .  ..  ..|    . 
treieagklkChrYWP..ddns........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltek

DT-NPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.|  |.|.||||||||.|| ...  ..... .  .  |.| .|.|.|..| . .|| .|| ......|...
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 67-329 3.3e-50 165.3 In-house 12-272 (281) alignment 
Range on Protein: 67-329
Range on HMM: 12-272/281.0
KLRDEFSEVANKNPNVPVDAFK--SNPEKNRYTDIKCIEKTRVILTT---DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIM
 ...|||..    |   . .|.   | .||||..| |.. .|| |     .  |.|||||||.   .  . .| |||||  |  ||| |. |.|  .|.|
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LCKVIELARVKCEQYWPAvegqtNTYVS-KGHTITINNlGVGTLspdDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDTNP
||...|  | || .|.|      |...  .   ....     |.   .  .  | |.| . |.|| |||. | .|||   |      ....  .   . |
lcqfletnrekcaeyfpr.....nahcclqfdklsvsy.edstv...nkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstp

VVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRN-QRHYAIQTEAQYMYIHRVLLEYFLEL
 |.|||||||||||.. . . .. .   .   |.|..|  .|   |  ..||  ||| | .|||.. .  
pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
subfamily_PTPN14_pd Subfamily PTPN14 67-326 5.8e-42 138.7 In-house 24-296 (300) alignment 
Range on Protein: 67-326
Range on HMM: 24-296/300.0
KLRDEFSEVANKNPNVP--VDAFKSNPEKNRYTDIKCIEKTRVILT-TDGASSDYIHANYVGISIK--PKKFICTQGPKDSTIYDFWAMVIQDNVESIIM
|.  |. ....|. .    . . . | ||||. |.   |..|| |. |  .|..|| |  . .|.    ...| .||| . |. ||| || ...|. |.|
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LCKVIELARVKCEQYWPAVEGQTNTYVSKGHTITINnlgvgtLSPDDDFINVT--NLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN---Y
| . .|  . |. .|.|  | . .|   . . .| .      .| | | .  |  .|. . ... |.. | |.|.||||| |.   | .. .| |.   .
lteeeedgkeksfkyfPkleskkktvefgkfkvttk......fsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrr

DT----------NPVVVHCSAGVGRSGTIVGISLiMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 |           ||.|||||||||.| ..   | . . ..  .  |.|| .. .|.|| . .|| ||| ....||..|.
ktnseveskeskPPvlvhCsaGvGrtGvlilsdl.liatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0046845 (Phosphotyrosine protein) phosphatases II 68-328 1.1e-79 263.0 In-house 2-276 (284) alignment 
Range on Protein: 68-328
Range on HMM: 2-276/284.0
LRDEFSEVANKNP----NVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGAS---SDYIHANYVGIS-----IKPKKFICTQGPKDSTIYDFWAMVIQDN
|..|| |. . ..    .. | ... | .||||.|| . ...||.|.. . .   ||||.|.||        ...||||.||||...|..||| || . |
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VESIIMLCKVIELARVKCEQYWPAVeGQTNTYvskgHTITINNLGVGTlspdDDFINVTNLELVW---AGKTRSITHYQWTNWPDHGAPPINMGAINLIE
|. |.||.. .|  |.||.||||   |.. ||    . .|...| . .    .| . |..|||..    |..| .||...|.|||||.||     .....
vrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

AVNYD------TNPVVVHCSAGVGRSGTIVGISLIMDKMIQGIN--CKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
.|.         .|.||||||||||.||.. . |... ....    . |. ..|  .|.||....||..||......||||.. 
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPN3_pd Subfamily PTPN3 68-324 2.3e-52 172.6 In-house 17-273 (280) alignment 
Range on Protein: 68-324
Range on HMM: 17-273/280.0
LRDEFSEVANKNPNVPVDAFK--SNPEKNRYTDIKCIEKTRVILTTDGAssDYIHANYVGISIKP----KKFICTQGPKDSTIYDFWAMVIQDNVESIIM
.  .| ..  |.|.. ..| .   | .|||| ||   ..|||.|.   .  ||| |||| . |      ...| |||| ..|  ||| || ..... |.|
vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LCKVIELARVKCEQYWPAvEGQTNTYVskGHTITINNLGVGTLSPDDDFInVTNLElvwAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY----D
|  ..|  |||| ||||  .... .|   . ......    .     ... ... |   . . |.|.. |...||||| |  .   ....| |.     .
lttlverGrvkChqyWPe.tedeleyg..efsvkcekedetksyvlrelv.lkdke...tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk

TNPVVVHCSAGVGRSGTIVGISLIMDkMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
..|||||||||.||.| .. . . .  .|.  .   . ..| ..|.||   .||..|| ..   .|.
eePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 68-324 2.5e-36 120.1 In-house 22-277 (439) alignment 
Range on Protein: 68-324
Range on HMM: 22-277/439.0
LRDEFSEVANKNPN----VPVDAFKSNPEKNRYTDIKCIEKTRVIL--TTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIM
....| ..   .|.      . | . .  |||| |.   . |||.|  .     | || |||.    ..| .| |||||. |  ||| .||. ..  |.|
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LCKVIELARvkceqYWPAVEGQT--NTYVSKGHTITINNLGVGTlspdddfINVTNlELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY---
|....|  .     |||. .     .  |   . | . |  .         ..| | |   . | |.. ..... |||.  |      .... |.|    
ltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirg.......fkvfn.erdttekertvlqfhyiawpdknvpaqashvldflrainsand

--DTNPVVVHCSAGVGRSGTIVGISLIMDKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
  .. ||||||||||||.|||. . . .... .  |  |.| .|. .|.||.  .|. .||..|.  .||
keeygpvvvhcsagvGrtGtiialdialeql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
DSPc_SM00195 69-326 4.6e-81 267.4 In-house 3-262 (263) alignment 
Range on Protein: 69-326
Range on HMM: 3-262/263.0
RDEFSEVANKN--PNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDG--ASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCK
. ||... ...   ..   ..|.| .||||..|.....|||.|...    .||||.|||. .. |.||.|.||||..||. ||| ||.. .|. |.||..
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VIELARVKCEQYWPAVEGQTNTYVskghTITINNLGVGTLSpddDFINVTNLELVWAG--KTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDTN---
  |  . ||..|||  .|...|.     .|....  | . .   | |....|||   |  .||..|.||..||||||.|  ..  ..|..||. ...   
eeengkekcdrywpeesggketfg....kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

-PVVVHCSAGVGRSGTIVGISLIMDKMIQGINcKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 |.||||||||||.||.| |..|..|. .. .  |....|.|.|.||. ..||..||..|....|||.
gpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 69-326 4.6e-81 267.4 In-house 3-262 (263) alignment 
Range on Protein: 69-326
Range on HMM: 3-262/263.0
RDEFSEVANKN--PNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDG--ASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCK
. ||... ...   ..   ..|.| .||||..|.....|||.|...    .||||.|||. .. |.||.|.||||..||. ||| ||.. .|. |.||..
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VIELARVKCEQYWPAVEGQTNTYVskghTITINNLGVGTLSpddDFINVTNLELVWAG--KTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDTN---
  |  . ||..|||  .|...|.     .|....  | . .   | |....|||   |  .||..|.||..||||||.|  ..  ..|..||. ...   
eeengkekcdrywpeesggketfg....kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

-PVVVHCSAGVGRSGTIVGISLIMDKMIQGINcKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 |.||||||||||.||.| |..|..|. .. .  |....|.|.|.||. ..||..||..|....|||.
gpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 69-325 1.4e-54 180.2 In-house 14-268 (273) alignment 
Range on Protein: 69-325
Range on HMM: 14-268/273.0
RDEFSEVANKNPNVPVDAFKS--NPEKNRYTDIKCIEKTRVILTTDGAssdYIHANYVGISIKPKKF--ICTQGPKDSTIYDFWAMVIQDNVESIIMLCK
 .|| |. .  |   ..  |.  | .|||| ..  ...|||.|  .|.   || |... . .  ...  | .|||   |. ||| || . ..| |.|. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl

VIELARVKCEQYWPAVEGQTntyVSKGHTITINNLGVGTLspDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAV---NYDTNPV
  |  .|||..|||  ....   .     .....|.|  |  |.  ..  ... . .|..| ..| ....||||| |   .  ....  |   . |. |.
ekekgkvkchrywPesknkk...lkvsnrlevellkvqkl..dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPi

VVHCSAGVGRSGTIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
|||||||.|||||.. |  ... . .  .  |.|..|...|.||.  .||. ||.......|| 
vvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 69-327 1.3e-50 167.0 In-house 21-277 (515) alignment 
Range on Protein: 69-327
Range on HMM: 21-277/515.0
RDEFSEVANK--NPNVpVDAFKSNPEKNRYTDIKCIEKTRVIL--TTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCK
 .|| ..      |.  |   . | .|||| .|  ....||.|    |   |||. | |.      | .|..|||..... ||| .|.|.||  |.|. |
seefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

VIELARVKCEQYWPAVEGQTNTYvskGhTITINNLgvgTLSPDDDFINvTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDTN----P
  |  ..|| .||| . |..  .   | .| .. .   .|. . . |   .|...   ..| .| ...|.|||.|.|.     . || .|  |..    |
lkegdkikcgkyWPdkpgdsvkf...G.sikvelv...sleactggik.rkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythp

VVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
...|||||||| | .. |  .. .. .. .  |. ..|. ||..| | .||. || .|. ..||..|
liihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0043336 (Phosphotyrosine protein) phosphatases II 70-326 5.1e-74 244.5 In-house 24-277 (278) alignment 
Range on Protein: 70-326
Range on HMM: 24-277/278.0
DEFSEVA---NknPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGAS--SDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCK
 || |.       ..  . ... | .||||.|| . . .||.|. .|    ||||.|.||    .|.|||.|||| ..|..||| || . .|..|.||..
lefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

VIELARVKCEQYWPaveGQTNTYvskgHTITINNLGVGTlspdDDFINVTNLELV--WAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY----DT
  || |||| ||||   |.. ||    ...|...|.. .    .| . |..||..    |..| .|||....|||||.|.     .....||.     . 
lvelgrvkcaqYwp...ggslty....gdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsn

NPVVVHCSAGVGRSGTIVGISLIMDKMIQGInCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.||.|||||||||.||.... |... .  .  . |. . |.|.|.||. |.||. ||......||||.
gpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 70-328 2.1e-22 74.1 In-house 26-281 (303) alignment 
Range on Protein: 70-328
Range on HMM: 26-281/303.0
DEFSEVAN-KNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTtDgasSDYIHANYVGISIKpKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIEL
.|| .|..   |.|  . | .| .|||..|. |.....| |. |   | ||||.|. .  . || | || |   |  ||| |.|...|  ...|    | 
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls.d...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdsey

ARVKCEQYWPAVEGQTNtyvSKGHTITINNLGVGTLSpDDDFINVTNlelVWAGKTRSITH-YQWTNWPdHGAPPIN-----MGAINLIEAV---NYDTN
 ..  .  .|  .   .    .  .| . ..    |. |   ..|     |  |. .|. | ... .|| |.. | .     .  |  ...|     |..
dklggdsvfprnqdflk...feersirvgefkrvelg.dgwvlkvls...vsngdyksflhvhhykawp.hnsipsdgspkfvkqiwqlqsvlrkysdst

PVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
| |    .|.||.||.  .      . .  .. |. | .| .|| | .|.|  .|. ... .| |. |.
ptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Ptp69D_pd Subfamily Ptp69D 71-326 4.7e-53 175.3 In-house 27-286 (307) alignment 
Range on Protein: 71-326
Range on HMM: 27-286/307.0
EFSEVANK--NPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVI
|. .. ..  . .  | . | |  |||| |||  .||||.|..    ..|||| |...    . ||||. |.| ..|| ||| |. . .|. |.|| .. 
eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlt

ELARVKCEQYWPAVegQTNTYVskghTITINNLgvgTLSPDDDFI----NVTNLELVW--AGKTRSITHYQWTNWPDHGAPPINMGAINLIEAV----NY
|  | ||..|||    ..  |      | ..       .  .|.|    .|.. .       ..| .. |..|.|.|  .|    | ..||| |    . 
eknrkkcakYWpie..devqyg....dilvklv...seekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.  |.||||||||||||..| ........ .  .. |. . | ..|.||   .|  .||....| ||.| 
nrsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 71-326 8.5e-43 141.4 In-house 28-278 (287) alignment 
Range on Protein: 71-326
Range on HMM: 28-278/287.0
EFSEVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTtdGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELAR
 . .| ... .| ..  ..| .|||.|.|   .. ||.|   |   ||| | ..    . |.|| ...|  .|. .|| .. . ||. |.|||.  |  .
vleqvtqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekende

VKCEQYWPAVEGqtntYVSKGHTITINNLGVGTLSPdDDFINVTNLElvWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY-----DTNPVVVHC
 .| ||||  .      |   ..|.. |  | .       ..|.| .   ||...... || |||...|  .     . .||  .         ..||||
evcyqyWpeeks....vvlGeyniellneevnagyi.erklevknkn..kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

SAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
|..||||.. . .   ..|  .     |. ..... | |.  ..|| .||..|  ..||| 
sdtvGrsamfcaaattinkckt.eGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 74-325 1.8e-31 104.1 In-house 17-258 (267) alignment 
Range on Protein: 74-325
Range on HMM: 17-258/267.0
EVANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDgaSSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIElarVKC
...... ..     . | |.||. |    ..||||| |     .|| | ||    . ..|| ||.| . || ||. .... .|  |..| || .    . 
kisdtsstisqsiaeknqernrlddnlpyddtrvilrtk..eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft...dni

EQYWPAVEGQTNTYvskgHTITINNlgvgTLSPDDDFINVTNLELVWAG-KTRSITHYQWTNWPDHGAPPINMGAIN---LIEAVNYDTNPVVVHCSAGV
 ..||   ||.. |    . .|..     .|  ...  ..  ||| .    .. .| | . .|         .  .      . ..   .|.||.||.||
rlfwPPkmgqakky....qdltveh....slekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGv

GRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
||||| . |   .... .  .  |. ... .||.||   ..|  .|.|||..| ||
GrsGtflvidsqlerakte.gvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 75-242 5.2e-14 46.4 In-house 80-237 (244) alignment 
Range on Protein: 75-242
Range on HMM: 80-237/244.0
VANKNPNVPVDAFKSN-PEKNRYTDIKCIEKTRVILTTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIElarvkC
.   .|.|  |||. |   |||      ..  || |.    .  || | .||   .  ..| || |   |  ||| |...  |. ...|  | |      
iirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....e

EQYWPAVEGQtNTYvSKghTITInnlgvgTLSPDDDFINV--TNLELVW--AGKTRSITHYQWTNWPDHGAPP
..|||  |   . |  .   ||.      ||.  |.| |.  .|||.        ...| .| .|||  |. |
deywpdsepl.ewy.ee..ditv......tltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 76-327 8e-45 148.0 In-house 21-271 (285) alignment 
Range on Protein: 76-327
Range on HMM: 21-271/285.0
ANKNPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDgaSSDYIHANYVGISIKPK-KFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCE
    ||.   |...||. |||.|..|||.|||.|       |||||... .  | .  .| ||||   |. ||| |. |...  ..||| ..|    || 
gymppnctytayeanpdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

QYWPAVEGQTNTYVSKGHTITIN--NLGVGTLSpddDFINVTNLELVwAGKTRSITHYQWTNWPDHGAPPINMGAINL---IEAVNYDTNPVVVHCSAGV
 |.|   |.   .     |.|    .   ||.    . . |.| |   . .   . | |   |||. ||      |.|   .. ||   .|..|||||||
lyypeklgevvkfgkyeitlteckeeaiagtil...naltvinteda.sseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagv

GRSGTIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
||. |.|||     ....  |  .|  .| |.|  |  |.|.  |..... ||.|||.
grtatfvgidyatirimenpni.emldivremramrfqavqshmqflflyvvlmeyfi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 76-167 5.7e-08 26.6 In-house 21-112 (332) alignment 
Range on Protein: 76-167
Range on HMM: 21-112/332.0
ANKNPNVpVDAFKSNPEKNRYTDIKCIEKTRVILTTDGASSDYIHANYVGISIKPKKFICTQGP-KDSTIYDFWAMVIQDNVESIIMLCKVIE
|   ||   | |  | . ||   . |....|| |. .    |.  |..|    |   .| .| | .| | | || || . .   |...  . |
amtypnt.ydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 79-166 1.9e-10 34.8 In-house 26-120 (347) alignment 
Range on Protein: 79-166
Range on HMM: 26-120/347.0
NPNVPVDAFKSNPEKNRYTDIKCIEKTRVILTTDGA-------SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVI
 ... .  .. . .|||  | | |..|||.|. . .       .  || | .. .    |..| || |  .|. ||| ||   .|  .. . . |
pskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
0045098 (Phosphotyrosine protein) phosphatases II 81-328 1.2e-72 240.0 In-house 24-274 (278) alignment 
Range on Protein: 81-328
Range on HMM: 24-274/278.0
NVPVDAFKSNPEKNRYTDIKCIEKTRVIlttdgassDYIHANYVGISikPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPav
 . .  . .| .||||.|| ... .||.        |||.|.|. .   |||||.||||..||. ||| |. . ....|.||....||.|.||.||||  
eitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp..

EGQTNTYvskgHTITINNLGVGTLspDDDFINVTNLELV----WAGKTRSITHYQWTNWPDHGAPPIN--MGAINLIEAVNY-----------------D
||.. ||    . .|...| . .|  ||  . . ... .      ...| .||.....|||||.|. .  .  ..|.| ..                  .
eggslty....gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

TNPVVVHCSAGVGRSGTIVGISLIMDKMiqGiNCKDMKKLVEEIRNQRHY-AIQTEAQYMYIHRVLLEYFLE
 .||.|||||||||.||.|.. |... .  . .  |. . |.|.|.||.. |.|.. ||......|||..| 
ggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_CG42327_pd Subfamily CG42327 81-248 1.1e-20 68.6 In-house 23-184 (319) alignment 
Range on Protein: 81-248
Range on HMM: 23-184/319.0
NVPVDAfksnPEKNRYTDIKCIEKTRVILTTDG--ASSDYIHANYV-GISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYW
.||| .     .|.|. ..  . .|||.|   |   .. |..|.|| |    |  .|..| . ...  ||| .| . .   |. |... ||   .| .|.
evPvts....kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeyl

PAVEGQTNTYVSKGHTITINNLGVGtlspDDDFINVTNLELVWAGKTRSITHYQWtNWPDHGAPPINMGAI
|. |.  || .     .|. .  |.    |  .|    |  |   ..| .||| . .|.. . |  .   |
PtketldntslyGdilvtlkgrevk....dryaistlllkrvdkeesrelthywy.kwleaevPaeeaali
subfamily_PTPN1_pd Subfamily PTPN1 82-332 1.2e-47 157.0 In-house 24-277 (290) alignment 
Range on Protein: 82-332
Range on HMM: 24-277/290.0
VPVDAFKSNPEKNRYTDIKCIEKTRVILTTdgASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVE
. .  ...| ..||| |..  ...|..|    |. ||| |. | .    ...| ||||  .|.  || || ...  ...|| ||.|  ..|| ||||  |
treaklpenrnlnryrdvspydhsrikler..adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

GqTNTYVSKGHTITINNLGVGTLSpdDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAV------NYDTNPVVVHCSAGVGRSGTI
  ... . .  ..... .   . |     ... .|| . . .||.|.|. .| ||| | |      ....  |      . |  |.|.|||||.|||||.
e.ekellledtklkvkliseerks..yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

VGISLIMDKMIQG--INCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKE
. .  .. .. .   ... |.|| . |.|..|.  |||  |  . .  .||    ....
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgd
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 83-195 1.4e-06 20.0 In-house 22-123 (275) alignment 
Range on Protein: 83-195
Range on HMM: 22-123/275.0
PVDAFKSNPEKNRYTDIKCIEKtrvILTTDgASSDYIHANYVGISIkpKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIElarvkCEQYWPAVEG
 .. |  | ||||.|.. |...   ||  .     ..||| .  .    .|. .| |.|||  |.  ..   ||.... |    |     .  |.   ||
kierfirngeknrftnvtcfde...ildre.nqeffvhantfrtpy..gnflisqapndstnadhlhllwiynvqtvvclvlpee.....aggyfvpkeg

QTNTYVSKGHTIT
.| |   |    |
etftsfqkyqikt
0040439 (Phosphotyrosine protein) phosphatases II 84-327 3.6e-71 235.0 In-house 5-247 (249) alignment 
Range on Protein: 84-327
Range on HMM: 5-247/249.0
VDAFKSNPEKNRYTDIKCIEKTRVILTTDG--ASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAve
|  .. |..||||.|| . . .||.|.  .    ||||.|.|.  .  ...||.|||| ..|..||| |. . ....|.||..  || |.||.||||   
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

GQTNTYvskgHTITINNLGVGTlspdDDFINVTNLELV--WAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY------DTNPVVVHCSAGVGRSG
|.. .|    ...|...| | .     | . |..|||.    |..| ..|.|.|.|||||.||    ....||||.       . .||.|||||||||.|
ggsley....gdftvtllsvev....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
|.... |... .    .. |..  |...|.||..|.|.. ||......|||..|
tfiaaylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 84-326 3e-56 185.4 In-house 14-264 (270) alignment 
Range on Protein: 84-326
Range on HMM: 14-264/270.0
VDAFKSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYV-GISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAV
. ..  ... |||.||    .|||.| .  .   . || |||| |.. ..||.|...||...|. .|| |... .|..|.|. .. |  | |||.|||| 
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

EGQTNTYvSKGHTITINnlgvgTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINM------GAINLIEAV-----NYD-TNPVVVHCSAG
 ... .. ..|.  ...     . .  ...  .|.|.|   |..| ..|.....|||||.|. .         .....||     . | ..|..||||||
pkekvkl.edgkikvla.....lseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaG

VGRSGTIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
|||.||.. .  ..  . .  .. |. ...||.|..|   .|.  || .......|| 
vgRtGtlialDiavrlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 84-327 9.1e-51 167.6 In-house 38-278 (315) alignment 
Range on Protein: 84-327
Range on HMM: 38-278/315.0
VDAFKSNPEKNRYTDIKCIEKTRVIL--TTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVE
|   . | .|||| .|  ....||.|    |   |||| | |.    . | .|..|||..... ||| ||.|..| .|.|. |  |  ..|| ||||  .
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

GQTNTYvskGhTITINNLgvgTLSPDDDFINvTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYD----TNPVVVHCSAGVGRSGTIVG
...  .   | .| .. |    |..| | ..  .| .  . ..| .| .|.|.|||.|..      ..|| .|  |    . ...|||||||||.| .. 
adsvef...G.sikvell...sleadtdgva.rklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

ISLIMDKMIQgINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
|  ..... .  .  |. ..|...|..| | .||| .| .|. ..||..|
idevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledll
0049772 (Phosphotyrosine protein) phosphatases II 84-331 1.6e-40 135.2 In-house 40-285 (314) alignment 
Range on Protein: 84-331
Range on HMM: 40-285/314.0
VDAFKSNPEKNRYTDIKCIEkTRVIL-TTDGASSDYIHANYVGISikpKKFICTQGPKDSTIYDF----------WAMVI--QDNVESIIM---------
|  .  |..||||.|| . . .|||| . .. .||||.|.||      .|||.||||.. |..||          | ||.  . ||  | |         
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LCKVIELARVKCEQYWPAVEgqtntyvskghtitinnlgvGTLSPDDDFinvtnlelvwagkTRSITHYQWTNWPDHGAPPINM--GA
            |... ..    ......  .                    . | ....|             .| . .| ....||..||....   .
lsrLdaAlgKtpllildgngneptaadlellk....................eelydpelf.............erlgikylripvpDgsaplledfdef

INLIEAVnYDTNPVVVHCSAGVGRSGTIVGISLIMDKMiqgiNCkDMKKLVEEIRNQRH-----YAIQTEAQYMYIHRVLLEYFLELHK
...||..  . .||.|||.||.||.|| | . ..| ..    .. .... .|..|..|.      .|..  || .|...||||.  |.|
lefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 84-327 2.5e-37 123.2 In-house 39-237 (392) alignment 
Range on Protein: 84-327
Range on HMM: 39-237/392.0
VDAFKSNPEKNRYTDIKCIEKTRVIL--TTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELArvkceqywpave
|   . | .|||| .|  ....||.|    | . |||. | |.      | .|..|||. ... ||| || |.|| .|.|. |. |              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

gqtntyvskghtitinnlgvgtlspdddfinvtnlelvWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYD----TNPVVVHCSAGVGRSGTIVG
                                         ..|... ...|.|||.. |      ...|. |. |    | |...||||||||.| .. 
......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvis

ISLIMDKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
|  .. .  .     |. ..| .||..| | .||. || .|.  .|| .|
idsvvaha.kktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_PTPRN_pd Subfamily PTPRN 84-321 3.7e-36 119.3 In-house 50-287 (297) alignment 
Range on Protein: 84-321
Range on HMM: 50-287/297.0
VDAFKSNPEKNRYTDIKCIEKTRVILTTDG--ASSDYIHANYVgISIKPK--KFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPA
|   . | .|||....   ...|| |...    .|||| |  . .   |.   .| ||||  ||. ||| || .. |  |..|... |    .|..||| 
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpd

vEGQtNTYvskgHTITInNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY----DTNPVVVHCSAGVGRSGTI
 ||. ..|    |   . .|    .  || ..    |  . . .||..| . .  ||..|.|.     ...   ||      . |.|||||.|.||.|. 
.eGs.evy....hiyev.hlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvy

VGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRV
. | |.......|..  |.   .| .|.||.  ..|..|. ..  .
ilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_egg_pd Subfamily egg 85-355 7e-41 134.9 In-house 35-292 (307) alignment 
Range on Protein: 85-355
Range on HMM: 35-292/307.0
DAFKSNPEKNRYTDIKCIEKTRVILTT-DG-ASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELarVKCEQYWPAVEG
 | . | || |   ..| . .|| |    |  . |.||||.|       .||..| |   |  ||| || |..|. |.||    |    .|| |||  | 
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

QTNTYVSKGhtITINNLGVGtlSPDDDFINVTNLELVWAGK-TRSITHYQWtNWPDHGAppInMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLI
..  .|  .  . |.||.|   |  | . .||.| || . .  | . |.|. ..   .   .    ....  .   ..||||..  || ...|.| | . 
dslvtvpGs..lrienlkvd..skadplfrvtklklvGgddeerflehwqg.dvnnssd..v.ysplrvlrklrnlskpvvvqdilGvskaatlvaieia

MDKMIQGINCK-DMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKEtyeglllTKNYEEKYAKWLDDYN
. ....|   |  ... |  .| .|......  .|....|..| .| ..          .|. .  | .||... 
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs.......akeldvdyerwleers
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 85-348 1.9e-36 120.7 In-house 14-284 (290) alignment 
Range on Protein: 85-348
Range on HMM: 14-284/290.0
DAFKSNPEKNRYtDIKCIEKTRVILTTDGA--SSDYIHANYVGISiKPKKFICTQGP-------KDSTIYDFWAMVIQDNVESIIMLCKVIELARV----
|  |..  ..|. ..  .|.|||.|   |   ..||||||.| .. .  ..| || |       ..||| .|| |. |..|....|||.. |  .     
dyvkkhemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslf

KCEQYWPAVEGQTNTYvsKGHTITInnlgvGTLSPDDDfINVTNLELVWAGK-TRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDTNPVVVHCSAGVG
 |..| |  .|.  ..  || |.            .|| ... .|.. . ..    .||..  .| .  ... .  ...||. |.  . ||.|||  |. 
aCakYvpesvgeelkf..kgltvkC.....kskekedd.vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiS

RSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTK---NYEEKYA
|| ..  | | . |...  .   ........|.||  ||... .. ..  ... .. |  ....|    .|   ...| | 
rsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeeketyk
0042113 (Phosphotyrosine protein) phosphatases II 86-326 2e-70 232.3 In-house 5-243 (245) alignment 
Range on Protein: 86-326
Range on HMM: 5-243/245.0
AFKSNPEKNRYTDIKCIEKTRVILTTDGAS--SDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAveGQ
... |..||||.|| . . |||.|. || .  ||||.|.||. .  ..|||.|||| ..|. ||| |. . ....|.||..  || ||||.||||   |.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

TNTYvskgHTITINNLGVGTlspdDDFINVTNLELV--WAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNY-----DTNPVVVHCSAGVGRSGTIV
. ||    ...|...|.. .    .| . |..||..    ...| ..||....|||||.|..    ....|.|.      . .||.|||||||||.||..
slty....gdftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

GISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.. |... .     . .. . |.|.|.||. |.||. ||......|||..
aaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 86-328 3.8e-43 142.9 In-house 44-290 (325) alignment 
Range on Protein: 86-328
Range on HMM: 44-290/325.0
AFKSNPEKNRYTDIKCIEKTRVILTT--DGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNvESIIMLCKVIELARVKCEQYWPAVEGQ
.   | .|||. ..  ..|.||.| |  | .||||| |.|.   .| . |. .| |. .|| |.| .|.. .  |....  ...|   .| .|||   |.
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgk

TNTYvskGhTITINNLGVGTLspDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAIN---LIEAVN----Y---DTNPVVVHCSAGVGRSG
. |.   | .. ..   . ..   |    | ..  |  |.|||.  .|.  |.| | .      |.   |..||.         . |..|||||||||.|
sktf...G.glevklrtieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

TIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
. . .  ...|.|.  .  |. . |. .|..|   ..|  ||. |.  | |... 
vfislysalakvieesrv.difgfvkklrkdrpsmvetvdqyiliyealveayms
0037934 (Phosphotyrosine protein) phosphatases II 87-326 3.9e-65 215.1 In-house 7-242 (243) alignment 
Range on Protein: 87-326
Range on HMM: 7-242/243.0
FKSNPEKNRYTDIKCIEKTRVILttDGasSDYIHANYVGISikpKKFICTQGPKDSTIYD----FWAMVIQDNVESIIMLCKVIELARVKCEQYWPaveg
.. | .||||.|| . . .||.|  .|  ||||.||.. .    ...|.|||| ..|. |    || |. . ....|.||.. .|| |.||.||||    
lpenlsknrysdilpydhsrvkl..eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

qtNTYvsKGHTITINNLGVGTLSPdddfINVTNLELVW---AGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN------------YDTNPVVVHCSA
  ...    ...|...|.. .|.     . |..|.|..    . || ..||....|||||.|.     ......|.             . .||.|||||
..gev..tygdftvtllseehldd....ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRSGTIVGISLIMDKMiqginCKDMKKLVEEIRNQRHY-AIQTEAQYMYIHRVLLEYF
||||.||.. . |.....     . |. . |...|.||.. |.||. ||......|||..
GvgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 87-328 1e-60 200.1 In-house 37-279 (290) alignment 
Range on Protein: 87-328
Range on HMM: 37-279/290.0
FKSNPEKNRYTDIKCIEKTRVILTTDGA--SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQT
 ..| .|||| ||   .|.|| |...     |||| ||..  . .....| .|||   |. ||| |... ||| ..|.|...||.. |||.|||   ...
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

NTYvskgHTITINNLGVGTLspDDDFInVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN----YDTNPVVVHCSAGVGRSGTIVGISL
 ..     ......    ..  ||||. .  |..   ...|... ...|.||||| |      ..|||.|.     . .|.|||||||||| |||. | .
lef....gefevtleeekav..dddfl.irtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

IMDKMIQGIN--CKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
. . . ...   . |. .|| |.|.||. ..||. || .... ..|.. .
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 87-332 5.7e-46 152.3 In-house 22-261 (284) alignment 
Range on Protein: 87-332
Range on HMM: 22-261/284.0
FKSNPEKNRYTDIKCIEKTRVILT-TDGA-SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCkvielaRVKCEQYWPAVEGQT
 . | .|||...|   .|..| |  ..|   |||| | ..    ...|.| ||||.| |. ||| |. . |. .|..|       . || ||||    ..
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

NtyvSKgHTITINnlgvgTLSPDDDfINVTNLELVWAGK---TRSITHYQWTNWPDHGAPPINMGAINLIEAVNY------DTNPVVVHCSAGVGRSGTI
.    .   . ..     ...  ..   | ..||   ||    |.|. . .  |||.| |  ..  . |.. |..      . ...||||||||||.|. 
e...er.fkvkvd.....sveesee.yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

VGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKE
. .  ..|.| .  .  |. ..|...|.||   .|  .||..|.  ||| .|  | .
ivldvlldrmkee.kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_CG7180_pd Subfamily CG7180 87-328 4.3e-39 128.9 In-house 39-292 (296) alignment 
Range on Protein: 87-328
Range on HMM: 39-292/296.0
FKSNPEKNRYTDIKCIEKTRVILTT-DGA-SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARvKCEQYWPAV--EG
 | | ||||. ..   ...||.|.. ||  .|||| | ||   .|.|..| |..||..|. .|| .| .........|.|. . |. .. .|||    | 
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

QTNTYVSKGHTITINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPD-HGAPPINMGAINLIEAVN---------YDTNPVVVHCSAGVGRS
  .  |   .. .  ||   |.      . .|. |     .|| ....|.| |.  .  | .  . |.|.. |.          ...||||..| |..||
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
|  ..|   ......  .. |. . |  .|..|   ...  .|.||  ||||..| 
Gvylaidanlelveke.eevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_PTPN6_pd Subfamily PTPN6 88-327 2.7e-53 176.0 In-house 52-298 (306) alignment 
Range on Protein: 88-327
Range on HMM: 52-298/306.0
KSNPEKNRYTDIKCIEKTRVILTTDGA-SSDYIHANYVG--ISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQT
..| |||||  |   ..|||||. ..   |||| |||.   .  . |..| |||  ..|. ||| || |.| . |.|. | .| .. || .|||..| ..
penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

NtYvskGhTITINNLGVgTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYD--------TNPVVVHCSAGVGRSGTIV
. |   | .|...|.   .   | .. ...  .   ....|.. .|....||||| |      ....| ||          . |.|||||||.|| ||..
e.y...G.kisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

GISLIMDKM-IQGINCK-DMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
 | ......  .|.... |..|||. .|.||   .|||.|| ...... .|  
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_PTPRK_pd Subfamily PTPRK 88-325 1.9e-52 173.0 In-house 41-276 (314) alignment 
Range on Protein: 88-325
Range on HMM: 41-276/314.0
KSNPEKNRYTDIKCIEKTRVILT-TDGA-SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAvegQTN
. | ||||..||   ...||.|. .||  ||||| |...    .|..|| ||||...|..||| .| ..|  ||.|| ...| .|||| .|||    .|.
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe...dte

TYvskgHTITINNLGVgtlSPDDDFIN-VTNLEL--VWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDT----NPVVVHCSAGVGRSGTIVGI
.|      | .. . .   ... .... . ..|       ..| . ..|...||||. |  . | ..|.  |.  .     ..||||||| ||.|| . |
vy....gdikvelvet...ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiai

SLIMDkMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
. ..| ||.  .  |. . | ..|...   ..|| ||..|. |.|| 
divld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 88-328 1.2e-42 141.1 In-house 49-286 (297) alignment 
Range on Protein: 88-328
Range on HMM: 49-286/297.0
KSNPEKNRYTDIKCIEKTRVILTTDGAS--SDYIHANYVGISIKpkKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARvKCEQYWPAVEGQTn
| | ||.||..|  ... ||.|   . .  |||. | .|    .  ..|.|| |...|. ||||||....|  |.|| .  |  . || .||.    .| 
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.

tyvsKGhTITINNLGVGTLspdDDFINVtNLELVWA--GKTRSITHYQWTNWPDHGAPP--INMGAINLIEAVNYD--T---NPVVVHCSAGVGRSGTIV
     | ....  | |        ||.  .||.      ..| .  ||...|||.  .        ..||. |. |  .   .|..|||.||||| | ..
....fG.dvsvvllsvser...eGfikr.elevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

GISLIMDKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
 |  .. .. .  .  |. .||. .|..| | .||. || ... ..||..| 
tidsvvaea.krekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 89-326 7.2e-50 164.5 In-house 8-242 (250) alignment 
Range on Protein: 89-326
Range on HMM: 8-242/250.0
SNPEKNRYTDIKCIEKTRVILTTDG--ASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVkCEQYWPAvEgQTNT
.| |||||.||  ....||.| ..     |||| | ..    . | || ||||  .|| ||| ||.......|.|| .. |  .. ..||||. | ....
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.e.kaek

YvskGHtITINNLGVGTLSpddDFInVTNLELVWAGKTRS--ITHYQWTNWPDHGAPPINMGAINLIEAVN----Y-DTNPVVVHCSAGVGRSGTIVGIS
|   |. .|.. |   . .   |.. ...| |  | |. .  . ......||| | |     ...|.. |.    . ...||.|.|||||||||. . |.
y...Gd.vtvsllskeefa...dyt.krklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

LIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 ..... .  .  |. |... .|..|  |.....||.......|.. 
avlerlkke.kvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 89-329 1e-44 147.7 In-house 48-282 (315) alignment 
Range on Protein: 89-329
Range on HMM: 48-282/315.0
SNPEKNRYTDIKCIEKTRVIL--TTDGASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVegqTNT
 | .|||| .|   .|.|| |  .     |||. ||..    |....|..|||. ... ||| .| ....  |.|| ...|  . |.|.|||       .
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kvi

YvsKGHTITINNLGVgtlspdDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN-YDTN---PVVVHCSAGVGRSGTIVGISLIM
|     |.|  .  |       . . |  |  |   . | .  ...| ||| | |   .  .|||  |. ..||   ..||||||||||.|| . .. ..
y..Gkitvtrkseev......nteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

DKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLEL
|.. .  |  |. .... .|..|  ..|. .|| .|. .||| |.  
dqa.eaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 89-324 3.2e-34 113.1 In-house 6-238 (239) alignment 
Range on Protein: 89-324
Range on HMM: 6-238/239.0
SNPEKNRYTDIKCIEKTRVILT--TDGASSDYIHANYVG-ISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAvegQTN
 |  ||||..|   ...||.|   ..   |||| |.|.      || .|.|||    .  ||| |. |.    |.||  .||  . || ||||     |.
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...sts

TYVSKghTITINNLGVGTlspdDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDT----NPVVVHCSAGVGRSGTIVGISLI
 |.     .|. .  | .    |  |    .  |   . | . .|..| |||.| |      . |   .  |.     | |.||||||||.|... |  .
kycnl..rvtlrktevfa....dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

MdKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
. .  .  .  |. . |. ||..| . .||  ||..||  .||
l.rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 89-324 3.8e-34 112.9 In-house 7-239 (239) alignment 
Range on Protein: 89-324
Range on HMM: 7-239/239.0
SNPEKNRYTDIKCIEKTRVILT--TDGASSDYIHANYVG-ISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAvegQTN
 |  ||||..|   ...||.|   ..   |||| |.|.      || .|.|||    .  ||| |. |.    |.||  .||  . || ||||     |.
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd...sts

TYVSKghTITINNLGVGTlspdDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDT----NPVVVHCSAGVGRSGTIVGISLI
 |.     .|. .  | .    |  |    .  |   . | . .|..| |||.| |      . |   .  |.     | |.||||||||.|... |  .
kycnl..rvtlrktevfa....dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

MdKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
. .  .  .  |. . |. ||..| . .||  ||..||  .||
l.rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
Y_phosphatase Protein-tyrosine phosphatase 90-324 3.7e-73 241.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 90-324
Range on HMM: 1-235/235.0
NPEKNRYTDIKCIEKTRVILTTDGASSDYIHANYV-GISiKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYv
| .||||.|| ...|||| |. .. .||||.|||| | . ..||||.|||| .||| |||.||.| .|..|.||... |  |.||.||||  |....|| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty.

skgHTITINNLgvGTLSPDDDFINVTNLELVWAGK---TRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDT----NPVVVHCSAGVGRSGTIVGISLI
   ..|....      . |.. .....|||   ..   .|.......|||||||.|  . . ..||..|. ..    .||||||||||||.||.| ....
...gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

MDKMIQGINcKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
.... .. .  |....|.|.|.||. ..|...||.......||
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 90-324 3.7e-73 241.2 In-house 1-235 (235) alignment 
Range on Protein: 90-324
Range on HMM: 1-235/235.0
NPEKNRYTDIKCIEKTRVILTTDGASSDYIHANYV-GISiKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYv
| .||||.|| ...|||| |. .. .||||.|||| | . ..||||.|||| .||| |||.||.| .|..|.||... |  |.||.||||  |....|| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty.

skgHTITINNLgvGTLSPDDDFINVTNLELVWAGK---TRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDT----NPVVVHCSAGVGRSGTIVGISLI
   ..|....      . |.. .....|||   ..   .|.......|||||||.|  . . ..||..|. ..    .||||||||||||.||.| ....
...gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

MDKMIQGINcKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
.... .. .  |....|.|.|.||. ..|...||.......||
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 90-328 1.5e-51 169.8 In-house 1-173 (182) alignment 
Range on Protein: 90-328
Range on HMM: 1-173/182.0
NPEKNRYTDIKCIEKTRvilttdgaSSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCkvielarvkCEQYWPavegqtntyvs
| .||||.|| ... .|         .|||.||..  | ....||.|||| .||..||. |. . .. .|..|.         .|.|||           
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

kghtitinnlgvgtlspdD-DfinvtnlelvwagkTRSITHYQWTNWPDHGAPPiNMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKmiqg
                  .                .| ...|....|||||.|.    ....||.|. . .||.|||||||||.||.|.. |.. .    
..................ell..............erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl....

inCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLE
    .. . |...|..|. ...|. || .....|||..| 
..gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 90-324 2.1e-43 143.2 In-house 3-237 (237) alignment 
Range on Protein: 90-324
Range on HMM: 3-237/237.0
NPEKNRYTDIKCIEKTRVILTTDGASSDYIHANYV-GISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEgQTNTYV
|  |||| .|.. ...||.|   |..|||| |.|. |.   |||.|..||| .|.  ||| || |..   |.||  .||  ..|| .|||  . | ..| 
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaayg

SkgHTITINNLGVGTLSPDDDFINVTNLELVwagKTRSITHYQWTNWPDHGAPPINMGAI----NLIEAVNY--DTNPVVVHCSAGVGRSGTIVGISLIM
    |...      .      .. ...|.|    . | |  ||.| |||.| |      .    |.|.  ..  .. | ..||||||||.| .. |  ..
v..ltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

dKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
 .  .  .  |. . |  | ..| | |||. ||..||...||
.rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 90-326 3.5e-43 142.4 In-house 38-277 (287) alignment 
Range on Protein: 90-326
Range on HMM: 38-277/287.0
NPEKNRYTDIKCIEKTRVILTTDGA-SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVegQTNTYV
. .||||.|.  |..|||.|...|   |||| ||||    . ..||..|||  .|. ||| .|.. .. |.|.. . .| || || .|||    .    |
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer..evPmrv

SkGHTITInnLGVGTLSPDddfINVTNLELVWAG--KTRSITHYQWTNWPDHGAPPINMGAINLIEAV---------NYDTNPVVVHCSAGVGRSGTIVG
  |.....  |    ..|.     |  | |. .   ..| .  ... .|||....|  .| | ..  |           .. |.|||...|.||||... 
G.Gysvvl..ldydikePe...ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

ISLIMDkMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.  ... . . .   |. . |  .|..|   .|.  |. ..   |  |.
tlvlvs.rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 90-241 3.4e-35 116.3 In-house 33-180 (297) alignment 
Range on Protein: 90-241
Range on HMM: 33-180/297.0
NPEKNRYTDIKCIEKTRVILTTDGASSDYIHANYVGISIK--PKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTy
   ||||.||   ..||| |    . .||| |.||    .  . |.|..||| ..|. ||| .| ...|  |.|..|. |  | ||  ||| |...  . 
slrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlk.

vskGHTITINNlgVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAP
      . ..   . . | . | . .|.|.|..  ..| ..| |. .||||| |
...agdvvvef..lsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvp
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 92-318 4.2e-44 145.5 In-house 52-273 (301) alignment 
Range on Protein: 92-318
Range on HMM: 52-273/301.0
EKNRYTDIKCIEKTRVILTTDGASSdYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTnTYVsKG
.|.||  . |  .| | . .||     ||||..  | .|..||.|||| ..| .|||||..| .|| |.||.. .|    |||.| |   ...   . . 
dkhryptvPckPstavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek.ldi.gr

HTITINNLGVgTLspdDDFINVTNLELVWAG---KTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQG
..|.|.|  .  |   .. |.  .||.. .    .||..||||...|.|.| |   .   .|.| |    .|.|||||||.||| . .|   .  ..   
fkikiknkel.il...nkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevead

iNCKDMKKLVEEIRNQRHYAIQTEAQYMYI
 .  .... ....|..|  ..||. |  ..
.ptieltealkhlrehrwngvqtnsqlywm
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 92-326 1.1e-27 91.7 In-house 49-344 (350) alignment 
Range on Protein: 92-326
Range on HMM: 49-344/350.0
EKNRYTDIKCIEKTRVILT-----T-----DGASSDYIHANYVGIS-----IKPK-KFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQ
 ||||..|   |..||.|      .        ..||| |||. ..     |.|. |.| ||.|  ||. ||. ......|. |..| . .|| . ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPAVEGQT------NTYVSKG--HTITINNLGVGTLSPDDDFIN----VT----NLELVW-AGKTRSITHYQWTNWPDHG---APPINMGAIN----LI
||.  . .       ... . .  . ...   .| . ..|.| |.    .     . ..   |     . . |. ||.| .    |   . |..    ||
YWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndli

EAV-------NYDTNPVVVHCSAGVGRSGTIVGISLIMD-----KMIQGIN--------CKD-MKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
.         |  ..|..||||||||| ||.| .  ..      ....            .| .. .| |.|.||   .|.  |...|.  || ||
ddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_eak_pd Subfamily eak 103-241 1.3e-09 31.9 In-house 64-195 (332) alignment 
Range on Protein: 103-241
Range on HMM: 64-195/332.0
EKTRVILTTD-GASSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYvskGH-TITINNLg
..  | ||.       || |  .  |   .|.| |  .... .. || ||.. .  .|..| . .||   | ..|.|    .   .   |.  ..  .  
drylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf...Gildverkef.

VgtlspDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAP
|       . ... .|||    .|  . ||.   | .   |
v.....krniletrllelskGnethrvlhykvfGwtettlp
0046846 (Phosphotyrosine protein) phosphatases II 106-326 3.4e-44 146.0 In-house 2-173 (176) alignment 
Range on Protein: 106-326
Range on HMM: 2-173/176.0
RVILTTDGASSDYIHANYVGISikpkKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNtyvskghtitinnlgvgtls
|. |.... ..|||.||..  |    ..|.||||  .|..||..|. . ... ...|.. .||.|.|| .||| .|.                       
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

pdddfinvtnlelvwagktrsitHYQWTNWPDHGAPPIN--MGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKmiqgiNCKDMKKLVEEIRN
                       .|....|||||.|...  . ....|. .  . .||.||||||.||.||.| . |.. .     .. .. . ....|.
.......................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllele.....kglsveealalvre

QRH-YAIQTEAQYMYIHRVLLEYF
||. .|.||..|| ......|...
qRplgavqtpeQyrflyefellll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 110-180 3.9e-13 43.5 In-house 84-156 (349) alignment 
Range on Protein: 110-180
Range on HMM: 84-156/349.0
TTDGASSDYIHANYVGIS-IKP-KKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAV
.  |   ||| |||. .. |.. ||.|.|| |  ||. ||. ... ..|. .. | .  ||.  ||..||   
sdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
0044763 (Phosphotyrosine protein) phosphatases II 114-326 3e-34 113.6 In-house 16-171 (178) alignment 
Range on Protein: 114-326
Range on HMM: 16-171/178.0
ASSDYIHANYVGisikPKKFICTQGPkdstiYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGqtntyvskghtitinnlgvgtlspdddfinv
 .||||.|...     |  ......|      |..... . .. .|..|.. .|| ..|| .|||  .|                               
ersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

tnlelvwagktrsiTHYQWTNWPDHGAPPINMGAINLIEAVN----YDTNPVVVHCSAGVGRSGTIVGISLIMDKmiqginCKDMKKLVEEIRNQRHyAI
               .|.....||||.|..     ...|...     . .||.||||||||||||.| . |..          .. . .|..|..|  ..
..............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.iv

QTEAQYMYIHRVLLEYF
... |. ..... |...
pnpgqlrqLyefelrll
0043147 (Phosphotyrosine protein) phosphatases II 115-319 2.1e-44 146.6 In-house 4-154 (172) alignment 
Range on Protein: 115-319
Range on HMM: 4-154/172.0
SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVielarvkceqywpavegqtntyvskghtitinnlgvgtlspdddfinvt
.||||.|.|. ....|..||.|||| ..|. |||.|. . ..  |..|..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

nlELVWAGKTRSITHYQWTNWPDHGAPpINMGAINLIEAVNY-----DTNPVVVHCSAGVGRSGTIVGISLIMdkmiQGInckDMKKLVEEIRNQRHYAI
  .. . . .|.. .|....|||||.| .    ....| ..      . .||.|||||||||.||.| . |..    .|.   .. . |...|..| .|.
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl...sleeavalvrekRpgav

QTEAQYMYIH
|.. ||....
qnpsqyrfly
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 115-242 7.8e-10 33.2 In-house 12-128 (130) alignment 
Range on Protein: 115-242
Range on HMM: 12-128/130.0
SSDYIHANYVGISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIElarvkCEQYWPAVEGQtNTYvSkgHTITINNlgvgTLSPDDDFINVT
  .||.|..||.. . .... || |   |  ||| |...  |. ...|  | |      ..|||  |   . |    . |..      |   . ..|. .
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpdsePl.ewy.e..ediivtl....tdrdefknikas

NLELVWAGKT--RSITHYQWTNWPDHGAPP
|||     .   ...| .| .|||  |. |
nleiesdlneshqaltmfqisnwpsdgttp
0051429 (Phosphotyrosine protein) phosphatases II 116-337 2.1e-46 154.1 In-house 4-236 (272) alignment 
Range on Protein: 116-337
Range on HMM: 4-236/272.0
SDYIHANYVGI---SIKPKKFICTQGPKDSTIYDFWAMvIQDNVESIIMLCKVIELARVKCEQYWpavegqtntyvSKGHTITINNLGVGTLSPDDDFIN
|.||.|..||     .||.......|| . |. |||..  . .. .|..|... |..|.||..||              . . .. |. .. ..   .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw...........pgirylhlpilddsaptilygalr

VTNLELV----------------WAGKTRSITHYQWTNWPDHGAPP-INMGAINLIEAvnydTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKD--
||.|. .                 ||..| ..|...|.|||||.|.     ...|. .     .||.||||||..|.||.| . |..  .     ..|  
vtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYl

-----MKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGL
     . . |||.| ||..|.|||.||......|||.. .|    .| |
ltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyl
0036282 (Phosphotyrosine protein) phosphatases II 116-320 3.7e-45 149.1 In-house 2-164 (174) alignment 
Range on Protein: 116-320
Range on HMM: 2-164/174.0
SDYIHANYVGISIKPKKFICTQGPKDstiydFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAvegqtntyvskghtitinnlgvgtlspdddfinvtn
||||.|.....|. ....|..||| .     ||.|. . ......||.. .|| ..|| .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

lelVWAGKTRSITHYQWTNWPDHGAPPINMgAINLIEAVNYD-----TNPVVVHCSAGVGRSGTIVGISLIMDKMIqgINCKDMKKLVEEIRNQRHYAIQ
    .   .|.. .|....|||||.|....  ......|.        .||.|||||||||.||.|.. |..  ..   .  |  .|| |.|.||....|
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvq

TEAQYMYIHR
|. ||.... 
tpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 116-323 5.5e-33 109.1 In-house 3-150 (151) alignment 
Range on Protein: 116-323
Range on HMM: 3-150/151.0
SDYIHANYVGisikPKkFICTQGPKDstiyDFWAMVIQDNVESIIMLCKVIELArvKCEQYWPAVEgqtntyvskghtitinnlgvgtlspdddfinvtn
||||...||.    .  .....|| .    ||.... . .. .|..|..  | .  .| .|.|. .                                  
sdyinfsyvt....gg.lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

lelvwagktRSITHYQWTNWPDHGAPPINMGAINLIEAVNYD-TNPVVVHCSAGVGRSGTIVGISLIMDKmiqgincKDMKKLVEEIRNQRHYAIQTEAQ
         . ..|.....|||.| | .   .....|... .  .||.||||||.||.||.|.. |.. .        .. . .||.| .|....|.. |
.........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqq

YMYIHRVLL
.......||
flfqlfall
0049260 (Phosphotyrosine protein) phosphatases II 126-319 1.6e-40 133.6 In-house 4-143 (152) alignment 
Range on Protein: 126-319
Range on HMM: 4-143/152.0
ISIKPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWpavegqtntyvskghtitinnlgvgtlspdddfinvtnlelvwagktr
.  .|..||.|||| . |. ||| |. . ..  |.||..  ||...|||||.                                                
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................

sitHYQWTNWPDHGAPPINMGAINLIEAV----NYDTNPVVVHCSAGVGRSGTIVGISLIMdkmiqgiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIH
   .|....|||||.|.. .  . |....     .. .||.|||||||||.||.| . |..       .  .... |. .|..| .|.... |.....
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 129-180 1.2e-08 28.7 In-house 234-282 (440) alignment 
Range on Protein: 129-180
Range on HMM: 234-282/440.0
KPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKvieLARVKCEQYWPAV
| . ||.|| | |||. ||| .| . .. .|||| .   |    |  |||  
kknafiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvn
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 131-319 7e-15 49.7 In-house 4-196 (198) alignment 
Range on Protein: 131-319
Range on HMM: 4-196/198.0
KKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHTitINNLgvgTLSPDDDFINVTNL-ELVWAGKTRSITH
...|.|| |   |. ||| || .     |.|.        .    |||..|  |  | |   |   . .   |  ||     .    .      || |.|
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt..tkti...ttkpdytitaliltnnttappstreish

YQWTNWPDHGAPPINM--GAINLIEAV--NYD---TNPVVVHCSAGVGRSGTIVGISLIMDKM-IQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIH
||.| | .. .| . .  | .     |  .|.     ||.|||| | | .| .| . . .           |. ..   .|. |   | .  .| .|.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 131-319 7.1e-15 49.7 In-house 5-197 (199) alignment 
Range on Protein: 131-319
Range on HMM: 5-197/199.0
KKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYVSKGHTitINNLgvgTLSPDDDFINVTNL-ELVWAGKTRSITH
...|.|| |   |. ||| || .     |.|.        .    |||..|  |  | |   |   . .   |  ||     .    .      || |.|
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt..tkti...ttkpdytitaliltnnttappstreish

YQWTNWPDHGAPPINM--GAINLIEAV--NYD---TNPVVVHCSAGVGRSGTIVGISLIMDKM-IQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIH
||.| | .. .| . .  | .     |  .|.     ||.|||| | | .| .| . . .           |. ..   .|. |   | .  .| .|.
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 137-320 1.1e-26 88.0 In-house 97-282 (302) alignment 
Range on Protein: 137-320
Range on HMM: 97-282/302.0
QGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPA-VEGQTNTYVSKGHTITIN-NLGVGTLSPDDdfiNVTNLELVW---A-GKTRSITHY
  || ||.  .||.. | ||  .. ||...|    || .|.   |.|. .      .|. .. .|   |   .    .. ..|.        . ...   
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksf...klytveiknekkkkkvkktvdil

QWTNWPDHGAPPINMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMiQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHR
... |||||||     |....   .   . |.|||||||||.||.| |   ..   .  .  |. ..|  .|. |. |.|.| | .|.  
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlc.skkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 139-326 6.8e-07 22.2 In-house 126-309 (346) alignment 
Range on Protein: 139-326
Range on HMM: 126-309/346.0
PKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYwpavEGQTNTYVSKGHtITINNLGVgTLSPDDDFInvtNLELVWAGKTRSIT--HYQWTNWP
 ..| . ||| |. |.... . ..     |       .    . .   |   |. . |||     .| |        .|..  |.. |.    .. . | 
enesfvedfwymiyqeqihlvylmvpddklkntttslf....ndenggyqytgk.mfinnrra.dvsgdpkey...tievlpegnsdsvicqvhhhapwk

DHGAPPINMGAINLIEAVNY----DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCkDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
    ||  .  |..|          .  | |    | ||. ...|    .... .||.  .. ... .|..||  .... |||  |. ....| 
hlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiep.niceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 140-327 5.8e-29 95.9 In-house 36-222 (255) alignment 
Range on Protein: 140-327
Range on HMM: 36-222/255.0
KDS-TIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYvsKGHTITINNlgvgtlSPDDDFINVTNLELVWA--GKTRSITHYQWTNWP
 .| |.  |. ...| . | ..|||   | ...||..|.|    .   .  .  ..|  .      |  |  .   .. .  .   ||. ..||... |.
lysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkl..advnvtttk......ssadvvlrtleitstlgekkkthtvkhysykGWi

DHGAPPINMGAINLIEAVNyDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCK-----DMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFL
.. ||       |.. .|  |. .||||||.|.||| . | . |.  |||. ..       | ..|.||.|..|. ||.|  |  .   ..|... 
eknaPelareilnilkvvr.dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvf
subfamily_hpo-7_pd Subfamily hpo-7 143-329 4.4e-25 83.1 In-house 46-230 (263) alignment 
Range on Protein: 143-329
Range on HMM: 46-230/263.0
TIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQTNTYvsKGHTITINNLGVGTLSPDDDFINVtnLELvwAGKTRSITHYQWTNWPDHGAPP
||  |. .. | . | ..|||   | ...||..|.|    .   .  .  ...  .    .|    .....  |.     ||. ..||... |... .| 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl..anvnvcttkvqsdvllktlellst..lge..KkkthtvkhysykgWiekndpe

INMGAINLIEaVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCK-----DMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLEL
     .|... |. .  ..|||||.|.|||   . . |.  |||. ..       |  .|.||.|..|. ||.|  |  .   ..|...|. 
lareilnilk.varnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 205-327 1.9e-16 54.4 In-house 72-195 (440) alignment 
Range on Protein: 205-327
Range on HMM: 72-195/440.0
SPDDDFINVTNLELVwagKTRSITHYQWTNWPDHGAPPINMGAINLIEAVNYD-----TNPVVVHCSAGVGRSGTIVGISLIMDKMIQgINCKDMKKLVE
 ||.|.|| . .. .   ..|.. .|..  |||.| | .    ...|. ||         |..||||||.||.| |. .  |. .  .  .  |.  ...
vpdsdyinasyingi...esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakr.sdqidifsfin

EIRNQRHYAIQTEAQYMYIHRVLLEYFL
 .||.|   .||  || ..| ..|| .|
smrnnrpqmvqtpeqyafvheavlegll
0048179 (Phosphotyrosine protein) phosphatases II 211-320 2.2e-23 78.0 In-house 34-139 (144) alignment 
Range on Protein: 211-320
Range on HMM: 34-139/144.0
INVTNlELVWAGKTRSITHYQWTNWPDHGAPPINMGAINLIEAVN---YDTNPVVVHCSAGVGRSGTIVGISLIMdkmiqgINCKDMKKLVEEIRNQRHY
||.|. |  ..  .| ...|....|||||.|..    ....|...    . .||.|||||||||.||.| . |..       .  .... ....|..| .
inlte.eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpg

AIQTEAQYMYIHR
|.... |......
avpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 212-325 7.5e-25 82.7 In-house 32-142 (145) alignment 
Range on Protein: 212-325
Range on HMM: 32-142/145.0
NVTNLELVWAGKTRSITHYQWTNWPDHGAPPINMG---AINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDkmiqgiNCKDMKKLVEEIRNQRHYA
 | ||     . .| ...|....|||||.|..      ....||..  . .||.|||||||||.||.|.. |..       .  .. . .|..|.||..|
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpga

IQTEAQYMYIHRVLLEY
.... |. ......||.
vpnpgqlrflyefelel
subfamily_MTMR3_pd Subfamily MTMR3 222-287 1.3e-06 20.4 In-house 234-299 (442) alignment 
Range on Protein: 222-287
Range on HMM: 234-299/442.0
GKTRSITHYQWTNWPDHGAPPInMGAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGIS-LIMDKMIQ
 ... ... . |.|  . .  .   |....|||. .. ||.|||| |  |   || .. |..|.  .
desnwlsalektkWlqnlsvll.kaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyr
subfamily_PTPDC1_pd Subfamily PTPDC1 225-319 1.4e-09 32.6 In-house 81-169 (182) alignment 
Range on Protein: 225-319
Range on HMM: 81-169/182.0
RSITHYQWtNWPDHGAPPINM-GAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGinckdmKKLVEEIRNQRHYAIQTEAQYMYIH
. |..|..  |.|.|.....    |  . |   . . | ||| || || | ..   |.  | ...      .| .. .|..|  .|||  |   ..
qgiyvynf.gwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrlta......ekaiklvrskrpksiqtreqvelvk
PTPc_DSPc_SM00012 227-324 1.4e-31 104.2 In-house 2-105 (105) alignment 
Range on Protein: 227-324
Range on HMM: 2-105/105.0
ITHYQWTNWPDHGAPPINMGAINLIEAVNYDTN------PVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHR
..||..|.|||||.|      ..|..||.  .|      ||||||||||||.||.| ........ .. .. |....|.|.|.||. ..|||.||....|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLLE
.|||
alle
0038934 (Phosphotyrosine protein) phosphatases II 229-320 3.2e-12 42.0 In-house 81-171 (194) alignment 
Range on Protein: 229-320
Range on HMM: 81-171/194.0
HYQWTNWPDHGAPPINMGAINLIEAVNY-----DTNPVVVHCSAGVGRSGTIVGISLIMDkmiQGInckDMKKLVEEIRNQRHYAIQTEAQYMYIHR
.|    .||.|..| .    . ...|.        . |.||| ||.||.||.|.  ||.    .|.   .... .. .|  |  ||..  .. ....
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr...lgm...saeeAialfrekRpgaipnqdyleallk
PTEN_1 229-330 9e-12 40.2 In-house 96-192 (196) alignment 
Range on Protein: 229-330
Range on HMM: 96-192/196.0
HYQWTNWPDHGAPPINMGA---INLIEAVNY--DTNPVVVHCSAGVGRSGTIVGISLIMDKMiqgincKDMKKLVEEIRNQR-HYAIQteaqyMYIHRVL
 |    ..|||||....      ..||..    . | |.||| ||.|||||.|   |.  .        .... .| .| .| . |..     .  .. |
eylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk......ltadeAlelvrekRppgapn.....spsqerl

LEYFLELH
|||| ||.
leyfaell
subfamily_PTEN_pd Subfamily PTEN 235-319 1.3e-08 30.1 In-house 87-173 (184) alignment 
Range on Protein: 235-319
Range on HMM: 87-173/184.0
WPDHGAPPINMGAINLIEAV---NY-DTNPVVVHCSAGVGRSGTIVGISLIMDKMIQgiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIH
  || .||... .  . ..    .  ..| ||||| || ||.|...   |.  ....  . .....| .|.| . . ...  .|  |..
fdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllle..kaeealelfaeaRtknkkgvtiPsqrRYve
0048567 (Phosphotyrosine protein) phosphatases II 235-282 5.8e-06 20.8 In-house 45-101 (157) alignment 
Range on Protein: 235-282
Range on HMM: 45-101/157.0
WPDHGapPIN--------MGAINLIEAVNYDTNPVVVHCSAGV---GRSGTIVGISLIM
. |.|  |.|        . . .... ...  ....|||.||    ||..|..|  ||.
ffdfG..PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil
subfamily_CDKN3_pd Subfamily CDKN3 236-320 1.2e-06 22.3 In-house 108-190 (202) alignment 
Range on Protein: 236-320
Range on HMM: 108-190/202.0
PDHGAPPINmGAINLIEAVNY---DTNPVVVHCSAGVGRSGTIVGISLIMdkMIQGINCKDMKKLVEEIRNQRhyAIQTEAQYMYIHR
.| ..| |    ....| ..    . .  .|||  |.|||  ..   |..  . . |. ||  . . ...  |  ||||  || |.. 
adglvpdia.sclkileelrinlkayrktlvhcygglgrsslviacllly..lddtiepkdaidklrdlkgsr..aiqtvkqynylse
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 245-326 7.2e-09 29.6 In-house 259-338 (347) alignment 
Range on Protein: 245-326
Range on HMM: 259-338/347.0
MGAINLIEAVNyDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
  .  ||  ..   .|||| |  |. || |.|  |.|......| .  |  .|   .|.||   .     | |  |  | |.
esstslianle.klapvvvmcdlgldrsatvvltsiiieqvldg.ktpdcddlfkkmrdqragvftmsifytyairaalfyl
subfamily_PTPMT1_pd Subfamily PTPMT1 246-308 1.1e-08 29.7 In-house 95-154 (171) alignment 
Range on Protein: 246-308
Range on HMM: 95-154/171.0
GAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKmiqGINCKDMKKLVEEIRNQRHYA
 ....|| |  . . | ||| || |||.|.|.  |.. .    .. ..  | ....|.. . |
kgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkke...klspeeAlkalkkkRkiirla
subfamily_DSP15_pd Subfamily DSP15 246-303 4.4e-06 20.8 In-house 66-120 (151) alignment 
Range on Protein: 246-303
Range on HMM: 66-120/151.0
GAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMdkmIQGINCKDMKKLVEEIRN
 ....| .     . |.||| ||| || |.| . |.    .  .| .|. . ... | 
esvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt...vtelnwrdalevikaaRs
subfamily_DSP1_pd Subfamily DSP1 246-287 6.6e-06 20.3 In-house 83-124 (163) alignment 
Range on Protein: 246-287
Range on HMM: 83-124/163.0
GAINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQ
 .|. |..|.     | .|| ||. || |.. . |.. | ..
eviefidevkkknGkvlihCqaGisRsstlclaylmktkrvs
DSPc Dual specificity phosphatase, catalytic domain 247-303 4e-08 28.2 Pfam-A 62-115 (133) alignment 
Range on Protein: 247-303
Range on HMM: 62-115/133.0
AINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLImDKmiQGINCKDMKKLVEEIRN
|.. ||..  . . |.||| ||. ||.|..   |. ..  .... ..  ..|.| |.
avefiekaeqkgkkvlVHCqaGisRSatliiaYlm.kt..knlslneAyefvkerrs
DSPc Dual specificity phosphatase, catalytic domain 247-303 4e-08 28.2 In-house 62-115 (133) alignment 
Range on Protein: 247-303
Range on HMM: 62-115/133.0
AINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLImDKmiQGINCKDMKKLVEEIRN
|.. ||..  . . |.||| ||. ||.|..   |. ..  .... ..  ..|.| |.
avefiekaeqkgkkvlVHCqaGisRSatliiaYlm.kt..knlslneAyefvkerrs
PTPc_motif_SM00404 247-315 6e-08 27.7 In-house 69-130 (140) alignment 
Range on Protein: 247-315
Range on HMM: 69-130/140.0
AINLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLImDKmiQGINCKDMKKLVeeiRNQRhYAIQTEAQY
... ||... .   |.||| ||| ||.|..   |. ..  .... ..  ..|   ...|  .|.  ...
vldfienaekkggkvlVHCqaGvSRSatliiaYlm.ry..rqlslaeayefv...kerR.piispnlnf
subfamily_DSP10_pd Subfamily DSP10 247-303 1.4e-07 25.5 In-house 81-134 (159) alignment 
Range on Protein: 247-303
Range on HMM: 81-134/159.0
AINLIEAVNYDTNPVVVHCSAGVGRSGTIVgISLIMDKMiqGINCKDMKKLVEEIRN
|.. || ..   . |.||| ||. || |.| |. .| ..  ... .|  |.|.| | 
alefieearkkgsrvLvhCqaGisrsatvv.iaYlmkhl..nlslndaykfvkekrp
subfamily_DSP6_pd Subfamily DSP6 247-290 2.6e-06 21.1 In-house 82-124 (158) alignment 
Range on Protein: 247-290
Range on HMM: 82-124/158.0
AINLIEAVNYDTNPVVVHCSAGVGRSGTIVgISLIMDKMIQGIN
||..|.    . . |.||| ||. || |.. .. .| |.   .|
aiefidearskkskvlvhClaGisrsvtvt.laylmkklalsln
subfamily_DSP8_pd Subfamily DSP8 247-331 3.2e-06 20.8 In-house 82-156 (159) alignment 
Range on Protein: 247-331
Range on HMM: 82-156/159.0
AINLIEAVNYDTNPVVVHCSAGVGRSGTIVgISLIMDKMiqGINCKDMKKLVEEIRnqrhYAIQTEAQYMyihRVLLEYFLELHK
... |. ..     |.||. ||  || |.. |. || ..   ..  .  . | | |     .|. . ...     ||||  ||..
svefidkaksengrvlvhvlaGisrsatva.iayimktl..emsldeayrfvkekr....ptispnlnfl...gqLleyekelkl
subfamily_DSP19_pd Subfamily DSP19 248-305 4.9e-07 24.2 In-house 79-130 (152) alignment 
Range on Protein: 248-305
Range on HMM: 79-130/152.0
INLIEAVNYDTNPVVVHCSAGVGRSGTIVgISLIMDKMiqGINCkdmKKLVEEIRNQR
.. || .    . |.|||.||| || ..| |. .| |    ...   .. .|..|..|
ldFieearskdgavlvHCnAGvSRsasvv.iaylmkke..elsl...eealelvrear
subfamily_DSP23_pd Subfamily DSP23 248-318 2e-06 22.5 In-house 74-138 (148) alignment 
Range on Protein: 248-318
Range on HMM: 74-138/148.0
INLIEAVNYDTNPVVVHCSAGVGRSGTIVGISLIMDkmiQGINCKDMkklVEEIRNQRHYAIQTEAQYMYI
....|  .  .. | |||  | ||.||..   |.     ...   .    . |.|..|  ...|  |   .
vrvveeaeekneavsvhcllgrgrtgtmlacylvke...rklaaaea...iaevrrlrpgsvetveqeklv
subfamily_DSP12_pd Subfamily DSP12 250-304 4.3e-06 21.2 In-house 74-125 (155) alignment 
Range on Protein: 250-304
Range on HMM: 74-125/155.0
LIEAVNYDTNPVVVHCSAGVGRSGTIVgISLIMDKmiQGINCKDMKKLVEEIRNQ
 ||    . . |.||| ||| || ||| |  .| |  .......  |||.|....
FieealeeegavlvHCqagvSRSvtiv.iAYlmkk..eklslekAlklvkekkpe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 255-324 1.9e-12 41.7 In-house 225-293 (297) alignment 
Range on Protein: 255-324
Range on HMM: 225-293/297.0
NYDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGiNCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLE
     ...||||||||||| .|    |..|. ..    |.. ... .|.||   .||  |. ... . |.
mprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 256-325 9.9e-16 52.3 In-house 245-314 (319) alignment 
Range on Protein: 256-325
Range on HMM: 245-314/319.0
YDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
 .  |.||||| ||||.|...   . . .. .  .  |. .||  .|..|  |..|  || .|..|| ||
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 256-326 4.7e-08 26.8 In-house 263-344 (349) alignment 
Range on Protein: 256-326
Range on HMM: 263-344/349.0
YDTNPVVVHCSAGVGRSGTIVGISLIMD--KM----IQGINCKDMKK-----LVEEIRNQRHYAIQTEAQYMYIHRVLLEYF
 ......|||||| ||.|..| . |...  ..       |. . ..|      | |.| ||   .|  ||.. |.  ||.||
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
ATP-grasp_2 ATP-grasp domain 257-343 2e-06 14.7 Pfam-A 38-117 (202) alignment 
Range on Protein: 257-343
Range on HMM: 38-117/202.0
DTNPVVVHCSAGVGRSGTIVGISLIMDKmiqgincKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEYFLELHKETYEGLLLTKNY
... .|| .   .|  |   |. |. .|       ...|. ..|. ...  . ||...   ...||.|  .....|.| ...| .. 
gakelvvKaQvlaGGRGKagGvklvksk.......eevkeaakellgkklvtkqtgkegkkvekvlveeavdikrElYlaivlDras
subfamily_PRL_pd Subfamily PRL 259-318 6.8e-07 23.5 In-house 91-142 (151) alignment 
Range on Protein: 259-318
Range on HMM: 91-142/151.0
NPVVVHCSAGVGRSGTIVGISLIMDkmiqGINCKDmkkLVEEIRNQRHYAIQTEaQYMYI
. | ||| ||.||.  .| ..|| .    |.. .|    || ||..|. || .. |  ..
stvavhcvaGlGraPvlvalaliea....Gmkyed...avefirekrrgainsk.qlkfl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 262-325 4.3e-09 30.6 In-house 2-64 (69) alignment 
Range on Protein: 262-325
Range on HMM: 2-64/69.0
VVHCSAGVGRSGTIVGISLIMDKmIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
|||||.| ||.||.. | . | . |.     |.   |  .|  |   .  | .|..||  | | 
vvhcssgtgrtgtfiaimvemar.ikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 262-325 5.3e-09 30.3 In-house 1-63 (69) alignment 
Range on Protein: 262-325
Range on HMM: 1-63/69.0
VVHCSAGVGRSGTIVGISLIMDKmIQGINCKDMKKLVEEIRNQRHYAIQTEAQYMYIHRVLLEY
|||||.| ||.|| . | . | . |.     |.   |. .|  |   .  | .||.||  | | 
vvhcssGtGrtGtfiaimvemar.ikseklvdifnnvqymrkcrpmmvmneneymfihdalvea