Gene F55F8.7 in Caenorhabditis elegans

Synonym: CELE_F55F8.7, F55F8.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf15
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP099_AA protein Get Run
CeleP099_AA_173-440 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 168-440 2.5e-51 169.5 In-house 6-278 (307) alignment 
Range on Protein: 168-440
Range on HMM: 6-278/307.0
WAFKAAKMKCQAISKLHQdKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNH--DRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIY
|  .. ..  ||.    . ..  . |   |  |..||.| ||| ||.|.. .|.|.| .    ||||| .. .  |    .| .|||| .|  .|| |. 
wvqrtldkgvqalvdefr.vlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp.kkficaqgplentqysfwamai

QEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTE--CKEEAIA--GTILNSlTVINTeDATSEPLYMNHVQVPWWPDQLAPEDARPMIEL
|||.  |.||| . | .  ||  |.| . |.   ||.   |..      . .|    ..|  | ..  | ...   ..|.|   |||. .|.     |.|
qekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkv.dwaqksrtiqhlqwenwpdrgvpqinltainl

ykwVKKVNPKEKPICVHCSAGVGRTATFVGIDYATIRIMENPNI-EMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
   .. |. .. |. |||||||||. | |.| .   ....  |  .| ..|.|.|. |  |.|. .|.|.|. ||.|||.
...leavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0039614 (Phosphotyrosine protein) phosphatases II 169-439 1.8e-73 242.9 In-house 22-289 (297) alignment 
Range on Protein: 169-439
Range on HMM: 22-289/297.0
AFKAAKMKCQAISKLHQDKIKGYMPPnCTYTAYEANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHM
...  |...  . .|.  ... . |. ..... ..| |.||| |. . . .||.||      .| |||.||.. .. . . ..| ||||||||. |||.|
llllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

IYQEKIAYVLMLCTLFEGGVeKCALYYPEKLGevvKFGKYEITLTECKEeaIAGTILNSLTVINtedaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYK
...... ...||..|.| |. ||| |.||. |   ..|.. .||.....   .| ..  |.| |    ..|.....|.|.. |||  .|.... ..|...
vweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn....ngesrtvthfqytgwpdhgvppslelllefle

WVKKVNP---KEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.|....    |..|..||||||||||.||......  .. .. .. .|..|.|.| .| .|||.  |. ||| .|.|..
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 169-439 9.7e-59 193.4 In-house 18-283 (290) alignment 
Range on Protein: 169-439
Range on HMM: 18-283/290.0
AFKAAKMKCQAISKLHQDKIKGYMPPNC-TYTAYEANP--DLNRYADVRCIEETRVVLKN-HDRDYIHASWMRmpGKdQSTYITTQGPLPETLSDFWHMI
| ...|.. . ..| . .|.| |.| .      ...|.    ||| || | . |||.||. .| ||.|| ...  |  ....| |||.| .|  |.| |.
asdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk..Gl.kamfiltqGalkdtvidiwrmv

YQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEeAIAGTILNSLTVINTEDATSEPLYmnHVQVPWWPDQLAPEDARPMIELYKW
 |||.|.. ||| |.| |  ||. ||||| |||. ||.. .. .| ..   | .|.. |.| . ..  .  |.  |...  |||.  .  .  .. . . 
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseedd.kdaniikktlsvrdkdsGkehklk..hlkikswpdksvalstlallrtlri

VKKVnpkEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
..|.     |. ||||||.||| ||| |. .   ...  ....||.|| .|  | ..||  .|.| |  .|... 
lrka...sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 170-454 9.3e-211 692.5 In-house 1-285 (285) alignment 
Range on Protein: 170-454
Range on HMM: 1-285/285.0
FKAAKMKCQAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
fkaakmkcqaisklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqeki

AYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||.|||||||||||||||||||||||||||||||||||||
ayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn

PKEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERTGQIDTF
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
pkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvvertgqidtf
0036941 (Phosphotyrosine protein) phosphatases II 170-451 4.2e-80 264.5 In-house 5-289 (297) alignment 
Range on Protein: 170-451
Range on HMM: 5-289/297.0
FKAAKMKCQAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKI
..  ..  . ..| ...  . . ...........| ..||| |. . . |||.|.. . |||.||.. ... ..  .| ||||||.|. |||.|......
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnv

AYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTILNSLTVINTedATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
  ..||..|.| | |||| |.|.. ||....|.. .||.....   .. .|  |.| .|   ..|.....| ... |||  .||...........|.||.
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkvl

P---KEKPICVHCSAGVGRTATFVGIDYATIRIM---ENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERTGQI
.   ...|..|||||||||..||...|..  ..    ..... .|..|...| .|..|||. .|..||| .|.|..    ..|.  ..
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 170-280 2.7e-08 27.7 In-house 3-112 (332) alignment 
Range on Protein: 170-280
Range on HMM: 3-112/332.0
FKAAKMKCQAIskLHQDKIKGYMPPNcTYTAYEANPDLNRYADVRCIEETRVVLKNHD--RDYIHASWMRMPGKdQSTYITTQGPLPE-TLSDFWHMIYQ
|||  ..   .  | | .      || ||  .  | |.||   . |.. .|| |  .|   |.  |||.    | .|.|| .| |. . |   ||.|. .
fkavtvegpel..lnqmhtsamtypn.tydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgysk.ksayifaqapfndhteyvfwrmvse

EKIAYVLMLCTLFE
 | . .|..  . |
rkpsmilvfgdide
0050432 (Phosphotyrosine protein) phosphatases II 173-439 1.5e-79 262.8 In-house 37-299 (308) alignment 
Range on Protein: 173-439
Range on HMM: 37-299/308.0
AKMKCQAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLkNHDRDYIHASWMRMPG-KDQSTYITTQGPLPETLSDFWHMIYQEKIAY
 ..  . ... ...  . . ........ ..| |.||| |. . . .||.| ... |||.||.....  | . ..| ||||||.|. |||.|...... .
kaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

VLMLCTLFEGGVEKCALYYPEKLG-EVVKFGKYEITLTECKEeaIAGTILNSLTVINTEDAtsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNp
. ||..|.| |.|||| |.|..|| .....||. .||.....   .. ..  |.. |..|   | ....| . . |||. .|............|.|.. 
IvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrksl.

KEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
...||.||||||||||.||. .|..  .. .. .. ....|. .| .| ..||. .|.|||| .|.||.
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0040438 (Phosphotyrosine protein) phosphatases II 174-439 2e-77 255.9 In-house 14-276 (317) alignment 
Range on Protein: 174-439
Range on HMM: 14-276/317.0
KMKCQAISKLHQDkIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKI
|. ..|... ..| .  . ...........|.|.||| |. . . .||.|.. .     |||.||.. .| . .  .| ||||||.|. |||.|......
ksdftalleefed.llslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgv

AYVLMLCTLFEGGVEKCALYYPEklGEVVKFGKYEITLTECKEeaIAGTILNSLTVINTedATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
 ...||..|.| |.|||| |.|.  ||....|.. .||....|   || .|  |.| ..   .||.....| . ..|||. .|.. ...... ..|....
tvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfleavreal

PK-EKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.. ..|..||||||||||.||......  .. .. .. . ..|.|.|..| .|||. .|. ||| .|.||.
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 174-439 3.4e-71 235.3 In-house 15-277 (278) alignment 
Range on Protein: 174-439
Range on HMM: 15-277/278.0
KMKCQAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKI
....... .|.  ..  . ...........| |.||| |. . . .||.|.. .     |||.||.. .. . . ..| ||||||||. |||.|......
llnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynv.prkfiatqgPlpetvedFwrmvwelgv

AYVLMLCTLFEGGVEKCALYYPeklGEVVKFGKYEITLTECKEeaIAGTILNSLTVINteDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN
  ..||..|.| |..||| |.|   |.....|.. .||.....   .. ..  |.| |    ..|... .|.. . |||. .||.  ......|.|....
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

P-KEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
. ...|..||||||||||.||......  ... . .. ....|.|.| .|..|||. .|. ||| .|.||.
edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 175-280 3.8e-16 53.5 In-house 8-118 (347) alignment 
Range on Protein: 175-280
Range on HMM: 8-118/347.0
MKCQAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHD---------RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIY
.|  ..|   .... .| |...|.. .| . . ||  ||. |..|||||   .           || || ...  . .  || || |||.|. |||.|..
ikeaslstyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd.naskeyiltqyplpdtvrdfwkmvs

QEKIAYVLmlcTLFE
  |.. |.   |.||
vtkvtqvv...tife
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 176-467 8.6e-37 121.5 In-house 17-305 (312) alignment 
Range on Protein: 176-467
Range on HMM: 17-305/312.0
KCQAISKlhQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLML
  | ..|  . |  | . ..   ||.    ||||| ...| .  |  |   .  |||| ....  | .  ...||||| .| . ||..      . ...|
tpqqltk..eykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkpe.rfvctqgplentcthfwqlalslgstsiill

CTLFEGGVEKCALYYPEKLGeVVKFGKYEITLTECKEEAIAGTILNSLTV--I-NTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKvnpKE
|.. | | |||| |  . .|  |..  . .    | |  | |   . .|   .     || .   .|| |   |||.  |.       |   |||     
cgfvedgsekcakyisdivg.fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...dk

KPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERTGQIDT-FMTQYKKHAQKKLA
||.  ||||||||| |.. |.     .    . .. |.   .|  | ..|.   |...   ...|..  .|. .|  |  | |   | |   ||| 
kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyakikakklk
0051299 (Phosphotyrosine protein) phosphatases II 178-439 2.1e-75 249.2 In-house 23-286 (288) alignment 
Range on Protein: 178-439
Range on HMM: 23-286/288.0
QAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVL
  . . ... .. .............| . ||| |. . . .||.|..    .. |||.||..... ...  .| ||||||.|..|||.|...... .. 
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqnvrvIv

MLCTLFEGGVEKCALYYPEklGEVVKFGKYEITLTECKEeaIAGTILNSLTVINT--EDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-
||..|.| |.|||| |.|.  |.....|.. .||.....   .. ..  |.| |.   | ..|... .| ... |||. .|............|.|... 
mltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

KEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
...|..||||||||||.||. .|..  .. ..  ...|..|. .| .|...||. .|..|.| .|.||.
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 178-439 6.4e-74 244.2 In-house 12-272 (273) alignment 
Range on Protein: 178-439
Range on HMM: 12-272/273.0
QAISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCT
. . . ... .. . . .........| |.||| |. . . .||.|.. . |||.||..... . .  .| ||||||.|. |||.|...... .. ||..
tllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrviVmLte

LFEGGVEKCALYYPEKLGE-VVKFGKYEITLTECKEeaIAGTILNSLTVINTEdaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP---KEK
|.| | |||| |.|.. || ....||. .||.....   .. ..  |.. |..  |.|.....|.... |||. .|..  ...|....|.|..    ...
lvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

PICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|..||||||||||.||. .|..  .. .. .. .|..|. .| .|. .||.  |..||| .|.||.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 178-440 2.8e-46 152.9 In-house 19-272 (288) alignment 
Range on Protein: 178-440
Range on HMM: 19-272/288.0
QAISKLHQDKIKGymPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRmPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCT
... | ..|  ..   .. . ... |||  .|| .. . . ||| |..    ||.|  .   .| .   | .| ||  |.  .|.|. .. . |..||| 
eglkkeyrdspne..asidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlce

LFEGGVEKCALYYPEKLGEVVKFGKYeITLTECKEEAIAGTIlnSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVkkvNPKEKPICV
| | | || | |.| |||| ...|..  | .  | . |  ..  ...... .  . |. .. .. .  |.|.  ||.  . . | . .   .  .||| |
llekGkeksaeyfPsklGekarigrl.ctvvkkkradidklv..kvsllriskegeekvivkilhlleWdddgvPenylsplrllevl...kslqkPivv

HCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
|.|||||||.|.. |  |   .  . .. .  .. ..|. ||.|.|. ||.|... ...|...
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0045098 (Phosphotyrosine protein) phosphatases II 180-439 7.2e-73 240.7 In-house 9-272 (278) alignment 
Range on Protein: 180-439
Range on HMM: 9-272/278.0
ISKLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVlknhdrDYIHASWMRMPgkdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLF
..  .. ..  . |  .|.  |. | |.||| |. ... .||.      |||.||.....   . ..| ||||||.|..|||.|.....| ...||..|.
lllefefllllgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelv

EGGVEKCALYYPEklGEVVKFGKYEITLTECKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDA--RPMIELYKWVKKVNP-------
|.|.|||| |.||  |... .|....||.....     ..   .| ...|... |.....|.. ..|||  .|..   ....||........        
elgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------KEKPICVHCSAGVGRTATFVGIDYATIRImeNPNIEMLDIVREMRAMRFQ-AVQSHMQFLFLYVVLMEYF
       ...|. ||||||||||.|.|....   ..  .... .|..|.|.| .| . |||. .|. ||| .|.|..
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 182-446 5.4e-33 108.9 In-house 25-286 (303) alignment 
Range on Protein: 182-446
Range on HMM: 25-286/303.0
KLHQDKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKnhDRDYIHASWMRMPGkdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEG
  . .|. .|.||. .   .  | | ||..|| |.. ..| |   |  |||||.. .    .   | || ||. | .||| || ..|.  ||.| |  | 
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasylelds..skkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GVEKCALYYPEKlGEVVKFGKYEITLTECKE-EAIAGTILNSLTVINTEDATSepLYMNHVQVpwWPDQLAPEDARP-----MIELYKWVKKVNPKEKPI
        .|..  . .|| .  | . | |. |   |  |. |.| | .  .   |.. | .   || .  | |. |     . .|   ..|  . . ..
dklggdsvfprn.qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhyka..wphnsipsdgspkfvkqiwqlqsvlrkysdstptv

CVHcSAGVGRTATFVGIDYATIRIM-ENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVE
 .   .|.||. ||  .. | . .  |.. ....  .  .|  |..|||   || ..| .| |. ...|...
yms.lsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngick
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 183-440 1.1e-30 101.4 In-house 24-280 (439) alignment 
Range on Protein: 183-440
Range on HMM: 24-280/439.0
LHQDKIKGYMPP---NCTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLML
   .||.   |.   ... .| | .   ||| ||   . |||.|..        || | ...    |.  ||.||||  ||  ||| .....| . ..||
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkkettddfwrlviekktvtivml

CTLFEGGVekcalYYPEKlgEVVKFGKyeITLTECKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEK--
. |.|        |.| .  . | .|   |..   ..  .   ..  . |.|  | |     . ...   |||.  | .|  .... . ..  | ||.  
tnlvesyk.....ywpsd..aevcygd..iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeyg

PICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
|. |||||||||| | . .| |  ..  . ....  ||. .|  | | ||.  |..|.|  ..|  .
pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
0045450 (Phosphotyrosine protein) phosphatases II 185-440 5.7e-72 238.3 In-house 23-305 (307) alignment 
Range on Protein: 185-440
Range on HMM: 23-305/307.0
QDKIKGYM-------------PPNCTYTAYEANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPGK-------DQSTYITTQGPLPETLSD
.| . |.              . .........| |.||| |. . . |||.|..     .| |||.||..|.|          . ..| ||||||||. |
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVKFGKYEITLTECKEeaIAGTILNSLTVINTeDATSEPLYMNHVQVPWWPDQLAPEDARPMI
||.|...... ...||..|.| | |||| |.|.. ||.. .|.. .||.. ..   .| ..  |.| .. | |.|... .| . . |||. .|..  ...
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeell

ELYKWVKKVNP---KEKPICVHCSAGVGRTATFVGIDYATIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
.... |.|..    |..|..||||||||||.||......  .. ...    . .|..|...|..| .|||.  |. ||| .|.|.. 
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 186-443 2.1e-39 129.9 In-house 34-294 (310) alignment 
Range on Protein: 186-443
Range on HMM: 34-294/310.0
DKIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLK---NHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGG
 |.     .  || ||. .   |||.|| | ...|| ||       ||||| ...     .||.| .||||  |. ||| ||.||.   .|.||   | |
rkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktn.ylrstficsqgplqhtiidfwrmifqeraesilllckvgeeg

VEKCALYYPeKLGEVVKFGKYEIT-LTECKEE----AIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIElYKWVKKVnpKEKPICV
  ||  |.|  ||    .|   .| |.|  ||     .| |..     .. . |  . | .. .. | |||.  |..    .   . . .|  .  |  |
rpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv..rhgpcvv

HCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEG
|||||..|. . | ....  .. .  .... ... |..  |.. .|...|.|..  | . .  || 
hcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarget
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 187-439 2.6e-29 96.9 In-house 23-293 (301) alignment 
Range on Protein: 187-439
Range on HMM: 23-293/301.0
KIKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNH------DRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFE
..| . . .|| .  |.|  |||. ..  ... |..||..       |.|| ||..    ...  .| .|||. .|| |||..|.||| . ..|.. | |
elkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy.sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke

GGVEKCALYYPEKLGEVVKFGKYEITLTEckEEAIAGTILNSLTVINTEDA-------------TSEPLYMNHVQVPWWPDQLA-PEDARPMIELYKWVK
|  .||  |.|.   |  .||. ..||..  | ..   .. .|.|. .. .             . ..  .  .||  ||..   .| .  .  . . ..
gtkskceqywpnseaeseefgpftvtlvn..eqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvih

K-VNPKEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
.   .   |. ||||..|.|. ... .. .      .  ... .... .|  .  ||.   |. ..| |. .|.
rqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
DSPc_SM00195 188-439 6.5e-75 247.2 In-house 10-262 (263) alignment 
Range on Protein: 188-439
Range on HMM: 10-262/263.0
IKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
 . . | ..| .. ..| . ||| .. ....||| ||. .     |||.|...... . ...|| ||||||.|..|||.|...||. ...||.  .| | 
eestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

EKCALYYPEKLGEVVKFGKYEITLTECKEEAiAGTILNSLTVINTEDatSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KEKPICVHCSAG
|||. |.||. |.  .|||....|.|....  . .||  |.. ....  .|.  ....|.  |||. .|.......||.. ||| .  ...||.||||||
ekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

VGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||||.||| ||..  .. |. .... .||.|.|  |...||...|.||.| ...||.
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 188-439 6.5e-75 247.2 In-house 10-262 (263) alignment 
Range on Protein: 188-439
Range on HMM: 10-262/263.0
IKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
 . . | ..| .. ..| . ||| .. ....||| ||. .     |||.|...... . ...|| ||||||.|..|||.|...||. ...||.  .| | 
eestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

EKCALYYPEKLGEVVKFGKYEITLTECKEEAiAGTILNSLTVINTEDatSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KEKPICVHCSAG
|||. |.||. |.  .|||....|.|....  . .||  |.. ....  .|.  ....|.  |||. .|.......||.. ||| .  ...||.||||||
ekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

VGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||||.||| ||..  .. |. .... .||.|.|  |...||...|.||.| ...||.
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_CG7180_pd Subfamily CG7180 188-440 1.5e-31 104.1 In-house 26-291 (296) alignment 
Range on Protein: 188-440
Range on HMM: 26-291/296.0
IKGYMPPNCTYTAYEANPDLNRYADVRCIEETRVVLK----NHDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
..     .|     . | . ||. .|   . .||||.    ... ||| |...    |..  || |..|  ||. .|| ..|.|.|  | .|.  |.   
tprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkk.eyivteapkketvdefWrlvydeeisavvvLtktfdfak

eKCALYYPEKLgeVVKFGKYEITLTECKEEAIAGTILNSLTV------INTEDATSEPLYMNHVQVPWWPD-QLAPEDARPMIELYK----WVKKV--NP
 ..  |.|.|     ..|. .. ..| |. |   .    ||        .... . |   . ..|.  |.  .  |  .  .||| .    |..||  .|
.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedp

KEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
.|.|..|..| |..|.  ...|| .   . .. .... . |. .|  | | |..  .. ..| || |...
eegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 190-440 5.7e-43 141.7 In-house 35-290 (305) alignment 
Range on Protein: 190-440
Range on HMM: 35-290/305.0
GYMPPNCTYTAYEAN--PD----LNRYADVRCIEETRVVLKN-HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGG
 |  |. | .|..||  .|     |||.|| | ... | |..    ||||| ..  |   .  .| .|||| .|. .|| |. |.|.  ..|||   | |
kytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelg

VEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKkvnPKEKPICVHCSAG
  ||| |.|   || ...    .         .       .|..|   . .. . . |.|   |||.  |      .||   ..     . || ||||||
klkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...gskvpivvhcsag

VGRTATFVGIDYATIRIMENPNI-EMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
.||| | | |.|   .| || .   | ..|. .|  |  ..|. .|.||.. |...||.
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_PTPRD_pd Subfamily PTPRD 192-441 4.7e-61 202.1 In-house 36-283 (564) alignment 
Range on Protein: 192-441
Range on HMM: 36-283/564.0
MPPNCTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCA
   ...  ...||   ||||..   ...||||..    .. ||| ||..      . .|| |||||.||..||| |....... . ||  | | | .||.
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkch

LYYPEKlGeVVKFGKYEITLTECkeEAIAGTILNSLTVinTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KEKPICVHCSAGVGRT
 |.||| |   ..|....||.|.  | .|  .. ....  ..  .||    .. .   |||. .|| |.....| . |...|. ...|| ||||||||||
kYWPek.g.tetygeltVtleee..eeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRT

ATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
 ||. ||.   || |. ....  .|...|. |   ||.. |. |.. ...|.   
GtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Ptp69D_pd Subfamily Ptp69D 192-440 5.7e-43 142.2 In-house 36-287 (307) alignment 
Range on Protein: 192-440
Range on HMM: 36-287/307.0
MPPNCTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCA
.. ... .. . |   ||| |..  ..|||.||.    .| ||| ||...   |.. ..|. |.|. .|. ||| || . ..  . ||  | |   .|||
idkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikg.ykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkca

LYYPEKlgEVVKFGkyEITLTECKEEAIAGTILNSLTVINTEDAT---SEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKEKPICVHCSAGV
 |.|.   . |..|  .|  .  .||     |  .| | .... .    .   .   .   |.|  .|| || ...| . |....  .. || |||||||
kYWpie..devqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGv

GRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
||...|| .|    .. .. .... ..|...|  |   |||  |. |||  |..|  
grsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0046845 (Phosphotyrosine protein) phosphatases II 193-439 3e-75 248.5 In-house 17-274 (284) alignment 
Range on Protein: 193-439
Range on HMM: 17-274/284.0
PPNCTYTAYEANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPG----KDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGV
  .........| ..||| |. . . .||.||.     .| |||.||......    . . ..| ||||||.|. |||.|...... .. ||..|.| |.
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

EKCALYYPEKlGEVVKFGKYEITLTECKEeaIAGTILNSLTVINTeDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK---EKPICVHCS
|||| |.|.. |||...|.. .||.....    . ..  |.. |. . |.|.....| ... |||. .|.......|....|......   ..||.||||
ekcaqYwple.gevltygdftvtllseev..kddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGVGRTATFVGIDYATIRIMENP---NIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||||||.||. .|..  .. ..    .. .|..|. .| .|...||. .|..|.| .|.||.
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 193-439 3.5e-36 119.3 In-house 25-269 (281) alignment 
Range on Protein: 193-439
Range on HMM: 25-269/281.0
PP-NCTYTAYEANPDLNRYADVRCIEETRVVLKN-----HDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKC
|   ||      |   |||... |.. .|| ||         ||||| ..| |      || ||||  || .|||.||.||. . ..||| . |   |||
psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflk.rgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

ALYYPEKLGEVVKFGKYEITLTECkeeAIAGTILNSLTVINTEdatSEPLYMNHVQVPWWPDQLAPEDARPMIelyKWVKKVNPKEKPICVHCSAGVGRT
| |.| .   ...| |. ..  .    ..  ... .   .  |    |   . |     |||   || .  |.   | ..|.  .  |  .||||||||.
aeyfprnahcclqfdklsvsyeds...tvnkslvttrlnlsye...getrlithwlwkewpdwqvpessevml...kilrkirarstppvihcsagvgrs

ATFVGIDYATIRIMENPNI-EMLDIVREMRA-MRFQAVQSHMQFLFLYVVLMEYF
 |.. .. |   |     . .. .||  .|   |  .||.  |..... ||... 
gtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
0040439 (Phosphotyrosine protein) phosphatases II 195-439 8.5e-67 220.7 In-house 2-246 (249) alignment 
Range on Protein: 195-439
Range on HMM: 2-246/249.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
..... ...|.|.||| |. . . .||.|.      . |||.||.. ..   .  .| ||||||||..|||.|.....| ...||..|.| | |||| |.
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PEklGEVVKFGKYEITLTECKEeaIAGTILNSLTVINTedATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP---KEKPICVHCSAGVGRTA
|.  |.....|.. .||.....   .. ..  |.. |.   ..|... .|.|.. |||. .|..  ........|.|..    |..|..||||||||||.
pl..ggsleygdftvtllsvev..kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
||......  .. .. .. ....|...| .|..|||.  |. ||| .|.|..
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 195-439 6.2e-61 201.4 In-house 1-242 (243) alignment 
Range on Protein: 195-439
Range on HMM: 1-242/243.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKNhdRDYIHASWMRMPGkdqsTYITTQGPLPETLSD----FWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
....  ...| . ||| |. . . .||.|..   |||.|.......    ..| ||||||||. |    ||.|.....| ...||..|.| |.|||| |.
sfsiallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PeklGEVvKFGKYEITLTECKEeaIAGTILNSLTVINtEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKK---------VNPKEKPICVHCSA
|   |||  .|....||.....   .. ..  |.. |  |.. ....  |..   |||. .|..  ..... ..|..         ......|..|||||
p...gev.tygdftvtllseeh..lddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRTATFVGIDYATIRImenpNIEMLDIVREMRAMRFQ-AVQSHMQFLFLYVVLMEYF
|||||.|.. ...   ..    .. ....|...|..|.. |||.  |. ||| .|.|..
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 195-440 6.7e-55 181.4 In-house 37-284 (305) alignment 
Range on Protein: 195-440
Range on HMM: 37-284/305.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
 .  .  |||   ||....   .. |. |..    .|.||| ||..    | . .||..||||..|..|||..|..||.  ..||. | ||| .||  |.
sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYW

PEKLGEVVKFGKYEITLTEckEEAIAGTILNSLTVINTEDaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE--KPICVHCSAGVGRTAT
||. .|...||.....|..  |..... |   |.. . ..  .|   . . |.  |||.  |. |  ...|.| |.|   |.  .|. |||||||||| .
pesktekkefgefsvelks..ektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
|. .| |  |. .   ... ......|  | ..||.  |. ||. .| |. .
fiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN13_pd Subfamily PTPN13 195-437 3.8e-51 169.0 In-house 28-267 (273) alignment 
Range on Protein: 195-437
Range on HMM: 28-267/273.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRdYIHASWMRMP-GKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEK
.|. .  ..| | ||| .|  ..|||| |...   || ||....| |||. .|| .||||||| .||| |... |   . |. .  |.|  ||  |.||.
tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

LGEVVKFGKyEITLTECKEEAIAGTILNSLTVINTEdaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVGID
 .. .|     ....  | .   |  ...|.|...|  ..|   . |..   |||   |  | ..... . |.... .. || ||||||.||. |.. ||
knkklkvsn.rlevellkvqkldgfvvralavkdse..sgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitid

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 .   |  . .... .|||..|  |   ||.. |..| | ...|
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRA_pd Subfamily PTPRA 195-449 4.4e-47 155.6 In-house 49-306 (330) alignment 
Range on Protein: 195-449
Range on HMM: 49-306/330.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRmPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
 .  .. | | . ||. ..   . .||.| .     . ||| ||..    |.. ..|..|||. ||. ||| ||.. | | ..||  | |   |||| |.
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid.GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PEKlgEVVKFGKYEITLTECKeEAIAGTIlNSLTVINTEDAT--SEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-KPICVHCSAGVGRTA
|..   .| .|.  ... ... .... |.   . | .  |||   ..  .. .    |||   | ... |..| | |||.|...  || |||||||||| 
Pde..GlvtyGnirvevedet.vlvdytv.rkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

TFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF-IGEGVVERTG
||. .|    |.  .  ... ..|...|. | | ||. .|. |.| ||.||.  |.  .. . 
tfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss
subfamily_PTPRG_pd Subfamily PTPRG 195-460 2.5e-44 146.4 In-house 38-310 (563) alignment 
Range on Protein: 195-460
Range on HMM: 38-310/563.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKNH-----DRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALY
... .  . |   ||| ..  ....|| |..      . ||| |...    . .  .|.|||||..|. |||.||.... | . |.  | | | .||  |
daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy.qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvY

YPEklGEVVKFGKYEITLTEckEEAIAGTILNSLTVIN----TEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-KPICVHCSAGVG
.|.   |....|. ..||.|  || .|    ..|.. |     .. . . . . . . . |||. .|| . | .   |  .. |..|  || ||||||||
WPk..desetygalqvtlie..eevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvg

RTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERTGQIDT--FMTQYKK
|| |.. .|  . .| ..  ........ .||.|   ||.. |..||. .|.|   ..     . |..     | | .
rtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelknctpyle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 195-439 1.1e-43 144.3 In-house 38-278 (287) alignment 
Range on Protein: 195-439
Range on HMM: 38-278/287.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKL
. | .  . | |.||....   .. ||.||... ||| |...    |..  .| ...|. .|. .||..| ....  ..||| . |   |.|  |.||. 
evthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidg.ykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

GevVKFGKYEITLTEckEEAIAGTILNSLTVINTEDaTSEPLYMNHVQVPWWPDQL-APEDARPMIELYKWVKK-VNPKEKPICVHCSAGVGRTATFVGI
   | .|.|.|.|..  ||  || |   | |.|..  ..... ..  |.  |...   .| .  .. . . .|.   . . .| ||||..|||.|.|. .
s..vvlGeynielln..eevnagyierklevknknk.agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaa

DYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
. .  .  ..  |.........|  . ..||   |. |.. ...|| 
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 195-445 8.9e-43 141.8 In-house 52-298 (319) alignment 
Range on Protein: 195-445
Range on HMM: 52-298/319.0
NCTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCtlfeggVEKCALYY
. |..  . | | ||. ..   ....| |.. .     ||| ||..    . .  ||..||||..|| ||| ||.. ... ...|        .||. |.
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy.qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqyw

PEKLgeVVKFGKYEITLTECKEEAIagTILNSLTVINTEDATsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE---KPICVHCSAGVGRTA
| |   |.| ..... ..  .| |    .. .. . .    . .   ..      |||.  |. . ... | | |.... ||   ..| |||||||||| 
plki..vikeerfkvkvdsveetae..yvvrdielsedgkek.dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtG

TFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME-YFIGEGVV
... .|    |. |.  ... ..||..|  | . ||. .|. |.|. |.| ...|   |
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_PTPRN_pd Subfamily PTPRN 195-436 1.1e-32 108.0 In-house 45-289 (297) alignment 
Range on Protein: 195-436
Range on HMM: 45-289/297.0
NCT--YTAYEANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCAL
..|   .  | | . ||...|   ...|| ||..    . ||| || .      ...||.|||||..|..||| |.... .. ...|..| | ||..|. 
pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YYPEKLGEVvkFGKYEITLTEckEEA-IAGTILNSLTVINTEDATSEPLYMNHvqVPWWPDQLAPEDARPMIELYKWVKKV-NPKEKPICVHCSAGVGRT
|.|..  ||  .. ||. |    |       .. |. . | .   .  .   |     ||.. .|  |....|. . | |    .  || ||||.|.|||
ywpdeGsev..yhiyevhlvs..ehiwcddylvrsfylknlqtsetrtvtqfh..flswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrt

ATFVGIDYATIRIMEN-PNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLM
 ... ||    |..    .|..   .  .|  | . |... || | . .. 
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
0042113 (Phosphotyrosine protein) phosphatases II 196-439 1.4e-65 216.4 In-house 1-243 (245) alignment 
Range on Protein: 196-439
Range on HMM: 1-243/245.0
CTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
........|.|.||| |. . . |||.|....     |||.||.. ..   .  .| ||||||||. |||.|.....| ...||....| | .||| |.|
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

EklGEVVKFGKYEITLTECKEeaIAGTILNSLTVINTedATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP--KEKPICVHCSAGVGRTATF
.  ||....|.. .||....    .. ..  |.| |.   ..|..  .|..   |||. .|.. . .......|.|.    ...|..||||||||||.||
l..gesltygdftvtllseeh..lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
......  .. .. .. . ..|.|.| .| .|||.  |. ||| .|.|..
iaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 196-439 9.8e-52 170.8 In-house 34-290 (297) alignment 
Range on Protein: 196-439
Range on HMM: 34-290/297.0
CTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
 ...   ||   |||.|| |..||||||.. |     |||.|...    | . ..|.|||||..| |||| |......  ..|   . | |  ||. |.|
flasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdG.ykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

EKLGEVVKFGKYEITLTECKEEaiAGTILNSLTVINTEDATSEplYMNHVQVPWWPDQLAPEDARPMIELYKWVKK--------------VNPKEKPICV
.. ... .||.....  | .||       ..|.. |...  |    . | |.  |||   |..|  .... . |..               .|.. || |
leeessaefgdlsvsnveveee..edykvrvleiknvkteesr..kvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|||||.||| ||. .|..  |. |  .... . |. .|. |  ..|   |. | |. ..|| 
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 196-439 7.4e-49 161.5 In-house 40-283 (319) alignment 
Range on Protein: 196-439
Range on HMM: 40-283/319.0
CTYTAYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
 . .  | | . ||| ..  .. |||||..    .. ||| ||..    .... .| ||.|| .|..||| |...|..  |.||. | | .  |.  |.|
fdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp

EKlgEVVKFGKYEITLTEckEEAIAGTILNSLTViNTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK--EKPICVHCSAGVGRTATF
|.  .....|.. .|| |  ||  .. |   |.. |.  .  |   . | |   |||.  ||.|. ...|.| ..|   |  ..|| |||||||||| ||
ee..nfeeyGrlivtlee..eeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
. .| .  |. |.  ...  .|...|. |   || . |. |.| .|.|. 
ivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPN1_pd Subfamily PTPN1 196-437 3.8e-43 142.3 In-house 24-269 (290) alignment 
Range on Protein: 196-437
Range on HMM: 24-269/290.0
CTYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
.. .  ..| .|||| ||.  . .|..|...| ||| || . ..   .  || ||||||.| . ||.|....|   |.||  . | .  ||| |.|..  
treaklpenrnlnryrdvspydhsrikleradndyinaslveleea.krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-EVVKFGKYEITLTECKEEAIAGTILNSLTVINTEDATSEPlyMNHVQVPWWPDQLAPEDARPMIELYKWVKK---VNPKEKPICVHCSAGVGRTATFVG
 . ... . .....  .||     ... | . | .   .    . |     |||   ||    ....   |..   ....  |  .|||||.||. ||. 
ekellledtklkvkliseerksyytvrllelenlktqetre..ilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IDYATIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
.|   ..| .. .   ... . . |.| .|.  .|   |. | |. ..|
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 196-446 1.6e-42 140.9 In-house 17-263 (284) alignment 
Range on Protein: 196-446
Range on HMM: 17-263/284.0
CTYTAYEANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCtlfeggVEKCALYYP
 |..  . | | ||. ..   ....| |.. .     ||| ||..    . .  ||.|||||..|| ||| ||.. ... ...|        .||. |.|
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy.qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

EKLgeVVKFGKYEITLTECKEEAIagTILNSLTVINTEDATsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE---KPICVHCSAGVGRTAT
 |   |.| ..... ..  .| .    .. .. . .    . .   ..      |||.  |. . ... | | |.... ||   ..| |||||||||| .
lki..vikeerfkvkvdsveesee..yvvrdielsedgkek.dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME-YFIGEGVVE
.. .|    |. |.  ... ..||..|  | . ||. .|. |.|. |.| ...|   | 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 196-442 1e-40 134.7 In-house 43-287 (297) alignment 
Range on Protein: 196-442
Range on HMM: 43-287/297.0
CTYTAYEANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMpgkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVeKCALYYP
 | .    | . .||...  ..  || |.      | ||. ||...     .  .|||| | ..|. ||| |...|... ..||  . |.   ||| |..
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg...nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

EKlgEVVKFGKYEITLTECKEeaIAGTILNSLTVINTEDATSepLYMNHVQVPWWPDQLAPE--DARPMIELYKWVKKVNP--KEKPICVHCSAGVGRTA
.|   |..||.  ..|.  .|    | |  .|.| . .  .     ..  |   |||.  ..  .|. ...| . |.|.    .| |. |||.||||||.
dk..gvttfGdvsvvllsvse..reGfikrelevtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

TFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGE
 .. ||    .. .. .......|. .|  | . || . |. |.||...|... |
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_PTPN14_pd Subfamily PTPN14 196-439 2.2e-40 133.5 In-house 41-296 (300) alignment 
Range on Protein: 196-439
Range on HMM: 41-296/300.0
CTYTAYEANPDLNRYADVRCIEETRVVL---KNHDRDYIHASWMRMP-GKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYP
.. .. . | . ||. ||   |..|| |   |. . .|| || .... |  . .||..||||. |. |||.|....... ..||    |.| ||.  |.|
lstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfP

EK--LGEVVKFGKYEITLTECKEEAIAGTIlnSLTVINTedATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK----------EKPICVHC
..    . |.|||...|    ..     |.  .|..      ..|   . |.|   |||.  ||| .....  . |. |  |          . |. |||
kleskkktvefgkfkvttkfsedsdsvitt..glklkhl..pskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

SAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|||||||   .  |  .  .  | .|..  ... .|  |   ||.  |. |.| ||..|.
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0049772 (Phosphotyrosine protein) phosphatases II 196-438 6.7e-37 123.3 In-house 38-279 (314) alignment 
Range on Protein: 196-438
Range on HMM: 38-279/314.0
CTYTAYEANPDLNRYADVRCIEeTRVVLKN---HDRDYIHASWMRMPgkdqSTYITTQGPLPETLSDF----------WHMI--YQEKIAYVLM------
..   ...|.| ||| |. . . .||.|..   .. |||.||... .     ..| |||||..|. ||          |.|.  .. .. .. |      
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LCTLFEGGvekcALYYPEKLGEVVkfgkyeitlteckeeaiagtilnsltvintEDATSEPLY----MNHVQVPWWPdQLAPeDA
               |..| ..|    ... .. | .                                |  .. .|.    ......|..    || . 
adelsrLdaAlgKtpllildgng....neptaadlellk..............................eelydpelferlgikylripvpD.gsap.ll

RPMIELYKWVKKVnPKEKPICVHCSAGVGRTATFVGIDYatirIMENPNIEMLDIVREMRAMRF-----QAVQSHMQFLFLYVVLMEY
. . |........ .|..|. |||.||.|||.||| ..|    .|   .. . ......|..|.      .... .|..| . .|.||
edfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaay....lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_PTPRB_pd Subfamily PTPRB 197-439 2e-53 176.3 In-house 44-285 (293) alignment 
Range on Protein: 197-439
Range on HMM: 44-285/293.0
TYTAYEANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPE
. .  ..| . ||| ..   ...|| |    .... ||| |....   . .  .|.||||||||. |||.|....|   ..||  |.|.| .||  |.|.
kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy.nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPa

KLGEVvKFGKYEITLTecKEEAIAGTILNSLTVINtedaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN---PKEKPICVHCSAGVGRTATF
.  .|  .|. ..||.  .||     .. .|.. .    ..|   ... .   |||   ||........ . |...     ...|| |||||||||| ||
deepv.lyGdikvtlv..aeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
. .|  . .| |.  .... || |.|  |.. ||.  |..|.. ......
ialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 197-440 3e-48 159.2 In-house 36-277 (515) alignment 
Range on Protein: 197-440
Range on HMM: 36-277/515.0
TYTAYEANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPE
| .  | |   ||| ..  .. .|| |     | . ||. || ..    |  .||..|||.. ...|||....||... . |.  | ||   ||. |.|.
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

KLGEVVKFGKYEITLTEckEEAIAGTILNSLTVINTEDATSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-KEKPICVHCSAGVGRTATFVG
| |. ||||.... |     || .|.|   |||.  .|.      .   .   |||. .|.... .. | | ||  .   . |. .|||||||||  .. 
kpgdsvkfGsikvelvs..leactggikrkltvlkgddsrt....vtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

IDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
||    .. .   ......|. .|. | . || . |. |.| ...|.. 
idsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 197-439 9.4e-44 144.4 In-house 39-283 (290) alignment 
Range on Protein: 197-439
Range on HMM: 39-283/290.0
TYTAYEANPDLNRYADVRCIEETRVVLK--NHD----RDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
|.   . |  |||.|..   .. |..|.  . .     .||.|...    |..  || ||||...|| |||..|.|||.. ..||..  | | .||  |.
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PEKlgEVVKFGKYEITLTecKEEAIAGTILNSLTVINTEDAtSEPLYMNHVQVPWWPDQL-APEDARPMIELYKWVK-KVNPKEKPICVHCSAGVGRTAT
|..  .. ..|...|.|.  .||.. . |   | | |.. |  ..  . . |.  |...   .. .  .. ... .| .  . ...| ||||..|||.|.
pds..dtkaygefsikll..neetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsav

FVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|. .. .  .   .  |.........|  . . ||.  |. ... ....|.
fcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 197-437 4.6e-43 142.1 In-house 26-264 (283) alignment 
Range on Protein: 197-437
Range on HMM: 26-264/283.0
TYTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMR--MPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKl
. .. . |.  ||. ..   .  || ||.. |||| |...      |..  || .|.|| .|  |||.|...|||. ..||  | |.  .||. |.|.. 
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.

GeVVKFGKYEITLTecKEEAIAGTILNSLTVINTEDATSEPLyMNHVQVPWWpdqLAPEDARPMIEL--YKWVKK--VNPKEKPICVHCSAGVGRTATFV
|  ...|.. .||   || .    |   |.. .   | |. | . | ||  |   |  ..  ..  |  .  |.    . |. || ||||.|.||||.|.
G.sedyGeftvtlr..kettsnsfiikelllrvnssakstll.lahyqvidW...leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

GIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
..  .   .. .  ...  .|. ||  |  |||.  |. ... . .|
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN3_pd Subfamily PTPN3 198-434 8.1e-56 184.0 In-house 35-270 (280) alignment 
Range on Protein: 198-434
Range on HMM: 35-270/280.0
YTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRM--PGKDQS-TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEkL
 .   .| . ||| |.   ..||| ||. . ||| |... |  |.....  ||.|||||..| .|||.|....|.  ..|| || | |  ||  |.||  
aarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.t

GEVVKFGKYEITLTECkeEAIAGTILNSLTVINTEDATSEplYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKEKPICVHCSAGVGRTATFVGID
.. ...|.........  ..    .|  |.. ..|   .    . ..|   |||.  |.|.  ..|. . |.|.   ||.|. ||||||.|||  .. ..
edeleygefsvkceke..detksyvlrelvlkdketkeer..kilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVV
 |   | .. .. .|||||.||  |   ||.. |. |.   
talalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPN23_pd Subfamily PTPN23 198-437 1.2e-46 153.8 In-house 37-278 (288) alignment 
Range on Protein: 198-437
Range on HMM: 37-278/288.0
YTAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEV
 .. . ... ||. |.   ...||.|...  ||| ||...       ..|.||.||..||.||| |.|..|   . || .  | | .|.. |.||. || 
iaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

VKFGKYEITLTECKEEaiAGTILNSLTViNTEDaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKK-----VNPKEKPICVHCSAGVGRTATFVgI
||||....|| . .|      .   |.. .|.| ...   . |.|.  ||.  .|.    .... . |..      .. ..|. |||||||||| .|  .
vkfgdlsvtlksvret..ethvervlkl.etld.adavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa.l

DYATIRIMENPN--IEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 || .| .|. |  ......|. .|. |   || . |. |.| . .|
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 198-441 8.7e-29 95.1 In-house 39-238 (392) alignment 
Range on Protein: 198-441
Range on HMM: 39-238/392.0
YTAYEANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGvekcalyypek
 .  | |   ||| ..  ....||.|       |.||. ||...    .  .||..||| . .|.|||.|..||... . |.  | ||            
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

lgevvkfgkyeitlteckeeaiagtilnsltviNTEDATSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-KPICVHCSAGVGRTATFVGI
                                 . .|| .    .   ..  |||.  |. .  .... | ||    .  .|. .|||||||||.  . |
.................................kgddart....vaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
|    .  .   ......| ..|  |   ||.. |. |.|  ..| .. 
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 199-439 1.5e-53 176.8 In-house 36-276 (281) alignment 
Range on Protein: 199-439
Range on HMM: 36-276/281.0
TAYEANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKL
.  ..|   ||| ..   . |||..    .|.. ||| |...    |..  ||.||||.|..| .||.|....|.  . |.    |.|  ||  |.|.. 
skadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn

GeVVKFGKYEITLTEckEEAIAGTILNSLTVintEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEK--PICVHCSAGVGRTATFVGI
   .|.|.. .. |.  ||. |  |   ...   |  ..|.  .....   |||. .|.... ..|  | |.|.. |..  |...||||||||| |....
s.elkygdvtvksta..eeekatyierkfkl...eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyial

DYATIRIME-NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
| .  .. . ...... ..|.|.|  |   ||. .|. |.| ......
Drlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 199-439 1.2e-26 87.8 In-house 46-285 (302) alignment 
Range on Protein: 199-439
Range on HMM: 46-285/302.0
TAYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPGKDQSTYItTQGPLPETL---SDFWHMIYQEKIAYVLMLCTLFEGGVeKCALYYPEKLG
.|. .|.. |.  ||.......| |...  .|..|| . .|   .|... .| |  ..     .||.|..||||. | .|    |        ..|.| |
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

EVVKFGKYEITLTEckEEAIAGTIlNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWV-KKVNPKEKPICVHCSAGVGRTATFVGIDY
. ...||  .       |   ..  . ...    .  |. . .|   .  |...  |.    .|.  . | .|  . .... .    |.|| ..|.    
dykeygkmfvNnrk..Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlav

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|  .. .. . .. .||. .|. | .||.|  |. .||..|. |.
aveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_PTPN12_pd Subfamily PTPN12 200-439 2.1e-55 182.7 In-house 36-277 (290) alignment 
Range on Protein: 200-439
Range on HMM: 36-277/290.0
AYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
  | |   ||| |.   ...||.|..    .. ||| |.... . . . .|| .|||||.||.|||.||.. ..  |.|.| ..| |  ||. |.||. .
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

EVVKFGKYEITLTEckEEAIA-GTILNSLTVINTedATSEPlyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK-EKPICVHCSAGVGRTATFVGID
| ..||..|.||.|  |.|.  . .. .|.| .    .|    ..  .   |||.  |. | ...|| . |.... . ..|..|||||||||| | . ||
eelefgefevtlee..ekavdddflirtLkveaq..kesrk..vyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

YATIRIME---NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|.   . .   ...... |.|.|.|  |  .||.. |. ..|  ..|..
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 200-439 2.2e-51 169.9 In-house 52-290 (298) alignment 
Range on Protein: 200-439
Range on HMM: 52-290/298.0
AYEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
 ...| . |||||.  .. .||||..    .. ||| ||..    |.....|.||.||.||..|||.|. .|.|. . || .| | .  |.  |.|..  
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhay.kgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk

EvvKFGKYEITLTecKEEAIAGTILNSLTVINTEDAtsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEK--PICVHCSAGVGRTATFVGID
|  ..|. ...|   ..|  |  |   |.| ... .  .   . ....  |||. .|| |. ...| ..|.. . . .  |. |.|||||||. ||. ||
e..tygeitvsll..skeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
    |. ..  ......|. .|. | .|||.. |. |.| . .|..
svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 200-438 2.1e-49 162.9 In-house 16-263 (270) alignment 
Range on Protein: 200-438
Range on HMM: 16-263/270.0
AYEANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG
..  .. ||||||.    .|||.|..        || | ..|   ... .||...|||| ||..|| ||..||   ..|.  | | | .||. |.|.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

EVVKFGKYEITLTECKEEAIAGTILNSLTVIntEDATSEPLYmnHVQVPWWPDQLAPEDAR------PMIELYKWVKKVNPKE---KPICVHCSAGVGRT
| ||. . .|. . ..||   | ||  |..   |..... |   | .   |||. .|...        .... . |.... .    .|. ||||||||||
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRt

ATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEY
 |.. .|.|.  . |. ....| |..|.|  | . ||   |. ||| ...||
GtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 200-441 1.9e-30 100.8 In-house 29-259 (267) alignment 
Range on Protein: 200-441
Range on HMM: 29-259/267.0
AYEANPDLNRYADVRCIEETRVVLKNHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEkcaLYYPEKLGEVVK
  | | . ||. |.   ..|||.|......|| ||..    | . ..| ||.||  | .||. .| ..|.. . .| . |.. .    |..| |.|.  |
iaeknqernrlddnlpyddtrvilrtkeeeyinasyvegy.ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnir...lfwPPkmgqakk

FGKYEITLTECKEEAIAGTILNSLTVINtEDATSEPLYMNHVqvpWWPDQLAPEDARPMIELYKWvKKVNPKEKPICVHCSAGVGRTATFVGIDYATIRI
.    .  .  |||     |   | . | | |    ||  .    |  .       .|.. .    ....  ..|. |.||.||||. ||. ||    |.
yqdltvehslekeendyqiitlelkfkn.esahnvtlyyykk...wnintnnkpylkplfgilak.nqlengnrPlvvacsdGvGrsGtflvidsqlera

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYfiG
 ..   .. | .|..|  |   |..  ...... .| ||   
ktegvsdifdflrkirsqriglvdtkeryiyihellaey..a
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 201-442 5.4e-49 162.0 In-house 43-283 (318) alignment 
Range on Protein: 201-442
Range on HMM: 43-283/318.0
YEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgE
 ..|   ||||..   ..||| |..    .. ||| |...    . . .|| .|.|||||..||| |... . | ..||  . | | .|.. |.|.|  .
epvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy.rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..g

VVKFGKYEITLTECKEeaIAGTILNSLTVINTEDatSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN--PKEKPICVHCSAGVGRTATFVGIDY
  ..||  ..|.| .|  ..  .| ...| .||   .|   .   ..  |||.  ||..  ...| . |.|..  ....|| |||||||||| .|. .| 
srsygklvvelkeeve..lsdyvlrefkvtrtee..eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdi

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGE
   || ..  ......|...|  |   || . |. |.| ||.|. .  
llerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 201-440 2.6e-46 152.9 In-house 41-278 (315) alignment 
Range on Protein: 201-440
Range on HMM: 41-278/315.0
YEANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGE
 . |   ||| ..  ....||.|    .. |.||| || ..   .|  .||..||||. ...|||.|..|||.. . |.  . ||   ||. |.|.. ..
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

VVKFGKYEITLTECkeEAIAGTILNSLTVINTEDATSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKV-NPKEKPICVHCSAGVGRTATFVGIDYA
 |.||.....| .   || ....   |.. ..|.       .   |   |||. .....  ...| | ||   ..|| .. ||||||||||  .. ||  
svefGsikvellsl..eadtdgvarklvtrkseesrt....vtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

TIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFI
  .| ..  ......|...|| | . ||.. .. |.| ...|.. 
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRK_pd Subfamily PTPRK 201-450 3.5e-42 139.3 In-house 40-289 (314) alignment 
Range on Protein: 201-450
Range on HMM: 40-289/314.0
YEANPDLNRYADVRCIEETRVVLKNHDRD----YIHASWMRMpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGE
 . | . ||. |.   . .||.|.  | |    || |...    |  . .| |||||.||. ||| ..|.|. | ..||  | | |  ||  |.||. .|
kdenreknrsgdilaydrsrvflitidgdpssdyinaalids.ykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.te

VvkFGKYEITLTECkeEAIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK-EKPICVHCSAGVGRTATFVGIDYA
|  .|. ...| |.  |. |  .   ..| ... . .|   ....|   |||   |  |. ...| . ||| ... . .| |||||| ||| ||. ||  
v..ygdikvelvet..ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

TIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME-YFIGEGVVERTGQ
   | ..  ...  .|...|. .   |. . |. |.| |..|  . ||  .  .  
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsef
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 201-441 2.3e-38 127.1 In-house 45-290 (325) alignment 
Range on Protein: 201-441
Range on HMM: 45-290/325.0
YEANPDLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKiAYVLMLCTLFEGGVEKCALYYPEKLGE
  .| . ||. .|  ....||||.      . ||| ||..|   |.. .....| ||..|. |.| .... . . |...   ...| ..|| |.|...|.
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgk

VVKFGKYEITLTECkeEAIAGTILNSLTVINTEDAtsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP-------KEKPICVHCSAGVGRTATF
 ..||  |. |     | |.  .   | | ....   | . ..  |.  |.|   ..    .| . . ||.|.           || |||||||||| .|
sktfGglevklrti..eeisdyvhrvldvkqvkkG..etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

VGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
. .  |  ...|. ...... |. .|. | . |..  |. ..|  |.|... 
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_ptpA1_pd Subfamily ptpA1 201-391 5.5e-23 76.4 In-house 44-248 (418) alignment 
Range on Protein: 201-391
Range on HMM: 44-248/418.0
YEANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRmpGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGE
 . |   |||...  .. ||| ||.       ||| | ..   |     .| ||||||.|..|||.|.....   ..||    |    ||  |.||..| 
kkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid..gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

V---------VKFGKYEITLTECKEEAIAGTILNSLTViNTEDATSEplyMNHVQVPWWPDQLAPEDARPMIELYKWVKK----VN---PKEKPICVHCS
            || | . | |  ..     |   . .   |  | .   . . |   |||.  |. ..|. .| . . .    .     .. || ||||
eqfsiygngnevfgtysvelveviqdpereiitrnirl.tfegetrd...itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGVGRTATFVG
|||||| ||. 
agvgrtgtfct
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 202-439 2.4e-55 182.6 In-house 45-279 (288) alignment 
Range on Protein: 202-439
Range on HMM: 45-279/288.0
EANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEV
  | . ||| ..  ..|.|| ||.    .. ||| ||..   .| . .||.|||||..|. |||...|..|.  ..||  | ||| .||  |.|.. .. 
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkp

VKFGKYEITLTECKEEaiAGTILNSLTVIntedATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-KPICVHCSAGVGRTATFVGIDYAT
...|. ..||.| ||.    ..|..| .      . . | ... |   |||.  ||...|..|| . ||  |... .|| |||||||||| ||. .| . 
knyGsvtvtlveskel..edfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali

IRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 .. |.  |.....| ..|  |.. ||   |. |.| ||..  
daveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 203-439 4.1e-47 155.5 In-house 8-242 (250) alignment 
Range on Protein: 203-439
Range on HMM: 8-242/250.0
ANPDLNRYADVRCIEETRVVLKNHD----RDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEkCALYYPEKLgeVV
.| . |||||.  ....||||....     ||| ||..    .  ...|.|||||..|. ||| |...||.. ..|| .| | . . .  |.| .     
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..ae

KFGKyeITLTECKEEAIAGTILNSLTVINTEDATSepLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPK--EKPICVHCSAGVGRTATFVGIDYAT
|.|.  .|..  ..|  |  .   | . ... | .    . ...   |||.  || |. ..|| | |.. ...  ..|. |.|||||||. .|. ||   
kyGd..vtvsllskeefadytkrklklskakkade..rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

IRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 |. ..  ... .... .|. | .||.|. |. |.| ..... 
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN6_pd Subfamily PTPN6 203-439 1.9e-45 150.2 In-house 53-297 (306) alignment 
Range on Protein: 203-439
Range on HMM: 53-297/306.0
ANPDLNRYADVRCIEETRVVLKNH---DRDYIHASWMR--MPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEV
 |   |||  .   ..|||.||..   . ||| |. ..  ..|.|  .||.||| |..|.||||.|..||.   ..|. .  | | |||| |.|..  . 
enkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

VkFGKYEItlTECKEEAIAGTILNSLTVINTeDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-----KPICVHCSAGVGRTATFVGI
  .||...  |...|.. |  || .|.| .. .  .|  .. . .   |||.  |.|   .... . |.. . .       ||.||||||.||| ||. |
e.yGkisv..tnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DYATIRIMEN---PNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|  .  |...    .|.. ..|. .|. | . || . |. |.| .. .| 
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 203-441 7.5e-41 135.1 In-house 48-281 (315) alignment 
Range on Protein: 203-441
Range on HMM: 48-281/315.0
ANPDLNRYADVRCIEETRVVL----KNHDRDYIHASWMRMPGKdQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgeVV
 | . ||| ..   ...|| |    .. . ||. |...    | .  ||..|||..... ||| ....|.|. ..||  | ||  .|.  |.|.|    |
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynk.krryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv

KFGKyeITLTECKEEAIAGTILNSLTVINTEdATSEplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE-KPICVHCSAGVGRTATFVGIDYATI
 .||  ||.|  .||        .|.|.  .    |   .  ...  |||   |. . |...|.. ||. . ..  .| |||||||||| ||. .|    
iyGk..itvtrkseevnteytvrtlsvvfgd.nire...vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld

RIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
..  .  |.. .... .|..| ..||.  |. |.| .|.| |. 
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 203-439 3.8e-31 102.9 In-house 37-277 (287) alignment 
Range on Protein: 203-439
Range on HMM: 37-277/287.0
ANPDLNRYADVRCIEETRVVLK---NHDRDYIHASWMRMPgKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVK
|.   ||||||  |..|||.|    ..  ||| | ..    .|. ..|..|||.. |. ||| ...... | |...    | .  ||  |.||.    ..
aavkknryadvlPiddtrvllsaegelGsdyinanyvasy.tddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

FGKYEITLTECKEEAIAgTILNSLTVINTEdaTSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWV------KKVNPKEKPICVHCSAGVGRTATFVGID
 | | ..| . .          .| .|. |  | |   .. ...  |||. ..  |  .| .   |      ..   .  |. ||...|.||. ... . 
vGGysvvlldydikePe.ygvralrlidle..trearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

YATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
    |  .  ....  .|  .|  |   ||. .|. .||  |. |.
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_egg_pd Subfamily egg 203-452 9.7e-30 98.3 In-house 39-281 (307) alignment 
Range on Protein: 203-452
Range on HMM: 39-281/307.0
ANPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRmpGK-DQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGgvEKCALYYPEKLGEV
 | .  |   |.| . .|| |.     .  |.|||  ..  ||    ..| .| || .|  ||| |..||.. |..|| .  |   |.|  |.|    . 
nnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

VKF--GKYEITLTECKEEAIAGTILNSLTVINTEdatSEPLYMNHVQVPWwpdqlapEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVGIDYA
...  | ..|.  . ...|     .  | .. ..    | ....| |  .       . .  .   .. ..|.    ||. |..  || ..||.| |. |
lvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdv.......nnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieia

TIRIMENPNIE--MLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFigEGVVERTGQID
 . ..  |     .|  |  .|  |  .|.| ...||.| ... .|    |.  . ..|
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff..rdvigsakeld
Y_phosphatase Protein-tyrosine phosphatase 204-437 9.5e-71 233.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 204-437
Range on HMM: 1-235/235.0
NPDLNRYADVRCIEETRVVL--KNHDRDYIHASWMRMPGkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFG
| . ||| |. ....||| |  .... |||.|.....   .....| |||||..|..|||.|..|||. .. ||..| | | |||| |.||. .| ...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

KYEITLTeCKEE-AIAGTILNSLTVINTEDATsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKEKPICVHCSAGVGRTATFVGIDYATIRI
.....|.  ||. . ....|. |.. .... . |.  ......  |||. .||.......| . |.| . .|..|..||||||||||.||| .|..  ..
dikvelk.ekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 .. ....|.||.|.|. |...|||  |. ||| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 204-437 9.5e-71 233.3 In-house 1-235 (235) alignment 
Range on Protein: 204-437
Range on HMM: 1-235/235.0
NPDLNRYADVRCIEETRVVL--KNHDRDYIHASWMRMPGkDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFG
| . ||| |. ....||| |  .... |||.|.....   .....| |||||..|..|||.|..|||. .. ||..| | | |||| |.||. .| ...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

KYEITLTeCKEE-AIAGTILNSLTVINTEDATsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN-PKEKPICVHCSAGVGRTATFVGIDYATIRI
.....|.  ||. . ....|. |.. .... . |.  ......  |||. .||.......| . |.| . .|..|..||||||||||.||| .|..  ..
dikvelk.ekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 .. ....|.||.|.|. |...|||  |. ||| ...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 204-437 1.8e-46 153.2 In-house 50-279 (301) alignment 
Range on Protein: 204-437
Range on HMM: 50-279/301.0
NPDLNRYADVRCIEETRV-VLKNHDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGK
. | .||  | |  .| | |...  |  ||| |.  .|. .  .|.|||||..|  ||| |. | ..  . ||.   |  .|||. |.| | .| .. |.
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhph.rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

YEITLTECKEEAIAGTILNSLTVINTEDAtSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKvnpKEKPICVHCSAGVGRTATFVGIDYATIRIMEN
..|.... .      ..  .| | .. .   ..  . | |   |.|.  |.    . .| . |||    |||| ||||||.||. .|.| .| . ..  .
fkikiknkelilnkkiskrtlevedstgk.fatrtvthyqysewtdrgvPkshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteylarevead

PNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
|.||. . ....|  |...|| . |. .. .  . 
ptieltealkhlrehrwngvqtnsqlywmtlGtvy
0041856 (Phosphotyrosine protein) phosphatases II 204-441 9.2e-43 141.3 In-house 1-173 (182) alignment 
Range on Protein: 204-441
Range on HMM: 1-173/182.0
NPDLNRYADVRCIEETRvvlknhDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCtlfeggvekCALYYPEKLgevvkfgky
| |.||| |. ... .|      | |||.|...... ...  .| |||||..|. ||..|.....| ....|.         . ||.||.|         
nldknrysdilpydhsr......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywpell.........

eitlteckeeaiagtilnsltvintedatsePLYMNHVQVPWWPDQLAPEdarpMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVGIDyatirIMENP
                               . .  ...   |||  .|.    . ||......|. ...|. ||||||||||.|.|...     .|.  
...............................erlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaay.....lmkkl

NIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIG
.. . ..|...| .|...|..  |. ||. .|.|.. .
gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 204-437 1.9e-34 113.9 In-house 8-239 (239) alignment 
Range on Protein: 204-437
Range on HMM: 8-239/239.0
NPDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgeVVK
|   ||||..   . .||||..       ||| ||..|       .||.||| .  .  |||.|..||. . ..||  | ||  .||  |.|.      |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

FGKYEITLTecKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVpwWPDQLAPEDARPMIELYKW-VKKVNPKEKPICVHCSAGVGRTATFVGIDYATIR
. .  .||   | | .|  |. .. . .  ..    .|  |. |  |||.  |. |  .. | .   |   |  .|  .||||||||| .|. ||    .
ycnlrvtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
  ..  ..... |. .|  | . ||.  |..|... ..|
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 205-437 1.6e-34 114.1 In-house 8-238 (239) alignment 
Range on Protein: 205-437
Range on HMM: 8-238/239.0
PDLNRYADVRCIEETRVVLKN----HDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgeVVKF
   ||||..   . .||||..       ||| ||..|       .||.||| .  .  |||.|..||. . ..||  | ||  .||  |.|.      |.
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsky

GKYEITLTecKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVpwWPDQLAPEDARPMIELYKW-VKKVNPKEKPICVHCSAGVGRTATFVGIDYATIRI
 .  .||   | | .|  |. .. . .  ..    .|  |. |  |||.  |. |  .. | .   |   |  .|  .||||||||| .|. ||    . 
cnlrvtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

MENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 ..  ..... |. .|  | . ||.  |..|... ..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 206-439 2.9e-49 162.6 In-house 30-268 (274) alignment 
Range on Protein: 206-439
Range on HMM: 30-268/274.0
DLNRYADVRCIEETRVVL-----KNHDRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGE--VV
  ||| ..   |..||.|     ...| .|| | ... ..... .|. ||||||.|..|||.|||||..  ..||  | |   .||| |.|.. .     
tknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeise

KFGKYEITLTECKEEaiAGTILNSLTVINTEDATSeplyMNHVQVPWWPDQLAPEDARPMIELYKWVKKVN----PKEKPICVHCSAGVGRTATFVGIDY
..|. ||. .. .|.   .  ...|.. ..|.  |    . |   . |||. .|.||.....| . |.. .     |  |. ||||||.|||  |..|. 
rygdveikvekiver..ndysvrklvlkylerers....vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|  .. |.  ...| || ..|  |   ||.. |. ... .|..| 
avrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 206-448 9.5e-45 147.6 In-house 50-296 (305) alignment 
Range on Protein: 206-448
Range on HMM: 50-296/305.0
DLNRYADVRCIEETRVVLKN-HDRDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYE
. ||| || |... || |..    .|||| ..  | . .  .| || || .| .|||.| .|.|. ...||| | | | .||. |.. | ..|..| . .
gknrykdvgcldnnrvklegpwpheyihanyvstptnpk.rfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

ITLTECKEEAIAGT------ILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELykwVKKVNPKEKPICVHCSAGVGRTATFVGIDYATIR
  ..   | . .           . ||.  | . .. . ..|     |||.  |     ..||   ..|  |   || ||||||.||| . | ..|   .
qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailel...lekarpskgpivvhcsagigrtgsvvmleyildq

IMENPNIEMLD-IVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGEGVVERT
...   ||  | |.. .|  | ...|.  |.||.. |...||  ..... .
llagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 206-460 7.1e-33 109.0 In-house 20-272 (290) alignment 
Range on Protein: 206-460
Range on HMM: 20-272/290.0
DLNRYADVRCIEETRVVLKNHDR----DYIHASWMRMPgkDQSTYITTQGPLPET-------LSDFWHMIYQEKIAYVLMLCTLFEGGVE----KCALYY
.... ..|  .|.||||||.. .    |||||. . .|  .    | || |. ..       . .|| |. |||.  | |||   |   .     || |.
emdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcp..nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PEKLGEVVKFGKYEITLteCKEEAIAGTILNSLtVINTEDatSEPLYMNHVQVPWWPDQLAPEDARPMIELykwVKKVNPKEKPICVHCSAGVGRTATFV
||. || .||.  ..    .. |.  . .   | |.. .|   |.. ..| ..  | .  ..|| . ...|   ..||. .. |. |||  |. | |.. 
pesvgeelkfkgltvkC..kskekeddvetRel.vvkfdd..eeeftvtHsllkgWnklnvqedtktllsl...iqkvkasktpvivHcvdGiSrsAala

GIDYATIRIM-ENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMeyfigegvVERTGQIDTFMTQYKK
 |. .   |.  . .... |.. ..| .| .|..|.... |   ...        .  .   |.|......
aiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv........llaievldqfaeeete
subfamily_CG42327_pd Subfamily CG42327 206-361 6e-19 62.8 In-house 30-186 (319) alignment 
Range on Protein: 206-361
Range on HMM: 30-186/319.0
DLNRYADVRCIEETRVVLKNH----DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLG--EVVK
| .|...|  . ||||||..        |..||..| . . .. ||..| .| .. |||| .... .   .. |. |.| |...|| |.| | .  .   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FGKYEITLTECkeEAIAGTILNSLTVINTEDATSEPLymNHVQVpWWPDQLAPEDARPMIEL
.|.. .|| .   |.    .. .| . . ..  | .|   |     |..   | . ...| .
yGdilvtlkgr..evkdryaistlllkrvdkeesrel..thywy.kwleaevPaeeaaliam
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 207-436 3.6e-34 113.0 In-house 6-236 (237) alignment 
Range on Protein: 207-436
Range on HMM: 6-236/237.0
LNRYADVRCIEETRVVLKNH--DRDYIHASWMRMPGKDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVKFGKYE
 |||..... . .|||||    . ||| |....       .||..||||  .  ||| |..||| . ..||  | ||  .||  |.|.   .   .|.. 
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvlt

ITLteCKEEAIAGTILNSLTVINTEDATsEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNP---KEKPICVHCSAGVGRTATFVGIDYATIRIME
..|  .|.|...   . ||.. .      |  ..   |   |||.  |. .  .. . | . . .|   .  |  .|||||||||. |. ||    .  |
vsl..kkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

NPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLM
.  ... . |  .   |   .|.. |..|.. ...
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 207-355 7.2e-24 79.2 In-house 36-183 (297) alignment 
Range on Protein: 207-355
Range on HMM: 36-183/297.0
LNRYADVRCIEETRVVLKN--HDRDYIHASWMRMPGKDQS-TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKY
 ||| |.   ..||| |..   .|||| | .. .| ...   || .|||| .|. |||...... .  . |.. | |.| .||| |.|.  .|  | |..
knryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdv

EITLTECKEEAIAGTILNSLTVINTedatSEPLYMNHVQVPWWPDQLAPEDA
 .       .     ||  |..|      ||  ...|||   |||   | | 
vveflsstsdefdrviltelqliyr....sesrvvrhvqflswpdhGvpsdl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 208-439 4.9e-28 92.8 In-house 51-344 (350) alignment 
Range on Protein: 208-439
Range on HMM: 51-344/350.0
NRYADVRCIEETRVVLK---------NH---DRDYIHASWMRMP--GKD--QST-YITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYY
||| ..   | .|| ||         .|     ||| |......  ...   .  || ||.|||.|. ||...|.. |.  .|.| ...| ..|||  |.
nrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYW

PEKLGE--VVKFG--------KYEITL--TECKEEAI-------AGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQ---LAPEDARPMIE--------
.|   .   ||.           ...|  .. |.||           . .  .... . |.|.|. . ..||  |.|    | ||.  ...|        
qegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndlidd

LYKWVKKVNPKEKPICVHCSAGVGRTATFVGIDYATI--RIMENPN-----I----E----MLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|.      | . .|| |||||||||| |.| .|.      |.|| .     .    .    .  || |.|  | . ||.  ||.|.|  |. ||
lfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
0044763 (Phosphotyrosine protein) phosphatases II 217-438 3.5e-31 103.6 In-house 3-170 (178) alignment 
Range on Protein: 217-438
Range on HMM: 3-170/178.0
EETRVVLKNHDR----DYIHASWMRmPGkdqsTYITTQGPlpetlSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGevvkfgkyeitltecke
..|||.| |  .    |||.||..  ||     |.....|     .|.. ......| ....|.. .|.| .||  |.||. |                 
drtrvllsnleglersdyinaseil.pg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

eaiagtilnsltvintedatseplyMNHVQVpWWPDQLAPEDARPMIELYKWVKKVN-PKEKPICVHCSAGVGRTATFVGIDYATIRimenpNIEMLDIV
                         ......  .||  .|.  . . |........  .|..|. |||||||||..|.| ...   .     .. . ...
.........................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

REMRAMRFqAVQSHMQFLFLYVVLMEY
...|..|. .|..  |  .|| . ...
elvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 221-438 2.8e-38 126.8 In-house 5-172 (176) alignment 
Range on Protein: 221-438
Range on HMM: 5-172/176.0
VVLKNHDRDYIHASWMRMPgkdqsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVkfgkyeitlteckeeaiagtil
.   . | |||.|... ..      .|.||||||.|| ||..|.....| .|..|....| |  ||. |.||  .. .                      
llgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

nsltvintedatseplymnHVQVPWWPDQLAPEDaRPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVGIDyatirIMEN-PNIEMLDIVREMRAMRF
                   ....  |||  .|.. . ..||.......  . .|. ||||||.|||.|.| ..     ..|   .. ........|..|.
...................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRp

-QAVQSHMQFLFLYVVLMEY
 .|||.  |  ||| .....
lgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 226-432 3.9e-38 126.2 In-house 3-154 (172) alignment 
Range on Protein: 226-432
Range on HMM: 3-154/172.0
HDRDYIHASWMRMPGKDQStYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnsltv
...|||.||.. .. . .. .| |||||..||.|||.|.....| ....|..|                                               
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel...............................................

inTEDATSEPLYMNHVQVPWWPDQLAPeDARPMIELYKWVKK--VNPKEKPICVHCSAGVGRTATFVGIDYATirimenPNIEMLDIVREMRAMRFQAVQ
  . |.. .  .  ...   |||. .| ... ..|.......  .. ...|..||||||||||.|.| ...         .. ....|...|..|..|||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

SHMQFLFLY
.  |  |||
npsqyrfly
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 226-310 2.2e-11 37.7 In-house 88-168 (349) alignment 
Range on Protein: 226-310
Range on HMM: 88-168/349.0
HDRDYIHASWMRMPGKD-QSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlgevvKFGKYEITLTEC
   ||| | .....  . .  ||.|| ||| |. ||...|  ...  || |   .| ..|||  |. |      ..  ... | . 
klddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel.....sysnitvklqns
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 226-324 6.6e-07 23.7 In-house 11-101 (130) alignment 
Range on Protein: 226-324
Range on HMM: 11-101/130.0
HDRDYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLctlfeGGVEKCALYYPEKlgEVVKFGKYEITLTECKEEAIAGTILNSLT
.. .||.||.. . |.  . |. || || .|  |||.|. .  .  ...|     | ||.   |.|.   | ... . .|..|  . .       . | 
qgntyinasfvGllgrt.aeylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpds..ePlewyeediivtltdrdefknikasnle
0036282 (Phosphotyrosine protein) phosphatases II 228-432 1.6e-37 124.2 In-house 2-163 (174) alignment 
Range on Protein: 228-432
Range on HMM: 2-163/174.0
RDYIHASWMRMPGKDQsTYITTQGPLPetlsdFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEklgevvkfgkyeitlteckeeaiagtilnsltvin
 |||.||.. .       .| .||||.     ||.|.....| .|.||....| | .||  |.||                                   
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

teDATSEPLYMNHVQVPWWPDQLAPEDARpMIELYKWVKKVNPK--EKPICVHCSAGVGRTATFVGIDYATIRIMeNPNIEMLDIVREMRAMRFQAVQSH
  . ...  .  ...   |||  .|...  ..|..|.|...  .  ..|. ||||||||||.|.|....   ... .. .. ||.|||.| .| ..||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

MQFLFLY
 |. |||
sQyrfly
0051429 (Phosphotyrosine protein) phosphatases II 228-453 5e-37 123.4 In-house 4-252 (272) alignment 
Range on Protein: 228-453
Range on HMM: 4-252/272.0
RDYIHASWMRMPgKD---QSTYITTQGPLPETLSDFWHMiYQEKIAYVLMLCTLFEGGVEKCALYYP----------EKLGEVVKFGKYEITLTECKEEA
 .||.|... ..        ... ..|||| |  |||.. ....| ....|....| | .|| .| |          .   . . .|.. .||....   
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

IagtILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPEDArpMIELYKWVKKvnpkEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIE--------
    ..    ..  .  ..|.. . | .   |||  .|..|  ..|| ... .    ..|. ||||||..||.|.| ...   .. ..  ..        
d...yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

MLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYFIGE-------------GVVERTGQIDT
....|.|.||.| .|||. .|.|||| .|.|.. .               . |. | ...
leeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyGsveg
0051082 (Phosphotyrosine protein) phosphatases II 228-436 1.4e-27 91.6 In-house 3-150 (151) alignment 
Range on Protein: 228-436
Range on HMM: 3-150/151.0
RDYIHASWMRmPGkdqstYITTQGPLPetlsDFWHMIYQEKIAYVLMLCTLFEGGveKCALYYPEKLgevvkfgkyeitlteckeeaiagtilnsltvin
 |||..|..  .|     .. ..|||.    ||. ......| ....|....| |  .|. |.||                                   
sdyinfsyvt.gg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tedatsepLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKvnPKEKPICVHCSAGVGRTATFVGIDYATIRimenpnIEMLDIVREMRAMRFQAVQSHMQ
        .   |.... |||.  |.    ..|. ... .  .|..|. ||||||.|||.|.|...    .      . . ....|.|..|. .||...|
........ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

FLFLYVVLM
|||.. .|.
flfqlfall
subfamily_eak_pd Subfamily eak 228-321 2.5e-11 37.6 In-house 78-166 (332) alignment 
Range on Protein: 228-321
Range on HMM: 78-166/332.0
RDYIHASWMRMPGKDQsTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITlteCKEEaIAGTILN
  || || . ..   .  || |  .  . .  || |....|   ...|    | ..||   |.|.|  |..|||.....   .||  .   ||.
lGyinaslaefsevGr.kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve...rkef.vkrnile
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 229-316 1.2e-06 22.4 In-house 123-202 (244) alignment 
Range on Protein: 229-316
Range on HMM: 123-202/244.0
DYIHASWMRMPGKDqSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLctlfeGGVEKCALYYPEKlgEVVKFGKYEITLTECKEEAIA
 || ||..   |.  . || || || .|  |||.|. . ..  ...|     | ||.   |.|.   | ... . .||.|    . . 
tyinasfvgclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpds..eplewyeeditvtltdrdefk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 238-436 5.2e-33 108.8 In-house 83-285 (302) alignment 
Range on Protein: 238-436
Range on HMM: 83-285/302.0
MPGKDQSTYITTQ--GPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGTILNSLTVI-----NTED
| | ..   .. .   |  .||  .| .| | ..| |  ||.. |.. .||| || .|.|...|||.| ..  . |..    |  .|...      |.. 
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

ATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVnpkEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLF
 .  .  .. ..   |||  ||..| . ... |. .      | . |||||||||| |.| | |     ...   ..|.||  .|. |. |||.. | ..
kkkvkktvdilafsawpdhGapkeaytaldilkfcesy...kknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

LYVVLM
| ... 
lllcvt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 241-433 5.2e-15 50.1 In-house 2-198 (199) alignment 
Range on Protein: 241-433
Range on HMM: 2-198/199.0
KDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEaiAGTILNSLTVINTEDATSEPLYMNH
| |  ||.|| || ||..||| |...    ...|.           ..|.|     . |.|   .|      .  .   . .| . |   |      . |
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittk..pdytitaliltnnttappstreish

VQVPWWPDQLAPEDARP--MIELYKWVKKV--NPKEKPICVHCSAGVGRTATFVGIDYAtIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYV
 |   | .. .|. |    ..   . | |   . |. |. |||| | | |  || .|   .|  |. .   ...... . .|  |   . |  .. |.| 
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldig.vrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 241-433 7e-15 49.7 In-house 1-197 (198) alignment 
Range on Protein: 241-433
Range on HMM: 1-197/198.0
KDQSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEaiAGTILNSLTVINTEDATSEPLYMNH
| |  ||.|| || |||.||| |...    ...|.           ..|.|     . |.|   .|      .  .   . .| . |   |      . |
kgqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittk..pdytitaliltnnttappstreish

VQVPWWPDQLAPEDARP--MIELYKWVKKV--NPKEKPICVHCSAGVGRTATFVGIDYAtIRIMENPN---IEMLDIVREMRAMRFQAVQSHMQFLFLYV
 |   | .. .|. |    ..   . | |   . |. |. |||| | | |  || .|   .|  |. .   ...... . .|  |   . |  .. |.| 
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldig.vrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 242-448 4.5e-30 99.6 In-house 33-230 (255) alignment 
Range on Protein: 242-448
Range on HMM: 33-230/255.0
DQSTYITtqgplpeTLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTEckeeAIAGTILNSLTVINTEDATSEPLYMNHV
 ...|.        |.  |...| | |   | ||| . | |||||  |.| .. |  |. . ..| |.    ..|  .|  |... |     .   ..| 
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhy

QVPWWPDQLAPEDARPMIELYKWVKKVnpkeKPICVHCSAGVGRTATFVGIDYA------TIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVL
.   |... |||.|| . ...| |..     |.. ||||.|.||.|.|| ....      ...  |  ... | ...|.| .| .|..  .|. |  ...
sykGWieknaPelareilnilkvvrds....ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv

MEYFIGEGVVERT
....  .| .|  
ldlvfpkgeleak
subfamily_hpo-7_pd Subfamily hpo-7 243-441 2.6e-26 87.1 In-house 37-229 (263) alignment 
Range on Protein: 243-441
Range on HMM: 37-229/263.0
QSTYITtqgpLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEeaiaGTILNSLTVINTEDATSEPLYMNHVQ
...|.     | .|.  |...| | |   | |||   | |||||  |.| .. |  |. . ... |. ..     ..| .| ...| .   .   ..| .
knlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhys

VPWWPDQLAPEDARPMIELYKWVKKVnpkeKPICVHCSAGVGRTATFVGIDYA------TIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLM
   |... .||.|| .... | ...     |.. ||||.|.||.| |. .. .      ...  .  ... | ...|.| .| .|..  ||. |  ....
ykgWiekndpelareilnilkvarns....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

EYFIG
.... 
dfvln
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 243-305 2.6e-06 21.0 In-house 235-293 (440) alignment 
Range on Protein: 243-305
Range on HMM: 235-293/440.0
QSTYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEggvEKCALYYPEKLgEVVKFGKYEI
. ..|.|| ||  |. ||| .... .|. ..||  | .     |..|.| .    | || . .
knafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt.rsvtfgpftv
0049260 (Phosphotyrosine protein) phosphatases II 245-432 3.7e-34 113.0 In-house 10-143 (152) alignment 
Range on Protein: 245-432
Range on HMM: 10-143/152.0
TYITTQGPLPETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYpeklgevvkfgkyeitlteckeeaiagtilnsltvintedatseplymnHVQVP
 .| ||||.|.||.|||.|... .| ...||..|.| | .||. |.                                                 ...  
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qylhl

WWPDQLAPEDARPMIELYKWVKK-VNPKEKPICVHCSAGVGRTATFVGIDYATirimenPNIEMLDIVREMRAMRFQAVQSHMQFLFLY
.|||  .|...  ...|.....|    |..|. ||||||||||.|.| ...         .......|. .|..| .||... |  |||
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 257-439 2.9e-12 39.9 In-house 131-309 (346) alignment 
Range on Protein: 257-439
Range on HMM: 131-309/346.0
LSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKlGEVVKFGKYEITlteCKEEAIAGTILNSLTVINTEDATSEPLYMNHVQVPWWPDQLAPeDAR
. |||.|||||.|  | ..           .|.  |. |     ||  |     .   ..|   .    .  |  .   .   | . ||   |  |  . 
vedfwymiyqeqihlvylmvpddklkntttslfnden.ggyqytgkmfin...nrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqpp.ktl

PMIEL-YKWVKKVNPKEKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
|.| . ...  . . ..  .||    | ||. .|.|  ||  .. .  . ....|.....  |  .|.|  |.  .| ....| 
piikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
0048179 (Phosphotyrosine protein) phosphatases II 324-433 5.8e-21 70.2 In-house 35-139 (144) alignment 
Range on Protein: 324-433
Range on HMM: 35-139/144.0
TVINTEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVGIDyatirIMENPNIEMLDIVREMRAMRFQAVQ
..... . ...  .  ...   |||  .|...  ..|........ ....|. ||||||||||.|.| ..     .|   .. . ......|..|..||.
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay.....lmkklglsleealalvrsrrpgavp

SHMQFLFLYV
.  |. ||. 
npgqlrfLle
PTPc_motif_SM00404 325-429 1.8e-08 29.4 In-house 34-131 (140) alignment 
Range on Protein: 325-429
Range on HMM: 34-131/140.0
VINTEDATSEPLYMNHVQVPwWPDQLAPEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVgIDYatirIMENPNIEMLDIVREMRAMRfQAVQS
|... ..|.|   ....|.|   |.   . .. . .... ..... |.. . ||| ||| |.||.. | |    .|.  .... . .. ..  | .... 
vteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli.iaY....lmryrqlslaeayefvkerR.piisp

HMQFL
 ..|.
nlnfv
0048076 (Phosphotyrosine protein) phosphatases II 328-438 3.4e-22 74.1 In-house 37-142 (145) alignment 
Range on Protein: 328-438
Range on HMM: 37-142/145.0
TEDATSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVGIDyatirIMENPNIEMLDIVREMRAMRFQAVQSHMQ
| . . .  .  ...   |||  .|.... ..|........ ....|. ||||||||||.|.|...     .|   .. . ......|..|..||..  |
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay.....lmlllgvsleealelvrsqrpgavpnpgq

FLFLYVVLMEY
. ||| ...|.
lrflyefelel
PTPc_DSPc_SM00012 338-437 4.5e-30 99.3 In-house 2-105 (105) alignment 
Range on Protein: 338-437
Range on HMM: 2-105/105.0
MNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKE---KPICVHCSAGVGRTATFVGIDYATIRIMEN-PNIEMLDIVREMRAMRFQAVQSHMQFLFLYV
..|.... |||. .||.. ...|| . |||.. |.   ||..||||||||||.||| .|..  .....  ......||.|.| .| ..||. .|.|||| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLME
.|.|
alle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 338-444 2e-11 37.9 In-house 93-199 (440) alignment 
Range on Protein: 338-444
Range on HMM: 93-199/440.0
MNHVQvpWWPDQLAPEDARPMIELYKWVKKVNPK--EKPICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVL
  | |   |||.  |. | |.... . |.. . |  . |. ||||||.|||.  . .|        . .|... ..  ||  | | ||.  |. |.. ..
qyhyq..gwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

MEYFIGEGV
.| ..   .
legllcgdt
DSPc Dual specificity phosphatase, catalytic domain 339-429 9.7e-08 27.0 Pfam-A 41-124 (133) alignment 
Range on Protein: 339-429
Range on HMM: 41-124/133.0
NHVQVPwWPDQLAPEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVgIDYatirIMENPNIEMLDIVREMRAMRfQAVQSHMQFL
.....|   |.   . .. . |... ..|.  |.| . ||| ||. |.||.. | |    .|.  |... . .. ..  | ...   ..||
eylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknlslneAyefvkerr.skispnagfl
DSPc Dual specificity phosphatase, catalytic domain 339-429 9.7e-08 27.0 In-house 41-124 (133) alignment 
Range on Protein: 339-429
Range on HMM: 41-124/133.0
NHVQVPwWPDQLAPEDARPMIELYKWVKKVNPKEKPICVHCSAGVGRTATFVgIDYatirIMENPNIEMLDIVREMRAMRfQAVQSHMQFL
.....|   |.   . .. . |... ..|.  |.| . ||| ||. |.||.. | |    .|.  |... . .. ..  | ...   ..||
eylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknlslneAyefvkerr.skispnagfl
0038934 (Phosphotyrosine protein) phosphatases II 345-428 1.7e-08 29.8 In-house 86-166 (194) alignment 
Range on Protein: 345-428
Range on HMM: 86-166/194.0
WWPDQLAPEDARPMIELYKWVKKVNPK--EKPICVHCSAGVGRTATFVGIDYatiriMENPNIEMLDIVREMRAMRFQAVQSHMQF
 .||. .. .   . . ...|.... .  .. . ||| ||.|||.|.|.        ..  .. . . .. .| .|  |...  ..
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdyl
PTEN_1 346-390 2.3e-06 22.5 In-house 102-148 (196) alignment 
Range on Protein: 346-390
Range on HMM: 102-148/196.0
WPDQLAPEDARPMIELYKWVKKVN--PKEKPICVHCSAGVGRTATFV
..|  ||  .. . .....   .   |... . ||| ||.||..| |
ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 367-435 6e-09 30.2 In-house 223-291 (297) alignment 
Range on Protein: 367-435
Range on HMM: 223-291/297.0
KVNPKEKPICVHCSAGVGRTATFVGIDYA--TIRIMENPNIemLDIVREMRAMRFQAVQSHMQFLFLYVVL
   |.. .. |||||||||.   |  |     .|    |..    |.. .|  | . ||.  || .|| . 
aemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdv..aailsilreqrarlvqtleqfellydav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 370-439 1.7e-06 21.6 In-house 263-344 (349) alignment 
Range on Protein: 370-439
Range on HMM: 263-344/349.0
PKEKPICVHCSAGVGRTATFVGIDYATIrIMENPNIEM-------------LDIVREMRAMRFQAVQSHMQFLFLYVVLMEYF
 .  .. |||||| ||| ..| .|.    |.| .. |.               || |.| .|.. ||   || ..|  |..||
dqlstllvhcsaGcGrtGvlvtldllls.ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_CG42327_pd Subfamily CG42327 372-438 1.3e-11 38.8 In-house 247-314 (319) alignment 
Range on Protein: 372-438
Range on HMM: 247-314/319.0
EKPICVHCSAGVGRTATFVGIDYAtIRIMENP--NIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLMEY
  |. |||| ||||| . .  | | || .|..   ... ..|  .|  | .||..  |. |.| || ||
qGPlvvhcsdGvGrtGlviasdia.irsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 376-437 1.3e-07 25.9 In-house 2-63 (69) alignment 
Range on Protein: 376-437
Range on HMM: 2-63/69.0
CVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
 ||||.| ||| ||. |     ||  .  ..... |. ||  |   |   ....|..  |.|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 377-437 3.4e-07 24.5 In-house 2-62 (69) alignment 
Range on Protein: 377-437
Range on HMM: 2-62/69.0
VHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME
||||.| ||| ||. |     ||  .  ..... |. ||  |   |    ...|..  |.|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve