Gene F57H12.5 in Caenorhabditis elegans

Synonym: CELE_F57H12.5, F57H12.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP101_AA protein Get Run
CeleP101_AA_203-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 193-505 4.9e-50 166.0 In-house 16-302 (308) alignment 
Range on Protein: 193-505
Range on HMM: 16-302/308.0
KHSKQKTKMWLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKT--TEAFEANKVRNREGCPKIYDENRVQLnrpgHEDVNYINASVITltdvcrrmacv
. | ......| . . |....| .|.....|||  | |. .. .  . ....|| .||     .|| .|| |    .|. .||||| ..           
dtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvd...........

payvhlvvlyfvI--FQFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPDDKLK-NTTTSLFNDENG-GYQYTGKMFINNRRADVSGDPKEYT
            .  . ...| |..| |    .. ||||| |.........  .   .  . ..    . .| | |... ||....... .| .| . .|
............gyssklprkfIatqgPl...pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrt

IEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVE
.|. . |...| .... |.  |.. . ||.. ........  .    ..  ..| .  |.||.. || ......||. . .....|..| ...|||| |.
leltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvq

SFAQYASIYAIVFDYIARK
.. ||  .| ....|. .|
tpeqylflyralleylklk
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 194-539 6.7e-251 824.6 In-house 1-346 (346) alignment 
Range on Protein: 194-539
Range on HMM: 1-346/346.0
HSKQKTKMWLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEAFEANKVRNREGCPKIYDENRVQLNRPGHEDVNYINASVITLTDVCRRMACVPAY
|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||.||.|||||||||
hskqktkmwlgmpsalnfcnknndiqkireefgfldslvcnkttedfeankvrnregcpkiydenrvqlnrpghedvnyinasvitlkdvsrrmacvpay

VHLVVLYFVIFQFEHKLIVAQLPQMENESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEG
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
vhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpeg

NSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYAS
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
nsdsvicqvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyas

IYAIVFDYIARKRGGKKAPVNKDINRFIDELAEISPACSPTKVMPL
||||||||||||||||||||||||||||||||||||||||||||||
iyaivfdyiarkrggkkapvnkdinrfidelaeispacsptkvmpl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 195-287 3.2e-06 20.8 In-house 3-92 (302) alignment 
Range on Protein: 195-287
Range on HMM: 3-92/302.0
SKQKTKMWLGMPSALNFCNKnNDIQKIREEFGFLDSL-VCNKTTEAFEANKVRNREGCPKIYDENRVQLNrpgHEDVNYINASVITLTDVCRRM
 ..... | .   |... ..  | .....||  .|.. |     .|| .|  .|.    .|.|.|.|.|.   .|  .|.||| ... .. | .
veeekekWveeeeakklvks.ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsi
0039614 (Phosphotyrosine protein) phosphatases II 196-506 1.1e-50 168.1 In-house 9-293 (297) alignment 
Range on Protein: 196-506
Range on HMM: 9-293/297.0
KQKTKMWLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEAFEANKVRNREGCPKIYDENRVQLNRPGH--EDVNYINASVITLTDVcrrmacvpay
..   ..|..  .|....| |.......||  | ||...... ....|| .||     .|| .||.|. ...  .| .||||| ..  |.          
lesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl..........

vhlvvlyfvifqFEHKLIVAQLPqmeNESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGgyqYTGKMFINNRRADVSGDPKEYTIEVLPeg
            . .| |..| |   ... ||||| |....... .  . . . |...  . . .| |   . |........ .. .. . .|.|| .  
............ltrkfIatqgP...lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..

NSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQY
|. | ....... .| . . || .  .......  .  .   ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|... ||
ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy

ASIYAIVFDYIARKR
  .| ...... ||.
rflydallellkrkl
0040438 (Phosphotyrosine protein) phosphatases II 202-538 1.6e-54 180.7 In-house 2-310 (317) alignment 
Range on Protein: 202-538
Range on HMM: 2-310/317.0
WLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEAFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITltdvcrrmacvpayvhlvvly
.|... ||....|..  .  .| . .|.  ... .. ....|| .||     .|| .||.|.  .|..| .||||| ..                     
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvd.....................

fvIFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIC
  .... .| |..| |.   .. ||||| |.........  ... . |.. .   .  . |.... |.......  .. .. . .|.|| . |.|.|...
..gpnlkrkfIatqgPl...pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtv

QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
...|.  | .   || . ........  .  . ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|....||  .| ....
thfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalle

YIarKRGGKKAPVNKDINRFIDELAEISPACSPTKVMP
|.  ||.... |... ..... .|... .  .. |...
yl..krkltlepaselklkllklliplalddvklkeke
0043336 (Phosphotyrosine protein) phosphatases II 202-502 5.3e-49 162.5 In-house 4-277 (278) alignment 
Range on Protein: 202-502
Range on HMM: 4-277/278.0
WLGMPSALNFCNKNNDIQKIREEFGFLDSLVCNKTTEAFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITltdvcrrmacvpayvhlvvly
. ... ||. ...|.    ..| . .|.  ...... ....|| .||     .|| .||.|.  .|..| .||||| ..                     
vkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvd.....................

fvIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIC
   ... .| |..| |   ... ||||| |....... .  ..... |....   .    ||... |........ .. .| . .|.|| . |.. | ..
..gynvprkfiatqgP...lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtv

QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
...|. .| . . |. . ...........  . .|  |.| .  |.||.. ||.......||... .....|..| ...|||| |... ||  .| ....
thyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

YI
|.
yl
subfamily_Ptp69D_pd Subfamily Ptp69D 205-279 7.1e-07 23.6 In-house 9-85 (307) alignment 
Range on Protein: 205-279
Range on HMM: 9-85/307.0
MPSALNFCNKNNDIQKIReEFGFLDSLVCNKTTEAF--EANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVIT
...||.  ... |  ... |.  | .  ..|.|..   . |...||    | .|..||.|.. .|.|| .||||| | 
leealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik
0036941 (Phosphotyrosine protein) phosphatases II 209-506 2e-52 173.7 In-house 3-281 (297) alignment 
Range on Protein: 209-506
Range on HMM: 3-281/297.0
LNFCNKNNDIQKIREEFGFLDSLV--CNKTTEAFEANKVRNREGCPKIYDENRVQLnrpGHEDVNYINASVITltdvcrrmacvpayvhlvvlyfvIFQF
|.. .| ........||  |..|   ..... ....|. .||     .|| .||.|   ..|. .||||| ..                       ....
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvd.......................gydl

EHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADV--SGDPKEYTIEVLPEGNSDSVICQVH
..| |..| |.   .. ||||| |....... .  ..... | ...  . . .|.|.... |........ .|  ..| . .|.||.. ||..| .....
krkfIatqgPl...pntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthf

HHAPWKHLQQPPKTLPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLN---NGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIV
|.  | .   |. . .....|.....  .   ..  |.| .  |.||...||.| ....||.      ...|.|..| ...|||| |... ||  .| ..
hytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal

FDYIARKR
.... .|.
lellkkkl
0047943 (Phosphotyrosine protein) phosphatases II 210-502 1.6e-47 157.7 In-house 3-272 (273) alignment 
Range on Protein: 210-502
Range on HMM: 3-272/273.0
NFCNKNNDIQKIREEFGFLDSLV--CNKTTEAFEANKVRNREGCPKIYDENRVQLnrpGHEDVNYINASVITLTdvcrrmacvpayvhlvvlyfvifQFE
....| .......|||  | ||   ..... ....|| .||     .|| .|| |   |... .||||| ...                        ...
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgy.......................nlk

HKLIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGG-YQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHH
.| |..| |  ..   ||||| |.........  ..... | ...    . .|.|. ... ||....... .. .| . .|.|. . |...| .....|.
rkfiatqgPlpnt...vedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhy

APWKHLQQPPKTLPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 .|   . || . .....|..  .  .   .|  |.| .  |.||...|| ......||. . .....|..| ...||||.|... ||  .| ....|.
tgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 211-504 9e-47 155.7 In-house 19-306 (307) alignment 
Range on Protein: 211-504
Range on HMM: 19-306/307.0
FCNKNNDIQKIREEFGFLDSLVC----NKTTEAFEANKVRNREGCPKIYDENRVQLNRPGH--EDVNYINASVITLTDVCrrmacvpayvhlvvlYFVIF
. .. ........||  | |. .    . .. ....|| .||     .|| .||.|. ...  || .||||| ... ...               .. ..
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplll...............lldgy

QFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GNSDSVICQVH
 . .| |..| |.   .. ||||| |.........  . ... |..     .  ..|.... |........ .. .. . .|.|| .  |.. | .....
dlkrkfIatqgPl...petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

HHAPWKHLQQPPKTLPIIKMIHQFLS--EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIE---PNICEIMKNIKQQRPGGVESFAQYASIYAIV
|.  | . . || . .....|.. ..  |.  ..  |.| .  |.||...||.|.... ||... .   ... |..| ...||||.|... ||  .| ..
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

FDYIAR
.... .
lelllk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 211-503 1.7e-15 51.2 In-house 10-277 (515) alignment 
Range on Protein: 211-503
Range on HMM: 10-277/515.0
FCNKNNDIQKIREEFGFLDS-LVCNKTTEAFEANKVRNREGCPKIYDENRVQLN-RPGHEDVNYINASVITLTDvcrrmaCVPAYvhlvvlyfvifqfeh
| |||.    . |||  |    .  .|    | |  .|| .    || .||.|.      . .|.||| |   |      .  ||               
fvnknrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfd......ndkay...............

klIVAqlpQMENESFVEDFWYMIYQEQIHLVYlMVPDDKLKNT--TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNsDSVICQVHHHa
  | .   |. |.. |.||| ...||..  .  || . |  .    .  . |  |     |.. ..    .  ..    ...|| . .    . | | . 
..ias...qgPnkasvddfWrlvlqenvttia.mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhft.

PWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
 | .   |..|  ..|.|..  ....  .  . .  . | ||.  .| .   . . ...   .. ....||.|.||  |    ||| || .| ... 
eWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 214-278 1.6e-06 22.2 In-house 15-84 (290) alignment 
Range on Protein: 214-278
Range on HMM: 15-84/290.0
KNNDIQKIREEFGFLDSLVCNKTTE--AFEANKVRNREGCPKIYDENRVQLN-RPGHED--VNYINASVI
. .  .. |..|. |||   ..|..    . || .||     .||.||. |.  .||.|   .||||. |
hakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyi
0051299 (Phosphotyrosine protein) phosphatases II 215-502 1.7e-45 151.1 In-house 19-286 (288) alignment 
Range on Protein: 215-502
Range on HMM: 19-286/288.0
NNDIQKIREEFGFLDSLV--CNKTTEAFEANKVRNREGCPKIYDENRVQLNRPGH-EDVNYINASVITLTDVCrrmacvpayvhlvvlyfvifqfeHKLI
 |.. ...|||  | ||   .. .. ....|. .||      || .||.|. ..  |. .||||| |.. .                         .| |
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlk.......................rkfI

VAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAP
..| |    .. ||||| |.........  . . . |....   .  . ||... |........ .| .| . .|.|| .     |.. | .....|.  
atqgPl...pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytn

WKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
| . . |. . ......... .  . ..  |.| .  |.||.. || ......||... .....|..| ...|||| |... ||  .| ....|.
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 215-500 2.9e-13 44.4 In-house 5-264 (283) alignment 
Range on Protein: 215-500
Range on HMM: 5-264/283.0
NNDIQKIREEFGFLDSLVCNKTTEAFEANKVRNREGCPKIYDENRVQLNRPGHedvNYINASVITLtdvcrrmacvpayvhlvvlyFVIFQFEHKLIVAQ
.|. .  || .  |     . . .. . ||  ||.     .| .||.|.   .   .||||. |..                        . ..| |.||
vnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipv....................sksykqdkkyiiaq

LPQMENesfVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNR--RADVSGDPKEYTIEVLPEGNSDSVICqVHHHAPWKHLQ
 |  .    | ||| |...|.|  . .. .    ..   | .  ..|  .| |.. .  |   .  |   || .. |    .|  ...  .    | . .
sPldrt...vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy.Geftvtlrkettsnsfiikelllrvnssakstllla.hyqvidWleyg

QPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
. .    ..|.       .. ... . |    | ||.  ||.|  .....      .. ...|....||.. | .  ||  .. .|..
eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 215-505 4.1e-13 44.1 In-house 11-279 (281) alignment 
Range on Protein: 215-505
Range on HMM: 11-279/281.0
NNDIQKIREEFGFLDSLVCNKTTEAFE--ANKVRNREGCPKIYDENRVQLNRPGHEDvnyinasvitltdvcrrmacVPAYVHlvVLYFVIFQFEHKLIV
.|| .   ||.  | ..  ..|..| .  .|...||      ||  ||....  ..                        |.     .   .. |.. |.
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenk....................ntDYin..anfvpgykgekeyia

AQLPQMEneSfVEDFWYMIYQEQIHLVYLM---VPDDKLKntTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHApWK
.| |  .  | ...|| |......... ..   .  .|||      . |.|   .| |.. ... ..  .    | ....  |..    . |... | | 
tqgPvPa..s.lvafWqmvweqkvsaivmvtreieagklk..ChrYWPddnselky.gdvtvkstaeeekatyierkfkleresgetreveqlayta.WP

HLQQPPKTLPIIKMIHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARK
    | .|  ...  .. |. ..  ..| ...    | ||. ..|.   .......   | ............|   | . .||. .| .| |.. ..
dhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 218-511 5.8e-07 23.4 In-house 23-298 (305) alignment 
Range on Protein: 218-511
Range on HMM: 23-298/305.0
IQKIREEFGFLDSLVC-NKTTEAFEANKVRNregcpkIydenRVQLNRpgHEDVNYINASVITLTDVCrrmACvpAYVHLVVLYFVIFqFEHKLIVAQLP
..|.||||  |      . |  ||.||.  .      |     .  ||  ..||   . |.. | .      .   |.|   .   .   |...|.|| |
vdklreefrglakytrpdmtqvafnanqsad......i....aitknr..yqdvpcqdqsavkldkps...ps..dyihanyvgcpmi.pekrficaqgp

QmenESFVEDFWYMIYQEQIHLVYLM---VPDDKLKNTTTslFNDENGG-YQYTGKMFINNR-RADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKhl
    .  ...||.|. |...  . ..   |   ||| .    .   .|   .  . . ..|   .       |  | .|    | .    | |   |   
l...dqtidefwwmviqnkveqivmlcktvelgklkcaqy..wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhl.qwt..

QQPPKTLPIIKMIH-QFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN-NGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARKRGGK
. | . .|  |.   ..||  .  .  . |    | ||. . .   | ....  |   | . |..| ...||   ...  ||  |. ....|.  |   |
ewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykek

KA
 |
ya
subfamily_PTPN6_pd Subfamily PTPN6 219-506 1.9e-17 58.2 In-house 26-301 (306) alignment 
Range on Protein: 219-506
Range on HMM: 26-301/306.0
QKIREEFGFLDSLVCNKTTEAF----EANKVRNREGCPKIYDENRVQLNRPGHEDVNYINASVITlTDVCRRmacvpayvhlvvlyfvifqfEHKLIVAQ
. . |||  |.   ..|. .        || .||  .   .|..|| |..|.  . .||||..|. ..|                       ... | .|
agfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyik.kevkgs....................dksyiatq

lPQMenESFVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGD--PKEYTIEVLPEGNSDSVICQVHHHApWKHL
   .  |. |.||| |..||. ... ..  . .. |.  .  . ||.   . .||. ..| . .   |   .| ...   ....   . | |... |   
.gcl..ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks.WPdh

QQPPKTL---PIIKMIHQFLSEKQVQNAG-VCVVSLFGCGRACSFIGAL---YAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIAR
  | ..      .. ...  .| . ..|| ..|    | ||  .||        |..  . .. .| ...| ...|| | |   .||  .| ..  || .
gvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

KR
|.
kk
DSPc_SM00195 221-502 9.8e-54 177.8 In-house 2-262 (263) alignment 
Range on Protein: 221-502
Range on HMM: 2-262/263.0
IREEFGFLDSLV--CNKTTEAFEANKVRNREGCPKIYDENRVQLNRPG-HEDVNYINASVITLTdvcrrmacvpayvhlvvlyfvifQFEHKLIVAQLPQ
..|||  |..    ...|......|| .||    ..||..||.|...  .|. .||||..|...                       . ..| |..| |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.......................nkkkkyIatQgPl

menESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP
   .| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | 
...pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.| ......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....||. || .. .||
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 221-502 9.8e-54 177.8 In-house 2-262 (263) alignment 
Range on Protein: 221-502
Range on HMM: 2-262/263.0
IREEFGFLDSLV--CNKTTEAFEANKVRNREGCPKIYDENRVQLNRPG-HEDVNYINASVITLTdvcrrmacvpayvhlvvlyfvifQFEHKLIVAQLPQ
..|||  |..    ...|......|| .||    ..||..||.|...  .|. .||||..|...                       . ..| |..| |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.......................nkkkkyIatQgPl

menESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP
   .| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | 
...pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.| ......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....||. || .. .||
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 221-506 3.3e-48 159.9 In-house 2-278 (284) alignment 
Range on Protein: 221-506
Range on HMM: 2-278/284.0
IREEFGFLDSLVC----NKTTEAFEANKVRNREGCPKIYDENRVQLNRPGH--EDVNYINASVITLTDVCRRmacvpayvhlvvlyfvifQFEHKLIVAQ
..|||  | ||..    . .. ....|. .||     .|| .|| |.....  || .||||| ..  |.                      ...| |..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldlt..................yikkkfIatq

LPQMEnesFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQ
 |  .    ||||| |.........  . . .  ...  . .  ..|.... |........ .| .| . .|.|. ..| .. |......|. .| . . 
gPlpn...tvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgv

PPKTLPIIKMIHQFLSEKQ--VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI---EPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARKR
|| . ........  .  .   ..  ..| .  |.||.. || . ....||...    .....|..| ...|||| |....||  .| ....|. .|.
ppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0045098 (Phosphotyrosine protein) phosphatases II 225-504 4e-24 80.9 In-house 15-274 (278) alignment 
Range on Protein: 225-504
Range on HMM: 15-274/278.0
FGFLDSLVCNKTTEAFEANKVRNREGCPKIYDENRVQlnrpghedvNYINASVITLTdvcRRmacvpayvhlvvlyfvifqfehKLIVAQLPqmeNESFV
| .| . ..  |.  .. |. .||      || .||          .||||| |.     ..                      | |..| |    .| |
fllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy...pk......................kfIatqgP...lpstv

EDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAPWKHLQQPPKT--L
.||| |.....|. .  . .   |..     .  | ||... |......   .| .|    |..|        .  |   ...|  ||     |. .   
adfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

PIIKMIHQFLSEKQV-------------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEpnICEIMKNIKQQRPG-GVESFAQYASIYAIVFDYIAR
...... . ..  ..             ..  | |    |.||.. ...| . . .|..|.   . |. | ...||||  |... ||  .|  . ... |
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd..lleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN12_pd Subfamily PTPN12 232-505 2.4e-17 57.7 In-house 29-280 (290) alignment 
Range on Protein: 232-505
Range on HMM: 29-280/290.0
VCNKTTEAFEANKVRNREGCPKIYDENRVQLNRPGHED-VNYINASVITLTDVcrrmacvpayvhlvvlyfvifqfEHKLIVAQLPQMEnesFVEDFWYM
|.....   | |. .||      ||..||.|..  .|.  .||||..|  ..                        ... | || |  .    ..||| |
vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg.......................kleyiaaqgPLpk...tlddfWrm

IYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPkeYTIEVLPE--GNSDSVICQVHHHApWKHLQQPPKTLPIIKMIHQF
|.. ....| ..     |. .    .  |.|. .  .|.. ... . .   |   ..|  |     .   .. | |..| |   . | .. .....|...
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd..flirtLkveaqkesrkvyqfhYta.WPDhgvPssaksllelielv

LSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP---NICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARK
 . .. ..| ..|    |.||.   |   |. ..|.... |   .. ... ....||.  | .  ||  .|  | ... ..
relqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
0040439 (Phosphotyrosine protein) phosphatases II 234-503 1.1e-41 138.4 In-house 2-247 (249) alignment 
Range on Protein: 234-503
Range on HMM: 2-247/249.0
NKTTEAFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITLTDVCRRMacvpayvhlvvlyfvifqfehklIVAQLPQMEnesFVEDFWYMIY
....  ...|| .||     .|| .||.|.  ||... .|||||.|......||.                       |..| |  |    ||||| |..
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrf.......................iatqgPlpe...tvedfwrmlw

QEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQ
...|. .  . ... |.. .   . .. ||... |........ .|..| . .|.|. . ....|. ... .. .| . . || . .....|.. ..  .
elgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkale

V--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
   ..  |.| .  |.||.. ||.|.....||.   . .. |..| ...||||.|... ||  .| ...... 
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPRN_pd Subfamily PTPRN 235-500 8.4e-09 29.5 In-house 48-290 (297) alignment 
Range on Protein: 235-500
Range on HMM: 48-290/297.0
KTTEAFEANKVRNREGCPKIYDENRVQLNRP-GHEDVNYINASVITLTDvcRRMacvPAYvhlvvlyfvifqfehklIVAQLPQMeneSFVEDFWYMIYQ
|..   | |  .||.     ||..||.|..   .|. .|||||.|. .|   |.   |||                 | .| |     | | ||| |...
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhd..pra...pay.................iatqgpla...stvadfwqmvwe

EQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDP---KEYTIEVLPEgNSDSVICQVHhHAPWKHLQQPPKTLPIIKMIHQFLSE
. . ..  . . ..   . .. .  ..|   | .   ..     .  |    . . .  |   .    . | | .  |.. . |... .....  .    
qGvvvivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfh.flswpeegvPasaksllefrrkvnks

KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI-EPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
 . . . . | .  |.||.  .|     .|.|..|. | .|.  .. ...|||| |.. .|.  ... | .
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 236-503 2.1e-15 51.5 In-house 40-279 (287) alignment 
Range on Protein: 236-503
Range on HMM: 40-279/287.0
TTEAFEANKVRNREGCPKIYDENRVQLNrpghedvnyinasvitltdvcrrmACVPAYVHLVvlYFVIFQFEHKLIVAQLPQMENesfVEDFWYMIYQEQ
| .  . || .||     ..|..|| |.                         . | |.  |  .   .. ... |.|. | ..    . .|| .| ...
thniasqnkdknRltqilvpdnyrvllk........................gehpdyinav..fidgykekkafiiaesPmfnt...arnfWkliddrn

IHLVYLMVPDDKLKNTTTSLFNDENGGyQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFL-SEKQV
.. . ... .   ..     .  |.    . |.  |.    .|. .  | ..||  .. ..|    . .. . |.   . ..   |. .|..   .... 
vtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
 |. . |    . ||.  |. |  .||. ..    .. ...|. ..|.|| |   .||  |. ||  |. 
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 236-506 3.8e-10 34.3 In-house 36-275 (288) alignment 
Range on Protein: 236-506
Range on HMM: 36-275/288.0
TTEAFEANKVRNREGCPKIYDENRVQLNrpghEDV-NYINASVITltdvcrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQmenESFVEDFWYMIYQE
. ..| || .|.|       |  ||.|.    .|   ||.| |..                         .....|| || |    .. .| .| |. ..
iidsfianptrdryenlprcditrvkls....ddpdfyiaanvvs.......................sakykrrlicaqaPl...ngtieelWkmlles

QIHLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMF--INNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKHLQQPPKTLPIIKMIHQFlsek
... .  |    .| |. .   |  . |     |..   . ..|||.    |  .. .  ||.   .. ..| .  |..   | . |. ..... .    
dveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhll.eWdddgvPenylsplrllevl....

QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARKR
.  .  . | |  | ||.  .|  | |...|       | ..... ...|   ...  ||  .. .|..... |.
kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
0042113 (Phosphotyrosine protein) phosphatases II 237-502 2.1e-40 134.1 In-house 3-243 (245) alignment 
Range on Protein: 237-502
Range on HMM: 3-243/245.0
TEAFEANKVRNREGCPKIYDENRVQLNRPGHE-DVNYINASVITltdvcrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQ
. ....|| .||   . .|| .||.|. .|.. |..||||| ..                        ... .|.|..| |. |    ||||| |.....
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvd.......................gyritpkfiatqgPlpe...tvedfwrmlwelg

IHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTLPIIKMIHQFLSEkq
|. .  . ... |.  .   .  . |.....|........ .. .| . .|.|| ..|.. |  ....|. || . . |.     | ........|.|  
ittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..

VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 .|  |.| .  |.||.. ||.|.....||.   . .. |..| ...|||| |... ||  .| ......
dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 237-503 1e-22 75.8 In-house 50-291 (298) alignment 
Range on Protein: 237-503
Range on HMM: 50-291/298.0
TEAFEANKVRNREGCPKIYDENRVQLNR-PGHEDVNYINASVITltdvcrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQMENesfVEDFWYMIYQEQ
    ..|| .||      .|  || |..  . |. .||||| .                         .. ..  |..| | .|    ||||| |. .|.
varkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.......................aykgrnafiatqaPltet...vedFWrmvteed

IHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFL-SEKQVQ
|  . .. .   |..|. . .  ..|  .| |.. .. .. .. .|    ...|  . ....   .  |.  |   . | ..  .......   |..|  
igtiVmltnleeldktkyhkywPdegkety.geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqag

NAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
|. | |    | ||. .||     ......     . ...| ....||| |.. .||. || .| ....
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPRK_pd Subfamily PTPRK 237-500 2.7e-13 44.4 In-house 37-275 (314) alignment 
Range on Protein: 237-500
Range on HMM: 37-275/314.0
TEAFEANKVRNREGCPKIYDENRVQLNRPGHE-DVNYINASVItltdvcrrmacvpayvhlvvlyfVIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQ
.   . |. .|| |    ||  ||.|     . . .||||..|                         ..  .. ||.| |  |    |.||| ..|.|.
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.......................dsykrpaafivtqgPlqe...tvkdfWrlvyden

IHLVyLMVPD--DKLKNTTTSLFNDENGGYQYTGKMFINNrRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSeKQV
   . .|. .  .. .   .  . ..   |.    ....   ..     . ...| |  | ..  . .  ..  | . . | .   ..|....  . .| 
casi.vmltelvevgrvkClkyWPedtevygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkk.sqe

QNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
..||  ||  . |.||.  ||     .. ...    .. ...|.......  ||   ||  || ....
eeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN14_pd Subfamily PTPN14 237-505 1e-10 36.1 In-house 43-299 (300) alignment 
Range on Protein: 237-505
Range on HMM: 43-299/300.0
TEAFEANKVRNREGCPKIYDENRVQLNRPGHEDVNYINASVITLTdvcrrmacVPAYvhlvvlyfvifqfEHKLIVAQLPQmenESFVEDFWYMIYQEQI
| . . |. .||      |..|||.|.   ... .||||| |  .        | .              |.. |||| |.   |  |.||| |......
taklpenaeknrfkdvlPyednrvelsptkenstgyinassikvs........vggk.............ersyivaqgPl...eltvqdfWqmvWeqgv

HLVYLMVPD-DKLKNTTTSLFNDE--NGGYQYTGKMFINNRRADVS--GDPKEYTIEVLPEGNSDSVICQvhHHAPWKHLQQPPKTLPIIKMIHQFLSEK
.|. ..  . .. |. . . | ..  .      ||  . ..  . |     . .... || ..  .|.     .. |   . |.   . .. .... | .
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl..qytDWpdhgvPeDvkgflsyLeevqsvr

QV---------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARK
.          ..  | |  . | ||.   | .   |. |... | .| .... ...||   |...|||  .| ..  |. . 
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
0037934 (Phosphotyrosine protein) phosphatases II 239-501 8.8e-27 89.6 In-house 6-241 (243) alignment 
Range on Protein: 239-501
Range on HMM: 6-241/243.0
AFEANKVRNREGCPKIYDENRVQLnrpghEDVNYINASVITLTDvcrrmacvpayvhlvvlyfvifqfehKLIVAQLPQMEnesFVED----FWYMIYQE
 ...|. .||      || .|| |     |. .||||. |. |.                          .||. |.|  |    |||    || |....
llpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp..........................rliatqgPlpe...tveddlasfwrmlwel

QIHLVYLMVPDD-KLKNTTTSLFNdenGGYqYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKT---LPIIKMIHQFLS
.|. .  . ... . ..    ...   |.. . |......    . .| . .|... . . .  .   . .|. || . . |. .   | .......|..
gitvivmltelvElgrekcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefie

E-----KQVQNAGVCVVSLFGCGRACSFIGALYAINQLnngiEPNICEIMKNIKQQRPG-GVESFAQYASIYAIVFDY
|     .  ..  |.|    |.||.  .| |.. . .|    . .. |..| ...|||| .|... ||  .| ..  .
ellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 240-504 2.1e-15 52.7 In-house 43-282 (314) alignment 
Range on Protein: 240-504
Range on HMM: 43-282/314.0
FEANKVRNREGCPKIYDeNRVQLNRPGHEDVNYINASVITLTdvcrrmacvpayvhlvvlyfvifqfeHKLIVAQLPqmeNESFVEDF----------WY
...|. .||      .| |||.|.. ......||||| .                              | |..| |   .|  |.||          | 
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..........................lkfIatqgp...leitvvdfreepvlyyngwr

MIYQEQIHLVYLMVPDDK------------------------LkntttslfndenggyqytgkmfinN----------RradvsgdpkeytiEVLPEGNS
|. ...... ..    |.                                                 |          .             |.| ... 
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........................neptaadlellk.............eelydpel

DSVICQVHHHAPWKHlQQPPkTLPIIKMIHQFLSEKqVQNAGVCVVSLFGCGRACSFIGALYAINQLnnGIepNICEIMKNIKQQRP-----GGVESFAQ
 .     ... |.    ..| .| ... . .|. |   ..  | |    |.||...|. | | . .|  |.  .. |... ....||     | .|.. |
ferlgikylripvpD.gsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleealedvrlkRpinpnpgfieqleq

YASIYAIVFDYIAR
|  |. .. .|. .
yefilealleylkf
subfamily_PTPN3_pd Subfamily PTPN3 240-494 1.3e-09 32.4 In-house 40-267 (280) alignment 
Range on Protein: 240-494
Range on HMM: 40-267/280.0
FEANKVRNREGCPkiYDENRVQLNRpghEDVNYINASVITLTdvcrrmacVPAYvHLVvlyfvifqfeHKLIVAQLPQmenESFVEDFWYMIYQEQIHLV
 ...| | |. .|  ||. ||.|.    ....||||. . .         .|.  .||           . |..| |    .. ..|||.|.......|.
enlsknryrdilp..ydatrvklke...setdyinanyvnme........ipst.glv..........nryiatqGPl...aktatdfWqmvweqkssli

YLMVP-DDKLKNTTTSLFNDENGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHApWKHLQQPPKTLPIIKMIHQFLSEKQVQNAG
 ..    .. .      . ...   .|. .. .. .. | .       . .  .  . .  | |. . | |   . | ..  .......  . .....  
vmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla.WpdhgvPddsadflefvervrklrsgkeeP

VCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASI
| |    | ||.  .|    |.  ...  . .. .|......||   |.. .||  .
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv
Y_phosphatase Protein-tyrosine phosphatase 243-499 1.2e-54 180.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 243-499
Range on HMM: 1-234/235.0
NKVRNREGCPKIYDENRVQL-NRPGHEDvnYINASVItltdvcrrmacvpayvhlvvlyfVIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQIHLVYL
|| .||  .  .||..||.| ...|..|  ||||...                         .. ..|.|..| |    .|..|||| |..||.......
nkkknRykdilpydktrvklkgsegpsd..YInAnyv.......................kgykekkkfIatQgP...lkstiedFWrmvwqekvkvivm

MVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNA
.. ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | .. .....|... ..|. ...
ltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
 |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..||. .|....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 243-499 1.2e-54 180.6 In-house 1-234 (235) alignment 
Range on Protein: 243-499
Range on HMM: 1-234/235.0
NKVRNREGCPKIYDENRVQL-NRPGHEDvnYINASVItltdvcrrmacvpayvhlvvlyfVIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQIHLVYL
|| .||  .  .||..||.| ...|..|  ||||...                         .. ..|.|..| |    .|..|||| |..||.......
nkkknRykdilpydktrvklkgsegpsd..YInAnyv.......................kgykekkkfIatQgP...lkstiedFWrmvwqekvkvivm

MVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNA
.. ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | .. .....|... ..|. ...
ltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksg

GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
 |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..||. .|....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 243-498 6.1e-06 20.6 In-house 3-235 (237) alignment 
Range on Protein: 243-498
Range on HMM: 3-235/237.0
NKVRNREGCPKIYDENRVQLNRPGHEdVNYINASVITLTDvcrrmaCVPayvhlvvlyfvifqfeHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLM
||..|| |  . || .|| |. .| . ..||||. .   |        |                .| | || |    ||  .||| |..||.  .. ..
nkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfd......gtp................kkyiaaqgpl...esscddfwqmvwqekcsvivml

VP-DDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSV-ICQVHHHAPWKHLQQPPKTLPIIKMIHQFLSEK-QVQNAGVC
    .. .      . . .    | |.. .  .. .   |    .. .  ...   | . . .. . | .   | .|  .... .. . .   |...|  
tgliegnelkchkywpstdqpaay.gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpw

VVSL-FGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIV
..    | ||.  |.     . | ..    .| . ...|...||  ...  ||  |.  .
iihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 246-504 2.9e-14 48.5 In-house 4-173 (182) alignment 
Range on Protein: 246-504
Range on HMM: 4-173/182.0
RNREGCPKIYDENRvqlnrpgheDVNYINASVITltdvcrrmacvpayvhlvvlyfvIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQIHLVYLMVpd
.||      || .|         | .||||...                          .   . |..| | ..    |.||. |.....|...  .   
knrysdilpydhsr.........dldyInanlyl.......................gslpatrfiatqgplls...tvadflrmlkelgittivnlt..

dklkntttslfndengG----YqytgkM-FinnrradvsgdpkeytievlpegnsdSVICQVHHHAPWKHLQQPPkTLPIIKMIHQFLSekqvQNAGVCV
                .    .       .                                ... ||     |. .  ....|.. |.    ..  | |
................eelywp.....ell..........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlV

VSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIAR
    |.||......| . . .     . .. |..| ....|||.|..  ||  .. ...... .
HCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 259-505 1.8e-08 28.7 In-house 36-267 (270) alignment 
Range on Protein: 259-505
Range on HMM: 36-267/270.0
RVQLNRPGHE-DVNYINASVITltdvcrrmacvpayvhlvvlyfvIFQ-FEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVyLMVP--DDKLKNTTTS
||.|..  ..   .||||  .                         |.  ..| | |. |.   .. ...|| ||..|. . . .|.    .| ..    
RvrleeleedsataYinAnyvr.......................GfdgekkkYiaamgPl...pttlksfwrmiweekvtai.vmttgleEkgrkkCer

LFNDENGGYQYTGKMFINNRRADVSGDP--KEYTIEVLPEGNSDSVIcqVHHHAPWKHLQQPP------KTLPIIKMIHQF-LSEKQVQNA-GVCVVSLF
 .  |..    . ...|. .    . .       ...  .|..  ..   ...  |     |.      .|  ..||...   |||. ..|  . |    
YWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARK
| ||.  .|   .|.. |..  . .. .|.......|.  |.   ||. .|. |  |. |.
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0043147 (Phosphotyrosine protein) phosphatases II 272-495 1.9e-12 42.8 In-house 7-154 (172) alignment 
Range on Protein: 272-495
Range on HMM: 7-154/172.0
YINASVITLTDVCRRMACVPAYvhlvvlyfvifqfehklivaqlpqmeNESFVEDFWYMIYQEQIHLVYLMVPDdklkntttslfndenggyqytgkmfi
||||| . |. . .|  .  .                             . ..||| |.....|.... . .                           
yinasyldlyyipdrfiatqgp..........................lrntladfwrmlkelgithivnltel..........................

nnrradvsgdpkeytievLPEGNSDSVICQVHHHAPWKHLQQPpkTLPIIKMIHQFLSE--KQVQNAGVCVVSLFGCGRACSFIGALYAInqlnNGIepN
                  |  .   .     ... ||     |  .| ..  . .|. |   . ..  |.|    |.||.. .. |.. .     |.  .
..................lydpellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl..s

ICEIMKNIKQQRPGGVESFAQYASIY
. |... ....|||.|... ||  .|
leeavalvrekRpgavqnpsqyrfly
0051082 (Phosphotyrosine protein) phosphatases II 272-496 2.6e-08 29.1 In-house 5-147 (151) alignment 
Range on Protein: 272-496
Range on HMM: 5-147/151.0
YINASVITLTdvcrrmacvpayvhlvvlyfvifqfehkLIVAQLPqmenesfVEDFWYMIYQEQIHLVYLMVPDDKLKnTTTSLFNDENggyqytgkmfi
|||.| .|                              |.. . |        .||. ......|  .. . ...  . . ........           
yinfsyvtgg............................lyrsggp.......ladflellkelgiktivnlrseeerg.ycpeylpelg...........

nnrradvsgdpkeytievlpegnsdsvicQVHHHAPWKHLQQPPK---TLPIIKMIHQFLSekqVQNAGVCVVSLFGCGRACSFIGALYAINQlnngieP
                               ..| |.   . |.    .  ........|.    .|  | |    |.||   .....  . .       
.............................ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......v

NICEIMKNIKQQRPGGVESFAQYASIYA
.. |... ....||| | .. |.  .. 
sleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 278-503 1.1e-14 49.1 In-house 63-284 (290) alignment 
Range on Protein: 278-503
Range on HMM: 63-284/290.0
ITLTDVCRRMACVPAYVHLVvlYFVIFQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRAD
||| ..  .  |   |.. .  |   .. ... |..| | ..    . ||| .|.||..  . ...   . ....   .  ...  .  |.. |.     
itLrpisghkDCtneyinAc..yikgykekkqyiatqgpvsn...tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllnee

VSGDPKEYTIEVLPEGN--SDSVICQvHHHAPWKHLQQPPKTLPIIKMIHQFLS-EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIM
.  .  | ..||  . .  . . . | ..   |..  . ...  |. .|..    ...  |  . |    . ||.  |. |  .||. .     .. ...
tlneyierklevknknsagakqsvtq.yqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvl

KNIKQQRPGGVESFAQYASIYAIVFDYIA
|. ..|.|| |..  ||  |. ||. |. 
ksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 286-502 1.1e-07 25.7 In-house 69-279 (439) alignment 
Range on Protein: 286-502
Range on HMM: 69-279/439.0
RMACVPaYVHLVVLYFVIFQFEHKLIVA-QLPQMENesfVEDFWYMIYQEQ-IHLVYLMVPDDKLKntttslFNDENGGyQYTGKMFInnrRADVSGDPK
 .  || . | .   ..   .. || .| | |. |.   ..||| ...... ...| |    .  |      .   ..   . | . .   |.|   .  
eipgvp.hshyinanyikGyyddklyiatqgpkket...tddfwrlviekktvtivmltnlvesyk......ywpsdae.vcygdiav...rvdrnielp

EYTIEV---LP---EGNSDSVICQVHHHApWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVS-LFGCGRACSFIGALYAINQLNNGIEPNICEIMKN
.|.|     .     .. .  . |.|. | | . . | ..  ......   | .. .. |  ||    | ||. . |    |..||.   . .|  |.| 
nyvirgfkvfnerdttekertvlqfhyia.wpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkv

IKQQRPGGVESFAQYASIYAIVFDYI
...||   |....||  ||  |.. |
lrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 291-503 8.7e-14 45.8 In-house 69-280 (303) alignment 
Range on Protein: 291-503
Range on HMM: 69-280/303.0
PAYVHLVvlyFVIFQFEHKLIVAQLPQMENESfveDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVL
 .|.|     .. .. ..| |..|||     .   ||| || ..... | |.. | . ..        .|  .    . .|           . ... ||
ssyihas...yleldsskkailtqlplshtaa...dfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvl

PEGNSDS-VICQVHHHAPWKHLQQPPK-TLPIIKMIHQFLSE--KQVQNAGVCVVSLFGCGRACSFigALYAINQLNNGIEPNICEIMKNIKQQRPGG--
   | |   . .|||.  | | . | . .  ..| | |  |   |  ..     .|| ||||| .|  ||.   .|    | .  ...| ... | |   
svsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtf..alfetahlslhseqasldlvkclenvrngrlh

-VESFAQYASIYAIVFDYIA
 |. ..|.. .|... ... 
avqnlsqfsvvytllaehvl
0044763 (Phosphotyrosine protein) phosphatases II 298-496 2.5e-09 32.5 In-house 27-165 (178) alignment 
Range on Protein: 298-496
Range on HMM: 27-165/178.0
VlyfvifqfeHKLIVAQLPQmenesfvEDFWYMIYQEQIHLVYLMVPDDKLK--NTTTSLFNDENggyqytgkmfinnrradvsgdpkeytievlpegns
.         . |....||.       .|.. ..... |...  . ... |   ..    . ...                                   
l.........pglylgslpp.......addlellkelgithivnlteelelgflkcdpywpeeag...................................

dsvicQVHHHAPWKHLQQPPkTLPIIKMIHQFLSEKQ-VQNAGVCVVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPgGVESFAQYASI
       ..| |.     |.  | ..  ...|. | .  ..  | |    | ||..... | . . .       .. |... ....|| .|... |.  .
.....iqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqL

YA
| 
ye
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 300-502 2.9e-06 21.5 In-house 74-277 (307) alignment 
Range on Protein: 300-502
Range on HMM: 74-277/307.0
YFVIFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPD---DKLKNTT-TSLFNDENGGYQYTGK-MFINNRRADVsGDPKEYTIEVLPEGN
|. |    .|.|.|| |.   |. . .|| |. ||..  | ...      |.|      | . ..  .  ... . ..|  |.    | |  |.|     
ylgiaikpkkficaqgpl...entqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakk.lapdedlinvttlkv

SDSVICQVHHHAPWKHlqQPPKTLPIIKMIH-QFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP-NICEIMKNIKQQRPGGVESFAQYA
  .  ..  .|  |.    | .  | |..    .|.  . ..  | |    | ||. . ..  .  ... .||.  .. ........||.  ... ||| 
dwaqksrtiqhlqwen..wpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl

SIYAIVFDYI
 .. ....| 
ylhrvlleyf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 302-501 5.6e-10 33.2 In-house 82-235 (392) alignment 
Range on Protein: 302-501
Range on HMM: 82-235/392.0
VIFQFEHKLIVAQLPqmeNESFVEDFWYMIYQEQIHLVyLMVPddKLKNTTtslfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQ
  |. |.  | .| |   | . ..||| |..||..  .  ||   |||.                                          |...  ..|
psfdnekayiasqgp...naaslddfwrmvfqenvtti.amvt..klkegd.......................................kgddartvaq

VhHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
  | . |   . | .|  ..|.|..  ..       . .    | ||.   |     . . ..    .. ... ||...||  |..  ||| ||. |.. 
f.hftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 303-500 3e-14 48.2 In-house 63-253 (284) alignment 
Range on Protein: 303-500
Range on HMM: 63-253/284.0
IFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIE---VLPEGNS
 .| ..| | .| |.   .  ..||| ||.. ..  . |.               ...    .  |. |.. | .|      . .||..    .  .|. 
GyqrkdkyiatqGPl...dntladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgke

-DSVICQVHHHAPWKHLQQPPKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYA
 |    . .|   | .  .|  . ........   |..|. ..| . |    |.||.  .|     ......    .. .......|||.  |....|| 
kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

SIYAIVFD
 ||. . .
fiysalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 303-500 4e-14 47.7 In-house 99-289 (319) alignment 
Range on Protein: 303-500
Range on HMM: 99-289/319.0
IFQFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIEV---LPEGNS
 .| . | | || |.   .  ..||| ||.. ..  . |.                .     .  |. |.. | .|      . .||..       .|. 
GyqrkdkyiaaqGPl...dntladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgke

-DSVICQVHHHAPWKHLQQPPKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYA
 |    . .|   | .  .|  . ........   | .|. ..| . |    |.||.  .|     ......    .. .......|||.  |....|| 
kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

SIYAIVFD
 ||. . .
fiysalle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 304-505 1.4e-57 189.4 In-house 86-288 (302) alignment 
Range on Protein: 304-505
Range on HMM: 86-288/302.0
FQFEHKLIVAQLPQMENESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPK-EYTIEVLPEGNSDSVICQV
 ......|.||||... |. ||.|| |..||.|  |...| ...||.|   ||  . | |.. ||||.|||. . . . | .|.||||||| |.||...|
PeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanv

HHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 ..  ||. . | |   .|| ...   .|.  .. . .||  |.||| .|. .  |...|..| |||| ||.|.|..|||  |.|. ||.|.| ..  ||
yvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

ARK
 .|
kkk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 304-503 3.9e-15 50.8 In-house 85-284 (305) alignment 
Range on Protein: 304-503
Range on HMM: 85-284/305.0
FQFEHKLIVAQLPqMENesFVEDFWYMIYQEQIHL-VYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLP-EGNSDSVICQ
.. ..| |||| | ..|   |.|||..|..|...  | |    .  |.     . .. .  .  |.. .. .      |  |  ...   .....|    
ykrkkkyivaqgP.lkn..tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvl

VHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQ-NAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
 ..   |     | ..  ....|..   ... . .  . |.   | ||.  ||    |...|..  . .. |..|.....|.. |.. .|| ... .. .
qyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde

YIA
.| 
lit
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 304-503 3.3e-13 44.4 In-house 87-284 (319) alignment 
Range on Protein: 304-503
Range on HMM: 87-284/319.0
FQFEHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVP-DDKLKNTTTSLFNDENggYQYTGKMFINNRRADVSGDPKEYTIEVlpEGNSDSV---I
.| ..| | .| |    |  .|||| |...|... | ..    .|||     ....||  ..  |.. ..    .   |     ...  . .|. |    
yqerekfiatqaPl...entiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl..nkkssevetRe

CQVHHHAPWKHLQQPPKTLPIIKMIHQFLSE-KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIV
 . ...  |   . | |.. .......     .. |.  . |    | ||  .||    .......    .. ....... ||.  |.  .||  || ..
vkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeal

FDYIA
 ... 
leave
subfamily_PTPRG_pd Subfamily PTPRG 304-505 2.5e-11 37.5 In-house 87-290 (563) alignment 
Range on Protein: 304-505
Range on HMM: 87-290/563.0
FQFEHKLIVAQLPQMEnesFVEDFWYMIYQEQIHLVyLMVPD--DKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLP----EGNS--
.| ... |..| |  .    ..||| ||.... ...  |...  .. ..     .     . .  |.. ..  . .|   . . |. .      ....  
yqkskafiatqgplkd...tfddFWrmiWeqnvaii.vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcd

DSVICQVHHHAPWKHLQQPPKTLPIIKMIHQFlSEKQVQNAG-VCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASI
.    . .| . |   . | ..|| ......  |  . ..|| . |    | ||.  .|     ..|...    |. ...| |. ||.  |..  ||  .
teklvrqyhytkWPdhgvPehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYifl

YAIVFDYIARK
. .. . || |
hdalleaiask
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 304-502 1e-06 23.0 In-house 68-259 (267) alignment 
Range on Protein: 304-502
Range on HMM: 68-259/267.0
FQFEHKLIVAQlPQMENEsfVEDFWYMIYQEQIHLVYLMVPDdkLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIcQVH
.. ....|| |   ..|   . ||. .| ....  . |. .    ..    ..  . |  .    . ..        | .  |.|.  . .|   .  ..
yktknafivtq.dplknt..itdfltvihdqkvpvivlltkv..ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnv.tly

HHAPWKhlqQPPKTLPIIKMIHQFLSEKQVQNAGVCVV--SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
..  |.      .  | .| .   |...|..|..  .|     | ||. .|. .   .... .    .| . ...|..||.| |..  .|  |. .. .|
yykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

I
 
a
subfamily_PTPRA_pd Subfamily PTPRA 305-502 4.9e-15 50.2 In-house 98-295 (330) alignment 
Range on Protein: 305-502
Range on HMM: 98-295/330.0
QFEHKLIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTG-KMFINNRRADVSGDPKEYTIEVLPEGN---SDSVIC
.  .| | || |. |    ||||| ||.. . . . ..   .. |..    .  ..| . |   .. ...    |.   ... .. ||..    .  .. 
kekdkfiaaqGPkeet...vedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvr

QVHHHApWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
|.| .. | ..  | ..  ..|....  . .|..   . |    | ||. .||     .....     .. |..|....|||  | .  ||  || .. .
qfhfts.wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

YI
| 
yy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 305-503 3.3e-14 47.7 In-house 89-285 (297) alignment 
Range on Protein: 305-503
Range on HMM: 89-285/297.0
QFEHKLIVAQLPqmeNESFVEDFWYMIYQEQIHLVyLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVH
 ..|.||  | |   ... |.||| |...||.  . .|. ||. ..     .  ..|  .  |.. .     .      . ..||  .   .  |. | .
gnkhrlittqmP...mkatvadfWamvldeqvsti.vmlnddnerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyq

HH-APWKHLQQPPKTLPIIKMIHQFLSEKQVQNA-GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
.   | |  ..  ..  ..|.|..   . . ..   . |  | | ||.  ..  .  . . ..  | .| ...| ..|.||  |    ||. .| .| ..
fveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea

IA
. 
ll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 305-500 1.3e-11 39.0 In-house 89-277 (315) alignment 
Range on Protein: 305-500
Range on HMM: 89-277/315.0
QFEHKLIVAQLPQMeneSFVEDFWYMIYQEQIH-LVYLMVPDDKLKNTTTSLFNDENGGYqytGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIcQVh
. ... | || |..   . |.||| ....|.|  .| |    .. |. .   . |..  |   ||. .  .  .|  .    |. |  . |   |. |. 
nkkrryiaaqgpnv...asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy...Gkitvtrkseevnteytvrtlsvvfgdnirevv.ql.

HHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
|.. |   . |  |.|....| .    .. . . . |    | ||. .||     ..|..     .. .......|.| . |.. .||  || ....
hytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPRB_pd Subfamily PTPRB 305-505 4.2e-10 34.1 In-house 91-288 (293) alignment 
Range on Protein: 305-505
Range on HMM: 91-288/293.0
QFEHKLIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYqYTGKMFINNRRADVSGDPKEYTIEVLPeGNSDSVICQvH
. ... |..| |  |    |.||| |..... . . ..    .| |      . ...    . |.. ..    ..  |    ....   ...   . | .
nsprefiatqGPlpet...vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek.ekeerkvrq.y

HHAPWKHLQQPPKTLPIIKMIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
|.  |     | || ......... ...  . ... . |    | ||.  ||     ......    .|. |. .....|   | . .||  |.  | |.
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

IARK
. .|
lrkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 306-502 1.2e-14 49.0 In-house 88-279 (288) alignment 
Range on Protein: 306-502
Range on HMM: 88-279/288.0
FEHKLIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDENGgYQYTGKMFINNRRADVSGDPKEYTIEVLpEGNSDSVICQVHh
 ..| | .| | ..    |.||| ..|..... .  .    .. |..    . |..   .  |.. .  .     .|  . ....    ...  | | . 
kkkkyiatqgPladt...vndfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrkllle.kkkteleitqyq.

HAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.  |   . |  . |......|    .| .   . |.   | ||.  || .  .|.....    ...........||.  |.   ||  || .. . |
ylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Ptp69D_pd Subfamily Ptp69D 307-504 2.3e-18 61.4 In-house 90-288 (307) alignment 
Range on Protein: 307-504
Range on HMM: 90-288/307.0
EHKLIVAQLPQmenESFVEDFWYMIYQEQIHLVyLMVPDDKLKNT--TTSLFNDEnGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG------NSDSV
..| |.|| |    |. ..||| || . ...|.  |. . . ||       . .|    ||  .. ..  . .  .|  . ...|   .      .    
kkkfiaaqdPv...eatigDfWRmiaeqevtli.vmlsnlteknrkkcakYWpie.devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrk

ICQvHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIV
. | .|.  ||  . |  .  ..|.|.|  . .. ... . |    | ||.  |.     ..||..  . .|.|..|....||.  |.|..||  .|  .
vvq.yhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

FDYIAR
 ||.  
ldyssy
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 307-503 4.7e-17 57.0 In-house 51-243 (250) alignment 
Range on Protein: 307-503
Range on HMM: 51-243/250.0
EHKLIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHA
..  |..| |  .    .|||| |...|..  . ..      ..| .  .   ..  .| |.. ..    .. .| .  .. .  . ..|..| .  |. 
rkafiatqgPlqat...iedfWrmvleeksgtivmLtnLkesektyhqywP.vekaeky.Gdvtvsllskeefadytkrklklskakkaderivrqlhfv

PWKHLQQPPKTLPIIKMIHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
 |     | ..  .......  ...|  .|| | |    | ||. .||     ...|..    .. ...| ....||. ||| .|| ..| |.  .. 
vWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
0051429 (Phosphotyrosine protein) phosphatases II 307-504 4.1e-09 32.0 In-house 21-227 (272) alignment 
Range on Protein: 307-504
Range on HMM: 21-227/272.0
EHKLIVAQLPQMENesfVEDFWYMiYQEQIHLVYLMVPDDKLKNTTTSL-----------FNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GN
...|. .. |   .   ..|||.. ....|. .  . ... ..   ...           ..|.       |.... .    .  |   .....  . ..
pgrlyrsggplplt...aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

SDSVICQVHHHAPWKHLQQPPKTlpIIKMIHQFLSekqvqNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPN--------ICEIMKNIKQQRPGGVE
...    . |.  |     |...  ........|.     .  | |    |..|   .. .|. . ...     .        . |... ...|||| |.
gearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavq

SFAQYASIYAIVFDYIAR
. .||. .| .. ... .
teeqylflyeallellrs
subfamily_PTPN13_pd Subfamily PTPN13 307-500 7.7e-09 30.2 In-house 76-267 (273) alignment 
Range on Protein: 307-500
Range on HMM: 76-267/273.0
EHKLIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLF--NDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHH
|.. |..| |  |    |.||| |... . ... ..  .   ..     .  . .|   . .... ... .     . .  ...|     ..|   .  .
eyeyiacqGPlPet...vkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahln

HAPWKHLQQPPKTLPIIKMIHQFLSEKQvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
 . |   . | ......... .  . .. ... . |    | ||. ..|    ... ...  | .. ||......|| | | .  ||  .| .. .
fvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
0036282 (Phosphotyrosine protein) phosphatases II 308-495 1.2e-10 36.8 In-house 17-163 (174) alignment 
Range on Protein: 308-495
Range on HMM: 17-163/174.0
HKLIVAQLPQMenesfvedFWYMIYQEQIHLVYLMVPDDKLK---------NtttslfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSV
 .||. | |          ||.|.....|. |  . .   |.                                                     .. . 
prliagqgpla........fwemlkelgittvvmlleekelglykcinywpe.........................................lredler

ICQVHHHAPWKHLQQPP--KTLPIIKMIHQFLSEkqVQNAGVCVVSLFGCGRACSFIGALYAINQLNngiePN---ICEIMKNIKQQRPGGVESFAQYAS
    ... ||   . |.  . | ..| ....|||   ..  | |    |.||.  ...|.. . .|     ..   ...... ...||||.|... ||  
lgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrf

IY
.|
ly
subfamily_CG7180_pd Subfamily CG7180 309-502 8.8e-16 52.4 In-house 86-290 (296) alignment 
Range on Protein: 309-502
Range on HMM: 86-290/296.0
KLIVAQLPQmenESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSlFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPE----------GNSDSV
. || . |.   .. |..|| ..|.|.|. |  .      ..   | .  ...  || |..|..  . .   . | .|. .  .           . .  
eyivteapk...ketvdefWrlvydeeisavvvLtktfdfakmyps.ywpnkskeqy.geifveiveekqyanlkirtfkltkkivalteqekqvkaetR

ICQVHHHAPWKHLQQPPKT----LPIIKMIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYA
|... .   |.  .. |      . ........  .   . ... |.|||  | .|.  ....  .......  | .. | .| ....||. ||.  .| 
ivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYk

SIYAIVFDYI
 || .. ...
yiYdvlleav
subfamily_PTPN23_pd Subfamily PTPN23 309-503 2e-14 48.1 In-house 84-281 (288) alignment 
Range on Protein: 309-503
Range on HMM: 84-281/288.0
KLIVAQLPQmenESFVEDFWYMIYQEQIHLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVhHHA
..|..| |.   .| . ||| |.|...  ..  |. .... |. . . .  ..|  .  |.. .  ..   ..   |.....  ....    .. . .  
dfiatqaPl...qstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshl.qlt

PWKHLQQ---PPKTLPIIKMIHQ-FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN--NGIePNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
 | .|     | . | ... ... . ....  .. . |  . | ||.  |     |...|.  ||. ..| .... ...||   |.  .|.   | .|  
sWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngl.ldiiqvvsrlreqRrfmvqekeqlkfsyeavle

YIA
.. 
aar
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 309-535 1.8e-12 42.0 In-house 90-310 (318) alignment 
Range on Protein: 309-535
Range on HMM: 90-310/318.0
KLIVAQLPQMENesfVEDFWYMIYQEQ-IHLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAP
. | || |  |    .|||| |... .   .| |    .. |.     .  ..|  .| ||. .. .    ..|    ...|  .....| . . .|.. 
ayiaaqaPlpet...ieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhyts

WKHLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARkr
|     | ..  ..... |  . .| ..||. ||    | ||.  ||     ......    .. ...|....||.  |    ||  || .. ...|   
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas..

gGKKAPVNKDINRFIDELAEISPACSPTK
 |..    .|... | || | .|    |.
.gdtevdasdlrsrirelreqdpesgtte
subfamily_egg_pd Subfamily egg 309-526 6.3e-10 33.2 In-house 84-293 (307) alignment 
Range on Protein: 309-526
Range on HMM: 84-293/307.0
KLIVAQLPqMENEsfVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPKeYTIEVLP-EGNSDSVICQVHHHA
..|.|| | . |   |.||| |..||... . ..    . ..      . |.   ..  | . |.| . |   ||  ...  |   |  |      |   
efilaqap.lknt..vddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadpl.frvtklklvGgddeerflehwqg

PWKHLQQPPKTLPIIKMIHQflsekqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNG--IEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIaR
 .... .    | ..... .           | | .  |. .|.... .  |. .|  |      . . .. ....|.  |||  .|  .| .|  .. |
dvnnssdvysplrvlrklrn.......lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff.r

KRGGKKAPVNKDINRFIDELAE
   |    .. | .|...| .|
dvigsakeldvdyerwleerse
subfamily_PTPRD_pd Subfamily PTPRD 310-531 2.2e-14 48.0 In-house 93-307 (564) alignment 
Range on Protein: 310-531
Range on HMM: 93-307/564.0
LIVAQLPQMENesfVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWK
 | .| |  |    .|||| |....... . ..      ...  . .  |.|  .| |.. ..        |    |...  . .|.|   .  |.  | 
yIAtqgPlaet...iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWP

HLQQPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIARkrGGK
.  .| .. .....|..  . .. ..  . |    | ||   ||   . ......    .| ...|....||.  |..  ||. |. .. ...|   | .
dhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac..gnt

KAPVnKDINRFIDELAEISPAC
. .. ..... ...|||...  
eves.enlkqhlqkLaeveedt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 316-503 8.5e-15 49.4 In-house 92-278 (315) alignment 
Range on Protein: 316-503
Range on HMM: 92-278/315.0
PQMENESFVEDFWYMIYQEQIHLVYlMVPDDKL--KNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIeVLPEGNSDSVICQVHHHApWKHLQQ
 |. ... |.||| |..||..  .  || . .   |      . |...     |.. ..    .  .|     . |. ....   . | . .  | .   
sqgPlkasvddfwrmvlqekvttiv.mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqfte.wPdkGv

PPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
. .|  ..|.|..  .... ..  . |  . | ||.  .| .   ..|....   .. ...||....||  | .  .|| || .| ... 
dkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 316-503 1.5e-10 35.7 In-house 96-289 (325) alignment 
Range on Protein: 316-503
Range on HMM: 96-289/325.0
PQMENESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWK--HLQQ
 |. . . ..|.| .... .  .| ..   |. |.  .  . .| |  .  | . .. | ..   |     ..|    . ..   .  ..  |.    |.
aqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqk

PPKTLPIIKMIHQFLSEKQV----QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIA
 | ||  |  . . .||.        . . |    | ||.  ||    |.... .  . .| . .|.....||  ||.  ||  ||  . ... 
rpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 318-501 6.3e-06 20.0 In-house 101-282 (290) alignment 
Range on Protein: 318-501
Range on HMM: 101-282/290.0
MENESFVEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYQYTGKMFINNRRA-DVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP
   .. | |.| |. ||..  . ..    .. |      . ...|     |.. .      |   . .  |. |    .  . . . ..   |     . 
GalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksval

KTLPIIKMIHQFlsekQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
 || ......      .  .  | |    | ||. .|.    ... | .| | .. .... ... | . |.   ||  .  |..|.
stlallrtlril....rkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 322-504 5.1e-15 50.3 In-house 84-270 (274) alignment 
Range on Protein: 322-504
Range on HMM: 84-270/274.0
SFVEDFWYMIYQEQIHLVyLMVPDDKLKNT-TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPKTLP
. |.||| |||||..... .|. . | .|    . .  .. .|. ...    . . .   . ..|... |   .. .   .. . .. |   ..| .. .
ntvadfWrmiyqeevqvi.vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddant

IIKMIHQFLS---EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIAR
.......  .   |.. . | | |    | ||.  ||... |..||.. |  .. .|. |....| | |..  ||  |. ..  |  |
lldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
0046846 (Phosphotyrosine protein) phosphatases II 322-498 1.3e-11 40.1 In-house 34-169 (176) alignment 
Range on Protein: 322-498
Range on HMM: 34-169/176.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKtlPII
. ..||. |.....|..|  .  .  |.      . .|  ....                                     ..| ||   . |.    ..
rtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl..ell

KMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnnGIEPNICEIMKNIKQQRP-GGVESFAQYASIYAIV
  . .|. | . ..  | |    |.||.. .. |.  .     .   .. |... ...||| | |....||  .|  .
lellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 323-502 3.8e-11 37.5 In-house 87-270 (285) alignment 
Range on Protein: 323-502
Range on HMM: 87-270/285.0
FVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEN-GGYQYTGKMFIN---NRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPK-T
 . |||.|||||.|  | ...   .      .|.  |. |     ||  |     .   ..|   .    .  |  |   .   | . ||   |  |. .
tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapeda

LPIIKMiHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 |.|.. .... . . ..  .||    | ||...|.|  ||  .. .  . .. .|.....  |   |.|. |.  .| ....|.
rpmiel.ykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0049260 (Phosphotyrosine protein) phosphatases II 323-495 6.5e-11 37.6 In-house 21-143 (152) alignment 
Range on Protein: 323-495
Range on HMM: 21-143/152.0
FVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNdenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKTLPIIK
 ..||| |... .|. .  .  .. |.   .                                                 ..| ||     |. .  .. 
tladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllf

MIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAInqlnngIEPNICEIMKNIKQQRPGGVESFAQYASIY
...     .. ..  | |    |.||.  .. |.. .         .. |... ....|||.|... |.  .|
lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 353-492 4.2e-06 20.5 In-house 178-330 (347) alignment 
Range on Protein: 353-492
Range on HMM: 178-330/347.0
TSLFNDENGGYQYTGKMFINNRRADVSGDPK----EYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTLPIIKMIHQFLSEK----QVQNAGVCVV
.|.|  |   |      .|| |. .|    |     ||.||. || |.. ...|.  . |   . |    | | ...   .  |        . | | |.
ssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvm

SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVES--FAQYA
  .|  |... . .   |.|. .|  |.  ...|....|| |      |  ||
cdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytya
0048179 (Phosphotyrosine protein) phosphatases II 389-495 2.7e-08 29.2 In-house 36-138 (144) alignment 
Range on Protein: 389-495
Range on HMM: 36-138/144.0
VLPEGNSDSVICQ--VHHHAPWKHLQQPPKTLPIIKmIHQFLSEK-QvQNAGVCVVSLFGCGRACSFIGALYAInqlNNGiePNICEIMKNIKQQRPGGV
. .|   ......   ..| ||   . |. .  ... . .|. |  . ..  | |    |.||..... |   .    .|   .. |... ....|||.|
lteeyepefleregiqylhlpwpDhgvpdllellle.flefieeale.eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpgav

ESFAQYASIY
... |.  ..
pnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 393-498 3e-08 29.0 In-house 40-139 (145) alignment 
Range on Protein: 393-498
Range on HMM: 40-139/145.0
GNSDSVICQVHHHAPWKHLQQPPKTlPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnngIEPNICEIMKNIKQQRPGGVESFAQYA
 .  .     ... ||   . |. .  ..  . .|. | . ..  | |    |.||......|   .         .. |... ...||||.|... |. 
lellerlgiqylylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlr

SIYAIV
 .|  .
flyefe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 393-506 7.9e-06 19.8 In-house 180-291 (305) alignment 
Range on Protein: 393-506
Range on HMM: 180-291/305.0
GNSDSVICQ-VHHHAPWKHLQQPPKTLPIIKMihqfLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP-NICEIMKNIKQQRPGGVESFAQ
|   ..     .|   |     |.  | |...    | . ..    . |    | ||. | .   | ..|| .|    .   |.. |..||   ... ||
gpgekarkvthyhwidwpdrgvpaadlailel....lekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaq

YASIYAIVFDYIARKR
|  .. ....|. .|.
ylfvhqvilnyfrkkk
PTPc_DSPc_SM00012 401-498 2.9e-19 64.6 In-house 3-103 (105) alignment 
Range on Protein: 401-498
Range on HMM: 3-103/105.0
QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQ--NAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQYASIYAI
.. |.  |.. . | .. .|....... ..|. .  .. |.|..  |.||.. |. . ....||...  |..|..|.| ...|||| |....||  .|..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

V
.
l