Gene H06I04.5 in Caenorhabditis elegans

Synonym: CELE_H06I04.5, H06I04.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP109_AA protein Get Run
CeleP109_AA_761-1050 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
WSN Domain of unknown function 1-58 4.1e-23 71.1 Pfam-A 10-67 (69) alignment
Range on Protein: 1-58
Range on HMM: 10-67/69.0
MQSLARLTNGISLEIGLIDGSIPSDDAIAELLHMGPVKLQELISMDTDAASKAITDLG
....||.||||.|. |||.||||.||.|||||..|...|..|...|.| ... ...| 
lsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls

RhoGEF RhoGEF domain 142-253 8.2e-06 12.2 Pfam-A 65-176 (180) alignment
Range on Protein: 142-253
Range on HMM: 65-176/180.0
QKGDTIDSITANFPRlYRDFN-KTENYAISFENVLSSLKLLDSIKN-MSLFLEPVYQeSAFRKELNLSTLTSVIYQALNQFSEQLQTIRKYVSNTKASES
.. .....|.  |    ..|    ..|   |...|. || | . .. .. ||. . . |   ..|.|..| ..  | | ..   |. . |. ..... ..
kekkdaqkigdvflk.leeflkvYseYisnfdkalkllkelskknskfkkflkeaee.spesskldLeslLikPvqRlprYplLLkellkatpeshpdye

DLKYIQRLINSLNS
.|. ..  |....|
alekaleaikevas

0051299 (Phosphotyrosine protein) phosphatases II 758-1046 2.8e-49 163.5 In-house 8-283 (288) alignment
Range on Protein: 758-1046
Range on HMM: 8-283/288.0
DHSVKAIQYQMKENKTLLQEWLKSVYRALRTiGETSVTNYDDNISERRHSMYICEPSTMAVLEG----FKNPFINANVMMF--GKIEWIMAQGPMDgtek
.. .|.... .. ..|.|.|  . ... | . ...|....  |..  |.| ...  ..  .|        . .|||. . .   | ..|..|||..    
eellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp....

kkdetdkpkrSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYR-KNKGEQKKT
          .|.|..| .. ..|| . | |...|| . .||| |...  ||.| . ... .......       ..|.|..|.|.||..  .......|
..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrt

VDILLYSAWPEHGAPQEAYPALEILKFCETY----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
| .. | .||.||.|. . . |..|... ..    .. |.|||| |||||||..|. . ... .|...  . ...  .|..|.|.||   |  ..  .. 
vthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall





0045450 (Phosphotyrosine protein) phosphatases II 759-1047 3e-50 167.0 In-house 13-302 (307) alignment
Range on Protein: 759-1047
Range on HMM: 13-302/307.0
HSVKAIQYQMKENKTLLQEWLKSVYRALRT-IGETSVTNYDDNISERRHSMYICEPSTMAVLEG-----FKNPFINANVMMF----------GKIEWIMA
..............|.|... .....   . .||.|....  |.. .|.. ... ..|  .|         . .|||. ...           | ..|..
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrk
|||...              |.|..| .. ...| . | |...|| ...||| |..|. |..| ..|.  .......       ....|..|.|.|..  
qgPlpe..............tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......ldgytvrtlevtdl..

NKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKV---TQIIDIILPVRQCRHGAVQ
.. ..  || .. | .||.||.|.   ..|.... ...       .. |||||| |||||||..|. . ...  | ..     . ...  .|..|.||||
dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq

DDTQVTYILLCVTK
   |  ..  .. .
npeqyrflyealle

0043336 (Phosphotyrosine protein) phosphatases II 761-1045 1.3e-45 151.4 In-house 8-273 (278) alignment
Range on Protein: 761-1045
Range on HMM: 8-273/278.0
VKAIQYQMKENKTLLQEWLKSVYRALRtiGETSVTNYDDNISERRHSMYICEPSTMAVLEGFK----NPFINANVMMFG--KIEWIMAQGPMDGtekkkd
.||... .. .||||..  .....     ...|.... .|.. .|.. ... .... .|. ..    . .|||. . .   . ..|..|||...      
lkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......

etdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSdkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNyrkNKGEQKKTVDIL
        |.|..| .. ...| . | |...|| . .||| |..   ||.|.. ... .......       ..|.|..| |.||   ..  ...|| ..
........tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn...lgdgesrtvthy

LYSAWPEHGAPQEAYPALEILKFCET----YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
 | .||.||.|    . |..||.  .     .. |||||| |||||||..|. . ...  | .   . ...  .|..|.|||| . |  ..  ..
hylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

0040438 (Phosphotyrosine protein) phosphatases II 762-1062 1.3e-53 177.7 In-house 7-289 (317) alignment
Range on Protein: 762-1062
Range on HMM: 7-289/317.0
KAIQYQMKENKTLLQEWLKSVYRALRTigETSVTNYDDNISERRHSMYICEPSTMAVLEGFK----NPFINANVMMFG--KIEWIMAQGPMdgtekkkde
.|... .| ..|.|.|. . ...      ..||... .|.. .|.. ... ...  .|  ..    . .|||. . .   | ..|..|||.         
lalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.........

tdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILL
      .|.|..| .. ...| . | |. ..| ...||| |...  |..| . ... .......       ....||.|.|....   ..... || .. 
.....pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl...gdsesrtvthfh

YSAWPEHGAPQEAYPALEILKFCETY----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
| .||.||.|.   . |..|......    .. |||||| |||||||..|. . .... |..   . ...  .|..|.||||   |  ..  .. . |. 
ytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

KMPVPYLRSFD
|.. ... .. 
kltlepaselk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 764-1063 1.1e-170 560.8 In-house 1-302 (302) alignment
Range on Protein: 764-1063
Range on HMM: 1-302/302.0
IQYQMKENKTLLQEWLKSVYRALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFGKIEWIMAQGPMDGTEKKKDETDK---PK
|....|.|||||.|.|..|.|||........||....|||||.|..||||.|||.|..|||.||||||.....|.||||||||||||||.....|   ||
igadrklnktlleefleyveraleklkkktstnlekdiserrkslficepktmaklvdfkndfinanvlkldeikwimaqGpmdGtekkekvskkpivpk

RSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLAEFTDKKDFTLYTVEITNYRKNKgEQKKTVDILLYSAWP
.||.|||||||||.||||.||||.|||.|.||||.||||||||.|.|..|..||...||||.||||||.|.||||||.|..|.| ..|||||||..||||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafsawp

EHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKMPVPYLRS
.||||.|||.||.||||||.||||||||||.|||||||||||||||.||.|||||....|.|||||||.|||||..|..|.|||||||||||..|.||||
dhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekagvlylrs

FDA
|||
fda

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 770-1041 1.4e-29 98.3 In-house 19-275 (305) alignment
Range on Protein: 770-1041
Range on HMM: 19-275/305.0
ENKTLLQEWLKSVYRAlRTIGETSVTNYDDnISERRHSMYICEPSTMAVLEGFKNP---FINANVMM--FGKIEWIMAQGPMdgtekkkdetdkpkRSTC
.... |..  ||.|.   .  .   .. .   ..| ... . ... . . |  ...   .|||. .    .| ..|.||||.              ..| 
ysdkgleaqykslyee.eesidvgkkeank.aknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPl..............kntv

EKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKtidiktdLAEFTDKKDFTLYTVEITNYRKnkGEQKKTVDILLYSAWPEHGA
.  | || .  |   |.|.. |||...||  |. .... . .| ..|..       | ...  .|..   ..|.. ..   ....||  .    ||.|| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsve.......lksektasdyieRklkisiede..dkesrtvlqyqltdWPdhGv

PQEAYPALEILKFCE-TYKKN----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
||.|   |...|  . ..||.    .|||||.||||||. .|..  .. . | .| .. ...  .|. | ..||   | ...
pqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl

0050432 (Phosphotyrosine protein) phosphatases II 771-1051 3.8e-53 176.2 In-house 40-301 (308) alignment
Range on Protein: 771-1051
Range on HMM: 40-301/308.0
NKTLLQEWLKSVYRALRtIGETSVTNYDDNISERRHSMYICEPSTMAVLeGFKNPFINANVMMFG----KIEWIMAQGPMdgtekkkdetdkpkRSTCEK
...||.|. . ...    ..|.||..  .|..  |.. ...  ..  .| . .. .|||. ...     . ..|..|||.               .|.|.
dlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPl..............pntved

HWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVG-GVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYRKNkgeQKKTVDILLYSAWPEHGAP
.| .. ..|| . | |. .|| . .||| |. ...| |.|.. ...........       ..|.|..|.|.||....   . .|| .. | .||.||.|
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdg...esrtvthfhytnWpdhgvP

QEAYPALEILKFCETY--KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
... . |..|......  .....|||| |||||||..|. . ...  |..   . ...  .|..|.|.||.  |  ..  .. . |. 
pspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0039614 (Phosphotyrosine protein) phosphatases II 771-1053 3.6e-47 156.6 In-house 30-293 (297) alignment
Range on Protein: 771-1053
Range on HMM: 30-293/297.0
NKTLLQEWLKSVYRALRtigETSVTNYDDNISERRHSMYICEPSTMAVLEGFKN-----PFINANVMMFGKI---EWIMAQGPMDGtekkkdetdkpkrs
.||||... .....      ..|...   |.. .|.. ... .... .| ....      .|||. . . ..   ..|..|||...              
sktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe..............

TCEKHWALIEQHNVAICVQLCGFVEGEDkKCASYYSDKVGgvlRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNyrknkGEQKKTVDILLYSAWPEH
|.|..| .. ...| . | |. .|| .  |||.|.....|   .. ... .......       ....|..| |.||     ... .||  ..|  ||.|
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn.....ngesrtvthfqytgwpdh

GAPQEAYPALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKM
|.|. .   ||.|.....       .. |||||| |||||||..|. . .... |..   . ...  .|..|.|||| . |  ..  .. . |. |.
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0036941 (Phosphotyrosine protein) phosphatases II 773-1060 3.3e-56 186.1 In-house 13-288 (297) alignment
Range on Protein: 773-1060
Range on HMM: 13-288/297.0
TLLQEWLKSVYRALRtIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFGK--IEWIMAQGPMDgtekkkdetdkpkrSTCEKHWAL
.||... ..... |  .|..||... .|..  |.. ... ..|. .|.. .. .|||. . . .   ..|..|||..              .|.|..| .
alllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp..............ntvedFWrm

IEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDlaeftDKKDFTLYTVEITNYrknKGEQKKTVDILLYSAWPEHGAPQEAYP
. ..|| . | |. .|| . .|||.|.....|..| . ............     ...|.||.|.|.|..   ......|| .. |  ||.||.|. ...
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespas

ALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCL---KKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKMPVPYLRS
 |........       .. |||||| ||||.||..|. . ...     | .   | .... .|..|.||||   |  ..  .. . |. |.....|..
lldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk

0047943 (Phosphotyrosine protein) phosphatases II 773-1046 5.6e-50 165.7 In-house 13-269 (273) alignment
Range on Protein: 773-1046
Range on HMM: 13-269/273.0
TLLQEWLKSvyRALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMF--GKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWAL
.||.|. .   . | .....||... .|..  |.. ...  ... .|.. .. .|||. . .   | ..|..|||.               .|.|..| .
llleefell..lslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl..............pntvedfwrm

IEQHNVAICVQLCGFVEGEDKKCASYYSDKVGG-VLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYRKNKgeqKKTVDILLYSAWPEHGAPQEAY
. ..|| . | |. .|| . .||| |.....|. .|.. ... ......|       |.|.|..|.|.||.  ..   ..|| ...|  ||.||.|.   
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtge...srtvthfhytgwpdhgvppsle

PALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
. ||.......       .. |.|||| |||||||..|. . .|.  |..   . ...  .|..|.|.||   |  ..  .. 
sllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

0046845 (Phosphotyrosine protein) phosphatases II 774-1052 8.5e-49 161.8 In-house 2-277 (284) alignment
Range on Protein: 774-1052
Range on HMM: 2-277/284.0
LLQEWLKSVYRALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKN-----PFINANVMMFG-------KIEWIMAQGPMDGtekkkdetdkpkr
| .|. . .      . ..||...  |.|  |.. ...  ..  .|  ...      .|||. . .        | ..|..|||...             
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.............

sTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrkNKGEQKKTVDILLYSAWPE
 |.|..| .. ..|| . | |...|| . .||| |.... |.||.. ... .......       |.|.|..|.|.||.  . ... .|| .. | .||.
.tvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnl..gytgesrtvthfhytswpd

HGAPQEAYPALEILKFCETY------KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKK---VTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
||.|... . ||.|......      .. ..|||| |||||||..|. . ...  |..   .  . ...  .|..|.|.||   |  ..  ..   |. |
hgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk





subfamily_PTPN3_pd Subfamily PTPN3 781-1051 4.8e-25 83.0 In-house 23-277 (280) alignment
Range on Protein: 781-1051
Range on HMM: 23-277/280.0
SVYRALRTIgETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFgkiewimaQGPMDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICV
 .||  . . ..|...  .|.|  |.   .   .|   |.  .. .|||| . .        . |  |. ..   |  | ..|... | .. .... . |
qlyrkkpgl.aisaarkpenlsknryrdilpydatrvklkesetdyinanyvnm........eipstglvnryiatqGPlaktatdfWqmvweqkssliv

QLCGFVEGEDKKCASYYSDkVGGVLRFRNYSLKTIDIktdlaefTDKKDFTLYTVEITNyrKNKGeQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET
 |   ||   .||  |. .  .  |.. ..|.|             .| . |  . ...  |..  .....  | | |||.|| |...   ||...  ..
mlttlverGrvkChqyWPe.tedeleygefsvkceke.......detksyvlrelvlkd..ketk.eerkilqlqylaWpdhgvPddsadflefvervrk

YK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
..    . |.|||| |.|||| |....  . |  ...   ..||.  .|. |   ||  .| ...  .. |  .|
lrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 782-1051 2.4e-25 84.2 In-house 20-278 (281) alignment
Range on Protein: 782-1051
Range on HMM: 20-278/281.0
VYRALRTIG--ETSVTN-YDDNISERRHSMYICEPSTMAVL----EGFKNPFINANVMM--FGKIEWIMAQGPMdgtekkkdetdkPkrSTCEKHWALIE
 |..|. ||  .|..    |.|. . |.|  .    |  ..    |  .. .|||| .    |. |.| .|||.            |  ..... | .. 
eyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPv............P..aslvafWqmvw

QHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlrfrnySLKTIDIKTDLAEFTDKKDFTLYTVEItnyrKNKGEQKKTVDILLYSAWPEHGAPQEAYPAL
...| . | .   .|..  ||  |. |.          .||  |..    . ..|. .   ....    .... ....|  | | |||.||.|...   |
eqkvsaivmvtreieagklkChrYWPddns........elkygdvtvkstaeeekatyierkfkl....eresgetreveqlaytaWPdhGvPattkell

EILKFC----ETYK-KNVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
|  |      |. .   ...||| ||||||| .|.   .. . .. . ... ...  .|. |   ||  .| ... . | . |..
efrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_PTPN13_pd Subfamily PTPN13 784-1041 4e-24 80.3 In-house 21-261 (273) alignment
Range on Protein: 784-1041
Range on HMM: 21-261/273.0
RALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGfKNPFINANVMmfgKIEWimaqgpmDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLC
| |... ...|.. ..| .. |.   .    |   |.. . ..|||. .   |..        .  | .   .  |   |..  | .. . .. . . . 
relkpldtcevgkkkenkdknryrnvlPydetrvklgd.eggyinasli...kvpv.......gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

GFVEGEDKKCASYYSDKVGGVLRFRNyslktiDIKTDLAEFTDKKDFTLYTVEITNyrkNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK
  .|..  ||  |. .. .  |  .|       .. .| . .....|.. ......   .. .. . |  | . .||.|| |..| . |....   . ..
lekekgkvkchrywPesknkklkvsn......rlevellkvqkldgfvvralavkd...sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

---NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
    ..|||| |.||.|||..|.  ..|  ..|  .. .|.  .|. |.| || . |  ..
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv

0045098 (Phosphotyrosine protein) phosphatases II 785-1050 2.1e-44 147.4 In-house 18-273 (278) alignment
Range on Protein: 785-1050
Range on HMM: 18-273/278.0
ALRTIGETSVTNYDDNISERRHSMYICEPSTMAVlegfknPFINANVMMFGKIEWIMAQGPMDgtekkkdetdkpkrSTCEKHWALIEQHNVAICVQLCG
.|  ..| .. .| .|..  | . ... .... .       .|||. ... . ..|..|||..              ||....| .. .... . | |..
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlp..............stvadfwrmlwelgitvivmlte

FVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTDlaeftDKKDFTLYTVEITNYRKNKGEqKKTVDILLYSAWPEHGAPQEA--YPALEILKFCET--
.||.. .||| |. .  ||.|.. ...........      |.   . ..|. ...... .| . .| .| |  ||.||.| .    . ||.|.|..   
lvelgrekcaqywpe..ggsltygdftvtllseevl.....ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefireal

---------------YKKNVLVHCSEGVGRTGTLVAIKYGIDLClkKKVTQIIDIILPVRQCRHG-AVQDDTQVTYILLCVTKGLM
                .. |||||| ||||||||||. . ..|.  ...  . ...  .|..|.| |||   |  ..  .. . |.
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

DSPc_SM00195 789-1047 3.2e-46 153.2 In-house 16-260 (263) alignment
Range on Protein: 789-1047
Range on HMM: 16-260/263.0
IgETSVTNYDDNISERRHSMYICEPSTMAVLEGF----KNPFINANVMMF--GKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQL
  ||. .. . | |  |......  .|   |.      .. .||||.. .   | ..|..|||.               ||.|..| .. ...| | | |
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl..............pstvedFWrmvweekvkiivml

CGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLaeftdkKDFTLYTVEITNYRKnkgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK
. ..| . .||..|. .. ||  .| ..|.|... ...       ....|.|.|.|.  |   |....|  . | .||.||.|... . ||.|..... |
teeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksk

K----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.     ..|||| |||||||.|.|.. .. . ..|  .| .|.  .|. |.|.|| ..| ..|  .. .
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 789-1047 3.2e-46 153.2 In-house 16-260 (263) alignment
Range on Protein: 789-1047
Range on HMM: 16-260/263.0
IgETSVTNYDDNISERRHSMYICEPSTMAVLEGF----KNPFINANVMMF--GKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQL
  ||. .. . | |  |......  .|   |.      .. .||||.. .   | ..|..|||.               ||.|..| .. ...| | | |
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl..............pstvedFWrmvweekvkiivml

CGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLaeftdkKDFTLYTVEITNYRKnkgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK
. ..| . .||..|. .. ||  .| ..|.|... ...       ....|.|.|.|.  |   |....|  . | .||.||.|... . ||.|..... |
teeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksk

K----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.     ..|||| |||||||.|.|.. .. . ..|  .| .|.  .|. |.|.|| ..| ..|  .. .
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

subfamily_Ptp69D_pd Subfamily Ptp69D 790-1041 3e-22 74.1 In-house 38-278 (307) alignment
Range on Protein: 790-1041
Range on HMM: 38-278/307.0
GETSVTNYDDNISERRHSMYIC---EPSTMAVLEGFK-NPFINANVMM-F-GKIEWIMAQGPMDgtekkkdetdkpkrSTCEKHWALIEQHNVAICVQLC
 .|.|.. ..|    |.   .    .   .....| .   .|||. .  .  | ..|.||.|..              .| .  | .| . .| . | | 
kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve..............atigDfWRmiaeqevtlivmls

GFVEGEDKKCASYYSDKvgGVLRFRnyslktiDIKTDLAEFTDKKDFTLYTVEITNYRKNKGEQKKTVDILL--YSAWPEHGAPQEAYPALEILKFC-ET
   | ..|||| |...      ..        ||  .|...  ..|..  ......  .. || ...  ..   | .|..  .|. |   |....   | 
nlteknrkkcakYWpie..devqyg.......dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

YKKN---VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
||.|   ..|||| ||||.|..||..  .. . . .  .|....  .|. |   ||   | ...
yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl

0040439 (Phosphotyrosine protein) phosphatases II 791-1047 7.9e-45 148.8 In-house 2-244 (249) alignment
Range on Protein: 791-1047
Range on HMM: 2-244/249.0
ETSVTNYDDNISERRHSMYICEPSTMAVLEG----FKNPFINANVMMF--GKIEWIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCG
|.||...  |.. .|.. ... .... .|.     | . .|||... .   | ..|..|||...              |.|..| .. .... . | |. 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..............tvedfwrmlwelgitvivmLts

FVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET----
.|| . .||| |...  ||.| . ... .......       |.|.|..|.|.||.   .  .. ||  . |  ||.||.|.   ..|.... ...    
lvelgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkalee

--YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
   .. |||||| |||||||..|. . ...  |..   . ...  .|..|.|||| . |  ... .. .
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 791-1040 6.2e-28 92.3 In-house 47-274 (290) alignment
Range on Protein: 791-1040
Range on HMM: 47-274/290.0
ETSVTNYDDNISERRHSMYICEPSTMAVL-EGFKNPFINANVMMFGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGE
| .. . . ..   |.   .|.  |  .| .|..  .. || .   |  .|..||..              ..|    | .. |..||  | ||  .|  
erkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGal..............kdtvidiwrmvlqekvaaivmlceliedG

DKKCASYYSDKVGGVLRFRNYSLKTiDIKTDLAEFTDKKdftlyTveITNYRKNKGEQKKtVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHC
  ||. || .| | || | ....     ..|  . . ||     |  ..   |..| ..| .  |   .||..  .. .   | .|.   .    | |||
kakceqyypekeGevltfGeitvlc.seeddkdaniikk.....t..lsvrdkdsGkehk.lkhlkikswpdksvalstlallrtlrilrkasGpvvvhc

SEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTY
| |.|||||.|||. |... |. |  ...|..  .|..| ..|| |.|   
saGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 791-1047 3.1e-24 80.7 In-house 47-288 (298) alignment
Range on Protein: 791-1047
Range on HMM: 47-288/298.0
ETSVTNYDDNISERRHSMYICEPSTMAVLEG----FKNPFINANVMMfgkiewimaqgPMDGTEkKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFV
|..|.....| .  |.. .|   |.  |||      .  .|||  .             ..|..     | .|  .| |  | .. .....  | |   .
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh...........aykgrn.afiatqaPltetvedFWrmvteedigtiVmltnle

EGEDKKCASYYSDKvggvlRFRNYSLKTIdiktDLAEFTDKKDFTLYTVEITnyrKNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK---
| .  |.  |. |.     . ..|   |.    .| .  .. |..  .....   |.| |....|  | .. ||..|.|..|   |..|.  .....   
eldktkyhkywPde.....gketygeitv....sllskeefadlivrklkvs...kkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqag

--NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
   |.|.||.||||.|| .||.  ..   |..|  . ...  .|. | ||||  .| ..|   | .
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 792-1053 5.4e-25 83.0 In-house 35-275 (288) alignment
Range on Protein: 792-1053
Range on HMM: 35-275/288.0
TSVTNYDDNISERR-HSMYICEpSTMAVLEGFKNPFINANVMMfgkiewimaqgpmD-GTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGE
 ..... .| .. | . .. |.  |   |.   . .|.|||.                  ...   .. | ..| |. | .. . .|   | || ..|  
diidsfianptrdryenlprcd.itrvklsddpdfyiaanvvs.............sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekG

DKKCASYYSDKVGGVLRFRNYslktidiktdlAEFT-DKKDFTLYTVEITNYRKNK-GEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLV
 .| | |.  |.|   |.. .              . .|..    .|...  | .| ||.|. | || .  |...| |..  . | .|.  ....| ..|
keksaeyfPsklGekarigrl...........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivv

HCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKM
|.|.||||||||. |   ..    .    |  ..   |. |  |.|   |  |.  || . |. | 
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk

0042113 (Phosphotyrosine protein) phosphatases II 793-1045 5.9e-41 135.9 In-house 2-239 (245) alignment
Range on Protein: 793-1045
Range on HMM: 2-239/245.0
SVTNYDDNISERRHSMYICEPSTMAVLEGFK----NPFINANVMMFGKI--EWIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFV
||...  |.. .| | ... ..|. .|   .    ...|||. . . .|   .|..|||...              |.|..| .. .... . | |. ..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..............tvedfwrmlwelgittivmLteee

EGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET-----Y
| . .||| |...  |..|.. ... .......       ..|.|..|.|.||    .  ....|  ..|  ||.||.|      |..|.|...      
elgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
.. |||||| |||||||..|. . ...  | .   . ...  .|..|.|||| . |  ..  ..
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 793-1044 7.4e-26 85.7 In-house 28-265 (285) alignment
Range on Protein: 793-1044
Range on HMM: 28-265/285.0
SVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVM-MFGKI--EWIMaqgpmdgtekkkdeTDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGE
. | |. |    |..   |   |  ||. .   .| |. | | ||    .|               |. |   |    | .| | ..|  . || ..|| 
tytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyit..............tqgplpetlsdfwhmiyqekiayvlmlctlfegg

DKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLAEFTdkkdfTLYTVEITNYRKNKGEQKKtVDILLYSAWPEHGAPQEAYPALEILKFCET---YKKNVL
 .||| || .|.| |..| .| .   . | .    |      | .. ..|      |    .. .    ||.. ||..| | .|. |. .     .| . 
vekcalyypeklgevvkfgkyeitlteckeeaiagt.....ilnaltvintedasseply.mnhvqvpwwpdqlapedarpmielykwvkkvnpkekpic

VHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLC
|||| ||||| |.| | |     ...   ...||.  .|  |  |||   |. .. . 
vhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvv

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 794-1041 2.1e-13 44.8 In-house 27-258 (283) alignment
Range on Protein: 794-1041
Range on HMM: 27-258/283.0
VTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFgkiewimaqGPMDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKC
..  |.|    |.   .     .  |.   . .|||  ..             .  .||   .  | . |    | .. .....  | |  . |....||
iasadenkrknrnqeivpadqwrvelksesrdyinavfipv.........sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

ASYYSDKvgGVLRFRNYslkTIDIKTDlaefTDKKDFTLYTVEITNYrknkGEQKKTVDILLY--SAWPEHGaPQEAYPAL---EILKFC--ETYKKNVL
. |.  .  |   . ..   |. .. .    | .. |.   . . .     .  |.|. .  |    | | | .|    .|   . ..    |  |  ..
sqyWPkr..GsedyGef...tvtlrke....ttsnsfiikelllrvn....ssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPiv

VHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
||||.|.|||....|.   ..  | . |  .  ..  .|. | .|||   |   .
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv

0037934 (Phosphotyrosine protein) phosphatases II 795-1045 1.4e-38 128.2 In-house 5-238 (243) alignment
Range on Protein: 795-1045
Range on HMM: 5-238/243.0
TNYDDNISERRHSMYICEPSTMAVLEGfkNPFINANVMMFGKiEWIMAQGPMDGTEKKkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCA
 ..  |.|..|.| ... . .. .|||  . .|||| ..  .  .|  |||...| .           . ...| .. .... . | |. .|| . .|||
allpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.rliatqgPlpetved..........dlasfwrmlwelgitvivmltelvElgrekca

SYYSdkvGGVlRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNyrKNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETY------------K
 |..   |.| .. ... .......       ..|.|..|....|  .. ......|  ..| .||.||.|..  . |..|... ..            .
qywp...gev.tygdftvtllseeh.......lddytvrtlllen..ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg

KNVLVHCSEGVGRTGTLVAIKYGIDLClkkKvTQIIDIILPVRQCRHG-AVQDDTQVTYILLCV
. |||||| ||||||||.|. . ..|.   .   . ...  .|..|.| |||   |  ..  ..
gpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeal

Y_phosphatase Protein-tyrosine phosphatase 800-1046 2.9e-51 169.5 Pfam-A 1-234 (235) alignment
Range on Protein: 800-1046
Range on HMM: 1-234/235.0
NISERRHSMYICEPSTMAVLEGFK--NPFINANVM--MFGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCAS
| . .|......  .|.  |.| .  . .||||..     | ..|..|||.               ||.|..|... |..| . |.|.  .| ...||| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPl..............kstiedFWrmvwqekvkvivmltsleekgrekcaq

YYSDKVGGVLRFRNYSLKTIdiktdLAEFTDKKDFTLYTVEITNYRKNKgeQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSE
|.... .. |.. ......        | .|.|..||...|...  ...  .|..|  | | .||.||.|... . |.... .|..|    ..|.||||.
Ywpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsa

GVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
|||||||.||... .. . ... ... .|.  .|..|.|.||. .|  ..  ...
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 800-1046 2.9e-51 169.5 In-house 1-234 (235) alignment
Range on Protein: 800-1046
Range on HMM: 1-234/235.0
NISERRHSMYICEPSTMAVLEGFK--NPFINANVM--MFGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCAS
| . .|......  .|.  |.| .  . .||||..     | ..|..|||.               ||.|..|... |..| . |.|.  .| ...||| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPl..............kstiedFWrmvwqekvkvivmltsleekgrekcaq

YYSDKVGGVLRFRNYSLKTIdiktdLAEFTDKKDFTLYTVEITNYRKNKgeQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSE
|.... .. |.. ......        | .|.|..||...|...  ...  .|..|  | | .||.||.|... . |.... .|..|    ..|.||||.
Ywpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsa

GVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
|||||||.||... .. . ... ... .|.  .|..|.|.||. .|  ..  ...
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 800-1053 1.3e-25 85.5 In-house 1-175 (182) alignment
Range on Protein: 800-1053
Range on HMM: 1-175/182.0
NISERRHSMYICEPSTMavlegfKNPFINANVMMFGKIE--WIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCgfvegedkkCASYY
|.. .|.| ... . ..       . .||||.....     .|..|||...              |..... .. .... . | |.         .  |.
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls..............tvadflrmlkelgittivnlt.........eelyw

SDKVggvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqKKTVDILLYSAWPEHGAPQeAYPALEILKFCETYKKNVLVHCSEGVGRTG
 ...                                              ....  .||  || ||.|   . .|.... ..  ...|||||| ||||||
pell..............................................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtg

TLVAIKygidLCLKKKvTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKM
||||.     |..|..   . ...  ||..|.|.|.   |  .. |..   |. |.
tlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_egg_pd Subfamily egg 805-1034 2.7e-07 24.6 In-house 45-255 (307) alignment
Range on Protein: 805-1034
Range on HMM: 45-255/307.0
RHSMYICEPSTMAVLE----GFKNPFINANVMMFGKI--EWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGedKKCASYYS
|  .  |. |.   ||     . . || || .  . .  |.|.|| |.              . | .  | .. | .|   | |   .|   ..|  |. 
rskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqapl..............kntvddfwrmvfqeevqyivmltsrkes..erceyywp

DKVGGVLRFRNYSLKTIDIKTDlaeftDKKDfTLYTveITNYRKnKGEQKKTVDiLLYSAWpEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGT
      |..   ||.   .| |     .| |  |..  .|. .   | ...    | .  . .     . |  |..|.      | |.|.. .|| ...|
kaesdslvtvpGslrienlkvd.....skad.plfr..vtklkl.vGgddeerf.lehwqg.dvnnssdvysplrvlrklrnlskpvvvqdilGvskaat

LVAIKYGIDLCLKKKVTQ--IIDIILPVRQCRHGAVQD
||||.  .   |.  .|.  .   .  .|. |. .|. 
lvaieiallsllrGpitkslvlravvflrlrrrlsves

subfamily_PTPRK_pd Subfamily PTPRK 813-1043 3.1e-19 63.9 In-house 60-271 (314) alignment
Range on Protein: 813-1043
Range on HMM: 60-271/314.0
PSTMAVLEGFKNPFINANVMmfgkiewimaqgpmDGTEKKKD--ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVggvlrfRNY
.  ... .  .. .|||...              |. .. .    | .|...| .  | |. ..| |  | |  .||    ||  |. ..       . |
vflitidgdpssdyinaali..............dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt......evy

SlktiDIKTDLAEFTDKKDFTLYTVEITNYRKNKgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGI
     |||  | | . ....   .  ...  ... |....|  . . .||.|. |..|   |....  .. ..    ...|||| | ||||| .||.  .
g....dikvelvetellaelvvrifrveklargq.eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

DLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
|.  ...|  .  ..  .|. .   |.   | ..|  
dmieregvvdvfnavktlrsrkvnmveteeqykfiyd

subfamily_PTPN1_pd Subfamily PTPN1 819-1049 5.6e-19 62.9 In-house 51-271 (290) alignment
Range on Protein: 819-1049
Range on HMM: 51-271/290.0
LEGFKNPFINANVMMFGKI--EWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlrFRNYSLKTID
||  .| .|||... . ..  ..|..|||.               .|..  | .. ...    | |  .|| |  |||.|.  .       ..  |. . 
leradndyinaslveleeakrsyiltqGPl..............pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee....ekellledtk

IKTDLAEFTDKKDFTLYTVEITNyrkNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCL
.| .| .  .|. .|. ..|..|    | .. ...    | .||. | |.     |. |  .         .  ...||| |.||.||.. .   . |  
lkvkliseerksyytvrllelen...lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvlie

KKKV---TQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGL
||.     .| . .| .|. |.| .|   |. .  | . .| 
kkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 822-1078 7.9e-25 82.6 In-house 44-269 (290) alignment
Range on Protein: 822-1078
Range on HMM: 44-269/290.0
FKNPFINANVMMF-GKIEWIMAQGPMDGTekkkdetDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDK----KCASYYSDKVGGVLRFRNYSLKTid
|.. .| || . .   .. |. | |   .        . . || ||.| .. | .|   |.|| | | . .     || |. ..||. |.| . ..|   
fnddyiHAnrvtcpnglrliltqsPqeki.......tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC..

iktdlAEFTDKKDFTLYTVEITnYrknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCL-KKKVT
      .   ..|.   ..... .    .|.. ||.  |.. | .  ....   .|..... ...|  |.||| .|. |  .| ||. |  .   ... .
.....kskekeddvetRelvvk.f...ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

QIIDIILPVRQCRHGAVQDDTQVTYILLCVTkglmekmpvpylrsfdavqYYHKQLLNNFYHP
.. |..  .|. |  |...... ....  .                     . .. |..|...
kledvlkalrkqralaitsalelafvdagiv...................llaievldqfaee

subfamily_PTPRB_pd Subfamily PTPRB 824-1052 1.6e-26 88.0 In-house 79-288 (293) alignment
Range on Protein: 824-1052
Range on HMM: 79-288/293.0
NPFINANVMM--FGKIEWIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlrfrNYSLKTIDIKTDL
. .|||| .     . |.| .|||. .              | .. | .. .... | | |   ||.  .||  |. ..        . .    ||| .|
sDYinanyipgynsprefiatqGPlpe..............tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad........eepvlyGdikvtl

AEFTDKKDFTLYTVEITNyrknkGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVT
 . ....|... ...|..     ......|  . . .||.|| |... . |....  ....      . ..|||| |||||||..|..  ..   .. . 
vaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyv

QIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
.|. |.  .|. |   ||  .|  .|  || . |..|
difgivaelReeRnllvqtekqYifihqcvldllrkk

0049772 (Phosphotyrosine protein) phosphatases II 824-1038 2.6e-15 52.4 In-house 72-269 (314) alignment
Range on Protein: 824-1038
Range on HMM: 72-269/314.0
NPFINANVMMFGkIEWIMAQGPMDgtekkkdetdkpkrSTCEKH----------WALI--EQHNVAICVQ---------------------LCGFVEGEd
  .|||. .      .| .|||..               |..            | ..  ...|| . |                      |... ..  
sdyinasyvdgf.lkfIatqgple..............itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.

kkcaSYYSDKVGGVLRfrnyslktidiktdlAEFTDKKDFtlytveitnyrknkgeqKKTVDILLYSAWPEHGAPQEAYpALEILKFCET--YKKNVLVH
    .... .    |.                | .|...|                 ....  .|.  .| ..|| ...  .|.|.|.|.   ...||||
....neptaadlellk...............eelydpelf.................erlgikylripvpDgsaplled.fdeflefieeadkggpvlvH

CSEGVGRTGTLVAIKYgidLCLKKKVtQIIDIILPVRQCRH-----GAVQDDTQV
|. |.|||||.|.. |   |... .|  . ...  ||..|.     |...   | 
CkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfieqleqy

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 825-1044 1.5e-25 84.7 In-house 49-259 (270) alignment
Range on Protein: 825-1044
Range on HMM: 49-259/270.0
PFINANVMMfgkiewimaqgPMDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaef
 .|||| .             .|| .||   .  |. .| ...| .| ...|   | . |..|   |||. |.. ...  .....  .|.. ...     
aYinAnyvr...........GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalse.....

TDKKDFTLYTVEITnyrkNKGEQKKTVdILLYSAWPEHGAPQEAY------PALEILKFC----ETYKKN--VLVHCSEGVGRTGTLVAIKYGIDLCLKK
. .. . |  ....    .|||... |    | .||.||.|.|.         |..|.      .  .|.  .|||||.||||||||.|. ... |  ..
ekeegyiltrlrle....ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeet

KVTQIIDIILPVRQCRHGAVQDDTQVTYILLC
|  ... ||  .|. |   ||   |....   
kkvdvlaiieelRkdRmalvqhpeqyeflyka

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 826-967 7.9e-10 33.1 In-house 61-182 (297) alignment
Range on Protein: 826-967
Range on HMM: 61-182/297.0
FINANVMMFG----KIEWIMAQGPMDgtekkkdetdkpkrSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTidiktdL
.|||. ..|     .. .|.||||..              .| . .| |. ...| . | .. . |.  .||| |. . |.. |.  .. ..       |
yinadyvvfpdeeadlkyilaqGpls..............atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvef......l

AEFTDKKDfTLYTVEITNYRKnkgEQKKTVDILLYSAWPEHGAPQE
....|. | ...  |.. . .   .... |    . .||.|| | .
sstsdefd.rviltelqliyr...sesrvvrhvqflswpdhGvpsd

subfamily_PTPN12_pd Subfamily PTPN12 827-1052 5.9e-32 105.7 In-house 71-280 (290) alignment
Range on Protein: 827-1052
Range on HMM: 71-280/290.0
INANVMM--FGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDiktdlaEF
||||..    ||.|.| ||||.                | . .| .| ..|| | | .|  || . |||. |......  |.| ........      | 
inanfikgvegkleyiaaqgPL..............pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee......ek

TDKKDFTLYTVEITNYrknkgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKV---TQI
. ..||.. |.....      .....|  . | |||.|| |. | . ||...  .....     ..|||| |||||||..|| |  .|  ..|.    ..
avdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldv

IDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
 |..| .|. |. .||   | ...  .|.. . ..
fdlvlelrkqraalvqtkeqyelvykavaelvqke

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 828-1044 1.2e-23 78.3 In-house 66-276 (301) alignment
Range on Protein: 828-1044
Range on HMM: 66-276/301.0
NANVMMFGKIE-----WIMAQgpmdGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLA
  .|.  ||       || ..    |  ..   |  | ..|.|  ||.. |..|   | |. .|| . .||..|.. |..  |.   ...|. . .. | 
avevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkeliln

EFTDKKdftlyTVEITNYRknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIIL
. . |.     |.|...    .  . .||    || |...| |.      .....    .| ..||||.|.||. .... .|     . ..  .. . . 
kkiskr.....tlevedst..gkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealk

PVRQCRHGAVQDDTQVTYILLC
 .|. |  .||  .|. .. | 
hlrehrwngvqtnsqlywmtlG

0043147 (Phosphotyrosine protein) phosphatases II 838-1042 2.4e-22 74.9 In-house 21-154 (172) alignment
Range on Protein: 838-1042
Range on HMM: 21-154/172.0
EWIMAQGPmdgtekkkdetdkpKRSTCEKHWALIEQHNVAICVQLCGFvegedkkcasyysdkvggvlrfrnyslktidiktdlaeftdkkdftlytvei
..|. |||               |.|....|... .... . | |...                                                    
rfiatqgp..............lrntladfwrmlkelgithivnltel....................................................

tnyRKNKGEQKKTVDILLYSAWPEHGAPqEAYPALEILKFCET-----YKKNVLVHCSEGVGRTGTLVAIKYGIdlclkkK-VtQIIDIILPVRQCRHGA
    ...   ....  .||  || ||.|  .   ||.|.|...      .. |||||| ||||||||||. . .      . .  . ...  ||..| ||
...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpga

VQDDTQVTYIL
|| . |  ...
vqnpsqyrfly

0051082 (Phosphotyrosine protein) phosphatases II 839-1044 6.4e-17 57.0 In-house 15-148 (151) alignment
Range on Protein: 839-1044
Range on HMM: 15-148/151.0
WIMAQGPMDgtekkkdetdkpkrstceKHWALIEQHNVAICVQLCGFVEGEdkKCASYYSDKVggvlrfrnyslktidiktdlaeftdkkdftlytveit
 .  .||..                   ...|......   | |.. .| .  .|..|. .                                       
lyrsggpla..................dflellkelgiktivnlrseeerg..ycpeylpelg.....................................

nyrknkgeqkKTVDILLYSAWPEHGAPQEAYPALEILKFCETY-KKNVLVHCSEGVGRTGTLVAIKYGIdLClkkkvTQIIDIILPVRQCRHGAVQDDTQ
           .|  . .  ||..| |.    .||.|....   ...|||||| |.||||||||.   . |        . ...  .|..|.|.||  .|
..........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

VTYILLC
  ..|..
flfqlfa

0036282 (Phosphotyrosine protein) phosphatases II 840-1042 1.4e-23 78.9 In-house 20-163 (174) alignment
Range on Protein: 840-1042
Range on HMM: 20-163/174.0
IMAQGPMDgtekkkdetdkpkrstcekHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvggvlrfrnyslktidiktdlaeftdkkdftlytveitn
|  |||..                   .|... .... . |.|.  .| .  ||  |...                                        
iagqgpla...................fwemlkelgittvvmlleekelglykcinywpe........................................

yrkNKGEQKKTVDILLYSAWPEHGAPQEAYpALEILKFCETY-----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLkKKVTQIIDIILPVRQCRHGAVQD
   ..   ....  .||  || ||.|  .   ||..||.|..     .. |||||| ||||||||||. . . . |  .. ...|..  .|..|.|.|| 
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

DTQVTYIL
. |  .. 
psQyrfly

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 846-1042 6.3e-19 63.1 In-house 40-232 (237) alignment
Range on Protein: 846-1042
Range on HMM: 40-232/237.0
MDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVggvlRFRNYSLKTIDIKTDlAEFTdkkDFTLYTVEITNYRKNKg
.||| ||   .. |  |.|.  | .. | . .. | | |..||...||  |. .      . . |   |. .| .  ||.   |.|. .. ...  . | 
fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd....qpaaygvltvslkkk.eefs...dytvrslllskrltlk.

eQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVT
 . . .    ...||..| ||..   | . |               ..||| |||||| .. |   .  . .||| .| . .  . . |   .|   |  
.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyv

YIL
.| 
fih

subfamily_PTPN9_pd Subfamily PTPN9 846-1045 1.7e-16 55.2 In-house 78-286 (297) alignment
Range on Protein: 846-1045
Range on HMM: 78-286/297.0
MDGTEKKKD--ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYRKn
.|| ..||    |  | . |.. .| .. ...| . |    .||    ||. |. .. . . .| ..|........       ..|..  ..||.| .. 
vdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.......eedykvrvleiknvkt.

kgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK-----------------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQ
  |....|    . .||..| |..|   |..|.    ..                   ..|||| |.|||||.... . ..   .. . .... .  .|.
..eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrt

CRHGAVQDDTQVTYILLCV
 |  ..| . | ..  |.|
qrafsiqtpeqyefcylav

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 848-1045 1.2e-20 68.7 In-house 24-217 (255) alignment
Range on Protein: 848-1045
Range on HMM: 24-217/255.0
GTEKKKDETDKPKRS-TCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDiktdlaeftDKKDFTLYTVEITNYRKNKgE
. . .||.  |   | | .| .  | | .    | || | | . .|| ||.  .  . |.. . .. | .            |  | |.||| .  .|  
hvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.........ssadvvlrtleitstlgek.k

QKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYkKNVLVHCSEGVGRTGTLVAIKYGID---LCLKKKVTQIID---IILPVRQCRHGAVQDDTQVTY
. .||    |  |.|. ||..|   |.|||      | |.||||.|.||. ..| . .      . |..  |  .|   ..  .|. |..|...  |...
kthtvkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

ILLCV
 .| |
silmv

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 848-1045 2e-20 68.1 In-house 84-276 (318) alignment
Range on Protein: 848-1045
Range on HMM: 84-276/318.0
GTEKKKD--ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlRFRNYSlktiDIKTDLAEFTDKKDFTLYTVEITNyrkNKG
| ..||    .  |   |.|  | .. . | |. | |   .|   .|.. |. .|       |.|     ... .| | .. .|..| ....|.   .. 
GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.....gsrsyg....klvvelkeevelsdyvlrefkvtr...tee

EQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK-----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTY
|....|    | .||..| |...   |....  ....     . ..|||| ||||||. .|..  ..   . ..  . ...  .|. |   || . | ..
eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyef

ILLCV
|   .
iydvl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 848-1045 4.6e-16 53.4 In-house 80-289 (301) alignment
Range on Protein: 848-1045
Range on HMM: 80-289/301.0
GTE--KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDiKTDLAEFTDKKdFTLYTVEITN--Y--R
|.   ||   .. | ..|    | || |. ..  | ...  ||  .||  |...      .| . . . .. .. . .|. .. ...   . .|  |  |
gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvn.eqvyPdfvirq.lnvkiqdgsnngyier

K-NKGEQKKTVDILL--YSAWPEHGAPQEAYPALEIL-----KFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQ
| .. ..|.. |.|      ||..|  .|    |...     .     .  |.||||..|.|.|. ...  |.. |    |  .....  ||. . |||.
kfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

DDTQVTYILLCV
   | | |   .
TLeqytsiydvi

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 848-1046 4.5e-15 50.5 In-house 48-237 (239) alignment
Range on Protein: 848-1046
Range on HMM: 48-237/239.0
GTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNyslktIDIKTDLaeFTdkkDFTLYTVEITNYRKNkgEq
|. |    |.     ..   | .. |   .. | | |..||  |||  |. |       .|         ||..  |.   |. . |. ...  .   | 
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv.....tlrktev..fa...dyiirtfvmsqvgqt..e.

KKTVDILLYSAWPEHGAPQEAYPALE----ILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
.. |    .. ||..| || |   |     | |      .  ..||| ||||||... |   .  . |.|  .|.. .  .|. |   ||   |  .| |
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

CVT
.| 
avl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 848-1045 5.5e-15 50.2 In-house 49-237 (239) alignment
Range on Protein: 848-1045
Range on HMM: 49-237/239.0
GTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNyslktIDIKTDLaeFTdkkDFTLYTVEITNYRKNkgEq
|. |    |.     ..   | .. |   .. | | |..||  |||  |. |       .|         ||..  |.   |. . |. ...  .   | 
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv.....tlrktev..fa...dyiirtfvmsqvgqt..e.

KKTVDILLYSAWPEHGAPQEAYPALE----ILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
.. |    .. ||..| || |   |     | |      .  ..||| ||||||... |   .  . |.|  .|.. .  .|. |   ||   |  .| |
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

CV
.|
av

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 851-1050 8.9e-27 88.9 In-house 82-278 (307) alignment
Range on Protein: 851-1050
Range on HMM: 82-278/307.0
KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSlKTIDIKTDLAEFTdKKDFtlYTVEITNYRKNKGEQKKT
||   .. |. .|  . ||.. |..|   . ||  .|    ||  |.  . |  | | . . .|| ..   |.     |     ...|. . . ... .|
kkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap.ntisvanlgakkl.apde..dlinvttlkvdwaqksrt

VDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGL
.. | .. ||..|.||    |...|.  .  .  |.|||| ||||.||.||| .  |  ..     .. ...  .|. || |.|.. |  |.   . . .
iqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

M
.
l

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 851-1053 3.4e-22 73.4 In-house 96-293 (305) alignment
Range on Protein: 851-1053
Range on HMM: 96-293/305.0
KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLktIDIKTDLAEFTDKKDFTLYTVEITnYrknKGEQKKT
|.   .. |   | .. | .. |..|   | ||  ||    ||| |.    |  | ...  .  ..  .    .    .  . ....| |    |.|| .
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgiv..venvsgskpmerdaeiqitllnlt.y...sgdqkms

VDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDL-CLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGL
|  | .. ||. | |     .||.|      |  ..|||| |.|||||.|||.| ..  . .|..  . ...  .|. |  ..|.| |  .|   . . .
vrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

MEKM
.|| 
leky

subfamily_PTPN6_pd Subfamily PTPN6 851-1046 4.2e-22 73.5 In-house 98-294 (306) alignment
Range on Protein: 851-1046
Range on HMM: 98-294/306.0
KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLrFRNYSLKTIDIKtdlaeftDKKDFTLYTVEITNYrkNKGEQKKT
|.   |.   ..| .  | .. | |  . | .   ||   .||| |. |.      . ..|..... |       ...|..| .. ...   .|......
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.......sladYilRelsvskk..kkkkeere

VDILLYSAWPEHGAPQEAYPALEILKFCETYKKN--------VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDI---ILPVRQCRHGAVQDDTQVT
|  . . .||.|| |.. .  |. |.  .. ...        ..||||.|.|||||.. |   ..|  ||..   |||   .  ||. | | || ..|  
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

YILLCVT
..   ..
fvykaik

subfamily_hpo-7_pd Subfamily hpo-7 852-1054 3.8e-19 63.6 In-house 31-232 (263) alignment
Range on Protein: 852-1054
Range on HMM: 31-232/263.0
KKDETDKPKR----STCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaeftdkkDFTLYTVEITNYRKNKgEQ
.||.  |        | .| .  |.| .    | || | | . .|| ||.  .  . ... | .. | ...          |  | | |.... ..|  .
ekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.........dvllktlellstlgeK.kk

KKTVDILLYSAWPEHGAPQEAYPALEILKFCETYkKNVLVHCSEGVGRTGTLVAIKYGID---LCLKKKVTQIID---IILPVRQCRHGAVQDDTQVTYI
 .||    |  |.|. .|..|   |.|||      |.. ||||.|.||.   . .        . |..  |  .|   ..  .|. |..|...  |. . 
thtvkhysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs

LLCVTKGLMEKMP
.| | . ... ..
ilmvLdfvlnnfa

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 854-1042 7.6e-25 82.5 In-house 76-261 (274) alignment
Range on Protein: 854-1042
Range on HMM: 76-261/274.0
DETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLrfrnySLKTIDIKTDLAEFTDKKDFTLYTVEITNYRKNKGeqkktVDI
  |  |  .| .  | .| |..| . | |  . | . .||| |. |. .  .     | . .|..    . ....|... .. . .  ...      |  
vatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei.....serygdveikvekiverndysvrklvlkylerers.....vkh

LLYSAWPEHGAPQEAYPALEILKFCETYKK-------NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
 .|..||.| .|..| . |....  |. ..        |.|||| |.||||  .||. ..    ...|  .. |.  .|. | | || . |  .| 
ywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelih

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 855-1046 1.8e-25 84.5 In-house 94-276 (288) alignment
Range on Protein: 855-1046
Range on HMM: 94-276/288.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVggvlRFRNYSLKTIDiktdLAEFTDKKDFTLYTVEITnyrknKGEQKKTVDIL
 |  |  .| .. | |. ....   | | ..|||...||  |. |.     . .||   |.     | |  ...||.| ....      | ... ..  .
atqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad....kpknyGsvtvt....lveskeledfvlrkllle.....kkkteleitqy

LYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
 | |||.|| |. . | ||.|.  .. .    ....||||.||||||| .|..  ||   ....  .....  .|. |   ||  .|  .|  .. 
qylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPRG_pd Subfamily PTPRG 855-1042 1.7e-22 74.4 In-house 95-280 (563) alignment
Range on Protein: 855-1042
Range on HMM: 95-280/563.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdLAEFTDKkdftlyTVEITNYRKNKG---EQKKTV
 | .| ..|..  | .| ..|||| | .  .|| . .||  |.     ..... . ... |. .. ||  | .      |. | | ...|.   ...|.|
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev.lalytvr......tlviknlklkkkkqcdteklv

DILLYSAWPEHGAPQEAYPALEILKFCETYKKN----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
    |. ||.||.|. . | |   |  .. .|.    ..||||.|||||||.....  .    .... .. ...  .|  |   ||.  | ... 
rqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflh

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 855-1043 8.2e-21 69.4 In-house 95-277 (319) alignment
Range on Protein: 855-1043
Range on HMM: 95-277/319.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlRFRNYSLKTIDIKtdlaEFTDKKDFTLYTVEItNYRKNKGEQkKTVDIL
 |  |.  | |  | .. .... | | |.. ||  . |.  |....      | .|   .....    |   ..|.    ... | .... |  ..|   
atqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.....nfeeyGrlivtle....eeeeledyiirklkl.nkkssevet.Revkhf

LYSAWPEHGAPQEAYPALEILKFCETYKKN-----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
 | .||.|. |..|   |..||  .  ...     . ||||.||||||| ....  ..   .  |  .  ..  .|  |   ||   | ..|  
qyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiye

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 855-1050 8.1e-19 62.9 In-house 96-285 (297) alignment
Range on Protein: 855-1050
Range on HMM: 96-285/297.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGeDKKCASYYSDKvgGVLRFRNYSLKTIDIktdlaefTDKKDFTLYTVEITnyrKNKGEQKKTVDIL
 |..|...| .  ||.. ...|.. | |    |. ||||| |.|||  ||  | . |...  .       .... |   ..|.|   |.|  ... |.  
ttqmPmkatvadfWamvldeqvstivmlnddner.dkkcaryWsdk..gvttfGdvsvvllsv.......sereGfikrelevt...kgkakarrvvkqy

LYSAWPEHGAPQ-EAYPA-LEIL----KFCETYKK-NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 .  ||..  .. .  .. |...    |  .. ..  .||||. |||||| |..|.  .    ..|  .| ...  .|| |   || . | ...   | .
qfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle

GLM
 |.
all

subfamily_PTPRN_pd Subfamily PTPRN 855-1047 1.4e-16 55.0 In-house 104-290 (297) alignment
Range on Protein: 855-1047
Range on HMM: 104-290/297.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVlrFRNYSLKTIdiktdlAEFTDKKDFTLYTVEITNYRKnkgEQKKTVDIL
 |. |  ||  . | .. .. |.. |.|.   | . |.|. |. |.   |  .  | .. .      .|    .|. . .  . | ..   .. .||  .
atqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev..yhiyevhlv......sehiwcddylvrsfylknlqt...setrtvtqf

LYSAWPEHGAPQEAYPALEIL-KFCETYK---KNVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 . .|||.|.| .| . ||   |   .|.     ..||||.|.||||. ..|   ..  ||  |  .|.  .  .|. |.| |.   |  ..| .|..
hflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_PTPN14_pd Subfamily PTPN14 855-1044 5.1e-16 53.5 In-house 97-291 (300) alignment
Range on Protein: 855-1044
Range on HMM: 97-291/300.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlRFRNYSLKTIDIKTdlaEFTDKKDFtLYTVEITnYRKNKGEQKKTVDIL
 .  | . |....| .. ...|.. |.|    |.  .|. .|. ..     . ..   .   . |   .|... |  . |  ..  .    ....|| .|
vaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles...kkktvefgkfkvtt...kfsedsds.vittglk.lkhlpskeertvwhl

LYSAWPEHGAPQEAYPALEILKFCETYK-------------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
 |  ||.|| |..  . |. |.  .  .               ||||||.|||||| |.     |    . .. .|  ..  .|. |   ||  .| ...
qytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv

LLC
   
Ykv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 855-1066 8.6e-15 49.0 In-house 92-254 (392) alignment
Range on Protein: 855-1066
Range on HMM: 92-254/392.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEdkkcasyysdkvggvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknKGEQKKTVDIL
 .. |. .. .  | .. |.||.  . .  . ||.                                                      ||....||   
asqgpnaaslddfwrmvfqenvttiamvtklkegd......................................................kgddartvaqf

LYSAWPEHGAPQEAYPALEILKFCE----TYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLM
 .. ||... |. .   |...|  .     | . ...||| |||||| ...|   .  . | .. ......  .|. |   || . | ..|  .| . |.
hftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

EK-MPVPYLRSFDAVQY
 .   .| ..  | .| 
wrntlipvvhftdhlqd

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 855-1045 1.2e-14 48.6 In-house 95-275 (439) alignment
Range on Protein: 855-1045
Range on HMM: 95-275/439.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDkkcasyysdkvggvlrFRNYSLKTI--DIKTDLAEFTDKKDFTLYTVEITNYRkNKGEQKKTVD
.|. ||. |... | |. .....  |.|. .||                   .   . ...  ||        .  ....  . . | | ...|...|| 
atqgpkkettddfwrlviekktvtivmltnlvesyk................ywpsdaevcygdiavrvdrnielpnyvirgfkvfner.dttekertvl

ILLYSAWPEHGAPQEAYPALEILKFCETYK-----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
 . | |||..  | .|   |. |.  .. .       |.|||| |||||||..|.   ..    ..  .|  |.  .|. |.  ||.  |  .|  .|
qfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav

subfamily_ptpA1_pd Subfamily ptpA1 855-1001 4.9e-07 23.8 In-house 93-248 (418) alignment
Range on Protein: 855-1001
Range on HMM: 93-248/418.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVlRFRNYSLKTIDIKTDLAEFTDKKDFTLYTVEITNYRKNKGEQKKTVDIL
 |. |   |    | .. .  . | | |    |    ||  |. ...||  .|  |      . |   |. .  .     .   | |     . . .   
ctqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqy

LYSAWPEHGAPQEAYPALEILKFCET--------YKKN--VLVHCSEGVGRTGTLVA
 |  ||.|  |. . |  ..|.              .|  ..|||| |||||||...
qyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 856-1047 5.9e-26 86.0 In-house 96-281 (290) alignment
Range on Protein: 856-1047
Range on HMM: 96-281/290.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvgGVLRFRNYSLKTidiktdLAEFTDKkDFTLYTVEITNYRKNkgEQKKTVDILL
|. |  .|  . | || |..|.| | |.  .| . .||  |..|.  .. .. ..|.|       | | | . ...  ..|..| ...  ..|..|  . 
tqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikl......lneetln.eyierklevknknsa..gakqsvtqyq

YSAWPEHGAPQEAYPALE-ILKFCE----TYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 ..|...|  ..    |  | .  .    . .. ..||||..|||.....|.. .|. | .. | ......   |... | ||   |. .|   | .
itnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

subfamily_PTPRD_pd Subfamily PTPRD 856-1045 8.2e-26 85.7 In-house 96-277 (564) alignment
Range on Protein: 856-1045
Range on HMM: 96-277/564.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGgVLrfrNYSlktiDIKTDLAEFTDKKDFTLYTVEItnyRKNKGEQKKTVDILL
|  |. .|.|  | .. ..|... | |   .| . .||..|. .| |      .|     ... .| | ....|... | ..   .|.| .....|    
tqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.te...tyg....eltVtleeeeeladyeirtfkl...kkkkssesreVrqFh

YSAWPEHGAPQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
. .||.||.|..| . |.... ......     ..|||| ||||||| ..|.. ..   ..|.  |  ..  .|. |   ||  .|  .|   .
FtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 856-1042 7.9e-24 78.9 In-house 93-280 (305) alignment
Range on Protein: 856-1042
Range on HMM: 93-280/305.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKtIDIKTDLAEFTDKKDFTLYTVEITNY-RKNKGEQKKTVDIL
|. |   ||   | .  |..|     || ..|   |||. |.. | . || |..   | | .| . ..  . .. .  .|. |    .  ||... |   
tqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk.isvkfessvtlkfrkdakakvtetvlviegpgekarkvthy

LYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQ-IIDIILPVRQCRHGAVQDDTQVTYIL
 .  ||. | |      ||.|. . . |  . |||| |.||||..| ..| .|  |  .. .    |.  .|. |  ..| |.|  .. 
hwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 856-1045 1.4e-23 78.3 In-house 91-274 (287) alignment
Range on Protein: 856-1045
Range on HMM: 91-274/287.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvLRFRNYSLKTIDIKtdlaeftDKKDFTLYTVEITNyrKNKGEQKKTVDILL
.. |  .|  . | ||...|| . | ||   | ....|  |....    . . .|... .. .        .....  ..|..|  ||| ..|..|    
aesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.......vnagyierklevkn..knkagdkqqvkqyq

YSAWPEHG-APQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
. .|...|  .. .   | | .   | .|     ..||||..|||.....|.  .|. | .  |  .....   |. . |.||  .| ..|   |
itnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindiv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 856-1052 3.9e-23 76.6 In-house 87-279 (312) alignment
Range on Protein: 856-1052
Range on HMM: 87-279/312.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVlRFRNYSLKTiDIKTDLAEFTDKKDFTLYTVeITNYRKNKGEQKKtVDILL
|. |  .|| . | |      .  . ||||||   .||| | || || |  . .. . | .  |..      ||   . | .    |  |.. | ..   
tqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfv.dledhrvyt.eycteieiggkskdkithrv.lkvvvkatgqesk.lnhyq

YSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
...||.|| |.    || .|      || |. ||| ||||||||. |.  |    . .  .. |. . .|. |  .|.   |  | | || . |. |
waswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 856-1066 1.1e-22 75.2 In-house 92-295 (315) alignment
Range on Protein: 856-1066
Range on HMM: 92-295/315.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDlAEFTDKKdftlytVeITnyrkNKGEQKKTVDILL
.  |.... .  | .. |..|.  | .    ||.  ||. |. |. .   .| ...........| .. . .|      . .|     |.|...||    
sqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead.tdgvark......l.vt....rkseesrtvtqfq

YSAWPEHGAPQEAYPALEILKFCE----TYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLM-
.  ||..|.....   |...|       ... ..||||| |||||| ...|.  ..   ....  . ...  .|. |   || . . ..|   | . |. 
ftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllw

EKMPVPYLRSFDAVQY
 .  .. ..  | .| 
rntlilvihftdhlqd

0046846 (Phosphotyrosine protein) phosphatases II 856-1046 2.9e-22 74.7 In-house 28-170 (176) alignment
Range on Protein: 856-1046
Range on HMM: 28-170/176.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvggV----Lrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqkktv
|. | ..|... .... .... . | |.  || .  ||. |...    .    .                                              
tqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..............................................

dILLYSAWPEHGAPQEaYPALEILKFCETYK---KNVLVHCSEGVGRTGTLVAikygIDLCLKKKVTQIIDIILPVRQCRH-GAVQDDTQVTYILLCVT
   |.  ||.||.|.     ||.|.|....    ..|||||| |.||||||||    ..|. ..|   . ...  ||..|. |||| . |. ..  .. 
.qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQyrflyefel

0049260 (Phosphotyrosine protein) phosphatases II 856-1042 5e-22 73.7 In-house 14-143 (152) alignment
Range on Protein: 856-1042
Range on HMM: 14-143/152.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYsdkvggvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqkktvdILL
|  | . |....| .. .... . | |. ..|    ||. |.                                                         |
tqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................................qyl

YSAWPEHGAPQEAYPALEILKFC----ETYKKNVLVHCSEGVGRTGTLVAIKYGIdlclkkKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
.  || ||.|. .   |..|.|.    .  ...|||||| ||||||||||. . .      .   . ...  ||..| |||.   |  ...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 856-1068 9.6e-22 71.7 In-house 91-296 (515) alignment
Range on Protein: 856-1068
Range on HMM: 91-296/515.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDlaefTdkkDFTLYTVEITnyrknKGEQKKTVDILL
.  |.... .  | |. |.||.  . .    ||.  ||. |. || |  ..| ....... ....    |   . .  .....     ||.. .||    
sqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac....t...ggikrkltvl.....kgddsrtvtqfh

YSAWPEHGAPQEAYPALEILKFC----ETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLM-
.  ||..|.|...   | ..|      . |.  ...||| |||||| ...|.  .    . ..  . ...  .|| |   || . | ..|   |   |. 
fteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw

EKMPVPYLRSFDAVQYYH
 .  .| .   | .|  |
rntlipvihftdhlqdlh

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 856-1047 1e-21 72.3 In-house 57-240 (250) alignment
Range on Protein: 856-1047
Range on HMM: 57-240/250.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKkCASYYS-DKVggvlrfRNYSlktiDIKTDLAEFTDKKDFTLYTVEITNYRKnkgEQKKTVDIL
| .|  .| |. | .. .....  | |  ..| | . .  |.  .|       ..|     |.. .| .   . |.|  .. .....|   .....|  |
tqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka......ekyG....dvtvsllskeefadytkrklklskakk...aderivrql

LYSAWPEHGAPQEAYPALEILKFCETYKKN-----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 . .||. | |..|  .||.||  .. ...     |.|.||.||||.|. .||.  ..   |.||  . ..|  .|. | .||.  .|  ..   . |
hfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk

subfamily_PTPRA_pd Subfamily PTPRA 856-1044 1.3e-21 71.8 In-house 106-290 (330) alignment
Range on Protein: 856-1044
Range on HMM: 106-290/330.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvgGVLRFRNyslktidIKTDLAEFTDKKDFTLYTVEITNYRKNK-GEQKKTVDIL
.  ||. | |  | .| ... |  | |  . | ...||| |. |.  |.. . |       |.  . . |  .|.|.  . ...  ...  .... |  .
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGn.......irvevedetvlvdytvrkflvqqlpdatrekksrlvrqf

LYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLC
 . .||. | | |.   |..||  .. .      . |||| |||||||.....  ..    ...  . ...  .|. |   || | | ..|   
hftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 856-1047 9.7e-21 69.4 In-house 109-289 (319) alignment
Range on Protein: 856-1047
Range on HMM: 109-289/319.0
TDKPKRSTCEKHWALIEQHNVAICVQLCgfvegeDKKCASYYSDKVggVLRFrnyslKTIDIKTDLAEFTDKkdFTLYTVEITNYRKNKGEQKktVDILL
.  |.  | .  | .| ..|..  | |        .||. |.  |.  | .      .  ..| |. | |..  ...  .|...  |.|. .|  .    
aqGPldntladfWrmiweyncstivllt......kdkcsqywplki..vike.....erfkvkvdsveetae..yvvrdielsedgkekdirk..itqfh

YSAWPEHGAPQEAYPALEILKF------CETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.  ||..| |. . . . ..|        |  ..|..|||| ||||||. ....  .|   ..|  .. ...  .|| |   ||| .|  .|   . .
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 856-1047 1.4e-20 68.9 In-house 73-253 (284) alignment
Range on Protein: 856-1047
Range on HMM: 73-253/284.0
TDKPKRSTCEKHWALIEQHNVAICVQLCgfvegeDKKCASYYSDKVggVLRFrnyslKTIDIKTDLAEFTDKkdFTLYTVEITNYRKNKGEQKktVDILL
|  |.  | .  | .| ..|..  | |       ..||. |.  |.  | .      .  ..| |. | ...  ...  .|...  |.|. .|  .    
tqGPldntladfWrmiweyncstivllt......kdkcsqywplki..vike.....erfkvkvdsveesee..yvvrdielsedgkekdirk..irqfh

YSAWPEHGAPQEAYPALEILKF------CETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.  ||..| |. . . . ..|        |  ..|..|||| ||||||. ....  .|   ..|  .. ...  .|| |   ||| .|  .|   . .
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 856-1042 7.2e-19 62.9 In-house 97-272 (315) alignment
Range on Protein: 856-1042
Range on HMM: 97-272/315.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlrfrN--YSLKTIDIKTDlaEFtdKKDFTLYTVeitnyRKNKGEQKKTVDI
.  |. .. .  | |. .....  | | . |||| .|.  |. ||        .  |   |.  | .  |   ....|  |.         |.. ..|  
aqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk........kviyGkitvtrkse..ev..nteytvrtl.....svvfgdnirevvq

LLYSAWPEHGAPQEAYPALEILKFCETYKKN----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
| |..||. | |. . | ... .    ...|    ..||||.|||||||.....  .|    ...  . ..|  ||| | ..||   |  .| 
lhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiy

subfamily_PTPN23_pd Subfamily PTPN23 856-1042 2.3e-18 61.0 In-house 88-273 (288) alignment
Range on Protein: 856-1042
Range on HMM: 88-273/288.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNyslktidIKTDLAEFTDKKDFTLYTVEITNYRKnkgEQKKTVDILL
|  |..||    | .. .  . . | |    | ...|...|.  . |   .| .       ..  | . .. . .  ......  ..   ...|.|  | 
tqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.......lsvtlksvretethvervlkletlda...davksvshlq

YSAWPEHGAPQEAYPALEILKFCET--------YKKNVLVHCSEGVGRTGTLvAIKYGI--DLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
. .|||.|.|.     |..|.  |.         |. ..|||| ||||||.. |. |..  .|  .. ...||...  .|. |.  ||. .|.   .
ltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf.alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsy

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 856-1025 6.4e-17 56.1 In-house 86-244 (281) alignment
Range on Protein: 856-1025
Range on HMM: 86-244/281.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaeftdKKDftLYTVEItNYrKNKGEQKkTVDILL
|. ||. |    | .| | | .  | || |.| . .||| |.  .   .|.| ..|..  |          .|   | |  . |    .|| .  .   |
tqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstv.......nks..lvttrl.nl.syegetr.lithwl

YSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLK-KKVTQIIDIILPVR
.  ||.   |. .   |.||.   .     ..||| ||||.|||.|..  ..       . .| .|.  .|
wkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlr

subfamily_CG7180_pd Subfamily CG7180 856-1046 2.4e-16 54.2 In-house 90-287 (296) alignment
Range on Protein: 856-1046
Range on HMM: 90-287/296.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDkKCASYYSDKVggVLRFRNYSLKTIDIKTdLAEFTDkKDFTLYTV--EITNYRKNKGEQKKTVDI
|. ||..| ...| |. ....   | |.   . .  .. ||.  |     ....  ....  |. .|...  . | |.     .|. .|.   ....|  
teapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekq.yanlki.rtfkltkkivalteqekqvkaetRivkl

LLYSAWPE-HGAPQEAYPALEILKFCETYKKNV---------LVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
. .  |.  .  |  .   .|...  ......|         .|..|.|..|.|  .||   ..|  |..  .. . .  .|. | . |.  ..  ||  
fqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd

CVT
 . 
vll

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 856-1053 3.4e-14 47.7 In-house 96-288 (325) alignment
Range on Protein: 856-1053
Range on HMM: 96-288/325.0
TDKPKRSTCEKHWALIEQHNVAICVqLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKtdlaEFtdkKDFTLYTVEITNYrkNKGEqKKTVDILL
.  |. .| .  | |. . . .. | .   .......|| |. ...|   .|    .| . |.    |.    |.    ... .   .|||  ..|  . 
aqaPltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrtie....ei...sdyvhrvldvkqv..kkGe.trsvkqfq

YSAWPEHGAPQEAYPALEILKFCETY----K------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQvtYILlcV
. .|.. | ..     . ||.  ..     .        .|||||.||||||.....   ..  ...    | . .  .|. |   |.   |  |||  .
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdq..yil..i

TKGLMEKM
 ..|.| .
yealveay

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 856-1041 5e-12 40.4 In-house 77-251 (267) alignment
Range on Protein: 856-1041
Range on HMM: 77-251/267.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEdkkCASYYSDKVGGVLRFRNYslkTIDikTDLAefTDKKDFTLYTVEItnyrKNKGEQKKTVDILL
| .| . |  ... .| ...|.. | |    ...      ..  |.|   ....    |..    |    ...|. . |.|.    | | |  . | .  
tqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakkyqdl...tve..hsle..keendyqiitlel....kfknesahnvtlyy

YSAWPEHGAPQE-AYPALEILK--FCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
|  |      .    | . ||     |   . ..|.||.||||.||.. |.  ..   .  |..| | .. .|. | | |.   .  ||
ykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi

0051429 (Phosphotyrosine protein) phosphatases II 857-1056 1.1e-24 83.0 In-house 28-232 (272) alignment
Range on Protein: 857-1056
Range on HMM: 28-232/272.0
DKPKRSTCEKHWALiEQHNVAICVQLCGFVEGEDKKCASYYsdkvggvLRFRNYSLKTIDIKTDLAEFTD----------KKDFTLYTVEITNYRKNKGE
. | . |..  |.| .....   | |.. .| .  ||  |          .| . | ..|  .   .. .          . |..|.. ..|.. ...  
ggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.......pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

qkKTVDILLYSAWPEHGAPQEAypALEILKFCETyKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQ--------IIDIILPVRQCRHGAVQDDTQV
   .| .|.| .|| ||.||||   ||.|... . ...|||||| |..||||.||. . .    .  . .        . ...  .|..|.||||...|.
..revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqy

TYILLCVTKGLMEKMPVP
 ... .. . |.. . |.
lflyeallellrsllsvr

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 858-1040 7e-10 33.1 In-house 87-268 (287) alignment
Range on Protein: 858-1040
Range on HMM: 87-268/287.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGGVLRFRNYSLKTIDIKTDlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILLYS
 |  .|  . | .. ....|  . .   ||   .||  |. ..    .|   ||.  .| .        . ...  .. . .    .... . |  | . 
gPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydik......ePeygvralrlidl...etrearvvkqldll

AWPEHGAPQE----AYPALEILKFCETYKK-----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTY
.||.....      .  .|.. .. |  ..      ..||.. |.||.|.|.|.   ..  ..     .  ... .|. | . ||   |. .
swPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 858-1042 1.4e-08 28.7 In-house 101-283 (310) alignment
Range on Protein: 858-1042
Range on HMM: 101-283/310.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkVGGVLRFRNYSLKTIDIKTDLAEFTDK-KDFTLYTVEITNYRKNKgeQKKTVDILLY
 | . |    | .| |      . ||  .|    || .|.   .|    .    .  .   ..  |  .    |    | . .   |   ..  |... .
gplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanl..kelrvslikw

SAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
  ||. | |.|   ..    ...  .  ..|||| |..|....||.|. ||   . .  .. ...  ... |   .| . | ..| 
pnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 858-1033 7e-06 20.3 In-house 11-187 (198) alignment
Range on Protein: 858-1033
Range on HMM: 11-187/198.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTidiKTdlaeFTDKKDFTLYTVEITNYRKNKGeQKKTVDILLYS
.| | |    | .. .      | .       .   . |..    |. .. . |. |   ||     | | |.|. .. .||         . .    ..
hplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt...kt....ittkpdytitaliltnnttapp.streishyqft

AWPEHGAPQEAYP------ALEILKFCETYK-KNVLVHCSEGVGRTGTLVAIKYGIDLCL--KKKVTQIIDIILPVRQCRHGAVQ
.| |. .|. |        . |. |  |  |   |.||||.| | || .||.  |.      |  | .....   .||.| | . 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 858-1033 7.3e-06 20.3 In-house 12-188 (199) alignment
Range on Protein: 858-1033
Range on HMM: 12-188/199.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTidiKTdlaeFTDKKDFTLYTVEITNYRKNKGeQKKTVDILLYS
.| | |    | .. .      | .       .   . |..    |. .. . |. |   ||     | | |.|. .. .||         . .    ..
hplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt...kt....ittkpdytitaliltnnttapp.streishyqft

AWPEHGAPQEAYP------ALEILKFCETYK-KNVLVHCSEGVGRTGTLVAIKYGIDLCL--KKKVTQIIDIILPVRQCRHGAVQ
.| |. .|. |        . |. |  |  |   |.||||.| | || .||.  |.      |  | .....   .||.| | . 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 864-1046 5.1e-06 20.1 In-house 106-282 (302) alignment
Range on Protein: 864-1046
Range on HMM: 106-282/302.0
CEKHWALIEQHNVAICVQLCGFVEGEDkKCASYYSDKVGgvlRFRNYSLKTIDIKTdlAEFTDKKDfTLYTVEITNyrkNKGEQKKTVDILLYSAWPEHG
 |. | .. |....  | | |  | .      ..  | |    . .|    . ..    | ....  | |..|.     .   .   . . . . |... 
veeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg...dykeygkmfvNnrk..Vekaeeek.tryviEvlP...egcsnsvlanvyvltnWkqkk

APQEAYP----ALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
 |..       | .. .  .  ..|...   .|.|| |....    ..   |.|  .| .|.  .|. |  ||.  .| . . ... 
vpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall

0044763 (Phosphotyrosine protein) phosphatases II 865-1047 3.6e-19 64.6 In-house 38-169 (178) alignment
Range on Protein: 865-1047
Range on HMM: 38-169/178.0
EKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqkktvDILLYSAWPEHGA
.....|. ....   | |.. .|.   ||  |. .. |                                                    |.  .| ||.
addlellkelgithivnlteelelgflkcdpywpeeag.................................................iqylhipipDhgv

PQEAYPALEILKFCE----TYKKNVLVHCSEGVGRTGTLVaikyGIDLCLKKKVtQIIDIILPVRQCRHgAVQDDTQVTYILLCVTK
|.     ||...|.|    . ...|||||| ||||.||||     ..|..| ..  . ..|  ||..|  .|. . |. .....  .
pdllehflefvefieealdekggpvlVHCsaGvgRsgtlv....aaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefelr

DSPc Dual specificity phosphatase, catalytic domain 922-1001 1.5e-07 26.4 Pfam-A 11-92 (133) alignment
Range on Protein: 922-1001
Range on HMM: 11-92/133.0
AEFTDKKDFTLYTvEIT-NYRK---NKGEQKKTVDILlYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVA
 ....|...||   ..| . ..    | .... ..|       |    .|   | |... .|. .|.|||||  |. |..||..
lalleklgitlvi.nvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

DSPc Dual specificity phosphatase, catalytic domain 922-1001 1.5e-07 26.4 In-house 11-92 (133) alignment
Range on Protein: 922-1001
Range on HMM: 11-92/133.0
AEFTDKKDFTLYTvEIT-NYRK---NKGEQKKTVDILlYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVA
 ....|...||   ..| . ..    | .... ..|       |    .|   | |... .|. .|.|||||  |. |..||..
lalleklgitlvi.nvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

0048076 (Phosphotyrosine protein) phosphatases II 934-1045 3.5e-17 57.9 In-house 35-139 (145) alignment
Range on Protein: 934-1045
Range on HMM: 35-139/145.0
TVeitnyRKNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETY---KKNVLVHCSEGVGRTGTLVAIkygiDLCLKKKVTqIIDIILPVRQCRHG
..       ..   ....  .||  || ||.|. .   ||.|.|.|..   ...|||||| ||||||||||.    .|.|...|. . ...  ||..|.|
nl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa....ylmlllgvs.leealelvrsqrpg

AVQDDTQVTYILLCV
||. . |. ......
avpnpgqlrflyefe

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 945-1050 7.4e-09 29.4 In-house 85-195 (440) alignment
Range on Protein: 945-1050
Range on HMM: 85-195/440.0
GEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET-YK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVT
| . .|.    | .||..| |. | | |....  .   .      .||||| |.|||| ..|.   .  . .    .|. .|  .|. |   ||   | .
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

YILLCVTKGLM
..  .| .||.
fvheavlegll

PTPc_motif_SM00404 948-1002 2.9e-07 25.5 In-house 47-100 (140) alignment
Range on Protein: 948-1002
Range on HMM: 47-100/140.0
KKTVDILlYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAI
.. . |   .   .    ..   .|.... .|. ...|||||  || |..||.. 
fqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

PTPc_DSPc_SM00012 951-1045 8.4e-21 69.5 In-house 2-103 (105) alignment
Range on Protein: 951-1045
Range on HMM: 2-103/105.0
VDILLYSAWPEHGAPQEAYPALEILKFCETYKK------NVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILL
|  . |..||.||.|.|. . ||.|. ... |.      .|.|||| |||||||.||. . .. . |. |  .| .|.  .|. |.|.|| ..|. ... 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CV
..
al

0048179 (Phosphotyrosine protein) phosphatases II 951-1043 7.6e-17 56.8 In-house 49-139 (144) alignment
Range on Protein: 951-1043
Range on HMM: 49-139/144.0
VDILLYSAWPEHGAPQEAYPALEILKFCETY---KKNVLVHCSEGVGRTGTLVAIkygiDLCLKKKvTQIIDIILPVRQCRHGAVQDDTQVTYILL
.  .|.  || ||.|. .   ||.|.|.|..   ...|||||| ||||||||||.    .|..|..   . ...  ||..| |||. . |. ..|.
giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa....ylmkklg.lsleealalvrsrrpgavpnpgqlrfLle

0038934 (Phosphotyrosine protein) phosphatases II 971-1041 1.6e-07 26.7 In-house 99-169 (194) alignment
Range on Protein: 971-1041
Range on HMM: 99-169/194.0
ALEILKFCETY-----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLkkkvtQIIDIILPVRQCRHGAVQDDTQVTYI
 |..|......     .. |.|||  |.||||||||      |..        . |  .|..| ||..   .. ..
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.....saeeAialfrekRpgaipnqdyleal

subfamily_CDC14_pd Subfamily CDC14 973-1036 3.6e-06 21.0 In-house 254-312 (328) alignment
Range on Protein: 973-1036
Range on HMM: 254-312/328.0
EILKFCETYKKNVLVHCSEGVGRTGTLVAIkYgidlCLKKKVTQIIDIILPVRQCRHGAVQDDT
. |. .|. . .. |||  |.||||||.|  |     .|.   .  ..|  .| || | |    
kfleiaekaeGaiavhCkaGLGrtGtLiac.y....lmkhyrftaaeaiawlricrPGsvigpq

subfamily_DSP23_pd Subfamily DSP23 973-1037 7.9e-06 20.6 In-house 75-134 (148) alignment
Range on Protein: 973-1037
Range on HMM: 75-134/148.0
EILKFCETYKKNVLVHCSEGVGRTGTLVAIKYgidlcLKKKVTQIIDIILPVRQCRHGAVQDDTQ
....  |  .. | |||  | |||||..|  .     .|..     . |  ||. | |.|.   |
rvveeaeekneavsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 975-1047 5.9e-07 23.6 In-house 221-293 (297) alignment
Range on Protein: 975-1047
Range on HMM: 221-293/297.0
LKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
|.     .  .||||| ||||.| .|  .  ..   ||.. ..  |.  .|. |   ||   | ...   | |
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

PTEN_1 982-1001 5.5e-06 21.3 In-house 130-149 (196) alignment
Range on Protein: 982-1001
Range on HMM: 130-149/196.0
KKNVLVHCSEGVGRTGTLVA
...|||||  |.||.||.||
gnvVlVHCkaGlgRsGtvva

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 983-1004 3.8e-06 20.9 In-house 263-284 (350) alignment
Range on Protein: 983-1004
Range on HMM: 263-284/350.0
KNVLVHCSEGVGRTGTLVAIKY
. .||||| |||||||||.. .
spilvhCsaGvGrtGtlvtlDs

subfamily_CG42327_pd Subfamily CG42327 984-1042 3.9e-08 27.3 In-house 249-308 (319) alignment
Range on Protein: 984-1042
Range on HMM: 249-308/319.0
NVLVHCSEGVGRTGTLVAIKYGID-LCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
 . ||||.||||||...|    |  |   |.   | ...  ||. |  ||..  |  .| 
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 986-1041 1.6e-06 22.4 In-house 2-57 (69) alignment
Range on Protein: 986-1041
Range on HMM: 2-57/69.0
LVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
.|||| | |||||..||   .     .|.  | . .  .|.||   | .. .  .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifi

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 987-1041 2.9e-06 21.5 In-house 2-56 (69) alignment
Range on Protein: 987-1041
Range on HMM: 2-56/69.0
VHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
|||| | |||||..||   .     .|. .| . .  .|.||   | .. .  .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi