Gene hpo-7 in Caenorhabditis elegans

Synonym: CELE_C40A11.5, hpo-7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily hpo-7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP112_AA protein Get Run
CeleP112_AA_0-188 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_hpo-7_pd Subfamily hpo-7 1-215 8.9e-91 298.4 In-house 1-255 (263) alignment
Range on Protein: 1-215
Range on HMM: 1-255/263.0
MILT-QGPIHWKTLPKSVDDVDECAQGVEPSRPP-----YS----TMDKFLQMIVQTKATDVVMLGDFYEN-----------------------------
..|. .|......||....|.|.|.....|....     ||    |.|||.|.|||||...||||.||.|.                             
kllndkgalkfgklPrilidedvctehfkPekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkv

--DVVLRTIEITSNFSKsKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQTPTVGLDYVKLI
  ||.|.|.|..|.... ||.|||..||.|||||..|.|||.|||||..|..|.|||.||||||||||.|||...||.||.|......|.||.|||..|.
qsdvllktlellstlge.KkkthtvkhysykgWiekndpelareilnilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLl

QDLRSMRAGAIYTPMQLAFSIIMLLDFVLENELSKETNIKYQQIRNSYLDLRKRKY
..|||.|..||.|||||||||.|.|||||.|    | . |||.||.|||  |.  .
eelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeirksylharqmmh

0040438 (Phosphotyrosine protein) phosphatases II 2-193 7.6e-33 109.5 In-house 89-282 (317) alignment
Range on Protein: 2-193
Range on HMM: 89-282/317.0
ILTQGPIhwktlpksvddvdecaqgvepsrppYSTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEI
|.||||                           .|...|..|. . . | .||| .. |.                               ...|||.|.
IatqgPl.........................pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlev

TSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSM
. .    ..|..|..|. |.||  .. |.  ...|. ..|||.     .. |.|||| |.||...|.  .|... .  ..      |.|. . .. ||..
edl...gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg......gvdveeavkelreq

RAGAIYTPMQLAFSIIMLLDFVLENELS
|.||..||.|. | . .||.... .. .
Rpgavqtpeqyrflydalleylkrkltl

0036941 (Phosphotyrosine protein) phosphatases II 2-191 2.7e-32 107.7 In-house 81-281 (297) alignment
Range on Protein: 2-191
Range on HMM: 81-281/297.0
ILTQGPIHwktlpksvddvdecaqgvepsrppySTMDKFLQMIVQTKATDVVMLGDFY-----------------------------------ENDVVLR
|.|||| .                         .|...| .|. . . | .||| ...                                   ..|..||
IatqgPlp.........................ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlr

TIEITSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqTPTVGLDYVKLI
|.|.| .    ..|..|..|. |.||   . ||  ...|. ...|||       .. |.|||| |.||...|.  .|..| .  .   . . |.|.....
tlevtdt...gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledk...lkeggvdileav

QDLRSMRAGAIYTPMQLAFSIIMLLDFVLENE
. ||..|.||. |..|. | . .||.... ..
kklReqRpgavqtleqyrflyeallellkkkl

0050432 (Phosphotyrosine protein) phosphatases II 2-188 3e-31 104.3 In-house 111-300 (308) alignment
Range on Protein: 2-188
Range on HMM: 111-300/308.0
ILTQGPIhwktlpksvddvdecaqgvepsrppYSTMDKFLQMIVQTKATDVVMLGDFYEN----------------------------------DVVLRT
|.||||                          ..|...| .|. . . . .||| ...||                                  |...||
IatqgPl.........................pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrt

IEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS---KSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtptVGLDYVKLIQDLRS
.|.|    ....|..|..|. |..|  .. |.  ...|. ...||||   . .||||| |.||...|.  .|... .  .       |.|. .... ||.
leltn...lgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke......ggvdvfeavkklRe

MRAGAIYTPMQLAFSIIMLLDFVL
.|.|.. ||.|. | . .||....
qRpgmvqtpeqylflyralleylk

0047943 (Phosphotyrosine protein) phosphatases II 2-187 1.7e-30 101.8 In-house 80-272 (273) alignment
Range on Protein: 2-187
Range on HMM: 80-272/273.0
ILTQGPIhwktlpksvddvdecaqgvepsrppYSTMDKFLQMIVQTKATDVVMLGDFYEN----------------------------------DVVLRT
|.||||                          ..|...|..|. . ... .||| ...|.                                  |...||
iatqgPl.........................pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrt

IEITSNFsksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQ
.|.|..     .|..|..|. |.||  .. |.   ..|. ...|||       .. |||||| |.||...|.  .|... .  .       |.|. ....
leltnlg...tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg......gvdvleavk

DLRSMRAGAIYTPMQLAFSIIMLLDFV
 |||.| |...|| |. | . .||...
llrsqRpgmvqtpeqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 2-188 2.2e-29 98.3 In-house 104-290 (297) alignment
Range on Protein: 2-188
Range on HMM: 104-290/297.0
ILTQGPIHWktlpksvddvdecaqgvepsrppysTMDKFLQMIVQTKATDVVMLGDFYEN-----------------------------DVVLRTIEITS
|.|||| .                          |...|..|. . . | .||| .. |.                             ....||.|.| 
IatqgPlpe.........................tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn

nfsksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtptVGLDYVKLIQDLRSM
     ..|..|..|. | ||   . |.... .|.....||       |.. |.|||| |.||...|.   |... .  .       |.|. . .. ||..
.....ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke......ggvdvleavkelreq

RAGAIYTPMQLAFSIIMLLDFVL
| ||. || |. | . .||....
Rpgavqtpsqyrflydallellk

0045450 (Phosphotyrosine protein) phosphatases II 2-188 3.9e-29 97.8 In-house 110-305 (307) alignment
Range on Protein: 2-188
Range on HMM: 110-305/307.0
ILTQGPIHWktlpksvddvdecaqgvepsrppysTMDKFLQMIVQTKATDVVMLGDFYEN--------------------------------DVVLRTIE
|.|||| .                          |...|..|. . . | .||| .. |.                                ....||.|
IatqgPlpe.........................tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtle

ITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQTPtvgLDYVKLIQDL
.| .  . ..|..|..|..|.||  .. |.   |.|. ...||       |.. |.|||| |.||...|.   |... .  .   .    .|. . .. |
vtdl..dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlld...vdlleavkll

RSMRAGAIYTPMQLAFSIIMLLDFVL
|..| ||. .| |. | . .||...|
reqRpgavqnpeqyrflyeallelll

0040439 (Phosphotyrosine protein) phosphatases II 2-188 3.6e-27 91.0 In-house 57-247 (249) alignment
Range on Protein: 2-188
Range on HMM: 57-247/249.0
ILTQGPIHWktlpksvddvdecaqgvepsrppysTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEI
|.|||| .                          |...|..|. . . | .||| .. |.                               |...||.|.
iatqgPlpe.........................tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

TSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtptVGLDYVKLIQDLR
| .    ..|..|..|. | .|  .. |.   ..|. ..||||       .. |.|||| |.||...|.   |... .  .       |.|.   ...||
tnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke......lgvdleeavkllr

SMRAGAIYTPMQLAFSIIMLLDFVL
|.| ||...| |. | . .||...|
sqRpgavqnpeqyrflyeallelll

0045098 (Phosphotyrosine protein) phosphatases II 2-188 1.8e-26 88.6 In-house 67-273 (278) alignment
Range on Protein: 2-188
Range on HMM: 67-273/278.0
ILTQGPIHwktlpksvddvdecaqgvepsrppySTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEI
|.||||                           ||...|..|. . . | .||| ...|.                               |..|||...
IatqgPlp.........................stvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllv

TS-NFSKSKKETHTIRHYFYKGWIAQNGPELS--REILNVFKAVR------------------KSKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmrqtp
|  .. ..  |.....|. |..|   . |.|.  . .|.... .|                  ... |.|||| |.||.....   | .. .        
tnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell........

TVGLDYVKLIQDLRSMRAG-AIYTPMQLAFSIIMLLDFVL
  |.|. . .. |||.| | |. ...|. | . .||...|
eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0051299 (Phosphotyrosine protein) phosphatases II 3-187 2.7e-30 101.2 In-house 96-286 (288) alignment
Range on Protein: 3-187
Range on HMM: 96-286/288.0
LTQGPIHwktlpksvddvdecaqgvepsrppySTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEIT
.|||| .                         .|...| .|. . . . .||| ...|.                               |...||.|.|
atqgPlp.........................ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevt

SN-FSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSM
 . . . ..|..|..|. |..|  .. |.  ...|.  ..|||.     . |||||| |.||...|.  .|... .  .       |.|. .... ||..
nldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeg......gvdvleavkrlreq

RAGAIYTPMQLAFSIIMLLDFV
| |.. ||.|. | . .||...
Rpgmvqtpeqyrfvyealleyl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 3-62 4e-21 70.2 In-house 1-66 (255) alignment
Range on Protein: 3-62
Range on HMM: 1-66/255.0
LTQGPIHWKTLPKSVDDVDECAQGVEPSRPP-----YS-TMDKFLQMIVQTKATDVVMLGDFYEND
|..|....|.||....|.|.|...|.|....     || |.|||.|.|||||...||||.||.|..
ldkGalkfkklPrilidedvctehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeeg

0042113 (Phosphotyrosine protein) phosphatases II 30-186 4.1e-27 90.6 In-house 63-242 (245) alignment
Range on Protein: 30-186
Range on HMM: 63-242/245.0
SrppysTMDKFLQMIVQTKATDVVMLGDFYEND-------------------------------VVLRTIEITSNfskSKKETHTIRHYFYKGWIAQNGP
.     | ..|..|. . . | .||| .. |..                               ...||.|.| .    ..|.....||.| .|  .. |
e.....tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnl...gddesrevihyhylpwpdhgvp

ELSREILNVFKAVRK------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDF
.|.. .|.....|||      .. |.|||| |.||...|.   |... .  ..      |..  . ...|||.| ||. || |. | . .||..
dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekel......gvsleeavkelrsqRpgavqtpsqyrflyeallel

0041856 (Phosphotyrosine protein) phosphatases II 30-190 8.8e-20 66.5 In-house 40-174 (182) alignment
Range on Protein: 30-190
Range on HMM: 40-174/182.0
SRPPYSTMDKFLQMIVQTKATDVVMLGDFYENDvvlrtieitsnfsksKKETHTIRHYFYKGWIAQNGPElSREILNVFKAVRKS-KSVVVHCSTGIGRA
 .|..||. .||.|. . . | .|.| ... .                ....... .|.| .|   . |.  .|.|.  ..|... . |.|||| |.||.
qgpllstvadflrmlkelgittivnlteelywp...............ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRt

AAFAFTELAYQTmmlnmrqtptvGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLEN
....   | ..            |... . .. .||.| |.. || |. |   .||...| .
gtlvaaylmkkl...........gvsleeavklvrsrRpgmvitpnqyfflqlallellllk

0046845 (Phosphotyrosine protein) phosphatases II 31-188 1.5e-30 102.0 In-house 84-275 (284) alignment
Range on Protein: 31-188
Range on HMM: 84-275/284.0
RPPYSTMDKFLQMIVQTKATDVVMLGDFYEND--------------------------------VVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGP
 |  .|...| .|. . ... .||| .. ||.                                ...||.|.| .  . ..|..|..|. |..|  .. |
gPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvp

ELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtPTVGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVL
. .. .|. ...||.       .. .||||| |.||...|.  .|... .  .    ...|.|. .... ||..| |.. |..|. | . .||....
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeg...lllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0043336 (Phosphotyrosine protein) phosphatases II 31-186 9.7e-28 92.8 In-house 95-276 (278) alignment
Range on Protein: 31-186
Range on HMM: 95-276/278.0
RPPYSTMDKFLQMIVQTKATDVVMLGDFYEND------------------------------VVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPEL
 |  .|...| .|. . . | .||| .. |..                              ...||.|.|    . ..|..|..|| |.||  .. || 
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpes

SREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDF
   .|.  ||||.     .. |.|||| |.||...|.  .|... .. .       |.|. . ...||..|.||. ||.|. | . .||..
lsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg......gvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 31-197 9.6e-11 35.7 In-house 95-242 (392) alignment
Range on Protein: 31-197
Range on HMM: 95-242/392.0
RPPYSTMDKFLQMIVQTKATDVVMLGDFYENDvvlrtieitsnfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGI
 |  ...| | .|. | ..| ..|. .. | |                ....|.  ...  |  .. |. .  .|.. | |.      .. ...|||.|.
gpnaaslddfwrmvfqenvttiamvtklkegd..............kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagv

GRAAAFafteLAYQTMMLNMRQTPTVglDYVKLIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETN
||..      .. ....   ..|  |  | .... ..|  |   . |  | ||    .   |||. | ..| 
grtgvv....isidsvvahakktrmv..dvfnfvtnirrkrpymvqtkeqyaf....iygavledllwrntl

0037934 (Phosphotyrosine protein) phosphatases II 32-183 2.6e-24 81.5 In-house 52-238 (243) alignment
Range on Protein: 32-183
Range on HMM: 52-238/243.0
PPYSTMDK----FLQMIVQTKATDVVMLGDFYEN-----------------------------DVVLRTIEITSnfSKSKKETHTIRHYFYKGWIAQNGP
|  .| .     |..|. . . | .||| ...|.                             |...||....    . ...|....|| | .|  .. |
PlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen..ldlddltrlvihyhylpwpdhgvP

ELSREILNVFKAVRK-------------SKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmrqtptvGLDYVKLIQDLRSMRAG-AIYTPMQLAFSIIML
.    .|. ...||.             .. |.|||| |.||.....   | .. .          |.|. . ...||..| | |. || |. | . .|
dspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll..........gvdleeavkllreqRpgkavqtpsqyrflyeal

0043147 (Phosphotyrosine protein) phosphatases II 32-179 8.7e-21 69.8 In-house 28-153 (172) alignment
Range on Protein: 32-179
Range on HMM: 28-153/172.0
PPYSTMDKFLQMIVQTKATDVVMLGDFyendvvlrtieitsnFSKSKKETHTIRHYFYKGWIAQNGPeLSREILNVFKAVRK------SKSVVVHCSTGI
|  .|...|..|. . . | .|.| ..               .   ....... .| | .|  .. | |.. .|.... ...      .. |.|||| |.
plrntladfwrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGv

GRAAAFAFTELAYqtmmlnmrqtptVGLDYVKLIQDLRSMRAGAIYTPMQLAFS
||.....   | .             ||.. . .. .|..| ||...| |. | 
gRtgtlvaaylml............lglsleeavalvrekRpgavqnpsqyrfl

0049260 (Phosphotyrosine protein) phosphatases II 32-178 1.2e-18 62.7 In-house 17-141 (152) alignment
Range on Protein: 32-178
Range on HMM: 17-141/152.0
PPYSTMDKFLQMIVQTKATDVVMLGDFYENDVVLRTIEItsnfskskkethtirHYFYKGWIAQNGPELSREILNVFK-----AVRKSKSVVVHCSTGIG
|   |...|..|. . ..| .||| ...|.. .     |               .|..  |   . |.||  .| ...     | .|.. |.|||| |.|
pgpntladfwrmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

RAAAFAFTELAYqtmmlnmrqtptVGLDYVKLIQDLRSMRAGAIYTPMQLAF
|.....   | .             |... . .. .|..| ||...| || |
Rtgtlvaaylml............lgvsleeavalvrekRpgavpnpgqlrf

0046846 (Phosphotyrosine protein) phosphatases II 32-179 2.5e-17 58.7 In-house 31-165 (176) alignment
Range on Protein: 32-179
Range on HMM: 31-165/176.0
PPYSTMDKFLQMIVQTKATDVVMLGDFYENDVV--LRTIEITSN--FskskkethtirHYFYKGWIAQNGPELsREILNVFKAVRKSK----SVVVHCST
| ..|. .||.|. . . | ||.| . .| . .   .  ..  .  .           .|.. .|   . |.| . .|......|.       |.|||| 
plprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsa

GIGRAAAFAFTELAYQtmmlnmrqtpTVGLDYVKLIQDLRSMRA-GAIYTPMQLAFS
||||.....   | .             ||.. . .. .|..|  ||. || |. | 
GigRtgtlvaayllel..........ekglsveealalvreqRplgavqtpeQyrfl

0051429 (Phosphotyrosine protein) phosphatases II 32-189 5.7e-17 57.7 In-house 30-227 (272) alignment
Range on Protein: 32-189
Range on HMM: 30-227/272.0
PPYSTMDKFLQMiVQTKATDVVMLGDFYENDVVLRT----------------IEITSNFSK-------------------------SKKETHTIRHYFYK
|   | . | ..  . . . .|.| . .| . .                    . | .. .                         | .|.....|..| 
plpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhyt

GWIAQNGPELSreILNVFKAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmrqTPTVGLD--------YVKLIQDLRSMRAGAIYTPMQLAFSIIM
.|.  . |. .  .|.......... |.|||| |..| . ..   | .. .      . .. .|        . . .. ||..|.||. |..|..|    
dwpdhgvpqea..llellellldggpvlvHCsaGkdRTGtvvallllllgv......sletivddYlltnlyleeaveelraqrpgavqteeqylflyea

LLDFVLE
||... .
llellrs

0049772 (Phosphotyrosine protein) phosphatases II 32-186 5e-12 41.6 In-house 92-279 (314) alignment
Range on Protein: 32-186
Range on HMM: 92-279/314.0
PPYSTMDKF----------LQMIV--QTKATDVVM---------------------LGDFYENDvvlrT----------IeitSNFSKSKKETHTIRHYF
|   |.. |          ..|..  . .  |.||                     | .. .|                    .     .. .... .|.
pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk...eelydpelferlgikyl

YKGWIAqNGPELSREILNVFKAVR---KSKSVVVHCSTGIGRAAAFAFteLAYqtMMLNMrqtptvGLDYVKLIQDLRSMRA-----GAIYTPMQLAFSI
.  .   ... |.. .. ......   | . |.|||. |.||.. |..  .||  .|. .      |... . ..|.|..|      |.|....|. |  
ripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvv..aay..lmkll......gvsleealedvrlkRpinpnpgfieqleqyefil

IMLLDF
  ||..
ealley

0036282 (Phosphotyrosine protein) phosphatases II 35-178 1.3e-17 59.5 In-house 27-161 (174) alignment
Range on Protein: 35-178
Range on HMM: 27-161/174.0
StmdkFLQMIVQTKATDVVMLGDFYENDVVLRTI---EitsnfsKSKKETHTIRHYFYKGWIAQNGPELSReILNVFKAVRK------SKSVVVHCSTGI
.    |..|. . . |.|||| . .|.. ..      |      ... ..... .|.| .|   . |.||  .|...|.|..      .. |.|||| |.
a....fwemlkelgittvvmlleekelglykcinywpe......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGv

GRAAAFAFTELAYQTMMLNMRQTptvgldyVKLIQDLRSMRAGAIYTPMQLAF
||.....   | .. .. ....        ..|.. ||..| |...|| |. |
gRtGtlvaaylmlrglleslvda.......ldlvrelRlqrpgmvqtpsQyrf

0051082 (Phosphotyrosine protein) phosphatases II 37-181 4.6e-16 54.2 In-house 22-147 (151) alignment
Range on Protein: 37-181
Range on HMM: 22-147/151.0
MDKFLQMIVQTKATDVVMLGDFYENDvvlrtieitSNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK--SKSVVVHCSTGIGRAAAFAFT
.. ||... . . . .|.| . .|..          . .  ... ....|. . .| ... |..  ..|........  .. |.|||| |.|| ....  
ladflellkelgiktivnlrseeerg.........ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlval

ELAYQTmmlnmrqtptvgLDYVKLIQDLRSMRAGAIYTPMQLAFSII
 | ..             ... . ....|..| |......|  | ..
ylmllg............vsleealeeyrlkrpgvvqpnqqflfqlf

0044763 (Phosphotyrosine protein) phosphatases II 38-178 9.1e-14 47.0 In-house 38-162 (178) alignment
Range on Protein: 38-178
Range on HMM: 38-162/178.0
DKFLQMIVQTKATDVVMLGDFYENDVVLRTIEITSNFSkskkethtiRHYFYKGWIAQNGPELSREILNVFKAV-----RKSKSVVVHCSTGIGRAAAFA
 ..|... . . | .|.| . .|.  .    .  ....          .|.. ..   . |.|.. .|......     .| . |.|||| |.||.....
addlellkelgithivnlteelelgflkcdpywpeeag.........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlv

FTELAYQTmmlnmrqtptvGLDYVKLIQDLRSMRAgAIYTPMQLAF
   | ..            ||.. . |. .|..|  ....| || .
aaylmkkl...........glsleeaielvrerRp.ivpnpgqlrq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 51-218 4.1e-13 44.1 In-house 147-307 (318) alignment
Range on Protein: 51-218
Range on HMM: 147-307/318.0
DVVMLGDFYENDVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLN
 | .  ..  .| |||....|    . ..|. ..| | |  |  .. || . ..|.. . |.| .       .|||||.|.||.  |    .| ....  
vvelkeevelsdyvlrefkvtr...teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvf....iavdiller

MRQTPTVglDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVleneLSKETNIKYQQIRNSYLDLRKRKYRTS
...  .|  |  . .. ||. |   . |  |  |   .||...     | .|... ...|.   .||...  . 
ikaealv..Dvfqtvkqlreqrnlmvqtedqyefiydvlleal....asgdtevdasdlrsrirelreqdpesg

subfamily_PTPN9_pd Subfamily PTPN9 55-190 1.4e-10 35.7 In-house 149-293 (297) alignment
Range on Protein: 55-190
Range on HMM: 149-293/297.0
LGDFYENDVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------------------SVVVHCSTGIGRAAAFAftEL
. .  |.| . |..||.      ..|. .. |. . .|     |. . ..|.| ..||. .                   .|||||.||||. .|.   |
veveeeedykvrvleikn...vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfi..tl

AYQTMMLNMRQTptvgLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLEN
 .    |.. .|    .| |. .. ||. || .| || | .|  . .|.. ||.
diclsrleevgt....vdvvetvkllrtqrafsiqtpeqyefcylavleyalel

subfamily_PTPN12_pd Subfamily PTPN12 57-187 9.6e-15 49.2 In-house 150-277 (290) alignment
Range on Protein: 57-187
Range on HMM: 150-277/290.0
DFYENDVVLRTIEITSNfskskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAFteLAYQTMMLNMRQTPTv
.  ..| ..||.... .     ||..... . |. |  .. |.   ..|.. ..||.      . .||||| |.||. .     . |  ..|. ...|  
kavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiia..idyvrellkaekipe.

GLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 ||  .|...||  || .. |  |  .    ....|
eldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 59-187 4.9e-11 36.8 In-house 144-269 (281) alignment
Range on Protein: 59-187
Range on HMM: 144-269/281.0
YENDVVLRTIEITSNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-KSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqTPtvglDYVK
||.  | ...  |      . ||. | |...| |   . || |  .|.... .| .|   |.|||.|.||. ..   |.| |..   .   |    |  .
yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshft.lp....dikq

LIQDLRS-MRAGAIYTPMQLAFSIIMLLDFV
..  ||   || .. |  |  .   .|||| 
ivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 60-206 2.4e-22 74.4 In-house 140-278 (290) alignment
Range on Protein: 60-206
Range on HMM: 140-278/290.0
ENDVVLRTIEITsnFSksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQtptvgLDYVKL
|.||  |.....  |   ..| .|. |. .|||   | .| .. .|.. . |..||  |.|||  || | ||.|  .|.|| ..    .     .  ...
eddvetRelvvk..fd..deeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgs.....vkledv

IQDLRSMRAGAIYTPMQLAFSI--IMLLDFVLENELSKETNIkyQQIRNS
...||..|| || ....||| .  |.|| .   .. ..|...  ..... 
lkalrkqralaitsalelafvdagivllaievldqfaeeete..kkakae

Y_phosphatase Protein-tyrosine phosphatase 60-183 1.3e-20 69.2 Pfam-A 113-233 (235) alignment
Range on Protein: 60-183
Range on HMM: 113-233/235.0
ENDVVLRTIEITSNFSKSkkETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLD
|....||..|.... ..|  |....... |..|  .. || ....|.. ..|.|||     .||||||.|.||.. |.  ... . .  .        .|
ekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee......vd

YVKLIQDLRSMRAGAIYTPMQLAFSIIML
 ..... ||. |.|.. .  |..| . ..
vlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 60-183 1.3e-20 69.2 In-house 113-233 (235) alignment
Range on Protein: 60-183
Range on HMM: 113-233/235.0
ENDVVLRTIEITSNFSKSkkETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLD
|....||..|.... ..|  |....... |..|  .. || ....|.. ..|.|||     .||||||.|.||.. |.  ... . .  .        .|
ekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee......vd

YVKLIQDLRSMRAGAIYTPMQLAFSIIML
 ..... ||. |.|.. .  |..| . ..
vlqivkelRkqRpgmvqsleqYiflykai

subfamily_PTPRK_pd Subfamily PTPRK 60-217 6.8e-17 56.3 In-house 152-303 (314) alignment
Range on Protein: 60-217
Range on HMM: 152-303/314.0
ENDVVLRTIEITsNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTelayqTMMLNMRQTPTVgLD
....| |.  .. . .....|....|.. . || . . |   . .|.. . | ||.      .|||||.| ||. .|        ...|.| ..  | .|
laelvvrifrve.klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiai.....divldmieregv.vd

YVKLIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETNIKYQQIRNSYLDLRKRKYRT
  . ...||| .   . |  |  |    . | .||  |  || |   .... ||.  .   .|
vfnavktlrsrkvnmveteeqykf....iydvileaclcgetaipvsefkalylesirldpqt

subfamily_PTPN6_pd Subfamily PTPN6 60-187 1e-13 46.0 In-house 166-297 (306) alignment
Range on Protein: 60-187
Range on HMM: 166-297/306.0
ENDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS---------KSVVVHCSTGIGRAAAFAFTELAYQTMMlnmRQTPT
 .| .||.. .. .  |.|||......| .| |  .. |.    .|. .. |..           ..||||| ||||  .|  ...  ....   ..   
ladYilRelsvskk..kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie...kkgld

VGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
. .|  ||.. .|. | | . |  |  |   ..  ..
adidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 60-186 2.1e-12 42.2 In-house 129-257 (284) alignment
Range on Protein: 60-186
Range on HMM: 129-257/284.0
ENDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVg
 .. |.| ||.. .    .|.  .|| . ..||  .  |. . ... . | ||       . ...|||||.|.||. ..    .. ....  |..   | 
seeyvvrdielsed..gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy....ivldvlldrmkeekqv.

lDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLD---F
 |  ....|||  |   .   .|  |  . ||.   |
.dvynfvrdlrqqrntlvqdlvqykfiysalleehlf

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 60-185 2.2e-12 41.9 In-house 165-289 (319) alignment
Range on Protein: 60-185
Range on HMM: 165-289/319.0
ENDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVg
 .. |.| ||.. .    .|.   |. . ..||  .  |. . ... . | ||       . ...|||||.|.||. ..    .. ....  |..   | 
taeyvvrdielsed..gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy....ivldvlldrmkeekqv.

lDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLD
 |  ....|||  |   .   .|  |  . ||.
.dvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN13_pd Subfamily PTPN13 60-180 1.4e-10 35.9 In-house 147-262 (273) alignment
Range on Protein: 60-180
Range on HMM: 147-262/273.0
ENDVVLRTIEITSNFSkskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS----VVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDY
 .. |.|..... . |   .|.. . |  .  |   . |  . |.|.. . ||. ..    .|||||.||||. ..   . . . .  .        .| 
ldgfvvralavkdses...gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk......efdv

VKLIQDLRSMRAGAIYTPMQLAFSI
 .....||  | | . |  |  |  
keivrklreqrqgvvqtkdqyifvy

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 60-183 2.4e-09 31.6 In-house 153-274 (287) alignment
Range on Protein: 60-183
Range on HMM: 153-274/287.0
ENDVVLRTIEITSNFSksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAV----RK--SKSVVVHCSTGIGRAAAFAFTElayqtMMLNMRQTPTvGL
..... |..|.. . .  ........ | .  |  .   .  . || |..      ||    |.||||| ..||.| |   .     . .|  .|   ..
nagyierklevknknk..agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaa.....ttinkckteG.vi

DYVKLIQDLRSMRAGAIYTPMQLAFSIIML
| .....  |  . |.. |  |  | . ..
Dvfqvlksqriqkpgsvqtveqykfindiv

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 60-178 2.2e-07 25.2 In-house 138-250 (267) alignment
Range on Protein: 60-178
Range on HMM: 138-250/267.0
ENDVVLRTIEItsNFskSKKETHTIRHYFYKGWI--AQNGPELSR--EILNVFKAVRKSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTvgLDY
|||  . |.|.  .|   .. .| .  |.|| |   ..| | |     ||   .    .. .||.|| |.||. .|    |  ....  ...  .  .| 
endyqiitlel..kf..knesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf....lvidsqleraktegv..sdi

VKLIQDLRSMRAGAIYTPMQLAF
 .... .|| | | . |  .  .
fdflrkirsqriglvdtkeryiy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 61-216 4.2e-74 243.8 In-house 96-247 (255) alignment
Range on Protein: 61-216
Range on HMM: 96-247/255.0
NDVVLRTIEITSNFSKsKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQTPTVGLDYVKLIQ
.||||||.||||.... ||.|||..||.|||||..|.|||.|||||..|.||.||||||||||||||.|||...||.||.|......|.||.|||..|..
advvlrtleitstlge.kkkthtvkhysykGWieknaPelareilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslle

DLRSMRAGAIYTPMQLAFSIIMLLDFVlenELSKETNIKYQQIRNSYLDLRKRKYR
.|||.|..||.||.||||||.|.||.|      .| . |||.||.|||  |.  ..
elrskrkraihtPlqlafsilmvldlv...fpkgeleakyqeirksylharqmmhk

DSPc_SM00195 61-187 1.3e-22 75.7 In-house 140-262 (263) alignment
Range on Protein: 61-187
Range on HMM: 140-262/263.0
NDVVLRTIEITSNFSkskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-----VVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLDY
....|||.|.| .     .||.....| ||.|  .. |.  ...|....||.||||     .|||||.|.||...|. ...... .  . .      .| 
deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk......vdi

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 .... ||. |.|.. | .|..| . ..|...
feivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 61-187 1.3e-22 75.7 In-house 140-262 (263) alignment
Range on Protein: 61-187
Range on HMM: 140-262/263.0
NDVVLRTIEITSNFSkskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-----VVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLDY
....|||.|.| .     .||.....| ||.|  .. |.  ...|....||.||||     .|||||.|.||...|. ...... .  . .      .| 
deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk......vdi

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 .... ||. |.|.. | .|..| . ..|...
feivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 61-221 6.1e-17 56.6 In-house 159-313 (319) alignment
Range on Protein: 61-221
Range on HMM: 159-313/319.0
NDVVLRTIEItsNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS------VVVHCSTGIGRAAAFAftelAYQTMMLNMRQTPTvgLD
.|.. | ...  |  .|. || .. |. |. |  .. || .. .|...| .|||..      .||||| |.||  .|     . . |. ....  .  ||
edyiirklkl..nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi....vldamlervkeegv..lD

YVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVleneLSKETNIKYQQIRNSYLDLRKRKYRTSEEY
  . .. ||  |   . .| |  |    ||..|     . .|.|. |..|.   .|....  | | .
vfstvsrlRtqRnimvqrpeqYkfiyealleav....eagdteievqdlrdrlkqlaekvadtgetg

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 61-189 3.6e-13 43.8 In-house 165-285 (290) alignment
Range on Protein: 61-189
Range on HMM: 165-285/290.0
NDVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-KSVVVHCSTGIGRAAAFAFTELAYQTMmLNMRQtptvgLDYVKLI
......|. .     | .   | ..|.  | |  .  .  .  .| .....||    ||||||.||||. .|.  | . | . |. ..     || ..|.
aniikktlsvrd...kdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqil.ldGke.....ldlldlv

QDLRSMRAGAIYTPMQLAFSIIMLLDFVLE
. ||  |....   .|    . .|||.  .
ralrnsrlnsvqvdiqylalveilldlGkd

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 61-202 4.2e-12 40.8 In-house 159-294 (305) alignment
Range on Protein: 61-202
Range on HMM: 159-294/305.0
NDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS------KSVVVHCSTGIGRAAAFAFTElayqTMMLNMRQTPTVglD
.| . | ..|. .  ...||..|. .|    |  .  |. .  .|...| |.|.      ....|||| |.||. .|   .     ..  ...  .|  |
sdyieRklkisie..dedkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavd....ialerlkkEevv..d

YVKLIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETNIKYQQ
  .... ||| | ... |  |  |    | | . |   . .|.|  . 
vfevlkqlRskrmkmvqtldqYvf....lhdaldelitcgdtsiigsn

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 61-187 2.8e-11 37.8 In-house 159-283 (290) alignment
Range on Protein: 61-187
Range on HMM: 159-283/290.0
NDVVLRTIEITSNFSKskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK------SKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmRQtpTVGLD
|. . |..|.... |.  ...... .|  . |  .   .    || |.. . |       .|.||||| ..||.| |  .. . . .    ..  . . |
neyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkc....kt..egvid

YVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 ..... .|. . | . |  |. . . ..|  .
vfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Ptp69D_pd Subfamily Ptp69D 61-188 3.9e-11 37.6 In-house 159-287 (307) alignment
Range on Protein: 61-188
Range on HMM: 159-287/307.0
NDVVLRTIEITSNFSKS--KKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR----KSK-SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVgl
.| . |..... .  .|   .... .  | |.||   . || .| .|.. . ||    ...  .|||||.| ||.. |    .| . .. ....  .|  
sdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif....valdsllqqlkaedkv..

DYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVL
| .. ..|||| |   .    |  |    |||.  
difetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 61-206 4.7e-08 27.5 In-house 160-303 (325) alignment
Range on Protein: 61-206
Range on HMM: 160-303/325.0
NDVVLRTIEITSnfsKSKKETHTIRHYFYKGWI---AQNGPELSREILNVFKAV----RK----SKSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTP
 | | | ...      .| || ... . ...|     |. |     ||.. |||    .     |  ..||||.|.||. .|.    .  ... .. .  
sdyvhrvldvkq...vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfi....slysalakviees

TVglDYVKLIQDLRSMRAGAIYTPMQLafsiIMLLDFVLENELSKETNIKYQQIRNS
 |  |  . .. ||  |   . |  |     |.. . . |  .| .|..    .   
rv..difgfvkklrkdrpsmvetvdqy....iliyealveaymsgntdvpvssfeak

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 62-180 8.1e-16 52.6 In-house 163-274 (301) alignment
Range on Protein: 62-180
Range on HMM: 163-274/301.0
DVVLRTIEITSnfSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTELayqtMMLNMRQTPTVGLDyvKLIQ
... ||.|..   |  | .|.|. || |. | ... |.   |. .. . |.||.  .|||||.||||. ||  ||     .  ..   ||. |   . ..
kiskrtleved..stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigtey....lareveadptielt..ealk

DLRSMRAGAIYTPMQLAFSI
.||  |  .. |  || .  
hlrehrwngvqtnsqlywmt

subfamily_PTPRD_pd Subfamily PTPRD 62-220 1e-15 52.5 In-house 160-310 (564) alignment
Range on Protein: 62-220
Range on HMM: 160-310/564.0
DVVLRTIEItSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYV
|...||... ..  |...|....|.. .  |  .. ||  ...|.. . ||..     . .||||| |.||  .|    .. . |.  ...  ||  |  
dyeirtfkl.kk..kkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtf....ividamlerikeektv..Diy

KLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVleneLSKETNIKYQQIRNSYLDLRKRKYRTSEE
. .. ||. |   . |. | .|   ..|...     . .|... .....    |.. .  |.  
qyvkalrkqRnamVqteeQYiFiheaileal....acgntevesenlkqhlqkLaeveedtemt

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 62-187 4.8e-14 47.1 In-house 160-279 (288) alignment
Range on Protein: 62-187
Range on HMM: 160-279/288.0
DVVLRTIEITsnfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQtpTVGLDYV
|.|||....       ||.  .| .| |..|  .. || ....|.. . |       .. ..|||| |.||.  |    .| .... ....  .  .| .
dfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtF....ialdalidavee..edyiDva

KLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
  .. ||  ||  . |  |  |   .||. .
gtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 62-185 1.4e-12 42.4 In-house 168-288 (298) alignment
Range on Protein: 62-185
Range on HMM: 168-288/298.0
DVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS------KSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTPTVglDY
|.. |......   |........|.  .  |  .  || .. .|.. . ||.|      |.|.|.|| |.||. .|     | ....  ...  .|  | 
dlivrklkvsk...kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi....aidsvlervkkeqvv..Dv

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLD
 . .. ||  |.||. |  | .|   . |.
fqvvkvlRkkrpgavqteeqYvfiyeavle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 62-185 3.7e-12 41.0 In-house 120-240 (250) alignment
Range on Protein: 62-185
Range on HMM: 120-240/250.0
DVVLRTIEITSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDY
|.. |.. ....   .|..  ..|.. .  |  .  ||  . .|.. | |..|.       |.|.||.|.||. ||    .| .... ....  .|  | 
dytkrklklska...kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf....iaidavlerlkkekvv..dv

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLD
 |.|. ||  | .|. .  |  |   ..| 
fkvikvlrkdrphavesleqyvfvyeiilk

subfamily_PTPRA_pd Subfamily PTPRA 62-193 4.8e-12 40.4 In-house 170-303 (330) alignment
Range on Protein: 62-193
Range on HMM: 170-303/330.0
DVVLRTIEITSNFS-KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTvgLDY
|. .| . ..     . .|..  .| . ...|     |  .. .|...|.|.| .     ..|||||.|.||. .|    .. ....  ..      .| 
dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtf....ivldavlervkaerk..vdv

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLENE--LS
 . .. ||  |.  . | .|  |   .||.. |  .  | 
fefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld

subfamily_PTPN3_pd Subfamily PTPN3 62-178 5.5e-12 40.2 In-house 154-266 (280) alignment
Range on Protein: 62-178
Range on HMM: 154-266/280.0
DVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTELAYQtmmLNMRQTPTVGLDYV
 .||| . ..    |..|| ..| .  |  |  .. |. | ..|.. . ||| .      ||||||.||||.  . . |.| .   |  .. |   || |
syvlrelvlkd...ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala...lieaaepvypldiv

KLIQDlrsMRAGAIYTPMQLAF
. ..|    ||  . |. |  |
rtmrd...qramlvqtasqykf

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 62-189 1.5e-11 38.3 In-house 169-290 (302) alignment
Range on Protein: 62-189
Range on HMM: 169-290/302.0
DVVLRTIEITSNFSKSkKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-KSVVVHCSTGIGRAAAFAftELAYQTMMLNMRQTpTvglDYVKLIQ
...| |.||. .  |. |  .|.    . .|     |. .   |...|      |.|.||||.|.||. ..    . |   .   ... |   | .....
sfklytveiknekkkk.kvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlv..aikyGiqlcskkkv.t...dllsivl

DLRSMRAGAIYTPMQLAFSIIMLLDFVLE
 .|. | ||. .  || . ....   ..|
pvrqcryGavqdeqqliylllcvtkglme

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 62-164 5.2e-06 20.8 In-house 119-220 (239) alignment
Range on Protein: 62-164
Range on HMM: 119-220/239.0
DVVLRTIEItSNFskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVG-LDY
| ..||. . |.    . | . . .|..  |  .  |. .  .| . . . |     ..  |.|||.|.||. ||    |  ..|. . ..  ||  ..|
dyiirtfvm.sqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf....lvidamlrqakkqktvdifny

VKLIQDLRS
|| |.. | 
vkairedrp

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 62-164 5.7e-06 20.7 In-house 120-221 (239) alignment
Range on Protein: 62-164
Range on HMM: 120-221/239.0
DVVLRTIEItSNFskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVG-LDY
| ..||. . |.    . | . . .|..  |  .  |. .  .| . . . |     ..  |.|||.|.||. ||    |  ..|. . ..  ||  ..|
dyiirtfvm.sqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf....lvidamlrqakkqktvdifny

VKLIQDLRS
|| |.. | 
vkairedrp

subfamily_PTPRB_pd Subfamily PTPRB 63-188 2.5e-13 44.8 In-house 165-286 (293) alignment
Range on Protein: 63-188
Range on HMM: 165-286/293.0
VVLRTIEITSnfsksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDY
 |.|...|.      .||....|.| .. |   . || .. .|. ...||...        .||||| |.||. .|    .| .... ..... .|  | 
wvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtf....ialdrllqaieeedyv..di

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVL
. ....||. |.  . |  |  |    .||.. 
fgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 64-146 8.9e-07 22.7 In-house 157-244 (439) alignment
Range on Protein: 64-146
Range on HMM: 157-244/439.0
VLRTIEITSNFSKSKKEtHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS------KSVVVHCSTGIGRAAAFAFTELAYQTMMLNMR
|.| . .  .  ...|| .|. .. |  |  .| |  .  .|. ..|.  .        ||||||.|.||. .    ..| . . |. .
virgfkvfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenk

subfamily_PTPRG_pd Subfamily PTPRG 66-206 1.3e-10 35.2 In-house 164-307 (563) alignment
Range on Protein: 66-206
Range on HMM: 164-307/563.0
RTIEITSNFSKSKK---ETHTIRHYFYKGWIAQNGPELSREILNVF-KAVRKSKS----VVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYVK
||. |     | ||   . ...|.| |  |  .. || |   |.   |. .  |.    .|||||.|.||.  .    .. .|.. ...|  .|  .  .
rtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGty....ivldtllkqiqqenav..nvfg

LIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETNIKYQQIRN-----S
... .|..|   . |  |  |    | | .||  .||||... .|...      
flkhiraqRnflvqteEqYif....lhdalleaiasketellaeqveelknctp

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 66-189 2.9e-09 31.4 In-house 154-273 (288) alignment
Range on Protein: 66-189
Range on HMM: 154-273/288.0
RTIEITSNFS-KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtPTVGLdyVKLIQDLR
......     |  .|.  ...  .. |  .  ||     |.. . ...  | .|||.|.|.||....... .| ... |.      .|.   .|.. ||
klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrld....dflgi..rsllaklr

SMRAGAIYTPMQLAFSIIMLLDFVLE
  |  || | ||  .   ..|. .| 
eerfkaiqtemqylyvhrcvleelll

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 66-193 6.6e-08 27.0 In-house 164-290 (297) alignment
Range on Protein: 66-193
Range on HMM: 164-290/297.0
RTIEITSNfskSKKETHTIRHYFYKGWIAQNGPE--LSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYVK
|..|.| .   . | .. .. | .  |  .. ..    . .|.. . |||.        ..|||..|.||.. .    |. . .. ..... .|  |  .
relevtkg...kakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl....ltidsvvaeakrekev..difg

LIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLENELS
|.. ||  |   . |  | .|   ..|...| ..  
lvkklrqerpylvqtkeqykfvyvavleallsedtr

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 70-194 4.5e-12 40.2 In-house 175-296 (305) alignment
Range on Protein: 70-194
Range on HMM: 175-296/305.0
IT-SNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTELAYQTMMLNmRQTPTVgldyVKLIQDLRSMRA
||  |.. | ... ..||  .  |  .  |      |... |.| ||  .|||||.||||. .    |   . .  | .. | .     .|.. ||  ||
itllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaen.kpcppm....pelvkalrdqra

GAIYTPMQLAFSIIMLLDFVLENELSK
 .| . .|  |   ..|...||.   |
fsiqndvqylfihrvmlnyflekykek

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 70-187 3.9e-11 37.6 In-house 158-276 (281) alignment
Range on Protein: 70-187
Range on HMM: 158-276/281.0
ITSNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR------KSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTpTVGLDYVKLIQDLR
 . . .... || ....  |. |  .  |. ..|.|.  |.|.      .  ..|.|||.|.||. ..    .|  ... .. .. .  ||   ....||
rkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGty....ialDrlvkaveae.leeldvkavvaelr

SMRAGAIYTPMQLAFSIIMLLDFV
  |   . | .| .|   ..|| .
kernlmvqtvvqyefvykavldal

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 70-204 5.6e-10 33.6 In-house 150-279 (283) alignment
Range on Protein: 70-204
Range on HMM: 150-279/283.0
ITSNFSKSKKETHTIRHYFYKGWIAQNGPELSREI--LNVFKAV-RKS--KSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTpTVgLDYVKLIQDLRS
.. . . | |.|  . || . .|.  .       .  .|  ..  ..|    .||||||||||.|.|     |  . . ...   .| .|  . .. .| 
lllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi....aasasvkdalte.sv.vdvfavvkimre

MRAGAIYTPMQLafsiIMLLDFVLENELSKETNIKYQQIR
 | .|. |  |      .. . |||. |  .|.| . .. 
qrmmavqtldqy....klvhelvleqalcgdtqiaavdlq

0048076 (Phosphotyrosine protein) phosphatases II 74-178 5.4e-15 50.8 In-house 37-134 (145) alignment
Range on Protein: 74-178
Range on HMM: 37-134/145.0
FSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK----SKSVVVHCSTGIGRAAAFAFTELAYQtmmlnmrqtptVGLDYVKLIQDLRSMRAGA
 |  . ..... .|.| .|   . |.|.. .|........     . |.|||| |.||.....   | ..            |... . .. .||.| ||
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll...........lgvsleealelvrsqrpga

IYTPMQLAF
...| || |
vpnpgqlrf

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 75-199 9.4e-15 49.4 In-house 169-287 (307) alignment
Range on Protein: 75-199
Range on HMM: 169-287/307.0
SKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-KSVVVHCSTGIGRAAAFAFTELAYQTMMlnmrQTpTVGLDYVKLIQDLRSMRAGAIYTP
 .  ... ||.|. .. |  .  |..    .|...|||     ||||||.|.||. .     |  . |.    .      |  ||...||| |  || | 
vdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmi....aG.inckdmkklveelrsqrhyaiqte

MQLAFSIIMLLDFVLEneLSKETNIK
.|  .   .||.. ||  | |||  .
aqylylhrvlleyfle..lyketyee

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 75-195 5.9e-13 43.4 In-house 160-278 (285) alignment
Range on Protein: 75-195
Range on HMM: 160-278/285.0
SKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK----SKSVVVHCSTGIGRAAAFAftELAYQTMMLnMrQTPTVglDYVKLIQDLRSMRAGAI
  .  |   . |     |  |  || .| .....| |.|     | ..||||.|.||.|.|    . | |. . | . | .  . . .....|.||  |.
edasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfv..gidyatiri.m.enpni..emldivremramrfqav

YTPMQLAFSIIMLLDFVLENELSKE
 . ||. |  ..|..... . . . 
qshmqflflyvvlmeyfigegvver

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 75-196 3.7e-07 24.0 In-house 169-288 (303) alignment
Range on Protein: 75-196
Range on HMM: 169-288/303.0
SKSKKETHTIRHYFYkGWIAQN-GPELSREILNVFKAVRK---SKSVVVHCSTGIGRAAAFAFTELAYqtMMLNMRQTptvGLDYVKLIQDLRSMRAGAI
 ||    |  . . . . |  .  |.. ..| ..   .||   |.  |    .| ||| .||. | |.  . |   |.    || || .. .|  |  |.
yksflhvhhykawph.nsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah..lslhseqa...sldlvkclenvrngrlhav

YTPMQLAFSIIMLLDFVLENELSKET
    |...   .| . ||.| ..| .
qnlsqfsvvytllaehvldngickla

subfamily_PTPN1_pd Subfamily PTPN1 76-186 1.3e-15 51.9 In-house 156-270 (290) alignment
Range on Protein: 76-186
Range on HMM: 156-270/290.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-------VVVHCSTGIGRAAAFAFTElayqTMMLNMRQTPT-VGLDYVKLIQDLRSMRA
.. .||..| |. |  |     ||     |. .  ||.| |       .|.|||.||||. .|.. .    |..... ..    ..|  | . .||..| 
lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvd....tclvliekkddlssvdikkvllelrkyrl

GAIYTPMQLAFSIIMLLDF
| | |. || || . .|. 
GliqtadqlrfsylaileG

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 76-178 7.7e-13 43.1 In-house 155-259 (274) alignment
Range on Protein: 76-178
Range on HMM: 155-259/274.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK--------SVVVHCSTGIGRAAAFAFTELAYQtmmlNMRQTPTVglDYVKLIQDLRSMRA
|. ...... ||.|  |  .. |.  ...|.. . |..|.        .|||||| ||||. .|  ...| .    ..|.. .|  | .|.. .||  | 
kylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr....qlreeivv..dvlkivcnlrldrG

GAIYTPMQLAF
| . |  |  .
Gmvqtseqyel

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 76-209 6.6e-08 26.8 In-house 167-295 (315) alignment
Range on Protein: 76-209
Range on HMM: 167-295/315.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTPTVglDYVKLIQDLRSMRAGAI
.  .|..|.  . ...|  .  .. .  .|.. |.|. .      |..||||.|.||.  .     . . .. ....| .|  |  .... ||. |   .
rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi....sidevvaqikrtrsv..dvfnfvknlrakrpylv

YTPMQLAFsiimLLDFVLENELSKETNIKYQQIRNSYLD
 |  . ||    . | |||. | ..| |.  .. .   |
qteeeyaf....iydavledllwrntlilvihftdhlqd

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 76-198 7.9e-08 25.8 In-house 167-283 (515) alignment
Range on Protein: 76-198
Range on HMM: 167-283/515.0
KSKKeTHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYVKLIQDLRSMRAGAI
|... ..|.  . ...|  .  |. .. .| . |.|. ..     ....|||.|.||.  .    .. . .. ....| .|  |  .... .|  |   .
kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv....isidsvvahakttrmv..dvfnfvtnirqkrpylv

YTPMQLAFsiimLLDFVLENELSKETNI
 |  | ||    . . |||. | ..| |
qtqeqyaf....iygavledllwrntli

subfamily_PTPN23_pd Subfamily PTPN23 76-184 6.3e-07 23.5 In-house 165-277 (288) alignment
Range on Protein: 76-184
Range on HMM: 165-277/288.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK---------SKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmRQT---PtvglDYVKLIQDLR
..........|  .. |     |.   ..|.....|..          . .|||||.|.||. .||    | . .    ..    .    | ..... ||
ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel....ekgngll....diiqvvsrlr

SMRAGAIYTPMQLAFSIIMLL
  |   . .  || ||  . |
eqRrfmvqekeqlkfsyeavl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 76-190 4e-06 21.0 In-house 169-282 (315) alignment
Range on Protein: 76-190
Range on HMM: 169-282/315.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAftELayQTmMLNMRQTPTvGLDYVKLIQDLRSMRAGAI
 .... ...  . |  |   . |. .  ..|... |..       ..||||| |.||. .|    |  .. .|.  ..    .|  ..|. .|..| ...
vfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfi..tl..da.vldqaeaen.aidvynfitgvrqnrikmv

YTPMQLAFSIIMLLDFVLEN
 .  |  |   .||. ..  
qvaeqyqfiydalletfvcg

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 77-196 9.5e-12 39.2 In-house 181-296 (305) alignment
Range on Protein: 77-196
Range on HMM: 181-296/305.0
SKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-VVVHCSTGIGRAAAFAFTELAYQTMmLNMRQTPtvglDYVKLIQDLRSMRAGAIYTPMQ
. .... . || .  |  .  |     ||....  | ||  .|||||.||||. .  . |   . . |. ..      |  |..| .|  |  .| |  |
pgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildql.lagqiie....dtdkilqkireqrnnsiqtdaq

LAFSIIMLLDFVLENELSKET
  |   ..|.......| .|.
ylfvhqvilnyfrkkklldee

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 77-183 1.1e-11 39.2 In-house 147-260 (270) alignment
Range on Protein: 77-183
Range on HMM: 147-260/270.0
SKKETHTIRHYFYKGWIAQNGPE------LSREILNVFKAVRKSK-------SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLDYVKLIQDLR
.| |.. . |..|. |  .  |.       ....|....|||.|.        ..|||| |.||.  .  .. | ...  ...      .| ...|..||
ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkk......vdvlaiieelR

SMRAGAIYTPMQLAFSIIML
  |   . .| | .|    .
kdRmalvqhpeqyeflykav

subfamily_PTPRN_pd Subfamily PTPRN 78-182 1.1e-10 35.7 In-house 183-287 (297) alignment
Range on Protein: 78-182
Range on HMM: 183-287/297.0
KKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQtptvgLDYVKLIQDLRSMRAGAIYT
..|| |.  . .  | ... |  .. .|.  . | |     | ..||||| | ||. ..   .|  . ..  ...     .| .  .. ||  |.| . |
tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvke.....idiaatlehlrdqrpglvkt

PMQLAFSIIM
  |. | .  
kdqfefalta

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 78-203 1.7e-08 28.2 In-house 85-206 (440) alignment
Range on Protein: 78-203
Range on HMM: 85-206/440.0
KKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTvgLDYVKLIQDLRSMRAGAIY
  |..|...|.|.||  .  |...  .|.. . | .|.       ..||||.| ||..      .| .... . ...    .| . .|. .|. |   . 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgvi....iavdsilreakrsdq..idifsfinsmrnnrpqmvq

TPMQLAFSIimllDFVLENELSKETNIKYQQI
|| | ||      . |||  |. .| |  ..|
tpeqyafvh....eavlegllcgdtlileddi

0048179 (Phosphotyrosine protein) phosphatases II 79-178 8e-14 47.1 In-house 44-136 (144) alignment
Range on Protein: 79-178
Range on HMM: 44-136/144.0
KETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS----KSVVVHCSTGIGRAAAFAFTELAYqtmmlnmrqtpTVGLDYVKLIQDLRSMRAGAIYTPM
 ..... .|.. .|   . |.|.  .|........     . |.|||| |.||.....   | .           . ||.. . .. .||.| ||...| 
fleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...........klglsleealalvrsrrpgavpnpg

QLAF
|| |
qlrf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 80-217 1.9e-10 34.9 In-house 174-306 (312) alignment
Range on Protein: 80-217
Range on HMM: 174-306/312.0
ETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTElayqTMMLNMRQTP--TVGLDYVKliqdLRSMRAGAIYTPMQL
.   . || .  |  .  |.     | .. ||.| |  |. |||.|.||. ..|. |    .|.  .|.     |   .|     ||  || .. .  | 
qesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlalie....smiaalrhprkqnvkdsfvl....lrkdrarsvrvfpqy

AFSIIMLLDFVLENELSKETNIKYQQIRNSYLDLRKRKYRT
 ...  .|.|.  . | |  . .. .....|  .. .| . 
vyalrcvleflyskglykrneqewtkfketyakikakklki

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 81-184 5.2e-06 20.4 In-house 167-274 (287) alignment
Range on Protein: 81-184
Range on HMM: 167-274/287.0
THTIRHYFYKGWIAQN-GPE---LSREILNV---FKAVRKSK---SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQtpTVGLDYVKLIQDLRSMRAGAI
.. .. . .  | ..   |    | | .|.|    .. |...    .|||...||||.  .    ||  ...  . .  .  .|  . .  ||  ||. .
arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil....latlvlvsrled..lGrvdvaavvirlreyraalv

YTPMQLAFSIIMLL
 ...|| ...  | 
qavvqlrllyealv

PTPc_DSPc_SM00012 83-184 1.5e-17 59.1 In-house 1-104 (105) alignment
Range on Protein: 83-184
Range on HMM: 1-104/105.0
TIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-------SVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptVGLDYVKLIQDLRSMRAGAIYTPMQ
|..|| |.||  .. || | .||....||.|.|       .||||||.|.||.. |.  ....| .. .        .|  .... ||..|.|.. | .|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.....kevdifqivkelrkqRpgmvqteeq

LAFSIIMLL
  | . .||
ylflyrall

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 86-196 4.4e-06 20.3 In-house 189-294 (302) alignment
Range on Protein: 86-196
Range on HMM: 189-294/302.0
HYFYKGWIAQNGPELSREILNVF-KAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTmmLNMRQTPTVGldyvKLIQDLRSMRAGAIYTPMQLAFSIIMLL
..  .  . ..  || ... .|| | .  ....|.    |.|||.||    .| ..  |.  . | .      ... .|| |. |. .  | ..  |.||
tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek..lqkgkepnik....eivksiRsqRpravdslkQyvslyiall

DFVLENELSKET
 .....  . |.
lyikkkvtkpee

subfamily_egg_pd Subfamily egg 104-202 9.4e-07 22.8 In-house 190-286 (307) alignment
Range on Protein: 104-202
Range on HMM: 190-286/307.0
ILNVFKAVR-KSKSVVVHCSTGIGRAAAFAFTELAyqtMMLNMRQtPTVGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLE-NELSKETNIKYQ
 |.|.. .|  || |||..  |. .||..   |.|   ..  .|  |..     . .. ||  |  .. ....  |   ..| |. .    .|| .. |.
plrvlrklrnlskpvvvqdilGvskaatlvaieia...llsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdye

Q
.
r

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 111-163 9.6e-06 19.5 In-house 259-312 (350) alignment
Range on Protein: 111-163
Range on HMM: 259-312/350.0
VRKSKSVVVHCSTGIGRAAAFA-FTELAYQTMMLNMRQTPTVGLDYVKLIQDLR
  .|....|||| |.||.  .  .  |  .. .|.. .   . ||. . ..|| 
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

subfamily_CG42327_pd Subfamily CG42327 116-180 7.3e-06 19.9 In-house 249-308 (319) alignment
Range on Protein: 116-180
Range on HMM: 249-308/319.0
SVVVHCSTGIGRAAAFAFTELAYQTMmlnmrQTPTVGLDYVKLIQDLRSMRAGAIYTPMQLAFSI
 .||||| |.||.     ...| ...     ...   .|  .|.. .|  || |. |  | .|  
PlvvhcsdGvGrtGlviasdiairsl.....eeskrsvdiPqlvssvrrdrasavltkeqyefiy