Gene hpo-7 in Caenorhabditis elegans

Synonym: CELE_C40A11.5, hpo-7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily hpo-7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP112_AA protein Get Run
CeleP112_AA_0-188 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_hpo-7_pd Subfamily hpo-7 1-215 8.9e-91 298.4 In-house 1-255 (263) alignment 
Range on Protein: 1-215
Range on HMM: 1-255/263.0
MILT-QGPIHWKTLPKSVDDVDECAQGVEPSRPP-----YS----TMDKFLQMIVQTKATDVVMLGDFYEN-----------------------------
..|. .|......||....|.|.|.....|....     ||    |.|||.|.|||||...||||.||.|.                             
kllndkgalkfgklPrilidedvctehfkPekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkv

--DVVLRTIEITSNFSKsKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQTPTVGLDYVKLI
  ||.|.|.|..|.... ||.|||..||.|||||..|.|||.|||||..|..|.|||.||||||||||.|||...||.||.|......|.||.|||..|.
qsdvllktlellstlge.KkkthtvkhysykgWiekndpelareilnilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLl

QDLRSMRAGAIYTPMQLAFSIIMLLDFVLENELSKETNIKYQQIRNSYLDLRKRKY
..|||.|..||.|||||||||.|.|||||.|    | . |||.||.|||  |.  .
eelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeirksylharqmmh
0040438 (Phosphotyrosine protein) phosphatases II 2-193 7.6e-33 109.5 In-house 89-282 (317) alignment 
Range on Protein: 2-193
Range on HMM: 89-282/317.0
ILTQGPIhwktlpksvddvdecaqgvepsrppYSTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEI
|.||||                           .|...|..|. . . | .||| .. |.                               ...|||.|.
IatqgPl.........................pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlev

TSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSM
. .    ..|..|..|. |.||  .. |.  ...|. ..|||.     .. |.|||| |.||...|.  .|... .  ..      |.|. . .. ||..
edl...gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg......gvdveeavkelreq

RAGAIYTPMQLAFSIIMLLDFVLENELS
|.||..||.|. | . .||.... .. .
Rpgavqtpeqyrflydalleylkrkltl
0036941 (Phosphotyrosine protein) phosphatases II 2-191 2.7e-32 107.7 In-house 81-281 (297) alignment 
Range on Protein: 2-191
Range on HMM: 81-281/297.0
ILTQGPIHwktlpksvddvdecaqgvepsrppySTMDKFLQMIVQTKATDVVMLGDFY-----------------------------------ENDVVLR
|.|||| .                         .|...| .|. . . | .||| ...                                   ..|..||
IatqgPlp.........................ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlr

TIEITSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqTPTVGLDYVKLI
|.|.| .    ..|..|..|. |.||   . ||  ...|. ...|||       .. |.|||| |.||...|.  .|..| .  .   . . |.|.....
tlevtdt...gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledk...lkeggvdileav

QDLRSMRAGAIYTPMQLAFSIIMLLDFVLENE
. ||..|.||. |..|. | . .||.... ..
kklReqRpgavqtleqyrflyeallellkkkl
0050432 (Phosphotyrosine protein) phosphatases II 2-188 3e-31 104.3 In-house 111-300 (308) alignment 
Range on Protein: 2-188
Range on HMM: 111-300/308.0
ILTQGPIhwktlpksvddvdecaqgvepsrppYSTMDKFLQMIVQTKATDVVMLGDFYEN----------------------------------DVVLRT
|.||||                          ..|...| .|. . . . .||| ...||                                  |...||
IatqgPl.........................pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrt

IEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS---KSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtptVGLDYVKLIQDLRS
.|.|    ....|..|..|. |..|  .. |.  ...|. ...||||   . .||||| |.||...|.  .|... .  .       |.|. .... ||.
leltn...lgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke......ggvdvfeavkklRe

MRAGAIYTPMQLAFSIIMLLDFVL
.|.|.. ||.|. | . .||....
qRpgmvqtpeqylflyralleylk
0047943 (Phosphotyrosine protein) phosphatases II 2-187 1.7e-30 101.8 In-house 80-272 (273) alignment 
Range on Protein: 2-187
Range on HMM: 80-272/273.0
ILTQGPIhwktlpksvddvdecaqgvepsrppYSTMDKFLQMIVQTKATDVVMLGDFYEN----------------------------------DVVLRT
|.||||                          ..|...|..|. . ... .||| ...|.                                  |...||
iatqgPl.........................pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrt

IEITSNFsksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQ
.|.|..     .|..|..|. |.||  .. |.   ..|. ...|||       .. |||||| |.||...|.  .|... .  .       |.|. ....
leltnlg...tgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg......gvdvleavk

DLRSMRAGAIYTPMQLAFSIIMLLDFV
 |||.| |...|| |. | . .||...
llrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 2-188 2.2e-29 98.3 In-house 104-290 (297) alignment 
Range on Protein: 2-188
Range on HMM: 104-290/297.0
ILTQGPIHWktlpksvddvdecaqgvepsrppysTMDKFLQMIVQTKATDVVMLGDFYEN-----------------------------DVVLRTIEITS
|.|||| .                          |...|..|. . . | .||| .. |.                             ....||.|.| 
IatqgPlpe.........................tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn

nfsksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtptVGLDYVKLIQDLRSM
     ..|..|..|. | ||   . |.... .|.....||       |.. |.|||| |.||...|.   |... .  .       |.|. . .. ||..
.....ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke......ggvdvleavkelreq

RAGAIYTPMQLAFSIIMLLDFVL
| ||. || |. | . .||....
Rpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 2-188 3.9e-29 97.8 In-house 110-305 (307) alignment 
Range on Protein: 2-188
Range on HMM: 110-305/307.0
ILTQGPIHWktlpksvddvdecaqgvepsrppysTMDKFLQMIVQTKATDVVMLGDFYEN--------------------------------DVVLRTIE
|.|||| .                          |...|..|. . . | .||| .. |.                                ....||.|
IatqgPlpe.........................tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtle

ITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQTPtvgLDYVKLIQDL
.| .  . ..|..|..|..|.||  .. |.   |.|. ...||       |.. |.|||| |.||...|.   |... .  .   .    .|. . .. |
vtdl..dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlld...vdlleavkll

RSMRAGAIYTPMQLAFSIIMLLDFVL
|..| ||. .| |. | . .||...|
reqRpgavqnpeqyrflyeallelll
0040439 (Phosphotyrosine protein) phosphatases II 2-188 3.6e-27 91.0 In-house 57-247 (249) alignment 
Range on Protein: 2-188
Range on HMM: 57-247/249.0
ILTQGPIHWktlpksvddvdecaqgvepsrppysTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEI
|.|||| .                          |...|..|. . . | .||| .. |.                               |...||.|.
iatqgPlpe.........................tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

TSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtptVGLDYVKLIQDLR
| .    ..|..|..|. | .|  .. |.   ..|. ..||||       .. |.|||| |.||...|.   |... .  .       |.|.   ...||
tnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke......lgvdleeavkllr

SMRAGAIYTPMQLAFSIIMLLDFVL
|.| ||...| |. | . .||...|
sqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 2-188 1.8e-26 88.6 In-house 67-273 (278) alignment 
Range on Protein: 2-188
Range on HMM: 67-273/278.0
ILTQGPIHwktlpksvddvdecaqgvepsrppySTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEI
|.||||                           ||...|..|. . . | .||| ...|.                               |..|||...
IatqgPlp.........................stvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllv

TS-NFSKSKKETHTIRHYFYKGWIAQNGPELS--REILNVFKAVR------------------KSKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmrqtp
|  .. ..  |.....|. |..|   . |.|.  . .|.... .|                  ... |.|||| |.||.....   | .. .        
tnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell........

TVGLDYVKLIQDLRSMRAG-AIYTPMQLAFSIIMLLDFVL
  |.|. . .. |||.| | |. ...|. | . .||...|
eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0051299 (Phosphotyrosine protein) phosphatases II 3-187 2.7e-30 101.2 In-house 96-286 (288) alignment 
Range on Protein: 3-187
Range on HMM: 96-286/288.0
LTQGPIHwktlpksvddvdecaqgvepsrppySTMDKFLQMIVQTKATDVVMLGDFYEN-------------------------------DVVLRTIEIT
.|||| .                         .|...| .|. . . . .||| ...|.                               |...||.|.|
atqgPlp.........................ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevt

SN-FSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSM
 . . . ..|..|..|. |..|  .. |.  ...|.  ..|||.     . |||||| |.||...|.  .|... .  .       |.|. .... ||..
nldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeg......gvdvleavkrlreq

RAGAIYTPMQLAFSIIMLLDFV
| |.. ||.|. | . .||...
Rpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 3-62 4e-21 70.2 In-house 1-66 (255) alignment 
Range on Protein: 3-62
Range on HMM: 1-66/255.0
LTQGPIHWKTLPKSVDDVDECAQGVEPSRPP-----YS-TMDKFLQMIVQTKATDVVMLGDFYEND
|..|....|.||....|.|.|...|.|....     || |.|||.|.|||||...||||.||.|..
ldkGalkfkklPrilidedvctehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeeg
0042113 (Phosphotyrosine protein) phosphatases II 30-186 4.1e-27 90.6 In-house 63-242 (245) alignment 
Range on Protein: 30-186
Range on HMM: 63-242/245.0
SrppysTMDKFLQMIVQTKATDVVMLGDFYEND-------------------------------VVLRTIEITSNfskSKKETHTIRHYFYKGWIAQNGP
.     | ..|..|. . . | .||| .. |..                               ...||.|.| .    ..|.....||.| .|  .. |
e.....tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnl...gddesrevihyhylpwpdhgvp

ELSREILNVFKAVRK------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDF
.|.. .|.....|||      .. |.|||| |.||...|.   |... .  ..      |..  . ...|||.| ||. || |. | . .||..
dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekel......gvsleeavkelrsqRpgavqtpsqyrflyeallel
0041856 (Phosphotyrosine protein) phosphatases II 30-190 8.8e-20 66.5 In-house 40-174 (182) alignment 
Range on Protein: 30-190
Range on HMM: 40-174/182.0
SRPPYSTMDKFLQMIVQTKATDVVMLGDFYENDvvlrtieitsnfsksKKETHTIRHYFYKGWIAQNGPElSREILNVFKAVRKS-KSVVVHCSTGIGRA
 .|..||. .||.|. . . | .|.| ... .                ....... .|.| .|   . |.  .|.|.  ..|... . |.|||| |.||.
qgpllstvadflrmlkelgittivnlteelywp...............ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRt

AAFAFTELAYQTmmlnmrqtptvGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLEN
....   | ..            |... . .. .||.| |.. || |. |   .||...| .
gtlvaaylmkkl...........gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0046845 (Phosphotyrosine protein) phosphatases II 31-188 1.5e-30 102.0 In-house 84-275 (284) alignment 
Range on Protein: 31-188
Range on HMM: 84-275/284.0
RPPYSTMDKFLQMIVQTKATDVVMLGDFYEND--------------------------------VVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGP
 |  .|...| .|. . ... .||| .. ||.                                ...||.|.| .  . ..|..|..|. |..|  .. |
gPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvp

ELSREILNVFKAVRK-------SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtPTVGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVL
. .. .|. ...||.       .. .||||| |.||...|.  .|... .  .    ...|.|. .... ||..| |.. |..|. | . .||....
pspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeg...lllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0043336 (Phosphotyrosine protein) phosphatases II 31-186 9.7e-28 92.8 In-house 95-276 (278) alignment 
Range on Protein: 31-186
Range on HMM: 95-276/278.0
RPPYSTMDKFLQMIVQTKATDVVMLGDFYEND------------------------------VVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPEL
 |  .|...| .|. . . | .||| .. |..                              ...||.|.|    . ..|..|..|| |.||  .. || 
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpes

SREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDF
   .|.  ||||.     .. |.|||| |.||...|.  .|... .. .       |.|. . ...||..|.||. ||.|. | . .||..
lsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg......gvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 31-197 9.6e-11 35.7 In-house 95-242 (392) alignment 
Range on Protein: 31-197
Range on HMM: 95-242/392.0
RPPYSTMDKFLQMIVQTKATDVVMLGDFYENDvvlrtieitsnfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGI
 |  ...| | .|. | ..| ..|. .. | |                ....|.  ...  |  .. |. .  .|.. | |.      .. ...|||.|.
gpnaaslddfwrmvfqenvttiamvtklkegd..............kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagv

GRAAAFafteLAYQTMMLNMRQTPTVglDYVKLIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETN
||..      .. ....   ..|  |  | .... ..|  |   . |  | ||    .   |||. | ..| 
grtgvv....isidsvvahakktrmv..dvfnfvtnirrkrpymvqtkeqyaf....iygavledllwrntl
0037934 (Phosphotyrosine protein) phosphatases II 32-183 2.6e-24 81.5 In-house 52-238 (243) alignment 
Range on Protein: 32-183
Range on HMM: 52-238/243.0
PPYSTMDK----FLQMIVQTKATDVVMLGDFYEN-----------------------------DVVLRTIEITSnfSKSKKETHTIRHYFYKGWIAQNGP
|  .| .     |..|. . . | .||| ...|.                             |...||....    . ...|....|| | .|  .. |
PlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen..ldlddltrlvihyhylpwpdhgvP

ELSREILNVFKAVRK-------------SKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmrqtptvGLDYVKLIQDLRSMRAG-AIYTPMQLAFSIIML
.    .|. ...||.             .. |.|||| |.||.....   | .. .          |.|. . ...||..| | |. || |. | . .|
dspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll..........gvdleeavkllreqRpgkavqtpsqyrflyeal
0043147 (Phosphotyrosine protein) phosphatases II 32-179 8.7e-21 69.8 In-house 28-153 (172) alignment 
Range on Protein: 32-179
Range on HMM: 28-153/172.0
PPYSTMDKFLQMIVQTKATDVVMLGDFyendvvlrtieitsnFSKSKKETHTIRHYFYKGWIAQNGPeLSREILNVFKAVRK------SKSVVVHCSTGI
|  .|...|..|. . . | .|.| ..               .   ....... .| | .|  .. | |.. .|.... ...      .. |.|||| |.
plrntladfwrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGv

GRAAAFAFTELAYqtmmlnmrqtptVGLDYVKLIQDLRSMRAGAIYTPMQLAFS
||.....   | .             ||.. . .. .|..| ||...| |. | 
gRtgtlvaaylml............lglsleeavalvrekRpgavqnpsqyrfl
0049260 (Phosphotyrosine protein) phosphatases II 32-178 1.2e-18 62.7 In-house 17-141 (152) alignment 
Range on Protein: 32-178
Range on HMM: 17-141/152.0
PPYSTMDKFLQMIVQTKATDVVMLGDFYENDVVLRTIEItsnfskskkethtirHYFYKGWIAQNGPELSREILNVFK-----AVRKSKSVVVHCSTGIG
|   |...|..|. . ..| .||| ...|.. .     |               .|..  |   . |.||  .| ...     | .|.. |.|||| |.|
pgpntladfwrmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

RAAAFAFTELAYqtmmlnmrqtptVGLDYVKLIQDLRSMRAGAIYTPMQLAF
|.....   | .             |... . .. .|..| ||...| || |
Rtgtlvaaylml............lgvsleeavalvrekRpgavpnpgqlrf
0046846 (Phosphotyrosine protein) phosphatases II 32-179 2.5e-17 58.7 In-house 31-165 (176) alignment 
Range on Protein: 32-179
Range on HMM: 31-165/176.0
PPYSTMDKFLQMIVQTKATDVVMLGDFYENDVV--LRTIEITSN--FskskkethtirHYFYKGWIAQNGPELsREILNVFKAVRKSK----SVVVHCST
| ..|. .||.|. . . | ||.| . .| . .   .  ..  .  .           .|.. .|   . |.| . .|......|.       |.|||| 
plprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsa

GIGRAAAFAFTELAYQtmmlnmrqtpTVGLDYVKLIQDLRSMRA-GAIYTPMQLAFS
||||.....   | .             ||.. . .. .|..|  ||. || |. | 
GigRtgtlvaayllel..........ekglsveealalvreqRplgavqtpeQyrfl
0051429 (Phosphotyrosine protein) phosphatases II 32-189 5.7e-17 57.7 In-house 30-227 (272) alignment 
Range on Protein: 32-189
Range on HMM: 30-227/272.0
PPYSTMDKFLQMiVQTKATDVVMLGDFYENDVVLRT----------------IEITSNFSK-------------------------SKKETHTIRHYFYK
|   | . | ..  . . . .|.| . .| . .                    . | .. .                         | .|.....|..| 
plpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhyt

GWIAQNGPELSreILNVFKAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmrqTPTVGLD--------YVKLIQDLRSMRAGAIYTPMQLAFSIIM
.|.  . |. .  .|.......... |.|||| |..| . ..   | .. .      . .. .|        . . .. ||..|.||. |..|..|    
dwpdhgvpqea..llellellldggpvlvHCsaGkdRTGtvvallllllgv......sletivddYlltnlyleeaveelraqrpgavqteeqylflyea

LLDFVLE
||... .
llellrs
0049772 (Phosphotyrosine protein) phosphatases II 32-186 5e-12 41.6 In-house 92-279 (314) alignment 
Range on Protein: 32-186
Range on HMM: 92-279/314.0
PPYSTMDKF----------LQMIV--QTKATDVVM---------------------LGDFYENDvvlrT----------IeitSNFSKSKKETHTIRHYF
|   |.. |          ..|..  . .  |.||                     | .. .|                    .     .. .... .|.
pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk...eelydpelferlgikyl

YKGWIAqNGPELSREILNVFKAVR---KSKSVVVHCSTGIGRAAAFAFteLAYqtMMLNMrqtptvGLDYVKLIQDLRSMRA-----GAIYTPMQLAFSI
.  .   ... |.. .. ......   | . |.|||. |.||.. |..  .||  .|. .      |... . ..|.|..|      |.|....|. |  
ripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvv..aay..lmkll......gvsleealedvrlkRpinpnpgfieqleqyefil

IMLLDF
  ||..
ealley
0036282 (Phosphotyrosine protein) phosphatases II 35-178 1.3e-17 59.5 In-house 27-161 (174) alignment 
Range on Protein: 35-178
Range on HMM: 27-161/174.0
StmdkFLQMIVQTKATDVVMLGDFYENDVVLRTI---EitsnfsKSKKETHTIRHYFYKGWIAQNGPELSReILNVFKAVRK------SKSVVVHCSTGI
.    |..|. . . |.|||| . .|.. ..      |      ... ..... .|.| .|   . |.||  .|...|.|..      .. |.|||| |.
a....fwemlkelgittvvmlleekelglykcinywpe......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGv

GRAAAFAFTELAYQTMMLNMRQTptvgldyVKLIQDLRSMRAGAIYTPMQLAF
||.....   | .. .. ....        ..|.. ||..| |...|| |. |
gRtGtlvaaylmlrglleslvda.......ldlvrelRlqrpgmvqtpsQyrf
0051082 (Phosphotyrosine protein) phosphatases II 37-181 4.6e-16 54.2 In-house 22-147 (151) alignment 
Range on Protein: 37-181
Range on HMM: 22-147/151.0
MDKFLQMIVQTKATDVVMLGDFYENDvvlrtieitSNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK--SKSVVVHCSTGIGRAAAFAFT
.. ||... . . . .|.| . .|..          . .  ... ....|. . .| ... |..  ..|........  .. |.|||| |.|| ....  
ladflellkelgiktivnlrseeerg.........ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlval

ELAYQTmmlnmrqtptvgLDYVKLIQDLRSMRAGAIYTPMQLAFSII
 | ..             ... . ....|..| |......|  | ..
ylmllg............vsleealeeyrlkrpgvvqpnqqflfqlf
0044763 (Phosphotyrosine protein) phosphatases II 38-178 9.1e-14 47.0 In-house 38-162 (178) alignment 
Range on Protein: 38-178
Range on HMM: 38-162/178.0
DKFLQMIVQTKATDVVMLGDFYENDVVLRTIEITSNFSkskkethtiRHYFYKGWIAQNGPELSREILNVFKAV-----RKSKSVVVHCSTGIGRAAAFA
 ..|... . . | .|.| . .|.  .    .  ....          .|.. ..   . |.|.. .|......     .| . |.|||| |.||.....
addlellkelgithivnlteelelgflkcdpywpeeag.........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlv

FTELAYQTmmlnmrqtptvGLDYVKLIQDLRSMRAgAIYTPMQLAF
   | ..            ||.. . |. .|..|  ....| || .
aaylmkkl...........glsleeaielvrerRp.ivpnpgqlrq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 51-218 4.1e-13 44.1 In-house 147-307 (318) alignment 
Range on Protein: 51-218
Range on HMM: 147-307/318.0
DVVMLGDFYENDVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLN
 | .  ..  .| |||....|    . ..|. ..| | |  |  .. || . ..|.. . |.| .       .|||||.|.||.  |    .| ....  
vvelkeevelsdyvlrefkvtr...teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvf....iavdiller

MRQTPTVglDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVleneLSKETNIKYQQIRNSYLDLRKRKYRTS
...  .|  |  . .. ||. |   . |  |  |   .||...     | .|... ...|.   .||...  . 
ikaealv..Dvfqtvkqlreqrnlmvqtedqyefiydvlleal....asgdtevdasdlrsrirelreqdpesg
subfamily_PTPN9_pd Subfamily PTPN9 55-190 1.4e-10 35.7 In-house 149-293 (297) alignment 
Range on Protein: 55-190
Range on HMM: 149-293/297.0
LGDFYENDVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------------------SVVVHCSTGIGRAAAFAftEL
. .  |.| . |..||.      ..|. .. |. . .|     |. . ..|.| ..||. .                   .|||||.||||. .|.   |
veveeeedykvrvleikn...vkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfi..tl

AYQTMMLNMRQTptvgLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLEN
 .    |.. .|    .| |. .. ||. || .| || | .|  . .|.. ||.
diclsrleevgt....vdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN12_pd Subfamily PTPN12 57-187 9.6e-15 49.2 In-house 150-277 (290) alignment 
Range on Protein: 57-187
Range on HMM: 150-277/290.0
DFYENDVVLRTIEITSNfskskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAFteLAYQTMMLNMRQTPTv
.  ..| ..||.... .     ||..... . |. |  .. |.   ..|.. ..||.      . .||||| |.||. .     . |  ..|. ...|  
kavdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiia..idyvrellkaekipe.

GLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 ||  .|...||  || .. |  |  .    ....|
eldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 59-187 4.9e-11 36.8 In-house 144-269 (281) alignment 
Range on Protein: 59-187
Range on HMM: 144-269/281.0
YENDVVLRTIEITSNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-KSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqTPtvglDYVK
||.  | ...  |      . ||. | |...| |   . || |  .|.... .| .|   |.|||.|.||. ..   |.| |..   .   |    |  .
yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshft.lp....dikq

LIQDLRS-MRAGAIYTPMQLAFSIIMLLDFV
..  ||   || .. |  |  .   .|||| 
ivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 60-206 2.4e-22 74.4 In-house 140-278 (290) alignment 
Range on Protein: 60-206
Range on HMM: 140-278/290.0
ENDVVLRTIEITsnFSksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQtptvgLDYVKL
|.||  |.....  |   ..| .|. |. .|||   | .| .. .|.. . |..||  |.|||  || | ||.|  .|.|| ..    .     .  ...
eddvetRelvvk..fd..deeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgs.....vkledv

IQDLRSMRAGAIYTPMQLAFSI--IMLLDFVLENELSKETNIkyQQIRNS
...||..|| || ....||| .  |.|| .   .. ..|...  ..... 
lkalrkqralaitsalelafvdagivllaievldqfaeeete..kkakae
Y_phosphatase Protein-tyrosine phosphatase 60-183 1.3e-20 69.2 Pfam-A 113-233 (235) alignment 
Range on Protein: 60-183
Range on HMM: 113-233/235.0
ENDVVLRTIEITSNFSKSkkETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLD
|....||..|.... ..|  |....... |..|  .. || ....|.. ..|.|||     .||||||.|.||.. |.  ... . .  .        .|
ekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee......vd

YVKLIQDLRSMRAGAIYTPMQLAFSIIML
 ..... ||. |.|.. .  |..| . ..
vlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 60-183 1.3e-20 69.2 In-house 113-233 (235) alignment 
Range on Protein: 60-183
Range on HMM: 113-233/235.0
ENDVVLRTIEITSNFSKSkkETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLD
|....||..|.... ..|  |....... |..|  .. || ....|.. ..|.|||     .||||||.|.||.. |.  ... . .  .        .|
ekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee......vd

YVKLIQDLRSMRAGAIYTPMQLAFSIIML
 ..... ||. |.|.. .  |..| . ..
vlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRK_pd Subfamily PTPRK 60-217 6.8e-17 56.3 In-house 152-303 (314) alignment 
Range on Protein: 60-217
Range on HMM: 152-303/314.0
ENDVVLRTIEITsNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTelayqTMMLNMRQTPTVgLD
....| |.  .. . .....|....|.. . || . . |   . .|.. . | ||.      .|||||.| ||. .|        ...|.| ..  | .|
laelvvrifrve.klargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiai.....divldmieregv.vd

YVKLIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETNIKYQQIRNSYLDLRKRKYRT
  . ...||| .   . |  |  |    . | .||  |  || |   .... ||.  .   .|
vfnavktlrsrkvnmveteeqykf....iydvileaclcgetaipvsefkalylesirldpqt
subfamily_PTPN6_pd Subfamily PTPN6 60-187 1e-13 46.0 In-house 166-297 (306) alignment 
Range on Protein: 60-187
Range on HMM: 166-297/306.0
ENDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS---------KSVVVHCSTGIGRAAAFAFTELAYQTMMlnmRQTPT
 .| .||.. .. .  |.|||......| .| |  .. |.    .|. .. |..           ..||||| ||||  .|  ...  ....   ..   
ladYilRelsvskk..kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie...kkgld

VGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
. .|  ||.. .|. | | . |  |  |   ..  ..
adidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 60-186 2.1e-12 42.2 In-house 129-257 (284) alignment 
Range on Protein: 60-186
Range on HMM: 129-257/284.0
ENDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVg
 .. |.| ||.. .    .|.  .|| . ..||  .  |. . ... . | ||       . ...|||||.|.||. ..    .. ....  |..   | 
seeyvvrdielsed..gkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy....ivldvlldrmkeekqv.

lDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLD---F
 |  ....|||  |   .   .|  |  . ||.   |
.dvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 60-185 2.2e-12 41.9 In-house 165-289 (319) alignment 
Range on Protein: 60-185
Range on HMM: 165-289/319.0
ENDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR-------KSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVg
 .. |.| ||.. .    .|.   |. . ..||  .  |. . ... . | ||       . ...|||||.|.||. ..    .. ....  |..   | 
taeyvvrdielsed..gkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy....ivldvlldrmkeekqv.

lDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLD
 |  ....|||  |   .   .|  |  . ||.
.dvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN13_pd Subfamily PTPN13 60-180 1.4e-10 35.9 In-house 147-262 (273) alignment 
Range on Protein: 60-180
Range on HMM: 147-262/273.0
ENDVVLRTIEITSNFSkskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS----VVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptvGLDY
 .. |.|..... . |   .|.. . |  .  |   . |  . |.|.. . ||. ..    .|||||.||||. ..   . . . .  .        .| 
ldgfvvralavkdses...gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk......efdv

VKLIQDLRSMRAGAIYTPMQLAFSI
 .....||  | | . |  |  |  
keivrklreqrqgvvqtkdqyifvy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 60-183 2.4e-09 31.6 In-house 153-274 (287) alignment 
Range on Protein: 60-183
Range on HMM: 153-274/287.0
ENDVVLRTIEITSNFSksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAV----RK--SKSVVVHCSTGIGRAAAFAFTElayqtMMLNMRQTPTvGL
..... |..|.. . .  ........ | .  |  .   .  . || |..      ||    |.||||| ..||.| |   .     . .|  .|   ..
nagyierklevknknk..agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaa.....ttinkckteG.vi

DYVKLIQDLRSMRAGAIYTPMQLAFSIIML
| .....  |  . |.. |  |  | . ..
Dvfqvlksqriqkpgsvqtveqykfindiv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 60-178 2.2e-07 25.2 In-house 138-250 (267) alignment 
Range on Protein: 60-178
Range on HMM: 138-250/267.0
ENDVVLRTIEItsNFskSKKETHTIRHYFYKGWI--AQNGPELSR--EILNVFKAVRKSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTvgLDY
|||  . |.|.  .|   .. .| .  |.|| |   ..| | |     ||   .    .. .||.|| |.||. .|    |  ....  ...  .  .| 
endyqiitlel..kf..knesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf....lvidsqleraktegv..sdi

VKLIQDLRSMRAGAIYTPMQLAF
 .... .|| | | . |  .  .
fdflrkirsqriglvdtkeryiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 61-216 4.2e-74 243.8 In-house 96-247 (255) alignment 
Range on Protein: 61-216
Range on HMM: 96-247/255.0
NDVVLRTIEITSNFSKsKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQTPTVGLDYVKLIQ
.||||||.||||.... ||.|||..||.|||||..|.|||.|||||..|.||.||||||||||||||.|||...||.||.|......|.||.|||..|..
advvlrtleitstlge.kkkthtvkhysykGWieknaPelareilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslle

DLRSMRAGAIYTPMQLAFSIIMLLDFVlenELSKETNIKYQQIRNSYLDLRKRKYR
.|||.|..||.||.||||||.|.||.|      .| . |||.||.|||  |.  ..
elrskrkraihtPlqlafsilmvldlv...fpkgeleakyqeirksylharqmmhk
DSPc_SM00195 61-187 1.3e-22 75.7 In-house 140-262 (263) alignment 
Range on Protein: 61-187
Range on HMM: 140-262/263.0
NDVVLRTIEITSNFSkskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-----VVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLDY
....|||.|.| .     .||.....| ||.|  .. |.  ...|....||.||||     .|||||.|.||...|. ...... .  . .      .| 
deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk......vdi

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 .... ||. |.|.. | .|..| . ..|...
feivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 61-187 1.3e-22 75.7 In-house 140-262 (263) alignment 
Range on Protein: 61-187
Range on HMM: 140-262/263.0
NDVVLRTIEITSNFSkskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-----VVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLDY
....|||.|.| .     .||.....| ||.|  .. |.  ...|....||.||||     .|||||.|.||...|. ...... .  . .      .| 
deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk......vdi

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 .... ||. |.|.. | .|..| . ..|...
feivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 61-221 6.1e-17 56.6 In-house 159-313 (319) alignment 
Range on Protein: 61-221
Range on HMM: 159-313/319.0
NDVVLRTIEItsNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS------VVVHCSTGIGRAAAFAftelAYQTMMLNMRQTPTvgLD
.|.. | ...  |  .|. || .. |. |. |  .. || .. .|...| .|||..      .||||| |.||  .|     . . |. ....  .  ||
edyiirklkl..nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfi....vldamlervkeegv..lD

YVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVleneLSKETNIKYQQIRNSYLDLRKRKYRTSEEY
  . .. ||  |   . .| |  |    ||..|     . .|.|. |..|.   .|....  | | .
vfstvsrlRtqRnimvqrpeqYkfiyealleav....eagdteievqdlrdrlkqlaekvadtgetg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 61-189 3.6e-13 43.8 In-house 165-285 (290) alignment 
Range on Protein: 61-189
Range on HMM: 165-285/290.0
NDVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-KSVVVHCSTGIGRAAAFAFTELAYQTMmLNMRQtptvgLDYVKLI
......|. .     | .   | ..|.  | |  .  .  .  .| .....||    ||||||.||||. .|.  | . | . |. ..     || ..|.
aniikktlsvrd...kdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqil.ldGke.....ldlldlv

QDLRSMRAGAIYTPMQLAFSIIMLLDFVLE
. ||  |....   .|    . .|||.  .
ralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 61-202 4.2e-12 40.8 In-house 159-294 (305) alignment 
Range on Protein: 61-202
Range on HMM: 159-294/305.0
NDVVLRTIEITSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS------KSVVVHCSTGIGRAAAFAFTElayqTMMLNMRQTPTVglD
.| . | ..|. .  ...||..|. .|    |  .  |. .  .|...| |.|.      ....|||| |.||. .|   .     ..  ...  .|  |
sdyieRklkisie..dedkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavd....ialerlkkEevv..d

YVKLIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETNIKYQQ
  .... ||| | ... |  |  |    | | . |   . .|.|  . 
vfevlkqlRskrmkmvqtldqYvf....lhdaldelitcgdtsiigsn
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 61-187 2.8e-11 37.8 In-house 159-283 (290) alignment 
Range on Protein: 61-187
Range on HMM: 159-283/290.0
NDVVLRTIEITSNFSKskKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK------SKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmRQtpTVGLD
|. . |..|.... |.  ...... .|  . |  .   .    || |.. . |       .|.||||| ..||.| |  .. . . .    ..  . . |
neyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkc....kt..egvid

YVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
 ..... .|. . | . |  |. . . ..|  .
vfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Ptp69D_pd Subfamily Ptp69D 61-188 3.9e-11 37.6 In-house 159-287 (307) alignment 
Range on Protein: 61-188
Range on HMM: 159-287/307.0
NDVVLRTIEITSNFSKS--KKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR----KSK-SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVgl
.| . |..... .  .|   .... .  | |.||   . || .| .|.. . ||    ...  .|||||.| ||.. |    .| . .. ....  .|  
sdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif....valdsllqqlkaedkv..

DYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVL
| .. ..|||| |   .    |  |    |||.  
difetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 61-206 4.7e-08 27.5 In-house 160-303 (325) alignment 
Range on Protein: 61-206
Range on HMM: 160-303/325.0
NDVVLRTIEITSnfsKSKKETHTIRHYFYKGWI---AQNGPELSREILNVFKAV----RK----SKSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTP
 | | | ...      .| || ... . ...|     |. |     ||.. |||    .     |  ..||||.|.||. .|.    .  ... .. .  
sdyvhrvldvkq...vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfi....slysalakviees

TVglDYVKLIQDLRSMRAGAIYTPMQLafsiIMLLDFVLENELSKETNIKYQQIRNS
 |  |  . .. ||  |   . |  |     |.. . . |  .| .|..    .   
rv..difgfvkklrkdrpsmvetvdqy....iliyealveaymsgntdvpvssfeak
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 62-180 8.1e-16 52.6 In-house 163-274 (301) alignment 
Range on Protein: 62-180
Range on HMM: 163-274/301.0
DVVLRTIEITSnfSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTELayqtMMLNMRQTPTVGLDyvKLIQ
... ||.|..   |  | .|.|. || |. | ... |.   |. .. . |.||.  .|||||.||||. ||  ||     .  ..   ||. |   . ..
kiskrtleved..stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigtey....lareveadptielt..ealk

DLRSMRAGAIYTPMQLAFSI
.||  |  .. |  || .  
hlrehrwngvqtnsqlywmt
subfamily_PTPRD_pd Subfamily PTPRD 62-220 1e-15 52.5 In-house 160-310 (564) alignment 
Range on Protein: 62-220
Range on HMM: 160-310/564.0
DVVLRTIEItSNfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYV
|...||... ..  |...|....|.. .  |  .. ||  ...|.. . ||..     . .||||| |.||  .|    .. . |.  ...  ||  |  
dyeirtfkl.kk..kkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtf....ividamlerikeektv..Diy

KLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVleneLSKETNIKYQQIRNSYLDLRKRKYRTSEE
. .. ||. |   . |. | .|   ..|...     . .|... .....    |.. .  |.  
qyvkalrkqRnamVqteeQYiFiheaileal....acgntevesenlkqhlqkLaeveedtemt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 62-187 4.8e-14 47.1 In-house 160-279 (288) alignment 
Range on Protein: 62-187
Range on HMM: 160-279/288.0
DVVLRTIEITsnfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQtpTVGLDYV
|.|||....       ||.  .| .| |..|  .. || ....|.. . |       .. ..|||| |.||.  |    .| .... ....  .  .| .
dfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtF....ialdalidavee..edyiDva

KLIQDLRSMRAGAIYTPMQLAFSIIMLLDFV
  .. ||  ||  . |  |  |   .||. .
gtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 62-185 1.4e-12 42.4 In-house 168-288 (298) alignment 
Range on Protein: 62-185
Range on HMM: 168-288/298.0
DVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS------KSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTPTVglDY
|.. |......   |........|.  .  |  .  || .. .|.. . ||.|      |.|.|.|| |.||. .|     | ....  ...  .|  | 
dlivrklkvsk...kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi....aidsvlervkkeqvv..Dv

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLD
 . .. ||  |.||. |  | .|   . |.
fqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 62-185 3.7e-12 41.0 In-house 120-240 (250) alignment 
Range on Protein: 62-185
Range on HMM: 120-240/250.0
DVVLRTIEITSNfskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDY
|.. |.. ....   .|..  ..|.. .  |  .  ||  . .|.. | |..|.       |.|.||.|.||. ||    .| .... ....  .|  | 
dytkrklklska...kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf....iaidavlerlkkekvv..dv

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLD
 |.|. ||  | .|. .  |  |   ..| 
fkvikvlrkdrphavesleqyvfvyeiilk
subfamily_PTPRA_pd Subfamily PTPRA 62-193 4.8e-12 40.4 In-house 170-303 (330) alignment 
Range on Protein: 62-193
Range on HMM: 170-303/330.0
DVVLRTIEITSNFS-KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTvgLDY
|. .| . ..     . .|..  .| . ...|     |  .. .|...|.|.| .     ..|||||.|.||. .|    .. ....  ..      .| 
dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtf....ivldavlervkaerk..vdv

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLENE--LS
 . .. ||  |.  . | .|  |   .||.. |  .  | 
fefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld
subfamily_PTPN3_pd Subfamily PTPN3 62-178 5.5e-12 40.2 In-house 154-266 (280) alignment 
Range on Protein: 62-178
Range on HMM: 154-266/280.0
DVVLRTIEITSnfsKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFAFTELAYQtmmLNMRQTPTVGLDYV
 .||| . ..    |..|| ..| .  |  |  .. |. | ..|.. . ||| .      ||||||.||||.  . . |.| .   |  .. |   || |
syvlrelvlkd...ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala...lieaaepvypldiv

KLIQDlrsMRAGAIYTPMQLAF
. ..|    ||  . |. |  |
rtmrd...qramlvqtasqykf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 62-189 1.5e-11 38.3 In-house 169-290 (302) alignment 
Range on Protein: 62-189
Range on HMM: 169-290/302.0
DVVLRTIEITSNFSKSkKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-KSVVVHCSTGIGRAAAFAftELAYQTMMLNMRQTpTvglDYVKLIQ
...| |.||. .  |. |  .|.    . .|     |. .   |...|      |.|.||||.|.||. ..    . |   .   ... |   | .....
sfklytveiknekkkk.kvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlv..aikyGiqlcskkkv.t...dllsivl

DLRSMRAGAIYTPMQLAFSIIMLLDFVLE
 .|. | ||. .  || . ....   ..|
pvrqcryGavqdeqqliylllcvtkglme
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 62-164 5.2e-06 20.8 In-house 119-220 (239) alignment 
Range on Protein: 62-164
Range on HMM: 119-220/239.0
DVVLRTIEItSNFskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVG-LDY
| ..||. . |.    . | . . .|..  |  .  |. .  .| . . . |     ..  |.|||.|.||. ||    |  ..|. . ..  ||  ..|
dyiirtfvm.sqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf....lvidamlrqakkqktvdifny

VKLIQDLRS
|| |.. | 
vkairedrp
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 62-164 5.7e-06 20.7 In-house 120-221 (239) alignment 
Range on Protein: 62-164
Range on HMM: 120-221/239.0
DVVLRTIEItSNFskSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVG-LDY
| ..||. . |.    . | . . .|..  |  .  |. .  .| . . . |     ..  |.|||.|.||. ||    |  ..|. . ..  ||  ..|
dyiirtfvm.sqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf....lvidamlrqakkqktvdifny

VKLIQDLRS
|| |.. | 
vkairedrp
subfamily_PTPRB_pd Subfamily PTPRB 63-188 2.5e-13 44.8 In-house 165-286 (293) alignment 
Range on Protein: 63-188
Range on HMM: 165-286/293.0
VVLRTIEITSnfsksKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDY
 |.|...|.      .||....|.| .. |   . || .. .|. ...||...        .||||| |.||. .|    .| .... ..... .|  | 
wvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtf....ialdrllqaieeedyv..di

VKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVL
. ....||. |.  . |  |  |    .||.. 
fgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 64-146 8.9e-07 22.7 In-house 157-244 (439) alignment 
Range on Protein: 64-146
Range on HMM: 157-244/439.0
VLRTIEITSNFSKSKKEtHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS------KSVVVHCSTGIGRAAAFAFTELAYQTMMLNMR
|.| . .  .  ...|| .|. .. |  |  .| |  .  .|. ..|.  .        ||||||.|.||. .    ..| . . |. .
virgfkvfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenk
subfamily_PTPRG_pd Subfamily PTPRG 66-206 1.3e-10 35.2 In-house 164-307 (563) alignment 
Range on Protein: 66-206
Range on HMM: 164-307/563.0
RTIEITSNFSKSKK---ETHTIRHYFYKGWIAQNGPELSREILNVF-KAVRKSKS----VVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYVK
||. |     | ||   . ...|.| |  |  .. || |   |.   |. .  |.    .|||||.|.||.  .    .. .|.. ...|  .|  .  .
rtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGty....ivldtllkqiqqenav..nvfg

LIQDLRSMRAGAIYTPMQLAFsiimLLDFVLENELSKETNIKYQQIRN-----S
... .|..|   . |  |  |    | | .||  .||||... .|...      
flkhiraqRnflvqteEqYif....lhdalleaiasketellaeqveelknctp
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 66-189 2.9e-09 31.4 In-house 154-273 (288) alignment 
Range on Protein: 66-189
Range on HMM: 154-273/288.0
RTIEITSNFS-KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNmrqtPTVGLdyVKLIQDLR
......     |  .|.  ...  .. |  .  ||     |.. . ...  | .|||.|.|.||....... .| ... |.      .|.   .|.. ||
klvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrld....dflgi..rsllaklr

SMRAGAIYTPMQLAFSIIMLLDFVLE
  |  || | ||  .   ..|. .| 
eerfkaiqtemqylyvhrcvleelll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 66-193 6.6e-08 27.0 In-house 164-290 (297) alignment 
Range on Protein: 66-193
Range on HMM: 164-290/297.0
RTIEITSNfskSKKETHTIRHYFYKGWIAQNGPE--LSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYVK
|..|.| .   . | .. .. | .  |  .. ..    . .|.. . |||.        ..|||..|.||.. .    |. . .. ..... .|  |  .
relevtkg...kakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl....ltidsvvaeakrekev..difg

LIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLENELS
|.. ||  |   . |  | .|   ..|...| ..  
lvkklrqerpylvqtkeqykfvyvavleallsedtr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 70-194 4.5e-12 40.2 In-house 175-296 (305) alignment 
Range on Protein: 70-194
Range on HMM: 175-296/305.0
IT-SNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTELAYQTMMLNmRQTPTVgldyVKLIQDLRSMRA
||  |.. | ... ..||  .  |  .  |      |... |.| ||  .|||||.||||. .    |   . .  | .. | .     .|.. ||  ||
itllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaen.kpcppm....pelvkalrdqra

GAIYTPMQLAFSIIMLLDFVLENELSK
 .| . .|  |   ..|...||.   |
fsiqndvqylfihrvmlnyflekykek
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 70-187 3.9e-11 37.6 In-house 158-276 (281) alignment 
Range on Protein: 70-187
Range on HMM: 158-276/281.0
ITSNFSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVR------KSKSVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTpTVGLDYVKLIQDLR
 . . .... || ....  |. |  .  |. ..|.|.  |.|.      .  ..|.|||.|.||. ..    .|  ... .. .. .  ||   ....||
rkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGty....ialDrlvkaveae.leeldvkavvaelr

SMRAGAIYTPMQLAFSIIMLLDFV
  |   . | .| .|   ..|| .
kernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 70-204 5.6e-10 33.6 In-house 150-279 (283) alignment 
Range on Protein: 70-204
Range on HMM: 150-279/283.0
ITSNFSKSKKETHTIRHYFYKGWIAQNGPELSREI--LNVFKAV-RKS--KSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTpTVgLDYVKLIQDLRS
.. . . | |.|  . || . .|.  .       .  .|  ..  ..|    .||||||||||.|.|     |  . . ...   .| .|  . .. .| 
lllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi....aasasvkdalte.sv.vdvfavvkimre

MRAGAIYTPMQLafsiIMLLDFVLENELSKETNIKYQQIR
 | .|. |  |      .. . |||. |  .|.| . .. 
qrmmavqtldqy....klvhelvleqalcgdtqiaavdlq
0048076 (Phosphotyrosine protein) phosphatases II 74-178 5.4e-15 50.8 In-house 37-134 (145) alignment 
Range on Protein: 74-178
Range on HMM: 37-134/145.0
FSKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK----SKSVVVHCSTGIGRAAAFAFTELAYQtmmlnmrqtptVGLDYVKLIQDLRSMRAGA
 |  . ..... .|.| .|   . |.|.. .|........     . |.|||| |.||.....   | ..            |... . .. .||.| ||
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll...........lgvsleealelvrsqrpga

IYTPMQLAF
...| || |
vpnpgqlrf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 75-199 9.4e-15 49.4 In-house 169-287 (307) alignment 
Range on Protein: 75-199
Range on HMM: 169-287/307.0
SKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-KSVVVHCSTGIGRAAAFAFTELAYQTMMlnmrQTpTVGLDYVKLIQDLRSMRAGAIYTP
 .  ... ||.|. .. |  .  |..    .|...|||     ||||||.|.||. .     |  . |.    .      |  ||...||| |  || | 
vdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmi....aG.inckdmkklveelrsqrhyaiqte

MQLAFSIIMLLDFVLEneLSKETNIK
.|  .   .||.. ||  | |||  .
aqylylhrvlleyfle..lyketyee
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 75-195 5.9e-13 43.4 In-house 160-278 (285) alignment 
Range on Protein: 75-195
Range on HMM: 160-278/285.0
SKSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK----SKSVVVHCSTGIGRAAAFAftELAYQTMMLnMrQTPTVglDYVKLIQDLRSMRAGAI
  .  |   . |     |  |  || .| .....| |.|     | ..||||.|.||.|.|    . | |. . | . | .  . . .....|.||  |.
edasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfv..gidyatiri.m.enpni..emldivremramrfqav

YTPMQLAFSIIMLLDFVLENELSKE
 . ||. |  ..|..... . . . 
qshmqflflyvvlmeyfigegvver
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 75-196 3.7e-07 24.0 In-house 169-288 (303) alignment 
Range on Protein: 75-196
Range on HMM: 169-288/303.0
SKSKKETHTIRHYFYkGWIAQN-GPELSREILNVFKAVRK---SKSVVVHCSTGIGRAAAFAFTELAYqtMMLNMRQTptvGLDYVKLIQDLRSMRAGAI
 ||    |  . . . . |  .  |.. ..| ..   .||   |.  |    .| ||| .||. | |.  . |   |.    || || .. .|  |  |.
yksflhvhhykawph.nsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah..lslhseqa...sldlvkclenvrngrlhav

YTPMQLAFSIIMLLDFVLENELSKET
    |...   .| . ||.| ..| .
qnlsqfsvvytllaehvldngickla
subfamily_PTPN1_pd Subfamily PTPN1 76-186 1.3e-15 51.9 In-house 156-270 (290) alignment 
Range on Protein: 76-186
Range on HMM: 156-270/290.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-------VVVHCSTGIGRAAAFAFTElayqTMMLNMRQTPT-VGLDYVKLIQDLRSMRA
.. .||..| |. |  |     ||     |. .  ||.| |       .|.|||.||||. .|.. .    |..... ..    ..|  | . .||..| 
lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvd....tclvliekkddlssvdikkvllelrkyrl

GAIYTPMQLAFSIIMLLDF
| | |. || || . .|. 
GliqtadqlrfsylaileG
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 76-178 7.7e-13 43.1 In-house 155-259 (274) alignment 
Range on Protein: 76-178
Range on HMM: 155-259/274.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK--------SVVVHCSTGIGRAAAFAFTELAYQtmmlNMRQTPTVglDYVKLIQDLRSMRA
|. ...... ||.|  |  .. |.  ...|.. . |..|.        .|||||| ||||. .|  ...| .    ..|.. .|  | .|.. .||  | 
kylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavr....qlreeivv..dvlkivcnlrldrG

GAIYTPMQLAF
| . |  |  .
Gmvqtseqyel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 76-209 6.6e-08 26.8 In-house 167-295 (315) alignment 
Range on Protein: 76-209
Range on HMM: 167-295/315.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAftelAYQTMMLNMRQTPTVglDYVKLIQDLRSMRAGAI
.  .|..|.  . ...|  .  .. .  .|.. |.|. .      |..||||.|.||.  .     . . .. ....| .|  |  .... ||. |   .
rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi....sidevvaqikrtrsv..dvfnfvknlrakrpylv

YTPMQLAFsiimLLDFVLENELSKETNIKYQQIRNSYLD
 |  . ||    . | |||. | ..| |.  .. .   |
qteeeyaf....iydavledllwrntlilvihftdhlqd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 76-198 7.9e-08 25.8 In-house 167-283 (515) alignment 
Range on Protein: 76-198
Range on HMM: 167-283/515.0
KSKKeTHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-----SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTVglDYVKLIQDLRSMRAGAI
|... ..|.  . ...|  .  |. .. .| . |.|. ..     ....|||.|.||.  .    .. . .. ....| .|  |  .... .|  |   .
kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv....isidsvvahakttrmv..dvfnfvtnirqkrpylv

YTPMQLAFsiimLLDFVLENELSKETNI
 |  | ||    . . |||. | ..| |
qtqeqyaf....iygavledllwrntli
subfamily_PTPN23_pd Subfamily PTPN23 76-184 6.3e-07 23.5 In-house 165-277 (288) alignment 
Range on Protein: 76-184
Range on HMM: 165-277/288.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK---------SKSVVVHCSTGIGRAAAFAFTELAYQTMmlnmRQT---PtvglDYVKLIQDLR
..........|  .. |     |.   ..|.....|..          . .|||||.|.||. .||    | . .    ..    .    | ..... ||
ldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel....ekgngll....diiqvvsrlr

SMRAGAIYTPMQLAFSIIMLL
  |   . .  || ||  . |
eqRrfmvqekeqlkfsyeavl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 76-190 4e-06 21.0 In-house 169-282 (315) alignment 
Range on Protein: 76-190
Range on HMM: 169-282/315.0
KSKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS-----KSVVVHCSTGIGRAAAFAftELayQTmMLNMRQTPTvGLDYVKLIQDLRSMRAGAI
 .... ...  . |  |   . |. .  ..|... |..       ..||||| |.||. .|    |  .. .|.  ..    .|  ..|. .|..| ...
vfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfi..tl..da.vldqaeaen.aidvynfitgvrqnrikmv

YTPMQLAFSIIMLLDFVLEN
 .  |  |   .||. ..  
qvaeqyqfiydalletfvcg
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 77-196 9.5e-12 39.2 In-house 181-296 (305) alignment 
Range on Protein: 77-196
Range on HMM: 181-296/305.0
SKKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSKS-VVVHCSTGIGRAAAFAFTELAYQTMmLNMRQTPtvglDYVKLIQDLRSMRAGAIYTPMQ
. .... . || .  |  .  |     ||....  | ||  .|||||.||||. .  . |   . . |. ..      |  |..| .|  |  .| |  |
pgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildql.lagqiie....dtdkilqkireqrnnsiqtdaq

LAFSIIMLLDFVLENELSKET
  |   ..|.......| .|.
ylfvhqvilnyfrkkklldee
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 77-183 1.1e-11 39.2 In-house 147-260 (270) alignment 
Range on Protein: 77-183
Range on HMM: 147-260/270.0
SKKETHTIRHYFYKGWIAQNGPE------LSREILNVFKAVRKSK-------SVVVHCSTGIGRAAAFAFTELAYQTMMLNMRqtptvgLDYVKLIQDLR
.| |.. . |..|. |  .  |.       ....|....|||.|.        ..|||| |.||.  .  .. | ...  ...      .| ...|..||
ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkk......vdvlaiieelR

SMRAGAIYTPMQLAFSIIML
  |   . .| | .|    .
kdRmalvqhpeqyeflykav
subfamily_PTPRN_pd Subfamily PTPRN 78-182 1.1e-10 35.7 In-house 183-287 (297) alignment 
Range on Protein: 78-182
Range on HMM: 183-287/297.0
KKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRK-----SKSVVVHCSTGIGRAAAFAFTELAYQTMMLNMRQtptvgLDYVKLIQDLRSMRAGAIYT
..|| |.  . .  | ... |  .. .|.  . | |     | ..||||| | ||. ..   .|  . ..  ...     .| .  .. ||  |.| . |
tsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvke.....idiaatlehlrdqrpglvkt

PMQLAFSIIM
  |. | .  
kdqfefalta
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 78-203 1.7e-08 28.2 In-house 85-206 (440) alignment 
Range on Protein: 78-203
Range on HMM: 85-206/440.0
KKETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK------SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQTPTvgLDYVKLIQDLRSMRAGAIY
  |..|...|.|.||  .  |...  .|.. . | .|.       ..||||.| ||..      .| .... . ...    .| . .|. .|. |   . 
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgvi....iavdsilreakrsdq..idifsfinsmrnnrpqmvq

TPMQLAFSIimllDFVLENELSKETNIKYQQI
|| | ||      . |||  |. .| |  ..|
tpeqyafvh....eavlegllcgdtlileddi
0048179 (Phosphotyrosine protein) phosphatases II 79-178 8e-14 47.1 In-house 44-136 (144) alignment 
Range on Protein: 79-178
Range on HMM: 44-136/144.0
KETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKS----KSVVVHCSTGIGRAAAFAFTELAYqtmmlnmrqtpTVGLDYVKLIQDLRSMRAGAIYTPM
 ..... .|.. .|   . |.|.  .|........     . |.|||| |.||.....   | .           . ||.. . .. .||.| ||...| 
fleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...........klglsleealalvrsrrpgavpnpg

QLAF
|| |
qlrf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 80-217 1.9e-10 34.9 In-house 174-306 (312) alignment 
Range on Protein: 80-217
Range on HMM: 174-306/312.0
ETHTIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-SVVVHCSTGIGRAAAFAFTElayqTMMLNMRQTP--TVGLDYVKliqdLRSMRAGAIYTPMQL
.   . || .  |  .  |.     | .. ||.| |  |. |||.|.||. ..|. |    .|.  .|.     |   .|     ||  || .. .  | 
qesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlalie....smiaalrhprkqnvkdsfvl....lrkdrarsvrvfpqy

AFSIIMLLDFVLENELSKETNIKYQQIRNSYLDLRKRKYRT
 ...  .|.|.  . | |  . .. .....|  .. .| . 
vyalrcvleflyskglykrneqewtkfketyakikakklki
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 81-184 5.2e-06 20.4 In-house 167-274 (287) alignment 
Range on Protein: 81-184
Range on HMM: 167-274/287.0
THTIRHYFYKGWIAQN-GPE---LSREILNV---FKAVRKSK---SVVVHCSTGIGRAAAFafteLAYQTMMLNMRQtpTVGLDYVKLIQDLRSMRAGAI
.. .. . .  | ..   |    | | .|.|    .. |...    .|||...||||.  .    ||  ...  . .  .  .|  . .  ||  ||. .
arvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil....latlvlvsrled..lGrvdvaavvirlreyraalv

YTPMQLAFSIIMLL
 ...|| ...  | 
qavvqlrllyealv
PTPc_DSPc_SM00012 83-184 1.5e-17 59.1 In-house 1-104 (105) alignment 
Range on Protein: 83-184
Range on HMM: 1-104/105.0
TIRHYFYKGWIAQNGPELSREILNVFKAVRKSK-------SVVVHCSTGIGRAAAFAFTELAYQTMMLNMrqtptVGLDYVKLIQDLRSMRAGAIYTPMQ
|..|| |.||  .. || | .||....||.|.|       .||||||.|.||.. |.  ....| .. .        .|  .... ||..|.|.. | .|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.....kevdifqivkelrkqRpgmvqteeq

LAFSIIMLL
  | . .||
ylflyrall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 86-196 4.4e-06 20.3 In-house 189-294 (302) alignment 
Range on Protein: 86-196
Range on HMM: 189-294/302.0
HYFYKGWIAQNGPELSREILNVF-KAVRKSKSVVVHCSTGIGRAAAFAFTELAYQTmmLNMRQTPTVGldyvKLIQDLRSMRAGAIYTPMQLAFSIIMLL
..  .  . ..  || ... .|| | .  ....|.    |.|||.||    .| ..  |.  . | .      ... .|| |. |. .  | ..  |.||
tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavek..lqkgkepnik....eivksiRsqRpravdslkQyvslyiall

DFVLENELSKET
 .....  . |.
lyikkkvtkpee
subfamily_egg_pd Subfamily egg 104-202 9.4e-07 22.8 In-house 190-286 (307) alignment 
Range on Protein: 104-202
Range on HMM: 190-286/307.0
ILNVFKAVR-KSKSVVVHCSTGIGRAAAFAFTELAyqtMMLNMRQtPTVGLDYVKLIQDLRSMRAGAIYTPMQLAFSIIMLLDFVLE-NELSKETNIKYQ
 |.|.. .|  || |||..  |. .||..   |.|   ..  .|  |..     . .. ||  |  .. ....  |   ..| |. .    .|| .. |.
plrvlrklrnlskpvvvqdilGvskaatlvaieia...llsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdye

Q
.
r
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 111-163 9.6e-06 19.5 In-house 259-312 (350) alignment 
Range on Protein: 111-163
Range on HMM: 259-312/350.0
VRKSKSVVVHCSTGIGRAAAFA-FTELAYQTMMLNMRQTPTVGLDYVKLIQDLR
  .|....|||| |.||.  .  .  |  .. .|.. .   . ||. . ..|| 
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli
subfamily_CG42327_pd Subfamily CG42327 116-180 7.3e-06 19.9 In-house 249-308 (319) alignment 
Range on Protein: 116-180
Range on HMM: 249-308/319.0
SVVVHCSTGIGRAAAFAFTELAYQTMmlnmrQTPTVGLDYVKLIQDLRSMRAGAIYTPMQLAFSI
 .||||| |.||.     ...| ...     ...   .|  .|.. .|  || |. |  | .|  
PlvvhcsdGvGrtGlviasdiairsl.....eeskrsvdiPqlvssvrrdrasavltkeqyefiy