Gene ida-1 in Caenorhabditis elegans

Synonym: CELE_B0244.2, ida-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP113_AA protein Get Run
CeleP113_AA_484-758 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 471-760 2.9e-58 193.0 In-house 3-292 (297) alignment 
Range on Protein: 471-760
Range on HMM: 3-292/297.0
WCEETAVPTIDISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEeRTKTKAEKFASQNRT--ILPFDDNIVDIDGKTAE-NEDFYLNASFIYDDDPRQA
.........|.|..... | .| | ....|......  ....  . .. .. ..  . ||   |||.|.. | . ..    ... | |||..   | .. 
plrdallesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

VYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ-EKNYWPDTGSeVHGAFEIHLVSEHIwSDDYLVRSFYLKNlqNSQTRTITQFHYLSWQKES
 .||.|.| .. .. ||. .|..||  .|.| ...|...    |||..|. ..| | ..|....   |.| || . ..|  |...||.|.|.|..|   .
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhg

TPTSAKSILEFRRKVNKSYRG--RSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHL
.| |....||| ..|.. ..   ..  ||||. .| ||||...| . .. .| .. ...||  .|..|| || |.| | .|.. .| .... ... 
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRN_pd Subfamily PTPRN 472-762 1.1e-154 508.4 In-house 1-297 (297) alignment 
Range on Protein: 472-762
Range on HMM: 1-297/297.0
CEETAVPTIDISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEERTK--TKAEKFASQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQA
.||..|...|||||||||..|...|......|..|.....|..|..||  .||||....||  ..||.|...|... ........|.|||.|.|.|||..
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

VYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEE--CKQEKNYWPDTGSEVHGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKE
.|||.|.|..|..|.|||..|..||...|||.. ||  .||.|.||||.||||....|.||||||||.||||||||||||||.|.|||.||||.|||..|
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

STPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLK
..|.||||.|||||||||||||||....||..||.||||||...|....|||.|...||..||.|||||||.|.|.| |||......||.|||..||
gvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk
0045450 (Phosphotyrosine protein) phosphatases II 481-754 1.6e-55 184.4 In-house 8-301 (307) alignment 
Range on Protein: 481-754
Range on HMM: 8-301/307.0
DISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNE-----ERTKTKAEKFASQNRTILPFDDNIVDIDGKTAE-NEDFYLNASFIYDDDP-------RQA
 |.. . .| .|.. |. .|....... ....  .     . .. .. |   . . |||.|.. | .   . . ... | |||.......       .. 
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

VYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGSE-VHGAFEIHLVSEHIwSDDYLVRSFYLKNL-QNSQTRTITQFHYLSWQ
 .||.|.| .. .. ||. .|..|| ..|.|....|...||   ||||.|.| ..| | ..|.||..  |.| || . ...| .....||.|.|||..| 
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwp

KESTPTSAKSILEFRRKVNKSYRG--RSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQ--IDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
  ..|.| ...|.| ..|.| ..   ... ||||. .| ||||...| .... .| ..     .|.  .|..||.|| |.| . .|.. .| ...
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall
0043336 (Phosphotyrosine protein) phosphatases II 482-754 1.9e-58 193.5 In-house 2-274 (278) alignment 
Range on Protein: 482-754
Range on HMM: 2-274/278.0
ISTGHVVLNFLQEYLSEPTKIEAQWNGIKDYRNEERTKTKAEKFASQNRT--ILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQ
||. . .  .|. .|...|......  . ..  .... .. ..  . ||.  |||.| . | ..  . .. . | |||.. |  ...  .||.|.| .. 
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlpet

IAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPdTGSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEF
.. ||. .|..||  .|.| ...| ...|   |||  ||...| | ..|..|.   ||| || . ..||.....||.|..|||.|   ..|.| ...|.|
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

RRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIrQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
 ..|.. .. ....||||. .| ||||...|...|. .| ..   .|.  .|..|| || |.| | .|.. .| ...
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPN23_pd Subfamily PTPN23 488-761 7e-41 134.9 In-house 3-284 (288) alignment 
Range on Protein: 488-761
Range on HMM: 3-284/288.0
VLNFLQEYLSEPTKIEAQWNGIKDYRNEE---RTKTKAEKFASQNRT--ILPFDDNIVDIDgktaENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAA
| .  ...|.. |....... .... ..|   |. . |......||   |||.| | | ..    ...| |.||||. |  |    .||.|.|  | .. 
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnD

FWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTG--SEVHGAFEIHLVSEHiWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFR
||. ...  . ..| | ..|| ...  ..|||     ....|.... | |..  .. .  | . |. |.........  .. || .   | | ...|.| 
FWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfl

RKVNKSY---RGRS-SAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLL
 .|...|   . .|   ..||   |.|||||.. |    . | .|   .|..  |..|| ||  || . .|.| .|  | ..... |
devesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
0040438 (Phosphotyrosine protein) phosphatases II 490-757 6.3e-60 198.4 In-house 8-276 (317) alignment 
Range on Protein: 490-757
Range on HMM: 8-276/317.0
NFLQEYLSEPTKIEAQWNGIKDYRNEERTKTKAEKFASQNRT--ILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTI
  |. ..|  |... ... . ..  .... .. ..  . ||   |||.|.. | .   .  ... | |||.. |   ..  .||.|.| .. .. ||. .
alldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmv

WQHGVCLVVNLSTPEECKQEK--NYWPDTGSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSY
|..||...|.| ..||...||   |||. .. ..| | ..|.||.   ... .| . ...|..|..||.|.|||..|   ..| | ...|.| ..|....
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

RGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIrQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
..... ||||. .| ||||...|..... .| ..  ..||  .|..|| || |.| | .|.. .| .... .
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleyl
0050432 (Phosphotyrosine protein) phosphatases II 491-759 1.1e-61 204.2 In-house 31-301 (308) alignment 
Range on Protein: 491-759
Range on HMM: 31-301/308.0
FLQ--EYLSEPTKIEAQWNGIKDYRNEER-TKTKAEKFAS--QNRTILPFDDNIVDIdgktaENEDFYLNASFIYDDD-PRQAVYIAAQTPASSQIAAFW
.|.  | . .....|.... . .. . .  . .. ..  .  . . |||.| . | .     .... | |||..   .  ..  .||.| | .. .. ||
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

QTIWQHGVCLVVNLSTPEEC--KQEKNYWPDT---GSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRR
. .|...| ..| | ...|   ..   |||..   ||...| | ..|.||..  ||| || ..|.||.....||.|.|||..|   ..|.|....|.| .
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

KVNKSYrgRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNH
.|.||.  ... ..||. .| ||||...|.|.|. .| .. . .||  .| .|| || ||| | .|....| ...  .. 
lvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0051299 (Phosphotyrosine protein) phosphatases II 491-754 1.4e-59 197.2 In-house 14-283 (288) alignment 
Range on Protein: 491-754
Range on HMM: 14-283/288.0
FLQEYLSEPTKIEAQWNGIKDYRNE---ERTKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTI
.|. ... .|....... . ..        .. .. .   ... |||.|.. | .     .... | |||.| |  ...  .||.|.| .. .. ||. .
vlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqgPlpntvedFWrmv

WQHGVCLVVNLSTPEECKQ--EKNYWPDTGSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNL----QNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKV
|...| ..| | ...| ..     |||. ||...| . ..|.||..  ||| || ....||    .....||.|.|||..|   ..|.|....|.| |.|
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

NKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
.|... ... |.||...| ||||...|.|.|. .|... . .||  .|..|| || ||| | .|...|| ...
rkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyeall
Lipoprotein_10 Putative mycoplasma lipoprotein, C-terminal region 491-554 8.5e-06 12.3 Pfam-A 24-83 (135) alignment 
Range on Protein: 491-554
Range on HMM: 24-83/135.0
FLQEYLSEPTKIEAQWNGIKdyRNEERTKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDfyL
|.. .| . .. |.. .| |  ......|| || || .   |||. ... . ..|. |..|   
FvnWflnkevtweekekgkk..ksdqkkktaAeyfaesasYilPlkekfekskkkeseskd..k
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 494-759 2.6e-44 146.6 In-house 16-285 (305) alignment 
Range on Protein: 494-759
Range on HMM: 16-285/305.0
EYLSEPTKIEAQWNGIKDYRNEER-TKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGV
.   . ...|||.. . .  .    .|..|.| ..... | ..||. . .  |  ...  |.|||.. |   |.  ||.||.|  . .| ||..|..  |
arvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyv.dgykrkkkyivaqgPlkntvadfWrliveekv

CLVVNLSTPEECKQE--KNYWPDTGSE--VHGAFEIHLVSEHIWSdDYLVRSFYLKN-LQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG
  .| |.   | ...  . |||.. .|   .| |...| ||.  | ||. | . . .  .....||..|..  .|  .  |..| |.|.. ..|.|... 
stivmltklveggkdkCrqYWpesktekkefgefsvelksektas.dyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

-RSSAVLVHSWDGSGRTGVYCAVDVLCARLLRgIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNH
 .  ..|||  .| |||||..|||.   || .   ..||   . .|| .| .|| | ||.  ..  ...... 
dkgvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 497-758 8.2e-47 154.8 In-house 20-284 (319) alignment 
Range on Protein: 497-758
Range on HMM: 20-284/319.0
SEPTKIEAQWNGIKDYRNEERTKTKAEKFASQNRT--ILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCL
.  |..| ... .|   |.. .... |.  ..||   ||..|   | .      ..  |.|||||   . ..  .||.|.| .  |  ||. .|....  
tgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessi

VVNLSTPEECK--QEKNYWPDTGSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQ-TRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG-RSS
|| |.   |    . |.|||..  |. | . . | .|.   .|| .| . |.....   ||....|.|..|  .  |..|.|.|.. ....|| ..  | 
vvmltklveklkvklkkywpeenfeeyGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

AVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVN
 . ||  .|.|||| ....|.   |. .    .||  || .|| ||. || . .|.|..|  . . |.
PivvhCsaGvGRtGtfivldamlervkee.gvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0047943 (Phosphotyrosine protein) phosphatases II 500-754 2.7e-57 189.7 In-house 12-269 (273) alignment 
Range on Protein: 500-754
Range on HMM: 12-269/273.0
TKIEAQWNGIKDYRNEER-TKTK--AEKFASQNRTILPFDDNIVDIdgktAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVV
|....... .... ..   . ..  . |   ... |||.|.. | .     .... | |||.. |  ...  .||.|.| .. .. ||. .|...| ..|
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

NLSTPEECKQ--EKNYWPDTG---SEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG--RS
 | ...| ..     |||..|   |...| | ..|.||..  ||| || ..|.||.....||.|.|||..|   ..|.| .|.||| ..|.| ..   ..
mLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

SAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
. |.||...| ||||...|.|.|. .| .. ...||  .| .||.|| ||| | .|....| ...
gpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyeall
subfamily_PTPRD_pd Subfamily PTPRD 500-762 3.9e-55 182.5 In-house 23-286 (564) alignment 
Range on Protein: 500-762
Range on HMM: 23-286/564.0
TKIEAQWNGIKDYRNEERTKTKAEKFASQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVN
.|.| ... |.  .... .. ...   . ||   |...| . | .    ....  | |||||   . ..  |||.| | .. |. ||. .|.. .. .| 
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVm

LSTPEECKQEK--NYWPDTGSEVHGAFEIHLVSEHIWsDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVH
|.  || ...|  .|||..|.| .| ... |..|.    || .|.| ||. ..|..|...|||. ||  .  |.||.|.|...|||... .  .  ..||
ltkleEkgkvkchkYWPekgtetygeltVtleeeeel.adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVh

SWDGSGRTGVYCAVDVLCARLLRgIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLK
   | ||||.....|..  |.    ...|.  .|..|| ||. || | .|.  ..  ... ..   .
CSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 500-754 5.6e-26 85.9 In-house 15-290 (301) alignment 
Range on Protein: 500-754
Range on HMM: 15-290/301.0
TKIEAQWNGIKDYRNEERT--KTKAEKFASQNRTILPFDDNIVDIDGK--TAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLV
.|.|.|.. .|...... |   ....| ..... | ..||| . .  |      .  |.|||.| |.  ..  .|||| |  . .. ||. |||. .  .
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyi.dgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VNLSTPEECKQ--EKNYWPDTG--SEVHGAFEIHLVSEHIWSdDYLVRSFYLKNL---------------QNSQTRTITQFHYLSWQKESTPTSAKSILE
| .   .|...   ..|||..   ||  | |.. ||.|...  |...|.. .|                 .. ......|..  .| ..      . .|.
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyP.dfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLq

FRRK-VNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
   . . .  .   . |.||  |. .|.||||.|..      .    .||.  .. .| .. |.| | .|.  .|  . 
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
DSPc_SM00195 503-757 1.3e-60 200.3 In-house 3-262 (263) alignment 
Range on Protein: 503-757
Range on HMM: 3-262/263.0
EAQWNGIKDYR-NEERTKTKAEKFASQNRT--ILPFDDNIVDIDGKTAENEDFYLNASFIYDDdPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLS
... . ..... ..| |... .|  |.||   |||.|.. | .. .  .... |.||..|  .  ..  |||.| | .|... ||...|...| ..| |.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

TPEECK--QEKNYWPDT--GSEVHGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVH
 .||..  . ..|||..  |.|..| ....||.... .|.. .| . |.. ....||..||..| .|.....| |.||.||. |.|.||..  |. ..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

SWDGSGRTGVYCAVDVLCARLLRGIRqIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
. .| ||||.....|... .| .. . .|. ..|..||.|| ||| | .|.. .| .... .
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 503-757 1.3e-60 200.3 In-house 3-262 (263) alignment 
Range on Protein: 503-757
Range on HMM: 3-262/263.0
EAQWNGIKDYR-NEERTKTKAEKFASQNRT--ILPFDDNIVDIDGKTAENEDFYLNASFIYDDdPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLS
... . ..... ..| |... .|  |.||   |||.|.. | .. .  .... |.||..|  .  ..  |||.| | .|... ||...|...| ..| |.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlt

TPEECK--QEKNYWPDT--GSEVHGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVH
 .||..  . ..|||..  |.|..| ....||.... .|.. .| . |.. ....||..||..| .|.....| |.||.||. |.|.||..  |. ..||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

SWDGSGRTGVYCAVDVLCARLLRGIRqIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
. .| ||||.....|... .| .. . .|. ..|..||.|| ||| | .|.. .| .... .
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 503-754 4.1e-36 119.7 In-house 17-266 (273) alignment 
Range on Protein: 503-754
Range on HMM: 17-266/273.0
EAQWNGIKDYRNEERTKTKAEKFASQNRTILPFDDNIVDIDGKTAenedfYLNASFIYD-DDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTP
  . . .|   . | .|.|..| . . | .||.|.  | ......     |.|||.|    .  . .|||.| |    .. ||| .|.  . ... ... 
fkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

EECKQE--KNYWPDTGS---EVHGAFEIHLVSEhIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRgRSSAVLVHS
 | ..   . |||.. .    |.. .|..|.      |.. ||.. .|... ...| ...... .|   ..|.||...|.| ..|..  .  .. ..|| 
kekgkvkchrywPesknkklkvsnrlevellkv.qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhc

WDGSGRTGVYCAVDVLCARLLRgIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
  | ||.|.. ..||.   . |  ...||  .|..||.||.|.| | ||. .||  . 
saGiGrsGtlitidvvlglier.dkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_PTPN12_pd Subfamily PTPN12 504-764 1.2e-52 173.6 In-house 22-284 (290) alignment 
Range on Protein: 504-764
Range on HMM: 22-284/290.0
AQWNGIKDYRNEertKTKAEKFASQN--RTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTP
...   | |..|   ....|.   .|  . |||.| . | .  .. |... |.||.||   .  .  |||||.| .  .  ||. ||.. | .|| .   
ekykaekvyste...agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCre

EECKQEK--NYWPDTGSEV--HGAFEIHLVSEHIWSDDYLVRSFYLKnlQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSW
 | .. |   |||..| |   .|.||. | .|.  .||.|.|.. ..  .....|...|||| .|    .|.||||.||. ..|..  .  .. ..||  
velgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkve..aqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCs

DGSGRTGVYCAVDVLCARLLRGIR--QIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLKSI
 | ||||. .|.|     | ...   ..||   | .|| ||  .| | .|..||| .||. |.. |..|
aGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
subfamily_PTPN14_pd Subfamily PTPN14 506-757 1.3e-36 121.2 In-house 29-296 (300) alignment 
Range on Protein: 506-757
Range on HMM: 29-296/300.0
WNGIKDYRNEERTKT-KAEKFASQN--RTILPFDDNIVDIDGkTAENEDFYLNASFIY-DDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTP
.. |.  |..  ..| | .. |..|  . .||..|| |..   | ||.. |.||| |      ..  ||.||.|    .  ||| .|..|| |.| |   
yeripkkredallstaklpenaeknrfkdvlPyednrvelsp.tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

EECKQEK--NYWPDTGSE-VHGAFEIHLVSEHIW--SDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNK-------SY--RG
||  .||  .|.|...|.  .  |. . |...    || .  ... || |  .. ||.  . |  | ..  |   |. |.. ..|.        .   . 
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

RSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
..  ||||  .| |||||   .|.| | |  . ..||.  ....|| ||. .|.|  |.| ||  . . .
skPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 507-761 3e-43 142.9 In-house 22-280 (281) alignment 
Range on Protein: 507-761
Range on HMM: 22-280/281.0
NGIKD-YRNEERTKTKAEKFASQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEE
.....  ...  | .||..   .||   |  .|   | .  . ....  |.||.|.   .  .. |||.|.|  . ..|||| .|.. |...| .    |
eklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie

CKQEK--NYWPDTGSEVH-GAFEIHLVSEHiWSDDYLVRSFYLkNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRS-SAVLVHSWDG
  . |   ||||  ||.. | . .. ..|.  .  |. | | | . ....||...|..|..|     |...| .||||..|.|  . ..  ....|   |
agklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaG

SGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLL
 ||||.| |.| |. .. .  ...|| |.|..|| .|  || |  |.. ||  | . ... |
vGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPRB_pd Subfamily PTPRB 507-757 1.1e-41 137.8 In-house 32-285 (293) alignment 
Range on Protein: 507-757
Range on HMM: 32-285/293.0
NGIKDYRNEERTKT---KAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAvYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEE
. .|.  ... .|.   ....   . . |||.| . | .   . |... |.||..| .   ..  .||.| |  . .  ||. .|.. .  .| |    |
eelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspre.fiatqGPlpetvddfWrmvwekkssiivmltqlve

CKQEK--NYWPDT-GSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNlqNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSY--RGRSSAVLVHSWD
  ..|  .|||..  . ..|  ...||.|.   .|. .|.. ...  ....|...|.|..||     | ..|..|.| |.|...     ... ..||   
kgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsa

GSGRTGVYCAVDVLCARLLRgIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
| ||||.. |.| |  .. .    .|....| .|| .|  .| | .|.  .. || . .
GvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPRG_pd Subfamily PTPRG 511-755 1e-38 127.9 In-house 35-285 (563) alignment 
Range on Protein: 511-755
Range on HMM: 35-285/563.0
DYRNEERTKTKAEKFASQNRTILPFDDNIVDIDGKTAENED-FYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLST--PEECKQE
.. . | .. . .|    .  |...|   |.. . . ....  |.||..| |   ..  .||.| |  . .  ||. ||.. | ..| ..    .. ...
kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyi.dGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkc

KNYWPDTGSEVHGAFEIHLVSEHIWSdDYLVRSFYLKNL-----QN-SQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSG
. |||  .||  ||... |..|.. .  | ||.. .|||     ..  . ....|.|| .|   ..|...   | | .| ... .     ..||   | |
dvYWPkdesetygalqvtlieeevla.lytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvg

RTGVYCAVDVLCARLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
|||.|...| |  .. .   ...|  .. |.| ||. .|.| .|.  ..  . .
rtGtyivldtllkqi.qqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 513-755 4.7e-48 158.7 In-house 35-277 (288) alignment 
Range on Protein: 513-755
Range on HMM: 35-277/288.0
RNEERTKTKAEKFASQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTP-EE-CKQEK
.... |...  . |..||   |||.| . | ...   |..  |.|||.| |.. .. .|||.|.|  . .  ||. .... .  .| |.   |.  .. .
ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyi.dgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

NYWPDTGS-EVHGAFEIHLVSEHIwSDDYLVRSFYLKnlQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYC
.||||..  . .| ... ||...   .|...|.. |.  .. . ..|||..||.|  .. | |.. .||..|.|. .    .  ..||  .| ||||.. 
eYWPdadkpknyGsvtvtlveske.ledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFi

AVDVLCARLLRgIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
|.| |  .. .   .|||..||..|| ||  .| |  |.  .| ....
aldalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 513-758 1.6e-39 130.6 In-house 35-279 (287) alignment 
Range on Protein: 513-758
Range on HMM: 35-279/287.0
RNEERTKTKAEKFASQNR--TILPFDDNIVDIDgktaENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--
|..| | . |..   .||   ||. |.. | .     .... |.||.||      .  .|.|..| .. .  ||. |... |  .| |.  .| ..|.  
redevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcy

NYWPDTGSEVHGAFEIHLVSEHiWSDDYLVRSFYLKNLQ-NSQTRTITQFHYLSWQKES-TPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVY
.|||.. | | | ..|.|..|.  ...|..| . .|| . ........|... .|...   .. . ..| . ... . ..   ....||  |. ||....
qyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamf

CAVDVLCARLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVN
||...   .  .    |||.  ... | |. |.| | .|.| ..  | . ..
caaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 513-602 7e-06 19.8 In-house 36-120 (347) alignment 
Range on Protein: 513-602
Range on HMM: 36-120/347.0
RNEERTKTKAEKFASQNRTILPfDDNIvdiDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPE
.. .. ..|  |.  . | .|   ..    .   |.. . |.||| |  |.  .  || .| |  . .  ||. .    |  || .  | 
kslsknrskdvklidatrvvls.peks...knsraddvetyinashikfdn.askeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 515-755 2e-48 160.1 In-house 46-288 (298) alignment 
Range on Protein: 515-755
Range on HMM: 46-288/298.0
EERTKTKAEKFASQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQaVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNY
|| . .....  ..||   |...|   | .  . |..|  |.||||.   . |.  .||.|.|  . .. ||. .... .  .| | . || ..   ..|
eekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhky

WPDTGSEVHGAFEIHLVSEHIWSdDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRS-SAVLVHSWDGSGRTGVYCAV
|||.|.| .| ....| |..  . |. || . ... .....|.. |.|. ||  ...|. |.|.|...|||..| .    ..|.|.  .| ||.| ..|.
wPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiai

DVLCARLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
| .  |. .  . .||  .|. || .| |.| | .|.. .|  | .
dsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_PTPN1_pd Subfamily PTPN1 516-759 1e-32 108.0 In-house 25-273 (290) alignment 
Range on Protein: 516-759
Range on HMM: 25-273/290.0
ERTKTKAEKFASQNRTILPFDDNIVDIDgkTAENedFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPD
. .|.....   . | . |.|   . ..   |.|   |.|||..  ..  .  || .| | .. .. ||| .|..    || |    | .| |  .||| 
reaklpenrnlnryrdvspydhsrikle..radn..dyinaslvelee.akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

TGS--EVH---GAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSY--RGRSSAVLVHSWDGSGRTGVY
  .  |.      ....|.||.. .. | || . |.||.  .||.|..|||..|   . | |  . |.|  || .|         ...|   | ||.| .
geeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

CAVDVLCARLLRGI--RQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNH
| || . ... .      .|.  .. .|| .| |.. | ||... |  . . .. 
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_eak_pd Subfamily eak 516-678 2.2e-10 34.4 In-house 39-204 (332) alignment 
Range on Protein: 516-678
Range on HMM: 39-204/332.0
ER-----TKTKAEKFASQNRTILPFDDNIVDIDgKTAENEDFYLNASFIYDDDPRQAvYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--
.|       .. |.       |.|.| . | .   .  |.. |.||| .   .  .  || .  .  ... |||| . .     .| |    | | ||  
qrllsisetarleavnrnvvkivpydrylvrlt.ssqlnrlGyinaslaefsevGrk.yiltGiasedkvfafwqmvleqkspaivqlledvelkleksd

NYWPDTGSEV--HGAFEIHLvSEHIWSDDYLVRSFYLKNlqNSQTRTITQFHYLSWQKESTPTSaKSILEFR
 |.|| . |.  .| ....   |..  . . .| . |.     .|  .  ...  | . ..|   .  | .|
kyfpdktreelkfGildver.kefvkrniletrllelsk..GnethrvlhykvfGwtettlpky.edflalr
subfamily_PTPN6_pd Subfamily PTPN6 517-757 3.1e-45 149.5 In-house 46-297 (306) alignment 
Range on Protein: 517-757
Range on HMM: 46-297/306.0
RTKTKAEKFASQN--RTILPFDDNIVDIDgKTAENEDFYLNASFIYDDDP-RQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYW
|....  . ...|  ..|||||.. | .  .    .. |.||..| .. .  .. |||.|   .. .. ||. .||    ..| . .  |  .||   ||
rkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYW

PDTGS-EVHGAFEIHLVSEhIWSDDYLVRSFYLK-NLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRS----SAVLVHSWDGSGRTGV
||. . | .|  ... |||    .|| .|.. .. . .....|.. |.|. ||  ...|.. . .|.| ..||. ..  .     ...||  .| |||| 
PdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGt

YCAVDVLCARLLR-GI-RQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
.  .|.|   . . |.  .||.  .|. .|.|| |.| | .|.|.||  ... .
fiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPRK_pd Subfamily PTPRK 517-753 2.5e-44 146.4 In-house 37-273 (314) alignment 
Range on Protein: 517-753
Range on HMM: 37-273/314.0
RTKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECK--QEKNYWPDT
 .| . ..  ..   ||..|   | .     ...  |.||..| |   | | .|..| |  . .. ||. ..... . .| |.   |    .  .|||. 
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GSEvHGAFEIHLVSEHIwSDDYLVRSFYLKNLQ--NSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVL
..  .| ....||. ..   ...|| | ...|.   ...|.. ||..|.| .  .|.||...|.. |.|.||   .   ..||   |.||||...|.|..
tev.ygdikvelvetel.laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

CArLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCV
.  ...  . .||  .|  ||...  || | .|.|..|  .
ld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 517-755 2.9e-39 130.0 In-house 41-282 (297) alignment 
Range on Protein: 517-755
Range on HMM: 41-282/297.0
RTKTKAEKF----ASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDdprQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEEC-KQEKNYW
...|.|||      |. . |||.| . | .     . .  |.||||.      .  .|. |.|  . .| ||. .... |  .| |.  .|  |. ..||
qpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgn...khrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryW

PDTGSEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPT--SAKSILEFRRKVNKSYRGRSS-AVLVHSWDGSGRTGVYCA
.|.|.   |   . | | .     .. |.. ... .. ..| . |.....| ... .   ||.|.|..   |.|.. ....  .|||   | |||||...
sdkgvttfGdvsvvllsvse.reGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

VDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
.|   |.  |   ..|.  .|..||..|  .| | .|.|.||  | .
idsvvaeakre.kevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 518-757 2.9e-51 169.4 In-house 41-280 (318) alignment 
Range on Protein: 518-757
Range on HMM: 41-280/318.0
TKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTG
. ... |.  .   ||..|.  | .. .. |..  |.||..| |   |.  |||||.| .  |  ||. .|. . ...| |.  ||  ..|  .|||. |
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg

SEVHGAFEIHLVSEhIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSY-RGRSSAVLVHSWDGSGRTGVYCAVDVLCA
|. .|.  ..| .| . ..||..|.| ... .....|.. |.|| ||  |..|.|. |.|.. |.|.|   .   ....||   | |||||..|||.|  
srsygklvvelkee.velsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille

RLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
|. .    .||  ||..||.||. || | ||....|  . . .
ri.kaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 518-756 1.2e-41 137.6 In-house 23-267 (274) alignment 
Range on Protein: 518-756
Range on HMM: 23-267/274.0
TKTKAEKFASQNRTILPFDDNIVDIDGKTAENE-DFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDT
..   ..   . .|||| .   | .  ...|.|   |.|| .|   | .. .|.|.| | .. .| ||. |.|. | ..| |   .| ...|  .|.||.
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

G----SEVHGAFEIHlVSEHIWSDDYLVRSFYLKNLQNsqTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGR---SSAVLVHSWDGSGRTGVYC
     || .| .||. |.. .  .|| ||...||.|..  .|... . | .|  . .| .|...|.. ..|..| . .    ..|.||   | ||||.. 
edyeiserygdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

AVDVLCaRLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQE
|... . | ||    .||. .| .|| .| ||| | .|..|..  ... 
aisiav.rqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 518-758 6.2e-41 135.2 In-house 41-284 (290) alignment 
Range on Protein: 518-758
Range on HMM: 41-284/290.0
TKTKAEKFASQNRTILPFDDNIVDIDGKTAENE--DFYLNASFIYDdDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPD
  |. .|     ..|.. ||| . .  .. ...  . |.||..| .    .  |||.|.| |. .. ||. |||. |. .| | .  | ...|   ||||
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpd

TGSEVHGAFEIHLVSEHIWSdDYLVRSFYLKNLQN-SQTRTITQFHYLSWQKES-TPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDV
....  | |.|.|..|.. . .|  | . .|| ..  .....||..  .|...   .  . ..| ... ... ..    ...||  |. ||..|.||...
sdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaat

LCARLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVN
   .  .   .|||.. ....| |. |.| | .|.....  | . ..
tinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 518-751 3.9e-31 103.0 In-house 3-235 (239) alignment 
Range on Protein: 518-751
Range on HMM: 3-235/239.0
TKTKAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTG
.| . .|   .   |. .| . | ..  . .    |.|||.. | |     |||.|   . .   ||. .||   |..| |.   | ...  ..||||. 
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SEvHGAFEIHLVSEHIWSdDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCaR
|. .  . . |    ... ||..|.| . .. ... | . |.|.  |  .  |  | ..| .|||. |     .   ..|   | |||| .  .| .  |
sk.ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.r

LLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYG
  .  . .|..  |. .|..|  || | .|. ... 
qakkqktvdifnyvkairedrphmvqtseqyvfihl
0036941 (Phosphotyrosine protein) phosphatases II 519-757 2.7e-57 189.7 In-house 35-277 (297) alignment 
Range on Protein: 519-757
Range on HMM: 35-277/297.0
KTKAEKFASQNRTILPFDDNIVDIdgktAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNYWPDT--
. .. .   . . |||.|.. | .     .... | |||.. |   ..  .||.|.| .. .. ||. .|...|  .|.|....|        |||..  
llpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

GSEVHGAFEIHLVSEHIW-SDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG--RSSAVLVHSWDGSGRTGVYCAVDV
.| ..| | ..|.|.... .||| .| . .....|...||.|.|||..|   ..|.|..|.|.| ..|.| ..   ... ||||. .| ||.|...|.|.
esltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadl

LCARLLR--GIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
.. .| .    ...|.. .| .||.|| |.| | .|.. .| .... .
mlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0046845 (Phosphotyrosine protein) phosphatases II 520-758 1.8e-56 186.9 In-house 25-275 (284) alignment 
Range on Protein: 520-758
Range on HMM: 25-275/284.0
TKAEKFASQNRTILPFDDNIVDIDGKTAE-NEDFYLNASFIYDDD----PRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNYWP
 .. .   . . |||.|.. | ..    . ... | |||..   |     ..  .||.|.| .. .. ||. .|...| ..| | ...| ..     |||
lpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwp

DTG-SEVHGAFEIHLVSEHIwSDDYLVRSFYLKNLQ-NSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYR--GRSSAVLVHSWDGSGRTGVYCA
..| . ..| | ..|.||..  ||| || ..|.||. ....||.|.|||.||   ..|.|....||| |.|.....  .... ..||...| ||||...|
legevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfia

VDVLCARLLRGIR--QIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVN
.|.|. .| .. .   .||  .| .||.|| ||| | .|...|| ...  ..
ldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 520-753 5.2e-35 115.7 In-house 30-262 (283) alignment 
Range on Protein: 520-753
Range on HMM: 30-262/283.0
TKAEKFASQNRTILPFDDNIVDIDGKTAenedFYLNASFIY--DDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTG
.. .|   .|. |.| | ..|... ..      |.||.||   ... ..  ||.||.|    .  ||. .... .. .| |.   | ...|   |||  |
adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

SEVHGAFEIHLVSEhIWSDDYLVRSFYLKNL-QNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCA
|| .| | . |  |   |. . .. . |..     .|  .. . .  | . .  .   |.. | . . .  . . . ..||   | |||.|..|. .   
sedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

RLLrGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCV
 .|     .|| |.|. .| || ..| | ||.|||.  |
dal.tesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 520-762 1.9e-17 58.2 In-house 28-264 (267) alignment 
Range on Protein: 520-762
Range on HMM: 28-264/267.0
TKAEKFASQNR--TILPFDDNIVDIDGKTAEnedfYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLsTPEECKQEKNYWPDTGSE
  ||| . .||    ||.||..| .  |. |    |.|||.. .   ..  .|. | | .  |. |.. | ...|  .| | |.    . . .||    .
siaeknqernrlddnlpyddtrvilrtkeee....yinasyv.egyktknafivtqdplkntitdfltvihdqkvpvivll.tkvftdnirlfwPPkmgq

VHGAFeiHLVSEH---IWSDDYLVRSFYLKnLQNSQTRTITQFHYLSWQKESTPTS-AKSILEFRRKvnKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLC
 .      |. ||      .|| . .. || ..|  .. .| ..|  |. ..      | ..    |  .     .  ..|.  || ||.| .  .|   
akkyq..dltvehslekeendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgilak..nqlengnrPlvvacsdGvGrsGtflvidsql

ARLlRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHLLK
 |. .     |.   . ..|.|| |.| | ...  ..  .|.  .  ||
era.ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
subfamily_PTPN3_pd Subfamily PTPN3 521-756 2.3e-42 139.8 In-house 37-274 (280) alignment 
Range on Protein: 521-756
Range on HMM: 37-274/280.0
KAEKFASQN--RTILPFDDNIVDIDGKTAeneDfYLNASFIYDDDPR-QAV--YIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPD
.  . .|.|  | |||.|.  | ..  ..   | |.||...  . |  ..|  |||.| | ..  . ||| .|.. . |.| | |  |  . |  .|||.
rkpenlsknryrdilpydatrvklkeset...d.yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

TGSEV-HGAFEIHLVSEhIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVL
|. |. .| |.... .|   .  |..| ..||. .... |.|.|. ||.|  .. |......||| ..|.|  .|... |.||   | |||||. .... 
tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilleta

CArLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQE
 | |.   ... ... | ..||||  .| | .|.|.|  .. . 
la.lieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 521-752 5.3e-31 102.6 In-house 5-235 (239) alignment 
Range on Protein: 521-752
Range on HMM: 5-235/239.0
KAEKFASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGSEv
. .|   .   |. .| . | ..  . .    |.|||.. | |     |||.|   . .   ||. .||   |..| |.   | ...  ..||||. |. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.

HGAFEIHLVSEHIWSdDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCaRLLR
.  . . |    ... ||..|.| . .. ... | . |.|.  |  .  |  | ..| .|||. |     .   ..|   | |||| .  .| .  |  .
ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.rqak

GIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGC
  . .|..  |. .|..|  || | .|. ... .
kqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 521-757 3.6e-29 96.4 In-house 41-236 (392) alignment 
Range on Protein: 521-757
Range on HMM: 41-236/392.0
KAEKFA--SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQaVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKqeknywpdtgsev
. |      . . |||.| . | ..     ... |||||.|   |  .  |||.|.| .. .  ||. ..|. |. .. ..  .|               
qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnek.ayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.............

hgafeihlvsehiwsddylvrsfylknlQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLlR
                            .  ..||..|||.  |  .  |  . |.|.| ..|.  .   .  ...|   | |||||  ..| . |.  .
............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvaha.k

GIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
  | .||.  |  .| .|  || | .|. ..||.| ...
ktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_ptpA1_pd Subfamily ptpA1 524-726 5.2e-16 53.4 In-house 46-266 (418) alignment 
Range on Protein: 524-726
Range on HMM: 46-266/418.0
KFASQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQavYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTP-EECKQE-KNYWPD------
. .|.||   ||| .   |..     ..   |.|| .|    |.|  .|..| |    || ||. .|.  . ..| ||   |.|. .   |||.      
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

-----TGSEVHGAFEIHLVsEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKV----N--KSYRGRSSAVLVHSWDGSGR
      | || |.. . || | |   .  . .  ..   . .|| |||..|  |     |  .. . .. . .    |       |   ..||   | ||
fsiygngnevfgtysvelv.eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGVYCAVDVLCARLLRGIRQIDVV
|| .|.  ..  .| . ..|.|  
tgtfctavimmkkldhyfkqldat
subfamily_Ptp69D_pd Subfamily Ptp69D 525-755 7.2e-44 145.1 In-house 50-284 (307) alignment 
Range on Protein: 525-755
Range on HMM: 50-284/307.0
FASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRqAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGSEVHGAF
.  .   | .||.. | .   . ...  |.|||||   . .   .|||| |  . |  ||. |..  | |.| ||  .| ...  . |||.     .|  
lknRyedikafDktRvkLkkingkedsdYinasfikgykek.kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdi

EIHLVSEHIwSDDYLVRSFYLKNLQNS-----QTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLL
 ..||||.   .||  |.... . ...     ..| ..|.||..|.    | .|...|.. ..|.. |.   | ..||   |.||.|.. |.|.|  .| 
lvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlk

RgIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
    ..|...|| .|| ||. .|   .|.. .|  ...
a.edkvdifetvkdLrsqRnllvqsleqYvflyralld
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 525-614 7.4e-08 26.3 In-house 98-181 (244) alignment 
Range on Protein: 525-614
Range on HMM: 98-181/244.0
FASQNRTILPFDDNIVDIDGKTAENedFYLNASFIYDdDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEEckqEKNYWPDT
. ... . |||| | | .   .  |   |.||||.     | | || .| | .     ||. . .  | ..| | . ||   | .||||.
wknregaglpfdfnrvplskgsmgn..tyinasfvgc.lgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee...edeywpds
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 526-757 8.2e-38 125.0 In-house 47-277 (315) alignment 
Range on Protein: 526-757
Range on HMM: 47-277/315.0
ASQNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRqAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNYWPD--TGSEVHGA
  . . |||.| . | ..    . .. |.|||.|   |     |||.|.|  . .  ||. ..|. |  .| ..  .|  .   ..||||  . |   |.
knryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGs

FEIHLVSEHIWSdDYLVRSFYLKNLQnsQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiR
....|.| .  . |  .| . ... .  ..||.|||..  | .. ..  . |.|.. ..|  . . .  ..|||   | ||||| ...|   |.. |. |
ikvellsleadt.dgvarklvtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrt.r

QIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
 .||  .|. ||..|  .| | ... ..|. | ...
svdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 526-754 2.4e-35 116.7 In-house 39-274 (287) alignment 
Range on Protein: 526-754
Range on HMM: 39-274/287.0
ASQNR--TILPFDDNIVDIDgKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNL-STPEECKQE-KNYWPDTGSEV-HG
...||   .||.||. | .  ...|    |.|| ..     ..  .||||.| .. .  ||. .... .. |. .    ||....  .|||.    .  |
vkknryadvlPiddtrvlls.aegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

AFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTS----AKSILEFRRKVNKSYRGR-SSAVLVHSWDGSGRTGVYCAVDVLCAR
 . . |..  | . .| ||.. | .|.  ..| . |...||| ... . .    .. .|. ..... .  .     ..||   | ||.|.. |. ||  |
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

LLrGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
|.  . ..|| |.| .|| .| ..| .  |..|.|  ..
le.dlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 526-681 4e-17 57.0 In-house 36-193 (297) alignment 
Range on Protein: 526-681
Range on HMM: 36-193/297.0
ASQNRTILPFDDNIVDIDGKTAENEdfYLNASFI-YDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGSEVHGAF
  . | || .||. | . .  .|..  |.|| .. . |.. .  || || | |. .  ||. .....|  .| ..  .|  ..|   |||..  |   | 
knryrdilatddtrvkllrviterd..yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

EIhlVSEHI--WSDDYL-VRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKV
..  | |..   ||..  |    |. .  |..| ..   .|||     |.  . .  |. .|
dv..vveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqv
0040439 (Phosphotyrosine protein) phosphatases II 527-755 3.8e-52 172.7 In-house 15-244 (249) alignment 
Range on Protein: 527-755
Range on HMM: 15-244/249.0
SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGSEVHGAFEI
 ... |||.| . | .      . . | |||.| |   ..  .||.|.| .. ...||. .|..|.  .|.|....|...||   |||. || ..| | .
nrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftv

HLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG--RSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQ
.|.|... .||| || ..|.||.....||.....|..|   ..| | ...|.| ..|.| ..   ... ||||. .| ||||...| . .. .| .  ..
tllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.lg

IDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
.|.  .|..||.|| |.| . .|.. .| ....
vdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 527-754 4.2e-51 169.1 In-house 13-240 (245) alignment 
Range on Protein: 527-754
Range on HMM: 13-240/245.0
SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGSEVHGAFEI
 ... |||.|.. | .     .. . | |||.. | . .   .||.| |... ...||. .|..|.  .|.|...|| ...|   |||. .| ..| | .
nrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftv

HLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYR-GRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQI
.|.||..  ||| || . ..||.....|.....|||.|   ..|.. ...|.| . |.| .. ...  ||||. .| ||||...|.. .. .| .  . .
tllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke.lgv

DVVATVEHLRDQRDGMVATGDQFKLVYGCVA
..  .|..||.|| |.| | .|.. .| ...
sleeavkelrsqRpgavqtpsqyrflyeall
subfamily_PTPRA_pd Subfamily PTPRA 527-754 7.2e-45 148.3 In-house 62-292 (330) alignment 
Range on Protein: 527-754
Range on HMM: 62-292/330.0
SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGSEVHGAFEI
..   |||.| . | .  |  ..|  |.||||| |   ..  .|||| | .  .  ||. ||..  . .| |.  .| |.||  .|||| |.  .|   .
nrvvnilPydfsrvilsvkeGveesdyinasfi.dGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirv

HLvSEHIWSDDYLVRSFYLKN----LQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLlRGI
..  ..  . || || | ...     .. ..| ..|||. || .   |. .. .|.. .||.|  .  .... ||   | |||| ....| . .|. .  
ev.edetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlerv.kae

RQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
|..||  .|..|| ||  || |  |....|  . 
rkvdvfefvkrlrlqrpqmvqtdeqyefiykvll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 527-756 2.2e-41 137.2 In-house 63-290 (319) alignment 
Range on Protein: 527-756
Range on HMM: 63-290/319.0
SQNR--TILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLStPEECKQeknYWPDTGSEVHGAFEI
 .||   ||.|| |.| ..    |.   |.||||.     |.  ||||| |    .| ||. ||.. .. .| |.  . | |   |||  . . .. |..
dknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrmiweyncstivllt.kdkcsq...ywplkivikeerfkv

HLVSEHiWSDDYLVRSFYLKN-LQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNK--SYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLlRGIR
.. | .  ...| ||.. | .  .. . | |||||.| | .   | ..  .. . .||..  |       ..||   |.|||||| ..|||  |. .  .
kvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm.keek

QIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQE
|.||  .|. ||.||. .|    |.|..|  . .|
qvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_CG7180_pd Subfamily CG7180 527-757 1.4e-37 124.0 In-house 46-290 (296) alignment 
Range on Protein: 527-757
Range on HMM: 46-290/296.0
SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ-EKNYWPDTGSEVHGAFEIH
 .. ...|.| | | ..    |... |.||... |   ... ||  ..|  . . .||. ......  ||.|. . . ..  ..||| .. | .| ....
nrdvkvvPyDynRvvLekldGeeksdYinavyv.dsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifve

LVSEHIWSDdYLVRSFYLKNL----------QNSQTRTITQFHYLSWQK-ESTPTSAKSILEFRRKVNkSYRGRS------SAVLVHSWDGSGRTGVYCA
.|.|. ...    | | |.             . .||....|..  |.  .. | |.....|.||.|. ..|..       . |.|.| ||..|.|||.|
iveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr.lwrekvdedpeegPvvvvssdGasRsGvyla

VDVlCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
.|. .  |..   ..||   |  || .| ..| . ...| .|  . . |
ida.nlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 527-753 1.9e-37 123.9 In-house 53-275 (315) alignment 
Range on Protein: 527-753
Range on HMM: 53-275/315.0
SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTgSEVHGAFEI
 .   |...|   | .     ...  |.||.|| |   ..  |||||.|  . .  ||. .... .  .| |.   | ...|  .||||    ..| . .
nryiniiaydksrvqlpllendphsdyvnanfi.dGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitv

HLVSEHIwSDDYLVRSFylKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLlRGIRQID
 ..|| .  ..| ||..      ... |.. |.|| || .   | .. ..... |.|..      .|..||  .| |||| ....| .  ..    . ||
trkseev.nteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa.eaenaid

VVATVEHLRDQRDGMVATGDQFKLVYGCV
|   .. .|..| .||.. .|....|  .
vynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 527-758 2.3e-30 100.4 In-house 52-280 (439) alignment 
Range on Protein: 527-758
Range on HMM: 52-280/439.0
SQNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQeknYWPDTGSEVHGAFEIHl
 . . . .||   | ..         |.|| .| .    . .|||.|.|   .   ||. .... .  .|.|.   |  .   |||  .  ..|   .. 
nrykdvgafdhtrvtlqeipgvphshyinanyi.kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...ywpsdaevcygdiavr.

VSEHIWSDDYLVRSFYLKNLQN--SQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAVDVLCARlLRGIRQI
|   |   .| .| | . | ..   . ||. ||||..| ..  |. |  .|.| | .| .        |.||   | ||||   |.|.   . |.   ..
vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq.lklenkv

DVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVN
|.   |. ||.||  || .  |. ..| .| ... 
dikgivkvlrkqrkqmvqalcqyvfiynavlediv
Y_phosphatase Protein-tyrosine phosphatase 528-754 6.6e-56 184.7 Pfam-A 6-234 (235) alignment 
Range on Protein: 528-754
Range on HMM: 6-234/235.0
QNRTILPFDDNIVDIDGKTAENEdfYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEEC--KQEKNYWP--DTGSEVHGAFE
....|||.|.. | ..|.. ...  | ||...   . ..  .||.| | .| |. ||. .||. | ..| | . ||   .. ..|||  . .|. .| ..
Rykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IHLV-SEHIWSDDYLVRSFYLKNLQNSQ-TRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIR
..|. .|. ....| .| . ||. .... .|...|.|| .|.....|.|.||.|.. |||.|| . .|. |.||. .|.||||...|.|.|. .| ..  
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

qIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
 .||. .|..|| || ||| . .|.. .| ...
.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 528-754 6.6e-56 184.7 In-house 6-234 (235) alignment 
Range on Protein: 528-754
Range on HMM: 6-234/235.0
QNRTILPFDDNIVDIDGKTAENEdfYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEEC--KQEKNYWP--DTGSEVHGAFE
....|||.|.. | ..|.. ...  | ||...   . ..  .||.| | .| |. ||. .||. | ..| | . ||   .. ..|||  . .|. .| ..
Rykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IHLV-SEHIWSDDYLVRSFYLKNLQNSQ-TRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIR
..|. .|. ....| .| . ||. .... .|...|.|| .|.....|.|.||.|.. |||.|| . .|. |.||. .|.||||...|.|.|. .| ..  
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

qIDVVATVEHLRDQRDGMVATGDQFKLVYGCVA
 .||. .|..|| || ||| . .|.. .| ...
.vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 528-760 1.1e-31 104.9 In-house 25-267 (270) alignment 
Range on Protein: 528-760
Range on HMM: 25-267/270.0
QNRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGSE--VHGAFE
  . |||     | ..  . ...  |.|| ..   | ... ||||..|  . . .||..||.. |  .| ..  ||  ..  . |||    |     . .
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgk

IHLVSEH-IWSDDYLVRSFYLKnlQNSQTRTITQFHYLSWQKESTPTSAK------SILEFRRKVNKSYRGRSS--AVLVHSWDGSGRTGVYCAVDVlCA
|. ....   .. |...   |.  .....| .. |.| .|  .. |...       ..|.  |.| .| .  .    .|||  .| ||||.  |.|  . 
ikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi.av

RLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEVNHL
|||   ...||.| .|.|| .|  .| . .|....|  |.. ....
rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN9_pd Subfamily PTPN9 528-753 8.7e-31 102.0 In-house 47-286 (297) alignment 
Range on Protein: 528-753
Range on HMM: 47-286/297.0
QNRTILPFDDNIVDIDGKTAENEDFYLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDT--GSEVHGAFE
.   .| .|.  | .  .  ...  |.||.|. |   ..  .||.| |    .  ||. .|.. |  .|     .| .. |  .|||..   |. .| ..
rytdvlcydetrvvlakvdedeasdyinanfv.dGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdls

IHLVSEHIwSDDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKS-----------YRGR--SSAVLVHSWDGSGRTGVYCAVD
.. |. .  ..|| ||.. .|| .....|..| | .|||    .| ||.|.|....|| .             .|.     ..||   | |||| ....|
vsnvevee.eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitld

VLCARlLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCV
.  .| |. . ..||| ||..|| ||  .. | .|... | .|
iclsr.leevgtvdvvetvkllrtqrafsiqtpeqyefcylav
0045098 (Phosphotyrosine protein) phosphatases II 529-759 1.9e-52 173.7 In-house 39-274 (278) alignment 
Range on Protein: 529-759
Range on HMM: 39-274/278.0
NRTILPFDDNIVDidgktaeneDfYLNASFIYDDdprQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGSEVHGAFEIHL
 . |||.| . |          | |.|||.|      .  .||.| |  | .|.||...|..|.  .|.| . .| ..||   |||. ||...| |...|
ykdilpydhsrVk.........d.YINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtl

VSEHIWsDDYLVRSFYLKNL----QNSQTRTITQFHYLSWQKESTPTSA--KSILEFRRKVNKSYR-------------GRSSAVLVHSWDGSGRTGVYC
.||... ||| .| ... ||    .. ..|..|..|||.|   ..|..   ||.||. . ... ..             ...  ||||   | ||||...
lseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlv

AVDVLCARLlrGiRQIDVVATVEHLRDQRDG-MVATGDQFKLVYGCVAQEVNH
|.. .. .|  . ...|.  .|..|| || | .| . .|.. .| .... ...
aaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0037934 (Phosphotyrosine protein) phosphatases II 529-754 1.2e-47 157.9 In-house 16-239 (243) alignment 
Range on Protein: 529-754
Range on HMM: 16-239/243.0
NRTILPFDDNIVDIdgktaENeDFYLNASFIYDDdPRqavYIAAQTPASSQIAA----FWQTIWQHGVCLVVNLSTPEECKQE--KNYWPdtGSEVHGAF
 ..|||.|.. | .     |. . |.||..||   ||   .|| | | .. ..     ||. .|..|.  .|.| ...| ..|    |||  |....| |
ysdilpydhsrvkl.....eg.sdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gevtygdf

EIHLVSEHIWsDDYLVRSFYLKNLQ-NSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKS--------YRGRSSAVLVHSWDGSGRTGVYCAVDVLC
...|.||.   ||| || ..|.||. . .||.....|||.|   ..|.| ...|.| ..|..         .. ... ||||   | ||||...| ....
tvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

ARLlrgirQIDVVATVEHLRDQRDG-MVATGDQFKLVYGCVA
 .|     ..|.  .|..||.|| | .| | .|.. .| ...
lll.....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 529-756 9.4e-44 144.5 In-house 15-241 (250) alignment 
Range on Protein: 529-756
Range on HMM: 15-241/250.0
NRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRqAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE-KNYWPDTGSEVHGAFEIHLV
   |...|   | .  . ...|  |.||||.   | |   .||.|.| .. |  ||. .... .  .| |.. .| ... ..|||  ..| .|   ..| 
yadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdvtvsll

SEHIWSdDYLVRSFYLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAVDVLCARLLRgIRQIDVV
|..... || .| . | . .... |.. |.|...|   . |  |...||...||..| .   .. |.|.   | ||.| ..|.| .  || .  ...|| 
skeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkk.ekvvdvf

ATVEHLRDQRDGMVATGDQFKLVYGCVAQE
  .. || .| ..| . .|.  ||  . . 
kvikvlrkdrphavesleqyvfvyeiilka
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 529-756 5.7e-41 135.9 In-house 31-254 (284) alignment 
Range on Protein: 529-756
Range on HMM: 31-254/284.0
NRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLStPEECKQeknYWPDTGSEVHGAFEIHLVS
   ||.|| |.| ..    |.   |.|||||     |.  |||.| |    .| ||. ||.. .. .| |.  . | |   |||  . . .. |.... |
ighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt.kdkcsq...ywplkivikeerfkvkvds

EHiWSDDYLVRSFYLKN-LQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNK--SYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLlRGIRQIDV
 .  |..| ||.. | .  .. . |.|.|||.| | .   | ..  .. . .||..  |     . ..||   |.|||||| ..|||  |. .  .|.||
ve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm.keekqvdv

VATVEHLRDQRDGMVATGDQFKLVYGCVAQE
  .|. ||.||. .|    |.|..|  . .|
ynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 529-755 4.2e-39 129.6 In-house 54-286 (325) alignment 
Range on Protein: 529-755
Range on HMM: 54-286/325.0
NRTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTI--WQHGVCLVVNLSTpEECKQEKNYWPDT--GSEVHGAFEI
 . ....| . | .  |  . .  |.|||.. ||  .. |..|||.| .. |  .|. .  |.  | .|.|    .. ..   |||.    |   |..|.
fknvvaldksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWrcsvvvvlneld.lgkdrcavywpkemgksktfGglev

HLVSEHIWsDDYLVRSFYLKNLQNSQTRTITQFHYLSWQ---KESTPTSAKSILEFRRKVNKSYRG---RSSAVLVHSWDGSGRTGVYCAVDVLCARLLR
.|..      ||. | . .|. .. .||.. ||.. ||.    .  |..  |||.   .|..  .     |. .|||  .| |||||. ..  . |... 
klrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvie

GIRqIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQ
  | .|.   |..|| .|  || | ||. |.| ....
esr.vdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 530-757 4.7e-39 128.8 In-house 50-276 (515) alignment 
Range on Protein: 530-757
Range on HMM: 50-276/515.0
RTILPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAvYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPD--TGSEVHGAFEIH
. |||.| . | ..    . .  |.|||.|   |  .| |||.|.|  . .  ||. ..|. |  .. ..  .|  .    .||||  . |   | ....
knilPydsvrvklevindnPhsdyfnasyipsfdndka.yiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikve

LVSEHIWSDdYLVRSfyLKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDV
||| .  ..  . |   |. |.....||.||||.  | .. .|  ..|.| . ..|  .    . ....|   | |||||....|   |.   . | .||
lvsleactg.gikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahaktt.rmvdv

VATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
  .|. .|..|  .| | .|. ..|| | ...
fnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 530-751 3.9e-31 103.1 In-house 10-233 (237) alignment 
Range on Protein: 530-751
Range on HMM: 10-233/237.0
RTILPFDDNIVDIDGKTAEnEDfYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGS-EVHGAFEIHL
  |  .| . | . |  ..  | |.||... . |     ||||| |  |    ||| .||    ..| |.   | ...|  .|||.|   . .| . . |
gnivaydhsrvvlkgagsg.sd.yinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvsl

VSEHIWSdDYLVRSFYL-KNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKV-NKSYR-GRSSAVLVHSWDGSGRTGVYCAVDVLCaRLLRGIRQI
  .  .| || |||. | |.|.  . | | |... || .   |  . ..| ||... |.|    .|.  ..|   | ||||..  .| .  |  .  . .
kkkeefs.dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.rqakekkvv

DVVATVEHLRDQRDGMVATGDQFKLVYG
|.   |  . ..|  .. | ||. ... 
diynyvysieedrpyiiqtkdqyvfihq
0049772 (Phosphotyrosine protein) phosphatases II 530-758 2.1e-19 65.8 In-house 53-281 (314) alignment 
Range on Protein: 530-758
Range on HMM: 53-281/314.0
RTILPFDdNIVDIDGKTAENEDfYLNASFIYDDdprqAVYIAAQTPASSQIAAF----------WQTI--WQHGVCLVVN--------------------
  |||.| | | ..|   .. | | |||..         .||.|.| .  .  |          |. .  ... |  .|                     
ldilpad.nrvilpglpvsgsd.yinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKt

-LSTPEECKqekNYWPDTGSEVHGafeihlvsEHIWSDDYLvrsfylknlqnsqTRTITQFHYLSWQKESTPtSAKSILEFRRKVNKSyrGRSSAVLVHS
 | .. .     |...    | .         | .......             .|.. ..... .  .|.| . . ..|| . ...    . ..|||| 
pllildgng...neptaadlellk........eelydpelf.............erlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHC

WDGSGRTGVYCAVDVLCARLlrgirQIDVVATVEHLRDQRD-----GMVATGDQFKLVYGCVAQEVN
..| ||||...... |. .|     ....  ..|..| .|      |.. . .|.  .. .. . ..
kaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 530-616 7.5e-08 26.5 In-house 63-155 (350) alignment 
Range on Protein: 530-616
Range on HMM: 63-155/350.0
RTILPFDDNIVDIDGKTAENEDfYLNASFIYDDDPR----QA-VYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGS
| .|.   .  |   .. . .| |.||...    .         |||.|.|  | .  |.. | . .| ... |..  |   ||  .||.. . 
rvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsy
0041856 (Phosphotyrosine protein) phosphatases II 531-756 2.7e-30 100.7 In-house 9-170 (182) alignment 
Range on Protein: 531-756
Range on HMM: 9-170/182.0
TILPFDDNIvdidgktaenEDFYLNASFIYDDDPRQAvYIAAQTPASSQIAAFWQTIWQHGVCLVVNLStpeeckqEKNYWPdtgsevhgafeihlvseh
 |||.| ..             | ||...  . | .  .||.|.|  |..|.|.......|. ..|||.       | .|||                  
dilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.......eelywp..................

iwsddylvrsfylknlqNSQTRTITQFHYLSWQKESTPTsAKSILEFRRKVNKsyrgRSSAVLVHSWDGSGRTGVYCAVDVLCARllrgirQIDVVATVE
                 .  .|...|..||.|   ..|.   ..|.| ..|..    .. .||||   | ||||...| .... .      ....  .|.
.................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavk

HLRDQRDGMVATGDQFKLVYGCVAQE
..| .| ||| | .|. ... .. ..
lvrsrRpgmvitpnqyfflqlallel
subfamily_CG42327_pd Subfamily CG42327 533-684 8.7e-19 62.3 In-house 38-193 (319) alignment 
Range on Protein: 533-684
Range on HMM: 38-193/319.0
LPFDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECK--QEKNYWPDT----GSEVHGAFEIHL
.|. .  |  . .. ...|.||.||..   |  .. |||||..  .  ..||.|.|.     .| |. . |    .  .|.|      . ...| . . |
vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtl

VSEHiWSDDYLVRSFYLKNLQNSQTRTITQFHYlSWQKESTPTSAKSILEFRRKVNKS
       | |.. .. ||.......| .| . |  | .   |.. ....    .|..|
kgre.vkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0044763 (Phosphotyrosine protein) phosphatases II 534-750 6.9e-24 79.9 In-house 1-164 (178) alignment 
Range on Protein: 534-750
Range on HMM: 1-164/178.0
PFDDNIVDIDGKTAENEDFYLNASFIYDDdprqaVYIAAQTPassqiAAFWQTIWQHGVCLVVNLSTPEE---CKQEKNYWPDTGsevhgafeihlvseh
|.|...|...    ..  .|.|||.|...     .|.... |     |.... ....|. ..|||... |   .|  . .. ..|               
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

iwsddylvrsfylknlqnsqtrtiTQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARllrgirQIDVVATVE
                         |.... .   ..|.. . .||| . ... .  . ..||||   | ||.|. .| . .. .      .... . .|
........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaie

HLRDQRDgMVATGDQFKLVY
..| .|  .| . .| . .|
lvrerRp.ivpnpgqlrqLy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 535-754 7.4e-14 45.8 In-house 63-282 (302) alignment 
Range on Protein: 535-754
Range on HMM: 63-282/302.0
FDDNIVdidgKTAENEDFYLNASFIYDDDPRQAVYIAaQTPASSQ---IAAFWQTIWQHGVCLVVNLSTPEECKQ-EKNYWPDTGSEVHGAFEIHLVSEH
 |.|.|    |.....|.|.||| .   . .. ...| | | ...   .. ||. ..|. .  || |  .||.|.  ....| .  . . . .. .    
ldsnlv....kleaepdsyvnaskvevPeltrsiila.QlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrk

IWSDDYLVRSFYL----KNLQNSQTRTITQFHYlsWQKESTPTSAKSILEFRRKV-NKSYRGRSSAVlVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDV
. . .  .  ...    ..  ||   ... ...  |.... |..  .. .   || .|.  . ...| . |  |.|| |.  .. |   .| .|  .  .
VekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakkikadentv.ivSknGaGRagafltlavaveklqkg.kepni

VATVEHLRDQRDGMVATGDQFKLVYGCVA
  .|. .| ||  .| . .|.  .| ...
keivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 535-757 7.3e-09 29.6 In-house 53-279 (303) alignment 
Range on Protein: 535-757
Range on HMM: 53-279/303.0
FDDNIVDIDGKTAENEDFYLNASFIYDDDPRQAvyIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK-N-YWPDtgSEVHGAFEIHLVSEHIW
| | |.    |    .  |. ||..  |  ..|  | .| | |   | ||| | .  |  |. | |  | ..   .  .|    .    ||   .    .
fvdvicldhskvklsdssyihasyleldsskka..iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr..nqdflkfeersirvgef

SDDYLVRSFYLKNLQNSQ--TRT-ITQFHYLSWQKESTPTS-----AKSILEFRRKVNKsYRGRSSaVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQID
    |.  . || |  |.   .. .   || .| ..| |.       | | . .  . | |   .   .  |  | ||.| ..  .     |      .|
krvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrk.ysdstp.tvymslsgcgragtfalfetahlslhseqasld

VVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
.|  .| .|. |   |    || .||  .|. |
lvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 536-749 1.9e-09 31.6 In-house 68-281 (305) alignment 
Range on Protein: 536-749
Range on HMM: 68-281/305.0
DDNIVDIDGKTAENedfYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGSE---VHGAFEIHLVSEH
| ..| .|  .  .   |. | ..      .  .|.|| |    |  ||  . |. |  .| |    |  .    .||| .  |   ...   .  ||  
dqsavkldkpspsd...yihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs

IWSD-DYLVRSFYLK-NLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVnksyRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVAT
   . |  ..   |. .   .|. .. ....  |     |    . ||.   .    ||    ..||   | ||||   |.. .  ..    .   .   
kpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai....rgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpel

VEHLRDQRDGMVATGDQFKLV
|  |||||   . .  |.  .
vkalrdqrafsiqndvqylfi
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 547-757 1.8e-15 51.8 In-house 63-271 (288) alignment 
Range on Protein: 547-757
Range on HMM: 63-271/288.0
AENEDFYLNASFIYdDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEE-CKQ-EKNYWPD-TGSEVHGAFEIHLVSEHIWSDDYLVRSFYL
 .. ||| .|  .    . .   | ||.|  . |  .|. . . .|  .| |.   |  |.  ..|.|   | ...       | ..    | ||.   |
sddpdfyiaanvvs.sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsll

KNLQNSQTRT-ITQFHYLSWQKESTPTSAKSILEFRRKVnksyRGRSSAVLVHSWDGSGRTGVYcAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVAT
.. .. ...  . . |.| |.... | . .| | .   .    .     ..|||  |.||||   .. .. .. ||   .. .   ...||..|   . |
riskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtl.ililialeslrlddflgirsllaklreerfkaiqt

GDQFKLVYGCVAQEV
  |.  |. || .|.
emqylyvhrcvleel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 548-751 1.7e-14 48.1 In-house 63-263 (281) alignment 
Range on Protein: 548-751
Range on HMM: 63-263/281.0
ENEDFYLNASFIYDDDpRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTgseVHGAFEIHLVSEHiWSDDYLVRSFY---
.|   |. | .|      .  || .| |     | ||. |||     .| |    | ..||  .|.|      | ....  .|   . |  . .|.    
knstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn...ahcclqfdklsvs.yedstvnkslvttr

LKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVnksyRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRD-QRDGMVA
|.   . .|| ||.. .  |     | |.. .|.  ||.    | ||.  ..|   | ||.|   ||..    .   .   |.   | |||   |   | 
lnlsyegetrlithwlwkewpdwqvpessevmlkilrki....rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvq

TGDQFKLVYG
| .|. |.. 
tlqqymliwk
0043147 (Phosphotyrosine protein) phosphatases II 549-750 2.6e-26 87.8 In-house 3-154 (172) alignment 
Range on Protein: 549-750
Range on HMM: 3-154/172.0
NEDFYLNASFIYDDDPRQAvYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPeeckqeknywpdtgsevhgafeihlvsehiwsddylvrsfylKNLQN
. . | |||...     .  .|| | | .. .| ||. ....|. ..||| .                                            ..  
egsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel..........................................lydpe

SQTRTITQFHYLSWQKESTPtSAKSILEFRRKVNK-SYRGRSSAVLVHSWDGSGRTGVYCAVDVLCarllrgiRQIDVVATVEHLRDQRDGMVATGDQFK
  .|.. |..||.|   ..| ... .||| . ...   . .. .||||   | ||||. .| . ..       .....  .|...|..| |.| . .| .
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqyr

LVY
..|
fly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 550-751 6.1e-13 43.4 In-house 58-264 (285) alignment 
Range on Protein: 550-751
Range on HMM: 58-264/285.0
EDFYLNASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEKN--YWPDTGSEV--HGAFEIHLVS--EHIWsDDYLVRSFYL
.  |. ||..      |. ||..| |    .. ||. |.|  .. |. | |  |   ||   |.|.   ||   | .|| |    |       .. .. .
drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeai.agtilnaltv

KNLQNSQTRTITQFH--YLSWQKESTPTSAKSILEFRRKVNKSyRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVA
 | ... .  .   |     |  . .|  |. ..|. . |.|    .   . ||   | |||  .  .|    |..    .|...  |  .|  |   | 
intedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrtatfvgidyatirimen.pniemldivremramrfqavq

TGDQFKLVYG
.  || ..| 
shmqflflyv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 552-614 8.2e-06 19.4 In-house 91-156 (349) alignment 
Range on Protein: 552-614
Range on HMM: 91-156/349.0
FYLNASFIYDDD-PRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDT
 |.|| ..       .  ||| | |  | .  |.. |   || ||. |.  .|   ||   || . 
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
0051082 (Phosphotyrosine protein) phosphatases II 553-751 5e-25 83.3 In-house 5-147 (151) alignment 
Range on Protein: 553-751
Range on HMM: 5-147/151.0
YLNASFIYDDdprqavYIAAQTPassqIAAFWQTIWQHGVCLVVNLSTPEECKQEKNYWPDTGsevhgafeihlvsehiwsddylvrsfylknlqnsqtR
|.|.|.. .       ... . |     |.|.......|.  .||| ..|| . ...|.|..|                                    .
yinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeergycpeylpelg....................................i

TITQFHYLSWQKESTPTSAKSILEFRRKVNKsyrGRSSAVLVHSWDGSGRTGVYCAVDVLCARllrgirqIDVVATVEHLRDQRDGMVATGDQFKLVYG
.......|.|.  ..|.| ...||| .....    ..  |||| . | ||||. .|.. .. .       ... ...|..| .| |.| . .|| ... 
evlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_egg_pd Subfamily egg 553-755 2.4e-14 47.7 In-house 70-268 (307) alignment 
Range on Protein: 553-755
Range on HMM: 70-268/307.0
YLNASFIyDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEKNYWPDTGSE----VHGAFEIHLVSEHIwSDDYLVRSFYLKNLQN
.. |  . . .|    .| ||.|       ||. ..|  |  .| |..  | .. . ||| . |.    | |...|. .  .    | | |   || .  
fihanrv.kGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvds.kadplfrvtklklvGg

SqtrtITQFHYLSWQKESTPTSAksiLEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRG-IRQIDVVATVEHLRDQRDGMVATGDQFK
       . .   || .   .|    . .  .| .  |  |  |.|.. .|  ....  |...    |||| | .  |  .|  || .|   | .  .. 
d....deerflehwqgdvnnssd...vysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllyl

LVYGCVAQ
.||  |. 
fvyrlvlf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 553-748 6.4e-13 43.5 In-house 48-250 (290) alignment 
Range on Protein: 553-748
Range on HMM: 48-250/290.0
YLNASFIYDDDprQAVYIAAQT-------PASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE------KNYWPDTGS-EVH-GAFEIHLvSEHIWSDDYL
|. |...   .      |. |.          | |  || .. |  |  || |   || ...      ..| |..   |.  . ....   . .  ||  
yiHAnrvtcpn..glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.kskekeddve

VRSFYLKnLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSyrgrSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRD
.|   .|  .. .  |.|   . .|.| ... . |..|.  .||..|     ..|.||  ||  |  .  |... .  .     .. ... .. || ||.
tRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas....ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

GMVATGDQFKL
 .. .  ..  
laitsalelaf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 553-747 1.7e-12 42.0 In-house 69-267 (307) alignment 
Range on Protein: 553-747
Range on HMM: 69-267/307.0
YLNASFIYDDdPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGS--EVHGA----FE-IHLVSEHIWSDDYLVRSFYL
|. | ..     .   .|.|| |  . .  ||  . |. |  |. |    |  .   ..|||       |.|          | ....  |. |.    |
yihanylgia.ikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttl

KNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVnksyRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATG
|    ...|||... .  |  . .|    . ...   |    |.    |.||   | ||.|   |. ..  ....||   |.   || ||.||.  . | 
kvdwaqksrtiqhlqwenwpdrgvpqinltainlleav....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqte

DQFK
 |. 
aqyl
0051429 (Phosphotyrosine protein) phosphatases II 554-759 2.7e-27 91.5 In-house 7-227 (272) alignment 
Range on Protein: 554-759
Range on HMM: 7-227/272.0
LNASFIYDDdPR---QAVYIAAQTPASSQIAAFWQTiWQHGVCLVVNLSTPEECKQEK--NYWP------------DTGSEVHGAFEIHLVSEHIWSDdY
 ||...     |     ...... |.   .| ||.  ...|.  .|.| ..||....|   |||            .. .  .||. . |.||....| |
iNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld.y

LVRSFYLKNL-QNSQTRTITQFHYLSWQKESTPTSAksILEFRRKVNKsyrgrSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQID--------VVA
..| ..|..| .....|.....||..|   ..|..|  .||. . ...     . .|||| . | .|||...|.. | ... .    .|        . .
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsle.tivddYlltnlylee

TVEHLRDQRDGMVATGDQFKLVYGCVAQEVNH
.||.||.|| |.| | .|.. .| .... .. 
aveelraqrpgavqteeqylflyeallellrs
0046846 (Phosphotyrosine protein) phosphatases II 555-753 1.4e-25 85.5 In-house 11-169 (176) alignment 
Range on Protein: 555-753
Range on HMM: 11-169/176.0
NASFIYDDDPRQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGSEVHgafeihlvsehiwsddylvrsfylknlqnsqtr
. ..|...    . .|| | |  ...|.|.. ....|. .|||| .. | ..    ||||.  .. .                                 
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.................................

titQFHYLSWQKESTPTSaKSILEFRRKVNKSYRGRsSAVLVHSWDGSGRTGVYCAVDVLCARllrgiRQIDVVATVEHLRDQRD-GMVATGDQFKLVYG
   |...| |   ..|.. . .||. . ... ..     |||| . | ||||...| . |. .     ....|  .....|.||  |.| | .| . .| 
...qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQyrflye

CV
..
fe
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 565-746 6.1e-16 52.9 In-house 92-272 (290) alignment 
Range on Protein: 565-746
Range on HMM: 92-272/290.0
RQAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTP-EECKQ-EKNYWPDTGSEV--HGAFEIHLVSEHIWSDDYLVRSFYLKNLQNSQTRTITQFHYL
 .|..| .| .  . .  .|. . |..|  .| |    |. |   ..|.|..  ||   |.. .    |.   ..   . . ... .. .   .  ..  
lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkik

SWQKESTPTSAKSILEFRRKVnksyRGRSSAVLVHSWDGSGRTGVYCAVDVlCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQF
||   | . |. ..|   | .    |  |  | ||   | |||| . |..| ....|   ...|.. .|  ||. | . |    |.
swpdksvalstlallrtlril....rkasGpvvvhcsaGiGrtGtfvaiev.glqilldGkeldlldlvralrnsrlnsvqvdiqy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 566-750 6.6e-19 62.9 In-house 4-197 (199) alignment 
Range on Protein: 566-750
Range on HMM: 4-197/199.0
QAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNYWPDTGSEVHGAFEIHLVSEHIW-SDDYLVRSFYLKNLQ--NSQTRTITQFHYL
|  |||.| |    .| ||| .|. |   .| .   .  |.     ||| | | .     . .... |    || . .. | |       || |... . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWQKESTPTSAKS--ILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAVDVLCARL-LRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVY
||.. .||  |    ..   |.| | |   . . |.||  || | |||. |.|.            .|.      ||. | |.... ......|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 566-750 7e-19 62.8 In-house 3-196 (198) alignment 
Range on Protein: 566-750
Range on HMM: 3-196/198.0
QAVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNYWPDTGSEVHGAFEIHLVSEHIW-SDDYLVRSFYLKNLQ--NSQTRTITQFHYL
|  |||.| |    .| ||| .|. |   .| .   .  |.     ||| | | .     . .... |    || . .. | |       || |... . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWQKESTPTSAKS--ILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAVDVLCARL-LRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVY
||.. .||  |    ..   |.| | |   . . |.||  || | |||. |.|.            .|.      ||. | |.... ......|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
0049260 (Phosphotyrosine protein) phosphatases II 567-750 3.2e-24 80.7 In-house 9-143 (152) alignment 
Range on Protein: 567-750
Range on HMM: 9-143/152.0
AVYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQ--EKNYWpdtgsevhgafeihlvsehiwsddylvrsfylknlqnsqtrtitQFHYLSWQK
  .||.| | .  .| ||. ....|.  .|.| ...| .   ...|.                                            |...| |  
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpD

ESTPTSAKSILEFRRKVNKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCarllrgiRQIDVVATVEHLRDQRDGMVATGDQFKLVY
 ..|...  .|.. . ..| .. ..  ||||   | ||||...| . ..       .....  .|...| .| |.| . .| ...|
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
0036282 (Phosphotyrosine protein) phosphatases II 568-750 4.9e-25 83.6 In-house 18-163 (174) alignment 
Range on Protein: 568-750
Range on HMM: 18-163/174.0
VYIAAQTPASsqiaaFWQTIWQHGVCLVVNLSTPEECK--QEKNYWPDtgsevhgafeihlvsehiwsddylvrsfylknLQNSQTRTITQFHYLSWQKE
 .|| | |..     ||. ....|.  ||.| ...| .     ||||.                                |... .|.. |..|| |   
rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lredlerlgiqylylpwpDh

STPTSAKsILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVYCAVDVLCARLLrgIRQIDVVATVEHLRDQRDGMVATGDQFKLVY
..|.... .||| . |.. .   ..  ||||   | ||||. .| . .. .||   . .|....|  || || ||| | .|.. .|
gvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 568-746 8.3e-15 49.3 In-house 91-270 (301) alignment 
Range on Protein: 568-746
Range on HMM: 91-270/301.0
VYIAAQTPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTG-SEVH-GAFEIHLVS-EHIWSDDYLVRSFYLKNL-QNSQTRTITQFHYLS
 .||.|.| ..    ||  . |. |  .| |.   | ..|  ..| | .  .... | |.|.... |.| ...   |.. ...  .. .|||.| . | .
rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqyse

WQKESTPTSAKSILEFRRKVNKSYRgrssAVLVHSWDGSGRTGVYCAVDVLcARLLRGIRQIDVVATVEHLRDQRDGMVATGDQF
| .. .| |   . ..   | || .     ..||  .| ||.  . . ..| || .   ..|..  ...|||..|   | |  |.
wtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigteyl.areveadptieltealkhlrehrwngvqtnsql
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 574-756 4.6e-08 26.9 In-house 98-287 (302) alignment 
Range on Protein: 574-756
Range on HMM: 98-287/302.0
TPASSQIAAFWQTIWQHGVCLVVNLSTPEECKQEK--NYWPDTGS-EV-HGAFEIHLVSEHIWSDD------YLVRSFYLKNL--QNSQTRTITQFHYLS
.|  | .  .|  | |. |..||.|..  | ...|  .|. |    |.  | . .. || .   ..      . . .  .||   .. . .|.  ... .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WQKESTPTSAKSILEFRrKVNKSYRgrsSAVLVHSWDGSGRTGVYCAVDVlCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQE
| .  .|  |.. |.   |  .||.    .||||   | ||||   |.      |    .  |..  |  .|. | | | . .|   .  ||.. 
wpdhGapkeaytaldil.kfcesyk...knvlvhcsaGvGrtGtlvaiky.GiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 578-742 2.6e-12 41.4 In-house 39-206 (255) alignment 
Range on Protein: 578-742
Range on HMM: 39-206/255.0
SQIAAFWQTIWQHGVCLVVNLSTPEEC--KQEKNYWPDTGSEVHGAFEIHLVSEHiWSDDYLVRSFY-LKNLQ-NSQTRTITQFHYLSWQKESTPTSAKS
  ...|.||| | .   || |.  .|   .. ..|.|    |     .. ... .  | | ..|    . .|    .|.|.. ..|  | .. .|  |. 
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

ILEFRRKVNKSyrgRssAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQ-----IDVVATVEHLRDQRDGMVAT
||.  . | .|   .  .|.||   | ||.  .  ....  ...| ...     .| .  .|.|| .| . . |
ilnilkvvrds...k..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht
subfamily_hpo-7_pd Subfamily hpo-7 578-742 4.7e-11 37.1 In-house 45-212 (263) alignment 
Range on Protein: 578-742
Range on HMM: 45-212/263.0
SQIAAFWQTIWQHGVCLVVNLSTPEECKQE--KNYWPDTGSEVHGAFEIHLVSEHIWSdDYLVRSFYLKN-LQ-NSQTRTITQFHYLSWQKESTPTSAKS
 .|..|.||| | .   || |.  .|  .|  ..|.|    |     .. ... .. | | |...  | . |.   .|.|.... |  | ..  |. |..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelare

ILEFRRKVNKSyrgrsSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQ-----IDVVATVEHLRDQRDGMVAT
||.  . . .|       . ||   | ||.  .  ....  ...| ...     .| .  .|.|| .| . . |
ilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
0048076 (Phosphotyrosine protein) phosphatases II 584-752 7.9e-17 56.8 In-house 22-138 (145) alignment 
Range on Protein: 584-752
Range on HMM: 22-138/145.0
WQTIWQHGVCLVVNLstpeeckqeknywpdtgsevhgafeihlvsehiwsddylvrsfylKNLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNK
.......|. .|.||                                              . ..  .|...|..||.|   ..|.... .||| . ...
lellkdlgittvlnl.............................................tselellerlgiqylylpwpDhgvpdllellleflefiee

SYRGRsSAVLVHSWDGSGRTGVYCAVDVLCArllrgiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGC
 ..     |||| . | ||||...| ...        .....  ..|..| || |.| . .|.. .| .
alkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 584-750 5e-16 54.2 In-house 22-138 (144) alignment 
Range on Protein: 584-750
Range on HMM: 22-138/144.0
WQTIWQHGVCLVVNLSTPEECKQEKNYwpdtgsevhgafeihlvsehiwsddylvrsfylknlqnsqtrtITQFHYLSWQKESTPTSAKSILEFRRKVNK
.......|. .|.||... |   ....                                           ..|...|.|   ..|.... .||| . ...
lellkklgittvinlteeyepeflere...........................................giqylhlpwpDhgvpdllellleflefiee

SYRgRSSAVLVHSWDGSGRTGVYCAVDVLCarllrgIRQIDVVATVEHLRDQRDGMVATGDQFKLVY
 .. ..  |||| . | ||||...| ...        .....  .....| .| |.| . .|.. ..
ale.eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnpgqlrfLl
0038934 (Phosphotyrosine protein) phosphatases II 629-751 6.7e-07 24.6 In-house 38-171 (194) alignment 
Range on Protein: 629-751
Range on HMM: 38-171/194.0
EHIWSDDYLVRSFYLKNLQNSQTRTIT--------------QFHYLSWQK--ESTPTSAKSILEFRRKVNKSYRG-RSSAVLVHSWDGSGRTGVycavdv
.. .| . ||| . |.| ..    ..|               ..||...     |. | . .|.| . |.. ..   . .|.||   | ||||.      
lyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGt......

LCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYG
|.|. |   ..... . ....|. | |.. . |... .. 
lvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 633-755 4.9e-15 49.8 In-house 74-192 (440) alignment 
Range on Protein: 633-755
Range on HMM: 74-192/440.0
SDDYLVRSFylknLQNSQTRTITQFHYLSWQKESTPTSAKSILEFRRKVNKSYR-GRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRgIRQIDVVATVEH
..||.  |.    ..  ..||. |.|| .|  .. |  |  .|.. . ||.|     .. .|||.  |.|||||  ||| .     |   |||... .. 
dsdyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakr.sdqidifsfins

LRDQRDGMVATGDQFKLVYGCVAQ
.|..|  || | .|. .|. .| .
mrnnrpqmvqtpeqyafvheavle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 649-752 3.5e-10 34.1 In-house 183-282 (305) alignment 
Range on Protein: 649-752
Range on HMM: 183-282/305.0
SQTRTITQFHYLSWQKESTPTSAKSILEFRRKVnksyRGRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKL
...| .|..|.  |     |..  .|||.  |     |     . ||   | ||||    .. .. .|| |    |    . ..|.||.  . | .|. .
ekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf

VYGC
|.  
vhqv
PTPc_DSPc_SM00012 653-754 7.6e-27 88.9 In-house 1-104 (105) alignment 
Range on Protein: 653-754
Range on HMM: 1-104/105.0
TITQFHYLSWQKESTPTSAKSILEFRRKVNKSYRGRS--SAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVY
|....||..|.....|....||||. |.|.|... ..  . |.||. .| ||||...|.|.|. .| .. ...|.  .|..||.|| ||| | .|.  .|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

GCVA
 ...
rall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 682-754 3.7e-08 27.5 In-house 255-341 (350) alignment 
Range on Protein: 682-754
Range on HMM: 255-341/350.0
NKSYRGRSSAVLVHSWDGSGRTGVYCAVDVLCA------RLLRGIRQIDVV--------ATVEHLRDQRDGMVATGDQFKLVYGCVA
. .   |||..|||   | ||||.....| |         | .  |..||          .| .|| ||  || . |||  .| .. 
shldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 687-757 8.4e-10 33.0 In-house 226-295 (297) alignment 
Range on Protein: 687-757
Range on HMM: 226-295/297.0
GRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGiRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCVAQEV
 |.  .|||   | ||.||    ||. |.| .. |  || | ...||.||  .| | .||.|.|  | . .
prnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 687-753 8.3e-09 29.5 In-house 245-311 (319) alignment 
Range on Protein: 687-753
Range on HMM: 245-311/319.0
GRSSAVLVHSWDGSGRTGVYCAVDVLCARLLRGIRQIDVVATVEHLRDQRDGMVATGDQFKLVYGCV
 .   . ||  || ||||.  | |.   .|    | .|.  .| ..| .|   | | .|....|  .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl