Gene K08B12.3 in Caenorhabditis elegans

Synonym: CELE_C13C4.4, C13C4.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP119_AA protein Get Run
CeleP119_AA_4-252 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Chronophin_1 5-243 2.4e-36 116.5 In-house 2-249 (261) alignment 
Range on Protein: 5-243
Range on HMM: 2-249/261.0
SSVLIDLSGTIHIEEFAIPGAQTALELLRQH-AKVKFVTNTTKESKRLLHQRLINCGFK-VEKEEIFTSLTAARDLIVKNQY-RPFFIVDDRAME-D--F
..||.|| | .  .| |.|||. ..| |.|.  .| |||| ... .. | .|| . |.. |..||||.| .||. |. ...     ...  . .  .   
qlvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrkelre

EGIS-TD----DPNAVVIGLApEKFNDTTLTHAFRLIKEKkASLIAINKGRYHQTNAGLCLGPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSLneNV
.|.  .|    ...|||.|   |... . |..| .||..  | ..| |. ... .. |   | |. .| .|  .| |...||||. . ||.||..   ..
aGlrlvdepedrveaVvvGyd.eelsfeklaeaialirdg.alfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealeki..ga

DFSSAVMIGDDVNDDALGAIKIGMRAILVKTGKFRDGDELKV--KNVANSFV
| ...||.|| .. | | . . |....|| ||  .. .  ..  . . .  |
dpeetvmvGDRldTDilagaraglstllvltGvseleeaqaykkdlrPdavv
Hydrolase haloacid dehalogenase-like hydrolase 6-207 1.8e-10 32.8 Pfam-A 3-207 (215) alignment 
Range on Protein: 6-207
Range on HMM: 3-207/215.0
SVLIDLSGTIHIEEFAI--PGAQTALELLRQH----------AKVKFVTNTTKEsKRlLH--QRLINCGFKVEKEEIftSLtAARDLIVKNQYRPfFIVD
 |..|. ||.   | ..  .|.. ||.|....          | |.. .. . . .  |.  .  | .| .   ..|  .|   .... ... |. . .|
tvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstr.gg.ltgfatfigrgvsgkvdgi..vl.gnpewmtalglrv.iapd

DRAMEDFEGISTDDPNA-VVIGLAPEKFNDTTLTHAFRLIKEKKAS-L-IAINKGR------YHQTNAGLclgpgtyvAGLEYSAGVEativGKPNKLFF
..|.|. .   |.   |  .. |.  .|.|.   .|  .... |.  . ...  |          . ||.        ..    |.|     |||..  |
lvaaegqskgrtvvvvavqaralgviafadpvkpeaaeavasLkeaGievvlltgdnpetaeaiakqagi........edslvfaevv....gkPepklf

ESALQSLNENVDfsSAVMIGDDVND
. |.. |...     ..|.||.|||
vaaieeLqidpg..evamvGDgvnD
Chronophin_2 6-75 3.2e-08 24.2 In-house 2-73 (282) alignment 
Range on Protein: 6-75
Range on HMM: 2-73/282.0
SVLIDLSGTIHIEEFAIPGAQTALELLRQHAK-VKFVTNTTKESKRLLHQRLINCGF-KVEKEEIFTSLTAA
.||.|  | |   | |..||   ...| .. | | |||| .. ..  . ...   || .| .|.||.|   .
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycs
subfamily_LHPP_pd Subfamily LHPP 7-232 2e-101 329.7 In-house 1-226 (227) alignment 
Range on Protein: 7-232
Range on HMM: 1-226/227.0
VLIDLSGTIHIEEFAIPGAQTALELLRQHA-KVKFVTNTTKESKRLLHQRLINCGFKVEKEEIFTSLTAARDLIVKNQYRPFFIVDDRAMEDFEGISTDD
||.||||..|.|..|||||..||. |||.. ||.||||||||||| |..|||..||.||.|||||||.|||.|. ....||...|.|...||||.|.||.
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedidtdk

PNAVVIGLAPEKFNDTTLTHAFRLIKE-KKASLIAINKGRYHQTNAGLCLGPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSLneNVDFSSAVMIGDD
|||||||||||.|...||..||||..| |||.|||||||.|.... ||.||||..|..|||..||.|..||||..||||.||..|  .|| ..|||||||
pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleel..gvdpeeavmiGDd

VNDDALGAIKIGMRAILVKTGKFRDGDE
|.||  ||.|.|.|..||||||||..||
vedDveGAlkaGlrgvlVktGkfrpede
Hydrolase_6 Haloacid dehalogenase-like hydrolase 7-95 2e-16 51.3 Pfam-A 1-92 (101) alignment 
Range on Protein: 7-95
Range on HMM: 1-92/101.0
VLIDLSGTIHIEEFAIPGAQTALELLRQH-AKVKFVTNTTKESKRLLHQRLINCGFKVEKEEIFTSLTAARDLIVK--NQYRPFFIVDDRAM
.|.|. |... .. |||||. ||. ||..  .| ..|| ...|.. ....| . |..|..|...|| |||.... |  .. . ..|. ..  
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrkadkkvlvigeeglr
subfamily_PGP_pd Subfamily PGP 7-84 4.8e-11 33.5 In-house 2-81 (279) alignment 
Range on Protein: 7-84
Range on HMM: 2-81/279.0
VLIDLSGTIHIEEFAIPGAQTALELLRQHAK-VKFVTNTTKESKRLLHQRLINCGFK-VEKEEIFTSLTAARDLIVKNQY
||.|  |.. ..| |||||  ||. |... | | ||||   .|.. | ... . ||. |..|||..|  |. | . ....
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqkkf
Chronophin_2 103-226 1.8e-15 47.9 In-house 123-244 (282) alignment 
Range on Protein: 103-226
Range on HMM: 123-244/282.0
TDDPNAVVIGLApEKFNDTTLTHAFRLIKEKKASLIAINKGRYHQTNAGLC-LGPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSLNenVDFSSAVMI
  | .||..|   ||.  . |..|   ... .  |.| ..  .|  . |    | |.  | || ..| .||..||| . .||   . ..  || . ..||
dpdvravlvgyd.ekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfs..vdparslmi

GDDVNDDALGAIKIGMRAILVKTGK
|| .. | |   . |. ..|  || 
gdrletdilfgsncglstvltltgv
subfamily_PGP_pd Subfamily PGP 104-232 1.2e-20 65.0 In-house 128-254 (279) alignment 
Range on Protein: 104-232
Range on HMM: 128-254/279.0
DDPNAVVIGLApEKFNDTTLTHAFRLIKEKKASLIAINKGRYHQTNAGLC-LGPGTYVAGLEYSAGVEATIVGKPNKLFFESALQSlnENVDFSSAVMIG
 | .|||.|.  ||..   |..| . ..|... ..| |. . .. . ...  |.|. || .| ..| .....||||.| .|. |..  |..|.. ..|||
kdvgAVvvgvd.eklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllek..eeidpertlmiG

DDVNDDALGAIKIGMRAILVKTGKFRDGDE
| .. | | . . |....|| .|  .  | 
DrlktDilfgkncGlqtLlvlsGvtkledv
DUF881 Bacterial protein of unknown function (DUF881) 119-193 1.7e-06 14.0 Pfam-A 42-114 (149) alignment 
Range on Protein: 119-193
Range on HMM: 42-114/149.0
NDTTLTHAFRLIKEKKASLIAINKGRYHQTNAGLCLGPGTYVAGLEYSAGVEATIVGKPNKLffESALQSLNENV
.|..| .    ...  |  |.||  |  .| |  | |. . | | ..|.  . ...|.|..|  ..||.  .. |
hdedllkvvneLraagAeaIsingqRivattaircaggtilvdgtkisppyvikaIGdpdtL..aaalnikggvv
CECR5_TIGR01456 171-252 2.2e-08 23.9 In-house 266-361 (370) alignment 
Range on Protein: 171-252
Range on HMM: 266-361/370.0
ATIVGKPNKLFFESALQSL-----------NENVDFSSAVMIGDDVNDDALGAIKIGMRAILVKTGKFRDGDELK---VKNVANSFVDAVNMIIEN
 . .|||.|| .. | . |           .    | .  |.||.   |  || . |.  |||||| . ..||||    . | .|  .||. |.| 
yellGkPskltydyaedvlidiekrlagrkgsaapfkklymvGDnPasDiiGarnaGlfsilvktgvydgadelkegkarlvvdsvseavikiLek
Hydrolase_like HAD-hyrolase-like 174-241 1.7e-18 57.7 Pfam-A 2-67 (75) alignment 
Range on Protein: 174-241
Range on HMM: 2-67/75.0
VGKPNKLFFESALQSLneNVDFSSAVMIGDDVNDDALGAIKIGMRAILVKTGKFRDGDELKVKNVANS
 ||||. ....||. |  ....|..|||||....| ..| ..|.|.|||.|| .|..|  . |  .. 
lgKPnpgmydkalevl..gappsevvmiGDslatDieaAnnaGirsilVltGvsreedlklakakpdy