Gene M01A12.4 in Caenorhabditis elegans

Synonym: CELE_M01A12.4, M01A12.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP124_AA protein Get Run
CeleP124_AA_3-184 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 1-192 6.9e-144 470.3 In-house 84-275 (275) alignment 
Range on Protein: 1-192
Range on HMM: 84-275/275.0
MWIYNVQTVVCLVSPEEAGGYFVPKEGETFTSFQKYQMKTIGIFDEKQGVTVYQCELKSYKAPKKLNRRMIYIICCDTSVGSIRSPRQQTVIMEYMWAFE
.||||||||||||.|||||||||||||||||||||||.||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||
lwiynvqtvvclvlpeeaggyfvpkegetftsfqkyqiktigifdekqgvtvyqcelksykapkklnrrmvyiiccdtsvgsirsprqqtvimeymwafe

EANAIENGVALADAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRKHDFFSSIYTFFAFCVQCSAVSETD
|||||||.|||||||||||||||||||||||||...||||||||||.|||||||||||||||||||||||||||.|||||||||.|||||||
eanaienevaladakttvlvhaiagtrrcasfvvaavmckqlleagqfsametwfemrkrrahtctrkhdffssvytffafcvqssavsetd
0040438 (Phosphotyrosine protein) phosphatases II 1-199 3e-22 74.7 In-house 106-292 (317) alignment 
Range on Protein: 1-199
Range on HMM: 106-292/317.0
MWIYNVQTVVCLVSPEEAG-----GYFvPKegETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYkapKKLNRRMIYIICCDT-SVGSIR-SPRQQTVIM
.| ..|...|.|...|| |      |. |   .... . ..........  ..|.|... |.. .   .. . |....... .   ...  ||..   ..
vweqgvtvivmLteleelgrekcaqYw.pl..getltygdftvtllseee.lagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfl

EYMWAFEEanaiengvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRaHTCTRKHDFFSSIYTFFAFCVQCSAVSETDE
|..... |           | .. ||||  ||  |...|.|  .|. || . |.... |.. |.|..| . .    ...  .|.. .. ...  ..| . 
eavreale...........dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR.pgavqtpeqyrflydalleylkrkltlepas

NYVKSM
.... .
elklkl
0036941 (Phosphotyrosine protein) phosphatases II 1-188 9.8e-21 69.8 In-house 98-282 (297) alignment 
Range on Protein: 1-188
Range on HMM: 98-282/297.0
MWIYNVQTVVCLVSPEEAGG-----YFVPKEGETFTsFQKYQMKTIGIFD-EKQGVTVYQCELKSYKAPkklNRRMIYIICCDTSVgSIRSPRQQTVIME
.| .||...|.|....| |      |. ..|||..| . .........   .....|....|.. .. .   . |....... .       |   . ...
vweqnvtvIvmltelvelgrekcaqywpleegeslt.ygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwp.dhgvpespaslld

YMWAFEEANAIEngvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLL---EAGNFSAMETWFEMRKRRAHtCTRKHDFFSSIYTFFAFCVQCSAV
..........          .. ||||  ||  |...|.|  .|. ||    . |...  |.. ..|..|.. .    ...  .| .... ...  .
fielvrkvlkll......psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.avqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 1-178 2.9e-19 65.0 In-house 97-267 (273) alignment 
Range on Protein: 1-178
Range on HMM: 97-267/273.0
MWIYNVQTVVCLVSPEEAGG-----YFVPKEGETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKklnRRMIYIICCDTSVgSIRSPRQQTVIMEY
.| .||...|.|....| |      |. ...||... . |.. ......  |...||.. ||.... ..    |....... .       | . . ..|.
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge...srtvthfhytgwp.dhgvppslesllef

MWAFEEANAI--ENgvaladakTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHtCTRKHDFFSSIYTF
... ..|..   .|        ..|.||  ||  | ..|.|  ... || . |.... |..  .|..| . .    ...  .| .
ielvrkalealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg.mvqtpeqyrflyea
0050432 (Phosphotyrosine protein) phosphatases II 1-173 4.4e-19 64.4 In-house 128-290 (308) alignment 
Range on Protein: 1-173
Range on HMM: 128-290/308.0
MWIYNVQTVVCLVSPEEAGG-----YFVPKEGETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKKlnrRMIYIICCDTSVgSIRSPRQQTVIMEY
.| .||...|.| ...| |      |. ...|.... . |.. ... .   ....||.. ||. .. ..    |....... .       | . . ....
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdges...rtvthfhytnWp.dhgvPpspeilldf

MWAFEEANaiENgvaladakTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRKHDFFS
... .. .  ..         ...||  ||  |.. |.|  ... || . |.... |..  .|..|..  . .  .. 
lelvrksl..pg........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylf
0043336 (Phosphotyrosine protein) phosphatases II 1-180 2e-18 62.3 In-house 108-274 (278) alignment 
Range on Protein: 1-180
Range on HMM: 108-274/278.0
MWIYNVQTVVCLVSPEEAGG----YFVPkegETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKKlnrRMIYIICCDTSVgSIRSPRQQTVIMEYM
.| ..|.|.|.|....| |     .. |   .... . ... .....   ....||.. |.. .. ...   |.......         | . . .....
vwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdges...rtvthyhylgwp.dhgvpeslsllldfl

WAFEEANAiengvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRaHTCTRKHDFFSSIYTFFA
.|. ||..        | .. ||||  ||  |.. |.|  ... ||   |.... |.. |.|..| . .    ...  .| . .
kavreale........dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.pgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 1-180 2.4e-18 62.1 In-house 74-243 (249) alignment 
Range on Protein: 1-180
Range on HMM: 74-243/249.0
MWIYNVQTVVCLVSPEEAG----GYFVPKegETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMIYIICCDtSVGSIRSPRQQTVIMEYM
.| ......|.| |..| |      . |   .... . ... ... .   |...||.. ||. .. ....  . |... .    |   |. .   ..|..
lwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieav

WAFEEANaiengvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHtCTRKHDFFSSIYTFFA
. . |..         . .. ||||  ||  |.. |.|   |. || . ..... |.. ..|..| . .    ...  .| . .
rkaleel.........pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpg.avqnpeqyrflyeall
0051299 (Phosphotyrosine protein) phosphatases II 1-170 5.4e-18 60.9 In-house 112-274 (288) alignment 
Range on Protein: 1-170
Range on HMM: 112-274/288.0
MWIYNVQTVVCLVSPEEAG----GYFVPKegETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMIYIICCDTSVGSIRSPRQQTVIMEYM
.| .||...|.| ...| |     .. |   .... . ... ... .   ....||.. |.. .. ... .   .... . |.      |   . .....
vweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

WAFEEANAiengvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRKHD
 .. .|.|        . . .|.||  ||  |.. |.|  ... ||.. | ....|..  .|..| . ..    
rlvrkala........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
0039614 (Phosphotyrosine protein) phosphatases II 1-178 6.8e-18 60.6 In-house 121-284 (297) alignment 
Range on Protein: 1-178
Range on HMM: 121-284/297.0
MWIYNVQTVVCLVSPEEAG----GYFVPKEGetftSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPkklnrRMIYIICCDTSVgSIRSPRQQTVIMEYM
.| ..|...|.| ...| |     |. ...|     . ... ......  ..|.||.. |.. .. .     |... ...         |   ....| .
vweqgvtvivmLtklvelgrkcaqywpeegg....tygdftvtllkveh.ldgytvrtlevtnnges.....rtvthfqytgwp.dhgvppslelllefl

WAFEEANAIEngvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRkHDFFSSIYTF
 . .||.|        . .. ||||  ||  |...|.|   |. || . |.... |.. |.|..| . ..   ...  .| .
elvrealael......pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt.psqyrflyda
Y_phosphatase Protein-tyrosine phosphatase 2-171 6.3e-22 73.5 Pfam-A 63-226 (235) alignment 
Range on Protein: 2-171
Range on HMM: 63-226/235.0
WIYNVQTVVCLVSPEEA----GGYFVPKEGETFTSFQKYQMKTI-GIFDEKQGVTVYQCELKSYKAPKklNRRMIYIICCDtSVGSIRSPRQQTVIMEYM
| ..|...|.|.| ||       ...|.| |............   . ......|....|||. |...  ..|... . .  .      |.... .....
wqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees..ekrevkqlhyt.nWpdhgvpespkslldli

WAFEEANaiengvalADAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRKHDF
...|. .        .. .. |.|| .||. |...||| .....|| . .... .... |.||.|.. ... . .
rkveksk........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 2-171 6.3e-22 73.5 In-house 63-226 (235) alignment 
Range on Protein: 2-171
Range on HMM: 63-226/235.0
WIYNVQTVVCLVSPEEA----GGYFVPKEGETFTSFQKYQMKTI-GIFDEKQGVTVYQCELKSYKAPKklNRRMIYIICCDtSVGSIRSPRQQTVIMEYM
| ..|...|.|.| ||       ...|.| |............   . ......|....|||. |...  ..|... . .  .      |.... .....
wqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees..ekrevkqlhyt.nWpdhgvpespkslldli

WAFEEANaiengvalADAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRKHDF
...|. .        .. .. |.|| .||. |...||| .....|| . .... .... |.||.|.. ... . .
rkveksk........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
0045450 (Phosphotyrosine protein) phosphatases II 2-177 4.4e-18 61.5 In-house 128-298 (307) alignment 
Range on Protein: 2-177
Range on HMM: 128-298/307.0
WIYNVQTVVCLVSPEEAGG----YFVPKEgETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYkAPKKLNRRMIYIICCDTSVGSIR-SPRQQTVIMEYM
| ..|...|.| ...| |      . | | ...  . .........   ..|.||.. |.. .  ...  |. ..... .   ...  |. .   ..|..
weqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieev

WAFEEAnaiengvalADAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGN---FSAMETWFEMRKRRAHTCTrKHDFFSSIYT
... |.          . .. ||||  ||  |...|.|  .|..|| . |    ... |.. ..|..| . ..   ...  .| 
rkalee.........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq.npeqyrflye
0042113 (Phosphotyrosine protein) phosphatases II 2-176 1e-17 59.9 In-house 73-236 (245) alignment 
Range on Protein: 2-176
Range on HMM: 73-236/245.0
WIYNVQTVVCLVSPEEAGG----YFVPKegETFTSFQKYQMKTIGIFDeKQGVTVYQCELKS-YKAPKKLNRRMIYIICCDTSVGSIRSPRQQTvimeym
| ....|.|.| ..|| |      . |   .... . .........   ....||.. |..  .. ... .... |. . | .| .. .  ..       
welgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldf......

wafeE--------AnaiengvalaDAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTrKHDFFSSIY
             .          |....||||  ||  |.. |.|   |. || . ...|. |.  |.|..| . ..   ...  .|
....lefvrkalae..........dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavq.tpsqyrfly
DSPc_SM00195 2-183 6.6e-17 57.1 In-house 90-262 (263) alignment 
Range on Protein: 2-183
Range on HMM: 90-262/263.0
WIYNVQTVVCLVSPEEA----GGYFVPKEGETFTSFQKYQMKTIGIFDEKQGVTVYQCELKSYKApkkLNRRMIYIICCDTSVGSiRSPRQQTVIMEYMW
|  .|...|.|...||        ..|.| .. . |.|.. |..    .|. ..... ||.  .     . | .. . . .   .   | ... ..|.. 
weekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellr

AFEEANAIEngvaladaKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHtCTRKHDFFSSIYTFFAFCV
|... .  .        .....||  ||  |...||........| |  ...  |.. |.|| |.. . ....... ||. .....
avkksksts........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfiyeaileyi
PTPc_SM00194 2-183 6.6e-17 57.1 In-house 90-262 (263) alignment 
Range on Protein: 2-183
Range on HMM: 90-262/263.0
WIYNVQTVVCLVSPEEA----GGYFVPKEGETFTSFQKYQMKTIGIFDEKQGVTVYQCELKSYKApkkLNRRMIYIICCDTSVGSiRSPRQQTVIMEYMW
|  .|...|.|...||        ..|.| .. . |.|.. |..    .|. ..... ||.  .     . | .. . . .   .   | ... ..|.. 
weekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellr

AFEEANAIEngvaladaKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHtCTRKHDFFSSIYTFFAFCV
|... .  .        .....||  ||  |...||........| |  ...  |.. |.|| |.. . ....... ||. .....
avkksksts........sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfiyeaileyi
0046845 (Phosphotyrosine protein) phosphatases II 2-181 1.6e-15 52.7 In-house 98-272 (284) alignment 
Range on Protein: 2-181
Range on HMM: 98-272/284.0
WIYNVQTVVCLVSPEEAG----GYFVPKEgETFTSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMIYIICCDTSVGSIRSPRQQTVIMEYMW
| .||...|.| ...| |     .. | | ...  . ... ... .   |...||.  ||. .. ...  . ... .      |   ||..   ..... 
weqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

AFEEAnaiengvalADAKTTVLVHAIAGTRRCASFVATSVMCKQLLEAG---NFSAMETWFEMRKRRAHtCTRKHDFFSSIYTFFAF
 . |.          . . ...||  ||  | . |.|  ....|| . |   .... |..  .|..| . .    . .  .| ....
ellen.........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg.mvqtleqyrfvyealle
0045098 (Phosphotyrosine protein) phosphatases II 2-180 1.6e-12 42.9 In-house 85-269 (278) alignment 
Range on Protein: 2-180
Range on HMM: 85-269/278.0
WIYNVQTVVCLVSPEEAG-----GYFVPkegETFTSFQKYQMKTIGIFDEkqgVTVYQCELKSYKA---PKKLNRRMIYIICC-DTSVGSIRSPRQQTVI
| ......|.| . .| |      |. .   . .  . ... ... .       ... . |. .     .. |  | ......     ... |    . .
welgitvivmltelvelgrekcaqywpe...ggsltygdftvtllseevl...ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksf

MEYMWAFEEANAIENGV-----ALADAKTTVLVHAIAGTRRCASFVATSVMCKQLlEaGNFSAMETWFEMRKRRAHTCTRKHDFFSSIYTFFA
 |..   .||..  ...      | | ...||||  ||  | . .||   |...| | |.... |.  |.|..| ...    ...  .| | .
lellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefll
0044763 (Phosphotyrosine protein) phosphatases II 2-169 1.3e-08 30.2 In-house 45-158 (178) alignment 
Range on Protein: 2-169
Range on HMM: 45-158/178.0
WIYNVQTVVCLVSPEEA-----GGYFVPKEGetftsfqkyqmktigifdekqgvtvyqcelksykapkklnRRMIYIICCDTSVGSIRSPRQQTVimEYM
. ......|.| .. |        |.. ..|                                         ....| . | .| ....  ...|  |..
kelgithivnlteelelgflkcdpywpeeag........................................iqylhipipDhgvpdllehflefv..efi

W--AfeeanaiengvalADAKTTVLVHAIAGTRRCASFVATSVMCKQlleagNFSAMETWFEMRKRRAhTCTRKH
                 .. . .||||  ||  | ...||   |.|.     ..|. | . ..|.||   ... .
eeal.............dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg
0049772 (Phosphotyrosine protein) phosphatases II 2-175 1.2e-07 27.2 In-house 117-266 (314) alignment 
Range on Protein: 2-175
Range on HMM: 117-266/314.0
WIYNVQTVVC---------------------LVSPEEAGGYFVPKEGETFTsfqkyQMKTIGIFDEKQGVTVYQCELKSYKAPkkL--Nrrmiyiiccdt
. .|| ..|.                     | .. . |.. .... |..      .  . . . |..|...... .  . ||  |              
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.....eelydpelferlgikylripvpDgsap..lled...........

svgsirsprqqtvimeymwaFEEANAIENGValaDAKTTVLVHAIAGTRRCASFVATSVMCKQLleagNFSAMETWFEMRKRRAhtCTRKHDFFSSI
                    |.|. .. . .   |... ||||  ||  | ..||..  ..|.|    ..|. |.. ..|..|   .  .. |. . 
....................fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp..inpnpgfieql
0037934 (Phosphotyrosine protein) phosphatases II 4-179 2.3e-11 39.2 In-house 71-238 (243) alignment 
Range on Protein: 4-179
Range on HMM: 71-238/243.0
YNVQTVVCLVSPEEAGGY----FVPkeGETftSFQKYQMKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMIYIICCDTSVGSIRSPRQQTVIMEYMWAF
......|.| ...| | .    . |  ||.   . ... .....   ....||.  .|. .....     . |   .    |   || .   .......|
lgitvivmltelvElgrekcaqywp..gev..tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevref

EEANAienGVALADAKTTVLVHAIAGTRRCASFVATSVMCKQLleagNFSAMETWFEMRKRRAHTCTRKHDFFSSIYTFF
 |.      .  .| . .||||  ||  | . ..|  .|...|    .... |.. ..|..| . .    ...  .| . 
ieell...sllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal
0041856 (Phosphotyrosine protein) phosphatases II 4-179 6.3e-09 31.2 In-house 57-168 (182) alignment 
Range on Protein: 4-179
Range on HMM: 57-168/182.0
YNVQTVVCLVspeeaggyF----VpkegetftsfqkyqmktigifdekqgvtvyqcelksyKAPKKLNRRMIYIICCDTSVGSirsprqQTVIMEYMWAF
....|.|.|                                                    .  ..|. . .|. . | .| .         . ... . 
lgittivnlt........eelywp.....................................ellerlgiqylylpwpDhgvpd......ldelldfieev

EEanaiengvaladAKTTVLVHAIAGTRRCASFVATSVMCKQlleagNFSAMETWFEMRKRRAHTCTRKHDFFSSIYTFF
.|             . .||||  ||  | ...||  .|.|.     ..|. |.. ..|.|| . ... . .|   .  .
le............eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlall
0049260 (Phosphotyrosine protein) phosphatases II 4-166 1.3e-07 26.9 In-house 32-134 (152) alignment 
Range on Protein: 4-166
Range on HMM: 32-134/152.0
YNVQTVVCLVSPEEAGGYFVPKEGetftsfqkyqmktigifdekqgvtvyqcelksykapkklnrRMIYIICCDTSVGSIRSPRQQTVIMEYMWAFEEAN
....|.|.| ...| | .....                                           . ... . | .| ..    .. ...   .| .. .
lgittivmltellelgklkceqyi.........................................qylhlpwpDhgvpdlsqlllflllfieklaldkgg

aiengvaladaktTVLVHAIAGTRRCASFVATSVMCkqlleaGNFSAMETWFEMRKRRAHTCT
             .||||  ||  | . .||   |.       ..|. |.   .|..| . ..
.............pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavp
0036282 (Phosphotyrosine protein) phosphatases II 4-166 6.8e-07 24.6 In-house 35-154 (174) alignment 
Range on Protein: 4-166
Range on HMM: 35-154/174.0
YNVQTVVCLVSPEEAGGYFVPKEGETftsfqkyqmktigifdekqgvtvyqcelkSYKAPKKLNRRMIYIICCDTSVGSIRSpR-QQTVIMEYMWafeea
....|||.| ...| | | ..    .                              .. ...|. . .|. . | .| ..     .   ..|        
lgittvvmlleekelglykcinywpe.............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.....

naiengvaLADAKTTVLVHAIAGTRRCASFVATSVMCKQLLeAGNFSAMETWFEMRKRRAHTCT
        . | . .||||  ||  | . .||   |...||  .   |...  |.|. | . ..
........sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq
0046846 (Phosphotyrosine protein) phosphatases II 4-165 1.2e-06 23.9 In-house 46-155 (176) alignment 
Range on Protein: 4-165
Range on HMM: 46-155/176.0
YNVQTVVCLVSPEEAGGYFVPKEGETFTSFQKyqmktigifdekqgvtvyqcelksykapkklnrrmiyiiccdtsvgsirspRQQTVIMEYMWAFEEaN
.....||.| .. | | . .|   . .....                                                    . . . .. ... .  .
lgitavvnlteevelgrlkcpnywpeleklgi...................................................qylhlpwpDhgvpdl.e

AIENGVALADAK----TTVLVHAIAGTRRCASFVATSVMCKQlleaGNFSAMETWFEMRKRRAHTC
.... ... .       .||||  ||  | . .||   ....     ..|. |.  ..|..| . .
lllellefirealkeggpvlVHCsaGigRtgtlvaayllele....kglsveealalvreqRplga
0043147 (Phosphotyrosine protein) phosphatases II 4-166 1.4e-06 23.7 In-house 43-145 (172) alignment 
Range on Protein: 4-166
Range on HMM: 43-145/172.0
YNVQTVVCLVSPeeaggyfvpkegetftsfqkyqmktigifdekqgvtvyqceLKSYKAPKKLNRRMIYIICCDTSVGsirSprqqtvimeyMWAFEEAN
......|.| .                                          |. ..  ..|. . .|. . | .|    .          .  ..|. 
lgithivnltel.........................................lydpellerlgiqylylpwpDhgvp...l..........lelllefl

AIENGVALADAKTTVLVHAIAGTRRCASFVATSVMCkqlleaGNFSAMETWFEMRKRRAHTCT
 . . ... . . .||||  ||  | . .||   |.       ..|. |.  ..|..| . ..
efidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 31-164 2.9e-06 21.6 In-house 129-250 (274) alignment 
Range on Protein: 31-164
Range on HMM: 129-250/274.0
TSFQKYQMKTIGIFdEKQGVTVYQCELKSYKAPKKlnrrMIYIICcdTSVGSIRSPRQQTVIMEYMWAFEEANAIENGVaLA-DakttvLVHAIAGTRRC
  ... ..|. .|  |... .| .  ||. . ...    ....    |.    .||.. . ... .   ||..  ||   ||       .||  ||  | 
erygdveikvekiv.erndysvrklvlkylerers....vkhywy..tdWPdhksPddantlldlvleveesreeenak.lapv.....vvhCsaGiGrt

ASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHT
  |.|.|. ..|| | .    ...  ..|  |   
GcfiaisiavrqlreeivvdvlkivcnlrldrGGm
0048076 (Phosphotyrosine protein) phosphatases II 74-168 1.2e-06 23.8 In-house 36-129 (145) alignment 
Range on Protein: 74-168
Range on HMM: 36-129/145.0
ICCDTSVGSIRSPRQQTVIMEYMWAFEEANAIENGVALAD----AKTTVLVHAIAGTRRCASFVATSVMCKqlleaGNFSAMETWFEMRKRRAHTCTRK
......  .    . . . .. . ... .. ... ... .    ..  ||||  ||  | ...||  .| .      ..|. |.. ..|..| . ... 
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnp
PTPc_DSPc_SM00012 84-175 3.4e-14 48.3 In-house 14-100 (105) alignment 
Range on Protein: 84-175
Range on HMM: 14-100/105.0
RSPRQQTVIMEYMWAFEEANAIENGvaladaKTTVLVHAIAGTRRCASFVATSVMCKQLLEA-GNFSAMETWFEMRKRRAHTCTRKHDFFSSI
  |.... |.|...|... .  ..       .. |.||  ||  |.. ||| .....|| .  ....  ... |.||.|...........  .
gvPeesdsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly
subfamily_Ptp69D_pd Subfamily Ptp69D 84-177 2e-06 22.2 In-house 196-280 (307) alignment 
Range on Protein: 84-177
Range on HMM: 196-280/307.0
RSPRQQTVIMEYMWAFEEANAIEngvaladaKTTVLVHAIAGTRRCASFVATSVMCKQLLEAGNFSAMETWFEMRKRRAHTCTRKHDfFSSIYT
  |.. . .....   .| .  .        .. ..||  ||. | . ||| ... .|| .  . . .||  ..|..|    .. .  .. .| 
kvPevargllklieqvrelykln........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleq.Yvflyr
0048179 (Phosphotyrosine protein) phosphatases II 98-167 4.5e-06 22.0 In-house 75-130 (144) alignment 
Range on Protein: 98-167
Range on HMM: 75-130/144.0
AFEEAnaiengvalADAKTTVLVHAIAGTRRCASFVATSVMCkqlleAGNFSAMETWFEMRKRRAHTCTR
..|||          . .  ||||  ||  | ...||  .|        ..|. |.. ..|.|| . .. 
fieea.........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpn