Gene M04G7.2 in Caenorhabditis elegans

Synonym: CELE_M04G7.2, CELE_M04G7.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf13
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP125_AA protein Get Run
CeleP125_AA_252-528 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 241-519 1.3e-25 84.6 In-house 3-276 (303) alignment 
Range on Protein: 241-519
Range on HMM: 3-276/303.0
EETREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPgdpPSdlCTVFNHPVNNKKNRYSNIPCLDISRVQLKfkmpnknSTDYIHANYIRSPFLKRGyILTQ
|| .. .. | |..     ... ..|..  | ||   ||   .  .   | .|||. .. ||| |.|.|         . ||||.|.     |.  ||||
eekkqkwkllakrtldedaniavnefekvvsylp...ps..vsknqfvknmdknrfvdvicldhskvkls.......dssyihasyleldsskka.iltq

GPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHcCLQFDKFSV---NYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPE
 |   | ||||.|| ...   ...|    | ..      ||||    |.|.. |.   ..    . .  |   | .|      ..    .|.||  ..| 
lplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsips

S-SEVMLK-------ILRKIrARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
  |  ..|       .|||  . |||.|    .|.||.||.   | |  |.|.  .  |. . .  .|  ||  .|| | |. ... .| 
dgspkfvkqiwqlqsvlrky.sdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvr.ngrlhavqnlsqfsvvytlla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 243-531 6.9e-42 138.1 In-house 6-299 (310) alignment 
Range on Protein: 243-531
Range on HMM: 6-299/310.0
TREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLcTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmpNKNSTDYIHANYIRSPFLKRGYILTQGP
    | | ...| ....|. .. . ... .|  .  | | |   .  . .|||||.. ||| |||.||    .    |||||||... .|.  .| .|||
hhlkylkalenfiiateklgieglvkqyrkldakqdssl.tyeaykkymhknrysdvvcldtsrvklkid..ksryedyihanyvktnylrstficsqgp

KKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPR----NAHCCLQFDKFSVNYEDSTVNKSLVTT-RLNLSYEG-----ETRLITHWLWKEWPD
 . |  ||||||.|| . .|..||.  |  | ||  |.|     ... |..  ..|   |.  . .  ||    |.  .      .   ..   | .|||
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

WQVPESS--EVMLKILRKIraRSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQITE
  ||.     |  ..| ..  |  | |.|||||..| ....|...... ..    . |.......|.   ||  .||  ||..| .| . |  . ....|
rgvpdekchtvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrglkv.daeevktellk.sraiciqtelqyliidrvriifargetevae

E
.
k
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 244-521 1.9e-56 186.5 In-house 7-289 (298) alignment 
Range on Protein: 244-521
Range on HMM: 7-289/298.0
REAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPP---SDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQ
 | ...... .|  ..|..|  ...|| .|        ..  .| ..| |.|||||..|  || ||| |. .  ... .||| | .. .   .  .|.||
aedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrnafiatq

GPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHccLQFDKFSVNYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPES
.| .|| .|||||...|. ..|||| .  |... |. .|.| . .   ......|.   . .   |....|..| .   ..| . .  . .||| .||| 
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpen

SEVMLKILRKIRARS-----TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
.. .|..|||.||       .| ...|||||||||| .|..  |. ...  .. |. |.|  ||.. |...||| .||. |... |..
atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkk.rpgavqteeqYvfiyeavlea
subfamily_PTPRB_pd Subfamily PTPRB 246-521 4.8e-68 224.3 In-house 7-284 (293) alignment 
Range on Protein: 246-521
Range on HMM: 7-284/293.0
AYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKE
   . |... .. .. .   |..|...|     .  ... ...||..||||.||   | |||.|. .. .....||| ||||.    .| .| ||||  |
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLa.alkdesgsDYinanyipgynsprefiatqGPlpe

TRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCClQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKI
|. |||||.|......|||| | .|  ..|| ||.|.. . . .. . .|.   ... .  |.  |... | |.| .... .. |||. |||... .|..
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldf

LRKIRARS------TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
.|..| .       .| |.||||||||.||..|..  ||.|... .. ||  ||..|| . |.  ||| .||. | ...||.
vrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyv.difgivaelRee.RnllvqtekqYifihqcvldl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 249-528 1.6e-59 195.9 In-house 12-289 (290) alignment 
Range on Protein: 249-528
Range on HMM: 12-289/290.0
KLFKDFAMSSQKMTLDDFKQEFSN--LPGDPPSDL-CTVFNHPVNNKKNRYSNIPCLDISRVQLKfkmpNKNSTDYIHANYIRSpfLKRGYILTQGPKKE
. |. || .  |.. |.. .|. .   |  |   |   .|..  . ||||| ...| |..|| ||    .    ||.||||..   ||  .|||||. |.
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk....dGydGdyvhanyvkG..lkamfiltqGalkd

TRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTR-L--NLSYEGETRLITHWLWKEWPDWQVPESSEVM
|  |.|||. ||...||||||. .|  . ||..|.| ..   | | ...|    .. . . .  . |      .|    . |.  | |||  |. |.  .
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlal

LKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQI
|..|| .|  | | |.|||||.||.||..|.|..|| .     | |. ..|  ||   |..|||   ||... ..|||.|...| |
lrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkel.dlldlvralrn.srlnsvqvdiqylalveilldlGkdfkyi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 250-540 2.7e-41 136.5 In-house 6-299 (439) alignment 
Range on Protein: 250-540
Range on HMM: 6-299/439.0
LFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLC--TVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETR
 |..     .|   . ||..| ..    |   |  ..  .  .. |||| ..  .| .|| |. ..|    . || ||||.  . .. || |||||||| 
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlq.eipgvphshyinanyikGyyddklyiatqgpkkett

ADFWRMIWQENTTAIVMLCQFLETNRekcaeYFPRNAHCC-----LQFDKfSVNYEDSTVNKSLVTTRLNLSYEgeTRLITHWLWKEWPDWQVPESSEVM
 ||||......|. ||||....|. .     |.| .|..|     .. |.  ..  . ..    |  . . .     | . .. .  ||| .||  .  .
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdr.nielpnyvirgfkvfnerdttek..ertvlqfhyiawpdknvpaqashv

LKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDfGVAYKQITEELAE---
|. || | .        | |.||||||||.||..|..|||. ...   . ||| ||. ||   |   ||.| ||..|.. .|.  . | .|.  . |   
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkv.dikgivkvlrk.qrkqmvqalcqyvfiynavle.divyGdiavtidefkk

KFNSTY
.||. .
efnagf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 251-520 2.2e-49 162.9 In-house 7-281 (290) alignment 
Range on Protein: 251-520
Range on HMM: 7-281/290.0
FKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKN-STDYIHANYIRSPFLKRGYILTQGPKKETRAD
| .| .  ..   . |...|  |     .   || . . |...||..||   |  |. |. .  .|. . .||.| ||     |. ||.|||| ..| .|
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNaHCCLqFDKFSVNY-EDSTVNkSLVTTRLNLSYE---GETRLITHWLWKEWPDWQ-VPESSEVMLK
||..||||..|.||||..  | ...||  |.| .      ...||..  ...|.| . ....|..  .   |... .|..  . |..   |.. . ..| 
FWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

ILRKIR----ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
| . ..       |. |.|||..||||....|......  .|     |. |.. ..|.  .  |||| ||| .| ...| 
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi.dvfqvlksqRiq.kpgsvqtvqqyqgifqivlt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 251-521 2.8e-47 156.1 In-house 7-277 (287) alignment 
Range on Protein: 251-521
Range on HMM: 7-277/287.0
FKDFAMSSQKMTLDDFKQEFSNLPG-DPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRAD
| .|. . ..   ..||. |  |   .   |  |.   . |..|||...|   |  || ||     ..  ||| | .| .   |. .|....|  .|  .
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfidgykekkafiiaesPmfntarn

FWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHccLQFDKFSVNYEDSTVNKSLVTTRLNLSYEG---ETRLITHWLWKEWPDWQ-VPESSEVMLKI
||..|...| ||||||||  |...|.| .|.| ..   . . .....  . .||.. .  .|..  ..   ... .. .   .|..   |.|   ..| |
fWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvi

LRKIRAR----STPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
 ......     |. |.|||..||||....|......  .|  .. |. |.. . |.  .  |||| .||. | ...| .
eemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGvi.Dvfqvlksqriq.kpgsvqtveqykfindivley
subfamily_PTPRD_pd Subfamily PTPRD 252-521 2e-69 229.7 In-house 11-280 (564) alignment 
Range on Protein: 252-521
Range on HMM: 11-280/564.0
KDFAMSSQKMTLDDFKQEFSNLPGDpPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFW
|..  . ..    .|..|. ..    ..  ... |.|.| .||||.||   | ||| |. |.......||| |..| .   .. || ||||..|| .|||
kehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLs.kvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW

RMIWQENTTAIVMLCQFLETNREKCAEYFPRNaHcCLQFDKFSVNYEDSTVNKSLVTTRLNL--SYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKI
||.|..|.. |||| .  | ...||..|.| . .   ..... |. |...  .  . . ..|  . . |.| .... . .|||  |||| . .|...||.
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkv

RAR----STPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
||     . | |.||||||||.|| ..... |. |..  |. || |.|..|| . | | ||| .||. |....|..
ralnepdagPivVhCSaGVGRTGtfividamlerikeektv.Diyqyvkalr.kqRnamVqteeQYiFiheailea
0040438 (Phosphotyrosine protein) phosphatases II 253-523 1.5e-78 259.6 In-house 7-277 (317) alignment 
Range on Protein: 253-523
Range on HMM: 7-277/317.0
DFAMSSQKMTLDDFKQEFSNLPGDPPSdLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWR
.. .   |.    ...|| .|.  ...  ..|...|.| .||||..|...| |||.|.  ... ...|||.|.|.  | ||| .|.||||...| .||||
lalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsp.lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIWQENTTAIVMLCQFLETNREKCAEYFPRnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIR
|.|....| ||||... | .|||||.|.|      |....|.|.. . ..... . ..| ..  ...|.| .||. .. |||  ||.| . .|..|...|
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

AR----STPPVIHCSAGVGRSGTLMAVEIALQSIHTHFtLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGV
.     ..| ..||||||||.||. |....|. ....   .|....| .||   |. .|||..||. . ..||..  
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelre.qRpgavqtpeqyrflydalleylk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 253-521 1.4e-43 144.2 In-house 14-283 (297) alignment 
Range on Protein: 253-521
Range on HMM: 14-283/297.0
DFAMSSQK-MTLDDFKQEFSNLPGDpPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmPNKNSTDYIHANYIRSpfLKRGYILTQGPKKETRADFW
|||   || .  | |..||  ||        || .. || .|.||.||   | |||.|.    .. . ||. | ....   |  .| || |.|.| ||||
dfatlvqknrhtdvfseeflclpea.niqpqtvaekkvnfeksRYkniLPydssRvkLaiv.nddpdsDyvnasfvkg..nkhrlittqmPmkatvadfW

RMIWQENTTAIVMLCQFLETNReKCAEYFPRNAHCClqFDKFSVNYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPE--SSEVMLKILR
.|...|....|||| .  |... ||| |.. ..     | . ||  .  .  .  .   |... .    .|..  . . |||| .|..  | . .||.. 
amvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklis

KIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
 .|       ..| ..||.||||| | |....  .  .. .    || ..|..||   |   ||| .|| ......|..
evrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakre.kevdifglvkklr.qerpylvqtkeqykfvyvavlea
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 254-534 7.2e-207 679.3 In-house 1-281 (281) alignment 
Range on Protein: 254-534
Range on HMM: 1-281/281.0
FAMSSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRM
|||||||||||||||||||||||||||||||||.|||||||||.|||||||||||||.||||||||||||||||||||||||||||||||||||||||||
famssqkmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrm

IWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS
|||||||||||||||||||||||||||||||||||||||.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
iwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars

TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLLDFGVAYKQITEELAE
||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqiteelae
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 254-523 5.6e-49 161.4 In-house 14-290 (305) alignment 
Range on Protein: 254-523
Range on HMM: 14-290/305.0
FAMSSQKMTLDDFKQEFSNLPGDPPSDLCT-VFN----HPVNNKKNRYSNIPCLDISRVQLKfkMPNknSTDYIHANYIRSPFL-KRGYILTQGPKKETR
| . .  . .| ...|| .|      |.   .||      ..  ||||...|| | | |.|.   |.   .|||||||.  |.. .. .| .|||  .| 
fvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkld..kps..psdyihanyvgcpmipekrficaqgpldqti

ADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNyEDSTV------NKSLVTTRLNLSYEGETR-LITHWLWKEWPDWQVPESSE
 .|| |. |..   |||||. .|. . |||.|.|      |..    |  |. .       .  .  | |||.| |. .  . |  | ||||  ||    
defwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivv.envsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckl

VMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
  |..|  ||    | |.|||||.||.||..|.|  |. |      | . ..|  ||   || |.|.  ||. | .|.|.. .
tslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalr.dqrafsiqndvqylfihrvmlnyfl
0050432 (Phosphotyrosine protein) phosphatases II 255-525 1.1e-82 273.1 In-house 32-302 (308) alignment 
Range on Protein: 255-525
Range on HMM: 32-302/308.0
AM-SSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLkfkmpnKNSTDYIHANYIRSP--FLKRGYILTQGPKKETRADFW
.    ... |  ...||  |.  .|.  ..|...| | .||||..|...| ||| |      ....|||.|.|.. .   |.| .|.||||...| .|||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

RMIWQENTTAIVMLCQFLETNREKCAEYFPRNAH-CCLQFDKFSVNYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRK
||.|..|.. ||||... | .|||||.|.| . .  .|...||.|.. . .|... ... | |..  .||.| .||. .. ||| .||.| | .|..|..
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

IRAR--STPPVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAY
.| .  . | |.||||||||.||. |....|. ....   .|. ..| .||   |. .|||..||... ..||..   .
vrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReq.Rpgmvqtpeqylflyralleylklk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 255-524 5.3e-59 194.8 In-house 14-285 (319) alignment 
Range on Protein: 255-524
Range on HMM: 14-285/319.0
AMSSQKMTLDDFKQEFSNLPGDPPSDLcTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMI
 .  .. .   ...|| .| .  . .. .  ... |.|||||.||   | .||.|. ........||| |..| .   .. .| ||.|...|  |||||.
lkalastgetllekefkllkeavndtf.dsaskeenkkknryqnilaydrtrvvls.eldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

WQENTTAIVMLCQFLETNREKCAEYFPRNahCCLQFDKFSVNYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA
|.|..  .|||..  |  . |. .|.|..  .  .. .. |. |.    . ..  .|.|     | ||| ..|. ..|||| .|||..  .|..|..|| 
Weeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVA
      | | |.|||||||| || ......|. ..   .| |. ..||.|| | |   ||. .|| .|...||..  |
srektqsgPivvhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlR.tqRnimvqrpeqYkfiyealleavea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 257-521 5.2e-61 201.2 In-house 14-278 (288) alignment 
Range on Protein: 257-521
Range on HMM: 14-278/288.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQ
  .... ..|..|. .|.    ..  |. ...||.||||| ||  .|  ||.|| |.......||| |.|| .   |. || ||||  .|  |||.....
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklk.kleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

ENTTAIVMLCQFLETNREKCAEYFPRNAHcCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS---
..|. |||| ...| ...|| ||.| . .   .. .. |   .|   .. |. .| |  ... . ||.. .. ||| .||||.. .|..||..   .   
nktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

-TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
  | ..||||||||.|| .|.. ... .... .. |.  .|..||   ||  ||||.||. |..|||. 
tgpiivhCsaGvGrtgtFialdalidaveeedyi.DvagtvaklRkq.RallvqtlkqYefiyevllsl
subfamily_Ptp69D_pd Subfamily Ptp69D 257-541 1.6e-53 176.9 In-house 15-303 (307) alignment 
Range on Protein: 257-541
Range on HMM: 15-303/307.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQ
|... |   ...|. .|.    .  ..| ..  |. |||| .|   |  ||.|| |.. |...||| |..|..   |. .|  |.|  .|  ||||||..
srkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLk.kingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae

ENTTAIVMLCQFLETNREKCAEYFPRNahCCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEG-------ETRLITHWLWKEWPDWQVPESSEVMLKILRKI
 . | |||| .  |.||.||| |.| .     |...  |.. ..   .  .   |..|  .       ..| .. . ...|.| .|||... .||.....
qevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqv

----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVayKQITEELAEKFNSTYR
    .   .| |.||||||||||...|... || ...  .. || ..| .||   |   || |.||. ... |||.    .  |.|  ........
relyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkv.difetvkdLrsq.RnllvqsleqYvflyralldyss..ygdtdedvddledaie
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 257-521 1.6e-53 176.9 In-house 15-282 (305) alignment 
Range on Protein: 257-521
Range on HMM: 15-282/305.0
SSQKMTLDDFKQEFSNLPGDppSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKnSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQ
...... ....... .|. .  .. . | .. .|..|||...|  || .|..|. |  ..  .||| |.|. .   |  ||..||| |.| |||||.|..
earvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlkntvadfWrlive

ENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS
| .. ||||..  | ...||  |.| .     .|..|||. ....  . ... .|..|    . |.| ....   .|||  ||...  .|....... . 
ekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq

T-----PPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
      | ..||||||||.|. .||.|||. ...  .. |. ... .|| . |   ||||.||. .. .| . 
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevv.dvfevlkqlRsk.rmkmvqtldqYvflhdaldel
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 257-544 3.1e-53 175.8 In-house 9-302 (307) alignment 
Range on Protein: 257-544
Range on HMM: 9-302/307.0
SSQKMTLDDFKQEFSNLPGDPPSDLcTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQ
 . .. .. ...||..|    |  . ||     |..||||....| | .|. .||.     ..|||||||.      . .| .|||...|. .|| |. |
rtldkgvqalvdefrvlakktpegv.tveafsantdknryqdvkcqdkgrivvkfd...glasdyihanylgiaikpkkficaqgplentqysfwamaiq

ENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDK----FSVNYED----STVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRK
|.  ...|||. .|. . || .|.| .    | | .     ||.       .  .. .  | |.. . ...| |.|. |..|||  ||.     . .|  
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

IRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV-AYKQITEEL--AEKFNSTYRRSL
.|    | |.|||||||||||..|. .  . . .     |.|..|  ||   |  ..||  ||. . .|||.. .  ||.  |||  .....  | . |
vrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsq.rhyaiqteaqylylhrvlleyflelyketyeellltknyeekyakwl
subfamily_PTPN6_pd Subfamily PTPN6 257-523 4e-52 172.1 In-house 19-298 (306) alignment 
Range on Protein: 257-523
Range on HMM: 19-298/306.0
SSQKMTLDDFKQEFSNLPGDPPSDLCT--VFNHPVNNKKNRYSNIPCLDISRVQLKfkMPNKNSTDYIHANYIR--SPFLKRGYILTQGPKKETRADFWR
......  .|..|| .|  .  ..| .    ..| |..|||| ||   | .|| ||   |.   .||| ||||.  ..  .. || |||  ..| .||||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWr

MIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLqFDKFSVNYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKI
|.||||.. |||. . .| ..|||| |.| . .    . | ||.  ... ... .  .|..|    ..|.| . .. .|.|||  ||.. ...|. |...
mvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

RARS--------TPPVIHCSAGVGRSGTLMAVEIALQSIHTHF--TLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
....         | |.|||||.|| ||.. ..| |. |...   .  ||...|  .| . |   ||| ||| ...|..  .  
nrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvr.eqrsglvqteqqykfvykaikkyie
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 258-520 8.2e-50 164.3 In-house 14-274 (515) alignment 
Range on Protein: 258-520
Range on HMM: 14-274/515.0
SQKMTLddFKQEFSNLPGdPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
... ||  | .|| .||| |     || .  .| ||||| ||  .| .||.|.  . ..   ||. | ||.|    . || .|||.| .  ||||...||
nrhttl..fseefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklev.indnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqe

NTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS----
|.|.|.|. .  | .. ||..|.|      ..| ...|.          .  .|..  . ..| .| . ..||||  ||. .  .||......|      
nvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt

TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
 | .||||||||| | .....  .  ..|  .. |. ..|  .|   |   ||| .|| .|. ..|.
hpliihcsaGvGrtGvvisidsvvahakttrmv.dvfnfvtnirq.krpylvqtqeqyafiygavle
0036941 (Phosphotyrosine protein) phosphatases II 259-527 6.2e-80 264.0 In-house 8-282 (297) alignment 
Range on Protein: 259-527
Range on HMM: 8-282/297.0
QKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLkfkmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQEN
... |  ...||. |.   ..  ..|.. | | .||||..|...| .||.|     .....|||.|.|.  . ||| .|.||||...| .|||||.|..|
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

TTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTV--NKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA---
.| ||||... | .|||||.|.| .    |....|.|.. . .|  ... ... | ...  .||.| .||. .. |||  |||| . .|......|    
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

---RSTPPVIHCSAGVGRSGTLMAVEIALQSIHT--HFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKQ
   ...| ..|||||||||||. |....|| ...  .   .||...| .||   |. .||||.||. .  .||..   ...
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq.Rpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 259-520 1.3e-77 256.3 In-house 7-270 (273) alignment 
Range on Protein: 259-520
Range on HMM: 7-270/273.0
QKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLkfkmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQEN
..  |. ...||  |.  .|.  ..|...| | .||||..|...| ||| |     . ...|||.|.|.. . ||| .|.||||...| .|||||.|..|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

TTAIVMLCQFLETNREKCAEYFPRNAHC-CLQFDKFSVNYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA----
.. ||||... | .||||| |.| .     |...||.|.. . ..... ... | |..   ||.| .||.....||| .||.| | .|......|     
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--RSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
  ...| |.||||||||.||. |....|. ....   .|....| .||   |  .|||..||... ..||.
lpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsq.Rpgmvqtpeqyrflyealle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 259-519 4.9e-38 125.5 In-house 10-290 (301) alignment 
Range on Protein: 259-519
Range on HMM: 10-290/301.0
QKMTLDDFKQEFSNLPGDpPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMP-NKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
 ..  ..|......|     .. |||  .  |.. ||. ||  .|  |. || |   .. ...|| |.|| .   |. .| .||| |.| .||||.||||
aakhsnkfeeqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

NTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVT-----------------TRLNLSYEGETRLITHWLWKEWPDWQVPESSE
 ...|||...  |. ..|| .|.|.  .   .| .|.|   ...|  . |                   ... . . ... .. .   .||.  |     
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

VMLK-----ILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFtLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLL
 .|.     | |. .    | |.|||..|.|||. ..|.|.|          |. |..  .| . .   |.||.||. |..|. 
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrs.kpgaVtTLeqytsiydvid
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 259-523 6.1e-30 98.7 In-house 21-286 (302) alignment 
Range on Protein: 259-523
Range on HMM: 21-286/302.0
QKMTLDDFKQEFSNLPGD-PPSDLCTVFNHpvNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETR---ADFWRMI
....    |.|| ..     . . |..| .  | |||.  ..|.||  .|.|.     ..  .|..|  .  | |.|  ||.| ||...    ..||||.
ksldtaevkkefkkidtmkvdlekCkafkk..nlkknqsedvpildsnlvkle.....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmv

WQENTTAIVMLCQFLETNReKCAEYFPRNAHCCLQFDKFSVNYEDstVNKSLVTTrLNLSYE------GETRLITHWLWKEWPDWQVPESSEVMLKILRK
.||. . .|.| .  | ..    |.||...   ....|. ||     |.|.  ..  ....|       .. |..  . . |.. .||..   . |   |
fqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk..Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaak

I----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
.       . . ||    |.|| |..... .|.......   | ||.||  .| . |...|..|.||. .. .|| .. 
vfakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiR.sqRpravdslkQyvslyialllyik
0051299 (Phosphotyrosine protein) phosphatases II 260-521 2.9e-78 258.6 In-house 19-285 (288) alignment 
Range on Protein: 260-521
Range on HMM: 19-285/288.0
KMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENT
.  |  ...||  |.   |.  ......| | .|||||.|...| |||.|.  ... ...|||.|.||. . ||| .|.||||...| .|||||.|..|.
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLs.vldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

TAIVMLCQFLETNREKCAEYFPRnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS------YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR-
. ||||... | .||||| |.|   . .|......|.. . .|... ... | ..      ..||.| .||. .. ||| .||.| | .|..||..|   
rvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

---STPPVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
   . | |.||||||||.||. |....|. ....   .|. ..| .|| . |  .|||..||... ..||..
asgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlr.eqRpgmvqtpeqyrfvyealley
subfamily_PTPN13_pd Subfamily PTPN13 260-520 6.6e-51 168.2 In-house 7-267 (273) alignment 
Range on Protein: 260-520
Range on HMM: 7-267/273.0
KMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPnknstdYIHANYIRSPFLKR--GYILTQGPKKETRADFWRMIWQE
|.  .. ..|| .|    | | |.| ..  |..|||| |.   | .||.|. . .      || |..|. |  |    ||..|||  || .|||.|.|. 
kldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweq

NTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDK-FSVNYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR--
... |.|. .  |... ||  |.| ...  |.    . |. .. .  ...|  .|...    ||.| ..|  . .||| .|| |.. .|......|    
kaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

-STPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 ..| |.|||||.||||||......|. |.    . |.|.|| .||   | . ||| .||....|..|.
dagPivvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreq.rqgvvqtkdqyifvykaile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 260-523 1.6e-46 153.7 In-house 20-280 (315) alignment 
Range on Protein: 260-523
Range on HMM: 20-280/315.0
KMTLDDFKQEFSNLPGDPPSDLCtVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENT
  | . |||.. ..||     |  | ..  | .|||| ||   | ||||| . . |.. .||. ||.|     || || .|||. ..  ||||....|. 
astkngfkqdyesipggqlhpld.vakkienkqknryiniiaydksrvqlpl.lendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedi

TAIVMLCQFLETNREKCAEYFPRNahcCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS----TP
. |||| .  | ...|. .|.| .    . . |..|   .  ||. .    |   .. . | .  . .  ||| .||...  .... |...       ..
gkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvga

PVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
 |.||||||||.||.....  |. ...   . |. ...  .|   |   ||...|| .|...||.  |
ivvhcsaGvGrtGtfitldavldqaeae.naidvynfitgvrqn.rikmvqvaeqyqfiydalletfv
0043336 (Phosphotyrosine protein) phosphatases II 261-520 5.3e-75 247.7 In-house 17-275 (278) alignment 
Range on Protein: 261-520
Range on HMM: 17-275/278.0
MTLDDFKQEFSNLPGDPPsDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
     ...|| .|.  .. | ......| | .||||..|...| |||.|.  ... ...|||.|.|.  .  .|..|.|||| .|| .|||||.|....|
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsl.lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

AIVMLCQFLETNREKCAEYFPrnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA----RST
 ||||... | .|.|||.|.|      |....|.|.. . ....  ... |...  ..||.| .||. .. ||| .|||| . .|..|...|     ...
tivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsng

PPVIHCSAGVGRSGTLMAVEIALQSIHTHFtLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
| ..||||||||.||..|....|. ....   .|. ..|..||   |. .|||..||. . ..||.
pvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreq.Rpgavqtpsqyrflyealle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 261-523 3.2e-46 152.7 In-house 16-272 (288) alignment 
Range on Protein: 261-523
Range on HMM: 16-272/288.0
MTLDDFKQEFSNLPGDPPSDLCTVFNHpvNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
....  |.|. . | . . |  ..|    |  ..|| |.|. ||.||.|.      ..  ||.|| . |   ||  | .| | . |   .|.|. ...  
iaveglkkeyrdspneasidiidsfia..nptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdve

AIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFS--VNYEDSTVNKSLVTTRLNLSYEGETRL-ITHWLWKEWPDWQVPESSEVMLKILRKIRARSTPPV
 |||||..||  .|| ||||| .     .. ..   |  . . ..| .. . |. | |||..  . .  ..||.|  |||.    |..|  ...   | |
yivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPiv

IHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
.|.||||||.|||. . |||.|.  .  |  |......||   |  ..|| .||. .....|.  .
vhssaGvGrtgtlililialeslrlddfl.girsllaklree.rfkaiqtemqylyvhrcvleell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 262-520 1.2e-59 196.7 In-house 13-274 (281) alignment 
Range on Protein: 262-520
Range on HMM: 13-274/281.0
TLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
    |..|...|     ..  |  ... | .|||||||   | .||... .  ....|||| ||.. .   ...|| ||||  .. ..||.|.|... .|
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvt.pneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

IVMLCQFLETNREKCAEYFPRNAHcCLQFDKFSVNYEDSTVNKSLVTTRLNL-SYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKI---RAR--STP
|||. . .|... ||  |.| ...  |.. .. |. . .. ... .. ...|   .|||| ...  .. |||  ||.... .|.  ...   . .   .|
ivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

PVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 ||||||||||.|| .|.. ........ .  |.|..| .|| . |   |||. ||  ..|..||
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrke.rnlmvqtvvqyefvykavld
subfamily_PTPN9_pd Subfamily PTPN9 263-527 2.1e-61 202.6 In-house 15-295 (297) alignment 
Range on Protein: 263-527
Range on HMM: 15-295/297.0
LDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAI
    ..|. ..   |..   .......| .||||... |.| .||.|. |..... .|||.||..     |...| |||| |.|  |||||.|....  |
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvla.kvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR--------
||  ...|. | ||..|.| . . . .| ..||.  .  ...  ... |...   ..|.| .||.    |||. ||.|.. .|..|.|.| .        
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

--------STPP-VIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVAYKQ
        | || |.|||||.||.||.....|.|. ...  |. |. . |..|| | || |.|| .||.. .. .|.. .  |.
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtv.dvvetvkllr.tqrafsiqtpeqyefcylavleyalelka
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 263-521 1.5e-42 140.9 In-house 22-287 (325) alignment 
Range on Protein: 263-521
Range on HMM: 22-287/325.0
LDDFKQEFSNLPGDPPSDlCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMI--WQentT
 | | .||  || | .    .|  .| | .|||. |.  || ||| |. |  .. |.||| |.|.|.   |  .. .| |. .|  |.||..  |.   .
qdgfahefgllpsddgia.kkvamkpenkaknrfknvvaldksrvvletkk.ddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...c

AIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNL--SYEGETRLITHWLWKEWPDWQVPESSEVMLKILR-------KIRA
..|..   |... ..|| |.|..     .|  . |.          |  .|..    .|||| .  . .. |.|  |..    .. ||.       ...|
svvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

---RSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDF
    ||| ..||||||||.|.....  ||. . ..  . || . | .||   | . |.|  ||.||.. | ..
ntkastpilvhcsaGvGrtGvfislysalakvieesrv.difgfvkklrk.drpsmvetvdqyiliyealvea
0039614 (Phosphotyrosine protein) phosphatases II 264-521 5.4e-76 251.2 In-house 32-288 (297) alignment 
Range on Protein: 264-521
Range on HMM: 32-288/297.0
DDFKQEFSNLPGDPPSdlCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAI
  ...|| .|.  .|.  ......|.| .||||..|...| |||.|| ..   ...|||.|.|.  . | .| .|.|||| .|| .|||||.|....|.|
tllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

VMLCQFLETNReKCAEYFPRNAHcclQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA------RSTPP
|||... | .| |||.|.| .     ....|.|.. . ....  ... |.....||.| .||...  ||| .||.|.|..|..|...|       ...| 
vmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

VIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
..||||||||.||. |  ..|. ....   .|....|..||   |  .|||..||. . ..||..
lVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelr.eqRpgavqtpsqyrflydallel
0045098 (Phosphotyrosine protein) phosphatases II 264-522 1.7e-67 223.0 In-house 7-272 (278) alignment 
Range on Protein: 264-522
Range on HMM: 7-272/278.0
DDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQlkfkmpnknstDYIHANYIRSPflKRGYILTQGPKKETRADFWRMIWQENTTAIV
 |...|| .|.  .. . .|... . | .||||..|...| |||            |||.|.||...  .. .|.||||...| ||||||.|....|.||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitviv

MLCQFLETNREKCAEYFPRnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS------YEGETRLITHWLWKEWPDWQVPESS--EVMLKILRKIRA----
||....| .|||||.|.|   . .|....|.|.... .|..  ....|..       ...|.| .||. .. |||  ||...    .|..|. ||.    
mltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------RSTPPVIHCSAGVGRSGTLMAVEIALQSIhtHfTLPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLLDFG
             ...| ..||||||||.||| |. . |. .  .    |. ..|..||   .  .||.|.||. . ..||.. 
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 264-521 2.8e-58 192.2 In-house 5-267 (274) alignment 
Range on Protein: 264-521
Range on HMM: 5-267/274.0
DDFKQEFSNLPGDPPSDLCTVFNHpvnNKKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAI
 |...|| .|| . . .  .|| .   ..|||| .|   . ||| |. . .... ..|| ||||. .   .. |. ||||  .| |||||||.||... |
kdlekeflelPlnfdqeeldvfgs...qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMLCQFLETNREKCAEYFPRNAHC--CLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA-------RS
||| .. |.|..|||.||| . ..    ........ |. . ..    ..| |.|  ..| ..|... .||| ..|.. . .|.......        . 
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakl

TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
.| |.|||||.|| |  .|..||.. .. . .. |. .||..||.  |   ||| .|| ||...|  .
apvvvhCsaGiGrtGcfiaisiavrqlreeivv.dvlkivcnlrld.rGGmvqtseqyelihralcly
subfamily_PTPRA_pd Subfamily PTPRA 264-522 3.7e-58 192.0 In-house 32-295 (330) alignment 
Range on Protein: 264-522
Range on HMM: 32-295/330.0
DDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
  |..|| .||  |    . . ..  |..|||. ||   | ||| |  |   ....||| | .|     |  .| .||||.||  |||||||. ....||
klfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvke.GveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativ

MLCQFLETNREKCAEYFPRNAhcCLQFDKFSVNYED------STVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR----S
|| .. | ..|||| |.| .   .. . .  |. ||       || | ||.   . . | ..||.. . .. |||  ||  .  |||.|.|...     .
mltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa

TPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
 | |.||||||||.||.....  |. ...   . |. ..|..||   |.  |||..|| .|.||||.. 
gpivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlq.rpqmvqtdeqyefiykvlleyy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 264-520 1.1e-49 164.0 In-house 19-275 (315) alignment 
Range on Protein: 264-520
Range on HMM: 19-275/315.0
DDFKQEFSNLPGdPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
  | .|| .||. |.    .|  ...| ||||| ||  || .||.|.  . ..   ||| | ||.|    . || .|||.| .  |||||..||..|.||
alfseefhdlpd.PdiyrqrvaretinfkknryknilPldsarvklev.iddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttiv

MLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS----TPPVIH
|. .  | .. ||. |.| .     .| ...|.  .   .   |. .| .    |.| .| . ..||||  |.. .  .||......|       . ..|
mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

CSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
|||||||.| .....  .. |.      |. ..|  ||   |   ||| ..| .|. ..|.
csaGvGrtGvvisidevvaqikrt.rsvdvfnfvknlra.krpylvqteeeyafiydavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 264-522 2.7e-46 153.4 In-house 34-294 (319) alignment 
Range on Protein: 264-522
Range on HMM: 34-294/319.0
DDFKQEFSNLPGDPPSDL-CTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAI
  .. || ...  ...    |  | . |  |||. ||   | ..|.|.     .. .||| | ..     |  || .|||...| ||||||||. |...|
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerli.GeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLCqfletnREKCAEYFPRNAHccLQFDKFSVNYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIR------ARS
|.|       ..||..|.| ..    . ..| |. .  .  .  |   ..||    | . | || . .. |||  ||...  ......|.|         
vllt......kdkcsqywplkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

TPPVIHCSAGVGRSGTLMAVEIALQSIHtHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD---FG
.. |.||||||||.|. ..... |. .. .    |. ..|  ||   |   || | ||..|.  ||.   ||
anivvhcsaGvGrtGvyivldvlldrmk.eekqvdvynfvrdlrq.qrntlvqdlvqykfiysalleehlfg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 264-520 2.7e-33 110.0 In-house 10-275 (287) alignment 
Range on Protein: 264-520
Range on HMM: 10-275/287.0
DDFKQEFSNLPGDPpSDLCTVFN---HPVNNKKNRYSNIPCLDISRVQLKFKmPnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
|| ..|. .|  |       .|    .  . |||||...  .| .|| |  . . .  .||| |||. |   .  .| .|||   |  ||||........
ddvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsae.g.elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsa

AIVMLCQFLETNREKCAEYFPRNaHCCLQFDKFSVNYEDSTVNKSLVTT---RLNlSYEG-ETRLITHWLWKEWPDWQVPES----SEVMLKILRKIR--
..... . .|  | || .|.| . .  ..   .||   | .. .   ..   ||    |. |.|..    . .|||  .. .       .|.. ..|   
svitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhiela

---ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHtHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
   .   |.|.|...|.||||.|.|. . ..         |. ..| .||   ||| ||.  |. |... |  
rdasevGPlvvhddvGiGrsGillatlvlvsrle.dlGrvdvaavvirlrey.raalvqavvqlrllyealvt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 265-532 3e-60 199.0 In-house 21-292 (318) alignment 
Range on Protein: 265-532
Range on HMM: 21-292/318.0
DFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
 ...|. .|  .. .   .  ..|||..|||| ||   | .||.|. .  .....||| ||||     |. || .|.|  ||  |||||.|. |.. |||
llseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqml.egeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LCQFLETNREKCAEYFPRNAhcCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARS-----TPPV
| |  |  ..|.. |.| .     ...|  |. ....  ...|  ..... ..  |.| .  . . .|||  ||||.  .|...|....       .| |
ltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpiv

IHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKQITE--EL
.|||||||| |. .||.| |. |.   .. |. |.|..||   | . ||| .|| .|..|||..  .... ..  .|
vhCsaGvGrtGvfiavdillerikaealv.Dvfqtvkqlreq.rnlmvqtedqyefiydvllealasgdtevdasdl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 265-520 9.6e-39 127.9 In-house 21-234 (392) alignment 
Range on Protein: 265-520
Range on HMM: 21-234/392.0
DFKQEFSNLPGdPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
 | .|| .||| |.    || ....| ||||| ||  .| .||.|.  . . . .||. | ||.|   .. || .|||.  .  |||||..|||.|.|.|
lffeefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvklev.iddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

LCQFLETNrekcaeyfprnahcclqfdkfsvnyedstvnkslvttrlnlsYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR----STPPVIHC
. .. | .                                             ..| .. . . |||| .||. .  .||......|     . | .|||
vtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc

SAGVGRSGTLMAVEIALQSIHThFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
||||||.| .....  .   ..   . |. ..|. .|   |   ||| .|| .|.  .|.
sagvgrtgvvisidsvvahakk.trmvdvfnfvtnirr.krpymvqtkeqyafiygavle
0046845 (Phosphotyrosine protein) phosphatases II 266-525 3.1e-78 258.3 In-house 2-277 (284) alignment 
Range on Protein: 266-525
Range on HMM: 2-277/284.0
FKQEFSNLPGDPPSD--LCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYIRSP-----FLKRGYILTQGPKKETRADFWRMIWQEN
...||  |.   ..    ..|...| | .||||..|...| ||| ||   .. ...|||.|.|.. .       |. .|.||||...| .|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TTAIVMLCQFLETNREKCAEYFPRNaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR---
.. ||||... | .||||| |.| . . .|....|.|.. . .|... ....| |..   .||.| .||. ...||| .||.|.| .|..||..|     
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

---STPPVIHCSAGVGRSGTLMAVEIALQSIHTHFT--LPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAY
   . | |.||||||||.||. |....|. .... .   .|. ..|..||   |  .||||.||... ..||..   .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre.qRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 266-521 3.4e-76 251.4 In-house 2-261 (263) alignment 
Range on Protein: 266-521
Range on HMM: 2-261/263.0
FKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
.|.||..|    ... .|  ... |..||||.||.. | .||.|| . ..|...|||.||||. .  |. ||.||||...| .|||||.|.|... ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkke.ekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNK-SLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR----STPPVI
... | ..|||..|.|....   .|.|.||.  . .  | ..... |.|..||  ||| .|.. .|.||| .||.| . .|..||... .    |.| |.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRSGTLMAVEIALQSIHTHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
||||||||.||.....|.|........ .||..||..|| . |. .||||.||. | ...|..
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelR.kqRpgmvqtleqYlfiyeailey
PTPc_SM00194 266-521 3.4e-76 251.4 In-house 2-261 (263) alignment 
Range on Protein: 266-521
Range on HMM: 2-261/263.0
FKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
.|.||..|    ... .|  ... |..||||.||.. | .||.|| . ..|...|||.||||. .  |. ||.||||...| .|||||.|.|... ||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkke.ekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVNK-SLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR----STPPVI
... | ..|||..|.|....   .|.|.||.  . .  | ..... |.|..||  ||| .|.. .|.||| .||.| . .|..||... .    |.| |.
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRSGTLMAVEIALQSIHTHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
||||||||.||.....|.|........ .||..||..|| . |. .||||.||. | ...|..
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelR.kqRpgmvqtleqYlfiyeailey
0045450 (Phosphotyrosine protein) phosphatases II 266-521 2.3e-74 246.2 In-house 29-303 (307) alignment 
Range on Protein: 266-521
Range on HMM: 29-303/307.0
FKQEFSNLPGDPP--SDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYI--------RSPFLKRGYILTQGPKKETRADFWRMIW
...||  |.   .  .. ......|.| .||||..|...| .||.|.   .. ...|||.|.|.         .. ||| .|.||||..|| .|||||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

QENTTAIVMLCQFLETNREKCAEYFPRNaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA-
....|.||||... | .|||||.|.| .    |....| |.. . .. .... ..|...   ..||.| .||. ...||| .||.| | .|......|. 
eqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTL--PDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
     ...| ..||||||||.||..|  ..|. .... ||  .|. ..|..||   |  .||...||. . ..||..
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllr.eqRpgavqnpeqyrflyeallel
subfamily_PTPRG_pd Subfamily PTPRG 266-521 2.3e-50 166.4 In-house 21-286 (563) alignment 
Range on Protein: 266-521
Range on HMM: 21-286/563.0
FKQEFSNLPGDPPSD--LCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
|..|| .|     |.   ..  ..| | .||||.||   | |||.|.    .|.. ||| ||||     .. .| |||| |.|  |||||||..|.. ||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLCQFLETNREKCAEYFPRnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSY-----E---GETRLITHWLWKEWPDWQVPESSEVMLKILRKI-RARST
|. .. | .|.||  |.|.     .......|. ... |  .  . .| .       .    . .|.... . .||| .|||.|   |.  .|  .|. .
mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

---PPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
   | |.||||||||.||.....  |. |... .  .. ... |.|   |   |||  ||. ....||. 
eaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraq.RnflvqteEqYiflhdallea
subfamily_PTPRK_pd Subfamily PTPRK 266-524 4e-50 165.4 In-house 24-279 (314) alignment 
Range on Protein: 266-524
Range on HMM: 24-279/314.0
FKQEFSNLPGDppsdlCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
||.|. .|.         . ..  |..|||. .|   | |||.|.  . . .|.||| |..| |    . .| ||||..|| .||||....||...||||
fkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvfli.tidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivml

CQFLETNREKCAEYFPRNAHC--CLQFDKFSVNYEDSTVNKSLVTTRLNLSYEgETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARST----PPVIH
 .. |. | || .|.| ...    ..    ... .   |.. .  ..|. ..| |.|.. .. .  |||..|| | . .||..|.. . .     . |.|
telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqe.eirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVA
|||| ||.|| .|..| |. |... .. |. ..|  || . .   |.| .||..|. |.|.  ..
CsaGaGrtGtfiaidivldmieregvv.dvfnavktlrsr.kvnmveteeqykfiydvileaclc
subfamily_PTPN14_pd Subfamily PTPN14 266-521 1.1e-46 154.2 In-house 25-295 (300) alignment 
Range on Protein: 266-521
Range on HMM: 25-295/300.0
FKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKmpNKNSTDYIHANYIRSPF--LKRGYILTQGPKKETRADFWRMIWQENTTAIV
  .|. ..|      |... . |.|..|||. ..   . .||.|.    ..|||.|| |  |. .    .| || .||| . |  |||.|.|..... ||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelspt..kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MLCQFLETNREKCAEYFPRN--AHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA---R----
|| .  |  .||. .|||..   .  ..|.|| |  . |.  .|..|| |.| .   .| | . |  ...||| .|||  . .|. |.....   .    
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

------STPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
      . | ..||||||||.| |. ... ......  .. |||.....|| . |   |||| ||  ..|||. .
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneei.dikkvlarLr.eqrmllvqtlaqYkfvYkvliky
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 267-535 6.9e-51 167.8 In-house 25-300 (305) alignment 
Range on Protein: 267-535
Range on HMM: 25-300/305.0
KQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNknstDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
..||...      .    | .  ...|||| .. |||  ||.|.   |     .||||||. .|   . .| || | ..| |||| | .|..  || |||
raefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwph....eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc

QFLETNREKCAEYFPRNAHCCLQFD----KFSVNYEDSTVNKS-------LVTTRLNLSYEG-ETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARST
..||   .||.|||. . .  |.|.    | || .| |.  |        .  | | .   | ..| .||. | .|||  || .   .|..| | |.   
nllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskg

PPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQITEELAEK
| |.|||||.||.|... .|  |. . .   . | ..|. ..|   |  |.|| .||... .|.|..    | . ||  | 
pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkire.qrnnsiqtdaqylfvhqvilnyfrkkklldeevkea
subfamily_CG42327_pd Subfamily CG42327 268-451 6.6e-24 79.1 In-house 9-192 (319) alignment 
Range on Protein: 268-451
Range on HMM: 9-192/319.0
QEFSNLPgdppS-----DlctvfNHPV-NNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTT
.|| .||          |     . ||  ..|.|. |.  |  .|| |. ........ |..|.|.| .   .  || .| . ... .||||..|. .. 
eefrdlP....qliarad.....evPvtskdksrvinvvPlPetrvvlq.rigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsr

AIVMLCQFLETNREKCAEYFPRNAHC--CLQFDKFSVNYEDSTVNKSLVTTRLNLS-Y-EGETRLITHWLWkEWPDWQVPESSEVMLKILRKIRA
 || |..  |   ..||||.| ..       . .. |   .  |..  ... | |    . |.| .||. . .|.. .|| . . .. .| ..|.
vivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_PTPN3_pd Subfamily PTPN3 269-517 4.2e-51 168.5 In-house 20-270 (280) alignment 
Range on Protein: 269-517
Range on HMM: 20-270/280.0
EFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIR----SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
.| .|    |.  ... . | | .|||| .|   |. ||.||     ...|||| |||.     |  |   || |||| ..| .|||.|.|..... |||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk.....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LCQFLETNREKCAEYFPRNAHcCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA----RSTPPVI
| . .|  | || .|.|.. .  |.. .|||. | .  .|| |.  | |. .   | | |..  . .||| .||..|. .|......|.    ...| |.
lttlverGrvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKV
|||||.||.| |...|.||. | ..  .  . .||...|   ||. ||| .|| .. . 
hCsaGigrtGvlilletalalieaaepv.ypldivrtmr.dqramlvqtasqykfvCea
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 273-379 6e-09 29.9 In-house 21-127 (347) alignment 
Range on Protein: 273-379
Range on HMM: 21-127/347.0
LPGDPPSDlCTVFNHPVNNKKNRYSNIPCLDISRVQLKFKMPNKNS----TDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLcqf
| .  ||. .|. .   . .|||  .    | .|| |  .  ...       || | .|.    .. ||||| |  .|  |||.|.   . | .| .   
lanyspsk.ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti...

LETNREKCAEY
.|  .... | 
fepikdeaiee
0049772 (Phosphotyrosine protein) phosphatases II 277-524 1.1e-42 142.2 In-house 33-282 (314) alignment 
Range on Protein: 277-524
Range on HMM: 33-282/314.0
PPSDLCTVFNHPVNNKKNRYSNIPCLDiSRVQLkfKMPNKNSTDYIHANYIRSPflkRGYILTQGPKKETRADF----------WRMI--WQENTTAIVM
.|.  ..|.....| .|||| .|.. | .||.|  .  . ...|||.|.|....   . .| ||||...|  ||          |||.  .. |.  |||
lpeltilvadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LCQFLETNREKCAEYFPRNAhcclqfdkfSVNYEDSTVnkslvttrlnlsyegeTRLITHWLWKEWPDWQVPeSSEVML
                     |... . . | .|....            .. |... .                .||. ..|.  .||...| ..| ..
srdevladelsrLdaAlgKtpllildgngneptaadlellk.........eelydpelf................erlgikylripvpDgsap.lledfd

KILRKIRA--RSTPPVIHCSAGVGRSGTLMAVEIALQSIhtHFTLPDIKQIVSHLRV-TGRAASVQTLQQYMLIWKVLLDFGVA
..|. |..  . .| ..||.||.||.||.... . .     ...| .. . |   |    .  ....|.||  |...||..   
eflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 278-541 2.2e-35 116.9 In-house 33-297 (312) alignment 
Range on Protein: 278-541
Range on HMM: 33-297/312.0
PSDLCTVFNHpvNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCA
.   || | .   .  ||| || | |  |  |       .   |||||...       .. |||| ..| . ||..     .|.|..|| |.|   ||||
sdsectaflk..fkdlnrypniqcwdrgrftla.....gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekca

EYFPRnAHCCLQFDKFSVNYEDST------VNKSLVTTRL---NLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARSTPPVIHCSAGVGRSG
.|        ....   |  |  |        |  .| |.    .   |.   . |. |  |||  .|.| .  |..|  ..    | . ||||||||.|
kyisd.ivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtg

TLMAVEIALQSIhTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVA---YKQiTEELAEKFNSTYR
||. .|  . ..  |    ..|..   ||   || ||... ||.   ...|.|  .   ||.  |.   ||. || 
tlaliesmiaal.rhprkqnvkdsfvllr.kdrarsvrvfpqyvyalrcvleflyskglykr.neqewtkfketya
subfamily_CG7180_pd Subfamily CG7180 278-524 2.6e-35 116.5 In-house 30-292 (296) alignment 
Range on Protein: 278-524
Range on HMM: 30-292/296.0
PSDLCTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNReKCA
 .. |    .  | .|||. ..   |  || |. |.  ....||| | |. |   |. || |..|||||  .|||....|.. |.|.|..  . .. .. 
eigdCagglrkenreknrdvkvvPyDynRvvLe.kldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

EYFPRNAhcCLQFDKFSVNYEDSTV-----------NKS-LVTTRLNLSYEGETRLITHWLWKEWPD-WQVPESSEVMLKILRKIRA---R------STP
.|.| ..    |. .. |..  .             .|  . .|  .   . |||....  ..||.   .|| |.. .....|..|    .        |
sywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

PVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVA
 |...| |..|||  .|....|. .. .  . |. . |  ||   |   |.. ..|. |. |||.. ..
vvvvssdGasRsGvylaidanlelvekeeev.dvFeavktlrr.sRpqLvenveeYkyiYdvlleavlc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 281-523 6.3e-37 122.1 In-house 26-271 (285) alignment 
Range on Protein: 281-523
Range on HMM: 26-271/285.0
LCTVFNHPVNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFLK-RGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEY
 ||   .  |   |||... |.. .|| ||     .   |||||...| |      || ||||  || .|||.||.||. . ..||| ..|   |||| |
nctytayeanpdlnryadvrcieetrvvlk.....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

FPRNAHCCLQFDKFSVNYEDS-------TVNKSLVTTRLNlSYEGETRLITHWLWKEWPDWQVPESSEVML---KILRKIRARSTPPVIHCSAGVGRSGT
.| .    ..| |. .   .        |. ..|  .  .     |   . |     |||   || .  |.   | ..|.  . .| ..||||||||. |
ypeklgevvkfgkyeitlteckeeaiagtilnaltvinte.dasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtat

LMAVEIALQSIHTHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
.. .. |   |     . .. .||  .|   |  .||.  |..... ||... .
fvgidyatirimenpni.emldivremram.rfqavqshmqflflyvvlmeyfi
0040439 (Phosphotyrosine protein) phosphatases II 282-521 2e-67 222.7 In-house 3-245 (249) alignment 
Range on Protein: 282-521
Range on HMM: 3-245/249.0
CTVFNHPVNNKKNRYSNIPCLDISRVQLKFkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFP
..|...|.| .||||..|...| |||.|.  .|. . .|||.|.||  .  || .|.|||| .|| .|||||.|... |.||||... | .|||||.|.|
ysvallpenkdknrypdilpydhsrvklsi.lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

RnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA------RSTPPVIHCSAGVGRSGTLMAV
      |....|.|.. . .|....... | |.  |.||.| ..|. .  ||| .||.| | .|......|       ...| ..||||||||.||. | 
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

EIALQSIHTHFTlPDIKQIVSHLRVTGrAASVQTLQQYMLIWKVLLDF
 ..|. .... .  |....|..||      .||...||. . ..||..
ylmleqlekelg.vdleeavkllrsqR.pgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 282-520 2.6e-67 222.1 In-house 1-241 (245) alignment 
Range on Protein: 282-520
Range on HMM: 1-241/245.0
CTVFNHPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFP
..|...|.| .|||||.|...| .||.|.  ... . .|||.|.|.  .  ....|.|||| .|| .|||||.|... |.||||... | .|.|||.|.|
ysvallpenkdknrysdilpydhtrvkls.pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

RnaHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVE
   .. |....|.|.. . ......... |...  ...|.| ..|...  ||| .||...| .|..|. .|      ...| ..||||||||.||..|. 
l..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

IALQSIHTHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
..|. ....    .. ..| .||   |  .|||..||. . ..||.
lmleqleke.lgvsleeavkelrsq.Rpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 282-519 9.2e-62 204.1 In-house 2-239 (243) alignment 
Range on Protein: 282-519
Range on HMM: 2-239/243.0
CTVFNHPVNNKKNRYSNIPCLDISRVQLkfkmpnkNSTDYIHANYIRSPflkRGYILTQGPKKETRAD----FWRMIWQENTTAIVMLCQFLETNREKCA
......|.| .|||||.|...| ||| |       ...|||.||.|. .   ...|.|||| .|| .|    ||||.|....|.||||... | .|||||
fsiallpenlsknrysdilpydhsrvkl.......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

EYFPrNAHcclQFDKFSVNYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIR------------ARSTPPVIHCSA
.|.| . .   ....|.|.. .... .. . . | |..   ...|||..|...  ||| .||.| | .|..|...|             .. | ..||||
qywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsa

GVGRSGTLMAVEIALQSIhtHftlPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLL
||||.||| |  . |. .  .    |. ..| .||      .|||..||. . ..||
GvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN1_pd Subfamily PTPN1 282-515 3.9e-52 171.8 In-house 24-264 (290) alignment 
Range on Protein: 282-515
Range on HMM: 24-264/290.0
CTVFNHPVNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFP
... ..| |...||| ..   | ||..|.     ....||| |. .  . .|| |||||||  .| . ||.|.|.... |.||| ...| .. |||.|.|
treaklpenrnlnryrdvspydhsrikle.....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

RNAH-CCLQFD--KFSVNYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTL
.. .  .|...  |..|..    ...  .   |.|      ||| |.|. .  |||. ||||   .|| | |.|          |.|||||||.|||||.
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

MAVEIALQSIHTHFT--LPDIKQIVSHLRVTgRAASVQTLQQYMLIW
. |.  |  |. .      |||. . .||   |   .|| .|  . .
clvdtclvliekkddlssvdikkvllelrky.rlGliqtadqlrfsy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 283-522 1.8e-45 150.6 In-house 18-258 (284) alignment 
Range on Protein: 283-522
Range on HMM: 18-258/284.0
TVFNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCqfletnREKCAEYFPR
|  | . |  |||. .|   | ..|.|.  .  .. .||| | .|     |  || ||||...| ||||||||. |...||.|       ..||..|.| 
tfanldqnkdknrighilafdknvvklerli.GeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

NAHccLQFDKFSVNYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIR------ARSTPPVIHCSAGVGRSGTLMAV
..    . ..| |. .  .  .  |   ..||    | . | |. . .. |||  ||...  ......|.|         .. |.||||||||.|. ...
kiv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

EIALQSIHtHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD---FG
.. |. .. .    |. ..|  ||   |   || | ||..|.  ||.   ||
dvlldrmk.eekqvdvynfvrdlrq.qrntlvqdlvqykfiysalleehlfg
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 284-524 1.5e-49 163.5 In-house 3-244 (250) alignment 
Range on Protein: 284-524
Range on HMM: 3-244/250.0
VFNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREkCAEYFPRN
| ..| |..||||..|  || ||| |. .    . .||| | .. .   .. .| |||| ..|  |||||...|....|||| .. |.... . .|.| .
vakkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

AhcCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGET--RLITHWLWKEWPDWQVPESSEVMLKILRKIRAR-----STPPVIHCSAGVGRSGTLMAVEIA
     .. .  |.  .. .   .....| || . ..  |.. .  .  |||  |||  . .|..|.|..|      ..| ...|||||||||. .|..  
k..aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LQSIHTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVA
|. ...  .. |. ...  ||   |  .|..|.||. .....| . ..
lerlkkekvv.dvfkvikvlrk.drphavesleqyvfvyeiilkalds
subfamily_PTPRN_pd Subfamily PTPRN 285-516 1.5e-36 120.6 In-house 51-286 (297) alignment 
Range on Protein: 285-516
Range on HMM: 51-286/297.0
FNHPVNNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPF-LKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRN
 ... | ||||....   | |||.|| .  .....||| |  |      .  || ||||  .| ||||.|.|.. .. ||.|..  |.. ..|..|.| .
akaeknvkknrskavlpydhsrvklkeea.saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

AHCCLQFDKFSVNYEDSTVNKSLVTTR-LNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKI----RARSTPPVIHCSAGVGRSGTLMAVEIALQ
 .   .. .  .  |    .  || .  |      ||| .| . .  ||. .|| |.  .|.  ||.    | ||.| |.|||.|.||.|. ..... |.
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln

SIHTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWK
 .       ||   . |||   |.  |.| .|. ....
rllkGvkeidiaatlehlr.dqrpglvktkdqfefalt
subfamily_PTPN12_pd Subfamily PTPN12 286-523 5.9e-60 197.6 In-house 36-278 (290) alignment 
Range on Protein: 286-523
Range on HMM: 36-278/290.0
NHPVNNKKNRYSNIPCLDISRVQLKFKMPNKnSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAH
....| ||||| .|   | |||.|. .  ..   ||| ||.|. .  |  || .|||  .|  |||||||. |.. .||.|. .| .. ||. |.| . .
ekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

CCLQFDKFSVNYED-STVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA----RSTPPVIHCSAGVGRSGTLMAVEIALQSI
  |.|..|.|. |.  .|.. ..   |..  ..|.| .. . ...||| .||.| . .|......|      ..| |.|||||||| ||..|.... . .
eelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrell

HTHFT--LPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
... .    |. ..| .|| . ||| ||| .|| |..| ....  
kaekipeeldvfdlvlelr.kqraalvqtkeqyelvykavaelvq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 287-521 2.6e-47 156.0 In-house 30-265 (283) alignment 
Range on Protein: 287-521
Range on HMM: 30-265/283.0
HPVNNKKNRYSNIPCLDISRVQLKFKMPnknstDYIHANYIR---SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRN
   |..|||. .|   |  ||.|| . .     ||| | .|    |   ...|| .|.| ..|. |||.|...|. |||||| .. | .|.||. |.|..
adenkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

AhcCLQFDKFSVNYEDSTVNKSLVTTRLNLSYE---GETRLITHWLWKEWPDWQVPESSEVMLK---IL-RKIRARSTPPVIHCSAGVGRSGTLMAVEIA
     .. .| |  .. | ..|..   | | ..    .| |..|.   .| ...     . ..|   .   . . . .| |.|||.|.||.....|.  .
G..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasas

LQSIHTHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
.. . |. .. |. ..|  .|.  |   ||||.||.|. .. |. 
vkdalte.svvdvfavvkimreq.rmmavqtldqyklvhelvleq
subfamily_ptpA1_pd Subfamily ptpA1 287-488 1.8e-35 117.5 In-house 44-264 (418) alignment 
Range on Protein: 287-488
Range on HMM: 44-264/418.0
HPVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRgYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHC
.  |  ||||.||  .. .||||| |. .|. .||| ||||   . |. .| ||||  .| ||||||.|..    |||| .  |  | ||  |.| .   
kkhntsknrytnilpvnhtrvqlk.kiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigg

---------CLQFDKFSVNYEDST--VNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR----------STPPVIHCSAGVG
            |  .||.  .     .. ..|  . |..||||| ||.. .. ||| ..|. .. . ..|. |  |            | ..|||||||
eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RSGTLMAVEIALQSIHTHFTLPD
|.||. .  | .. .  .|   |
rtgtfctavimmkkldhyfkqld
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 288-519 3.3e-37 122.9 In-house 5-237 (239) alignment 
Range on Protein: 288-519
Range on HMM: 5-237/239.0
PVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHc
 ||. ||||.||   | ||| |. |. |   .||| |.|.|      . || |||  . .  |||||.|||    ||||  ..|  ..|| .|.| ..  
rvnkaknryanivtydhsrvvle.klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

clQFDKFSVNYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARST----PPVIHCSAGVGRSGTLMAVEIALQSI
  .. .. |    . |    .   . .|   . | | . .. .  |||  ||. .  .| . |||   |     | ||||||||||.|... ..  |.  
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

HTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLL
. . |. || . |  .|   |   ||| .||..|   .|
kkqktv.difnyvkaire.drphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 288-519 3.7e-37 122.8 In-house 6-238 (239) alignment 
Range on Protein: 288-519
Range on HMM: 6-238/239.0
PVNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHc
 ||. ||||.||   | ||| |. |. |   .||| |.|.|      . || |||  . .  |||||.|||    ||||  ..|  ..|| .|.| ..  
rvnkaknryanivtydhsrvvle.klsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

clQFDKFSVNYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARST----PPVIHCSAGVGRSGTLMAVEIALQSI
  .. .. |    . |    .   . .|   . | | . .. .  |||  ||. .  .| . |||   |     | ||||||||||.|... ..  |.  
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

HTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLL
. . |. || . |  .|   |   ||| .||..|   .|
kkqktv.difnyvkaire.drphmvqtseqyvfihlavl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 289-521 1.7e-53 176.3 In-house 19-263 (270) alignment 
Range on Protein: 289-521
Range on HMM: 19-263/270.0
VNNKKNRYSNIPCLDISRVQLKfKMPNKNSTDYIHANYIR-SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHC-
 ..| ||| .|     .||.|. .. ... | || |||.|     |. || ..||.. |  .||||||.|..|||||. .. | .|.||. |.| ...  
rgkklnRyadiLPsPatRvrle.eleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

-CLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPESSE------VMLKILRKIR------ARSTPPVIHCSAGVGRSGTLMAV
  |.. | .|  . .. ..  ..|||.| ..||.| ..|. ...|||  ||....       .||.||..|      ....| ..||||||||.|||.|.
vkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

EIALQSIHTHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
.||.. ....  . |. .|...||   | | ||. .|| ...|... .
DiavrlLeetkkv.dvlaiieelR.kdRmalvqhpeqyeflykavvey
subfamily_PTPN23_pd Subfamily PTPN23 289-519 3.5e-45 149.0 In-house 42-277 (288) alignment 
Range on Protein: 289-519
Range on HMM: 42-277/288.0
VNNKKNRYSNIPCLDISRVQLKfkmpnKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCC
.. .|||. .|   | .||.|.     ..  ||| | ....       .| ||.|...| .|||.|.... .  |||| .  |....|...|.| .    
lyseknrsrdilPyDhnRvklr.....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkget

LQFDKFSVNYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPESSEVMLKILRKIRA--------RSTPPVIHCSAGVGRSGTLMAVEIAL
 .|...||  .. .  .  |   |.|. ..  ... ..|  ...||.  ||.| |..|..| ....          || |.||||||||.|..  |  |.
vkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

QSIHTHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLL
. ....  |.|| |.||.||   |  .||. .|.   ... |
relekgnglldiiqvvsrlreq.Rrfmvqekeqlkfsyeavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 289-524 7.3e-25 82.5 In-house 32-259 (267) alignment 
Range on Protein: 289-524
Range on HMM: 32-259/267.0
VNNKKNRYSNIPCLDISRVQLKFKMPNknstdYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNrekCAEYFPRNAHCCL
 |...||. .    | .|| |. |  .     || | |. .   |. .|.||.| | | .||. .| ... . ||.| .  . |      ..| .   . 
knqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqak

QFDKFSVNYE--DSTVNKSLVTTRLNLSYEGeTRLITHWLWKEWpdwQVPESSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMAVEIALQSI
... ..|..       .  ..|  |..  |  .. .| . .|.|   ..    .  || |  | |.      . | |..||.|||||||.. ..  |. .
kyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

HTHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFgvA
 |  .. || . . ..|   | . |.|...|. | ..| ..  |
ktegvs.difdflrkirs.qriglvdtkeryiyihellaey..a
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 289-395 1.8e-07 22.9 In-house 28-121 (275) alignment 
Range on Protein: 289-395
Range on HMM: 28-121/275.0
VNNKKNRYSNIPCLDISrvqlkfkMPNKNSTDYIHANYIRSPFlkRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQfletNREKCAEYFPRNAHCCL
 | .|||..|. |.|         .  .|   ..||| .|.|.    ....| |.  | ||. ...|  |  ..| |        |    . |..     
rngeknrftnvtcfdei.......ldrenqeffvhantfrtpy..gnflisqapndstnadhlhllwiynvqtvvclvl....peeaggyfvpkegetft

QFDKFSV
 |.|. .
sfqkyqi
Y_phosphatase Protein-tyrosine phosphatase 290-519 2.4e-73 241.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 290-519
Range on HMM: 1-234/235.0
NNKKNRYSNIPCLDISRVQLkfkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQ
| |||||..|.. | .||.|     .....|||.|||...   |. .|.|||| |.| .|||||.|||....||||..  | .|||||.|.|.. .  |.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FDKFSVNYE-DST-VNKSLVTTRLNLSYEGET---RLITHWLWKEWPDWQVPESSEVMLKILRKIRARS----TPPVIHCSAGVGRSGTLMAVEIALQSI
.....|... ...  .|. ... |.|. ..|    | .... ...|||..||||.. .|...||.. ..    .| |.||||||||.||..|..|.|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

HTHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
... . .|..|||..|| . |. .||.|.||. . |..|
eaeee.vdvlqivkelR.kqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 290-519 2.4e-73 241.8 In-house 1-234 (235) alignment 
Range on Protein: 290-519
Range on HMM: 1-234/235.0
NNKKNRYSNIPCLDISRVQLkfkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQ
| |||||..|.. | .||.|     .....|||.|||...   |. .|.|||| |.| .|||||.|||....||||..  | .|||||.|.|.. .  |.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FDKFSVNYE-DST-VNKSLVTTRLNLSYEGET---RLITHWLWKEWPDWQVPESSEVMLKILRKIRARS----TPPVIHCSAGVGRSGTLMAVEIALQSI
.....|... ...  .|. ... |.|. ..|    | .... ...|||..||||.. .|...||.. ..    .| |.||||||||.||..|..|.|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

HTHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
... . .|..|||..|| . |. .||.|.||. . |..|
eaeee.vdvlqivkelR.kqRpgmvqsleqYiflykail
subfamily_egg_pd Subfamily egg 290-522 1.8e-43 143.4 In-house 40-270 (307) alignment 
Range on Protein: 290-522
Range on HMM: 40-270/307.0
NNKKNRYSNIPCLDISRVQLKFKMpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETnrEKCAEYFPRNAHCCLQ
| .| |   ..| | |||.|...   . . |.||||...   |   .||.| | |.|  |||||..||.   ||||    |.  |.|  |.|.     |.
nlekarskrvhckdssrvklelrr.GqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

FDKFSVNYEDSTVN----KSLVTTRLNL-SYEGETRLITHWLWkewpDWQVPESSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSI-HTH
.   |.. |   |.      .  |.|.|   . | | . || .    |..        |..|||.|  |.| |...  || ...||.|.|||| |.    
tvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGp

FTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
 |   ... |  ||   |  ||..  .|.......| | 
itkslvlravvflrlr.rrlsvesvllylfvyrlvlfff
0041856 (Phosphotyrosine protein) phosphatases II 290-520 3.7e-43 142.6 In-house 1-169 (182) alignment 
Range on Protein: 290-520
Range on HMM: 1-169/182.0
NNKKNRYSNIPCLDISRvqlkfkmpnknSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCqfletnrekCAEYFPrnahcclq
| .|||||.|.. | ||             |||.||......  . .|.|||| ..| |||.||..... |.||.|.         .  |.|        
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp........

fdkfsvnyedstvnkslvttrlnlsyEGETRLITHWLWKEWPDWQVPEsSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSihtHFTLPDI
                          | ..||....|.  |||. ||.  . .|.......... | ..||||||||.||| |  . ..    ...|...
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...gvsleea

KQIVSHLRvtgrAASVQTLQQYMLIWKVLLD
 . |   |      .|.|..|| ..  .||.
vklvrsrR....pgmvitpnqyfflqlalle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 290-530 5.4e-38 125.4 In-house 50-284 (301) alignment 
Range on Protein: 290-530
Range on HMM: 50-284/301.0
NNKKNRYSNIPCLDISRVQLkfkMPNKNsTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQ
...|.|| ..||   . |..   . . .    ||||.| ..   . .| |||| |.|. ||| |. | .   ||||.|..| . |||.||.| . .  |.
pkdkhryptvPckPstavev...ivdGk.rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

FDKFSVNYE--DSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHF
 ..|... .  .. .||...  .|..     . .|| .||. ..||.| .||.|   . ...  ..    | |.|||||.||| .... |.  . .... 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadp

TLpDIKQIVSHLRvTGRAASVQTLQQymLIWkvlLDFGVAYKQITE
|. .... . |||   |  .||| .|  | |   . .|  |. | |
ti.eltealkhlr.ehrwngvqtnsq..lyw...mtlGtvyrlike
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 290-519 1.5e-37 124.1 In-house 3-236 (237) alignment 
Range on Protein: 290-519
Range on HMM: 3-236/237.0
NNKKNRYSNIPCLDISRVQLKFKMPNknsTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCcL
|. ||||.|| . | ||| ||    .   .||| |.|...     . || .||| . .  |||.|.|||. . ||||  ..| |..|| .|.|       
nkiknrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp.a

QFDKFSV------NYEDSTVNKSLVTTRLNLSyegETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMAVEIA
 . ...|      .. | ||   |...||.|    | |||  . .  |||  ||. .  .|.. ..|  |      |.| .|||||||||.| .. ..  
aygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

LQSIHTHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
|.  . .  . || . |  .    |   .|| .||..| ...|
lrqakek.kvvdiynyvysie.edrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 290-440 5.4e-29 96.0 In-house 33-184 (297) alignment 
Range on Protein: 290-440
Range on HMM: 33-184/297.0
NNKKNRYSNIPCLDISRVQLKFKMPNKnstDYIHANYIRSPFLKR--GYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCC
  .|||| .|   | .||.|.  ....   ||| |.|.  |  .    |||.||| ..|  |||.......  .|||.... |  |.||| |.|.     
slrknryrdilatddtrvkllrviter...dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

LQFDKFSVNYEDSTV---NKSLVtTRLNLSYEGETRLITHWLWKEWPDWQVPESSE
|.  .. |..  ||    ..  . | |.| |  |.| ..|  .  |||  ||   |
lkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdle
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 290-375 4.5e-06 20.4 In-house 34-117 (332) alignment 
Range on Protein: 290-375
Range on HMM: 34-117/332.0
NNKKNRYSNIPCLDISRVQLkfkMPNKNSTDYIHANYIRSPFLKRGYILTQGPKK-ETRADFWRMIWQENTTAIVMLCQFLETNREK
|   ||   . |.| |||.|    |.    |.  |...     |  ||..| | .  |   ||||. . . . |... .  | .. |
nmdmnriphlycfdhsrvel...apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 292-383 1.3e-17 58.6 In-house 49-153 (350) alignment 
Range on Protein: 292-383
Range on HMM: 49-153/350.0
KKNRYSNIPCLDISRVQLK--FKMP-----NKNSTDYIHANYIRSP----FLKRG--YILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAE
 ||||.||   . |||.||   | .       .. ||| |||.. .      . .  || ||.| ..|  ||...| . . . |..| .  | |.||| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YFPRN
|... 
YWqeg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 292-382 1.9e-08 28.1 In-house 50-155 (349) alignment 
Range on Protein: 292-382
Range on HMM: 50-155/349.0
KKNRYSNIPCLDISRVQLKFKMPN----KNS---------TDYIHANYIRSPFLK--RGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKC
 ||||..|   . |||.||  . .    |.|          ||| |||.. . ..  . || || |   |  ||...|  ..   .. | .  |.. |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

AEYFPR
  |.  
diywqe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 293-540 2.8e-39 130.0 In-house 22-279 (290) alignment 
Range on Protein: 293-540
Range on HMM: 22-279/290.0
KNRySNIPCLDISRVQLKfKMPNKNSTDYIHANYIRSPFLKRgYILTQGPKKET-------RADFWRMIWQENTTAIVMLCQFLETNRE----KCAEYFP
..|  ..| .  .|| ||    .. . ||||||..  |   |  |||| |....         .|| |. ||. . .||||.| | ...     ||.|.|
dqR.levpLveatrvvLk.gygkrfnddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp

RNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRL-ITHWLWKEWPDWQVPESSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSI
 ..   |.|. ..|.  .   .. . | .| . ...|  . .|| | |.| . .|.|.. ..|....|..|. || ..||  |. || .| |.... | |
esvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQki

HTHFTLPDIKQIVSHLRVTgRAASVQTLQQYML-IWKVLLDFGVAYKQITEELAE-KFNSTY
        ...... ||   ||  ... ...   .  ..| .  ...|..||  | | .. .
aetsgsvkledvlkalrkq.ralaitsalelafvdagivllaievldqfaeeetekkakaee
subfamily_eak_pd Subfamily eak 296-442 4.5e-16 53.1 In-house 58-201 (332) alignment 
Range on Protein: 296-442
Range on HMM: 58-201/332.0
YSNIPcLDISRVQLKFKMpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSV
.  .|  |   |.|   .  .|   || |  .  . . | ||||  ....    ||.|. .... |||.| . .| . ||   ||| ...  |.| .. |
vkivp.ydrylvrltssq..lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv

NYEDStVNKSLV-TTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVM
.  .  |... . |  | ||   ||  . |.    | . ..|   . .
erkef.vkrniletrllelskGnethrvlhykvfGwtettlpkyedfl
0044763 (Phosphotyrosine protein) phosphatases II 310-514 1.6e-27 91.7 In-house 9-163 (178) alignment 
Range on Protein: 310-514
Range on HMM: 9-163/178.0
KFKMPNKNSTDYIHANYIRsPFlkrgYILTQGPKketrADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHcclqfdkfsvnyedstvnkslvtt
 ..... ...|||.|..|  |.    ..|.. |     ||......... |.||.|.. || ...|| .|.|..|.                        
lsnleglersdyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag........................

rlnlsyegetrliTHWLWKEWPDWQVPESSEVMLKILRKIR----ARSTPPVIHCSAGVGRSGTLMAVEIALQSihtHFTLPDIKQIVSHLRvtgrAaSV
              ..|.  .||. ||...| .|.... |.     .  | ..||||||||||||.|  . ..    ...|... . |   |       |
.............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl...glsleeaielvrerR....p.iv

QTLQQYMLI
..  |.  .
pnpgqlrqL
0046846 (Phosphotyrosine protein) phosphatases II 316-517 2.9e-34 113.7 In-house 9-168 (176) alignment 
Range on Protein: 316-517
Range on HMM: 9-168/176.0
KNSTDYIHANYIRSPFlkrgYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLqfdkfsvnyedstvnkslvttrlnlsy
 .. |||.||.| ...    .| ||||  .| |||..|..... ||.|.|..  |..| ||. |.|.     .                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

egetrlitHWLWKEWPDWQVPESsEVMLKILRKIRARS---TPPVIHCSAGVGRSGTLMAVEIALQSihthfTLPDIKQIVSHLRVTGRAASVQTLQQYM
        ..|.  ||| .||.. | .|..|. || .     | ..|||||.||.||| |  .   .        .. ......|   .  .||| .|| 
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQyr

LIWKV
 . ..
flyef
0043147 (Phosphotyrosine protein) phosphatases II 317-515 1.5e-36 121.1 In-house 3-154 (172) alignment 
Range on Protein: 317-515
Range on HMM: 3-154/172.0
NSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFletnrekcaeyfprnahcclqfdkfsvnyedstvnkslvttrlNLSYE
...|||.|.|.  ..  . .| ||||  .| ||||||..... |.||.|...                                            . .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GETRLITHWLWKEWPDWQVPeSSEVMLKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALqsihTHFTLPDIKQIVSHLRvtgrAASVQTLQQY
...||. ..|.  |||  || ..|..|..|. |.      .. | ..||||||||.||| |  . |     ...| .. . | . |      .||. .||
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lglsleeavalvrekR....pgavqnpsqy

MLIW
... 
rfly
0051429 (Phosphotyrosine protein) phosphatases II 318-533 1.5e-37 125.1 In-house 3-236 (272) alignment 
Range on Protein: 318-533
Range on HMM: 3-236/272.0
STDYIHANYIRSPFL---KRGYILTQGPKKETRADFWRMiWQENTTAIVMLCQFLETNREKCAEYFP----------RNAHCCLQFDKFSVNYEDSTVNK
 ..||.|...  ..    .. .....|| . | |||||. .... ..||.|..  | .|.||  | |           ...    . ...| .   ..  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

SLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPESSevMLKILRKIRArSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPD-------IKQIVS
  . ..| |.   . ||.| ..|...  |||  ||...  .|..|. ... . | ..|||||..|.||. |. . |. .. .  . |       . ..|.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

HLRVTGrAASVQTLQQYMLIWKVLLDFGVAYKQITEELA
.||    ...||| .||. ....||..  .. .. .|  
elraqr.pgavqteeqylflyeallellrsllsvraeyl
0036282 (Phosphotyrosine protein) phosphatases II 319-515 1.8e-36 120.8 In-house 2-163 (174) alignment 
Range on Protein: 319-515
Range on HMM: 2-163/174.0
TDYIHANYIRSPFLKRGYILTQGPKKetradFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRnahcclqfdkfsvnyedstvnkslvttrlnlSYEGE
.|||.|...      ...|..||| .     ||.|..... |..|||..  | ...||  |.|.                                .| .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TRLITHWLWKEWPDWQVPESSEvMLKILRKIRAR-----STPPVIHCSAGVGRSGTLMAVEIALQSIHthFTLPDIKQIVSHLRVTgRAASVQTLQQYML
.||. ..|.  ||| .||..|. .|.... ..       . | ..||||||||.|||.|  . |. ..   .| |. ..|  ||   |  .||| .||. 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlq.rpgmvqtpsQyrf

IW
. 
ly
0051082 (Phosphotyrosine protein) phosphatases II 319-518 1.6e-29 97.8 In-house 3-149 (151) alignment 
Range on Protein: 319-518
Range on HMM: 3-149/151.0
TDYIHANYIRSPflkrgYILTQGPkketRADFWRMIWQENTTAIVMLCQFLETNreKCAEYFPRNAhcclqfdkfsvnyedstvnkslvttrlnlsyege
.|||...|. .      .....||     |||........ ..||.|..  |..  .|.||.|..                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

tRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR-STPPVIHCSAGVGRSGTLMAVEIALQSihthftlPDIKQIVSHLRVTGRaASVQTLQQYMLIWKV
 . ..|. .  ||| ..|.| . .|..|.....  . | ..|||||.||.|||.|. . |.         .. ......| .    .||. ||.... ..
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrp.gvvqpnqqflfqlfa

L
|
l
0049260 (Phosphotyrosine protein) phosphatases II 333-515 3.9e-31 103.2 In-house 8-143 (152) alignment 
Range on Protein: 333-515
Range on HMM: 8-143/152.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFprnahcclqfdkfsvnyedstvnkslvttrlnlsyegetrlitHWLWKEWPD
.. .| ||||  .| ||||||... . |.||||...|| ...||..|.                                           ..|.  |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpD

WQVPESSEVMLKILRKI----RARSTPPVIHCSAGVGRSGTLMAVEIALqsihTHFTLPDIKQIVSHLRvtgrAASVQTLQQYMLIW
  ||..|...| .|. |    . .. | ..||||||||.|||.|  . |     ...| .. . |   |      .|.. .|.... 
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml....lgvsleeavalvrekR....pgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 333-517 1.2e-15 52.2 In-house 3-198 (198) alignment 
Range on Protein: 333-517
Range on HMM: 3-198/198.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLeTNRE-KCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS----YEGETRLITHWLW
.| || || | .|| ||||.|.|.  .  |||. .    |.|   . |.|     . ..  .||  .  |..   . | | |.        || |.|. .
qrryiatqhplretladfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KEWPDWQVPESSEVML------KILRKIR-ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHT-HFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKV
  | .   |. .  .       .. .|    . .| ..||| | | .| ..|..| ..|    . .. |. ..   ||   |   . .||.| .|..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrq.arcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 333-517 1.3e-15 52.1 In-house 4-199 (199) alignment 
Range on Protein: 333-517
Range on HMM: 4-199/199.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFLeTNRE-KCAEYFPRNAHCCLQFDKFSVNYEDSTVNKSLVTTRLNLS----YEGETRLITHWLW
.| || || | .|| ||||.|.|.  .  |||. .    |.|   . |.|     . ..  .||  .  |..   . | | |.        || |.|. .
qrryiatqhplretmadfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KEWPDWQVPESSEVML------KILRKIR-ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHT-HFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKV
  | .   |. .  .       .. .|    . .| ..||| | | .| ..|..| ..|    . .. |. ..   ||   |   . .||.| .|..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrq.arcgiisslqhynfiyqv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 333-434 1.6e-10 34.9 In-house 235-332 (440) alignment 
Range on Protein: 333-434
Range on HMM: 235-332/440.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFletNREKCAEYFPRNAHCcLQFDKFSVNYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPD
|  .| || |   |  ||||.. . . ..|.|| |.   |   |. |.| |.   . |  |.| .  |   . .    |.| |  |   |  .  . || 
knafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwpt

WQ
| 
wi
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 335-527 9e-29 95.3 In-house 36-226 (255) alignment 
Range on Protein: 335-527
Range on HMM: 36-226/255.0
GYILtqgpkkeTRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDsTVNKSLVTTRLNLSYEG---ETRLITHWLWKEWP
 |.|       | . |...| | .|. .|||| | | ..||| .||| .    |.. . .|   . .... .. |.  .|. |   .|. ..|. .| |.
lysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWi

DWQVPESSEVMLKILRKIRArSTPPVIHCSAGVGRSGTLMAVEIALQ----SIHTHFTLP-DIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYK
. . || .. .|.||. .|  | . |.|||.|.||| ... .|.. |    |..|  |   | .... .|| . |.....|  |  .   ..||.    .
eknaPelareilnilkvvrd.sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrsk.rkraihtPlqlafsilmvldlvfpkg

Q
.
e
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 341-514 2.4e-24 80.3 In-house 98-280 (302) alignment 
Range on Protein: 341-514
Range on HMM: 98-280/302.0
GPKKETRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYE-------DSTVNKSLVTTRLNLSYE----GETRLITHWLWKE
 |||.|.  .| .| | |.. .| ||.| | . .|||||.  .    |.| ...|.         . |  ||..   ...  |       . .   ..  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDWQVPESSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLI
|||   |. ..  |.||.   .  .  ..||||||||.|||.|.   .|   ..    |. .||  .|   |  .||. || . .
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskk.kvtdllsivlpvrq.cryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 346-522 3.4e-24 80.1 In-house 46-227 (263) alignment 
Range on Protein: 346-522
Range on HMM: 46-227/263.0
TRADFWRMIWQENTTAIVMLCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYEDSTVnKSLVTTRLNLSYEG---ETRLITHWLWKEWPDWQVPESSEVM
| . |...| | .|. .|||| | | ..||| .||| .    ... . .|   ..   . |. |.  ||. |   .|. ..|. .| |.. . || .. .
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LKILRKIRaRSTPPVIHCSAGVGRSGTLMAVEIALQ----SIHTHFTLP-DIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
|.||.  |  | . |.|||.|.|||     .|.. |    |..|  |   |  ... .|| . |.....|  |      ..||| 
lnilkvar.nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrss.rkraihtPmqLafsilmvLdfv
0048179 (Phosphotyrosine protein) phosphatases II 407-514 5.3e-17 57.3 In-house 34-137 (144) alignment 
Range on Protein: 407-514
Range on HMM: 34-137/144.0
VTTRLNLSYEGETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR---STPPVIHCSAGVGRSGTLMAVEIALqsiHTHFTLPDIKQIVshlRVtGRAA
.. . .  .| ..| ....|.  |||..||...| .|..|. |..    . | ..||||||||.|||.|  . .   . ...| .. . |   |   |  
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klglsleealalv...rs.rrpg

SVQTLQQYMLI
.|.. .|.. .
avpnpgqlrfL
0048076 (Phosphotyrosine protein) phosphatases II 408-517 1.7e-17 58.9 In-house 31-138 (145) alignment 
Range on Protein: 408-517
Range on HMM: 31-138/145.0
TTRLNLSYE--GETRLITHWLWKEWPDWQVPESSEVMLKILRKIRAR---STPPVIHCSAGVGRSGTLMAVEIALQsihTHFTLPDIKQIVSHLRvtgrA
|| |||..|  ...||....|.  |||..||...| .|..|. |..      | ..||||||||.|||.|  . |.    ...|... . |   |     
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll...lgvsleealelvrsqr....p

ASVQTLQQYMLIWKV
 .|.. .|.  . ..
gavpnpgqlrflyef
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 412-520 8.8e-10 32.5 In-house 79-192 (440) alignment 
Range on Protein: 412-520
Range on HMM: 79-192/440.0
NLSYEG--ETRLITHWLWKEWPDWQVPESSEVMLKILRKI-----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLpDIKQIVSHLRVtGRAAS
| ||    |.| . .. .. |||  ||. .  .||... .     .| . | ..|||||.||.| ..||.  |.  .    . ||  ... .|   |   
nasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrn.nrpqm

VQTLQQYMLIWKVLLD
||| .|| .. ...|.
vqtpeqyafvheavle
PTPc_DSPc_SM00012 422-519 1.7e-24 81.4 In-house 2-104 (105) alignment 
Range on Protein: 422-519
Range on HMM: 2-104/105.0
ITHWLWKEWPDWQVPESSEVMLKILRKIRARST------PPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIW
..|  ...||| .|||.|. .|..||...   .      | |.||||||||.||..|..|.||..... . .||.|||..|| . |. .|||..||. . 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr.kqRpgmvqteeqylfly

KVLL
..||
rall
0038934 (Phosphotyrosine protein) phosphatases II 423-473 9.6e-06 20.9 In-house 80-135 (194) alignment 
Range on Protein: 423-473
Range on HMM: 80-135/194.0
THWLWKEWPDWQVPESSEVMLKILRKIR-----ARSTPPVIHCSAGVGRSGTLMAV
 ..|   .||  .. | |..|..|. .        .   ..|| ||.||.||| | 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 444-519 5e-14 46.8 In-house 219-292 (297) alignment 
Range on Protein: 444-519
Range on HMM: 219-292/297.0
KILRKIRARSTPPVIHCSAGVGRSGTLMAVEIaLQSIHTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
. ||    |... ..|||||||||| ..  .. . ..  .  .||.. |.|.||   ||  ||||.|. |.... |
eslraemprnayllvhcsaGvGrsGvvvlsdv.ilaklrkkripdvaailsilr.eqrarlvqtleqfellydavl
subfamily_CG42327_pd Subfamily CG42327 451-522 2.8e-15 50.8 In-house 245-315 (319) alignment 
Range on Protein: 451-522
Range on HMM: 245-315/319.0
ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHTHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFG
 .  | |.||| ||||.|...| .||..|. .     || |.||..|  .|| .|.| .|| .|.|||  . 
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvr.rdrasavltkeqyefiykvlseya
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 451-521 3.3e-08 27.7 In-house 260-343 (350) alignment 
Range on Protein: 451-521
Range on HMM: 260-343/350.0
ARSTPPVIHCSAGVGRSGTLMAVEIALQ------SIHTHFT--------LPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||.| ..|||||||| |||....  |.       .  ...           |..|| .||   |   ||.|.|.. |.. || .
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelr.kqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 457-518 8.1e-06 20.1 In-house 1-60 (69) alignment 
Range on Protein: 457-518
Range on HMM: 1-60/69.0
VIHCSAGVGRSGTLMAVEIALQSIHTHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVL
|.|||.| ||.||..|. . .  | .   | ||   | ..|   |   |    .||.|   |
vvhcssGtGrtGtfiaimvemarikse.klvdifnnvqymrk.crpmmvmneneymfihdal