Gene M05B5.1 in Caenorhabditis elegans

Synonym: CELE_M05B5.1, M05B5.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf17
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP126_AA protein Get Run
CeleP126_AA_79-412 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 78-196 8.1e-16 53.0 In-house 8-121 (305) alignment 
Range on Protein: 78-196
Range on HMM: 8-121/305.0
GLCKYILDMKEASLNTY-FDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmgpaddVEGYINASHIRFDNASTDYILTQYPLPST
 | .|| ...  | ...  . ..    ....  .. |.|..|||.|.. | |  |. ||. |. .       . |||||..   . .  ||..| ||..|
dlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld......dsdyinasyvdgykrkkkyivaqgPlknt

IRDFWKMVYVTKVTQVITIF
..|||.... .||.... . 
vadfWrliveekvstivmlt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 79-420 2.9e-221 728.0 In-house 1-347 (347) alignment 
Range on Protein: 79-420
Range on HMM: 1-347/347.0
LCKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTnPEKSKMGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIR
.|||.||.|||||.||||.|||||||||.|..||||...|||.|||||||||||||. |||||...|||||.|||||||.|||||..|||||||||.|.|
fckylldikeaslstyfdenlanyspskftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvr

DFWKMVYVTKVTQVITIFEPIKDEAIEEFANfpAPASPVPPPPTASSKDIGSSP---DQQPREREQIEIKSIRCDNHLHQ-SFFPLSTDHYLNLEGWLIN
||||||.|||||||.||||||||||||||||  |..|.|.|.||||||||||||   ||..|||||||||||||...||. |||||.|||||||.|||||
dfwkmvsvtkvtqvvtifepikdeaieefan..atlslvapaptasskdigsspvpidqiarereqieiksircesnlhrssffpletdhylnlkgwlin

TRAVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPT----VGKQPPVIVMCDLGLDRSATVVLTSIIIEQ
|||||||||.|||||||||||||.|||||||||||||||||||.||||.|||||||||||||||..    ..|..||.||||||||||||||||||||||
travevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieq

VLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLNE
|||||||||||||.|||||||||||||||.||||||||||||||||.|||
vldgktpdcddlfkkmrdqragvftmsifytyairaalfylklklqtlne
0036941 (Phosphotyrosine protein) phosphatases II 80-419 5.1e-58 192.1 In-house 4-285 (297) alignment 
Range on Protein: 80-419
Range on HMM: 4-285/297.0
CKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRD
....  .  | | ..|.  | .. . ...  ....|..||| ||.   | |||.|           |.  .|||||.. . . .  .|.||.|||.|. |
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..........ddegsdYinAsyvdgydlkrkfIatqgPlpntved

FWKMVYVTKVTQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLSTDHYLNLEGWLINTRAVE
||.||.  .|| .... |.. .. .                                                  ....|| ....|. ... .... ||
FWrmvweqnvtvIvmltelvelgrek................................................caqywpleegesltygdftvtllsve

VDqrCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVL---DGKT
|.   ....  .|.||.  |..|  . ... .|.||. . |.... .|..... |..  .   ...||.|.|  |. ||.|...  ....|.      ..
vv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel.vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkegg

PDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLN
.|  ....|.|.||.|....  .. . ..| |..|| ||....
vdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_PTPN9_pd Subfamily PTPN9 80-194 1.3e-15 52.2 In-house 7-115 (297) alignment 
Range on Protein: 80-194
Range on HMM: 7-115/297.0
CKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRD
 .|. ....  |   . .  ..    . .  .   |..||| .||  .| |||||.. ..      |.   ||||...   .    .| || ||. |..|
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvde......deasdyinanfvdGykqkkafiatqGplkktvsd

FWKMVYVTKVTQVIT
||.||.  .|  .. 
fWrmvWeqevlvivm
0040438 (Phosphotyrosine protein) phosphatases II 81-419 4.7e-56 185.7 In-house 7-284 (317) alignment 
Range on Protein: 81-419
Range on HMM: 7-284/317.0
KYILDMKEASLnTYFD---ANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTI
...||..  .  |..     .| ..... ... |...| .||| .|. . |..||.|.....      |   .|||||.. . | .. .|.||.|||.|.
lalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg......dldsdYInAsyvdgpnlkrkfIatqgPlpntv

RDFWKMVYVTKVTQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRA
 |||.||.  .|| .... |.  .. .                                                  . ..||  ...|. ... .... 
edFwrmvweqgvtvivmLteleelgrek................................................caqYwpl..getltygdftvtlls

VEVdqrcKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTP
.|.    .. .. .|.||. .|.||  . ... .|.||  . |.. . .|....|  .  .   ... ||.|.|  |..|..|...  ...||.  ....
eee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

DCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLN
| .. ....| ||.|....  .. . ..|.|.||| ||.. .
dveeavkelreqRpgavqtpeqyrflydalleylkrkltlep
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 81-203 7.5e-14 46.4 In-house 8-121 (307) alignment 
Range on Protein: 81-203
Range on HMM: 8-121/307.0
KYILDMKEASLNTYFDaNLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPekskmGPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDF
.  ||.   .|   |  .||...|   | . .. | .||| .||| .| .|.|.. .     | | |   || | ..        .| .| || .|. .|
qrtldkgvqalvdefr.vlakktpegvtveafsantdknryqdvkcqdkgrivvkfd.....glasd...yihanylgiaikpkkficaqgplentqysf

WKMVYVTKVTQVITIFEPIKDEA
| |.   ||  || . . |.   
wamaiqekvesvimlckvielak
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 83-207 7.9e-12 39.2 In-house 20-137 (302) alignment 
Range on Protein: 83-207
Range on HMM: 20-137/302.0
ILDMKEASLNTYFdANLANY--SPSKCtfNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpaddvEGYINASHIRFDNASTDYILTQYPLPSTI---
.  ...|.... |  ....   .  ||  . . ||..||...||...|...| |.. .          . |.|||..   . .   ||.| |  ..    
vksldtaevkkef.kkidtmkvdlekC..kafkknlkknqsedvpildsnlvkleaep..........dsyvnaskvevPeltrsiilaQlpkvdsedsv

RDFWKMVYVTKVTQVITIFEPIKD-EAIEEF
 .||.||.  |...|  .  . .  ....|.
eeFWrmvfqekivsvvilvgeeelkktlsel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 86-195 4.1e-17 57.1 In-house 6-106 (285) alignment 
Range on Protein: 86-195
Range on HMM: 6-106/285.0
MKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDdvegYINASHIRFDN-ASTDYILTQYPLPSTIRDFWKMV
||  ...  .. ..  | | .||.  .| | . ||  ||. |. ||||| | ..      |    || || .|.     . || || ||| |. |||.|.
mkcqaisklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdr......d....yihaswmrmpgkdqstyittqgplpetlsdfwhmi

YVTKVTQVITI
|  |.. |. .
yqekiayvlml
subfamily_PTPN14_pd Subfamily PTPN14 88-207 1.2e-15 52.4 In-house 22-136 (300) alignment 
Range on Protein: 88-207
Range on HMM: 22-136/300.0
EASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpEKskmgpaDDVEGYINASHIRFDNAS--TDYILTQYPLPSTIRDFWKMVY
|. . | ..    .   ....  . ..|..|||.|||   . .|| |.   |      .. .||||||.|.   ..   .|| .| ||. |..|||.||.
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsp.tk......enstgyinassikvsvggkersyivaqgPleltvqdfWqmvW

VTKVTQVITIFEPIKDEAIEEF
 ..|. .. . | ..|     |
eqgvqlivmlteeeedgkeksf
0050432 (Phosphotyrosine protein) phosphatases II 89-418 1.6e-54 180.7 In-house 42-306 (308) alignment 
Range on Protein: 89-418
Range on HMM: 42-306/308.0
ASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpaDDVEGYINASHIRFD--NASTDYILTQYPLPSTIRDFWKMVYV
  |...| . |... . .... ....|..||| ||.   | .||.|           |.  .|||||....   . .  .|.||.|||.|. |||.||. 
glleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...........degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

TKVTQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLSTD-HYLNLEGWLINTRAVEVdqrcK
 .|. .... ... .. .                                                    ..||... ..|. ... .... .||    .
qnvrvIvmLtklvengrek................................................caqYwplelgggsleygkftvtllseev....l

NWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
... ..|.|..  |..|  . ... .|.||  . |.... .|.....  |       ...|..|.|  |. |..|...  ...||.  ....|  ....|
ddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkk

MRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCL
.| ||.|...    . . .||.|.||||||..|
lReqRpgmvqtpeqylflyralleylklkltkl
0051299 (Phosphotyrosine protein) phosphatases II 90-412 4.6e-51 169.4 In-house 24-287 (288) alignment 
Range on Protein: 90-412
Range on HMM: 24-287/288.0
SLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKV
 |   |.. |... . ....  ...|..||| .|.   | .||.|.....      ..  .|||||.|.. | .  .|.||.|||.|. |||.||.  .|
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg......vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

TQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRAVEVdqrcKNWMN
. .... ... .. .                                                    ..||  ...|... . .... .||    .. . 
rvIvmltklvelgrek................................................caqYwpl..ggsltygditvtllseev....lddyt

KYTVEVVAD----GCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
..|.||.      |..|  . ... .|.||  ..||... .|...|.  |  .    ...||.|.|  |..|..|...  ...||.. ....|  .....
vrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkr

MRDQRAGVFTMSIFFTYAIRAALFYLK
.| || |....   . . ..|.|.|||
lreqRpgmvqtpeqyrfvyealleylk
DSPc_SM00195 91-412 4.4e-72 237.9 In-house 2-263 (263) alignment 
Range on Protein: 91-412
Range on HMM: 2-263/263.0
LNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVT
|...|.  ....||...| .|..||..||| |.....| ||| |...||.      . . ||||..|...| . .||.||.|||||..|||.||. .||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk......egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

QVITIFEPIKDEAIEEFANFPAPAspvpppptasskdigsspdQQPREREQIEIKSIRCDNHLhqsffplstdhylnlegwlintravevdqrckNWMNK
......|. ... ..   ..|  .                   ... . ..|..| ......                                 .....
iivmlteeeengkekcdrywpees...................ggketfgkisvklvevekkk................................deiil

YTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQR
.|.|. ..|..|......|....||....||. |.||.|.||  |..| .   ..|..|.|. |..|..|.|...||.... ..|..|........|.||
rtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

AGVFTMSIFFTYAIRAALFYLK
.|..... .......|.|.|.|
pgmvqtleqYlfiyeaileyik
PTPc_SM00194 91-412 4.4e-72 237.9 In-house 2-263 (263) alignment 
Range on Protein: 91-412
Range on HMM: 2-263/263.0
LNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVT
|...|.  ....||...| .|..||..||| |.....| ||| |...||.      . . ||||..|...| . .||.||.|||||..|||.||. .||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk......egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

QVITIFEPIKDEAIEEFANFPAPAspvpppptasskdigsspdQQPREREQIEIKSIRCDNHLhqsffplstdhylnlegwlintravevdqrckNWMNK
......|. ... ..   ..|  .                   ... . ..|..| ......                                 .....
iivmlteeeengkekcdrywpees...................ggketfgkisvklvevekkk................................deiil

YTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQR
.|.|. ..|..|......|....||....||. |.||.|.||  |..| .   ..|..|.|. |..|..|.|...||.... ..|..|........|.||
rtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

AGVFTMSIFFTYAIRAALFYLK
.|..... .......|.|.|.|
pgmvqtleqYlfiyeaileyik
0045098 (Phosphotyrosine protein) phosphatases II 93-413 6.8e-45 149.0 In-house 11-274 (278) alignment 
Range on Protein: 93-413
Range on HMM: 11-274/278.0
TYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVltnpekskmgpaddveGYINASHIRFDnaSTDYILTQYPLPSTIRDFWKMVYVTKVTQV
..|. .|. ..||..|.. ...|..||| ||.  .| .||.                .|||||.|..   .. .|.||.|||||. |||.|..  ..| .
lefefllllgipseitpalylgnldknRykdilpydhsrVk................dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvi

ITIFEPIKDEaieefanfpapaspvpppptasskdigsspdqqprereqieiksircdN-HLHQSFFPlstDHYLNLEGWLINTRAVEVDqrCKNWMNKY
... | . ..                                                . . .| . .   ...|. ... ...  .||    . .. ..
vmltelvelg................................................rekcaqywpe...ggsltygdftvtllseevl..ddytlrtl

TVEVV--ADGCSEATFAKVYNCTTWPWKSYPDDV--KKVLALVRAPVKESS----------PTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVldGKTP
.|. .   .   |  . .......||  . |..   | .| |..   .  .           . ... ||.| |  |..|..|.|.  ...|..  ... 
lvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggv

DCDDLFRKMRDQRAG-VFTMSIFFTYAIRAALFYLKL
| .. ....| || | ....  .. . ....| .|. 
dlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 93-195 3.5e-14 47.6 In-house 23-122 (319) alignment 
Range on Protein: 93-195
Range on HMM: 23-122/319.0
TYFDAN---LANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmGpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKV
|... .   | . .. . .  . |.| .||| .... .| |||||.. . .. |       |||||.|   .  . .| || ||  || |||.||.  ..
tllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgve.g.....sdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

TQVITI
  |. .
sivvml
0047943 (Phosphotyrosine protein) phosphatases II 95-411 1.3e-51 171.1 In-house 18-272 (273) alignment 
Range on Protein: 95-411
Range on HMM: 18-272/273.0
FDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpA----DdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVT
|.. | .. . .... ....| .||| ||.   | .||.|               |    |||||.... | .  .|.||.|||.|. |||.||.  .|.
felllslkplltysvallpenkdknrykdilpydhsrvkl..........gdggsd....yinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

QVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLSTDH-YLNLEGWLINTRAVEVdqrcKNWMN
 .... |.. .. .                                                 .  ..||. .. .|. . . .... .|.    |... 
viVmLtelvelgrek................................................caqYwpleggelsltygkftvtllseet....kddyt

KYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQ
..|.|..  |..|  . ... .|.||  . |.... .| .... |..   .. ...||.|.|  |. |..|...  ....|.  ....| .......|.|
vrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel.vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

RAGVFTMSIFFTYAIRAALFYL
| |...   .. . ..|.|.||
Rpgmvqtpeqyrflyealleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 95-196 1.7e-17 58.5 In-house 28-123 (307) alignment 
Range on Protein: 95-196
Range on HMM: 28-123/307.0
FDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPekskmgPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
..   |. .. .... | . |  ||| .|.|  | |||.|..       . ..   |||||.|.  . . ..|  | |. .|| |||.|.   .|| .. 
yekLeareidkstkvsekkenalknRyedikafDktRvkLkki......ngkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

IF
. 
ls
subfamily_egg_pd Subfamily egg 96-408 2e-12 41.4 In-house 23-267 (307) alignment 
Range on Protein: 96-408
Range on HMM: 23-267/307.0
DANLANYSPSKCTFNEweKNVNKNRTKDVKLIDATRVVLTNPEKSKMGpaddveGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVtQVITI
  ....  . . ....   | .| |.| |.  | .|| |  ..   ..       .| | ... .    ..||.| ||  |  |||.||.  .| | | .
leesvdeislttaasd..nnlekarskrvhckdssrvklelrrGqyld......dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeev.qyivm

FEPIKDEaieefanfpapaspvpppptasskdigsspdqqprereqieiksircdNHLhQSFFPLSTDHYLNLEGWLINTRAVEVDQRCKNWMNKYTVEV
..  |.                                                 ..  . ..| . .. | .    ..  ...||..    ..   . .
ltsrkes................................................erc.eyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl

VADGcSEATFAKVYNcttWPWKsYPDDVKKVLALVRAPVKESSptvgkqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGktPDCDDL----FRKMRDQRA
|     |  | . ..   . .. .  ||   | ..|   . |        ||.| . ||  ..||.|   | . ..| |  |    |       .| .| 
vGgd.deerflehwq...gdvn.nssdvysplrvlrklrnlsk.......pvvvqdilGvskaatlvaieiallsllrG..pitkslvlravvflrlrrr

GVFTMSIFFTYAIRAAL
      . . .  |  |
lsvesvllylfvyrlvl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 96-196 6.6e-12 39.6 In-house 28-115 (303) alignment 
Range on Protein: 96-196
Range on HMM: 28-115/303.0
DANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmgpaddvEGYINASHIRFDnASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
  ....| | . . |.. ||..|||  ||  .| ..| |..              || ||.. .| .|   |||| ||. |  |||.|.   ||  |. .
fekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd............ssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlll

F
.
l
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 96-194 4.7e-10 33.8 In-house 14-106 (297) alignment 
Range on Protein: 96-194
Range on HMM: 14-106/297.0
DANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmGPAD-DvegYINASHIRFDNAST--DYILTQYPLPSTIRDFWKMVYVTKVTQV
|. | .  . . .    .  . ||| .|.   | ||| | .      .... |   |||| .. | .  .   |||.| || .|. |||..|.   |  .
dllldeargesfssakrnsslrknryrdilatddtrvkllr......viterd...yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvi

IT
. 
vm
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 97-197 1.1e-13 45.6 In-house 22-118 (301) alignment 
Range on Protein: 97-197
Range on HMM: 22-118/301.0
ANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKMgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
 .| .... .|| .  |.| . || |... .|  |..|.. .. ..      . |||||.|   . .. .| .| |. .|..|||....  |....... 
kelkegedksctvglseenkalnrfknitvyddnriilkpkpnldl....cqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

E
.
n
0043336 (Phosphotyrosine protein) phosphatases II 98-411 1.2e-49 164.7 In-house 28-277 (278) alignment 
Range on Protein: 98-411
Range on HMM: 28-277/278.0
NLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
.| .. .  ... ....|..|||.||. . | .||.|..       . |   .|||||.. . | ....|.||.|||.|. |||.||.  .|| .... |
ellsfkldtysiallpenkdknrykdilpydhsrvklsl......lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

PIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPlstDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVA
.  .. .                                                  . ..|   ...|. ... .... .|.    ....  .| ||. 
lvelgrvk................................................caqYwp...ggsltygdftvtllkeeh....lddytvrtlevtn

DGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMS
 |..|  .  .| .. ||  . |.... .| ...|  .  .    .. ||.|.|  |..|..|...  ...||. .....| .. ....| ||.| ... 
lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

IFFTYAIRAALFYL
 .. . ..|.|.||
sqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 98-416 5.9e-48 159.2 In-house 40-294 (297) alignment 
Range on Protein: 98-416
Range on HMM: 40-294/297.0
NLANYSPSkCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgPADDVEGYINASHIRFDNA-STDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
.| .. |. ... ....|..||| ||.   | .||.|. ..       |    |||||.. . .  . ..|.||.|||.|. |||.||.  .|| .... 
ellslkpd.ysiallpenkdknrykdilpydhsrvklkped.....gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLt

EPIKDEaieefanfpapaspvpppptasskdigsspdqqprereqieiksircdNhLHQSFFPLSTDhylNLEGWLINTRAVEVdqrcKNWMNKYTVEVV
... ..                                                .   ....| ...   . ... .... ||.    .. .. .| ||.
klvelg................................................r.kcaqywpeegg...tygdftvtllkveh....ldgytvrtlevt

ADGCSeaTFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTM
 .|.|   . ... .| ||. . |.... .| ....  .  . . .|. ||.|.|  |..|..|...  ...||.  ....| .. ....| || |....
nnges..rtvthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt

SIFFTYAIRAALFYLKLKLQ
  .. . ..|.|..|| ||.
psqyrflydallellkrklt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 98-197 1.6e-10 35.1 In-house 19-114 (281) alignment 
Range on Protein: 98-197
Range on HMM: 19-114/281.0
NLANYSPSK-CTFNEWEKNVNKNRTKDVKLIDATRVVLtnpeKSKMgPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
||    ||  ||  .   | .|||  ..  .| .|| |    | || |  .   || | .||       ||||| |   |  |||.|..  . | .. . 
nlpgdppsdlctvfnqpvnnkknrylnipcldisrvql....kvkm.pnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

E
.
q
subfamily_PTPRN_pd Subfamily PTPRN 99-206 2.1e-13 44.6 In-house 38-141 (297) alignment 
Range on Protein: 99-206
Range on HMM: 38-141/297.0
LANYSP--SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|..|    | ..  . ||||.|||.|.|   | .|| |..        ... . ||||| |   |  .. || || ||.||. |||.||.   |. ....
lcayeaepstkevakaeknvkknrskavlpydhsrvklkeea......saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

FePIKDEAIEE
  ....| ...
t.rleeegvkq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 99-202 1.9e-11 38.1 In-house 37-132 (290) alignment 
Range on Protein: 99-202
Range on HMM: 37-132/290.0
LANYSPSKCT-FNEWEKNV--NKNRTKDVKLIDATRVVLTNpekskMGPADdvegYINASHIRFDNAstDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|  | |..    . ..||   .||| |||   | |||.| .      .. |    |. | ...  .|   .|||| .| .|. |.|.||  .||. .. .
lkpylpvqylerkifdkntefkknrykdvvcndktrvilkd.....GydGd....yvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivml

FEPIKDE
 | |.| 
celiedG
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 100-196 1.3e-12 42.3 In-house 29-119 (315) alignment 
Range on Protein: 100-196
Range on HMM: 29-119/315.0
ANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
 .  ... .    . | .||| |..  .| .||.|   ..|   | .|   |||||.|.  .    || .| ||.... |||.||. .||| .. . 
pdPdiyrqrvaretinfkknryknilPldsarvklevidds...Pdsd...yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt
subfamily_PTPRG_pd Subfamily PTPRG 102-211 5.8e-17 56.1 In-house 34-138 (563) alignment 
Range on Protein: 102-211
Range on HMM: 34-138/563.0
YSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKD
 .  .... . ..| .|||. ..  .| .|| |..         ..   ||||..|   . | ..| ||.||..|. |||.|..  .|. ...| .  ..
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgk.....kkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlver

EAIEEFANFP
.. ...  .|
grrkcdvYWP
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 102-196 2.7e-13 44.6 In-house 34-118 (287) alignment 
Range on Protein: 102-196
Range on HMM: 34-118/287.0
YSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTnpekskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
 .. . | |  ..| .||| ...   |  ||.|           .  . ||||..|   . .  .|... |. .|.|.|||..   .|| .. . 
qredevthniasqnkdknRltqilvpdnyrvllk..........gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc
0045450 (Phosphotyrosine protein) phosphatases II 103-411 1.8e-48 161.2 In-house 43-304 (307) alignment 
Range on Protein: 103-411
Range on HMM: 43-304/307.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHI--------RFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
 . .... ....| .||| ||. . | |||.|.....|     ..  .|||||..         . . .. .|.||.|||.|. |||.|..  .|| ...
llgeysiallpenkdknrykdilpydhtRVklssldgs.....ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivm

IFEPIKdeaieefanfpapaspvpppptasskdigsspdqqprereqieiksirCDNHLHQSFFPLStDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVE
. |..                                                 ...     ..|.. ...|. . . .... .|.    .. .  .|.|
ltelve................................................lgrekcaqywPde.geeltygnftvtllseeh....ldgytvrtle

VVAD-GCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKeSSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT---PDCDDLFRKMRDQR
|    |..|  . ... .|.||  . |.... .|.....  |    . .|. ||.|.|  |..|..|...  ....|. ...|   .| .. ....|.||
vtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR

AGVFTMSIFFTYAIRAALFYL
 |...   .. . ..|.|..|
pgavqnpeqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 103-195 1.2e-17 58.8 In-house 36-122 (564) alignment 
Range on Protein: 103-195
Range on HMM: 36-122/564.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
. ....  . . | .||| ...   |..||||.. |.       .   |||||.|   ...  || || ||..||.|||.||.  ... .. .
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd......egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 103-202 3.5e-14 47.4 In-house 34-129 (290) alignment 
Range on Protein: 103-202
Range on HMM: 34-129/290.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpeksKMGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDE
|. . | .  ..| ..|| ... . |  |..| .    . |  |  . ||||..|   . . .||.|| |...|..||||...  ||| .. . . |...
sehtvtvgltssnkllnRfanivvyddnritLrp....isghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieeg
subfamily_ptpA1_pd Subfamily ptpA1 103-193 1.3e-09 32.3 In-house 35-118 (418) alignment 
Range on Protein: 103-193
Range on HMM: 35-118/418.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkSKMGpaddvEGYINASHIRFdNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
 ||. .  . ..| .|||  ..  .. ||| | . .  | |       |||| .|       ..| || ||| || |||.||.  ..  ..
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiq.dkeg.....sdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriiv
subfamily_PTPN3_pd Subfamily PTPN3 104-195 9.9e-15 49.2 In-house 30-115 (280) alignment 
Range on Protein: 104-195
Range on HMM: 30-115/280.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADdvegYINASHIRFDNAS----TDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
  ...     .|..||| .|.   ||||| |.. |      .|    ||||... ..  |    . || || ||..|  |||.||.  |.. .. .
glaisaarkpenlsknryrdilpydatrvklkese......td....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 104-193 4.8e-14 47.0 In-house 9-93 (270) alignment 
Range on Protein: 104-193
Range on HMM: 9-93/270.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpE---KskmgpaDDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
.|. .. |. .. . || .|.    ||||.|   |   .      |..  |||| ..| ||.... || .. |||.|...||.|.. .||| ..
tsesdlpeaargkklnRyadiLPsPatRvrl...eelee......dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaiv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 104-194 6.7e-12 39.6 In-house 41-124 (310) alignment 
Range on Protein: 104-194
Range on HMM: 41-124/310.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpEKSKMgpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
 |  |.. ..|.. |||  ||   |..|| |.  .||.       | || | ... .   . .| .| ||  || |||.|..  .   .. 
dssltyeaykkymhknrysdvvcldtsrvklki.dksry......edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesill
subfamily_PTPRA_pd Subfamily PTPRA 104-195 1.2e-11 39.1 In-house 47-132 (330) alignment 
Range on Protein: 104-195
Range on HMM: 47-132/330.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
 . .   . |.| .|||  ..   | .||.|.. |        .   |||||.|   .    .| .| |.  |. |||.|..  | . .. .
qatlelaskeenkeknrvvnilPydfsrvilsvkeGv......eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativml
subfamily_CG7180_pd Subfamily CG7180 104-196 2.6e-11 37.7 In-house 31-117 (296) alignment 
Range on Protein: 104-196
Range on HMM: 31-117/296.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmGPADDVegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
  .|  .  ..| .|||  .|   | .||||.. .    | ...   ||||...       .|| |. |  .|. .||..||  ..  |. . 
igdCagglrkenreknrdvkvvPyDynRvvLekld....Geeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt
0046845 (Phosphotyrosine protein) phosphatases II 105-419 1.6e-49 164.2 In-house 18-282 (284) alignment 
Range on Protein: 105-419
Range on HMM: 18-282/284.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHIRFD-----NASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
 ....  ...|..||| ||.   | .||.|......     ..  .|||||....      . .  .|.||.|||.|. |||.||.  .|. .... |..
lslsvallpenlsknRykdilpydhsRVklksldgd.....ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelv

KDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLStDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVADG
 .. .                                                 .  ..||. ...|..... .... .||    |... ..|.|..  |
engrek................................................caqYwple.gevltygdftvtllseev....kddytvrtleltnlg

-CSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK---TPDCDDLFRKMRDQRAGVFT
 ..|  . ... .|.||  . |.... .|...|. |.|. . .....|..|.|  |. |..|...  ...||.  ..   ..|  ......|.|| | ..
ytgesrtvthfhytswpdhgvppspedlleflrl.vrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

MSIFFTYAIRAALFYLKLKLQCLN
.   . . ..|.|.||||||..|.
tleqyrfvyealleylklkltlle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 105-391 4.7e-17 56.5 In-house 35-216 (392) alignment 
Range on Protein: 105-391
Range on HMM: 35-216/392.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEpIKDEAi
.. |  . | |..||| |..  .|..||.|   . .   | .|   |.|||.|.  ..   || .| | .... |||.||.  .|| .. . . .|.   
ypqtvaqkeinlkknryknilpydsarvkleviddi...pdsd...ylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtk.lkegd.

eefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvaDGCSEAT
                                                                                              | .  |
.............................................................................................kgddart

FAKvYNCTTWPWKSYPDDVKKVLALvrapVKESSPTVGKQP-PVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRA
 |. .  | || |  |  .  .| .    .|| .   |.   |.|. |  |. |.. |.    .. .    .  |  ..  ..| .| 
vaq.fhftewPdkdvpkhtssllkf....ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp
subfamily_PTPN1_pd Subfamily PTPN1 105-211 1.7e-16 54.8 In-house 22-118 (290) alignment 
Range on Protein: 105-211
Range on HMM: 22-118/290.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaddveGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAI
 ...  . ..| |.|| .||.  | .|..| . ..           ||||| . ...|   ||||| |||.|.  ||.||.  |   |. . . .  | |
fptreaklpenrnlnryrdvspydhsrikleradn..........dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

EEFANFP
  .  .|
kcaqywP
subfamily_PTPN13_pd Subfamily PTPN13 105-195 3.4e-15 51.0 In-house 27-108 (273) alignment 
Range on Protein: 105-195
Range on HMM: 27-108/273.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaddvegYINASHIRF--DNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
 .|.  . ..| .||| ..|  .|.||| | .              |||||.|.   ..   .||..| ||| |..|||.||.  |.. .. .
dtcevgkkkenkdknryrnvlPydetrvklgdegg...........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 105-195 4.5e-12 40.9 In-house 51-135 (319) alignment 
Range on Protein: 105-195
Range on HMM: 51-135/319.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpeKSKMGpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
.. || . ..| .|||  ..   | ..| |    .   |   .   |||||..        || .| ||. |. |||.|..  ... .. .
adqtfanldqnkdknriinilafdknvvkl....erliG..eefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 105-207 3.3e-10 34.4 In-house 23-114 (267) alignment 
Range on Protein: 105-207
Range on HMM: 23-114/267.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaddvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTqVITIFEPIKDEAI
|...    ||| ..||  |.   | |||.| . |.           |||||..   .    .|.|| ||  || ||....   ||. || .  ..  . |
stisqsiaeknqernrlddnlpyddtrvilrtkeee..........yinasyvegyktknafivtqdplkntitdfltvihdqkvp.vivlltkvftdni

EEF
  |
rlf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 105-199 3.4e-09 31.2 In-house 33-117 (288) alignment 
Range on Protein: 105-199
Range on HMM: 33-117/288.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTnpekskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
|. . ... .|  ..| ...   |.||| |.          || . ||.|  .   .     | .| || .||  .|||. .. |  .. . | .
sidiidsfianptrdryenlprcditrvkls..........ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcell
0040439 (Phosphotyrosine protein) phosphatases II 106-411 1.6e-44 147.8 In-house 2-246 (249) alignment 
Range on Protein: 106-411
Range on HMM: 2-246/249.0
KCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIE
.... ....|..||| .|.   | .||.|.  ..          .|||||.| . . ....|.||.|||.|. |||.|..  ..| .... ..   . . 
eysvallpenkdknrypdilpydhsrvklsilpg......lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrek

efanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVADGCSEATF
                                                 . ..||  ...|. ... .... |||    |...  .|.|..  ...|   
................................................caqywpl..ggsleygdftvtllsvev....kddytvrtleltnlydgesrt

AKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIR
 .....| ||  . |.... .|....|  |  . . .|. ||.|.|  |..|..|...  ...||.   .. | .. ....|.|| |....  .. . ..
vlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflye

AALFYL
|.|..|
allell
subfamily_PTPRB_pd Subfamily PTPRB 106-392 4.2e-25 83.4 In-house 42-266 (293) alignment 
Range on Protein: 106-392
Range on HMM: 42-266/293.0
KCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKMgpaDDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIE
.....| ..| .||| ...   |..|| |.. ....    .|   ||||..|.  |.  ..| || |||.|. |||.||. .|.. .. . . .    . 
avkaaelavnraknrytnilpydhsrvkLaalkdesg...sD...YinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvk

EFANFPAPaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylnleGWLINTRAVEVDQRCKNWMNKYTVE-VVADGCSEAT
    .||                                                            ..   ..|.   .. ......  .     .| .
CeeYWPad........................................................eepvlyGdikvtlvaeeeledwvirelkiekekeer

FAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAG
  . |. |.||    |.. |..|..||. |.|.  .  .. |..| |  |. |. | .    ..... .  . |   .  ..| .|. 
kvrqyhftsWpdhgvPektktlldfvrt.vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 106-195 4.3e-12 41.1 In-house 16-99 (284) alignment 
Range on Protein: 106-195
Range on HMM: 16-99/284.0
KCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpeKSKMGpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
. || . ..| .|||  ..   | ..| |    .  .|   .   |||||.|        || || ||. |. |||.|..  ... .. .
dqtfanldqnkdknrighilafdknvvkl....erliG..eefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 106-196 1.4e-09 31.9 In-house 89-168 (244) alignment 
Range on Protein: 106-196
Range on HMM: 89-168/244.0
KCTFNewEKNVNKNRTKDVKLIDATRVVLTnpeKSKMGpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTqVITIF
| .||   .|  |||      .|  || |.   |. ||     . ||||| .     ...|||||.||  |  |||||.   .|  |. ..
kdafn..pnnswknregaglpfdfnrvpls...kgsmg.....ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvn.vlvvl
0042113 (Phosphotyrosine protein) phosphatases II 107-412 3e-43 143.4 In-house 1-244 (245) alignment 
Range on Protein: 107-412
Range on HMM: 1-244/245.0
CTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKMGPaddvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEe
... ....|..||| .|. . | |||.|.... .   .      |||||.. ... .  .|.||.|||.|. |||.|..  ..| .... |.  .. .  
ysvallpenkdknrysdilpydhtrvklspdggdldsd......yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvk.

fanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVADGCSEATFA
                                                . ..||  ...|. ... .... .|.    ....  .|.||. .|..|  . 
...............................................caqywpl..gesltygdftvtllseeh....lddytvrtlevtnlgddesrev

KVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
 .| .. ||  . ||... .| ....  |  .   ... ||.|.|  |..|..|...  ...||.   .. . .. ....|.|| |....  .. . ..|
ihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

ALFYLK
.|..||
llellk
0037934 (Phosphotyrosine protein) phosphatases II 107-411 1e-29 99.3 In-house 2-242 (243) alignment 
Range on Protein: 107-411
Range on HMM: 2-242/243.0
CTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpaDDvEGYINASHIRFDNastDYILTQYPLPSTIRD----FWKMVYVTKVTQVITIFEPIKDE
...  .. |..||| .|. . | .||.|           .. ..||||..|.  .    .|.||.|||.|. |    ||.|..  ..| .... |..  .
fsiallpenlsknrysdilpydhsrvkl...........eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElg

AIeefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhLHQSFFPlstDHYlNLEGWLINTRAVEVdqrCKNwMNKYTVEV-VADGCS
..                                                    ..|   . . . ... ...  .|.   ... .  .|...   |   
re................................................kcaqywp...gev.tygdftvtllseeh...ldd.ytvrtlllenldldd

EATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSP-----TVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVldgkTPDCDDLFRKMRDQRAG-VFT
.  .   | .. ||  . ||... .|.....  .  .      .  .. ||.|.|  |..|..|...  ......    . | .. ....|.|| | ...
ltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavq

MSIFFTYAIRAALFYL
   .. . ..|.|..|
tpsqyrflyeallell
0049772 (Phosphotyrosine protein) phosphatases II 107-412 1.7e-16 56.3 In-house 38-281 (314) alignment 
Range on Protein: 107-412
Range on HMM: 38-281/314.0
CTFNEWEKNVNKNRTKDVKLIDaTRVVLTnpekskMGPADDvEGYINASHIRFDnasTDYILTQYPLPSTIRDF----------WKMV--YVTKVTQ---
...   ..| .|||..|.   | .||.|         | ..  .|||||...      ..| ||.||. |. ||          |.||  .  .|     
ilvadlflnrdknryldilpad.nrvilp......glpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

----------------------------VitifepikdeaieefanfpapaspvpppptasskdigsspdQQPREREQI--Eiksircdnhlhqsffpls
                                                                       .| ....   .                  
srdevladelsrLdaAlgKtpllildgng.........................................neptaadlellk..................

tdhylnlegwlintravE-----------------------------VdqrcknwmnkytvevvadgcseatfakvyncttwpwksypddVKKVLALVRA
                 |                                                                        ....|.....
.................eelydpelferlgikylripvpDgsaplled..........................................fdeflefiee

PvKessptvgKQPPVIVMCDLGLDRSAT-VVLTSIIIEQvldgKTpDCDDLFRKMRDQRA-----GVFTMSIFFTYAIRAALFYLK
  .       |. ||.| |  | .|..| ||.  ... .    .  . .. .. .| .|      | . . . . .  .| | |||
a.d.......kggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 107-195 5.7e-09 29.9 In-house 38-122 (439) alignment 
Range on Protein: 107-195
Range on HMM: 38-122/439.0
C--TFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|  ..   | .  ||| |||   | |||.| .       |      |||| .|.       || ||.|   |  |||..|.  |.......
ciaslaaqeydqtknrykdvgafdhtrvtlqe......ipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 108-197 2.9e-12 40.5 In-house 36-119 (515) alignment 
Range on Protein: 108-197
Range on HMM: 36-119/515.0
TFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
|  . | | .||| |..  .| .|| |   . .   |  |   |.|||.|.  ..   || .| |..... |||..|.  .|| .. . .
tvaqeeinfkknryknilPydsvrvklevindn...Phsd...yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 108-195 2.1e-10 35.2 In-house 44-123 (297) alignment 
Range on Protein: 108-195
Range on HMM: 44-123/297.0
TFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNAstDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|  |   | .|.| |..  .|  || |   ...   |  |   |.|||...  .    .| || | ..|. |||.||.  .|. .. .
tvaekkvnfeksRYkniLPydssRvkLaivndd...pdsD...yvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 108-197 5.6e-09 30.1 In-house 42-121 (305) alignment 
Range on Protein: 108-197
Range on HMM: 42-121/305.0
TFNEwEKNVNKNRTKDVKLIDATRVVLTNPEkskmgPADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
.| |  .. .||| |||  .|  || | .|      | .    || | ..     .  .| || ||  |  ||| | .  || ... . .
afke.aqeagknrykdvgcldnnrvklegpw.....phe....yihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 109-197 4.1e-16 53.9 In-house 41-123 (288) alignment 
Range on Protein: 109-197
Range on HMM: 41-123/288.0
FNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
  .  .| .||| ...  .| .|| |.. |.       . . |||||.|  .. .  || || ||..|. |||..|| .|.. .. . |
agrlavnakknRyrnilpyDekrvklkklee......eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmlte
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 109-216 2.2e-15 51.2 In-house 30-132 (287) alignment 
Range on Protein: 109-216
Range on HMM: 30-132/287.0
FNEW--EKNVNKNRTKDVKLIDATRVVLTNpeKSKMGPAddvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEE
| .     .|.|||  ||  || |||.|..  ....| .     |||| ..   .    .| .| |...|.||||..|. |... |||.   ...   . 
fkaaeelaavkknryadvlPiddtrvllsa..egelGsd.....yinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

FANFPAPASP
.  .| .  |
ykywPerevP
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 109-202 2e-13 44.9 In-house 27-112 (283) alignment 
Range on Protein: 109-202
Range on HMM: 27-112/283.0
FNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaddveGYINASHIR---FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITiFEPIKDE
 .  ..| .||| ...   |  || | .  .           ||||..|     .. . .|| .| ||  |..||||||.  |.| ..  . .....
iasadenkrknrnqeivpadqwrvelksesr..........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm.ltklqed
subfamily_PTPN12_pd Subfamily PTPN12 110-194 7e-18 59.5 In-house 35-113 (290) alignment 
Range on Protein: 110-194
Range on HMM: 35-113/290.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmgpaddVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
 | |.||.||| ||.   | .||.|.. |...       ..||||..|.  . .. || .| ||| |. |||.|.. ..|. |. 
gekeenvkknrykDilPydksrvelskieeee......gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvm
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 110-206 8.5e-18 59.6 In-house 51-140 (298) alignment 
Range on Protein: 110-206
Range on HMM: 51-140/298.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVtQVITIFEPIKDEAIEE
 . ..| .|||  |.  .| .||||.. .      ||.   |||||..   . .. .|.||.||..|. |||.||   .. ..| .......    .
arkpenkkkNRyadiialdssRvvLeked......adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi.gtiVmltnleeldktk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 110-204 6e-17 56.7 In-house 36-124 (281) alignment 
Range on Protein: 110-204
Range on HMM: 36-124/281.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmgpaddVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAI
 . ..||.||| ...   |||||..|. |..|         ||||...   .  ..|| || |.|... .||.||. .||.... . . |. . .
skadenvlknrYsnivaYDatrvkvtpneenk......ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagkl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 110-197 3.5e-06 21.4 In-house 13-100 (290) alignment 
Range on Protein: 110-197
Range on HMM: 13-100/290.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEKsKMgpaddVEGYINASHIRFDNAsTDYILTQYPL-------PSTIRDFWKMVYVTKVTQVITIFE
 .. |. ....  .| |. |||||| .  | ..     ...|| |... . |     |||| |.        ||| .|| |.   ||.||. . |
tdyvkkhemdqRlevpLveatrvvLkgygk.rf.....nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlce
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 112-195 1.8e-14 48.6 In-house 43-120 (318) alignment 
Range on Protein: 112-195
Range on HMM: 43-120/318.0
WEKNVNKNRTKDVKLIDATRVVLTNPEKSKMgpADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
 . | .|||  ..   | ||| |.. |...   .|    ||||..|   ...  || .| ||| ||.|||.||.  . . ....
epvnkaknryanilaydhtrvkLqmlegeeg..sD....yinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml
subfamily_PTPRK_pd Subfamily PTPRK 112-197 2.4e-14 47.9 In-house 40-119 (314) alignment 
Range on Protein: 112-197
Range on HMM: 40-119/314.0
WEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
 ..| .|||..|.   | .||.|.  .       |    ||||. |   . .. .| ||.||..|..|||..||  . . .. . |
kdenreknrsgdilaydrsrvflitid......gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 113-412 1.9e-27 91.0 In-house 26-269 (274) alignment 
Range on Protein: 113-412
Range on HMM: 26-269/274.0
EKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIfEPIKDEAI-EEFANF
 .. .||| |..   . .||.|.. . .     |.   |||| .|. .|. |. |. || |||.|. |||.|.| ..|. .. .   .|..        |
fgsqtknryktilPnensrvllesesse.....dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml.tklkeaneqkCavyf

PapaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylN-----L-------EgwlintraveVDQRCKNWMNKYTVE-VVA
|                                                       .     .       |          .  . ..  |.|.|. .| 
P.......................................................daedyeiserygdve..........ikvekiverndysvrklvl

DGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMS
  ...    | |  | || .  |||....| ||.   .. . .  |  ||.| |  |. |    . .|| . |. . .. |   .  ..| .| |.   |
kylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

IFFTYAIRAALFYLK
  . .  ||   |||
eqyelihralclylk
subfamily_PTPN23_pd Subfamily PTPN23 113-198 2.6e-16 54.3 In-house 41-117 (288) alignment 
Range on Protein: 113-198
Range on HMM: 41-117/288.0
EKNVNKNRTKDVKLIDATRVVLTnpekskmGPADDvegYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEP
.....||| .|.   | .||.|        |  ||   |||||...     . |.| || ||.||. |||.|||  |.  .. . ..
klyseknrsrdilPyDhnRvklr.......gskDD...YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllsk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 113-193 8.6e-15 49.6 In-house 7-81 (250) alignment 
Range on Protein: 113-193
Range on HMM: 7-81/250.0
EKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
 .| .|||  |.  .| .|||| . .      .|.   |||||..   . .  .| || ||..|| |||.||.  |.. ..
pqnkeknryadiialdssrvvLekek......gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtiv
subfamily_PTPN6_pd Subfamily PTPN6 113-192 7.9e-13 43.1 In-house 52-126 (306) alignment 
Range on Protein: 113-192
Range on HMM: 52-126/306.0
EKNVNKNRTKDVKLIDATRVVLTnpEKSKMGpaddvEGYINASHIR--FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQV
 .| .||| | .   | |||.|.  |.| .|     . ||||. |.  . . .. || ||  |..|. |||.||.  . . .
penkeknryknilPfDhtrvilk..epsvpg.....sdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 113-197 4.2e-12 40.8 In-house 46-126 (325) alignment 
Range on Protein: 113-197
Range on HMM: 46-126/325.0
EKNVNKNRTKDVKLIDATRVVLTNpekSKMGPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVY--VTKVTQVITIFE
 .|..||| |.|  .| .||||      |  |  |   |||||..| |     .. .| ||..|| |.|..|.   . |  |. ...
penkaknrfknvvaldksrvvlet...kkddpssd...yinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneld
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 113-199 4.6e-07 23.8 In-house 53-131 (305) alignment 
Range on Protein: 113-199
Range on HMM: 53-131/305.0
EKNVNKNRTKDVKLIDATRVVLTNPEkskmgPADdvegYINASHIRFDN-ASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
. .. ||| .||   | . | | .|      |.|    || | ..         .| .| ||  || .|| ||   || |.. .   .
diaitknryqdvpcqdqsavkldkps.....psd....yihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 114-199 1.3e-11 39.0 In-house 48-127 (315) alignment 
Range on Protein: 114-199
Range on HMM: 48-127/315.0
KNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
.|..|||  ..   | .|| |   |.      |.   |.||. |   |    || .| |......|||..|.  ...... . . .
enkqknryiniiaydksrvqlpllen......dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 114-196 2.4e-10 35.0 In-house 2-77 (237) alignment 
Range on Protein: 114-196
Range on HMM: 2-77/237.0
KNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaddvEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
.|  |||  ...  | .||||  .  .          ||||.... || .   || .| || |.  |||.||.  | . .. . 
enkiknrygnivaydhsrvvlkgagsg........sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmlt
0041856 (Phosphotyrosine protein) phosphatases II 115-411 6.5e-22 73.4 In-house 1-171 (182) alignment 
Range on Protein: 115-411
Range on HMM: 1-171/182.0
NVNKNRTKDVKLIDATRvvltnpekskmgpaddVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFepikdeaieE----Fanf
|..|||..|.  .| .|                .  ||||. ....  .|..|.|| ||.||. ||..|..  ..| ....          |        
nldknrysdilpydhsr................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...

papaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseA---TFAK
                                                                                                    
............................................................................................ellerlgi

VYNCTTWPWKSYPDdVKKVLALVRAPVKessptvgKQPPVIVMCDLGLDRSATVVLTSIIIEQvldgkTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAA
 | .. ||  . || . ..|.....  .       .. ||.| |  |..|..|.|.  .....       . .. .. .| .| |....  .. .  .|.
qylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlal

LFYL
|..|
lell
Y_phosphatase Protein-tyrosine phosphatase 115-201 4.1e-20 67.6 Pfam-A 1-79 (235) alignment 
Range on Protein: 115-201
Range on HMM: 1-79/235.0
NVNKNRTKDVKLIDATRVVLtnpeKSKMGPADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKD
| .||| ||.  .| ||| |    |.. || |    ||||....  . .  .|.|| ||.||| |||.||.  ||. .... .  . 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek
Y_phosphatase Protein-tyrosine phosphatase 115-201 4.1e-20 67.6 In-house 1-79 (235) alignment 
Range on Protein: 115-201
Range on HMM: 1-79/235.0
NVNKNRTKDVKLIDATRVVLtnpeKSKMGPADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKD
| .||| ||.  .| ||| |    |.. || |    ||||....  . .  .|.|| ||.||| |||.||.  ||. .... .  . 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 115-195 2e-11 38.3 In-house 47-135 (350) alignment 
Range on Protein: 115-195
Range on HMM: 47-135/350.0
NVNKNRTKDVKLIDATRVVLTNPEKSKMGPAD--DVEGYINASHIRFD------NASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
   ||| |..   . .|| | .  ||  .       . ||||....        |..  || || |||||. ||.|...  ||. ....
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl
subfamily_eak_pd Subfamily eak 115-207 1e-08 29.0 In-house 52-135 (332) alignment 
Range on Protein: 115-207
Range on HMM: 52-135/332.0
NVNKNrTKDVKLIDATRVVLTNPEKSKmgpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKdEAIEEF
.||.|   ..   |   | ||.  . .       .|||||| . | .    ||||  .  . .  ||.||.  |   .. . | .. . .|..
avnrn.vvkivpydrylvrltssqlnr.......lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve.lkleks
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 115-193 5.3e-07 24.1 In-house 8-81 (239) alignment 
Range on Protein: 115-193
Range on HMM: 8-81/239.0
NVNKNRTKDVKLIDATRVVLtnpEKSKMGPADDvegYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
|  |||  ..   | .||||   ||    |  |   |||||..| .| .   || ||  .  .  |||.|..  .   ..
nkaknryanivtydhsrvvl...eklsndphsd...yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 115-193 5.6e-07 23.9 In-house 7-80 (239) alignment 
Range on Protein: 115-193
Range on HMM: 7-80/239.0
NVNKNRTKDVKLIDATRVVLtnpEKSKMGPADDvegYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
|  |||  ..   | .||||   ||    |  |   |||||..| .| .   || ||  .  .  |||.|..  .   ..
nkaknryanivtydhsrvvl...eklsndphsd...yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 116-195 1.1e-09 32.1 In-house 49-138 (349) alignment 
Range on Protein: 116-195
Range on HMM: 49-138/349.0
VNKNRTKDVKLIDATRVVLTNPEKSKMGP--------ADDVEGYINASHIRFDNASTD--YILTQYPLPSTIRDFWKMVYVTKVTQVITI
  ||| ||.   . .||.| .  ||  .         .  .. |||| .... . |..  || || |||||. ||.|..   .|  |. .
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL
subfamily_CG42327_pd Subfamily CG42327 120-209 5e-08 27.0 In-house 33-116 (319) alignment 
Range on Protein: 120-209
Range on HMM: 33-116/319.0
RTKDVKLIDATRVVLtnpeksKMGPADDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIkDEAIEEFAN
|  .|  .  |||||      .  . || . |..||..| .|.| . || .| .| ..  |||..|.  .   .... ..  .  |.  |.
rvinvvPlPetrvvl......qrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls.elGikvcae
0043147 (Phosphotyrosine protein) phosphatases II 147-402 1.6e-17 59.2 In-house 3-152 (172) alignment 
Range on Protein: 147-402
Range on HMM: 3-152/172.0
DVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPikdeaieefanfpapaspvpppptasskdigsspdqqprereqieiks
. . |||||.. .    ...| ||.||..|. |||.|..  ..| .... |                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

ircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevVADGCSEATFAKVYNCTTWPWKSYPdDVKKVLALVRAPVKESspTVGKQPP
                                                 . |.  .  .   | .. ||  . | . . .| ...   .     . .. |
.................................................lydpellerlgiqylylpwpDhgvp.llellleflefidell..alspggp

VIVMCDLGLDRSATVVLTSIIIeqvldgKTPDCDDLFRKMRDQRAGVFTMSIFFTY
|.| |  |..|..|.|.  ...      .  . .. .. .|..| |...   .  .
vlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf
0051429 (Phosphotyrosine protein) phosphatases II 148-413 1.3e-16 56.5 In-house 3-227 (272) alignment 
Range on Protein: 148-413
Range on HMM: 3-227/272.0
VEGYINASHIRFDnasT------DYILTQYPLPSTIRDFWKMvYVTKVTQVITIFEPIKDEAIEEFANFPapaspvpppptasskdigsspdqqprereq
..|||||...      .       ......||| |..|||.. .  ... .... ..   ..   .   |                              
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywp..............................

ieiksircdnHLHQSFFPLSTDHYLNLEGWLINTRAVEVDqRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYP-DDVKKVLALVRApvkesspt
          ...  ..|.  |..   . . .  . ...   . ...  . . .   . .||    .. .| ||  ..| . ....|.|...        
..........girylhlpilddsaptilygalrvtllsee.llldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld........

vgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPD--------CDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKL
   . ||.| |  | ||..|||.  .....| .    |         ..  ...|.||.|..    .. .  .|.| .|. 
...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
0051082 (Phosphotyrosine protein) phosphatases II 148-402 1.4e-10 36.4 In-house 2-144 (151) alignment 
Range on Protein: 148-402
Range on HMM: 2-144/151.0
VEGYINASHIRFDnastdYILTQYPLPstirDFWKMVYVTKVTQVITIFEPIKDE---AIEEFANfpapaspvpppptasskdigsspdqqprereqiei
...|||.| .        ......||.    ||.....  ... .... ..   .    . . ..                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

ksircdnhlhQ-------------SffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfakvyncttwpWKSYPDDVKKVLALVR
                        .                                                              ..| |...| |..
..........ievlhipildwpdpg...........................................................lplsfdavleflelll

ApvkessptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQvldgktPDCDDLFRKMRDQRAGVFTMSIFFTY
.          |. ||.| |  |..|..|.|.  .....       . .. .. .| .| ||.. .  | .
d.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 149-197 2.7e-06 21.7 In-house 13-60 (130) alignment 
Range on Protein: 149-197
Range on HMM: 13-60/130.0
EGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVtQVITIFE
. ||||| .   . ...|.||| ||  |  |||||.    |  |. .. 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryv.nvlvvlg
0036282 (Phosphotyrosine protein) phosphatases II 150-402 9e-15 50.3 In-house 3-161 (174) alignment 
Range on Protein: 150-402
Range on HMM: 3-161/174.0
GYINASHIRFDNASTDYILTQYPLPstirdFWKMVYVTKVTQVITIFEPIKDEAIEEFANFPApaspvpppptasskdigsspdqqprereqieiksirc
 |||||.. .   .. .|..|.||.     ||.|..  ..| |..  |.. ..    .  .|                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

dnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvaDGCSEATFAKVYNCTTWPWKSYPDDVKkVLALVRAPVKESSPtvGKQPPVIV
                                                .  ..  .   | .. ||  . ||. . .| .|..  .  |   ... ||.|
................................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlV

MCDLGLDRSATVVLTSIIIEQVLdGKTPDCDDLFRKMRDQRAGVFTMSIFFTY
 |  |..|..|.|.  ... . |  .. |  ||.|..| || |....  .. .
HCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
0044763 (Phosphotyrosine protein) phosphatases II 150-398 1.1e-11 40.2 In-house 19-158 (178) alignment 
Range on Protein: 150-398
Range on HMM: 19-158/178.0
GYINASHIRfDNastdYILTQYPLpstiRDFWKMVYVTKVTQVITIFEPIKDEAIEEFANFPAPASpvpppptasskdigsspdqqprereqieiksirc
 |||||.|  ..    ..|...|      |......  ..| .... |..    ..... .|  |.                                  
dyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..................................

dnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfaKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIV
                                                           | .. .|  . ||  . .|..|..  .  .    |. ||.|
.........................................................iqylhipipDhgvpdllehflefvefieeald...ekggpvlV

MCDLGLDRSATVVLTSIIIEQvldgkTPDCDDLFRKMRDQRAgVFTMSI
 |  |..||.|.|.  .....       . .. .. .| .|  ...   
HCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg
0046846 (Phosphotyrosine protein) phosphatases II 151-411 4e-13 45.0 In-house 14-173 (176) alignment 
Range on Protein: 151-411
Range on HMM: 14-173/176.0
YINASHIRFDnastDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEEFAN--------Fpapaspvpppptasskdigsspdqqprereqi
||||. |  .     .| ||.|||.|. ||..|..  ..| |... |..  . .  .          .                                
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................................

eiksircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfakVYNCTTWPWKSYPDDvKKVLALVRAPVKESSPTvg
                                                                  | .. ||  . ||. . .| |...  .  .    
.................................................................qylhlpwpDhgvpdl.elllellefirealkeg..

kqPPVIVMCDLGLDRSATVVLTSIIIEqvldGKTPDCDDLFRKMRDQRA-GVFTMSIFFTYAIRAALFYL
   ||.| |  |. |..|.|.  ...     .|  . .. ....|.||  |...   .  .  ...|..|
..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 152-198 6.5e-06 20.1 In-house 78-124 (301) alignment 
Range on Protein: 152-198
Range on HMM: 78-124/301.0
INASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEP
| |  |  .  .  .| || ||..|  ||| |.   .| ... . . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqk
0049260 (Phosphotyrosine protein) phosphatases II 162-400 2.6e-13 45.4 In-house 7-139 (152) alignment 
Range on Protein: 162-400
Range on HMM: 7-139/152.0
ASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEEFANFpapaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffpls
 .. .| ||.|.| |. |||.|..  ..| .... |.  .  . .   .                                                   
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................

tdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfakVYNCTTWPWKSYPDDVKKVLALVRAPVKEsspTVGKQPPVIVMCDLGLDRSATV
                                               | .. ||  . ||.   .| |...  |       |. ||.| |  |..|..|.
..............................................qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtl

VLTSIIIeqvldgKTPDCDDLFRKMRDQRAGVFTMSIFF
|.  ...      .  . .. .. .| .| |...   . 
vaaylml......lgvsleeavalvrekRpgavpnpgql
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 248-416 1.5e-21 71.1 In-house 129-290 (302) alignment 
Range on Protein: 248-416
Range on HMM: 129-290/302.0
RCDNhLHQSFFPLSTDHYLNLEGWLINTRAVEVDQRCKnwmNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVkeSSPTVGKQPPV
 ...   . .||. .. |.. .   .|.| ||  .  |   ..|..||. .|||.. .|.|| .| |. |. |. . .. . .   |     ..  . ..
elkk.tlselfpkksgdykeygkmfvNnrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaak.v..fakkikadent

IVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQ
...   |  | ....   . .|.. .|| |   .. ...| ||. .    . ..   .|.|.|.| |..
vivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 251-395 5.8e-07 23.5 In-house 129-266 (301) alignment 
Range on Protein: 251-395
Range on HMM: 129-266/301.0
NHLHQSFFPLSTDHYLNLEGWLINTRAVEvdQRCKNWMNKYTVEVVAD-GCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESsptvgkQPPVIV
.. .....|... . |... . |...  |  .  .. ..| |.||.   |  ..     |. ..|. .  |    ..  |.   ||.|      . |..|
eekceeylpvkisekldigrfkikiknke..lilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmel.vkks......ekPivv

MCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRA-GVFT
 |  |. || . . | ..  .|.  .| .  . ....|..|  || |
hcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 254-400 7.4e-09 30.1 In-house 94-229 (239) alignment 
Range on Protein: 254-400
Range on HMM: 94-229/239.0
HQsFFPLSTDHYLNLEGWLINTRaVEVDQrcknWMNKYTVEVVadGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQpPVIVMCDL
|| ..| || .| ||   | .|  |  |      .  . .  |  | .|  .   |  | || |  |.    || | |   |.| |  | . | .. |  
hq.ywpdstskycnlrvtlrkte.vfady....iirtfvmsqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp..gar.pwvihcsa

GLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFF
|. |. ....   .. |    || |  .  . .|..|  .   |  .
gvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 254-399 8.1e-09 30.0 In-house 95-229 (239) alignment 
Range on Protein: 254-399
Range on HMM: 95-229/239.0
HQsFFPLSTDHYLNLEGWLINTRaVEVDQrcknWMNKYTVEVVadGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQpPVIVMCDL
|| ..| || .| ||   | .|  |  |      .  . .  |  | .|  .   |  | || |  |.    || | |   |.| |  | . | .. |  
hq.ywpdstskycnlrvtlrkte.vfady....iirtfvmsqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp..gar.pwvihcsa

GLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIF
|. |. ....   .. |    || |  .  . .|..|  .   |  
gvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseq
Y_phosphatase Protein-tyrosine phosphatase 255-406 1.4e-17 59.3 Pfam-A 85-232 (235) alignment 
Range on Protein: 255-406
Range on HMM: 85-232/235.0
QSFFPLSTDHYLNLEGWLINTRavevdQRCKNWMNK---YTVEVVADGCS-EA-TFaKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptVGKQPPVIV
. ..| ... .|. .   ....     .. |.....   ...|.  .. . |  .. |.. .|.|| .. |...|..| |.|.  |..     |. ||.|
aqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvV

MCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
.|  |  |..|.|. .|..||. .....|  .. ...| ||.|...    . . ..|
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 255-406 1.4e-17 59.3 In-house 85-232 (235) alignment 
Range on Protein: 255-406
Range on HMM: 85-232/235.0
QSFFPLSTDHYLNLEGWLINTRavevdQRCKNWMNK---YTVEVVADGCS-EA-TFaKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptVGKQPPVIV
. ..| ... .|. .   ....     .. |.....   ...|.  .. . |  .. |.. .|.|| .. |...|..| |.|.  |..     |. ||.|
aqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvV

MCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
.|  |  |..|.|. .|..||. .....|  .. ...| ||.|...    . . ..|
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 255-434 8.1e-08 26.7 In-house 114-283 (290) alignment 
Range on Protein: 255-434
Range on HMM: 114-283/290.0
QSFFPLSTDHYLNLEGWLINTRAVEVDQRcknwMNKYTVEVVADGCSEATFAKvYNCTTWPWKSYPDDVKKVLALVRApVKEssptvgKQPPVIVMCDLG
. ..| | .  |...|  ..    | ..     ... ...|  |.  | |.   .    |   . ..| | .|.|..  ||       .. |||| |  |
akYvpesvgeelkfkgltvkCkskekedd....vetRelvvkfddeeeftvtH.sllkgWnklnvqedtktllsliqk.vka......sktpvivHcvdG

LDRSATVVLTSIIIEQVL-DGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLNENGNE-DVKTMITEAL
. |||..    .    .    .     |.  ..| ||| ..|  . ..... .......  |.   |. .|  .|.  .|..
iSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeekety
subfamily_PTPN1_pd Subfamily PTPN1 257-395 1.7e-06 22.0 In-house 116-255 (290) alignment 
Range on Protein: 257-395
Range on HMM: 116-255/290.0
FFPLSTD-HYLNLEGWLINTRAVEVDQRCKNWMNkyTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGL
..|   . . | ||   .. . .. ... .  ..  ..|.    . |.     .  ||||  . |.   . | ..   |.||   . .. |... |  |.
ywPqgeeekellledtklkvkliseerksyytvr..llelenlktqetreilhfhyttwpdfgvpespaaflkflfk.vresGslssdvGpavihcsaGi

DRSATVVLTSIIIEQVLDGK---TPDCDDLFRKMRDQRAGVFT
 || |..|   .. .. . .   . |  . . ..| .| |.  
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 258-414 1.1e-08 29.4 In-house 110-267 (270) alignment 
Range on Protein: 258-414
Range on HMM: 110-267/270.0
FPLSTDHYLNLEGWLINTRAVEVDQRckNWMNKYTVEVVADGCSEATFakVYNCTTWPWKSYPDDVK------KVLALVRApVKESSPTVGKQPPVIVMC
.| .... ..||   |...|..  ..  .   .  ...  .| ..      .  .||| .. | .        ..|...|| |..|.    |. |..| |
Wpaepkekvkledgkikvlalseeke..egyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlra.vrrsekeldkaePllvHc

DLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLK
  |..|. |.... |... .   |  |.  . ...| .|  .   .  .... .| . | . .
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 259-406 1.8e-08 28.4 In-house 141-278 (290) alignment 
Range on Protein: 259-406
Range on HMM: 141-278/290.0
PLSTDHYLNLEGWLINTrAVEVDQRCKNWMNKYTVEVVADGCSeaTFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptvGkqpPVIVMCDLGLDRS
|    . | .  . .   . | |.  .  ..  .|  . .| .     | ..  .|| || .     .| ..|.  | |    |   ||.| |  |. |.
pekeGevltfGeitvlc.seeddkdaniikktlsvrdkdsGke..hklkhlkikswpdksvalstlallrtlrilrkas....G...pvvvhcsaGiGrt

ATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
 | |   . .. .||||  |  || | .|. |..   . | .   ...
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalvei
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 270-432 2.1e-07 23.9 In-house 175-330 (346) alignment 
Range on Protein: 270-432
Range on HMM: 175-330/346.0
GWLINTRAVEVDQRCKnwmnKYTVEVVADGCSEATFAKVYNCTTWPWKSYPddvKKVLALVRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIE
  .|| |  .|    |    .||.||. .| |..  ..|.  . |     |    | | ...   .  |    ..  | |.  .|  |. . . .   |.
kmfinnrradvsgdpk....eytievlpegnsdsvicqvhhhapwkhlqqp...pktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyain

QVLDGKTPDCDDLFRKMRDQRAGVFTmsIFFTY-AIRAALF-YLKLKLQCLNENGNEDVKTMITE
|. .|  |.  ........|| |      |  | .| | .| |.  |    ..  | |.. .| |
qlnngiepniceimknikqqrpggve..sfaqyasiyaivfdyiarkrggkkapvnkdinrfide
subfamily_PTPRK_pd Subfamily PTPRK 273-394 1.3e-07 25.7 In-house 142-260 (314) alignment 
Range on Protein: 273-394
Range on HMM: 142-260/314.0
INTRAVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVL
|.   ||..  ..  .  ..|| .| | .|    . .. ..||    |   . .|.|||  ||.|..   .. ...| |  |  |. | .  .|... . 
ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr.vkksqee..eaGrivvhCsaGaGrtGtfiaidivldmie

DGKTPDCDDLFRKMRDQRAGVF
  .. |     ...|...  . 
regvvdvfnavktlrsrkvnmv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 277-437 1e-09 32.6 In-house 149-299 (312) alignment 
Range on Protein: 277-437
Range on HMM: 149-299/312.0
AVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKEssptvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT
 .|.  . |. . .  . ||     . .  . |. ..|| .  || .   | |. |  |.       . |||  |  |. |. |..|   .|  .   . 
eieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd.......kkpviahcsagvgrtgtlaliesmiaalrhprk

PDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKlqCLNeNGNEDVKTMITEALAKV
 .  | |  .| .||    .   . ||.|. | .|  |   |  . ||.  | . |. ||.
qnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk..gly.krneqewtkfketyaki
subfamily_PTPN12_pd Subfamily PTPN12 278-420 1.4e-09 32.3 In-house 142-286 (290) alignment 
Range on Protein: 278-420
Range on HMM: 142-286/290.0
VEVDQRCKNWMN-KYTVEVVADGC-SEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK
.||..  .....  ...  ..  . .|    . .. | || .  |  .|..|.|... |.|      .. |..| |  |  |  |..   .. |.. ..|
fevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssakslleliel.vrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaek

TPDCDDLF---RKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLNE
.|.. |.|   ...| ||| .      ...  .| . ... .|. ..|
ipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 284-402 2.9e-08 28.1 In-house 154-270 (288) alignment 
Range on Protein: 284-402
Range on HMM: 154-270/288.0
CKNWMNKYTVEVVADG--CSEATfAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDD
 .. ....... .  .   .| .  . |. ..|| .. |.. . .|.|.|  || ...    . |.|| |  |. |. | .    .|..|   .. |  .
eskeledfvlrklllekkktele.itqyqylaWpdhgvPeskapllellrq.vkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvag

LFRKMRDQRAGVFTMSIFFTY
   |.| ||| .      . .
tvaklRkqRallvqtlkqYef
subfamily_PTPN23_pd Subfamily PTPN23 284-404 1.4e-07 25.7 In-house 152-273 (288) alignment 
Range on Protein: 284-404
Range on HMM: 152-273/288.0
CKNWMnKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVK-ESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK-TPDCDD
 .... ......   . ..    .  . |.||    |.  ...|... .  .  ..     . |..| |  | .|. .. |   .....  |.  .|  .
tethv.ervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiq

LFRKMRDQRAGVFTMSIFFTYAI
.....| ||  .   .  .  . 
vvsrlreqRrfmvqekeqlkfsy
subfamily_PTPN13_pd Subfamily PTPN13 286-412 2.7e-09 31.7 In-house 148-270 (273) alignment 
Range on Protein: 286-412
Range on HMM: 148-270/273.0
NWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
. ..  ...|     .|.      | ..||  . |   ...| .|.  |..      .. |..| |  |. || |..   .... .   |  |  .. ||
dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqt...dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk

MRDQRAGVFTMSIFFTYAIRAALFYLK
.|.|| ||   .  . .  .|.|  ||
lreqrqgvvqtkdqyifvykailevlk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 287-404 6.9e-07 23.5 In-house 150-265 (285) alignment 
Range on Protein: 287-404
Range on HMM: 150-265/285.0
WMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKM
 .|  ||    | .||  . .  .   || .  |.| . .. | .  ||.  |   |. |. | |  |. |.||.|       ....    .  |. |.|
ilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykw.vkkvnp...kekpicvhcsagvgrtatfvgidyatirimenpniemldivrem

RDQRAGVF--TMSIFFTYAI
|  |       | ..| | .
ramrfqavqshmqflflyvv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 288-393 9.8e-12 39.5 In-house 156-262 (318) alignment 
Range on Protein: 288-393
Range on HMM: 156-262/318.0
MNKYT---VEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFR
...|.   ..|  ....|    . |..|.|| .. |... ..|.|||  |..   . |.. |..| |  |  |  . .  .|..|.. . .. |  .  .
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq.vskaqqksgag.pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvk

KMRDQRAGV
..|.||  .
qlreqrnlm
subfamily_PTPRA_pd Subfamily PTPRA 288-410 5.5e-07 23.8 In-house 173-294 (330) alignment 
Range on Protein: 288-410
Range on HMM: 173-294/330.0
MNKYTVEVVADGCSEA--TFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
. |. |. ..|.. |      . .  |.||    | . . .| |... ||.  .  .   |..| |  |  |. | .  . ..|.|   .  |  .  ..
vrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk.vkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkr

MRDQRAGVFTMSIFFTYAIRAALFY
.| ||. .      ...  .. | |
lrlqrpqmvqtdeqyefiykvlley
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 289-411 9.8e-08 26.3 In-house 163-277 (307) alignment 
Range on Protein: 289-411
Range on HMM: 163-277/307.0
NKYTVEVVADGCSEAtfAKVYNCTTWPWKSYPDDVKKVLALVRApvkesspTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT-PDCDDLFRKMR
|  |..|.  . | .   . .. . || .  |.     . |. |       . ... ||.| |  |. || |.|  |.. .....|.   | ..| ...|
nvttlkvdwaqksrt..iqhlqwenwpdrgvpqinltainllea.......vrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelr

DQRAGVFTMSIFFTYAIRAALFYL
.||       . . |  |  | |.
sqrhyaiqteaqylylhrvlleyf
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 289-415 1.7e-07 25.6 In-house 156-280 (281) alignment 
Range on Protein: 289-415
Range on HMM: 156-280/281.0
NKYTVEVVADGCSEATFAKVyNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKqPPVIVMCDLGLDRSATVVLTSIIIEQVLDG-KTPDCDDLFRKMR
 . .... .... . . ... . |.|| .  |.. |..|   .. |.. . .  |  |... |  |  |. | .    ....| .  .. | ... ...|
ierkfkleresgetreveql.aytaWPdhGvPattkellefrke.vlkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelr

DQRAGVFTMSIFFTYAIRAALFYLKLKL
 .|  .    . ...  .| | .|. .|
kernlmvqtvvqyefvykavldaldkel
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 290-396 7.2e-07 23.6 In-house 163-269 (297) alignment 
Range on Protein: 290-396
Range on HMM: 163-269/297.0
KYTVEVVADGCSEATFAKVYNCTTWPWKSYPD--DVKKVLALVrAPVKESSPTVGKQpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMR
| ..||  .      . | |. . || |. .   .....| |.   |...  .. .  |..| |  |. | . ..    .. .. . |. |  .| .|.|
krelevtkgkakarrvvkqyqfveWPdkaverkdsassllkli.sevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklr

DQRAGVFTM
..|  .   
qerpylvqt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 292-406 1.9e-08 28.4 In-house 174-282 (305) alignment 
Range on Protein: 292-406
Range on HMM: 174-282/305.0
TVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRapvkESSPTVGkqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT-PDCDDLFRKMRDQR
|| |.    ..|  .. |    || .  |     .| |.     .. |. |   |..| |  |. |. .||.   |..|.| |.   |.| ...|.|.||
tvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskg...pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

AGVFTMSIFFTYAIRA
         . .  . 
nnsiqtdaqylfvhqv
subfamily_PTPRD_pd Subfamily PTPRD 296-393 1.2e-09 32.4 In-house 169-263 (564) alignment 
Range on Protein: 296-393
Range on HMM: 169-263/564.0
VADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGV
     ||.   . .. | || .  |.  ...|.|.|  |.....   .. |..| |  |  |. | .  ....|.. . || |     ...| ||  .
kkkkssesreVrqFhFtsWPdhgvpesatslLdlirk.vralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnam
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 297-395 1.3e-07 26.1 In-house 171-267 (305) alignment 
Range on Protein: 297-395
Range on HMM: 171-267/305.0
ADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFT
.|. .|      |. |.|| .  |.    .| |..   |. .   .|. |..| |  |. |. . .  .| .|..   .. |  .. ...| .| .. .
ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvq
subfamily_PTPRG_pd Subfamily PTPRG 300-402 3e-07 24.0 In-house 179-278 (563) alignment 
Range on Protein: 300-402
Range on HMM: 179-278/563.0
CSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTVGkqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIF
| .    . |..|.|| .. |.    ||  |.   .    ..|   |..| |. |  |. | .  . ...|. . .. .  .. ...| ||  ...    
cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaG...PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEq

FTY
...
Yif
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 301-415 6.3e-08 27.0 In-house 168-275 (288) alignment 
Range on Protein: 301-415
Range on HMM: 168-275/288.0
SEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPvkessptVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFF
 |. . |.     |. .. |.. .  | |.             | |..|..  |  |..|..|. |..|..          |. |.|..|    .    .
eekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqy

TYAIRAALFYLKLKL
 |. |  | .| || 
lyvhrcvleelllkk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 302-411 1.1e-10 36.2 In-house 183-290 (298) alignment 
Range on Protein: 302-411
Range on HMM: 183-290/298.0
EATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKEsSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFT
.    .  . |.|| |. |   . ||.|.|  |.  |..  .. |||| |  | .|| | .  . ..|.|   .. |  .  . .| .|.|. .    ..
kerevrqlhftsWpdkgvpenatsvldllrk.vra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYv

YAIRAALFYL
.   | | .|
fiyeavleal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 302-391 2.5e-06 21.9 In-house 131-219 (237) alignment 
Range on Protein: 302-391
Range on HMM: 131-219/237.0
EATFAKVYNCTTWPWKSYPDDVKKVLALvRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRA
|  . . |. |.|| .  |.    .| . |  . . || | .  | |. |  |. |.. ...   .. |  . |  |  .    . ..| 
evrlihqyqftswpdrgvpqqtaallrf.rkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrp
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 304-410 4.4e-11 37.4 In-house 137-241 (250) alignment 
Range on Protein: 304-410
Range on HMM: 137-241/250.0
TFAKVYNCTTWPWKSYPDDVKKVLALVRaPVKESSPTVGKQpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYA
   . .. ..|| |. |.  . ||.|..  |. | . .|.. |||| |  |  || . .  . ..|..   |. |  .. ...| .| .. .    . . 
rivrqlhfvvWPdkgvPevatavLellk.kvqasqqqagna.PvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfv

IRAALFY
 ...| .
yeiilka
0048076 (Phosphotyrosine protein) phosphatases II 306-405 1.6e-07 26.7 In-house 47-137 (145) alignment 
Range on Protein: 306-405
Range on HMM: 47-137/145.0
AKVYNCTTWPWKSYPDDVKKVLALVRAPVK---EssptvgkQPPVIVMCDLGLDRSATVVLTSIIIEqvldgKTPDCDDLFRKMRDQRAGVFTMSIFFTY
   | .. ||  . ||. . .|.....  .   |         ||.| |  |..|..|.|.  ....     .  . .. ....| || |...   .. .
giqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

AIR
 ..
lye
PTPc_DSPc_SM00012 307-408 4.3e-19 64.0 In-house 3-104 (105) alignment 
Range on Protein: 307-408
Range on HMM: 3-104/105.0
KVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDG-KTPDCDDLFRKMRDQRAGVFTMSIFFTYAIR
|.| .|.||... |......| |.|| ||..    ....||.|.|  | .|..|.|. .|...|. .. |..|  ......|.||.|....   . . .|
khyhytgwpdhgvPeesdsilellra.vkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AAL
| |
all
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 307-404 1.4e-07 25.9 In-house 181-279 (319) alignment 
Range on Protein: 307-404
Range on HMM: 181-279/319.0
KVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSI---FFTYA
| .  | || .  |.. . .|.|..  ...|     .. |..| |  |  |  | .  ....|.|    . |     ...| ||  .        |  .|
khfqyteWpdhdvPekatslldllkr.irksrekt.qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyea

I
.
l
0048179 (Phosphotyrosine protein) phosphatases II 307-400 1.6e-06 23.4 In-house 50-134 (144) alignment 
Range on Protein: 307-400
Range on HMM: 50-134/144.0
KVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvgKQPPVIVMCDLGLDRSATVVLTSIIIeqvlD-GktPDCDDLFRKMRDQRAGVFTMSIFF
  | .. ||  . ||. . .|.....  .  .    .  ||.| |  |..|..|.|.  ...      |   . .. .. .| .| |...   ..
iqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgql
subfamily_PTPN6_pd Subfamily PTPN6 308-416 2.4e-09 31.6 In-house 190-302 (306) alignment 
Range on Protein: 308-416
Range on HMM: 190-302/306.0
VYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVG--KQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT---PDCDDLFRKMRDQRAGVFTMSIFFTY
 |. ..|| .. | | . ||....  |.. . ..   .. |..| |  |. |  |.... |.....   ..    |  .| ...|.|| |.  .   . .
qyhfksWPdhgvpkdpgavLdfled.vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykf

AIRAALFYLKLKLQ
  .|  .|.. | .
vykaikkyietkkk
subfamily_Ptp69D_pd Subfamily Ptp69D 308-410 7.5e-09 30.1 In-house 186-285 (307) alignment 
Range on Protein: 308-410
Range on HMM: 186-285/307.0
VYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAA
 |. |.|.    |.  . .| |..   .  .     . |..| | .| .||...|  .....|.   .. |  .  ...| ||  ...    ...  || 
qyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

LFY
| |
ldy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 308-404 1.5e-06 21.9 In-house 178-272 (439) alignment 
Range on Protein: 308-404
Range on HMM: 178-272/439.0
VYNCTTWPWKSYPDDVKKVLALVRApvKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAI
 .  ..|| |  | .   || ..||   .|.    .  ||.| |  |. |. |..   | .||.   .  | . . . .|.||  .      . .  
qfhyiawpdknvpaqashvldflra..insandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiy
subfamily_PTPN9_pd Subfamily PTPN9 310-408 1.5e-06 22.5 In-house 179-287 (297) alignment 
Range on Protein: 310-408
Range on HMM: 179-287/297.0
NCTTWPWKSYPDDVKKVLA---LVR-------APVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIF
  ..||    |.. ...|     ||         . ...    ..||..| |  |. |. | .   | .... .  | |  .  ...| |||    .   
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq

FTYAIRAAL
...   | |
yefcylavl
subfamily_PTPRN_pd Subfamily PTPRN 310-406 1.8e-06 21.9 In-house 193-287 (297) alignment 
Range on Protein: 310-406
Range on HMM: 193-287/297.0
NCTTWPWKSYPDDVKKVLALVRaPVKESspTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDG-KTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
   .|| .. |   | .| . |  |  |    |.  |..| |  |  |. . .|  ......| | |  |      ..||||.|.      | .|. |
hflswpeegvPasaksllefrr.kvnks..yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_PTPN3_pd Subfamily PTPN3 311-397 4.9e-09 30.5 In-house 178-261 (280) alignment 
Range on Protein: 311-397
Range on HMM: 178-261/280.0
CTTWPWKSYPDDVKKVLALVRApVKESSptVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMS
 . || .. ||| ...| .|.  |..     ||. ||.| |  |..|.  ..|  . .  .   .     |. |.|||||| .   .
ylaWpdhgvPddsadflefver.vrklr..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta
subfamily_PTPN14_pd Subfamily PTPN14 311-396 8.6e-09 29.8 In-house 190-281 (300) alignment 
Range on Protein: 311-396
Range on HMM: 190-281/300.0
CTTWPWKSYPDDVKKVLAL------VRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTM
 | || .  |.|||. |        ||  .......  ..|||.| |  |  |.  ..|. ..|. .  ... | .  ....| ||  .   
ytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 334-412 5.4e-08 26.8 In-house 211-290 (305) alignment 
Range on Protein: 334-412
Range on HMM: 211-290/305.0
VKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK-TPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLK
..  |   | . |..| |  |. |. |.|    |.|.. . |  |   .| . .|||||      . . .  |  | |. 
lellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 343-408 8.3e-07 23.1 In-house 227-292 (297) alignment 
Range on Protein: 343-408
Range on HMM: 227-292/297.0
KQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAAL
.. ...| |  |. ||  |||. .|....  .. ||   . ...|.||| .      |..   |.|
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl