Gene ptp-1 in Caenorhabditis elegans

Synonym: CELE_C48D5.2, ptp-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP159_AA protein Get Run
CeleP159_AA_735-1013 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 33-113 3.5e-25 78.1 Pfam-A 1-80 (80) alignment 
Range on Protein: 33-113
Range on HMM: 1-80/80.0
VTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFiavDNSSAQQKKWLDPSKNLRKQMIC--PPYHLFFRVKFYV
|..||.| ......... | ||||.|.. |...|..||||.|   .. ......|||..|.||.|.    .|. |..||||||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLaf...kedkknesnwLdhdktlreqgveegkpttlllrvkfyv
FERM_M FERM central domain 115-226 1.4e-21 67.1 Pfam-A 1-126 (126) alignment 
Range on Protein: 115-226
Range on HMM: 1-126/126.0
DPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFE-EKTHGMSR--TCLCY-----------KIQFATLPDDFSDRVAELHQLHI
|||...|| .. ..|.|....| |.||.|.| ...|||.. .|.|.||.| |...  |   . ...           ...     ...  |..| |. . 
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GQTPDVAEQNFLDHARRLEMYGMDVY
|.... |....|  |..|..||....
glslaeaklkylqaaqslpdyGvslF
FERM_C FERM C-terminal PH-like domain 232-318 1.5e-24 76.4 Pfam-A 3-89 (90) alignment 
Range on Protein: 232-318
Range on HMM: 3-89/90.0
NHLPIEIGVGAVGIKVFHEGIKM--NEYAWVRIRKLSFKKKQFQVLVANedGVSETIMIFNIMSAKICKLLWKCCIEQHTFFRLKTPPK
.   . .|| | |......  |.  ... | .|||||||.|.| . . .    ... . |.. .....|||.|.|||.|..|| . ...
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd..ekkkdvlkFyssqlrvnklllklcienhdlfrrrrkvd
FA FERM adjacent (FA) 323-368 2.6e-17 51.4 Pfam-A 2-46 (47) alignment 
Range on Protein: 323-368
Range on HMM: 2-46/47.0
KVFNFGSKFRYSGRTEYQTLEENEHrKSAGHRNFHRSLSKSSFLRS
|.| .|||||||||||.|..||. . ..  ...|.||.||..  |.
kffslGSkFRYSGRTekQvieesre.igrkppsfeRspskrylsrr
PDZ PDZ domain (Also known as DHR or GLGF) 618-703 2.3e-25 78.7 Pfam-A 2-81 (81) alignment 
Range on Protein: 618-703
Range on HMM: 2-81/81.0
IKMRPDRHGRFGFNVKGGADQN-YPVIVSRVAPGsSADKCQPrLNEGDQVLFIDGRDVSTMSHDHVVQFIRSARSglnggELHLTIR
... ....|..||..||| |..  ...||.| || .|..... |.|||..| ..|.||...|||..||.|.....     |..|||.
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg.....evtLtil
0039614 (Phosphotyrosine protein) phosphatases II 728-1010 1e-82 273.3 In-house 9-287 (297) alignment 
Range on Protein: 728-1010
Range on HMM: 9-287/297.0
ADSVPNSDKLSKSLQLLADSLNSGKVVDHFEMLYRKKPGmsMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS----GDYINANYVnmeiPSSGI-VNR
 .|.| . .    |.|| . ......  .||.|.. ||   . |..| .|  ||||.|. |||..|| |.  ..     |||||.||    .   .  ..
lesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrk

YIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRvKCHQYWPRVFEtqEYGRLMIKCIKDKQTTNCCYREFSIRDrnSSEERRVTQMQYIAWPDHG
.||.|||| .|  ||| |||||..|.|||||. .|.|| ||.||||   .  .||.. ....| ..  ....|......  ..|.| ||..||. |||||
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhg

VPDDPKHFIQFVDEVRKARQG--SVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
||........|...||.|..   .  |..||||||.||||..|.. .. ...|..  | .|..|...| || . .|||.|| |... .| 
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0051299 (Phosphotyrosine protein) phosphatases II 736-1010 1.6e-89 295.5 In-house 9-284 (288) alignment 
Range on Protein: 736-1010
Range on HMM: 9-284/288.0
KLSKSLQLLAdSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAH
.| | .. |    .  .. . ||.|....| .......| .|| ||||.|. |||..|| |.  ..   .|||||.|.    .   . ...||.|||| .
ellklvlkll.angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpn

TSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDR----NSSEERRVTQMQYIAWPDHGVPDDPK
| .||| |||||....|||||...|.||.||.||||   ....||........ ..  ....|.. ...      ..|.|.||...|..||||||||.|.
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

HFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
....|. .||||.. .  |.|||||||.||||..|..... ...| .. | .|..|...| || ...||| || ||.| .| 
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPN3_pd Subfamily PTPN3 737-1016 7.5e-149 489.2 In-house 1-279 (280) alignment 
Range on Protein: 737-1016
Range on HMM: 1-279/280.0
LSKSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNMEIPSSGIVNRYIACQGPLAHTSSD
|..||.||...|.||.|. .||.|||||||......|...||.||||||..|||.|||.|..|.. ||||||||||||||.|.||||||.|||||.|..|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatd

FWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDE
|| |||||....||||||..||||||||||||.  ...|||....|| |...|.....||. ..|....|||...|.||.||||||||||...|..||..
fWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefver

VRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGT
|||.|.|. .|.||||||||||||||||.||| .|.|..|||||||||||||||||||.||..||.||||.||..|....
vrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeil
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 737-1013 6.5e-70 230.7 In-house 10-284 (319) alignment 
Range on Protein: 737-1013
Range on HMM: 10-284/319.0
LSKSLQLLADslNSG-KVVDHFEMLYRKKPGmSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipSSGIVNRYIACQGPLAH
| . |. ||.  ..  ..   |..|   ..  ... .    |  ||||... .|| |||.|..   ... |||||....    .    ...|| |.||..
Lkerlkalas..tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlen

TSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFI
| .||| ||||... ..|||| ..|...||...|||.  . .|||||...  ..... .   |..... ..|  | |.|.. || .||||.||.. .  .
tiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QFVDEVRKARQG-SVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
... ..||.|.. .  |||||||||.||||  | .. .   |. .. .    .|...| || ...|.| ||.|. | .| | .
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0050432 (Phosphotyrosine protein) phosphatases II 739-1013 2.2e-94 311.5 In-house 30-300 (308) alignment 
Range on Protein: 739-1013
Range on HMM: 30-300/308.0
KSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLqaSPSGDYINANYVNMEIpsSGIVNRYIACQGPLAHTSSDFW
. |.|| . |..|..   || |...|| .......| .|  ||||.|. ||| .|| |  ... |||||.||.. .  |.. ...||.|||| .|  |||
dllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys..sklprkfIatqgPlpntvedFw

VMVWEQHCTTIVMLTTITERGRVKCHQYWPRV--FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDE
 |||||....|||||...|.||.||.||||     ...|||.. ..... ..  ....|.. ... ...|.|.||...|..|||||||..|.....|...
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VRKARQGsvDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
||| ..|   |||||||||.||||..|..... ...| .  | ....|...| ||.. .||| || |... .|  ..
vrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_PTPN14_pd Subfamily PTPN14 739-1010 2.1e-73 241.9 In-house 11-294 (300) alignment 
Range on Protein: 739-1010
Range on HMM: 11-294/300.0
KSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS--PSGDYINANYVNMEIpsSGIVNRYIACQGPLAHTSSD
|  . |   |..|||   .| . .|.    .. ..|  |  |||..|| ||.|.|| |...   | .||||  ... .  .|    ||..|||| .|  |
krakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv..ggkersyivaqgPleltvqd

FWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV---FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQF
|| |||||. . ||||| ..| |. |...|.|.     .| |.|.  .     .... .  . . ..   |.||| |  .||. |||||||.|.|.|...
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy

VDEVRKAR---QGSVD------PIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
..||.  |   . .|.      |..||||||.|||||||| .     .| || .    .....| || .|.|| .||.|| . ...
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
0036941 (Phosphotyrosine protein) phosphatases II 742-1016 1.6e-89 295.4 In-house 4-281 (297) alignment 
Range on Protein: 742-1016
Range on HMM: 4-281/297.0
QLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLqASPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMV
.|| ..|.. ..  .|| |.. .. .|... .| .|| ||||.|. |||.||| |  ... |||||.||    .  .. ...||.|||| .|  ||| ||
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmv

WEQHCTTIVMLTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQ--TTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVR
|||..|.|||||. .|.||.||.||||    |...||........ ..   .....|.. . | ...|.|.||...|. |||||||..|.....|...||
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KARQG--SVDPIVVHCSAGIGRTGVLILMETAACLVE---SNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGT
|...   |  |..||||||.||.|..|..... ...|    .. | .|..|...|.||.. .||..|| |..| .|  .  ..
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0047943 (Phosphotyrosine protein) phosphatases II 742-1009 1.7e-86 285.3 In-house 3-269 (273) alignment 
Range on Protein: 742-1009
Range on HMM: 3-269/273.0
QLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLqASPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMV
.|| ..|.....   ||.|.. || .......| .|. ||||.|. |||..|| |  ... |||||.||    .   . ...||.|||| .|  ||| ||
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmv

WEQHCTTIVMLTTITERGRVKCHQYWPRVFE--TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRK
|||....|||||...|.||.||.||||   .  ...||.. ..... ..  ... |.. ... ...|.| ||...|  |||||||........|...|||
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

ARQG--SVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|..   |  |.|||||||.||||..|..... ...| .  | .|..|. .|.|| . .||| || |..| .|
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
subfamily_PTPN13_pd Subfamily PTPN13 744-1011 5.4e-80 263.6 In-house 4-268 (273) alignment 
Range on Protein: 744-1011
Range on HMM: 4-268/273.0
LADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgdYINANYVNMEIpsSGIVNRYIACQGPLAHTSSDFWVMVWE
| . |....  . |. |   ||  . .. .  .| .|||||.| |||.|||.|... .  ||||.......       .|||||||| .| .||| ||||
lqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvwe

QHCTTIVMLTTITERGRVKCHQYWPRVFE--TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKAR
|... |.|.|.  |.|.||||.|||   .  .. ..|| .. .| ..  .   |.. ..| .|.| |.|.......|||||||  .....||| |||. .
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

QgSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
. .  ||||||||||||.|.|| ....  |.| ....   .|||..|.||  ..||  || || ..|| .
t.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 745-1008 3.2e-24 79.9 In-house 20-281 (302) alignment 
Range on Protein: 745-1008
Range on HMM: 20-281/302.0
ADSLNSGKVVDHFEMLYRKKPGMSMniCRL-TANLAKNRYRDVCPYDDTRVTLQASPsGDYINANYVnmEIPSSGivNRYIACQGPLAHTS---SDFWVM
 .||....| . |. .   |  . .  |..  .||.||.  ||  .|...| |.|.|  .|.||  |  |.|. .  .  |  | |   ..    .|| |
vksldtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep.dsyvnaskv..evPelt..rsiilaQlpkvdsedsveeFWrm

VWEQHCTTIVMLTTITERGRvKCHQYWPRVFET-QEYGRLMIKCIKDKQTTNCCyREFSI--RDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEV
|........|.|    |  .   ....|.  .. .|||....   | ... .    ...|     . |.   ..      |... ||.   . |. . .|
vfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

RKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
 .  . . ...|.    |.|| |... . .| . ..... .   .||...| ||.  ...  ||...  ..
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
0040438 (Phosphotyrosine protein) phosphatases II 746-1013 1.9e-88 292.1 In-house 13-277 (317) alignment 
Range on Protein: 746-1013
Range on HMM: 13-277/317.0
DSLNSGKVVDHFEMLYRKKPGmSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVW
. .. ... ..||.|.. |.  .... .| .|  ||||.|. |||..|| |.  ..    |||||.||    .   . ...||.|||| .|  ||| |||
lksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvw

EQHCTTIVMLTTITERGRVKCHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ
||..|.|||||. .|.||.||.||||   ||..||........ ..  ....|.. . | ..||.|.||...|..|||||||..|.....|...||.|..
eqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

GSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
..  |..||||||.||||..|..... ...| .. | . ..|...| ||.. .|||.|| |... .|  . 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
subfamily_PTPN6_pd Subfamily PTPN6 746-1009 1e-75 249.6 In-house 21-294 (306) alignment 
Range on Protein: 746-1009
Range on HMM: 21-294/306.0
DSLNSGKVVDHFEMLYRK--KPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL--QASPSGDYINANYVNMEIPSSGivNRYIACQGPLAHTSSDFWVMV
.||.   . ..|| | ..  |  .| .  . . |  ||||. . |.|.|||.|  .  |  |||||||.. |...|   ..||| || | .| |||| ||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmv

WEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIR-DRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKA
|..... |||.|. .|||. || .||| . |..|||.. ......|....  .||.|.   ....|||.| |... .||||||| ||.....|...|.. 
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrk

RQGSV----DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDI---VRTMRDQRAMLIQTPGQYTFVCESIL
.. .      |||||||||||||| .|....   |.|..   ...||   |...|.||  |.||  || || ..| 
qeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 747-1011 6.1e-75 246.9 In-house 12-275 (281) alignment 
Range on Protein: 747-1011
Range on HMM: 12-275/281.0
SLNSGkVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWE
. |.|  . ..| |.    . . .  .  .|  ||||.... || |||..   ... . ||||||.|    |.    ..|||.|||. ..  .|| ||||
ndnaG.fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv....pgykgekeyiatqgPvPaslvafWqmvwe

QHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIrDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG
|. ..|||.|   | |..|||.|||   .. .|| ...| .. .....   |.|.. .|.|.|.|.|.|..|.||||||||...|....| .||.|... 
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

SV-DPIVVHCSAGIGRTGVLILMETAACLVESN-EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
.   |.|.|||||.||||. | .....  ||.. |.. . ..|. .| .| ...||  ||.||   .|.|
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 748-1008 2.1e-41 136.6 In-house 12-289 (301) alignment 
Range on Protein: 748-1008
Range on HMM: 12-289/301.0
LNSGKVVDHFEMLYRKKPgMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNME-IPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHC
 .| |. .... |.....  |...    .| | ||.... .||| |..|.  |. |  . .|.| . | .    ...|| |||. .|  ||| ..|... 
khsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIVMLTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTTNCC-----------------YREFSIRDRNssEERRVTQMQYIAWPDHGVPDDPK
..|||.|   |. . ||.||||.   |..|.| . .. ....   .                    |.| .. ..  . . |.|.| . ||..||  .|.
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrepr

HFIQFVDEVRKARQ-GSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
  .| .|.| ...|  .  |.|||||....|.|| . .. .   . ..  |   ......| ..   ..|  |||.. . |
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 749-1013 2.4e-73 241.7 In-house 19-281 (288) alignment 
Range on Protein: 749-1013
Range on HMM: 19-281/288.0
NSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQH
|   ...... |   .   | .. ||. |  |||||.. ||| .|| |.     .. |||||.|.. |    .  ..||| |||||.|  ||| .|.|..
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenk

CTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRdrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV
 .|||||| . |.|. ||..|||   . ..|| . .. ...|....   |.. .    . .|...||.|| ||||||||.. . ...... |  | |  .
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadt

DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY-H
 ||.||||||.||||. | ....   ||... .  ...|  .| |||.|.||  || |. | .|    .
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Ptp69D_pd Subfamily Ptp69D 749-1012 2.5e-64 212.3 In-house 21-286 (307) alignment 
Range on Protein: 749-1012
Range on HMM: 21-286/307.0
NSGKVvDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQH
. |..   .|.| ...   | ..     |. |||| |. ..|.||| |.      . |||||....    .    ...|| |.|.  |  ||| |..||.
dfgla.keyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPveatigDfWRmiaeqe

CTTIVMLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-----SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKA
 |.||||. .||  | ||..|||   ....|| ...|... .....   ||...   .       ..|.|.| .| .|.|  ||. ..  ......||. 
vtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

RQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
 . .  ||||||||| ||.|... ..     .. .. |   ..|. .| || .|.|   ||.|.  ..|   
yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
0043336 (Phosphotyrosine protein) phosphatases II 750-1009 1.2e-82 272.8 In-house 19-274 (278) alignment 
Range on Protein: 750-1009
Range on HMM: 19-274/278.0
SGKVVDHFEMLYRKKPgMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHC
  ..  .|| |.. |. ....|..| .|  ||||.|. ||| .|| |.  ..    |||||.||    .   . ...||.|||| .|  ||| ||||...
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgv

TTIVMLTTITERGRVKCHQYWPrvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVD
|||||||. .|.|||||.||||   ....||.. ....| ..  ... | . . .. ..|.| ||...|..|||||||........|. .||.|.. |  
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsng

PIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|..||||||.||||..|..... ...|..  | ....|...| ||.. .||| || |..| .|
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_PTPRB_pd Subfamily PTPRB 751-1013 9.3e-82 269.3 In-house 25-286 (293) alignment 
Range on Protein: 751-1013
Range on HMM: 25-286/293.0
GKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCT
 ......|.|   .  ..... .|..| |||||... ||| .|| |   . ... |||||||    ||     . .||.|||| .|  ||| ||||....
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkss

TIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDrnSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKAR--QGSV
.||||| . |.|.|||..|||.  |.. || . .. ........   ||..|.   ..|||.|.|.....|||||||...| ...|| .||.|   . | 
iivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
 |||||||||.||||..| ...    .|... |  . ||  .| .|..|.||  || |. ...|.  .
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 751-1008 2.6e-62 205.7 In-house 22-279 (305) alignment 
Range on Protein: 751-1008
Range on HMM: 22-279/305.0
GKVVDHFEMLYRKkpGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGD---YINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCT
 ..  ....||..  . |... . .|| ||||.... ..|| |. |....| |   ||||.||.    .    ..||. |||| .| .||| ...| . .
kgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvs

TIVMLTTITERGRVKCHQYWPRVFET-QEYGRLMIKCIKDKQTTNCCYREFSIRD-RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV
|||||| . | |. ||.||||      .|.|.....    |....   |...|   ....|.| |.|.|   |||||||. .  .......|.|... . 
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

D-PIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
. |..||||||.||||| | .. |   ..  | |   ......| .|  ..||  ||.|. . .
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 751-1010 6.6e-42 138.6 In-house 16-275 (307) alignment 
Range on Protein: 751-1010
Range on HMM: 16-275/307.0
GKVVDHFEMLYRKKPGmSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS-PSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHCTTI
 ..|| |..| .|.|  ....  ..||  ||||.||   | .|. .. .  . ||| |||. . |      ...|..||||  |  .|| |. ...  ..
qalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiqekvesv

VMLTTITERGRVKCHQYWPRVFE-TQEYGR----LMIKC--IKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRkarq
.||  . | ...||.|||| .   .. .|     . ..   .|     . .    ...   ... | ....|.  |||.|||.     | ... ||    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....

GSVDPIVVHCSAGIGRTGVLILMET-AACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.  .|.|||||||.||.| .. .      ...  .     ..|. .|.||   |||  || ..   .| 
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
0045450 (Phosphotyrosine protein) phosphatases II 752-1011 5.6e-84 277.7 In-house 28-303 (307) alignment 
Range on Protein: 752-1011
Range on HMM: 28-303/307.0
KVVDHFEMLYRKKP--GMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS----GDYINANYVNMEI----PSSGIVNRYIACQGPLAHTSSDFWVMV
..  .||.|.. ..   ....| .| .|  ||||.|. |||.||| |.  ..    .|||||.||.. .    ..  . ...||.|||| .|  ||| |.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDR-NSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKA
|||..|.|||||. .|.||.||.||||   |...||.. ..... ..  ....| . . |   ..|.|.||...|..|||||||........|..|||||
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

RQG--SVDPIVVHCSAGIGRTGVLILMETAACLVESNEP---VYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
..   .  |..||||||.||||..|.. .. ...|...    | .|..|...|.||   .|.|.|| |..| .|  
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 752-1012 1.7e-56 186.3 In-house 21-283 (290) alignment 
Range on Protein: 752-1012
Range on HMM: 21-283/290.0
KVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS-GD----YINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHC
.  ..|.||   .   ....   . |  .||.... .||| |.||.  ..  |    |||| |..    .    ..||| |||. .|  ||| ..|....
gfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek....kqyiatqgpvsntlvdFWkliwqekv

TTIVMLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNS-SEERRVTQMQYIAWPDHG-VPDDPKHFIQFVDEVRKARQGS
| |||||.|.| |.|||.||||   .|..||   || ........   |.......||  ... ||| |  .|...| |..     ...   ... |.  
tiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

VDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
  .||||||...||..|.. ..|.   ....  .  .......| |.  ..||  || .... .|.. 
ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
0045098 (Phosphotyrosine protein) phosphatases II 754-1012 4.8e-77 254.3 In-house 10-272 (278) alignment 
Range on Protein: 754-1012
Range on HMM: 10-272/278.0
VDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTlqaspsgDYINANYVNMEiPssgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLT
   || |..  .  ...   .  ||.||||.|. ||| .||        |||||.|...  |     ...||.|||| .| .||| |.||...|.|||||
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivmlt

TITERGRVKCHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDR----NSSEERRVTQMQYIAWPDHGVPDDP--KHFIQFVDEVRKARQ-----
. .|.||.||.||||   ....||.. ..... ... . ..| . ...     .. |.| ||...|. |||||||..|  |.|.......|.|..     
elvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------GSvDPIVVHCSAGIGRTGVLILMETAACLVesNEPVYPLDIVRTMRDQRAM-LIQTPGQYTFVCESILRAY
         ..  |..||||||.||||.|... .  .|.  .. | .|..|...| || .  .|...|| |..| .|. .
llsslllldsg.gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 754-1014 1.9e-76 252.2 In-house 23-282 (318) alignment 
Range on Protein: 754-1014
Range on HMM: 23-282/318.0
VDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIV
   .|.| |..  ..       .| ||||| .. .||.||| ||    ... |||||||..         . |||.|.||..| .||| |||||....||
seeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy....rrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKAR-QGSVDPIV
||| ..|||..|.|.|||   ....||.|...  .......   |||... ....|.| | | .| .|||.|||... .....| .|.||  . ...|||
mltqeeergkakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpiv

VHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHD
||||||.||||| | ...    .. .. |  ...|...|.|| ...||  ||.|. . .| | . 
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0046845 (Phosphotyrosine protein) phosphatases II 755-1012 7.4e-88 289.9 In-house 4-274 (284) alignment 
Range on Protein: 755-1012
Range on HMM: 4-274/284.0
DHFEMLYRKKPGM--SMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS----GDYINANYVNME-IPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCT
. ||.|.. .. .  |.....| .|| ||||.|. |||..|| |.  ..    .|||||.||..  .. . | ...||.|||| .|  ||| |||||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GS
.|||||...|.||.||.||||   |...||........ ..  ....|...... . ..|.|.||...|..|||||||..|.....|...||....  ..
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

VDPIVVHCSAGIGRTGVLILMETAACLVESNE---PVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
  |||||||||.||||..|..... ...| ..    | .|..|. .|.|| . .||. || ||.| .| ..
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
DSPc_SM00195 755-1011 1.2e-82 272.6 In-house 4-261 (263) alignment 
Range on Protein: 755-1011
Range on HMM: 4-261/263.0
DHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVM
 .|| | ....  ...  .  .| .||||... |||.||| |. ..   . |||||||....       ..|||.|||| .| .||| ||||.....|||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTT-NCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIV
||   |.|. ||..|||.   .....|.. .|... ...  ..  |.....  . .|.|.|||.|| .||||||||..|...... .|.| .. |  |||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||||.||||........   .|... |   .||. .|.||....||  ||.|..| ||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 755-1011 1.2e-82 272.6 In-house 4-261 (263) alignment 
Range on Protein: 755-1011
Range on HMM: 4-261/263.0
DHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVM
 .|| | ....  ...  .  .| .||||... |||.||| |. ..   . |||||||....       ..|||.|||| .| .||| ||||.....|||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTT-NCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIV
||   |.|. ||..|||.   .....|.. .|... ...  ..  |.....  . .|.|.|||.|| .||||||||..|...... .|.| .. |  |||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||||.||||........   .|... |   .||. .|.||....||  ||.|..| ||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN9_pd Subfamily PTPN9 755-1009 8.3e-67 220.3 In-house 20-287 (297) alignment 
Range on Protein: 755-1009
Range on HMM: 20-287/297.0
DHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVM
 ... . ....   ..  .| ||| |||| ||  ||.|||.|.     .  ||||||.|.         . .|| |||| .|.|||| |||||.. .|||
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy....kqkkafiatqGplkktvsdfWrmvWeqevlvivm

LTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV-----
 | . ||||.|| ||||    ...|.| | .. ...... .   | . |.. . .|.|.||  |...|||.|||.. . .......||...  .|     
ttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

--------DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
         |||||||||||||| .| .. .   .|. . |   . |...| |||  |||| ||.|   ..|
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 755-1013 5.5e-47 155.2 In-house 24-280 (439) alignment 
Range on Protein: 755-1013
Range on HMM: 24-280/439.0
DHFEMLYRKKPGMSMNIC--RLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHCTTI
. ||..   .|  . . .      . .||||.|| ..| ||||||     |   ||||||..         . |||.|||  .|. ||| .|.|....||
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd....klyiatqgpkkettddfwrlviekktvti

VMLTTITERGRvkchqYWPRVFETqEYGRLMIKCIKDKQTTNCCYREFSI---RDRnSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ-GSV
|||| . |  .     |||   |.  || ..... .. .  | . | | .   ||. .  || | |..||||||. || .  | ..|.  .  | .   .
vmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdt.tekertvlqfhyiawpdknvpaqashvldflrainsandkeey

DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
 |.|||||||.|||| .| .. |   . ... |    ||. .|.||  ..|.  || |. ...|    
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_PTPRD_pd Subfamily PTPRD 756-1013 1.2e-85 283.3 In-house 28-282 (564) alignment 
Range on Protein: 756-1013
Range on HMM: 28-282/564.0
HFEMLYRKkPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVML
 .. . .. . .... ..  || ||||| ....|| .|| |.   . .. |||||....    .    . ||| |||||.| .||| |||||...|||||
eykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

TTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHC
| . |.|.||||.|||   .|..||.|...  . .. .. . |.|.... .||| | |.| ....|||||||. ..........||....    ||||||
tkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC

SAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
|||.||||. | ..     ..... |    .|...| || ...||. || |. | || | .
SaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_PTPRN_pd Subfamily PTPRN 756-1008 5.9e-50 164.7 In-house 34-288 (297) alignment 
Range on Protein: 756-1008
Range on HMM: 34-288/297.0
HFEML--YRKKPgMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEIPSSgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIV
..| |  |. .|  . ....   |. |||...| |||..||.|...    . |||||  .  . | .     |||.|||||.| .||| ||||| .. ||
ewealcayeaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra...payiatqgplastvadfwqmvweqGvvviv

MLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQT-TNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIV
.||...| |  .|..|||    .. |.   .. . ..    .   | | ... ..|| | |||. ...||..|||  .| ...|   | |. .|   |||
nltrleeegvkqckrywpde.GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpiv

VHCSAGIGRTGVLILMETAacLVESNEPVYPLDIVRT---MRDQRAMLIQTPGQYTFVCESI
||||.| ||||| ||..    |   .  |  .||. |   .||||. |..|  |. |.  ..
vhcsdGaGrtGvyilidlv..lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_CG7180_pd Subfamily CG7180 756-1012 1.6e-44 146.7 In-house 18-290 (296) alignment 
Range on Protein: 756-1012
Range on HMM: 18-290/296.0
HFEMLYRKKPGMSMNICRLT---ANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTI
 ....... | .... |.      |. |||. .| ||| .|| |.      . ||||| ||.    |    . ||  ..|  .|  .|| .|..... ..
eyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisav

VMLTTITERGRvKCHQYWPRVFeTQEYGRLMIKCIKDKQTTNCCYREFSIRDR----------NSSEERRVTQMQYIAWPD-HGVPDDPKHFIQFVDEVR
|.||  ..  . ....|||     ..|| .... .. || .|   |.| .  .           . |.| |...|.  |.  . ||   . .|...  ||
vvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr

KARQGS-----VDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
. |.         |.||..| | .|.|| . .. .  ||| .| |   . |.|.| .|  |...  .| .. . .| |.
lwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 756-935 4.8e-40 132.3 In-house 12-191 (297) alignment 
Range on Protein: 756-935
Range on HMM: 12-191/297.0
HFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP-SGDYINANYVNMeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTT
. ..|.... | |.  ..  . | ||||||.  .||||| |. ..   |||||.|| .  |      .||  ||||  |  ||| .|.||   .|||.. 
ekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

ITERGRVKCHQYWPRVF-ETQEYGRLMIKCIKDKQ--TTNCCYREFSIRDRnsSEERRVTQMQYIAWPDHGVPDDPKHFIQFVD
. | || ||  |||.|  | .. | .... . .      .    |. .  |  ||.| |. .|...||||||| | .   .|  
lqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_eak_pd Subfamily eak 760-932 7.4e-14 45.9 In-house 35-202 (332) alignment 
Range on Protein: 760-932
Range on HMM: 35-202/332.0
LYRKKPGMSMNICRLTANLAKNrYRDVCPYDDTRVTLQASPS--GDYINANYvnMEIPSsgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITE
| .... .|..  . . .. .|   .. |||   | | .|      ||||    .| .   . ..||    .       || || ||.  .||.|    |
lddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasl..aefse..vGrkyiltGiasedkvfafwqmvleqkspaivqlledve

RGRVKCHQYWPRVF-ETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNssEERRVTQMQYIAWPDHGVPDDpKHFIQ
 .  |  .|.|    |  ..| | ... .  .  .  .| . ..  |  |  ||   ..  | .  .|   . |. 
lkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpky.edfla
subfamily_PTPN12_pd Subfamily PTPN12 761-1010 1.9e-68 225.5 In-house 24-275 (290) alignment 
Range on Protein: 761-1010
Range on HMM: 24-275/290.0
YRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMeipsSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITE
|...  .| .  . . | .||||.|. ||| .||.|.        ||||||...     .    .||| ||||..| .||| |.||.. . .||.  . |
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg....vegkleyiaaqgPLpktlddfWrmiweknveivvmaCreve

RGRVKCHQYWPRVFETQE-YGRLMIKCIKDKQTT-NCCYREFSIRDRnsSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAG
 |. ||..|||   |..  .| . ......|... .   | . .. .  .|.|.|.|..| ||||||||  .|. ......||. .. .  |.|||||||
lgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG

IGRTGVLILMETAACLVESNEP---VYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.||||..| .. .  |....     .   |.|...| ||| |.||  ||..| .... 
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 762-1010 8.1e-56 184.6 In-house 46-289 (319) alignment 
Range on Protein: 762-1010
Range on HMM: 46-289/319.0
RKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTtiter
.  ..  .. . |  |  |||. .. ..| ..| |.        ||||| .|.         ..|||.||||  |  ||| |.||..|.|||.||     
lgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....

gRVKCHQYWPRVFEtQEYGRLMIKCIKDKQTTNCCYREFSIRD-RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GSVDPIVVHCSAG
 . || ||||   . ....|  .|    ..| .   |.. . .  .  . |..||  .  |||.|||| |  ....|. ||. ..      .||||||||
.kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.||||| | ...    .. .. |   ..|| .|.||  |.|   || |.  ..| 
vGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 763-1011 4.3e-55 182.2 In-house 11-254 (284) alignment 
Range on Protein: 763-1011
Range on HMM: 11-254/284.0
KKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTtiterg
  .|  .. . |  |  |||. .. ..| ..| |.        ||||| ...         ..|||.||||  |  ||| |.||..|.|||.||      
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......

RVKCHQYWPRVFEtQEYGRLMIKCIKDKQTTNCCYREFSIRD-RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GSVDPIVVHCSAGI
. || ||||   . ....|  .|    ... .   |.. . .  .  . |...|. .  |||.|||| | .....|. ||. ..      .||||||||.
kdkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

GRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||| | ...    .. .. |   ..|| .|.||  |.|   || |.  ..|  
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 763-1016 1.8e-49 163.6 In-house 34-292 (325) alignment 
Range on Protein: 763-1016
Range on HMM: 34-292/325.0
KKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMV--WEqhCTtIVMLTTITE
 . |.....  . .| ||||...| ..| .|| |   . .|| |||||.|.. ..      . ..|.| ||..|  |.| .|  |.  |. .|... . .
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk....dvflaaqaPltatindlWrlvldWr..cs.vvvvlneld

RGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQ---FVDEVR---KARQGSVDPIVV
 |  .| .|||.   .....| | .| .  .. ..  .| . ... .  | | | |.|. .|.| ||.  |  .|     |..|    .|   .  ||.|
lgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGT
|||||.|||||.| . .|.  |  .  |  .. |. .| .|  ...|  ||... |..  ||  | 
hcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 764-1011 1.8e-51 169.8 In-house 36-277 (287) alignment 
Range on Protein: 764-1011
Range on HMM: 36-277/287.0
KPGMSMNICrlTANLAKNRYRDVCPYDDTRVTLQaSPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKC
.  . .||   . |  |||.... ..|. || |.     ||||| ...    .    ...|....|...|  .|| ...... |.||||.  .|  . .|
edevthnia..sqnkdknRltqilvpdnyrvllk.gehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevc

HQYWPRVFEtQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-SSEERRVTQMQYIAWPDHG-VPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGV
.||||       .|   |. .........  |.. .. .| ......|.| |. .|...| |..    .... . ... |. .  .||||||...||...
yqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsam

LILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
.. ..|.   .. .  .  ..... .| |.   .||  ||.|... .|  
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
0049772 (Phosphotyrosine protein) phosphatases II 764-1005 1.5e-38 128.7 In-house 33-273 (314) alignment 
Range on Protein: 764-1005
Range on HMM: 33-273/314.0
KPGMSMNICRLTANLAKNRYRDVCPYDdTRVTLQASPS--GDYINANYVNMEipssgivNRYIACQGPLAHTSSDF----------WVMV--WEQHCTTI
 | ... ...| .|  |||| |..|.| .|| |.  |    |||||.||.         ...||.|||| .|  ||          | ||  ..... .|
lpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------LTTITERGrvkcHQYWPRVFETQEygrlmikcikdkqttnccyrefSIRDRNSSEERRVTQMQYIAWPDHGVPdDPK
||                     |......|     ..... .|. .                      .. . ..  ||.. .  .| .||...| ...
vmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk......................eelydpelferlgikylripvpDgsap.lle

HFIQFVDEVRKArqGSVDPIVVHCSAGIGRTGV-LIlmetAACLVESNePVYPLDIVRTMRDQRA-----MLIQTPGQYTFVC
.| .|.. ...|      |..|||.||.||||. ..    ||.|.  .  | . .... .| .|       .|... || |. 
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvv....aaylmkll.gvsleealedvrlkRpinpnpgfieqleqyefil
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 765-1012 6.9e-66 217.5 In-house 44-290 (298) alignment 
Range on Protein: 765-1012
Range on HMM: 44-290/298.0
PGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNMEIPSSgivnRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRV
.  .... | ..|  |||| |. ..| .|| |..      .||||| ...    ..     .||.|.|| .| .||| ||.|.. .||||||...| ...
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn....afiatqaPltetvedFWrmvteedigtiVmltnleeldkt

KCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV-DPIVVHCSAGIGRTG
|.|.||| . ....||.. ..  .... ..   |.. . ......||.| |.... |||.|||   .  ......||. .| .   |..|.||||.||.|
kyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsG

VLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
  | ...    |. .. |  ...|...| .|. ..||  ||.|. | .|.| 
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 765-1010 4.1e-50 165.1 In-house 42-281 (290) alignment 
Range on Protein: 765-1010
Range on HMM: 42-281/290.0
PGMSMN--ICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNmeipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVK
|.  ..  |    ... ||||.||   | ||| |.    |||. ||||.      |.   .|  ||.|. |  |.| || ... ..||||  . | |. |
pvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkak

CHQYWPRV-FETQEYGRLMIKCIKD-KQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARqGsvdPIVVHCSAGIGRTG
|.||.|    |.  .| . . | .. .. .|   . .|.||..|  | ..  .. ..|||. |.     ... .  .|||  |   |.||||||||||||
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas.G...pvvvhcsaGiGrtG

VLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
 .. .|... ..     . .||.||..|. |.  .|   ||  . | .| 
tfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 765-1010 2.1e-49 162.9 In-house 21-264 (283) alignment 
Range on Protein: 765-1010
Range on HMM: 21-264/283.0
PGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNMEIpSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCH
| .. .|     |  |||.... |.|  || |.. .  ||||| .. ..  |    ..||..|.|| .|  ||| ||.... |.||||| . |  |.|| 
pdldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsk.sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSE-ERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLI
||||.   ...|| . .   |.        .|. .|  .|.. .  ..  |.| | . |       ...|   . . ..    |||||||.|||||.|.|
qyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

LMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
 . ..   . ..  |    .|. || || |..|| .|| .| | .| 
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN23_pd Subfamily PTPN23 767-1013 7e-66 217.0 In-house 35-281 (288) alignment 
Range on Protein: 767-1013
Range on HMM: 35-281/288.0
MSMNICRLtaNLAKNRYRDVCPYDDTRVTLQaSPSGDYINANYVNMEIPSSgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
.|. | .|  .  |||.||. ||| .||.|. .   ||||| .|.   | .     .|| |.||. |..||| ||.||.  .||||.. .|.|. |...|
rsiaiakl..yseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgc...PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrY

WPRV-FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRK----ARQGSVDPIVVHCSAGIGRTGV
||    ||...| | . . . ..| ..  |..... ..... . |. .|. .||..|||. |....||.|||..     .. |  |.|||||||.|||||
wPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

LILMETAACLVESNEPVYP-LDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
. |. .|.  .| .. .   ...|...| ||   .|.  |. |. | .|.| .
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_PTPN1_pd Subfamily PTPN1 767-1010 4.5e-65 214.2 In-house 22-269 (290) alignment 
Range on Protein: 767-1010
Range on HMM: 22-269/290.0
MSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNMEIpssgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
.... ..| .| ..|||||| ||| .|..|. .   |||||. |..|     .  .||  ||||..| . || |||||.. ..|||  . |....||.||
fptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvelee....akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPRVFETQ----EYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GSVDPIVVHCSAGIGRTG
||.  |..    |  .| .| |. ... .   | . . .... | | .... |..||| |||. |  |..|. .||..      | | |.||||||||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VLILMETAACLVESNEPVYPLDIVR---TMRDQRAMLIQTPGQYTFVCESILR
 ..|..|   |.| .. .  .|| .    .| .|  ||||. |  |   .|| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPRG_pd Subfamily PTPRG 767-1011 5.7e-63 208.0 In-house 37-286 (563) alignment 
Range on Protein: 767-1011
Range on HMM: 37-286/563.0
MSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS--G--DYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVK
. ..  . . |  |||| .. .|| .||.|.  |   .  |||||||..         . .|| ||||..|  ||| |.|||. ..|||.| ..|||| |
ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrk

CHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRD---RNS---SEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGI
|..|||.  |...|| | .. |. ....    |...|..   ..     .|..|.| .|  |||||||. .   ..||    .|..  . |||||||||.
cdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGv

GRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||..| ..|    ..... |  .......| || .|.||  ||.|. . .| |
grtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 767-828 1.5e-08 28.7 In-house 38-95 (95) alignment 
Range on Protein: 767-828
Range on HMM: 38-95/95.0
MSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEipssGIVNRYIACQG
 .  .    ||. |||. .. ||| |||.| .    ||||| .|.         | |||.||
apytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy....arkncyiaaqg
subfamily_PTPRA_pd Subfamily PTPRA 768-1015 1.9e-64 212.7 In-house 49-298 (330) alignment 
Range on Protein: 768-1015
Range on HMM: 49-298/330.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCH
.....    |  |||. .. ||| .|| |.     .. ||||| ...         ...||.|||...|  ||| |.|||. .|||||| . || . ||.
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca

QYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIR----DRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTG
||||    .  || . ..  ... . .   |.| ..     ..  ..| |.|. . .||| ||| .|.  .... .|.| .| | .|||||||||.||||
qywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

VLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDG
 .| ...    |.... |   ..|. .| ||. ..||  ||.|. . .|  |  |
tfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 768-1013 2.5e-53 176.0 In-house 40-280 (315) alignment 
Range on Protein: 768-1013
Range on HMM: 40-280/315.0
SMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCH
 ... . . |  |||| .. .|| .|| |   .  |  ||.|||.    |.     .||||.|||.. .  ||| .|.|.....||||| . |. . |. 
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanf....idGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

QYWPRVfeTQEYGRLMIKCIKDKQTTNCCYREFSIRDRnsSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLIL
.|||       ||.. .  ..... |. . | .|.  .  .. | | |..| .||| |||     .....  |.. .. || .||||||||.|||| .| 
kywpdk..kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfit

METAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
...    .| .. .   .... .|..|  ..|.  || |. . .| .. 
ldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 768-1005 9.5e-37 121.2 In-house 43-283 (310) alignment 
Range on Protein: 768-1005
Range on HMM: 43-283/310.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQ--ASPSGDYINANYVNMEIpssgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
|.     . .. |||| ||   |..|| |.   |  .||| ||||. .     . . .| .|||| ||  ||| |.... . .|..|  ..| || ||  
sltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny....lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvg

YWPRVFETQEYGRLMIKCIKDK-QTTNCCYREFSI-RDR-------NSSEERRVTQMQYIAWPDHGVPDDPKHFIQfvdeVRKARQGSVDPIVVHCSAGI
||| .  |. || . .  . .  .  . |    ..  |           .| ||. ...  ||| ||||.  | .      |   |    | |||||||.
ywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagk

GRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVC
.|..|.. .. .   ..  . |   ...  .. .||. |||. ||... 
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_egg_pd Subfamily egg 768-1014 1.8e-29 97.4 In-house 31-272 (307) alignment 
Range on Protein: 768-1014
Range on HMM: 31-272/307.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrVKCH
|.. .    || | | . |   | .||.|.      ..|.| ||.|.       ..| .| .| ||  |  ||| ||.....  |||||.  |    .|.
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPRVF-ETQEY--GRLMIKCIKDKQTTNCCYREFSIRDRNS-SEERRVTQMQYiAWPDHGvpdDpkhFIQFVDEVRKARQGSvDPIVVHCSAGIGRTG
 |||.   ..  .  | | |...| .....  .|   ..   .  ||| .   |.  .   .   |       .  .||.|. |  |.||..  |. ...
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss...d...vysplrvlrklrnls.kpvvvqdilGvskaa

VLILMETAACLVESNePVYPLDIVRT---MRDQRAMLIQTPGQYTFVCESILRAYHD
.|. .|.| . .    |..   . |.   .| .| . .... .| ||   .|  ..|
tlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 768-1007 3.2e-22 73.5 In-house 38-274 (303) alignment 
Range on Protein: 768-1007
Range on HMM: 38-274/303.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQASpsgDYINANYVNMEIPssgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYW
|.   ..  |. |||. ||   | ..| |  |    || |.|....       .. |  | ||.||..||| |. ||.   ...| | .|  ..  .  .
svsknqfvknmdknrfvdvicldhskvklsds...syihasyleldss.....kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

PRVFETQEYGRLMIKCIKDKQTTNCCYREF-SIRDRNSSEERRVTQMQYIAWPDHGVPDD--PKHFI---QFVDEVRKARqgSVDPIVVHCSAGIGRTGV
||  .  ..   .|.  . |.        .  .   | .    .   .| |||   .| |  ||      |    .||       | |    .| ||.| 
prnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys..dstptvymslsgcgragt

LILMETAACLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFVCES
. |.|||   . |...   |   . ..|. |   .|   |...|   
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl
0040439 (Phosphotyrosine protein) phosphatases II 769-1010 3.3e-75 248.2 In-house 3-244 (249) alignment 
Range on Protein: 769-1010
Range on HMM: 3-244/249.0
MNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
.....| .|. ||||.|. ||| .|| |.  |.   .|||||.|.    . . | .|.||.|||| .| .||| |.||...|.|||||. .|.||.||.|
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaq

YWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG--SVDPIVVHCSAGIGRTGVLI
|||   ...|||........ ..  ... |.. . .   .|.|.|...||. |||||||........|...||||..   .  |..||||||.||||..|
ywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

LMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.. .. ...| .  | ....|...|.|| . .|.|.|| |..| .|.
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 769-1008 1.7e-72 239.2 In-house 2-238 (243) alignment 
Range on Protein: 769-1008
Range on HMM: 2-238/243.0
MNICRLTANLAKNRYRDVCPYDDTRVTLqasPSGDYINANYVNMEiPssgivnRYIACQGPLAHTSSD----FWVMVWEQHCTTIVMLTTITERGRVKCH
..|..| .|| ||||.|. |||..|| |   ...||||||....  |      |.||.|||| .|  |    || |.||...|.|||||. .|.||.||.
fsiallpenlsknrysdilpydhsrvkl...egsdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPrvfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG---------SvDPIVVHCSA
||||   ....||........ ... ....|.....  . . ..| |.. .|..||||||||.|.....|.||||.  .          .  |..|||||
qywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsa

GIGRTGVLILMETAACLVesnePVYPLDIVRTMRDQRAM-LIQTPGQYTFVCESI
|.||||.||.. .   |.     | ....|...|.|| .  .|||.|| |. | .
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 769-1013 3.1e-61 201.9 In-house 36-278 (315) alignment 
Range on Protein: 769-1013
Range on HMM: 36-278/315.0
MNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
 ...| | |  ||||... |.| .|| |   . ||  ||||| |    |.|    . ||| ||||  . .||| ||.... |||||.|   |  ..|| |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPR-VFETQEYGRLMIKCIKDKQTTNCCYREFsiRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLIL
|||    .. |.| . .. .. ...|.   |..    |.| | |.||| |.  |||.||. .   ..... ||.  ..    ...||||||.|||||.| 
ywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

METAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
..     .. .. |  ...|...|..|  |.||  .|.|. ...|   .
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 769-1013 4.7e-40 132.2 In-house 40-288 (305) alignment 
Range on Protein: 769-1013
Range on HMM: 40-288/305.0
MNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMeiPSSgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP
|.  . . .  ||||.||   |. || |...   .|| ||||    |.    .|.| .| || .| .||| | ....  .| ||  . |.|  ||..|..
mkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..ptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfa

R----VFETQEYGR-LMIKCI-----KDKQTTNCCYR--EFSIrDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqgSVDPIVVHCSAGI
     |.| .| |. ...|.      | .. ..   .  .. | .   .. |.||.  .| ||| |||      .... . |     |  ||||||||||
skdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvi.egpgekarkvthyhwidwpdrgvpaadlailellekarp....skgpivvhcsagi

GRTGVLILMETAA-CLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
|||| ....|     |.. .       |.. .|.||   |||  || || . ||  ..
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0042113 (Phosphotyrosine protein) phosphatases II 770-1009 3.7e-76 251.1 In-house 2-240 (245) alignment 
Range on Protein: 770-1009
Range on HMM: 2-240/245.0
NICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
....| .|  ||||.|. |||.||| |.  ..    |||||.||    . . | ...||.||||..|  ||| |.||...|||||||. .|.|||||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ-GSVDPIVVHCSAGIGRTGVLILM
||   |...||........ ..  ... |.... .  ..|.| |....|. ||||||||.......|...||||.. .|  |..||||||.||||..|..
wpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
 ......|..  | . ..|. .|.|| . .|||.|| |. | .|
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 770-1009 1.2e-60 199.8 In-house 13-261 (270) alignment 
Range on Protein: 770-1009
Range on HMM: 13-261/270.0
NICRLTANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
..   . . . |||.|. |   |||.|.     .   |||||||.     .|  ..||| .|||. | ..|| |.||.. |.|||.| ..|.|| || .|
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPRVFET-QEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPK------HFIQFVDEVRKARQGS--VDPIVVHCSAGIG
||   ..  ..   .|| .. ... .  |.   .| ....||||..  .| .||||||| ..       . .. . .||. ..     .|..||||||.|
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|||.||....| .|.|... | .| |.. .| .|  |.|.| ||.|. ....
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 770-1009 6.8e-60 197.5 In-house 21-265 (274) alignment 
Range on Protein: 770-1009
Range on HMM: 21-265/274.0
NICRLTANLAKNRYRDVCPYDDTRVTLQ----ASPSGDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
.  ... .  ||||... | . .||.|.     ..  .||||||.      ..  . |.| ||||..| .||| |....... ||||| ..|. . ||..
eeldvfgsqtknryktilPnensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPRVFET---QEYGRLMIKCIKDKQTTNCCYREFSIRDRNSseERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG---SVDPIVVHCSAGIGRT
|.|   ..   ..|| . ||  | ... .   |.....  ..  ||.|. . | .|||| .|||.......|.||...|.     . |.|||||||||||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|. | .. |   .. .. |  | ||  .| .|  ..||  || .. . . 
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 770-1012 2.6e-58 192.2 In-house 2-242 (250) alignment 
Range on Protein: 770-1012
Range on HMM: 2-242/250.0
NICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEipsSGIvNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVkCHQY
....  .|. |||| |. ..| .|| |. .      ||||| ...     ..  . .|| |||| .|  ||| ||.|.. .||||||...| ... .|||
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgy...der.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPrVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG-SVDPIVVHCSAGIGRTGVLILM
|| | ....|| ....  .... ..   |.. .  .. ..|| | |.....||| |||.  .  ......|.. .|     |..|.||||.||.|  | .
wP.vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
..    .. .. |   ......| .|   ...  || || | ||.| 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 770-1010 7.3e-43 141.4 In-house 38-234 (392) alignment 
Range on Protein: 770-1010
Range on HMM: 38-234/392.0
NICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGrvkchqy
....   || ||||... ||| .|| |   . .|  ||.|| |    |||    . |||.||| | . .||| ||.... |||.|.| . |         
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

wprvfetqeygrlmikcikdkqttnccyrefsirdrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVrKARQGSVD-PIVVHCSAGIGRTGVLILM
                                    .  . | |.| ..  |||..||     ...|. || ||  |.   |...|||||.|||||.| .
....................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisi

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
..  .  .    |  ...|  .| .| ...||  ||.|.  ..| 
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 771-1009 1.4e-31 104.6 In-house 37-268 (288) alignment 
Range on Protein: 771-1009
Range on HMM: 37-268/288.0
ICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV
|    || ...||...   | ||| |.  |   ||.|| |     |.   .| | .| ||  |   .| |. |.    ||||. . |.|. |  .|.| .
idsfianptrdryenlprcditrvklsddpd.fyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

F-ETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERR-VTQMQYIAWPDHGVPDDPKHFIQFVDEVrkarQGSVDPIVVHCSAGIGRTGVLILMETA
  |.  .|||     |...  .   .   .|  .  ||.  | .. .  |.|.|||.. . ...... .    .    |||||.|||.|||| |||.  |
lGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililia

ACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.  . ... .    ..  .|..|   |||  || .|   .|
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_PTPRK_pd Subfamily PTPRK 772-1014 2.4e-64 212.2 In-house 38-279 (314) alignment 
Range on Protein: 772-1014
Range on HMM: 38-279/314.0
CRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP
..   | .|||. |. .|| .||.|..    || |||||...     |    . .|. |||| .|  ||| .|....|..||||| ..| ||||| .|||
akkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP

RvfETQEYGRLMIKCIKDKQTTNCCYREFSIRD--RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILME
   .|. || . ..... .  ..   | |...   |. .| | | |.|...||||.||   . ....| .| | .. .  .|||||||| ||||. | ..
e..dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

TAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHD
.   ..| .. |    .|.|.|...  ...|  ||.|. . || |   
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 773-1008 1.7e-31 103.9 In-house 33-265 (281) alignment 
Range on Protein: 773-1008
Range on HMM: 33-265/281.0
RLTANLAKNRYRDVCPYDDTRVTLQA----SPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP
    |  |||| ..   | .|| |.       | ||| |||.     |  .   ||  |||   | .||| |.|..  |.||||  ..|  | || .|.|
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir....spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

RVFET-QEYGRLMIKciKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFvdeVRKARQGSVdPIVVHCSAGIGRTGVLILMET
|      .. .| ..   .  | |       .      | | .|.  .  |||  ||.  . ...    .|| |  |  | |.|||||.||.| |. .| 
rnahcclqfdklsvs..yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlki...lrkirarst.ppvihcsagvgrsgtlmavei

AACLVESNEPVYPL-DIVRTMR-DQRAMLIQTPGQYTFVCESI
|   . |   .  . .||  .|   ||  .||  || .. . .
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 773-811 2e-06 21.6 In-house 35-75 (244) alignment 
Range on Protein: 773-811
Range on HMM: 35-75/244.0
RLTANLAKNRYRDVCPYDDTRVTLQASP--SGDYINANYVN
 |.|| .|||| .. |.|.||| | .|   . |||||||..
vlsanatknryinilpfdetrvilssskkegsdyinanyiq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 774-1013 1.7e-53 176.3 In-house 35-278 (287) alignment 
Range on Protein: 774-1013
Range on HMM: 35-278/287.0
LTANLAKNRYRDVCPYDDTRVTLQASPS--GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF
 .|.  |||| || |.||||| | | .    ||||||||    .|    ...||.|||.| |  ||| .|.|.. ......|   | .| ||..|||   
elaavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

ETQEYGRLMIKCI-KDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEV----RKARQGS-VDPIVVHCSAGIGRTGVLILM
     |   .  . .|..  . . | . . | .. | | | |.....|||....     .|.|| .|      ||..| | |.|||...||||.|.|. .
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
 .     |.   | .  .|  .| .|| |.|.. |. ...|..   |.
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 774-1007 9.5e-35 114.9 In-house 32-265 (285) alignment 
Range on Protein: 774-1007
Range on HMM: 32-265/285.0
LTANLAKNRYRDVCPYDDTRVTLQASpSGDYINANYVNMeiPSSGiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPR-VFE
  ||   ||| ||   ..||| |.     ||| |... |  |     . ||. ||||  | |||| |..... . ..|| |. | |  ||  |.|  . |
yeanpdlnryadvrcieetrvvlknh.drdyihaswmrm..pgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TQEYGRLMIKC--IKDKQTTNCCYREFSIRD--RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQgSVDPIVVHCSAGIGRTGVLILMETA
  ..|.  |     |..  .   .  ... .    |||   . ..|   |||.  |.| . .|..   |.|       ||.||||||.|||  .. .. |
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidya

ACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCES
.  .  |  .  ||||| ||  |   .|.  |. |.   
tirimenpniemldivremramrfqavqshmqflflyvv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 775-1019 8e-57 187.5 In-house 41-284 (515) alignment 
Range on Protein: 775-1019
Range on HMM: 41-284/515.0
TANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPR-V
  |  ||||... ||| .|| |   . .|  ||.|| |    |||    . ||| |||.  . .||| .|.... |||.|.|   |  ..|| .|||   
einfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

FETQEYGRLMIKCIKDKQTTNCCYREFSIRdRNSSeERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAAC
 .. ..| . .. .  .  |.   |.. .  ...   | ||| ..  |||.||| . . ..... ||.  ..    |...|||||.|||||.| ..    
gdsvkfGsikvelvsleactggikrkltvl.kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

LVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH-DGTIKP
 ..  . |  ...|. .|..|  |.||  ||.|. . .|   .   |. |
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlip
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 775-1018 1.8e-30 100.8 In-house 31-264 (267) alignment 
Range on Protein: 775-1018
Range on HMM: 31-264/267.0
TANLAKNRYRDVCPYDDTRVTLQASpSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITErGRVkcHQYW-PRVFET
. | ..||. |..||||||| |. .   .|||| ||.    .    | .|. |.||  | .||. .. .|....||.||.. . . .  ...| |.. ..
eknqernrlddnlpyddtrvilrtk.eeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dni..rlfwPPkmgqa

QEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEeRRVTQMQYIAWPDHgVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVE
..|  | ..   .|.  .     . .. .| |  . ||   |  |    . . |     |    ..  .    |.||.||.|.||.| .. ...    . 
kkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnin.tnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

SNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESiLRAYHDGTIK
 .. .   | .| .|.||  |..|  .| .. |. |  | .| .|
tegvsdifdflrkirsqriglvdtkeryiyihel.laeyaegrlk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 775-852 2.6e-06 21.2 In-house 35-116 (347) alignment 
Range on Protein: 775-852
Range on HMM: 35-116/347.0
TANLAKNRYRDVCPYDDTRVTLQ--------ASPSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVML
  .|.||| .||   |.||| |         | ..  |||| .....  |    . ||  | || .|  ||| ||   . | .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnas....keyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 776-1012 1.8e-55 183.2 In-house 50-284 (297) alignment 
Range on Protein: 776-1012
Range on HMM: 50-284/297.0
ANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRvKCHQYWPRVFE
 |. |.||... |||  ||.|.    .|. ||.|| .|.      |. .|.|. | |   |  |||.||.... .|||||.   || . || .||.    
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk......gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

TQeYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPD--DPKHFIQFVDEVRKARQGSVD-PIVVHCSAGIGRTGVLILMETAA
|. .| . ..    .. .    ||....  ..  .| | | |.. |||. |.   . . ......||||  ..  . |..|||.||.||||||. ..   
tt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

CLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
. .. .. |  ...|. .|..|  |.||  ||.|| . .| | 
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 776-1010 2.6e-44 146.2 In-house 6-238 (239) alignment 
Range on Protein: 776-1010
Range on HMM: 6-238/239.0
ANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvfE
 | ||||| ..  || .|| |.     |  |||||.|.       |  . ||| || .. .| ||| |.|...   ||||| . |  . |||||||    
vnkaknryanivtydhsrvvleklsndphsdyinasylrd...ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..s

TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLV
| .|  | .   | .  ..   | | . .   .||| | | ..  |||.|||.     . .  .. |       | |.|||||.|||| ......     
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
. .. |  .. |...|..|  ..||  || |.  ..| 
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 776-1009 4.8e-44 145.3 In-house 7-238 (239) alignment 
Range on Protein: 776-1009
Range on HMM: 7-238/239.0
ANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvfE
 | ||||| ..  || .|| |.     |  |||||.|.       |  . ||| || .. .| ||| |.|...   ||||| . |  . |||||||    
vnkaknryanivtydhsrvvleklsndphsdyinasylrd...ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..s

TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLV
| .|  | .   | .  ..   | | . .   .||| | | ..  |||.|||.     . .  .. |       | |.|||||.|||| ......     
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
. .. |  .. |...|..|  ..||  || |.  ..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 776-1010 1.1e-41 137.5 In-house 54-287 (305) alignment 
Range on Protein: 776-1010
Range on HMM: 54-287/305.0
ANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEIPSSgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQE
 . .||||.||   | . | |.  .  ||| ||||   .      .|.|..|||| .|  .|| || ...   ||||    | |..|| ||||     . 
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe...krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

ygRLMIKCI-KDKQTTNCCYR--EFSIRDRNS----SEERRVTQMQYIAWPDHGVPDDPKHFIqfvdEVRKARQGSVDPIVVHCSAGIGRTGVLILMETA
   |   .. ..   ..   |  |  |   |     ...  | ..|.  ||| |||      .    |.  | .||  |||||||||||||| .. .|  
..elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsl....ellsairgskvpivvhcsagigrtgtivaieyi

ACLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFVCESILR
   .  | |. |. ..|...|||||. ||.  || |.   .| 
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_ptpA1_pd Subfamily ptpA1 776-963 1.4e-34 114.5 In-house 46-247 (418) alignment 
Range on Protein: 776-963
Range on HMM: 46-247/418.0
ANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYVNMEIPssgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFE
 | .|||| .. | . ||| |   |     |||||||..   |     ...|. ||||  | .||| ||||..|  ||||.  .|  |.|| .|||    
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.....kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

TQE----------YGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ---GSVD---PIVVHCSAGI
 ..          .|   .. ..  |  .       ||     | | .|| ||  |||| .||  . | |..  . . ..    | |   ||.||||||.
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGVLI
|||| . 
grtgtfc
Y_phosphatase Protein-tyrosine phosphatase 777-1009 1.3e-79 262.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 777-1009
Range on HMM: 1-234/235.0
NLAKNRYRDVCPYDDTRVTLQASPS-GDYINANYVNMEIpSsgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP-RVFETQ
|. ||||.|. |||.||| |. |..  ||||||||..   .    ...||.|||| .| .||| |||......|||||. .|.||.||.|||| .  |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGRLMIKCI-KDK-QTTNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACL
.||.. ...  | | ...... |.......... |.|.|.|..| .|||||||..||........|.| .. .  |.|||||||.||||........ . 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.|..| |  |.||...| ||....|.  || |... ||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 777-1009 1.3e-79 262.3 In-house 1-234 (235) alignment 
Range on Protein: 777-1009
Range on HMM: 1-234/235.0
NLAKNRYRDVCPYDDTRVTLQASPS-GDYINANYVNMEIpSsgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP-RVFETQ
|. ||||.|. |||.||| |. |..  ||||||||..   .    ...||.|||| .| .||| |||......|||||. .|.||.||.|||| .  |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGRLMIKCI-KDK-QTTNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACL
.||.. ...  | | ...... |.......... |.|.|.|..| .|||||||..||........|.| .. .  |.|||||||.||||........ . 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.|..| |  |.||...| ||....|.  || |... ||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 777-1009 2e-51 169.5 In-house 3-236 (237) alignment 
Range on Protein: 777-1009
Range on HMM: 3-236/237.0
NLAKNRYRDVCPYDDTRVTLQASPS-GDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQE
| .|||| ..  || .|| |. . |  |||||.|..      |  ..|||.||||  .  ||| |||...|. ||||| . |. ..|||.|||   . . 
nkiknrygnivaydhsrvvlkgagsgsdyinatylkg...fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGRLMIKCIKDKQTTNCCYREFSIRDRNSSEE-RRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRK-ARQ-GSVDPIVVHCSAGIGRTGVLILMETAACLV
|| | .   |... ..   | . .  | . .| | . | |. .|||.|||.    ...|  .. . ..      | ..|||||.||||.......     
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
. .. |   . | .. ..|  .|||  || |. ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0041856 (Phosphotyrosine protein) phosphatases II 777-1011 2.4e-48 159.5 In-house 1-170 (182) alignment 
Range on Protein: 777-1011
Range on HMM: 1-170/182.0
NLAKNRYRDVCPYDDTRvtlqaspSGDYINANYVNMEIPSSGivnrYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTtitergrvkCHQYWPrvfetqey
|| ||||.|. ||| .|         ||||||.. .  |..     .||.|||| .|  ||. |..|...||||.||         ...|||        
nldknrysdilpydhsr.......dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

grlmikcikdkqttnccyrefsirdrnSSEERRVTQMQYIAWPDHGVPDdPKHFIQFVDEVRKarqgSVDPIVVHCSAGIGRTGVLILMEtaacLVESNE
                           . .|| ..| .|. |||||||| . ....|..||..    .  |..||||||.||||.|...     |.....
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaay....lmkklg

pVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
 | . ..|...| .| . ..|| || |.   .|  
.vsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 777-901 1.9e-24 81.0 In-house 47-184 (350) alignment 
Range on Protein: 777-901
Range on HMM: 47-184/350.0
NLAKNRYRDVCPYDDTRVTLQ-----------ASPSGDYINANYVNMEIPSSGIVN--RYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKC
  |||||... ||. .|| |.           .  . |||||||.... .|  |    .||| |.||  |  ||. .. . . . |..||.  | .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRD
..||..    .   .|  |  .   . ..  . . .. 
yrYWqegsydditvklaskwenimgindsslysadvkk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 777-870 2e-12 41.1 In-house 48-156 (349) alignment 
Range on Protein: 777-870
Range on HMM: 48-156/349.0
NLAKNRYRDVCPYDDTRVTLQASPS-----------------GDYINANYVNMeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERG
  |||||.|. ||. .|| |. |.                   |||||||...  .   . ..||| | ||  |  ||. ..  .    .. |.   | .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkl..trisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

RVKCHQYWPRV
  ||..||   
lekcdiywqel
subfamily_CG42327_pd Subfamily CG42327 779-940 8.2e-28 92.0 In-house 30-193 (319) alignment 
Range on Protein: 779-940
Range on HMM: 30-193/319.0
AKNRYRDVCPYDDTRVTLQASPSG---DYINANYVNMEIPSsgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV---FE
 |.|. .| |  .|||.||  ..     |..|.||     .    | |||.| .|  .||||| .||||   .|| || . | |  .| .|.|      .
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda...pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYiAWPDHGVPDDPKHFIQFVDEVRKA
|. || ...   . .   .     . ..  . .| | .|   |  |.. .|| ... .|  . |||..
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 780-1003 1.1e-35 117.9 In-house 53-272 (301) alignment 
Range on Protein: 780-1003
Range on HMM: 53-272/301.0
KNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFE-TQEYGR
|.||  |    .| | . .      | ||... .    |  .|.|| ||||  || |||.|.   .  .||||.   |.   ||..| |  .. . . ||
khryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

LMIKCIKDKQT--TNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqgSVDPIVVHCSAGIGRTGVLILMETAACLVESN
 .||  . ..    .   |.. ..|     . | ||  ||  |.|.|||    .  .... |.|    | .||||||||||||.  .|  |  |  ||..
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylarevead

EPVYPLDIVRTMRDQRAMLIQTPGQYTF
  .   . .. .|..|   .||  |  .
ptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 780-1011 3.3e-27 90.0 In-house 46-275 (312) alignment 
Range on Protein: 780-1011
Range on HMM: 46-275/312.0
KNRYRDVCPYDDTRVTLqASPSGDYINANYVNMeipsSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV--FETQEYG
 ||| ..  .|  | || |     || ||.|..        .|....||||  |.. || ..    .|.|..|... | |  || .|   .  |   |  
lnrypniqcwdrgrftl.agdenfyihanfvki....ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

RLMIK-C----IKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQgsvdPIVVHCSAGIGRTGVLILMETAACLV
|.  . |    |  |   .  .| . .  . . .| .. . |. .|||||.||      ...  |.| ..    |.. |||||.|||| |.|.|.  . .
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaal

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
         |.   .| .||  ...  || ..  ..|  
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
0044763 (Phosphotyrosine protein) phosphatases II 788-1011 1.4e-35 118.0 In-house 1-170 (178) alignment 
Range on Protein: 788-1011
Range on HMM: 1-170/178.0
PYDDTRVTLQASPS---GDYINANYVNmeiPSsgivnRYIACQGPlahtsSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFEtqeygrlmikci
|.|.||| |.  .    .|||||...    |       |.....|     .|.. ...|...|.||.||. .|.|..||..|||. ..            
pldrtrvllsnleglersdyinaseil...pg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

kdkqttnccyrefsirdrnsseerrvTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLIlmetAACLVESNePVYPLDIV
                           |...| .||||||| ..|| .||. ...|.. .  |..||||||.||.|.|.    || |. ..  . . ...
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlv....aaylmkkl.glsleeai

RTMRDQRAmLIQTPGQYTFVCESILRA
. .| .|   ...|||. ...|  || 
elvrerRp.ivpnpgqlrqLyefelrl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 789-923 2.6e-09 31.5 In-house 5-126 (130) alignment 
Range on Protein: 789-923
Range on HMM: 5-126/130.0
YDDTRVTlqaspSGDYINANYVNMeipsSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrvkcHQYWPRVFETQEYGRLMIKCIKDKQ
.. .|.        .||||..| .    .|  . |.  | ||| || ||| |. |..   .|.| .. |       .|||     . |   .|  . |..
fevsrlq.....gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

TTNC-CYREFSIRDRNSSEERRVTQMQYIAWPDHGV
  .     .. | .      . .| .|   ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 791-1009 2.3e-24 81.0 In-house 32-256 (290) alignment 
Range on Protein: 791-1009
Range on HMM: 32-256/290.0
DTRVTLQAS---PSGDYINANYVNMeipSSGIvnRYIACQGPLAHT-------SSDFWVMVWEQHCTTIVMLTTITERGRV----KCHQYWPRVFE-TQE
.||| |.      . ||| ||.| .   ..|.  | |. | |....         .|| |. . . . .|||   .|. .      | .| |   .    
atrvvLkgygkrfnddyiHAnrvtc...pngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk

YGRLMIKCIKDKQTTNCCYREFSIRDrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqgSVDPIVVHCSAGIGRTGVLILMETAACLVE-S
.. | .|| .  .  .   ||  ..  .  ||  ||  ..  | .  |..|.| ... .. |..    |  |..|||  || |  .|  .. .  ..  .
fkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaet

NEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.. |   |.. ..| |||..|... ...||   |.
sgsvkledvlkalrkqralaitsalelafvdagiv
0043147 (Phosphotyrosine protein) phosphatases II 800-1005 2.6e-43 143.0 In-house 3-154 (172) alignment 
Range on Protein: 800-1005
Range on HMM: 3-154/172.0
PSGDYINANYVNMEIpssgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTItergrvkchqywprvfetqeygrlmikcikdkqttnccyrefsi
.. |||||.|... .    | .|.||.|||| .| .||| |..|...|.||.||.                                             
egsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel............................................

RDRNSSEERRVTQMQYIAWPDHGVPdDPKHFIQFVDEVRK--ARQGSvDPIVVHCSAGIGRTGVLILMETAAclvesnEPVYPLDIVRTMRDQRAMLIQT
    . .|| . | .|. ||||||| .......|.. ...  |.. .  |..||||||.||||.|...          . . ....|...|..| . .|.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

PGQYTFVC
|.|| |..
psqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 801-1011 3e-51 169.9 In-house 3-224 (272) alignment 
Range on Protein: 801-1011
Range on HMM: 3-224/272.0
SGDYINANYVNMEiPSSGIVNRYIACQGPLAHTSSDFWVMvWEQHCTTIVMLTTITERGRVKCHQYWP-----------RVFETQEYGRLMIKCIKDKQT
 ..||||..|..   .  . .|.....||| .|  ||| . .|....|||.|.. .||||.||..|||           ....| .||.|...... ...
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TNCCYREFSIRDR-NSSEERRVTQMQYIAWPDHGVPDDPkhFIQFVDEVRKarqgsVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVY--------P
... .||. ..   . .| |.|....|..|||||||...  ..........       |..||||||..|||.....   .  |. .  |         .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LDIVRTMRDQRAMLIQTPGQYTFVCESILRA
...|. .|.||.  .||..|| |..| .| .
eeaveelraqrpgavqteeqylflyeallel
0046846 (Phosphotyrosine protein) phosphatases II 801-1007 2.1e-45 149.9 In-house 11-168 (176) alignment 
Range on Protein: 801-1007
Range on HMM: 11-168/176.0
SGDYINANYVNMEipssgivnRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEygrlmikcikdkqttnccyrefsir
. ||||||.. .         |.||.|||| .|  ||. |..|...|..|.||. .| ||.||..|||.. . .                          
dldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

drnsseerrvtQMQYIAWPDHGVPDDpKHFIQFVDEVRKARQGSvDPIVVHCSAGIGRTGVLILMEtaacLVESNEPVYPLDIVRTMRDQRA-MLIQTPG
           | ... ||||||||. ..........|.|..    |..|||||||||||.|...     |.|..  . ........|.||  . .|||.
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYTFVCES
|| |. | 
Qyrflyef
0036282 (Phosphotyrosine protein) phosphatases II 802-1005 3.2e-47 155.8 In-house 2-163 (174) alignment 
Range on Protein: 802-1005
Range on HMM: 2-163/174.0
GDYINANYVNMEIPSSgivnRYIACQGPLAhtssdFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvfetqeygrlmikcikdkqttnccyrefsird
 |||||..... . ..    |.||.|||||     || |..|...||.|||..  |.|..||..|||.                                
sdyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

RNSSEERRVTQMQYIAWPDHGVPDDPKhFIQFVDEVRKARQG-SVDPIVVHCSAGIGRTGVLILMETAACLVEsNEPVYPLDIVRTMRDQRAMLIQTPGQ
. ...|| . | .|. ||||||||... ...||..|..|..  .  |..||||||.||||.|...    .. . . .|  ||.||..| || . .|||.|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YTFVC
| |. 
yrfly
0051082 (Phosphotyrosine protein) phosphatases II 802-1005 1.3e-31 104.6 In-house 3-146 (151) alignment 
Range on Protein: 802-1005
Range on HMM: 3-146/151.0
GDYINANYVNmeipssgivNRYIACQGPLAhtssDFWVMVWEQHCTTIVMLTTITERGrvKCHQYWPRVFetqeygrlmikcikdkqttnccyrefsird
 ||||..||          .......||||    ||. ...|....|||.|.. .|||  .|..|.|.                                
sdyinfsyvt.........gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

rnsseeRRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqGSVDPIVVHCSAGIGRTGVLILMETAAcLVesnepVYPLDIVRTMRDQRAMLIQTPGQY
      ..|...... |||.|.|. .. ...|......    .  |..||||||.||||.|...   . |      | . .... .| .| ...|.. |.
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqf

TFVC
 |. 
lfql
0049260 (Phosphotyrosine protein) phosphatases II 818-1005 4.7e-42 138.6 In-house 6-143 (152) alignment 
Range on Protein: 818-1005
Range on HMM: 6-143/152.0
GIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWprvfetqeygrlmikcikdkqttnccyrefsirdrnsseerrvtQMQYIA
.  ...||.|||. .| .||| |..|...|||||||. .|.|..||.||.                                            | ... 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlp

WPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAAclvesnEPVYPLDIVRTMRDQRAMLIQTPGQYTFVC
||||||||.. ....... ..|... .  |..||||||.||||.|...            | ....|. .| .| . ...|||. |. 
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 819-931 5.2e-09 30.1 In-house 135-242 (244) alignment 
Range on Protein: 819-931
Range on HMM: 135-242/244.0
IVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrvkcHQYWPRVFETQEYGRLMIKCIKDKQ-TTNCCYREFSIRDRNSSEERRVTQMQYIA
    ||  | ||| || ||| |. |.|   .|.| .. |       .|||     . |   .   . |..   |    .. |        . .| .|   
rtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisn

WPDHGV-PDDpkHFI
||  |  |.|  |||
wpsdgttpnd..hfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 821-1004 2.6e-17 57.6 In-house 4-195 (198) alignment 
Range on Protein: 821-1004
Range on HMM: 4-195/198.0
NRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMI--KCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIA
 ||||.| || .| .||| ||||     |||.        .    ||| .   | .|| | .  |.|  |     .   ..         | ... |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDDpKHFIQFVD---EVR-KARQGSVDPIVVHCSAGIGRTGVLILMETAA-CLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFV
| ..  |.    |. ||    ||  |  |    |..|||| | | |||.. ..       ||.  |  | .. . .|. |  .| .  .| |.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 821-1004 2.8e-17 57.6 In-house 5-196 (199) alignment 
Range on Protein: 821-1004
Range on HMM: 5-196/199.0
NRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMI--KCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIA
 ||||.| || .| .||| ||||     |||.        .    ||| .   | .|| | .  |.|  |     .   ..         | ... |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDDpKHFIQFVD---EVR-KARQGSVDPIVVHCSAGIGRTGVLILMETAA-CLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFV
| ..  |.    |. ||    ||  |  |    |..|||| | | |||.. ..       ||.  |  | .. . .|. |  .| .  .| |.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 821-871 8.3e-07 22.7 In-house 236-283 (440) alignment 
Range on Protein: 821-871
Range on HMM: 236-283/440.0
NRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrvKCHQYWPRVF
| .|| | ||  |  ||| .| . . .||.||  . ..    |  |||   
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 829-1008 1.3e-17 58.3 In-house 99-284 (302) alignment 
Range on Protein: 829-1008
Range on HMM: 99-284/302.0
PLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP-RVFETQEYGRLMIKCIK---------DKQTTNCCYREFSIRDRNSSEERRVTQMQYIAW
|   |   .| .. . . . .| |... | .  || .|.  .| .. ..||  .| ..         ||.. .    |.    ...  .. |  ... ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPDDPKHFIQFVDEVRkarqGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
|||| |..... .. .             ..||||||.|||| |. .     |   ..    |.||  .|. |   .|.  | ...   .
pdhGapkeaytaldilkfce....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_hpo-7_pd Subfamily hpo-7 830-1009 6.4e-15 49.8 In-house 43-224 (263) alignment 
Range on Protein: 830-1009
Range on HMM: 43-224/263.0
LAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPK
|  |   |. ..  .  ...|||.  .| |..|| .|.|    | | .  . . . | .. .    .|.     .  . . |.. .|  |...  | ...
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

HFIQFVDEVRKARqgsvdPIVVHCSAGIGRTGVLILMETAAC-LV---ESNE--PVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
  .. .. .|. .     ..|||||.||||.    ..|..   ..   .  .   .  | ... .| .|.  |.|| |  |    .|
eilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 833-1009 1e-17 59.1 In-house 40-218 (255) alignment 
Range on Protein: 833-1009
Range on HMM: 40-218/255.0
TSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMIKCIKdkQTTNCCYREFSIRDRNS--SEERRVTQMQYIAWPDHGVPDDPKH
|   |. ..  .  ...|||.  .| |..||..|.|    | . .  . . . |   ...   |   |    .   . . |.  .|  |...  |.... 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FIQFVDEVRKARqgsvdPIVVHCSAGIGRTGVLILMETAAC-LV---ESNE--PVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
  . .  ||...     ..|||||.||||.  ..|.| .   ..   .  |   .  | ... .| .|.  |.|| | .|    .|
ilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 877-1013 6.1e-18 59.3 In-house 62-195 (440) alignment 
Range on Protein: 877-1013
Range on HMM: 62-195/440.0
GRLMIKCIKDKQTTNCCYREFsiRdrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ-GSVDPIVVHCSAGIGRTGVLILMETAACLVESN
 |.|.. .|    ..     .     |. | | . |..| .|||.|||      ......| ....  .  |..|||||| |||||.| ...    .. .
srvmleevkgvpdsdyinasy..i..ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrs

EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
. .  . .. .||..|  ..||| ||.|| |..| .  
dqidifsfinsmrnnrpqmvqtpeqyafvheavlegll
0048076 (Phosphotyrosine protein) phosphatases II 900-1006 1.1e-26 88.6 In-house 37-137 (145) alignment 
Range on Protein: 900-1006
Range on HMM: 37-137/145.0
RDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSvDPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQRAMLIQTPG
 .  . .|| ..| .|. ||||||||.......|.. ...|..    |..||||||.||||.|.    ||.|. ..  | . .... .| || . ...||
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpg

QYTFVCE
|. |..|
qlrflye
0048179 (Phosphotyrosine protein) phosphatases II 902-1006 3.9e-25 83.7 In-house 41-139 (144) alignment 
Range on Protein: 902-1006
Range on HMM: 41-139/144.0
RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSvDPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQRAMLIQTPGQY
 . ..|| ..| ... ||||||||.......|.. ...|.. .  |..||||||.||||.|.    ||.|.  .  . . .... .| .| . ...|||.
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlv....aaylmkklg.lsleealalvrsrrpgavpnpgql

TFVCE
 |..|
rfLle
PTEN_1 903-1002 1.2e-10 36.5 In-house 85-183 (196) alignment 
Range on Protein: 903-1002
Range on HMM: 85-183/196.0
NSSEERRVTQMQ--YIAWPDHGVPDDPKHFIQFVDEVRKARQGS-VDPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQR-AMLIQTP
 . ||..  ...   . ..|||.|.  ..|   ..    ... .    ..||| ||.||.|...    ||.|....    . . .. .|..| .. ...|
ydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppgapnsp

GQYT
 |  
sqer
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 904-969 4.7e-08 26.7 In-house 214-289 (349) alignment 
Range on Protein: 904-969
Range on HMM: 214-289/349.0
SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDeVR-----------KARQGSVDPIVVHCSAGIGRTGVLILMETAA
...   . |.|.  |.| ..  .|. ..| .. |.              .  . ...|||||| ||||||. ..   
vekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 905-1009 1.9e-10 35.0 In-house 212-341 (350) alignment 
Range on Protein: 905-1009
Range on HMM: 212-341/350.0
SEERRVTQMQYIAWPDHGVPDDPKHFIQFVD------EVRK----ARQGSVDPIVVHCSAGIGRTGVLILMETAAC-----------LVESNEPVYPLD-
|.   | |.|.  |.| ..  .|. ..| ..      .         .   .||.||||||.||||.|. ..                .... .    | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

---IVRTMRDQRAMLIQTPGQYTFVCESIL
   ||  .| ||  ..|.  |. |. |..|
isiivnelrkqrismvqnldqfifiYeall
0038934 (Phosphotyrosine protein) phosphatases II 909-1004 2.4e-11 39.1 In-house 78-169 (194) alignment 
Range on Protein: 909-1004
Range on HMM: 78-169/194.0
RVTQMQYIAWPDHGVPD---DPKHFIQFVDEVRKARQGSvdPIVVHCSAGIGRTGVLIlmetAACLVESNEPvYPLDIVRTMRDQRAMLIQTPGQYTFV
.  .   . .||.|..      ..|...|||. .. .|    ..||| ||.||||.|.    || |....    . . ....|. |   |......  .
agieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAialfrekRpgaipnqdyleal
PTPc_DSPc_SM00012 910-1009 1.5e-30 100.9 In-house 2-104 (105) alignment 
Range on Protein: 910-1009
Range on HMM: 2-104/105.0
VTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV--DPIVVHCSAGIGRTGVLILMETAACLVESN-EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCE
|....| .|||||||............|.| .. |    |.|||||||.||||........ . .|.. . |  ..||. .|.||. ..||  || |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SIL
 .|
all
subfamily_PTPDC1_pd Subfamily PTPDC1 913-1006 2.9e-09 31.6 In-house 85-170 (182) alignment 
Range on Protein: 913-1006
Range on HMM: 85-170/182.0
MQYIAWPDHGVPDdPKHFIQFVDEVRKARQGSvdPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQRAMLIQTPGQYTFVCE
.  ..|.|.||.   .. .. |  |  | |     . ||| || |||||||    |. || ... . . . ....|..|.  ||| .|  .| |
vynfgwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvli....acylvyakr.ltaekaiklvrskrpksiqtreqvelvke
subfamily_CG42327_pd Subfamily CG42327 938-1006 1.5e-10 35.3 In-house 240-309 (319) alignment 
Range on Protein: 938-1006
Range on HMM: 240-309/319.0
RKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESN-EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCE
| ... |  |.||||| |.||||..|  . |   .| . . |   ..|  .| .||  ..|  || |.  
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 939-1010 3.6e-13 44.0 In-house 222-293 (297) alignment 
Range on Protein: 939-1010
Range on HMM: 222-293/297.0
KARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.| .    ...||||||.||.||..| .. .  .  .       |.. .|.|||.|.||  |.... . .|.
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 948-1012 1.8e-07 25.4 In-house 1-65 (69) alignment 
Range on Protein: 948-1012
Range on HMM: 1-65/69.0
IVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
.|||||.| |||| .| .      . |.  |  .. |. ||  | |..    .| |. ...  | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 949-1015 2.6e-07 24.9 In-house 1-67 (69) alignment 
Range on Protein: 949-1015
Range on HMM: 1-67/69.0
VVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDG
|||||.| |||| .| .      . |.  |  .. |. ||  | |..    .| |. ...  |   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG