Gene ptp-1 in Caenorhabditis elegans

Synonym: CELE_C48D5.2, ptp-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP159_AA protein Get Run
CeleP159_AA_735-1013 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 33-113 3.5e-25 78.1 Pfam-A 1-80 (80) alignment
Range on Protein: 33-113
Range on HMM: 1-80/80.0
VTFLDSTSYHFEIEKNSLGIVLLEKVFNYLEIIEKDYFGLVFiavDNSSAQQKKWLDPSKNLRKQMIC--PPYHLFFRVKFYV
|..||.| ......... | ||||.|.. |...|..||||.|   .. ......|||..|.||.|.    .|. |..||||||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLaf...kedkknesnwLdhdktlreqgveegkpttlllrvkfyv

FERM_M FERM central domain 115-226 1.4e-21 67.1 Pfam-A 1-126 (126) alignment
Range on Protein: 115-226
Range on HMM: 1-126/126.0
DPNRLRDEFTRFQFYQQVRQNLEEGRLPCNEGSLALLASYVVQAEVGDFE-EKTHGMSR--TCLCY-----------KIQFATLPDDFSDRVAELHQLHI
|||...|| .. ..|.|....| |.||.|.| ...|||.. .|.|.||.| |...  |   . ...           ...     ...  |..| |. . 
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GQTPDVAEQNFLDHARRLEMYGMDVY
|.... |....|  |..|..||....
glslaeaklkylqaaqslpdyGvslF

FERM_C FERM C-terminal PH-like domain 232-318 1.5e-24 76.4 Pfam-A 3-89 (90) alignment
Range on Protein: 232-318
Range on HMM: 3-89/90.0
NHLPIEIGVGAVGIKVFHEGIKM--NEYAWVRIRKLSFKKKQFQVLVANedGVSETIMIFNIMSAKICKLLWKCCIEQHTFFRLKTPPK
.   . .|| | |......  |.  ... | .|||||||.|.| . . .    ... . |.. .....|||.|.|||.|..|| . ...
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd..ekkkdvlkFyssqlrvnklllklcienhdlfrrrrkvd

FA FERM adjacent (FA) 323-368 2.6e-17 51.4 Pfam-A 2-46 (47) alignment
Range on Protein: 323-368
Range on HMM: 2-46/47.0
KVFNFGSKFRYSGRTEYQTLEENEHrKSAGHRNFHRSLSKSSFLRS
|.| .|||||||||||.|..||. . ..  ...|.||.||..  |.
kffslGSkFRYSGRTekQvieesre.igrkppsfeRspskrylsrr

PDZ PDZ domain (Also known as DHR or GLGF) 618-703 2.3e-25 78.7 Pfam-A 2-81 (81) alignment
Range on Protein: 618-703
Range on HMM: 2-81/81.0
IKMRPDRHGRFGFNVKGGADQN-YPVIVSRVAPGsSADKCQPrLNEGDQVLFIDGRDVSTMSHDHVVQFIRSARSglnggELHLTIR
... ....|..||..||| |..  ...||.| || .|..... |.|||..| ..|.||...|||..||.|.....     |..|||.
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg.....evtLtil

0039614 (Phosphotyrosine protein) phosphatases II 728-1010 1e-82 273.3 In-house 9-287 (297) alignment
Range on Protein: 728-1010
Range on HMM: 9-287/297.0
ADSVPNSDKLSKSLQLLADSLNSGKVVDHFEMLYRKKPGmsMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS----GDYINANYVnmeiPSSGI-VNR
 .|.| . .    |.|| . ......  .||.|.. ||   . |..| .|  ||||.|. |||..|| |.  ..     |||||.||    .   .  ..
lesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrk

YIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRvKCHQYWPRVFEtqEYGRLMIKCIKDKQTTNCCYREFSIRDrnSSEERRVTQMQYIAWPDHG
.||.|||| .|  ||| |||||..|.|||||. .|.|| ||.||||   .  .||.. ....| ..  ....|......  ..|.| ||..||. |||||
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhg

VPDDPKHFIQFVDEVRKARQG--SVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
||........|...||.|..   .  |..||||||.||||..|.. .. ...|..  | .|..|...| || . .|||.|| |... .| 
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

0051299 (Phosphotyrosine protein) phosphatases II 736-1010 1.6e-89 295.5 In-house 9-284 (288) alignment
Range on Protein: 736-1010
Range on HMM: 9-284/288.0
KLSKSLQLLAdSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAH
.| | .. |    .  .. . ||.|....| .......| .|| ||||.|. |||..|| |.  ..   .|||||.|.    .   . ...||.|||| .
ellklvlkll.angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpn

TSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDR----NSSEERRVTQMQYIAWPDHGVPDDPK
| .||| |||||....|||||...|.||.||.||||   ....||........ ..  ....|.. ...      ..|.|.||...|..||||||||.|.
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

HFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
....|. .||||.. .  |.|||||||.||||..|..... ...| .. | .|..|...| || ...||| || ||.| .| 
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

subfamily_PTPN3_pd Subfamily PTPN3 737-1016 7.5e-149 489.2 In-house 1-279 (280) alignment
Range on Protein: 737-1016
Range on HMM: 1-279/280.0
LSKSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNMEIPSSGIVNRYIACQGPLAHTSSD
|..||.||...|.||.|. .||.|||||||......|...||.||||||..|||.|||.|..|.. ||||||||||||||.|.||||||.|||||.|..|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatd

FWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDE
|| |||||....||||||..||||||||||||.  ...|||....|| |...|.....||. ..|....|||...|.||.||||||||||...|..||..
fWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefver

VRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGT
|||.|.|. .|.||||||||||||||||.||| .|.|..|||||||||||||||||||.||..||.||||.||..|....
vrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeil

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 737-1013 6.5e-70 230.7 In-house 10-284 (319) alignment
Range on Protein: 737-1013
Range on HMM: 10-284/319.0
LSKSLQLLADslNSG-KVVDHFEMLYRKKPGmSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipSSGIVNRYIACQGPLAH
| . |. ||.  ..  ..   |..|   ..  ... .    |  ||||... .|| |||.|..   ... |||||....    .    ...|| |.||..
Lkerlkalas..tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlen

TSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFI
| .||| ||||... ..|||| ..|...||...|||.  . .|||||...  ..... .   |..... ..|  | |.|.. || .||||.||.. .  .
tiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

QFVDEVRKARQG-SVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
... ..||.|.. .  |||||||||.||||  | .. .   |. .. .    .|...| || ...|.| ||.|. | .| | .
dllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

0050432 (Phosphotyrosine protein) phosphatases II 739-1013 2.2e-94 311.5 In-house 30-300 (308) alignment
Range on Protein: 739-1013
Range on HMM: 30-300/308.0
KSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLqaSPSGDYINANYVNMEIpsSGIVNRYIACQGPLAHTSSDFW
. |.|| . |..|..   || |...|| .......| .|  ||||.|. ||| .|| |  ... |||||.||.. .  |.. ...||.|||| .|  |||
dllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgys..sklprkfIatqgPlpntvedFw

VMVWEQHCTTIVMLTTITERGRVKCHQYWPRV--FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDE
 |||||....|||||...|.||.||.||||     ...|||.. ..... ..  ....|.. ... ...|.|.||...|..|||||||..|.....|...
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VRKARQGsvDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
||| ..|   |||||||||.||||..|..... ...| .  | ....|...| ||.. .||| || |... .|  ..
vrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

subfamily_PTPN14_pd Subfamily PTPN14 739-1010 2.1e-73 241.9 In-house 11-294 (300) alignment
Range on Protein: 739-1010
Range on HMM: 11-294/300.0
KSLQLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS--PSGDYINANYVNMEIpsSGIVNRYIACQGPLAHTSSD
|  . |   |..|||   .| . .|.    .. ..|  |  |||..|| ||.|.|| |...   | .||||  ... .  .|    ||..|||| .|  |
krakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv..ggkersyivaqgPleltvqd

FWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV---FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQF
|| |||||. . ||||| ..| |. |...|.|.     .| |.|.  .     .... .  . . ..   |.||| |  .||. |||||||.|.|.|...
fWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy

VDEVRKAR---QGSVD------PIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
..||.  |   . .|.      |..||||||.|||||||| .     .| || .    .....| || .|.|| .||.|| . ...
LeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

0036941 (Phosphotyrosine protein) phosphatases II 742-1016 1.6e-89 295.4 In-house 4-281 (297) alignment
Range on Protein: 742-1016
Range on HMM: 4-281/297.0
QLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLqASPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMV
.|| ..|.. ..  .|| |.. .. .|... .| .|| ||||.|. |||.||| |  ... |||||.||    .  .. ...||.|||| .|  ||| ||
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmv

WEQHCTTIVMLTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQ--TTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVR
|||..|.|||||. .|.||.||.||||    |...||........ ..   .....|.. . | ...|.|.||...|. |||||||..|.....|...||
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KARQG--SVDPIVVHCSAGIGRTGVLILMETAACLVE---SNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGT
|...   |  |..||||||.||.|..|..... ...|    .. | .|..|...|.||.. .||..|| |..| .|  .  ..
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0047943 (Phosphotyrosine protein) phosphatases II 742-1009 1.7e-86 285.3 In-house 3-269 (273) alignment
Range on Protein: 742-1009
Range on HMM: 3-269/273.0
QLLADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLqASPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMV
.|| ..|.....   ||.|.. || .......| .|. ||||.|. |||..|| |  ... |||||.||    .   . ...||.|||| .|  ||| ||
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmv

WEQHCTTIVMLTTITERGRVKCHQYWPRVFE--TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRK
|||....|||||...|.||.||.||||   .  ...||.. ..... ..  ... |.. ... ...|.| ||...|  |||||||........|...|||
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

ARQG--SVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|..   |  |.|||||||.||||..|..... ...| .  | .|..|. .|.|| . .||| || |..| .|
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

subfamily_PTPN13_pd Subfamily PTPN13 744-1011 5.4e-80 263.6 In-house 4-268 (273) alignment
Range on Protein: 744-1011
Range on HMM: 4-268/273.0
LADSLNSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgdYINANYVNMEIpsSGIVNRYIACQGPLAHTSSDFWVMVWE
| . |....  . |. |   ||  . .. .  .| .|||||.| |||.|||.|... .  ||||.......       .|||||||| .| .||| ||||
lqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvwe

QHCTTIVMLTTITERGRVKCHQYWPRVFE--TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKAR
|... |.|.|.  |.|.||||.|||   .  .. ..|| .. .| ..  .   |.. ..| .|.| |.|.......|||||||  .....||| |||. .
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq

QgSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
. .  ||||||||||||.|.|| ....  |.| ....   .|||..|.||  ..||  || || ..|| .
t.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 745-1008 3.2e-24 79.9 In-house 20-281 (302) alignment
Range on Protein: 745-1008
Range on HMM: 20-281/302.0
ADSLNSGKVVDHFEMLYRKKPGMSMniCRL-TANLAKNRYRDVCPYDDTRVTLQASPsGDYINANYVnmEIPSSGivNRYIACQGPLAHTS---SDFWVM
 .||....| . |. .   |  . .  |..  .||.||.  ||  .|...| |.|.|  .|.||  |  |.|. .  .  |  | |   ..    .|| |
vksldtaevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleaep.dsyvnaskv..evPelt..rsiilaQlpkvdsedsveeFWrm

VWEQHCTTIVMLTTITERGRvKCHQYWPRVFET-QEYGRLMIKCIKDKQTTNCCyREFSI--RDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEV
|........|.|    |  .   ....|.  .. .|||....   | ... .    ...|     . |.   ..      |... ||.   . |. . .|
vfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

RKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
 .  . . ...|.    |.|| |... . .| . ..... .   .||...| ||.  ...  ||...  ..
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial

0040438 (Phosphotyrosine protein) phosphatases II 746-1013 1.9e-88 292.1 In-house 13-277 (317) alignment
Range on Protein: 746-1013
Range on HMM: 13-277/317.0
DSLNSGKVVDHFEMLYRKKPGmSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVW
. .. ... ..||.|.. |.  .... .| .|  ||||.|. |||..|| |.  ..    |||||.||    .   . ...||.|||| .|  ||| |||
lksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvw

EQHCTTIVMLTTITERGRVKCHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ
||..|.|||||. .|.||.||.||||   ||..||........ ..  ....|.. . | ..||.|.||...|..|||||||..|.....|...||.|..
eqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

GSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
..  |..||||||.||||..|..... ...| .. | . ..|...| ||.. .|||.|| |... .|  . 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk

subfamily_PTPN6_pd Subfamily PTPN6 746-1009 1e-75 249.6 In-house 21-294 (306) alignment
Range on Protein: 746-1009
Range on HMM: 21-294/306.0
DSLNSGKVVDHFEMLYRK--KPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL--QASPSGDYINANYVNMEIPSSGivNRYIACQGPLAHTSSDFWVMV
.||.   . ..|| | ..  |  .| .  . . |  ||||. . |.|.|||.|  .  |  |||||||.. |...|   ..||| || | .| |||| ||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmv

WEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIR-DRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKA
|..... |||.|. .|||. || .||| . |..|||.. ......|....  .||.|.   ....|||.| |... .||||||| ||.....|...|.. 
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrk

RQGSV----DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDI---VRTMRDQRAMLIQTPGQYTFVCESIL
.. .      |||||||||||||| .|....   |.|..   ...||   |...|.||  |.||  || || ..| 
qeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 747-1011 6.1e-75 246.9 In-house 12-275 (281) alignment
Range on Protein: 747-1011
Range on HMM: 12-275/281.0
SLNSGkVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWE
. |.|  . ..| |.    . . .  .  .|  ||||.... || |||..   ... . ||||||.|    |.    ..|||.|||. ..  .|| ||||
ndnaG.fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfv....pgykgekeyiatqgPvPaslvafWqmvwe

QHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIrDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG
|. ..|||.|   | |..|||.|||   .. .|| ...| .. .....   |.|.. .|.|.|.|.|.|..|.||||||||...|....| .||.|... 
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

SV-DPIVVHCSAGIGRTGVLILMETAACLVESN-EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
.   |.|.|||||.||||. | .....  ||.. |.. . ..|. .| .| ...||  ||.||   .|.|
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 748-1008 2.1e-41 136.6 In-house 12-289 (301) alignment
Range on Protein: 748-1008
Range on HMM: 12-289/301.0
LNSGKVVDHFEMLYRKKPgMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNME-IPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHC
 .| |. .... |.....  |...    .| | ||.... .||| |..|.  |. |  . .|.| . | .    ...|| |||. .|  ||| ..|... 
khsnkfeeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TTIVMLTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTTNCC-----------------YREFSIRDRNssEERRVTQMQYIAWPDHGVPDDPK
..|||.|   |. . ||.||||.   |..|.| . .. ....   .                    |.| .. ..  . . |.|.| . ||..||  .|.
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrepr

HFIQFVDEVRKARQ-GSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
  .| .|.| ...|  .  |.|||||....|.|| . .. .   . ..  |   ......| ..   ..|  |||.. . |
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 749-1013 2.4e-73 241.7 In-house 19-281 (288) alignment
Range on Protein: 749-1013
Range on HMM: 19-281/288.0
NSGKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQH
|   ...... |   .   | .. ||. |  |||||.. ||| .|| |.     .. |||||.|.. |    .  ..||| |||||.|  ||| .|.|..
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenk

CTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRdrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV
 .|||||| . |.|. ||..|||   . ..|| . .. ...|....   |.. .    . .|...||.|| ||||||||.. . ...... |  | |  .
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadt

DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY-H
 ||.||||||.||||. | ....   ||... .  ...|  .| |||.|.||  || |. | .|    .
gpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee

subfamily_Ptp69D_pd Subfamily Ptp69D 749-1012 2.5e-64 212.3 In-house 21-286 (307) alignment
Range on Protein: 749-1012
Range on HMM: 21-286/307.0
NSGKVvDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQH
. |..   .|.| ...   | ..     |. |||| |. ..|.||| |.      . |||||....    .    ...|| |.|.  |  ||| |..||.
dfgla.keyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPveatigDfWRmiaeqe

CTTIVMLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-----SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKA
 |.||||. .||  | ||..|||   ....|| ...|... .....   ||...   .       ..|.|.| .| .|.|  ||. ..  ......||. 
vtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

RQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
 . .  ||||||||| ||.|... ..     .. .. |   ..|. .| || .|.|   ||.|.  ..|   
yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

0043336 (Phosphotyrosine protein) phosphatases II 750-1009 1.2e-82 272.8 In-house 19-274 (278) alignment
Range on Protein: 750-1009
Range on HMM: 19-274/278.0
SGKVVDHFEMLYRKKPgMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHC
  ..  .|| |.. |. ....|..| .|  ||||.|. ||| .|| |.  ..    |||||.||    .   . ...||.|||| .|  ||| ||||...
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgv

TTIVMLTTITERGRVKCHQYWPrvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVD
|||||||. .|.|||||.||||   ....||.. ....| ..  ... | . . .. ..|.| ||...|..|||||||........|. .||.|.. |  
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsng

PIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|..||||||.||||..|..... ...|..  | ....|...| ||.. .||| || |..| .|
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

subfamily_PTPRB_pd Subfamily PTPRB 751-1013 9.3e-82 269.3 In-house 25-286 (293) alignment
Range on Protein: 751-1013
Range on HMM: 25-286/293.0
GKVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCT
 ......|.|   .  ..... .|..| |||||... ||| .|| |   . ... |||||||    ||     . .||.|||| .|  ||| ||||....
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkss

TIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDrnSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKAR--QGSV
.||||| . |.|.|||..|||.  |.. || . .. ........   ||..|.   ..|||.|.|.....|||||||...| ...|| .||.|   . | 
iivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektask

DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
 |||||||||.||||..| ...    .|... |  . ||  .| .|..|.||  || |. ...|.  .
rPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 751-1008 2.6e-62 205.7 In-house 22-279 (305) alignment
Range on Protein: 751-1008
Range on HMM: 22-279/305.0
GKVVDHFEMLYRKkpGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGD---YINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCT
 ..  ....||..  . |... . .|| ||||.... ..|| |. |....| |   ||||.||.    .    ..||. |||| .| .||| ...| . .
kgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvs

TIVMLTTITERGRVKCHQYWPRVFET-QEYGRLMIKCIKDKQTTNCCYREFSIRD-RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV
|||||| . | |. ||.||||      .|.|.....    |....   |...|   ....|.| |.|.|   |||||||. .  .......|.|... . 
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

D-PIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
. |..||||||.||||| | .. |   ..  | |   ......| .|  ..||  ||.|. . .
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 751-1010 6.6e-42 138.6 In-house 16-275 (307) alignment
Range on Protein: 751-1010
Range on HMM: 16-275/307.0
GKVVDHFEMLYRKKPGmSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS-PSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHCTTI
 ..|| |..| .|.|  ....  ..||  ||||.||   | .|. .. .  . ||| |||. . |      ...|..||||  |  .|| |. ...  ..
qalvdefrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiqekvesv

VMLTTITERGRVKCHQYWPRVFE-TQEYGR----LMIKC--IKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRkarq
.||  . | ...||.|||| .   .. .|     . ..   .|     . .    ...   ... | ....|.  |||.|||.     | ... ||    
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....

GSVDPIVVHCSAGIGRTGVLILMET-AACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.  .|.|||||||.||.| .. .      ...  .     ..|. .|.||   |||  || ..   .| 
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle

0045450 (Phosphotyrosine protein) phosphatases II 752-1011 5.6e-84 277.7 In-house 28-303 (307) alignment
Range on Protein: 752-1011
Range on HMM: 28-303/307.0
KVVDHFEMLYRKKP--GMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS----GDYINANYVNMEI----PSSGIVNRYIACQGPLAHTSSDFWVMV
..  .||.|.. ..   ....| .| .|  ||||.|. |||.||| |.  ..    .|||||.||.. .    ..  . ...||.|||| .|  ||| |.
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDR-NSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKA
|||..|.|||||. .|.||.||.||||   |...||.. ..... ..  ....| . . |   ..|.|.||...|..|||||||........|..|||||
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

RQG--SVDPIVVHCSAGIGRTGVLILMETAACLVESNEP---VYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
..   .  |..||||||.||||..|.. .. ...|...    | .|..|...|.||   .|.|.|| |..| .|  
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 752-1012 1.7e-56 186.3 In-house 21-283 (290) alignment
Range on Protein: 752-1012
Range on HMM: 21-283/290.0
KVVDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS-GD----YINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHC
.  ..|.||   .   ....   . |  .||.... .||| |.||.  ..  |    |||| |..    .    ..||| |||. .|  ||| ..|....
gfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek....kqyiatqgpvsntlvdFWkliwqekv

TTIVMLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNS-SEERRVTQMQYIAWPDHG-VPDDPKHFIQFVDEVRKARQGS
| |||||.|.| |.|||.||||   .|..||   || ........   |.......||  ... ||| |  .|...| |..     ...   ... |.  
tiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

VDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
  .||||||...||..|.. ..|.   ....  .  .......| |.  ..||  || .... .|.. 
ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

0045098 (Phosphotyrosine protein) phosphatases II 754-1012 4.8e-77 254.3 In-house 10-272 (278) alignment
Range on Protein: 754-1012
Range on HMM: 10-272/278.0
VDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTlqaspsgDYINANYVNMEiPssgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLT
   || |..  .  ...   .  ||.||||.|. ||| .||        |||||.|...  |     ...||.|||| .| .||| |.||...|.|||||
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivmlt

TITERGRVKCHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDR----NSSEERRVTQMQYIAWPDHGVPDDP--KHFIQFVDEVRKARQ-----
. .|.||.||.||||   ....||.. ..... ... . ..| . ...     .. |.| ||...|. |||||||..|  |.|.......|.|..     
elvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasl

---------GSvDPIVVHCSAGIGRTGVLILMETAACLVesNEPVYPLDIVRTMRDQRAM-LIQTPGQYTFVCESILRAY
         ..  |..||||||.||||.|... .  .|.  .. | .|..|...| || .  .|...|| |..| .|. .
llsslllldsg.gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 754-1014 1.9e-76 252.2 In-house 23-282 (318) alignment
Range on Protein: 754-1014
Range on HMM: 23-282/318.0
VDHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIV
   .|.| |..  ..       .| ||||| .. .||.||| ||    ... |||||||..         . |||.|.||..| .||| |||||....||
seeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy....rrkkayiaaqaPlpetieDfWrmvWeqnsaviv

MLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKAR-QGSVDPIV
||| ..|||..|.|.|||   ....||.|...  .......   |||... ....|.| | | .| .|||.|||... .....| .|.||  . ...|||
mltqeeergkakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpiv

VHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHD
||||||.||||| | ...    .. .. |  ...|...|.|| ...||  ||.|. . .| | . 
vhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

0046845 (Phosphotyrosine protein) phosphatases II 755-1012 7.4e-88 289.9 In-house 4-274 (284) alignment
Range on Protein: 755-1012
Range on HMM: 4-274/284.0
DHFEMLYRKKPGM--SMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS----GDYINANYVNME-IPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCT
. ||.|.. .. .  |.....| .|| ||||.|. |||..|| |.  ..    .|||||.||..  .. . | ...||.|||| .|  ||| |||||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

TIVMLTTITERGRVKCHQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GS
.|||||...|.||.||.||||   |...||........ ..  ....|...... . ..|.|.||...|..|||||||..|.....|...||....  ..
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

VDPIVVHCSAGIGRTGVLILMETAACLVESNE---PVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
  |||||||||.||||..|..... ...| ..    | .|..|. .|.|| . .||. || ||.| .| ..
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

DSPc_SM00195 755-1011 1.2e-82 272.6 In-house 4-261 (263) alignment
Range on Protein: 755-1011
Range on HMM: 4-261/263.0
DHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVM
 .|| | ....  ...  .  .| .||||... |||.||| |. ..   . |||||||....       ..|||.|||| .| .||| ||||.....|||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTT-NCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIV
||   |.|. ||..|||.   .....|.. .|... ...  ..  |.....  . .|.|.|||.|| .||||||||..|...... .|.| .. |  |||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||||.||||........   .|... |   .||. .|.||....||  ||.|..| ||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 755-1011 1.2e-82 272.6 In-house 4-261 (263) alignment
Range on Protein: 755-1011
Range on HMM: 4-261/263.0
DHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVM
 .|| | ....  ...  .  .| .||||... |||.||| |. ..   . |||||||....       ..|||.|||| .| .||| ||||.....|||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTT-NCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIV
||   |.|. ||..|||.   .....|.. .|... ...  ..  |.....  . .|.|.|||.|| .||||||||..|...... .|.| .. |  |||
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||||.||||........   .|... |   .||. .|.||....||  ||.|..| ||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_PTPN9_pd Subfamily PTPN9 755-1009 8.3e-67 220.3 In-house 20-287 (297) alignment
Range on Protein: 755-1009
Range on HMM: 20-287/297.0
DHFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVM
 ... . ....   ..  .| ||| |||| ||  ||.|||.|.     .  ||||||.|.         . .|| |||| .|.|||| |||||.. .|||
keyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy....kqkkafiatqGplkktvsdfWrmvWeqevlvivm

LTTITERGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV-----
 | . ||||.|| ||||    ...|.| | .. ...... .   | . |.. . .|.|.||  |...|||.|||.. . .......||...  .|     
ttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

--------DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
         |||||||||||||| .| .. .   .|. . |   . |...| |||  |||| ||.|   ..|
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 755-1013 5.5e-47 155.2 In-house 24-280 (439) alignment
Range on Protein: 755-1013
Range on HMM: 24-280/439.0
DHFEMLYRKKPGMSMNIC--RLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHCTTI
. ||..   .|  . . .      . .||||.|| ..| ||||||     |   ||||||..         . |||.|||  .|. ||| .|.|....||
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd....klyiatqgpkkettddfwrlviekktvti

VMLTTITERGRvkchqYWPRVFETqEYGRLMIKCIKDKQTTNCCYREFSI---RDRnSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ-GSV
|||| . |  .     |||   |.  || ..... .. .  | . | | .   ||. .  || | |..||||||. || .  | ..|.  .  | .   .
vmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdt.tekertvlqfhyiawpdknvpaqashvldflrainsandkeey

DPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
 |.|||||||.|||| .| .. |   . ... |    ||. .|.||  ..|.  || |. ...|    
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv

subfamily_PTPRD_pd Subfamily PTPRD 756-1013 1.2e-85 283.3 In-house 28-282 (564) alignment
Range on Protein: 756-1013
Range on HMM: 28-282/564.0
HFEMLYRKkPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVML
 .. . .. . .... ..  || ||||| ....|| .|| |.   . .. |||||....    .    . ||| |||||.| .||| |||||...|||||
eykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

TTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHC
| . |.|.||||.|||   .|..||.|...  . .. .. . |.|.... .||| | |.| ....|||||||. ..........||....    ||||||
tkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhC

SAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
|||.||||. | ..     ..... |    .|...| || ...||. || |. | || | .
SaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

subfamily_PTPRN_pd Subfamily PTPRN 756-1008 5.9e-50 164.7 In-house 34-288 (297) alignment
Range on Protein: 756-1008
Range on HMM: 34-288/297.0
HFEML--YRKKPgMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEIPSSgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIV
..| |  |. .|  . ....   |. |||...| |||..||.|...    . |||||  .  . | .     |||.|||||.| .||| ||||| .. ||
ewealcayeaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra...payiatqgplastvadfwqmvweqGvvviv

MLTTITERGRVKCHQYWPRVfETQEYGRLMIKCIKDKQT-TNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIV
.||...| |  .|..|||    .. |.   .. . ..    .   | | ... ..|| | |||. ...||..|||  .| ...|   | |. .|   |||
nltrleeegvkqckrywpde.GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpiv

VHCSAGIGRTGVLILMETAacLVESNEPVYPLDIVRT---MRDQRAMLIQTPGQYTFVCESI
||||.| ||||| ||..    |   .  |  .||. |   .||||. |..|  |. |.  ..
vhcsdGaGrtGvyilidlv..lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_CG7180_pd Subfamily CG7180 756-1012 1.6e-44 146.7 In-house 18-290 (296) alignment
Range on Protein: 756-1012
Range on HMM: 18-290/296.0
HFEMLYRKKPGMSMNICRLT---ANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTI
 ....... | .... |.      |. |||. .| ||| .|| |.      . ||||| ||.    |    . ||  ..|  .|  .|| .|..... ..
eyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisav

VMLTTITERGRvKCHQYWPRVFeTQEYGRLMIKCIKDKQTTNCCYREFSIRDR----------NSSEERRVTQMQYIAWPD-HGVPDDPKHFIQFVDEVR
|.||  ..  . ....|||     ..|| .... .. || .|   |.| .  .           . |.| |...|.  |.  . ||   . .|...  ||
vvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr

KARQGS-----VDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
. |.         |.||..| | .|.|| . .. .  ||| .| |   . |.|.| .|  |...  .| .. . .| |.
lwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 756-935 4.8e-40 132.3 In-house 12-191 (297) alignment
Range on Protein: 756-935
Range on HMM: 12-191/297.0
HFEMLYRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP-SGDYINANYVNMeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTT
. ..|.... | |.  ..  . | ||||||.  .||||| |. ..   |||||.|| .  |      .||  ||||  |  ||| .|.||   .|||.. 
ekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

ITERGRVKCHQYWPRVF-ETQEYGRLMIKCIKDKQ--TTNCCYREFSIRDRnsSEERRVTQMQYIAWPDHGVPDDPKHFIQFVD
. | || ||  |||.|  | .. | .... . .      .    |. .  |  ||.| |. .|...||||||| | .   .|  
lqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqa

subfamily_eak_pd Subfamily eak 760-932 7.4e-14 45.9 In-house 35-202 (332) alignment
Range on Protein: 760-932
Range on HMM: 35-202/332.0
LYRKKPGMSMNICRLTANLAKNrYRDVCPYDDTRVTLQASPS--GDYINANYvnMEIPSsgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITE
| .... .|..  . . .. .|   .. |||   | | .|      ||||    .| .   . ..||    .       || || ||.  .||.|    |
lddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinasl..aefse..vGrkyiltGiasedkvfafwqmvleqkspaivqlledve

RGRVKCHQYWPRVF-ETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNssEERRVTQMQYIAWPDHGVPDDpKHFIQ
 .  |  .|.|    |  ..| | ... .  .  .  .| . ..  |  |  ||   ..  | .  .|   . |. 
lkleksdkyfpdktreelkfGildverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpky.edfla

subfamily_PTPN12_pd Subfamily PTPN12 761-1010 1.9e-68 225.5 In-house 24-275 (290) alignment
Range on Protein: 761-1010
Range on HMM: 24-275/290.0
YRKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMeipsSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITE
|...  .| .  . . | .||||.|. ||| .||.|.        ||||||...     .    .||| ||||..| .||| |.||.. . .||.  . |
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg....vegkleyiaaqgPLpktlddfWrmiweknveivvmaCreve

RGRVKCHQYWPRVFETQE-YGRLMIKCIKDKQTT-NCCYREFSIRDRnsSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAG
 |. ||..|||   |..  .| . ......|... .   | . .. .  .|.|.|.|..| ||||||||  .|. ......||. .. .  |.|||||||
lgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaG

IGRTGVLILMETAACLVESNEP---VYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.||||..| .. .  |....     .   |.|...| ||| |.||  ||..| .... 
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 762-1010 8.1e-56 184.6 In-house 46-289 (319) alignment
Range on Protein: 762-1010
Range on HMM: 46-289/319.0
RKKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTtiter
.  ..  .. . |  |  |||. .. ..| ..| |.        ||||| .|.         ..|||.||||  |  ||| |.||..|.|||.||     
lgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt.....

gRVKCHQYWPRVFEtQEYGRLMIKCIKDKQTTNCCYREFSIRD-RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GSVDPIVVHCSAG
 . || ||||   . ....|  .|    ..| .   |.. . .  .  . |..||  .  |||.|||| |  ....|. ||. ..      .||||||||
.kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaG

IGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.||||| | ...    .. .. |   ..|| .|.||  |.|   || |.  ..| 
vGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 763-1011 4.3e-55 182.2 In-house 11-254 (284) alignment
Range on Protein: 763-1011
Range on HMM: 11-254/284.0
KKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTtiterg
  .|  .. . |  |  |||. .. ..| ..| |.        ||||| ...         ..|||.||||  |  ||| |.||..|.|||.||      
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......

RVKCHQYWPRVFEtQEYGRLMIKCIKDKQTTNCCYREFSIRD-RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GSVDPIVVHCSAGI
. || ||||   . ....|  .|    ... .   |.. . .  .  . |...|. .  |||.|||| | .....|. ||. ..      .||||||||.
kdkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagv

GRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||| | ...    .. .. |   ..|| .|.||  |.|   || |.  ..|  
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 763-1016 1.8e-49 163.6 In-house 34-292 (325) alignment
Range on Protein: 763-1016
Range on HMM: 34-292/325.0
KKPGMSMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMV--WEqhCTtIVMLTTITE
 . |.....  . .| ||||...| ..| .|| |   . .|| |||||.|.. ..      . ..|.| ||..|  |.| .|  |.  |. .|... . .
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk....dvflaaqaPltatindlWrlvldWr..cs.vvvvlneld

RGRVKCHQYWPRV-FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQ---FVDEVR---KARQGSVDPIVV
 |  .| .|||.   .....| | .| .  .. ..  .| . ... .  | | | |.|. .|.| ||.  |  .|     |..|    .|   .  ||.|
lgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDGT
|||||.|||||.| . .|.  |  .  |  .. |. .| .|  ...|  ||... |..  ||  | 
hcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgn

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 764-1011 1.8e-51 169.8 In-house 36-277 (287) alignment
Range on Protein: 764-1011
Range on HMM: 36-277/287.0
KPGMSMNICrlTANLAKNRYRDVCPYDDTRVTLQaSPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKC
.  . .||   . |  |||.... ..|. || |.     ||||| ...    .    ...|....|...|  .|| ...... |.||||.  .|  . .|
edevthnia..sqnkdknRltqilvpdnyrvllk.gehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevc

HQYWPRVFEtQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-SSEERRVTQMQYIAWPDHG-VPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGV
.||||       .|   |. .........  |.. .. .| ......|.| |. .|...| |..    .... . ... |. .  .||||||...||...
yqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsam

LILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
.. ..|.   .. .  .  ..... .| |.   .||  ||.|... .|  
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

0049772 (Phosphotyrosine protein) phosphatases II 764-1005 1.5e-38 128.7 In-house 33-273 (314) alignment
Range on Protein: 764-1005
Range on HMM: 33-273/314.0
KPGMSMNICRLTANLAKNRYRDVCPYDdTRVTLQASPS--GDYINANYVNMEipssgivNRYIACQGPLAHTSSDF----------WVMV--WEQHCTTI
 | ... ...| .|  |||| |..|.| .|| |.  |    |||||.||.         ...||.|||| .|  ||          | ||  ..... .|
lpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------LTTITERGrvkcHQYWPRVFETQEygrlmikcikdkqttnccyrefSIRDRNSSEERRVTQMQYIAWPDHGVPdDPK
||                     |......|     ..... .|. .                      .. . ..  ||.. .  .| .||...| ...
vmsrdevladelsrLdaAlgKtpllildgng....neptaadlellk......................eelydpelferlgikylripvpDgsap.lle

HFIQFVDEVRKArqGSVDPIVVHCSAGIGRTGV-LIlmetAACLVESNePVYPLDIVRTMRDQRA-----MLIQTPGQYTFVC
.| .|.. ...|      |..|||.||.||||. ..    ||.|.  .  | . .... .| .|       .|... || |. 
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvv....aaylmkll.gvsleealedvrlkRpinpnpgfieqleqyefil

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 765-1012 6.9e-66 217.5 In-house 44-290 (298) alignment
Range on Protein: 765-1012
Range on HMM: 44-290/298.0
PGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNMEIPSSgivnRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRV
.  .... | ..|  |||| |. ..| .|| |..      .||||| ...    ..     .||.|.|| .| .||| ||.|.. .||||||...| ...
eeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn....afiatqaPltetvedFWrmvteedigtiVmltnleeldkt

KCHQYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV-DPIVVHCSAGIGRTG
|.|.||| . ....||.. ..  .... ..   |.. . ......||.| |.... |||.|||   .  ......||. .| .   |..|.||||.||.|
kyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsG

VLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
  | ...    |. .. |  ...|...| .|. ..||  ||.|. | .|.| 
tfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 765-1010 4.1e-50 165.1 In-house 42-281 (290) alignment
Range on Protein: 765-1010
Range on HMM: 42-281/290.0
PGMSMN--ICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNmeipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVK
|.  ..  |    ... ||||.||   | ||| |.    |||. ||||.      |.   .|  ||.|. |  |.| || ... ..||||  . | |. |
pvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkak

CHQYWPRV-FETQEYGRLMIKCIKD-KQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARqGsvdPIVVHCSAGIGRTG
|.||.|    |.  .| . . | .. .. .|   . .|.||..|  | ..  .. ..|||. |.     ... .  .|||  |   |.||||||||||||
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas.G...pvvvhcsaGiGrtG

VLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
 .. .|... ..     . .||.||..|. |.  .|   ||  . | .| 
tfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 765-1010 2.1e-49 162.9 In-house 21-264 (283) alignment
Range on Protein: 765-1010
Range on HMM: 21-264/283.0
PGMSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNMEIpSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCH
| .. .|     |  |||.... |.|  || |.. .  ||||| .. ..  |    ..||..|.|| .|  ||| ||.... |.||||| . |  |.|| 
pdldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsk.sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSE-ERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLI
||||.   ...|| . .   |.        .|. .|  .|.. .  ..  |.| | . |       ...|   . . ..    |||||||.|||||.|.|
qyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

LMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
 . ..   . ..  |    .|. || || |..|| .|| .| | .| 
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_PTPN23_pd Subfamily PTPN23 767-1013 7e-66 217.0 In-house 35-281 (288) alignment
Range on Protein: 767-1013
Range on HMM: 35-281/288.0
MSMNICRLtaNLAKNRYRDVCPYDDTRVTLQaSPSGDYINANYVNMEIPSSgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
.|. | .|  .  |||.||. ||| .||.|. .   ||||| .|.   | .     .|| |.||. |..||| ||.||.  .||||.. .|.|. |...|
rsiaiakl..yseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgc...PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrY

WPRV-FETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRK----ARQGSVDPIVVHCSAGIGRTGV
||    ||...| | . . . ..| ..  |..... ..... . |. .|. .||..|||. |....||.|||..     .. |  |.|||||||.|||||
wPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

LILMETAACLVESNEPVYP-LDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
. |. .|.  .| .. .   ...|...| ||   .|.  |. |. | .|.| .
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_PTPN1_pd Subfamily PTPN1 767-1010 4.5e-65 214.2 In-house 22-269 (290) alignment
Range on Protein: 767-1010
Range on HMM: 22-269/290.0
MSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNMEIpssgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
.... ..| .| ..|||||| ||| .|..|. .   |||||. |..|     .  .||  ||||..| . || |||||.. ..|||  . |....||.||
fptreaklpenrnlnryrdvspydhsrikleradn.dyinaslvelee....akrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPRVFETQ----EYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ--GSVDPIVVHCSAGIGRTG
||.  |..    |  .| .| |. ... .   | . . .... | | .... |..||| |||. |  |..|. .||..      | | |.||||||||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VLILMETAACLVESNEPVYPLDIVR---TMRDQRAMLIQTPGQYTFVCESILR
 ..|..|   |.| .. .  .|| .    .| .|  ||||. |  |   .|| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRG_pd Subfamily PTPRG 767-1011 5.7e-63 208.0 In-house 37-286 (563) alignment
Range on Protein: 767-1011
Range on HMM: 37-286/563.0
MSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPS--G--DYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVK
. ..  . . |  |||| .. .|| .||.|.  |   .  |||||||..         . .|| ||||..|  ||| |.|||. ..|||.| ..|||| |
ldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrk

CHQYWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRD---RNS---SEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGI
|..|||.  |...|| | .. |. ....    |...|..   ..     .|..|.| .|  |||||||. .   ..||    .|..  . |||||||||.
cdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGv

GRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
||||..| ..|    ..... |  .......| || .|.||  ||.|. . .| |
grtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 767-828 1.5e-08 28.7 In-house 38-95 (95) alignment
Range on Protein: 767-828
Range on HMM: 38-95/95.0
MSMNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEipssGIVNRYIACQG
 .  .    ||. |||. .. ||| |||.| .    ||||| .|.         | |||.||
apytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy....arkncyiaaqg

subfamily_PTPRA_pd Subfamily PTPRA 768-1015 1.9e-64 212.7 In-house 49-298 (330) alignment
Range on Protein: 768-1015
Range on HMM: 49-298/330.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCH
.....    |  |||. .. ||| .|| |.     .. ||||| ...         ...||.|||...|  ||| |.|||. .|||||| . || . ||.
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca

QYWPRVfETQEYGRLMIKCIKDKQTTNCCYREFSIR----DRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTG
||||    .  || . ..  ... . .   |.| ..     ..  ..| |.|. . .||| ||| .|.  .... .|.| .| | .|||||||||.||||
qywPde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

VLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDG
 .| ...    |.... |   ..|. .| ||. ..||  ||.|. . .|  |  |
tfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 768-1013 2.5e-53 176.0 In-house 40-280 (315) alignment
Range on Protein: 768-1013
Range on HMM: 40-280/315.0
SMNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCH
 ... . . |  |||| .. .|| .|| |   .  |  ||.|||.    |.     .||||.|||.. .  ||| .|.|.....||||| . |. . |. 
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanf....idGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkae

QYWPRVfeTQEYGRLMIKCIKDKQTTNCCYREFSIRDRnsSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLIL
.|||       ||.. .  ..... |. . | .|.  .  .. | | |..| .||| |||     .....  |.. .. || .||||||||.|||| .| 
kywpdk..kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfit

METAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
...    .| .. .   .... .|..|  ..|.  || |. . .| .. 
ldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 768-1005 9.5e-37 121.2 In-house 43-283 (310) alignment
Range on Protein: 768-1005
Range on HMM: 43-283/310.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQ--ASPSGDYINANYVNMEIpssgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
|.     . .. |||| ||   |..|| |.   |  .||| ||||. .     . . .| .|||| ||  ||| |.... . .|..|  ..| || ||  
sltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny....lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvg

YWPRVFETQEYGRLMIKCIKDK-QTTNCCYREFSI-RDR-------NSSEERRVTQMQYIAWPDHGVPDDPKHFIQfvdeVRKARQGSVDPIVVHCSAGI
||| .  |. || . .  . .  .  . |    ..  |           .| ||. ...  ||| ||||.  | .      |   |    | |||||||.
ywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcvvhcsagk

GRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVC
.|..|.. .. .   ..  . |   ...  .. .||. |||. ||... 
drlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid

subfamily_egg_pd Subfamily egg 768-1014 1.8e-29 97.4 In-house 31-272 (307) alignment
Range on Protein: 768-1014
Range on HMM: 31-272/307.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQAS---PSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrVKCH
|.. .    || | | . |   | .||.|.      ..|.| ||.|.       ..| .| .| ||  |  ||| ||.....  |||||.  |    .|.
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPRVF-ETQEY--GRLMIKCIKDKQTTNCCYREFSIRDRNS-SEERRVTQMQYiAWPDHGvpdDpkhFIQFVDEVRKARQGSvDPIVVHCSAGIGRTG
 |||.   ..  .  | | |...| .....  .|   ..   .  ||| .   |.  .   .   |       .  .||.|. |  |.||..  |. ...
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss...d...vysplrvlrklrnls.kpvvvqdilGvskaa

VLILMETAACLVESNePVYPLDIVRT---MRDQRAMLIQTPGQYTFVCESILRAYHD
.|. .|.| . .    |..   . |.   .| .| . .... .| ||   .|  ..|
tlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 768-1007 3.2e-22 73.5 In-house 38-274 (303) alignment
Range on Protein: 768-1007
Range on HMM: 38-274/303.0
SMNICRLTANLAKNRYRDVCPYDDTRVTLQASpsgDYINANYVNMEIPssgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYW
|.   ..  |. |||. ||   | ..| |  |    || |.|....       .. |  | ||.||..||| |. ||.   ...| | .|  ..  .  .
svsknqfvknmdknrfvdvicldhskvklsds...syihasyleldss.....kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

PRVFETQEYGRLMIKCIKDKQTTNCCYREF-SIRDRNSSEERRVTQMQYIAWPDHGVPDD--PKHFI---QFVDEVRKARqgSVDPIVVHCSAGIGRTGV
||  .  ..   .|.  . |.        .  .   | .    .   .| |||   .| |  ||      |    .||       | |    .| ||.| 
prnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys..dstptvymslsgcgragt

LILMETAACLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFVCES
. |.|||   . |...   |   . ..|. |   .|   |...|   
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytl

0040439 (Phosphotyrosine protein) phosphatases II 769-1010 3.3e-75 248.2 In-house 3-244 (249) alignment
Range on Protein: 769-1010
Range on HMM: 3-244/249.0
MNICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
.....| .|. ||||.|. ||| .|| |.  |.   .|||||.|.    . . | .|.||.|||| .| .||| |.||...|.|||||. .|.||.||.|
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaq

YWPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG--SVDPIVVHCSAGIGRTGVLI
|||   ...|||........ ..  ... |.. . .   .|.|.|...||. |||||||........|...||||..   .  |..||||||.||||..|
ywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

LMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.. .. ...| .  | ....|...|.|| . .|.|.|| |..| .|.
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 769-1008 1.7e-72 239.2 In-house 2-238 (243) alignment
Range on Protein: 769-1008
Range on HMM: 2-238/243.0
MNICRLTANLAKNRYRDVCPYDDTRVTLqasPSGDYINANYVNMEiPssgivnRYIACQGPLAHTSSD----FWVMVWEQHCTTIVMLTTITERGRVKCH
..|..| .|| ||||.|. |||..|| |   ...||||||....  |      |.||.|||| .|  |    || |.||...|.|||||. .|.||.||.
fsiallpenlsknrysdilpydhsrvkl...egsdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPrvfETQEYGRLMIKCIKDKQTTNCCYREFSIRDRN-SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG---------SvDPIVVHCSA
||||   ....||........ ... ....|.....  . . ..| |.. .|..||||||||.|.....|.||||.  .          .  |..|||||
qywp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsa

GIGRTGVLILMETAACLVesnePVYPLDIVRTMRDQRAM-LIQTPGQYTFVCESI
|.||||.||.. .   |.     | ....|...|.|| .  .|||.|| |. | .
GvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 769-1013 3.1e-61 201.9 In-house 36-278 (315) alignment
Range on Protein: 769-1013
Range on HMM: 36-278/315.0
MNICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
 ...| | |  ||||... |.| .|| |   . ||  ||||| |    |.|    . ||| ||||  . .||| ||.... |||||.|   |  ..|| |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPR-VFETQEYGRLMIKCIKDKQTTNCCYREFsiRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLIL
|||    .. |.| . .. .. ...|.   |..    |.| | |.||| |.  |||.||. .   ..... ||.  ..    ...||||||.|||||.| 
ywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

METAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
..     .. .. |  ...|...|..|  |.||  .|.|. ...|   .
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 769-1013 4.7e-40 132.2 In-house 40-288 (305) alignment
Range on Protein: 769-1013
Range on HMM: 40-288/305.0
MNICRLTANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMeiPSSgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP
|.  . . .  ||||.||   |. || |...   .|| ||||    |.    .|.| .| || .| .||| | ....  .| ||  . |.|  ||..|..
mkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvst..ptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfa

R----VFETQEYGR-LMIKCI-----KDKQTTNCCYR--EFSIrDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqgSVDPIVVHCSAGI
     |.| .| |. ...|.      | .. ..   .  .. | .   .. |.||.  .| ||| |||      .... . |     |  ||||||||||
skdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlvi.egpgekarkvthyhwidwpdrgvpaadlailellekarp....skgpivvhcsagi

GRTGVLILMETAA-CLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
|||| ....|     |.. .       |.. .|.||   |||  || || . ||  ..
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

0042113 (Phosphotyrosine protein) phosphatases II 770-1009 3.7e-76 251.1 In-house 2-240 (245) alignment
Range on Protein: 770-1009
Range on HMM: 2-240/245.0
NICRLTANLAKNRYRDVCPYDDTRVTLQASPS---GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
....| .|  ||||.|. |||.||| |.  ..    |||||.||    . . | ...||.||||..|  ||| |.||...|||||||. .|.|||||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPRvFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ-GSVDPIVVHCSAGIGRTGVLILM
||   |...||........ ..  ... |.... .  ..|.| |....|. ||||||||.......|...||||.. .|  |..||||||.||||..|..
wpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
 ......|..  | . ..|. .|.|| . .|||.|| |. | .|
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 770-1009 1.2e-60 199.8 In-house 13-261 (270) alignment
Range on Protein: 770-1009
Range on HMM: 13-261/270.0
NICRLTANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQY
..   . . . |||.|. |   |||.|.     .   |||||||.     .|  ..||| .|||. | ..|| |.||.. |.|||.| ..|.|| || .|
dlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPRVFET-QEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPK------HFIQFVDEVRKARQGS--VDPIVVHCSAGIG
||   ..  ..   .|| .. ... .  |.   .| ....||||..  .| .||||||| ..       . .. . .||. ..     .|..||||||.|
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|||.||....| .|.|... | .| |.. .| .|  |.|.| ||.|. ....
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 770-1009 6.8e-60 197.5 In-house 21-265 (274) alignment
Range on Protein: 770-1009
Range on HMM: 21-265/274.0
NICRLTANLAKNRYRDVCPYDDTRVTLQ----ASPSGDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQ
.  ... .  ||||... | . .||.|.     ..  .||||||.      ..  . |.| ||||..| .||| |....... ||||| ..|. . ||..
eeldvfgsqtknryktilPnensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCav

YWPRVFET---QEYGRLMIKCIKDKQTTNCCYREFSIRDRNSseERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG---SVDPIVVHCSAGIGRT
|.|   ..   ..|| . ||  | ... .   |.....  ..  ||.|. . | .|||| .|||.......|.||...|.     . |.|||||||||||
yfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
|. | .. |   .. .. |  | ||  .| .|  ..||  || .. . . 
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 770-1012 2.6e-58 192.2 In-house 2-242 (250) alignment
Range on Protein: 770-1012
Range on HMM: 2-242/250.0
NICRLTANLAKNRYRDVCPYDDTRVTLQASP---SGDYINANYVNMEipsSGIvNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVkCHQY
....  .|. |||| |. ..| .|| |. .      ||||| ...     ..  . .|| |||| .|  ||| ||.|.. .||||||...| ... .|||
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgy...der.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPrVFETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQG-SVDPIVVHCSAGIGRTGVLILM
|| | ....|| ....  .... ..   |.. .  .. ..|| | |.....||| |||.  .  ......|.. .|     |..|.||||.||.|  | .
wP.vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
..    .. .. |   ......| .|   ...  || || | ||.| 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 770-1010 7.3e-43 141.4 In-house 38-234 (392) alignment
Range on Protein: 770-1010
Range on HMM: 38-234/392.0
NICRLTANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGrvkchqy
....   || ||||... ||| .|| |   . .|  ||.|| |    |||    . |||.||| | . .||| ||.... |||.|.| . |         
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.......

wprvfetqeygrlmikcikdkqttnccyrefsirdrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVrKARQGSVD-PIVVHCSAGIGRTGVLILM
                                    .  . | |.| ..  |||..||     ...|. || ||  |.   |...|||||.|||||.| .
....................................kgddartvaqfhftewPdkdvpkhtssllkfikev.kadfGqythpliihcsagvgrtgvvisi

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
..  .  .    |  ...|  .| .| ...||  ||.|.  ..| 
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 771-1009 1.4e-31 104.6 In-house 37-268 (288) alignment
Range on Protein: 771-1009
Range on HMM: 37-268/288.0
ICRLTANLAKNRYRDVCPYDDTRVTLQASPSgDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV
|    || ...||...   | ||| |.  |   ||.|| |     |.   .| | .| ||  |   .| |. |.    ||||. . |.|. |  .|.| .
idsfianptrdryenlprcditrvklsddpd.fyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

F-ETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERR-VTQMQYIAWPDHGVPDDPKHFIQFVDEVrkarQGSVDPIVVHCSAGIGRTGVLILMETA
  |.  .|||     |...  .   .   .|  .  ||.  | .. .  |.|.|||.. . ...... .    .    |||||.|||.|||| |||.  |
lGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililia

ACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.  . ... .    ..  .|..|   |||  || .|   .|
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_PTPRK_pd Subfamily PTPRK 772-1014 2.4e-64 212.2 In-house 38-279 (314) alignment
Range on Protein: 772-1014
Range on HMM: 38-279/314.0
CRLTANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP
..   | .|||. |. .|| .||.|..    || |||||...     |    . .|. |||| .|  ||| .|....|..||||| ..| ||||| .|||
akkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP

RvfETQEYGRLMIKCIKDKQTTNCCYREFSIRD--RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILME
   .|. || . ..... .  ..   | |...   |. .| | | |.|...||||.||   . ....| .| | .. .  .|||||||| ||||. | ..
e..dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

TAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHD
.   ..| .. |    .|.|.|...  ...|  ||.|. . || |   
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 773-1008 1.7e-31 103.9 In-house 33-265 (281) alignment
Range on Protein: 773-1008
Range on HMM: 33-265/281.0
RLTANLAKNRYRDVCPYDDTRVTLQA----SPSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP
    |  |||| ..   | .|| |.       | ||| |||.     |  .   ||  |||   | .||| |.|..  |.||||  ..|  | || .|.|
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir....spflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

RVFET-QEYGRLMIKciKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFvdeVRKARQGSVdPIVVHCSAGIGRTGVLILMET
|      .. .| ..   .  | |       .      | | .|.  .  |||  ||.  . ...    .|| |  |  | |.|||||.||.| |. .| 
rnahcclqfdklsvs..yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlki...lrkirarst.ppvihcsagvgrsgtlmavei

AACLVESNEPVYPL-DIVRTMR-DQRAMLIQTPGQYTFVCESI
|   . |   .  . .||  .|   ||  .||  || .. . .
alqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 773-811 2e-06 21.6 In-house 35-75 (244) alignment
Range on Protein: 773-811
Range on HMM: 35-75/244.0
RLTANLAKNRYRDVCPYDDTRVTLQASP--SGDYINANYVN
 |.|| .|||| .. |.|.||| | .|   . |||||||..
vlsanatknryinilpfdetrvilssskkegsdyinanyiq

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 774-1013 1.7e-53 176.3 In-house 35-278 (287) alignment
Range on Protein: 774-1013
Range on HMM: 35-278/287.0
LTANLAKNRYRDVCPYDDTRVTLQASPS--GDYINANYVnmeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF
 .|.  |||| || |.||||| | | .    ||||||||    .|    ...||.|||.| |  ||| .|.|.. ......|   | .| ||..|||   
elaavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

ETQEYGRLMIKCI-KDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEV----RKARQGS-VDPIVVHCSAGIGRTGVLILM
     |   .  . .|..  . . | . . | .. | | | |.....|||....     .|.|| .|      ||..| | |.|||...||||.|.|. .
vPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

ETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
 .     |.   | .  .|  .| .|| |.|.. |. ...|..   |.
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 774-1007 9.5e-35 114.9 In-house 32-265 (285) alignment
Range on Protein: 774-1007
Range on HMM: 32-265/285.0
LTANLAKNRYRDVCPYDDTRVTLQASpSGDYINANYVNMeiPSSGiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPR-VFE
  ||   ||| ||   ..||| |.     ||| |... |  |     . ||. ||||  | |||| |..... . ..|| |. | |  ||  |.|  . |
yeanpdlnryadvrcieetrvvlknh.drdyihaswmrm..pgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

TQEYGRLMIKC--IKDKQTTNCCYREFSIRD--RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQgSVDPIVVHCSAGIGRTGVLILMETA
  ..|.  |     |..  .   .  ... .    |||   . ..|   |||.  |.| . .|..   |.|       ||.||||||.|||  .. .. |
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvgidya

ACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCES
.  .  |  .  ||||| ||  |   .|.  |. |.   
tirimenpniemldivremramrfqavqshmqflflyvv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 775-1019 8e-57 187.5 In-house 41-284 (515) alignment
Range on Protein: 775-1019
Range on HMM: 41-284/515.0
TANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYvnmeIPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPR-V
  |  ||||... ||| .|| |   . .|  ||.|| |    |||    . ||| |||.  . .||| .|.... |||.|.|   |  ..|| .|||   
einfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

FETQEYGRLMIKCIKDKQTTNCCYREFSIRdRNSSeERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAAC
 .. ..| . .. .  .  |.   |.. .  ...   | ||| ..  |||.||| . . ..... ||.  ..    |...|||||.|||||.| ..    
gdsvkfGsikvelvsleactggikrkltvl.kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvva

LVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH-DGTIKP
 ..  . |  ...|. .|..|  |.||  ||.|. . .|   .   |. |
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlip

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 775-1018 1.8e-30 100.8 In-house 31-264 (267) alignment
Range on Protein: 775-1018
Range on HMM: 31-264/267.0
TANLAKNRYRDVCPYDDTRVTLQASpSGDYINANYVNmeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITErGRVkcHQYW-PRVFET
. | ..||. |..||||||| |. .   .|||| ||.    .    | .|. |.||  | .||. .. .|....||.||.. . . .  ...| |.. ..
eknqernrlddnlpyddtrvilrtk.eeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkvft.dni..rlfwPPkmgqa

QEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEeRRVTQMQYIAWPDHgVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVE
..|  | ..   .|.  .     . .. .| |  . ||   |  |    . . |     |    ..  .    |.||.||.|.||.| .. ...    . 
kkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnin.tnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

SNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESiLRAYHDGTIK
 .. .   | .| .|.||  |..|  .| .. |. |  | .| .|
tegvsdifdflrkirsqriglvdtkeryiyihel.laeyaegrlk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 775-852 2.6e-06 21.2 In-house 35-116 (347) alignment
Range on Protein: 775-852
Range on HMM: 35-116/347.0
TANLAKNRYRDVCPYDDTRVTLQ--------ASPSGDYINANYVNMEIPSsgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVML
  .|.||| .||   |.||| |         | ..  |||| .....  |    . ||  | || .|  ||| ||   . | .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnas....keyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 776-1012 1.8e-55 183.2 In-house 50-284 (297) alignment
Range on Protein: 776-1012
Range on HMM: 50-284/297.0
ANLAKNRYRDVCPYDDTRVTLQA---SPSGDYINANYVNmeipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRvKCHQYWPRVFE
 |. |.||... |||  ||.|.    .|. ||.|| .|.      |. .|.|. | |   |  |||.||.... .|||||.   || . || .||.    
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk......gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

TQeYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPD--DPKHFIQFVDEVRKARQGSVD-PIVVHCSAGIGRTGVLILMETAA
|. .| . ..    .. .    ||....  ..  .| | | |.. |||. |.   . . ......||||  ..  . |..|||.||.||||||. ..   
tt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

CLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
. .. .. |  ...|. .|..|  |.||  ||.|| . .| | 
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 776-1010 2.6e-44 146.2 In-house 6-238 (239) alignment
Range on Protein: 776-1010
Range on HMM: 6-238/239.0
ANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvfE
 | ||||| ..  || .|| |.     |  |||||.|.       |  . ||| || .. .| ||| |.|...   ||||| . |  . |||||||    
vnkaknryanivtydhsrvvleklsndphsdyinasylrd...ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..s

TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLV
| .|  | .   | .  ..   | | . .   .||| | | ..  |||.|||.     . .  .. |       | |.|||||.|||| ......     
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
. .. |  .. |...|..|  ..||  || |.  ..| 
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 776-1009 4.8e-44 145.3 In-house 7-238 (239) alignment
Range on Protein: 776-1009
Range on HMM: 7-238/239.0
ANLAKNRYRDVCPYDDTRVTLQ---ASPSGDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvfE
 | ||||| ..  || .|| |.     |  |||||.|.       |  . ||| || .. .| ||| |.|...   ||||| . |  . |||||||    
vnkaknryanivtydhsrvvleklsndphsdyinasylrd...ydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..s

TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACLV
| .|  | .   | .  ..   | | . .   .||| | | ..  |||.|||.     . .  .. |       | |.|||||.|||| ......     
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
. .. |  .. |...|..|  ..||  || |.  ..|
kkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 776-1010 1.1e-41 137.5 In-house 54-287 (305) alignment
Range on Protein: 776-1010
Range on HMM: 54-287/305.0
ANLAKNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEIPSSgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQE
 . .||||.||   | . | |.  .  ||| ||||   .      .|.|..|||| .|  .|| || ...   ||||    | |..|| ||||     . 
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe...krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

ygRLMIKCI-KDKQTTNCCYR--EFSIRDRNS----SEERRVTQMQYIAWPDHGVPDDPKHFIqfvdEVRKARQGSVDPIVVHCSAGIGRTGVLILMETA
   |   .. ..   ..   |  |  |   |     ...  | ..|.  ||| |||      .    |.  | .||  |||||||||||||| .. .|  
..elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltsl....ellsairgskvpivvhcsagigrtgtivaieyi

ACLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFVCESILR
   .  | |. |. ..|...|||||. ||.  || |.   .| 
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln

subfamily_ptpA1_pd Subfamily ptpA1 776-963 1.4e-34 114.5 In-house 46-247 (418) alignment
Range on Protein: 776-963
Range on HMM: 46-247/418.0
ANLAKNRYRDVCPYDDTRVTL---QASPSGDYINANYVNMEIPssgivNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFE
 | .|||| .. | . ||| |   |     |||||||..   |     ...|. ||||  | .||| ||||..|  ||||.  .|  |.|| .|||    
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.....kqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

TQE----------YGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ---GSVD---PIVVHCSAGI
 ..          .|   .. ..  |  .       ||     | | .|| ||  |||| .||  . | |..  . . ..    | |   ||.||||||.
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGVLI
|||| . 
grtgtfc

Y_phosphatase Protein-tyrosine phosphatase 777-1009 1.3e-79 262.3 Pfam-A 1-234 (235) alignment
Range on Protein: 777-1009
Range on HMM: 1-234/235.0
NLAKNRYRDVCPYDDTRVTLQASPS-GDYINANYVNMEIpSsgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP-RVFETQ
|. ||||.|. |||.||| |. |..  ||||||||..   .    ...||.|||| .| .||| |||......|||||. .|.||.||.|||| .  |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGRLMIKCI-KDK-QTTNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACL
.||.. ...  | | ...... |.......... |.|.|.|..| .|||||||..||........|.| .. .  |.|||||||.||||........ . 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.|..| |  |.||...| ||....|.  || |... ||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 777-1009 1.3e-79 262.3 In-house 1-234 (235) alignment
Range on Protein: 777-1009
Range on HMM: 1-234/235.0
NLAKNRYRDVCPYDDTRVTLQASPS-GDYINANYVNMEIpSsgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP-RVFETQ
|. ||||.|. |||.||| |. |..  ||||||||..   .    ...||.|||| .| .||| |||......|||||. .|.||.||.|||| .  |..
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGRLMIKCI-KDK-QTTNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAACL
.||.. ...  | | ...... |.......... |.|.|.|..| .|||||||..||........|.| .. .  |.|||||||.||||........ . 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.|..| |  |.||...| ||....|.  || |... ||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 777-1009 2e-51 169.5 In-house 3-236 (237) alignment
Range on Protein: 777-1009
Range on HMM: 3-236/237.0
NLAKNRYRDVCPYDDTRVTLQASPS-GDYINANYVNMeipSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQE
| .|||| ..  || .|| |. . |  |||||.|..      |  ..|||.||||  .  ||| |||...|. ||||| . |. ..|||.|||   . . 
nkiknrygnivaydhsrvvlkgagsgsdyinatylkg...fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGRLMIKCIKDKQTTNCCYREFSIRDRNSSEE-RRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRK-ARQ-GSVDPIVVHCSAGIGRTGVLILMETAACLV
|| | .   |... ..   | . .  | . .| | . | |. .|||.|||.    ...|  .. . ..      | ..|||||.||||.......     
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
. .. |   . | .. ..|  .|||  || |. ..||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

0041856 (Phosphotyrosine protein) phosphatases II 777-1011 2.4e-48 159.5 In-house 1-170 (182) alignment
Range on Protein: 777-1011
Range on HMM: 1-170/182.0
NLAKNRYRDVCPYDDTRvtlqaspSGDYINANYVNMEIPSSGivnrYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTtitergrvkCHQYWPrvfetqey
|| ||||.|. ||| .|         ||||||.. .  |..     .||.|||| .|  ||. |..|...||||.||         ...|||        
nldknrysdilpydhsr.......dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

grlmikcikdkqttnccyrefsirdrnSSEERRVTQMQYIAWPDHGVPDdPKHFIQFVDEVRKarqgSVDPIVVHCSAGIGRTGVLILMEtaacLVESNE
                           . .|| ..| .|. |||||||| . ....|..||..    .  |..||||||.||||.|...     |.....
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaay....lmkklg

pVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
 | . ..|...| .| . ..|| || |.   .|  
.vsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 777-901 1.9e-24 81.0 In-house 47-184 (350) alignment
Range on Protein: 777-901
Range on HMM: 47-184/350.0
NLAKNRYRDVCPYDDTRVTLQ-----------ASPSGDYINANYVNMEIPSSGIVN--RYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKC
  |||||... ||. .|| |.           .  . |||||||.... .|  |    .||| |.||  |  ||. .. . . . |..||.  | .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYWPRVFETQEYGRLMIKCIKDKQTTNCCYREFSIRD
..||..    .   .|  |  .   . ..  . . .. 
yrYWqegsydditvklaskwenimgindsslysadvkk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 777-870 2e-12 41.1 In-house 48-156 (349) alignment
Range on Protein: 777-870
Range on HMM: 48-156/349.0
NLAKNRYRDVCPYDDTRVTLQASPS-----------------GDYINANYVNMeiPSSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERG
  |||||.|. ||. .|| |. |.                   |||||||...  .   . ..||| | ||  |  ||. ..  .    .. |.   | .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkl..trisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

RVKCHQYWPRV
  ||..||   
lekcdiywqel

subfamily_CG42327_pd Subfamily CG42327 779-940 8.2e-28 92.0 In-house 30-193 (319) alignment
Range on Protein: 779-940
Range on HMM: 30-193/319.0
AKNRYRDVCPYDDTRVTLQASPSG---DYINANYVNMEIPSsgiVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV---FE
 |.|. .| |  .|||.||  ..     |..|.||     .    | |||.| .|  .||||| .||||   .|| || . | |  .| .|.|      .
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda...pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

TQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYiAWPDHGVPDDPKHFIQFVDEVRKA
|. || ...   . .   .     . ..  . .| | .|   |  |.. .|| ... .|  . |||..
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 780-1003 1.1e-35 117.9 In-house 53-272 (301) alignment
Range on Protein: 780-1003
Range on HMM: 53-272/301.0
KNRYRDVCPYDDTRVTLQASPSGDYINANYVNMEipssGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFE-TQEYGR
|.||  |    .| | . .      | ||... .    |  .|.|| ||||  || |||.|.   .  .||||.   |.   ||..| |  .. . . ||
khryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

LMIKCIKDKQT--TNCCYREFSIRDRNSS-EERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqgSVDPIVVHCSAGIGRTGVLILMETAACLVESN
 .||  . ..    .   |.. ..|     . | ||  ||  |.|.|||    .  .... |.|    | .||||||||||||.  .|  |  |  ||..
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylarevead

EPVYPLDIVRTMRDQRAMLIQTPGQYTF
  .   . .. .|..|   .||  |  .
ptieltealkhlrehrwngvqtnsqlyw

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 780-1011 3.3e-27 90.0 In-house 46-275 (312) alignment
Range on Protein: 780-1011
Range on HMM: 46-275/312.0
KNRYRDVCPYDDTRVTLqASPSGDYINANYVNMeipsSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRV--FETQEYG
 ||| ..  .|  | || |     || ||.|..        .|....||||  |.. || ..    .|.|..|... | |  || .|   .  |   |  
lnrypniqcwdrgrftl.agdenfyihanfvki....ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

RLMIK-C----IKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQgsvdPIVVHCSAGIGRTGVLILMETAACLV
|.  . |    |  |   .  .| . .  . . .| .. . |. .|||||.||      ...  |.| ..    |.. |||||.|||| |.|.|.  . .
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk....pviahcsagvgrtgtlaliesmiaal

ESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRA
         |.   .| .||  ...  || ..  ..|  
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

0044763 (Phosphotyrosine protein) phosphatases II 788-1011 1.4e-35 118.0 In-house 1-170 (178) alignment
Range on Protein: 788-1011
Range on HMM: 1-170/178.0
PYDDTRVTLQASPS---GDYINANYVNmeiPSsgivnRYIACQGPlahtsSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFEtqeygrlmikci
|.|.||| |.  .    .|||||...    |       |.....|     .|.. ...|...|.||.||. .|.|..||..|||. ..            
pldrtrvllsnleglersdyinaseil...pg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

kdkqttnccyrefsirdrnsseerrvTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLIlmetAACLVESNePVYPLDIV
                           |...| .||||||| ..|| .||. ...|.. .  |..||||||.||.|.|.    || |. ..  . . ...
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlv....aaylmkkl.glsleeai

RTMRDQRAmLIQTPGQYTFVCESILRA
. .| .|   ...|||. ...|  || 
elvrerRp.ivpnpgqlrqLyefelrl

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 789-923 2.6e-09 31.5 In-house 5-126 (130) alignment
Range on Protein: 789-923
Range on HMM: 5-126/130.0
YDDTRVTlqaspSGDYINANYVNMeipsSGIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrvkcHQYWPRVFETQEYGRLMIKCIKDKQ
.. .|.        .||||..| .    .|  . |.  | ||| || ||| |. |..   .|.| .. |       .|||     . |   .|  . |..
fevsrlq.....gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

TTNC-CYREFSIRDRNSSEERRVTQMQYIAWPDHGV
  .     .. | .      . .| .|   ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 791-1009 2.3e-24 81.0 In-house 32-256 (290) alignment
Range on Protein: 791-1009
Range on HMM: 32-256/290.0
DTRVTLQAS---PSGDYINANYVNMeipSSGIvnRYIACQGPLAHT-------SSDFWVMVWEQHCTTIVMLTTITERGRV----KCHQYWPRVFE-TQE
.||| |.      . ||| ||.| .   ..|.  | |. | |....         .|| |. . . . .|||   .|. .      | .| |   .    
atrvvLkgygkrfnddyiHAnrvtc...pngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk

YGRLMIKCIKDKQTTNCCYREFSIRDrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqgSVDPIVVHCSAGIGRTGVLILMETAACLVE-S
.. | .|| .  .  .   ||  ..  .  ||  ||  ..  | .  |..|.| ... .. |..    |  |..|||  || |  .|  .. .  ..  .
fkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAalaaiilgyQkiaet

NEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
.. |   |.. ..| |||..|... ...||   |.
sgsvkledvlkalrkqralaitsalelafvdagiv

0043147 (Phosphotyrosine protein) phosphatases II 800-1005 2.6e-43 143.0 In-house 3-154 (172) alignment
Range on Protein: 800-1005
Range on HMM: 3-154/172.0
PSGDYINANYVNMEIpssgIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTItergrvkchqywprvfetqeygrlmikcikdkqttnccyrefsi
.. |||||.|... .    | .|.||.|||| .| .||| |..|...|.||.||.                                             
egsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel............................................

RDRNSSEERRVTQMQYIAWPDHGVPdDPKHFIQFVDEVRK--ARQGSvDPIVVHCSAGIGRTGVLILMETAAclvesnEPVYPLDIVRTMRDQRAMLIQT
    . .|| . | .|. ||||||| .......|.. ...  |.. .  |..||||||.||||.|...          . . ....|...|..| . .|.
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

PGQYTFVC
|.|| |..
psqyrfly

0051429 (Phosphotyrosine protein) phosphatases II 801-1011 3e-51 169.9 In-house 3-224 (272) alignment
Range on Protein: 801-1011
Range on HMM: 3-224/272.0
SGDYINANYVNMEiPSSGIVNRYIACQGPLAHTSSDFWVMvWEQHCTTIVMLTTITERGRVKCHQYWP-----------RVFETQEYGRLMIKCIKDKQT
 ..||||..|..   .  . .|.....||| .|  ||| . .|....|||.|.. .||||.||..|||           ....| .||.|...... ...
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

TNCCYREFSIRDR-NSSEERRVTQMQYIAWPDHGVPDDPkhFIQFVDEVRKarqgsVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVY--------P
... .||. ..   . .| |.|....|..|||||||...  ..........       |..||||||..|||.....   .  |. .  |         .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

LDIVRTMRDQRAMLIQTPGQYTFVCESILRA
...|. .|.||.  .||..|| |..| .| .
eeaveelraqrpgavqteeqylflyeallel

0046846 (Phosphotyrosine protein) phosphatases II 801-1007 2.1e-45 149.9 In-house 11-168 (176) alignment
Range on Protein: 801-1007
Range on HMM: 11-168/176.0
SGDYINANYVNMEipssgivnRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVFETQEygrlmikcikdkqttnccyrefsir
. ||||||.. .         |.||.|||| .|  ||. |..|...|..|.||. .| ||.||..|||.. . .                          
dldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

drnsseerrvtQMQYIAWPDHGVPDDpKHFIQFVDEVRKARQGSvDPIVVHCSAGIGRTGVLILMEtaacLVESNEPVYPLDIVRTMRDQRA-MLIQTPG
           | ... ||||||||. ..........|.|..    |..|||||||||||.|...     |.|..  . ........|.||  . .|||.
...........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYTFVCES
|| |. | 
Qyrflyef

0036282 (Phosphotyrosine protein) phosphatases II 802-1005 3.2e-47 155.8 In-house 2-163 (174) alignment
Range on Protein: 802-1005
Range on HMM: 2-163/174.0
GDYINANYVNMEIPSSgivnRYIACQGPLAhtssdFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRvfetqeygrlmikcikdkqttnccyrefsird
 |||||..... . ..    |.||.|||||     || |..|...||.|||..  |.|..||..|||.                                
sdyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

RNSSEERRVTQMQYIAWPDHGVPDDPKhFIQFVDEVRKARQG-SVDPIVVHCSAGIGRTGVLILMETAACLVEsNEPVYPLDIVRTMRDQRAMLIQTPGQ
. ...|| . | .|. ||||||||... ...||..|..|..  .  |..||||||.||||.|...    .. . . .|  ||.||..| || . .|||.|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YTFVC
| |. 
yrfly

0051082 (Phosphotyrosine protein) phosphatases II 802-1005 1.3e-31 104.6 In-house 3-146 (151) alignment
Range on Protein: 802-1005
Range on HMM: 3-146/151.0
GDYINANYVNmeipssgivNRYIACQGPLAhtssDFWVMVWEQHCTTIVMLTTITERGrvKCHQYWPRVFetqeygrlmikcikdkqttnccyrefsird
 ||||..||          .......||||    ||. ...|....|||.|.. .|||  .|..|.|.                                
sdyinfsyvt.........gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

rnsseeRRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKarqGSVDPIVVHCSAGIGRTGVLILMETAAcLVesnepVYPLDIVRTMRDQRAMLIQTPGQY
      ..|...... |||.|.|. .. ...|......    .  |..||||||.||||.|...   . |      | . .... .| .| ...|.. |.
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqf

TFVC
 |. 
lfql

0049260 (Phosphotyrosine protein) phosphatases II 818-1005 4.7e-42 138.6 In-house 6-143 (152) alignment
Range on Protein: 818-1005
Range on HMM: 6-143/152.0
GIVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWprvfetqeygrlmikcikdkqttnccyrefsirdrnsseerrvtQMQYIA
.  ...||.|||. .| .||| |..|...|||||||. .|.|..||.||.                                            | ... 
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlp

WPDHGVPDDPKHFIQFVDEVRKARQGSVDPIVVHCSAGIGRTGVLILMETAAclvesnEPVYPLDIVRTMRDQRAMLIQTPGQYTFVC
||||||||.. ....... ..|... .  |..||||||.||||.|...            | ....|. .| .| . ...|||. |. 
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 819-931 5.2e-09 30.1 In-house 135-242 (244) alignment
Range on Protein: 819-931
Range on HMM: 135-242/244.0
IVNRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrvkcHQYWPRVFETQEYGRLMIKCIKDKQ-TTNCCYREFSIRDRNSSEERRVTQMQYIA
    ||  | ||| || ||| |. |.|   .|.| .. |       .|||     . |   .   . |..   |    .. |        . .| .|   
rtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisn

WPDHGV-PDDpkHFI
||  |  |.|  |||
wpsdgttpnd..hfi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 821-1004 2.6e-17 57.6 In-house 4-195 (198) alignment
Range on Protein: 821-1004
Range on HMM: 4-195/198.0
NRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMI--KCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIA
 ||||.| || .| .||| ||||     |||.        .    ||| .   | .|| | .  |.|  |     .   ..         | ... |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDDpKHFIQFVD---EVR-KARQGSVDPIVVHCSAGIGRTGVLILMETAA-CLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFV
| ..  |.    |. ||    ||  |  |    |..|||| | | |||.. ..       ||.  |  | .. . .|. |  .| .  .| |.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 821-1004 2.8e-17 57.6 In-house 5-196 (199) alignment
Range on Protein: 821-1004
Range on HMM: 5-196/199.0
NRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMI--KCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIA
 ||||.| || .| .||| ||||     |||.        .    ||| .   | .|| | .  |.|  |     .   ..         | ... |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDDpKHFIQFVD---EVR-KARQGSVDPIVVHCSAGIGRTGVLILMETAA-CLVESNEPVYPL-DIVRTMRDQRAMLIQTPGQYTFV
| ..  |.    |. ||    ||  |  |    |..|||| | | |||.. ..       ||.  |  | .. . .|. |  .| .  .| |.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 821-871 8.3e-07 22.7 In-house 236-283 (440) alignment
Range on Protein: 821-871
Range on HMM: 236-283/440.0
NRYIACQGPLAHTSSDFWVMVWEQHCTTIVMLTTITERgrvKCHQYWPRVF
| .|| | ||  |  ||| .| . . .||.||  . ..    |  |||   
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvnt

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 829-1008 1.3e-17 58.3 In-house 99-284 (302) alignment
Range on Protein: 829-1008
Range on HMM: 99-284/302.0
PLAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWP-RVFETQEYGRLMIKCIK---------DKQTTNCCYREFSIRDRNSSEERRVTQMQYIAW
|   |   .| .. . . . .| |... | .  || .|.  .| .. ..||  .| ..         ||.. .    |.    ...  .. |  ... ||
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGVPDDPKHFIQFVDEVRkarqGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESI
|||| |..... .. .             ..||||||.|||| |. .     |   ..    |.||  .|. |   .|.  | ...   .
pdhGapkeaytaldilkfce....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv

subfamily_hpo-7_pd Subfamily hpo-7 830-1009 6.4e-15 49.8 In-house 43-224 (263) alignment
Range on Protein: 830-1009
Range on HMM: 43-224/263.0
LAHTSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMIKCIKDKQTTNCCYREFSIRDRNSSEERRVTQMQYIAWPDHGVPDDPK
|  |   |. ..  .  ...|||.  .| |..|| .|.|    | | .  . . . | .. .    .|.     .  . . |.. .|  |...  | ...
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelar

HFIQFVDEVRKARqgsvdPIVVHCSAGIGRTGVLILMETAAC-LV---ESNE--PVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
  .. .. .|. .     ..|||||.||||.    ..|..   ..   .  .   .  | ... .| .|.  |.|| |  |    .|
eilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvL

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 833-1009 1e-17 59.1 In-house 40-218 (255) alignment
Range on Protein: 833-1009
Range on HMM: 40-218/255.0
TSSDFWVMVWEQHCTTIVMLTTITERGRVKCHQYWPRVF-ETQEYGRLMIKCIKdkQTTNCCYREFSIRDRNS--SEERRVTQMQYIAWPDHGVPDDPKH
|   |. ..  .  ...|||.  .| |..||..|.|    | . .  . . . |   ...   |   |    .   . . |.  .|  |...  |.... 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FIQFVDEVRKARqgsvdPIVVHCSAGIGRTGVLILMETAAC-LV---ESNE--PVYPLDIVRTMRDQRAMLIQTPGQYTFVCESIL
  . .  ||...     ..|||||.||||.  ..|.| .   ..   .  |   .  | ... .| .|.  |.|| | .|    .|
ilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 877-1013 6.1e-18 59.3 In-house 62-195 (440) alignment
Range on Protein: 877-1013
Range on HMM: 62-195/440.0
GRLMIKCIKDKQTTNCCYREFsiRdrNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQ-GSVDPIVVHCSAGIGRTGVLILMETAACLVESN
 |.|.. .|    ..     .     |. | | . |..| .|||.|||      ......| ....  .  |..|||||| |||||.| ...    .. .
srvmleevkgvpdsdyinasy..i..ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrs

EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYH
. .  . .. .||..|  ..||| ||.|| |..| .  
dqidifsfinsmrnnrpqmvqtpeqyafvheavlegll

0048076 (Phosphotyrosine protein) phosphatases II 900-1006 1.1e-26 88.6 In-house 37-137 (145) alignment
Range on Protein: 900-1006
Range on HMM: 37-137/145.0
RDRNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSvDPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQRAMLIQTPG
 .  . .|| ..| .|. ||||||||.......|.. ...|..    |..||||||.||||.|.    ||.|. ..  | . .... .| || . ...||
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpg

QYTFVCE
|. |..|
qlrflye

0048179 (Phosphotyrosine protein) phosphatases II 902-1006 3.9e-25 83.7 In-house 41-139 (144) alignment
Range on Protein: 902-1006
Range on HMM: 41-139/144.0
RNSSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSvDPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQRAMLIQTPGQY
 . ..|| ..| ... ||||||||.......|.. ...|.. .  |..||||||.||||.|.    ||.|.  .  . . .... .| .| . ...|||.
epefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlv....aaylmkklg.lsleealalvrsrrpgavpnpgql

TFVCE
 |..|
rfLle

PTEN_1 903-1002 1.2e-10 36.5 In-house 85-183 (196) alignment
Range on Protein: 903-1002
Range on HMM: 85-183/196.0
NSSEERRVTQMQ--YIAWPDHGVPDDPKHFIQFVDEVRKARQGS-VDPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQR-AMLIQTP
 . ||..  ...   . ..|||.|.  ..|   ..    ... .    ..||| ||.||.|...    ||.|....    . . .. .|..| .. ...|
ydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppgapnsp

GQYT
 |  
sqer

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 904-969 4.7e-08 26.7 In-house 214-289 (349) alignment
Range on Protein: 904-969
Range on HMM: 214-289/349.0
SSEERRVTQMQYIAWPDHGVPDDPKHFIQFVDeVR-----------KARQGSVDPIVVHCSAGIGRTGVLILMETAA
...   . |.|.  |.| ..  .|. ..| .. |.              .  . ...|||||| ||||||. ..   
vekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlll

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 905-1009 1.9e-10 35.0 In-house 212-341 (350) alignment
Range on Protein: 905-1009
Range on HMM: 212-341/350.0
SEERRVTQMQYIAWPDHGVPDDPKHFIQFVD------EVRK----ARQGSVDPIVVHCSAGIGRTGVLILMETAAC-----------LVESNEPVYPLD-
|.   | |.|.  |.| ..  .|. ..| ..      .         .   .||.||||||.||||.|. ..                .... .    | 
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

---IVRTMRDQRAMLIQTPGQYTFVCESIL
   ||  .| ||  ..|.  |. |. |..|
isiivnelrkqrismvqnldqfifiYeall

0038934 (Phosphotyrosine protein) phosphatases II 909-1004 2.4e-11 39.1 In-house 78-169 (194) alignment
Range on Protein: 909-1004
Range on HMM: 78-169/194.0
RVTQMQYIAWPDHGVPD---DPKHFIQFVDEVRKARQGSvdPIVVHCSAGIGRTGVLIlmetAACLVESNEPvYPLDIVRTMRDQRAMLIQTPGQYTFV
.  .   . .||.|..      ..|...|||. .. .|    ..||| ||.||||.|.    || |....    . . ....|. |   |......  .
agieylklpfpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAialfrekRpgaipnqdyleal

PTPc_DSPc_SM00012 910-1009 1.5e-30 100.9 In-house 2-104 (105) alignment
Range on Protein: 910-1009
Range on HMM: 2-104/105.0
VTQMQYIAWPDHGVPDDPKHFIQFVDEVRKARQGSV--DPIVVHCSAGIGRTGVLILMETAACLVESN-EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCE
|....| .|||||||............|.| .. |    |.|||||||.||||........ . .|.. . |  ..||. .|.||. ..||  || |...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

SIL
 .|
all

subfamily_PTPDC1_pd Subfamily PTPDC1 913-1006 2.9e-09 31.6 In-house 85-170 (182) alignment
Range on Protein: 913-1006
Range on HMM: 85-170/182.0
MQYIAWPDHGVPDdPKHFIQFVDEVRKARQGSvdPIVVHCSAGIGRTGVLIlmetAACLVESNEpVYPLDIVRTMRDQRAMLIQTPGQYTFVCE
.  ..|.|.||.   .. .. |  |  | |     . ||| || |||||||    |. || ... . . . ....|..|.  ||| .|  .| |
vynfgwkDygvas.leriLdivkvvafalqeg..kvavhChaGlGrtGvli....acylvyakr.ltaekaiklvrskrpksiqtreqvelvke

subfamily_CG42327_pd Subfamily CG42327 938-1006 1.5e-10 35.3 In-house 240-309 (319) alignment
Range on Protein: 938-1006
Range on HMM: 240-309/319.0
RKARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESN-EPVYPLDIVRTMRDQRAMLIQTPGQYTFVCE
| ... |  |.||||| |.||||..|  . |   .| . . |   ..|  .| .||  ..|  || |.  
rsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 939-1010 3.6e-13 44.0 In-house 222-293 (297) alignment
Range on Protein: 939-1010
Range on HMM: 222-293/297.0
KARQGSVDPIVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILR
.| .    ...||||||.||.||..| .. .  .  .       |.. .|.|||.|.||  |.... . .|.
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 948-1012 1.8e-07 25.4 In-house 1-65 (69) alignment
Range on Protein: 948-1012
Range on HMM: 1-65/69.0
IVVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAY
.|||||.| |||| .| .      . |.  |  .. |. ||  | |..    .| |. ...  | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 949-1015 2.6e-07 24.9 In-house 1-67 (69) alignment
Range on Protein: 949-1015
Range on HMM: 1-67/69.0
VVHCSAGIGRTGVLILMETAACLVESNEPVYPLDIVRTMRDQRAMLIQTPGQYTFVCESILRAYHDG
|||||.| |||| .| .      . |.  |  .. |. ||  | |..    .| |. ...  |   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG