Gene ptp-3 in Caenorhabditis elegans

Synonym: CELE_C09D8.1, ptp-3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP161_AA protein Get Run
CeleP161_AA_1677-1952 phosphatase_domain Get Run
CeleP161_AA_1963-2242 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ig_3 Immunoglobulin domain 95-170 6.2e-09 27.9 Pfam-A 5-75 (75) alignment 
Range on Protein: 95-170
Range on HMM: 5-75/75.0
VVRPDSSTVVDESkISFFCRADGNP-LPSVIWRvngkSITDHNRISIKSLATGLSTLRFERVSLDDNATvVSCSADN
.| | ........ ... |.|.|.|  |.. |       |.... . ... .. ||| .. |. .|. | ..| | |
svspsptvtsggn.vtLtCsaeggpppptisWy....ietppelqgsegssssestLtissvtsedsGt.YtCvasN
Ig_2 Immunoglobulin domain 96-173 3.6e-07 22.1 Pfam-A 4-69 (80) alignment 
Range on Protein: 96-173
Range on HMM: 4-69/80.0
VRPDSSTVVDESKISFFCRADGNPLPSVIWRVNGKSITDHNRIsikslatgLSTlrfERVSLDDNATvVSCSADNGVA
 .. ...|   ... . |.|.||| |.|.|. .|. .. . ..        | .     ||..|. |  .|.| |.  
lsapptvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna........lfi...pnvsaedsGt.YtCrasnseg
I-set Immunoglobulin I-set domain 97-184 9.1e-11 33.4 Pfam-A 6-90 (90) alignment 
Range on Protein: 97-184
Range on HMM: 6-90/90.0
RPDSSTVVDESKISFFCRADGNPLPSVIWRVNGKSITDHNRISIKSLAtGLSTLRFERVSLDDNATvVSCSADNGvANPVVAEASLTV
.... .|  ...... |.. |.| ||| |  .|....  .|....    . .||....|. .|. .  .| | |  |  . |.|.|.|
klkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtvee.aeytLtIsnvevsDeGk.Ytckatns.agkaeakaeLkV
I-set Immunoglobulin I-set domain 195-282 2.5e-16 51.3 Pfam-A 1-86 (90) alignment 
Range on Protein: 195-282
Range on HMM: 1-86/90.0
PQIELHPSLKSVEQGKTAYVSCRVRGDPRAKVLWLRDliPLDIRADGRYSVSTIGNPGALMIQHAREEDQGKYECIARNTLGVAHSKA
|... ...   |..|...  .|.|.|.|  .| |..|    ... . |..|.  ..   |.|. ....|.|||.| |.| .| | .||
pkftqklkdvevseGesvelectveGepepsvsWakd..gselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeaka
Ig_2 Immunoglobulin domain 195-285 6.5e-09 27.7 Pfam-A 2-78 (80) alignment 
Range on Protein: 195-285
Range on HMM: 2-78/80.0
PQIELHPslKSVEQGKTAYVSCRVRGDPRAKVLWLRDlipldiraD--------GrysvstignpgaLMIQHAREEDQGKYECIARNTLGVAHSKAANL
|...  |   .|..|..  . |...|.| .|| | .|        .        .            | |... .||.|.|.| |.|. | . |.  ..
pvlsapp..tvvtegenvtLtCqapgnptpkvqwykd........geelsqsqna............lfipnvsaedsGtYtCrasnsegskqsnsvev
Ig_3 Immunoglobulin domain 303-364 3.8e-06 19.0 Pfam-A 9-73 (75) alignment 
Range on Protein: 303-364
Range on HMM: 9-73/75.0
QYVVGVGGNINLTCVAVGYP-MPRVFWKKTDLMVLDDPSTAPIGKNVLTLT--HVESTENFTCVA
. .| .|||..||| |.|.|  |.. |..   ..|. .    .. ..||..    | . ..||||
sptvtsggnvtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCva
Ig_2 Immunoglobulin domain 305-366 5.4e-06 18.4 Pfam-A 10-66 (80) alignment 
Range on Protein: 305-366
Range on HMM: 10-66/80.0
VVGVGGNINLTCVAVGYPMPRVFWKKTDlMVLDdpstapIGKN--VLTLTHVESTENFTCVAVS
||  | |..||| | | | |.| |.| .   |.       ..|   . ....|   ..||.|  
vvtegenvtLtCqapgnptpkvqwykdg.eels......qsqnalfipnvsaedsGtYtCrasn
fn3 Fibronectin type III domain 384-491 1.4e-10 34.3 Pfam-A 1-84 (85) alignment 
Range on Protein: 384-491
Range on HMM: 1-84/85.0
PPPVNIVVSSVTSESVVITWKPPK-YNEAINKYVVNYRLKSENKddaalfakdsraedesdserysegR--------SsrgktmetlENSLVIDGLVAFQ
..| |. ||.||| |....|.|||  .. | .| | || |....                                 .         ..|... || . .
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge........................ewkeftvprt.........ttsvtltgLkpgt

TYEFTVRSAGPVGVGLE
.|||.|..   .| | |
eYefrVqavngagegpe
FAM219A Protein family FAM219A 400-469 7.9e-07 15.9 Pfam-A 20-89 (125) alignment 
Range on Protein: 400-469
Range on HMM: 20-89/125.0
VITWKPPKYNEAINKYVVNYRLKSENKDDAALFAKDSRAEDESDSERY-SEGRSSRgKTMETLENSLVIDG
... .| | .  . |.   |  .|...|.. |.. || ...| . .|| |.|.||  .  . | . |. ||
avksqpkksakrsvkfnkgysalsqsadekplvsldsdsdeelelsrysssgyssa.qvnqdlsrqLlkDG
fn3 Fibronectin type III domain 507-593 2.1e-14 46.6 Pfam-A 2-85 (85) alignment 
Range on Protein: 507-593
Range on HMM: 2-85/85.0
APVSPQARSLNRDSILVKWGPCEQPNGLITGYKVYYTNDLVTTpirEWKQHDAKSDEFMTTINGLEPDSRYFVRVIAQNSEGDSPLS
||  ..... . .|. ..| | ....| ||||.| | ..  .    |||. ......   |..||.|...| .|| |.| .| .| |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 607-685 1.6e-15 50.2 Pfam-A 2-84 (85) alignment 
Range on Protein: 607-685
Range on HMM: 2-84/85.0
QPPMLTVKALDSRRMQLTWDKPL-YSSPVVGYTVRYNTSDGE---KELTLTSPHEKHVVTGLHPDKYYYFRVAAYSDRGQGEF
.|  |.|..  |. ..|.|..|   ..|..||.|.| ...|.   || |...... ...||| |.. | |||.|... |.|..
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
fn3 Fibronectin type III domain 700-806 2.1e-13 43.4 Pfam-A 1-85 (85) alignment 
Range on Protein: 700-806
Range on HMM: 1-85/85.0
SSPTIVSAAATSSKSVEIRWKGPEqkKLNGVLTAYRINYFRLEDSKtanlesveydedmddsssflDRMSVVVPSDATSYVLSDLLPYSSYEITVAASTM
|.|. .|. ...| |....|. |.  . .| .| |.. |   ....                    .  .. ||...||..|..| |...||..|.| . 
saPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge....................ewkeftvprtttsvtltgLkpgteYefrVqavng

DGYGPES
.|.||||
agegpeS
fn3 Fibronectin type III domain 819-911 1.8e-14 46.8 Pfam-A 1-85 (85) alignment 
Range on Protein: 819-911
Range on HMM: 1-85/85.0
SAPRNFNAELTSATSVKLTWDAPAAANGALLGYYVYLdRMVNGEPvvekgskKRIVMIRDSSKRYFELDSLDPNTEYSFRLNAFNRNGDGEFS
|||.|.... ...||. |.|..|.  .| . || | . |...|.        .     ...... ..|  | |.|||.||. | |..| |..|
saPenlsvsevtstsltlsWsppkdgggpitgYevey.rekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1038-1111 7.3e-06 19.2 Pfam-A 13-85 (85) alignment 
Range on Protein: 1038-1111
Range on HMM: 13-85/85.0
KGKIVVSWRPPSeeKRNGNITSYKAILSAMDATADRYEQPVPAPSTSSTF-EVNVRRAYLFKVAAATMKGIGPYS
  ....|| ||.  ...|.||.|.  .. .. . .  |. ||...|| |. . .  . | |.|.| . .| ||.|
stsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1126-1213 9.3e-11 34.9 Pfam-A 2-83 (85) alignment 
Range on Protein: 1126-1213
Range on HMM: 2-83/85.0
PPTNVRVEATSNSTAVVQWDFE---SQKADSFVVKYMHEPGNRmdtekwkqlPVVSIDKENPKRFAVVSDLNAHKPYAFCVLAVKNNRQGP
.|.|..|...........|.     ... ... |.| .. |..         . .... ..... .....|.....| |.| ||... .||
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge.........ewkeftvprtttsvtltgLkpgteYefrVqavngagegp
0050432 (Phosphotyrosine protein) phosphatases II 1655-1954 6.2e-105 346.2 In-house 6-302 (308) alignment 
Range on Protein: 1655-1954
Range on HMM: 6-302/308.0
VAIPSLPNNGNNMTTVSHPAVPIAELANHIERlrMNNNAGFQSEFESIETGQH-FTWEHSSADMNKHKNRYANVAAYDHSRVVLsnveGyPGMDYINANY
 |...|.  ... ..||.  ... .|....|.  .... ... ||| .   .  .......   ||.|||| .. .||||||.|    . .| |||||.|
dallelllfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsy

VDGY--DKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR---GTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVRE
||||  ..|| .||||||||.|. ||||||||... .|||||.|.|..|.||.||||.    |. .||.. ||||.  .|..||.||..|...|..|.|.
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrt

IKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNdaGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
..|..||.|||||||..|...| ||..|.. .|.  |||. |||||.||||.||..|..||.|.....||....|  || || .||||.|||.|...|.|
vthfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

DAVNSG
. ... 
eylklk
subfamily_PTPRA_pd Subfamily PTPRA 1671-1972 1e-102 338.4 In-house 10-316 (330) alignment 
Range on Protein: 1671-1972
Range on HMM: 10-316/330.0
SHPAVPIAELANHIERLRMNNNAGFQSEFESIETG-QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGP
 .. .|. .| . |..   ..|  |. ||... .|  . | | .| . ||.|||. |.  ||.|||.||..|| .  ||||| ..||| .  ..||.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

LPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLK----MVGEPEVREIKHLQYTAWPDHGVPDH
. ||  |||||.|| .| ||||||.|.|| . || ||||. |. |||.| |.. ... | .||.| . ..    .  | ..| .. . .|.||| ||| .
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

PTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQ
|   | .||.||.||.. ||||. |||||.||||.|||.| .|||.. .. ||... |  ||.||. ||||.||| ||. ..|.    | ||. .| | .
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

HLHILSQ
||. | .
hlqklyn
0039614 (Phosphotyrosine protein) phosphatases II 1671-1954 8.3e-97 319.5 In-house 10-292 (297) alignment 
Range on Protein: 1671-1954
Range on HMM: 10-292/297.0
SHPAVPIAELANHIERLRMNNNAGFQSEFESIETGQHfTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGY-PGMDYINANYVDGYDK-PRSYIATQG
... .|.  |. .. ....|.. ... |||..   ..  ....    ||.|||| .. .||||||.|. ..|. ...|||||.||||||. .| .|||||
esipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLPETFSDFWRMVWEEQSVTIVMLTNLEERSRvKCDQYWPSRGTaTYGDIEVTLLESVHLAHYTMRTMRLKMvgEPEVREIKHLQYTAWPDHGVPDHPTP
|||||. ||||||||... .|||||.|.|..| ||.||||..|. ||||. ||||.  ||..||.||.....  . |.|...|.||| |||||||.... 
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslel

FLIFLKRVKTLNPN--DAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSG
.| ||. |.. . .  . ||.. |||||.||||.||... |||.|..  .||.. .|  || ||...|||..||.|..||.|. .. .
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRD_pd Subfamily PTPRD 1672-1990 2.7e-159 526.4 In-house 2-321 (564) alignment 
Range on Protein: 1672-1990
Range on HMM: 2-321/564.0
HPAVPIAELANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLP
....|.|||..|...|..|... |..|...||.||.||||......||.||||||. ||||||||||.||| .|.|||||...|||.|...||||||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLI
||..||||||||..| ||||||.|||...|||..|||..||.|||...||| |...||.|..||..||.  . |.||... ..|.|||||||...|..| 
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILS
....|..||..|||||. |||||.||||.|||||.||||.....|||||..|.|||.|| .||||||||||||.|.|.|...|.|||....|.|||. |.
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

QPSAD-QLSGIDMEFRHLTT
. ..| . .|...||..|.|
eveedtemtgleleFqrLat
subfamily_PTPRK_pd Subfamily PTPRK 1672-1966 1.5e-107 354.1 In-house 1-292 (314) alignment 
Range on Protein: 1672-1966
Range on HMM: 1-292/314.0
HPAVPIAELANHIERLRMNNNAGFQSEFESIETGqhftWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLP
|||. .|.| ..|  |. ... ||. |.||.  |    |. .  | |..|||. .. |||.|||.|  ..| |  |||||...|.| .|. .|.|||||.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTAtYGDIEVTLLESVHLAHYTMRTMRLKM--VGEPEVREIKHLQYTAWPDHGVPDHPTPF
||  ||||.|..|.. .|||||.| | .|||| .|||  ..  ||||.|.|.|.  || . .|..|..    |  |.||....|...||||.|| . | .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQH
| ...|||. ....||.|. ||||| ||||.||.|| .|. .. ...||.. .| .||.... ||.|||||.||.|..|.|.  | | .|.|...  
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkal
0051299 (Phosphotyrosine protein) phosphatases II 1672-1950 5.5e-106 349.5 In-house 2-285 (288) alignment 
Range on Protein: 1672-1950
Range on HMM: 2-285/288.0
HPAVPIAELANHIERLRMNNNAGFQSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPL
. .... ||......|..|...|.. ||| .   . ..|. ...   |..|||| .. .||||||.||...|..| |||||.|.|||...| .|||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

PETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMV----GEPEVREIKHLQYTAWPDHGVPDHP
|.|..||||||||... .|||||.|.|..|.||.||||..|. ||||| ||||. ..|..||.||.... .    |. |.|...|..||.||||||||.|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

TPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
...| ||..|.. .... ||.. |||||.||||.||..|..||.|.. ..||... |  || || .||||.|||.|...|.|..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1672-1979 4.2e-93 306.7 In-house 3-307 (315) alignment 
Range on Protein: 1672-1979
Range on HMM: 3-307/315.0
HPAVPIAELANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLP
|  .|. .|  .. . . . . ||. ..|||  || .  . .   .||.|||| |. |||.||| |  .|  |. ||.|||..|||.|.| |||.|||..
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRgTATYGDIEVTLLESVHLAHYTMRTMrlKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLI
..  ||||.|.||.  .||||||| |. . |...||| .   .|| | ||. .  .  .||.||.   .| . ..||.  |.||.||| ||| . .|.. 
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmn

FLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILS
. ..||  . |..|.|. |||||.||||.|| .|..|...  .| .|.|  .| .|..|  |||. ||| ||.||.|...  | | .      |.   | 
lirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsll

QPSADQLS
 || |  |
apspdtgs
subfamily_Ptp69D_pd Subfamily Ptp69D 1673-1969 3.3e-84 277.6 In-house 2-304 (307) alignment 
Range on Protein: 1673-1969
Range on HMM: 2-304/307.0
PAVPIAELANHIERLRMNNNAGFQSEFESIE-TGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLP
.|..| .|.. ..  . . . |.. |.|..| .  . . . |  . |. |||| .. |.|. ||.|....|    |||||... ||.. ...|| |.|. 
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVG-----EPEVREIKHLQYTAWPDHGVPDHP
.|  |||||..| .. .||||.||.| .| ||..|||   .  |||| |.| .. .  .|..|.. . ...     ... |..   .||.|.|  ||...
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQH
.  | ....|. |. .. .||. ||||| ||.| |. .| .|..|. ...|||.  |  || ||. .||  |||.|.. |.||  . | |..    |...
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

LHI
.. 
ier
subfamily_PTPRB_pd Subfamily PTPRB 1674-1955 2.7e-105 346.6 In-house 6-289 (293) alignment 
Range on Protein: 1674-1955
Range on HMM: 6-289/293.0
AVPIAELANHIERLRMNNNAGFQSEFESIET-GQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPE
 . . ....|..... .....|. |.|.... |.. . . ... .|. |||| |. .|||||| |..... .| |||||||..||  || .|||||||||
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR-GTATYGDIEVTLLESVHLAHYTMRTMRLKMvgEPEVREIKHLQYTAWPDHGVPDHPTPFLI
|. ||||||||..| .|||||.| |. .|||..|||.   . .||||.|||... .| ....|.....   | | |.......|.|||||||......| 
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FLKRVKTLN--PNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGS
|...|..     ....||. |||||.||||.|| .| .|.... ...|||.| |..|| .| ..||||.||||||..||| .....
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1675-1987 1.2e-123 407.3 In-house 2-317 (318) alignment 
Range on Protein: 1675-1987
Range on HMM: 2-317/318.0
VPIAELANHIERLRMNNNAGFQSEFESI-ETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPET
... .|..|..|||.. .  ...|.| .  . ...|. .|  ..||.||||||. ||||.|| |...|| .| |||||||.||| . ..|||.|.|||||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFL
..|||||||| .| .|||||..|||...|...||||.|. .||.. |.| |.|.|..|..|.....  .| |.|...  .||.|||.|||.... .| ..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

KRVKTLN-PNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILSQ
..|.. . ...||||. |||||.|||| ||..| .|||.. ...||... |. || ||  |||||.||.||.|..|.|..|| ||| || |..... | .
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

PSADQL-SGIDMEFRH
.....  . .|.||..
qdpesgttemdaefqr
subfamily_PTPRG_pd Subfamily PTPRG 1675-1965 2.4e-112 371.0 In-house 1-301 (563) alignment 
Range on Protein: 1675-1965
Range on HMM: 1-301/563.0
VPIAELANHIERLRMNNNAGFQSEFESIET---GQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGM-DYINANYVDGYDKPRSYIATQGPL
||. |.|.|.  |  ... ||. |||....    .... |||..  ||.|||| |. |||.||| ||.. |  .  |||||||.||| | . .|||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

PETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKM-----VGE-PEVREIKHLQYTAWPDHGVPD
..|| |||||.||... .|||.|||.|| | |||.|||. .. ||| ..||| |. .|| ||.||. .|        .  ....... .|| |||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLH
|..| ||| |. .. |...||||. |||||.|||| .||.| .|.... .|.|...| .  .|||| ..|||||||||.|||.|.|..|. ||. |....
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

Q
.
e
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1675-1977 7.9e-112 368.4 In-house 5-309 (319) alignment 
Range on Protein: 1675-1977
Range on HMM: 5-309/319.0
VPIAELANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETF
....||......|. . . ... ||. ..... .|....| . ||.|||| |. |||..|||||...| .| |||||...|||.. . .||||.|| .|.
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

SDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMV-GEPEVREIKHLQYTAWPDHGVPDHPTPFLIFL
.|||||||||.| ..||||.| |. .||. .|||.    .|| . |||.|  .|..| .| . |.   .| | ||.|| |||.||||.||.. |  | .|
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

KRVKTLNPN-DAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILSQ
||..    . ..|||. |||||.||||.|||.| ||||.. ....|..  |  ||.||  |||..|||.||..|.|.||..|.||.    |.. |. |..
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlae

PSADQ
  || 
kvadt
0043336 (Phosphotyrosine protein) phosphatases II 1675-1949 2.3e-100 330.9 In-house 2-275 (278) alignment 
Range on Protein: 1675-1949
Range on HMM: 2-275/278.0
VPIAELANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETF
... .|......| .|...... |||.. . ...|....    ||.|||| .. .||||||.||...| ...|||||.|||||..|| .||||||||||.
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

SDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPsRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLK
 ||||||||... ||||||.|.|..||||.|||| .|. ||||. ||||.  ||..||.||..... |..|.|.. |..|..|||||||......| |||
edFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

RVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
.|.. .... ||.. |||||.||||.||... .||.|..  .||.. .|  || ||  .|||..||.|...|.|.
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 1675-1950 2.5e-94 311.7 In-house 9-303 (307) alignment 
Range on Protein: 1675-1950
Range on HMM: 9-303/307.0
VPIAELANHIERLRMNNNAGFQSEFESIETGQHF---TWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGY-PGMDYINANYV--------DGYDKPRS
...  |  .. .|  ....|.. |||..   ..|   ......   ||.|||| .. .|||.||.||...|  .. |||||.||        ||||..| 
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

YIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTA-TYGDIEVTLLESVHLAHYTMRTMRLKMV-GEPEVREIKHLQYTAWPDH
.||||||||||. |||||.||... .|||||.|.|. |.||.||||. |.  |||.. ||||.  ||..||.||.....  |. |.|...|..||.||||
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

GVPDHPTPFLIFLKRVKTLNPN--DAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNT---VDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
|||... ..| |...|.. . .  . ||.. |||||.||||.||... ||..|....|   ||.. .|  ||.||. .||..|||.|...|.|. 
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1675-1971 5.4e-76 250.4 In-house 3-297 (315) alignment 
Range on Protein: 1675-1971
Range on HMM: 3-297/315.0
VPIAELANHIERLRmnNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETF
.|.|..   ... |  . | |  ||  .   . .    .  ..| .|||| |.  .|..||.|  ..  |  ||||| |. ..|. ..|||.||||. . 
ipvaqfpafvnknr..htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasv

SDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPS--RGTATYGDIEVTLLESVHLAHYTMRTMrlKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIF
.||||||..|.  ||||.|...|  ..|| ||||     .. .| |.|.||.    .  ..| .   .    | | .   |.| |||.||. . . .| .
ddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllkl

LKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILS
.| ||. | ..  ... |||||.|||| .| || ......  ..||..  |. |||.| |.|||||.| ||.||||. .    | ..  .. .||. | 
ikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1675-1971 6.8e-74 243.9 In-house 5-308 (325) alignment 
Range on Protein: 1675-1971
Range on HMM: 5-308/325.0
VPIAELANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETF
. . .| .|.|. . ... ||  ||. . . .  . . .    || |||. || |.|.|||||   .  |  |||||.|.  . |   ..|.| ||..| 
iavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

SDFWRMVWEEQSVTIVMLTNLeERSRVKCDQYWPSR--GTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIF
 |.||.| . ..  .|.|  | .    .| .||| .   . |.| .|| |    ... | .| . .| | . | | .| .|. .|.| ||. .|. .. .
ndlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LKRVKTL------NPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQH
|. ||..      | . ..||. |||||.||||.|| . ..|...  .  |||.| |  ||..|  ||.| .|||.|..|. .|. || |.|| | .. .
lqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeak

LHILS
|  | 
lsslq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1675-1955 1.1e-73 242.7 In-house 2-287 (290) alignment 
Range on Protein: 1675-1955
Range on HMM: 2-287/290.0
VPIAELANHIERLRMNNNAGFQSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPG--MDYINANYVDGYDKPRSYIATQGPLP
.|. .......  ....| ||...|.....|. ..| ..  .  ||..||.||.  ||  |..| .. | .    .|||| |..|| . ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGE-PEVREIKHLQYTAWPDHG-VPDHPTPF
.|  |||...|.|..  ||||||  |  .||| ||||...|..|| ....||.  .| .|. |....|   .  . ......| |.|...| |... |  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGS
|.. ...||   .  ..|. |||...||.. |....  ... . .  .|..  .  .| |.  .|||..|| .|.. || ...| .
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1675-1958 1.1e-68 226.3 In-house 2-285 (287) alignment 
Range on Protein: 1675-1958
Range on HMM: 2-285/287.0
VPIAELANHIERLRMNNNAGFQSEFESIET--GQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEgypgMDYINANYVDGYDKPRSYIATQGPLPE
.|. .... ... . ..| ||.  |  .|    ..    |. |  ||.|||....  .|  ||.| . .     ||||| ..||| . . .|....|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgeh....pdyinavfidgykekkafiiaesPmfn

TFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVG-EPEVREIKHLQYTAWPDHG-VPDHPTPFL
|  .||.......  .||||....|  . .| ||||.  . ..|. ...||.  . |.|..|....|  . . . ...|  |.|.|...| |... | .|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

IFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEV
.. ...||   .  ..|. |||...||.. |. ..  ... . . ..|..  .   | |.  .||| |||.|| |.||  ..|..| .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1675-1962 1e-67 223.3 In-house 10-295 (297) alignment 
Range on Protein: 1675-1962
Range on HMM: 10-295/297.0
VPIAELANHIERLRMNnnAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKprSYIATQGPLPETF
.|....|  ... |      |. ||  . . . ..   .   .| .|.||.|.  || ||| |  |.  |  ||.|| .| |. .   .|.|| | ..| 
iplsdfatlvqknrht..dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatv

SDFWRMVWEEQSVTIVMLTNLEERSRvKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPD--HPTPFLIF
 |||.||..||  |||||....|| . || .||. .|..|.||. |.||   .   .  |.. ..       | .|  |.. |||. |.   . . .| .
adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllkl

LKRVKTL-NPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASR
.. |.   . |  ||.. ||.||.|||| .. || .. . . ...|||.| |. || .| |.|||.||| |.. |||.|. |  |...|| 
isevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1675-1975 1.1e-59 196.8 In-house 4-260 (392) alignment 
Range on Protein: 1675-1975
Range on HMM: 4-260/392.0
VPIAELANHIERLRmnNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETF
.|.|..   .|. |   .| | .||  .   . .    .  ..|..|||| |.  || .||.|  ..  |  ||.|| |....|  ..|||.||| . ..
ipvaqfpafveknr..hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

SDFWRMVWEEQSVTIVMLTNLEERSrvkcdqywpsrgtatygdievtllesvhlahytmrtmrlkmvGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLK
.||||||..|.  ||.|.|.|.|                                               ..| .   ..| |||..|| | . .| |.|
ddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfik

RVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILSQPS
 ||.   . . |.| |||||.||||  | ||... . .    ||..  || .| .| |||||.||| ||. |||. .    | .|  .. .||..||  |
evkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstss

A
 
d
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1676-1966 3.7e-88 290.6 In-house 5-298 (305) alignment 
Range on Protein: 1676-1966
Range on HMM: 5-298/305.0
PIAELANHIERLRMNNNAGFQSEFESIETGqHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFS
 ...||..|.  |.... |.. ...|. .  . . .  . ..||.|||....  .|..|. |.. |  .  |||||.|||||..  .||..||||..| .
alddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntva

DFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTA--TYGDIEVTLLESVHLAHYTMRTMRLKM-VGEPEVREIKHLQYTAWPDHGVPDHPTPFLIF
||||...||. .||||||.| |  . || |||| . |    .|...|.| .. . . |..| ... .  .. | | . ..| | |||||||. .| .| .
dfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllsl

LKRVKTLNPNDAG-PIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQH
.|||.    .| | |.. |||||.||||.||..| .||||. ...||... . .|| .| .|||| .|| |.|||. . ...| |..  | |. .
ikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrar
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1677-1757 5.2e-12 39.8 In-house 8-86 (440) alignment 
Range on Protein: 1677-1757
Range on HMM: 8-86/440.0
IAELANHIERLRMnnNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGY
.|..|....  |      |. |.  . .|     . .|   || |||| |. |||||||.| .|.| |  ||||| |..| 
vadfadyvqnnrr..srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_PTPN9_pd Subfamily PTPN9 1678-1949 1.4e-85 282.0 In-house 4-288 (297) alignment 
Range on Protein: 1678-1949
Range on HMM: 4-288/297.0
AELANHIERlrmNNNAGFQSEFESIETG-QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSD
 || ....    ... | . |.. |     . | ..|   .| .||||..|  ||..||||..|.. .  ||||||.|||| .....|||||||..|.||
eelvayvke...kgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP--SRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLK
|||||||.. ..||| | ..|| |.|| ||||  .  .| .||..|. .| ..  .|..|.. .| | . | |.. | |...|||.|||.  . .| .|.
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

RVK--------TLNPNDA-----GPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
 |.        .| ....      ||. ||||||||||.|| .|  |.||.  .|||.  .|  ||.||....||.||| | . |||.
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1678-1963 1.2e-73 243.1 In-house 5-291 (439) alignment 
Range on Protein: 1678-1963
Range on HMM: 5-291/439.0
AELANHIERLRMNNNAGFQSEFESIETGQH-FTWE--HSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETF
 |. .|.|.|  |..  |. .||.|.. .  .. .    . . .. |||| .|.|.||.||.| .. | |   ||||||..|| ... |||||||  || 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

SDFWRMVWEEQSVTIVMLTNLEERSRvkcdqYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGE--PEVREIKHLQYTAWPDHGVPDHPTPFLIF
 ||||.|.|...||||||||| |  .     |||| . . |||| |     . | .|..| ...    .     | . ...|.||||. || . .  | |
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

LKRVKTLNP-NDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRL
|. ... |  .. ||.. |||||.||||. | .|  ||.|. .| ||| | |. || ||  |||.  ||.||..|||. .  | . |   ..
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
0040438 (Phosphotyrosine protein) phosphatases II 1680-1972 6.2e-107 352.8 In-house 5-297 (317) alignment 
Range on Protein: 1680-1972
Range on HMM: 5-297/317.0
LANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWR
| .....| .... ....||| . . .. |.....   ||.|||| ..  ||||||.||...|... |||||.||||....| .||||||||.|. ||||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTL
||||... .|||||.|||..|.||.||||...| ||||. ||||. ..||..|.||....  |..|.|...|..||.|||||||..|...| ||..|.. 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

NPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILSQ
.... ||.. |||||.||||.||....|||.|.. ..||.. .|  ||.||...|||.|||.|..||.|. .. . | .|||.|. .|. | .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1680-1953 2.8e-92 303.8 In-house 2-278 (281) alignment 
Range on Protein: 1680-1953
Range on HMM: 2-278/281.0
LANHIERLRMNNNAGFQSEFESIET-GQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFW
| .|...|. |.||||..|.|...  |.. | . | || |..|||| |. |||..||.... |     ||||||.|.||.... |||||||.|... .||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG-TATYGDIEVTLLESVHLAHYTMRTMRLkMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRV-
.||||..  .|||.|.  | ...|| .|||    . .|||. |. ... . |.|  |...|    . | ||...|.||||||||||. .. .| | | | 
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl

KTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYD-NTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNS
|. ...   |.. |||||.||||..| .| .....  . ...|.   |. || .| .||||  || |.. |||||.. 
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1680-1768 2.6e-14 47.2 In-house 10-95 (95) alignment 
Range on Protein: 1680-1768
Range on HMM: 10-95/95.0
LANHIERLRMNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEgypGMDYINANYVDGYDKPRSYIATQG
.  |.  .  | .  |. || ||      ..   |.. |  |||. |.  || .||||.        ||||| .|||| .   |||.||
fhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1682-1953 2.1e-93 307.5 In-house 10-282 (288) alignment 
Range on Protein: 1682-1953
Range on HMM: 10-282/288.0
NHIERLRMNNNAGFQSEFESI-ETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRM
... .   .|..||..|..|. . ... . . ..   |..|||| |. .||. || | ..|  .| |||||.|.||..| . ||||||||..|  |||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEEQSVTIVMLTNLEERSRVKCDQYWPSRGT-ATYGDIEVTLLESVHLAHYTMRTMRLKmvGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTL
|.|... ||||||.| |. . ||..|||. ..   ||...|||.|| .| ....|.. |.   . . .||...||.||||||||.  .|.| .|. ||. 
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkva

NPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVN-S
|..|.|||| |||||.|||| ||..|....... ....|. | |. || ||  .|||..||.||....|. ..  
nqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPN23_pd Subfamily PTPN23 1682-1952 4.7e-67 220.8 In-house 4-281 (288) alignment 
Range on Protein: 1682-1952
Range on HMM: 4-281/288.0
NHIERLRMNNNAGFQSEFESIETGQHFTWEHSS---ADMNKHKNRYANVAAYDHSRVVLSnvegYPGMDYINANYVDGYD-KPRSYIATQGPLPETFSDF
....|  ........ .|. .|. |.   .. |   | .. .|||. ..  |||.||.|         ||||| .| .      ..||||.||..| .||
eelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG--TATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKR
|.||.|..| .||||.. ||. . |.|.|||..   | ..||..||| .  .. ..  |...|.. .. .|....|||.|.||..|||. |  .| ||. 
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VKT----LNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNT-VDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVN
|..     . .   |.. |||||.||||.| .. . .. |. .|  .||   |  ||.|| .|||..||. |  .||| |..
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1685-1958 4.8e-102 336.2 In-house 19-297 (298) alignment 
Range on Protein: 1685-1958
Range on HMM: 19-297/298.0
ERLRMNNNAGFQSEFESIETGQH----FTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRM
.  . .. .|...||. ......    ...| .... ||.|||||.. |.|.|||||.....    ||||| ....|..  ..||||.||.||..|||||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrm

VWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTlN
|.||.. ||||||||||  ..|. .|||..|..|||.|.|.||.. . | ...|.. ..   | . ||...|..| |||.||| . |  | .|..|.. .
vteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.s

PNDAG--PIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEV
...||  |.| .||||.||.|.||.|| .|||.. ...||..  | .||..|  .|||||||.||..|||.|..|...|.
qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0036941 (Phosphotyrosine protein) phosphatases II 1687-1962 1.3e-97 321.9 In-house 7-288 (297) alignment 
Range on Protein: 1687-1962
Range on HMM: 7-288/297.0
LRMNNNAGFQSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLsnveGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQ
 .....|....|||..   .  .......   |..|||| .. .|||.||.|    . .| |||||.|||||| .| .||||||||.|. ||||||||..
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

SVTIVMLTNLEERSRVKCDQYWPSR--GTATYGDIEVTLLESVH--LAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNP
. .|||||.|.|. |.||.||||.   .. ||||. ||||.  .  |..||.||......|..|.|...|..|| |||||||..|...| |...|.. ..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

N--DAGPIISHCSAGIGRTGAFIVIDCMLERLR---YDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASR
.  . ||.. |||||.||.|.||..|.||..|.   . ..|||. .|  || ||  .|||.|||.|...|.|. .... | .|...
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1687-1963 1.2e-63 209.6 In-house 3-278 (283) alignment 
Range on Protein: 1687-1963
Range on HMM: 3-278/283.0
LRMNNNAGFQSEFESIETGQHFTwEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGypgmDYINANYVD---GYDKPRSYIATQGPLPETFSDFWRMVWE
|| |||  |.  .. .   .  . . .||| ||.|||. .. ..|  || | .       ||||| ..     |.. . ||..|.|| .|  |||.||..
lrvnnnklfrevlkrlsvpdlda.diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

EQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVG--EPEVReIKHLQYTAWPDHGvPDHPTPFLIFLKRVKTLNP
|. ..|||||.| |  |.|| ||||.||.  ||.  ||| . .    .... . |.. .  . ..  . | |.  | . | .. .   |. . .|..|  
ekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleyg.eqaiinslvkfnkvislqt

N-DAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRL
.   |||. |||.|||||..|| . . .. .. .  ||..  |. .| ||  .||| .|| ..|..||.    | |.. |  |
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_PTPN6_pd Subfamily PTPN6 1688-1951 3.2e-85 280.8 In-house 21-297 (306) alignment 
Range on Protein: 1688-1951
Range on HMM: 21-297/306.0
RMNNNAGFQSEFESI---ETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSnVEGYPGMDYINANYVDG--YDKPRSYIATQGPLPETFSDFWRMVW
 . ..|||. |||..   |. . .. ....   ||.|||| |.  .||.||.|.  .. || |||||||...   .. .||||||| |..| ||||||||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

EEQSVTIVMLTNLEERSRVKCDQYWPSRGT-ATYGDIEVTLLESVHLAHYTMRTMRLK-MVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTL-
.|.|  |||.|.  ||.. || .|||.  .  .||.|.|| ... .||.|..|..... .  . | ||. ......||||||| .|  .| ||. |..  
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

---NPNDAGPIISHCSAGIGRTGAFIVIDCMLERLR---YDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
   . ..||||. ||||||||||.|||||..|. ..   .|  .||. .|  .|.||| .||||.|| |.. |.   .
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1688-1948 1.3e-56 186.5 In-house 7-274 (287) alignment 
Range on Protein: 1688-1948
Range on HMM: 7-274/287.0
RMNNnaGFQSEFESIE---TGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNvEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEE
|...    . |.. .     .  .|.  .   .. .|||||.|  .|..||.||. ||  | |||||||| .| .  ..||.|||.. |  ||||.|.|.
rvkd..dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravlet

QSVTIVMLTNLEERSRVKCDQYWPSRGTA-TYGDIEVTLLESVHL-AHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRV-----K
.| .....|   | .| || .||| |      |   |.||.   .  .|..|..||  .   | | .| |.. .|||....     .. |   |      
rsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

TLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
. . ...||.. |...||||.| .. .  ...||     ||.   |  || .|  .||.  |. .. .|. 
ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0047943 (Phosphotyrosine protein) phosphatases II 1689-1949 8.3e-96 315.9 In-house 8-270 (273) alignment 
Range on Protein: 1689-1949
Range on HMM: 8-270/273.0
MNNNAGFQSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLsnveGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSV
........ ||| .   . ..|.....   ||.|||| .. .||||||.|    | .| |||||.|||||...| .||||||||.|. ||||||||... 
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

TIVMLTNLEERSRVKCDQYWPSRG---TATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPN--
.|||||.|.|..|.||.||||. |   . |||.. ||||.  . ..||.||..|...| .|.|...|..|| |||||||......| |.. |.. . .  
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

DAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
. ||.. |||||.||||.||..|..|..|.. ..||.. .|  || || .||||.|||.|...|.|.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1689-1954 4.8e-56 184.7 In-house 11-296 (301) alignment 
Range on Protein: 1689-1954
Range on HMM: 11-296/301.0
MNNNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEG--YPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQS
.... .|.........|.. . . .  ..||. ||. |.. ||. |..|.. .       .||||.|.||| . . .||.|||. .|  ||||..|.|. 
akhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

VTIVMLTNLEERSRVKCDQYWPS--RGTATYGDIEVTLLESVHLAHYTMRTMRLKMVG---------------EPEVREIKHLQYTAWPDHGV-PDHPTP
|.|||.|||.|... || ||||.    . ..| ..||| ..  .  ...| . .|.                 . . ...  || | ||..|| ... | 
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

FLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSG
  .  . ... .  . ||.. |||....|.| .. ..  ||  . .  ||... . |.| ..  .|.| |||..|.|..   ..  
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1690-1950 3.1e-41 136.1 In-house 19-286 (305) alignment 
Range on Protein: 1690-1950
Range on HMM: 19-286/305.0
NNNAGFQSEFESIETGQHFTWEHSSADM-NKHKNRYANVAAYDHSRVVLsnvE-GYPgMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSV
.  ||...|| ...  . |   ..  .  ...|||| .|   |. || |   |  .|  .|| ||||    .|. .| || || .| .||| | ....  
kgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkve

TIVMLTNLEERSRVKCDQYWPSRGTATY----G--DIEVTLLESVHLAHY-----TMRTMRLKMVGE-PEVREIKHLQYTAWPDHGVPDHPTPFLIFLKR
.| || || |.   || .|..|.   .     .   | | .  || |        ...   | . |   ..| ..|  .  ||| |||   .  | .|..
aifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek

VKTLNpndaGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDI-YGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
 ...     |||. ||||||||||. .... .|..|   . ..     .  .| ||   .||..||.|.|. .|. 
arpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1691-1972 1.3e-74 246.1 In-house 16-297 (515) alignment 
Range on Protein: 1691-1972
Range on HMM: 16-297/515.0
NNAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIV
. . |  ||  .   . .    .  ..| .|||| |.  || .|| |  ..  |  ||.|| |. ..|  ..|||.|||.. . .||||.|..|.  ||.
httlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttia

MLTNLEERSRVKCDQYWPS--RGTATYGDIEVTLLESVHLAHYTMRTMrlKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPII
|.|.|.|  ..|| .|||     .  .| |.| |.     .  . |..  ... . ..| .   ..| |||.||| | . .| ..| ||. . . . |.|
mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkl..tvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

SHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILSQ
 |||||.|||| .| || .. . .  ..||..  || .|..| |.|||.||| ||..|||. .    | .|   . .||  |  
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhs
subfamily_PTPRN_pd Subfamily PTPRN 1691-1952 1.1e-58 193.4 In-house 27-293 (297) alignment 
Range on Protein: 1691-1952
Range on HMM: 27-293/297.0
NNAGFQSEFESIETG--QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYD-KPRSYIATQGPLPETFSDFWRMVWEEQSV
|.  .. |.|.. .   .  | | ..|. | .|||...| .|||||| |..       |||||  .   | .  .||||||||..| .|||.||||. .|
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLL-ESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGP
 ||.||.||| .  .|..|||  |...|.  || |. | .    | .|.. || .   | | .  . . .||..|||  . ..| | ..|       . |
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

IISHCSAGIGRTGAFIVIDCMLERLR-YDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVN
|. |||.| ||||..|.|| .|.||    . .||   .  || ||. .|.|..|. |.  || . ||
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1692-1949 1.6e-45 150.2 In-house 5-257 (267) alignment 
Range on Protein: 1692-1949
Range on HMM: 5-257/267.0
NAGFQSEFESIETGQ--HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYpgmdYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTI
.  .. ||| |.     . |   | |  |. .||. ..  ||..||.|.. |      |||| ||.|| . . .|.||.||  | .||. .. ...  .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLTNLEERsrvKCDQYWPSR-GT-ATYGDIEVTLLESVHLAHYTMRTMRLKMVGEpEVREIKHLQYTAWPDHgVPDHPTPFLIFLKRVKTLNPNDAGPI
|.||.  .    .  ..|| . |    | |. |          | . |. ||.  |   ...    |  |    . ..|    .|    |    |   |.
vlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnin.tnnkpylkplfgilaknqlengnrPl

ISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
. .||.|.||.|.|.||| .|||.. ....||.  .  .| ||  .|.| |.||.||. . .
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1692-1948 4.3e-19 63.1 In-house 25-282 (302) alignment 
Range on Protein: 1692-1948
Range on HMM: 25-282/302.0
NAGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGypgmDYINANYVDGYDKPRSYIATQGPLPETF---SDFWRMVWEEQSVT
.|  ..||..|.| .  . . ..   | .||.  .| ..|. .| |.. .     .|.||  |.  .  || | .| |  ..     .|||||..|. |.
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

IVMLTNLEERSRvKCDQYWP--SRGTATYGDIEVTLLEsVHLAHYTMRTMRLKMV----GEPEVREIKHLqyTAWPDHGVPDHPTPFLIFLKRV--KTLN
.|.|   || ..   ....|  |    .||.. |     |  |. .     . ..     .  . ....|  | |... ||.. .      . |  |. .
vvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkik

PNDAGPIISHcsAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
 ..   |.|.   |.|| |||..    .|.|  .. . |   |...|.||. .|.. .||.... |.|
adentvivSk..nGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_CG7180_pd Subfamily CG7180 1693-1951 2.5e-61 201.9 In-house 17-290 (296) alignment 
Range on Protein: 1693-1951
Range on HMM: 17-290/296.0
AGFQSEFESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVML
. .. |.. ... .  .  .     |. |||. .|  ||. ||||....|    ||||| |||.. |.. || |..|  ||  .|||.|..|.. ..|.|
veyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvL

TNLEERSRvKCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMV----------GEPEVREIKHLQYTAWPD-HGVPDHPTPFLIFLKRVKTLNP
|.  . .. .. .||| .. . ||.|.| ..|. ..|. ..||..|.             . |.| .|..|.| |.  . ||   . .. ...||...  
tktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre

ND-----AGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
.       ||.. ..| | .|.|... ||  || .. .. ||... |  || .|  .|.. |.| .| | .|.||
kvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0046845 (Phosphotyrosine protein) phosphatases II 1695-1956 2.9e-98 324.0 In-house 2-279 (284) alignment 
Range on Protein: 1695-1956
Range on HMM: 2-279/284.0
FQSEFESIETGQHF---TWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGY-PGMDYINANYVDGY-----DKPRSYIATQGPLPETFSDFWRMVWEEQ
.. ||| .   ...   ..... .  |..|||| .. .||||||.|....|  .. |||||.|||||     .... .||||||||.|. ||||||||..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SVTIVMLTNLEERSRVKCDQYWPSRG-TATYGDIEVTLLESVHLAHYTMRTMRLKMVG-EPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNP--
. .|||||.|.|..|.||.||||. | . ||||. ||||.  .  .||.||..|...| . |.|...|..||.|||||||..|...| ||. |..|..  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

NDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDN---TVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGST
.. |||. |||||.||||.||..|..||.|....   .||....|  || || .||||.|||.|...|.|...... |
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
DSPc_SM00195 1695-1951 1.4e-92 305.1 In-house 2-262 (263) alignment 
Range on Protein: 1695-1951
Range on HMM: 2-262/263.0
FQSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLT
.. |||..|. . . . ...  . ||.|||| |.  |||.|| |.. |. .| |||||||..|..|...|||||||||.|..|||||||||.. .|||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLEERSRVKCDQYWPSR--GTATYGDIEVTLLESVHLA-HYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISH
. ||. . |||.|||.   |. |.|.|.|.| |  .   ....||..|.. |. | |.....||..||||||||.....| .|. ||. . .  |||. |
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
||||.||||.|..||..|..|. ...|||  .|..|| ||  ||||.|||.||..|.|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1695-1951 1.4e-92 305.1 In-house 2-262 (263) alignment 
Range on Protein: 1695-1951
Range on HMM: 2-262/263.0
FQSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLT
.. |||..|. . . . ...  . ||.|||| |.  |||.|| |.. |. .| |||||||..|..|...|||||||||.|..|||||||||.. .|||||
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLEERSRVKCDQYWPSR--GTATYGDIEVTLLESVHLA-HYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISH
. ||. . |||.|||.   |. |.|.|.|.| |  .   ....||..|.. |. | |.....||..||||||||.....| .|. ||. . .  |||. |
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
||||.||||.|..||..|..|. ...|||  .|..|| ||  ||||.|||.||..|.|...
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN14_pd Subfamily PTPN14 1695-1952 1.9e-61 202.7 In-house 25-297 (300) alignment 
Range on Protein: 1695-1952
Range on HMM: 25-297/300.0
FQSEFESIETG-QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYpGMDYINANYVDG--YDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVM
   |.| |    .. . . .. . |..|||. .|  |...|| ||  .     .||||  .      | ||||..||||. |  |||.||||..   |||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LTNLEERSRVKCDQYWPSR----GTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNP------
||. ||  . |. .|.|.      |...|  .||   | .   .. ....|| .   | |.. ||||| |||||||. ...|| .|..|. .        
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

---NDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVN
   .   |.. |||||.||||  |. | ... |  ....||   .. || || ..|||  || |......  ..
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN1_pd Subfamily PTPN1 1696-1951 4.6e-66 217.5 In-house 9-271 (290) alignment 
Range on Protein: 1696-1951
Range on HMM: 9-271/290.0
QSEFESIETGQ-HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGypgmDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTN
.. .. |.    .|. ...  . |. .||| .|  |||||..| . .     |||||. |.  .  |||| ||||||.| . ||.||||..| ..||| .
keiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

LEERSRVKCDQYWPSRGT---ATYG--DIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTL--NPNDAGPI
. |....|| ||||.       ..    ..|.|..  .  .||.|...|. .   | ||| |  ||.||| |||. |. || || .|.      .| || 
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

ISHCSAGIGRTGAFIVIDCMLERLRY-D--NTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
. ||||||||.|.|...|..| ..   |  ..|||   . .|| .|  ..|| .|  | . |.|. .
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1699-1960 3.5e-39 129.2 In-house 33-298 (310) alignment 
Range on Protein: 1699-1960
Range on HMM: 33-298/310.0
FESIETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSnVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEER
.  ... |  .  . .   . |||||..|   | ||| |  ..     ||| ||||       ..| .||||  |  |||||...|.. .|..| .  | 
yrkldakqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgee

SRVKCDQYWPSRG-TATYGDIEVTLLE-SVhlAHYTMRTMRLKMV-------GEP-EVRE--IKHLQYTAWPDHGVPDHPTPFLifLKrvKTLNPNDAGP
 | ||  |||| | | ||| | || |  |     . .  . . .|        .| ...|  .. ...  ||| ||||     .   .  . |     ||
grpkcvgywpslgvtetygcirvtnlsess..eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv..pq..rllaqvrhgp

IISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLdAVNSGSTEVPA
 . |||||..|... . ..  ...|.  . ||.   .| |. .|   .||| ||..|.   . .   | |||  
cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevae
0045098 (Phosphotyrosine protein) phosphatases II 1702-1951 1.1e-85 282.6 In-house 17-272 (278) alignment 
Range on Protein: 1702-1951
Range on HMM: 17-272/278.0
IETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVlsnvegypgmDYINANYVDGYdkPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRV
. .|.  .....    |..|||| .. .||||||.          |||||.|.|||  |. .||||||||.|..|||||.||... .|||||.|.|..|.
lllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

KCDQYWPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKMV----GEPEVREIKHLQYTAWPDHGVPDHP--TPFLIFLKRVKTLNPN-------------
||.||||..|. ||||..||||.  .| .||.||...  .     . | |...||.|. |||||||..|  ..|| .|....  . .             
kcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

DAGPIISHCSAGIGRTGAFIVIDCMLERLryDNTVDIYGCVTALRAQRSY-MVQTEEQYIFIHDAVLDAV
. ||.. |||||.||||.......|||.|  ...||.. .|. || || . .||..|||.|.....|. .
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN12_pd Subfamily PTPN12 1702-1953 8.1e-78 256.2 In-house 24-279 (290) alignment 
Range on Protein: 1702-1953
Range on HMM: 24-279/290.0
IETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRV
  . . .. |..... |..|||| ..  ||.|||.||. |. .| ||||||.. | ... .|||.|||||.| .|||||.|| .   .||. .. |  . 
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCDQYWPSRGT--ATYGDIEVTLLESVHLA-HYTMRTMRLKMVgePEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRT
||..|||..|    ..|..|||| |  ..   ...||.....    | |... ..||||||||||  ... | ... |..|. ... |.. |||||.|||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GAFIVIDCMLERLRYDNT---VDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNS
|. |.|| . | |. ...   .|..  |. || ||. .|||.||| ... ||.. |..
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_egg_pd Subfamily egg 1703-1948 7.2e-33 108.6 In-house 25-267 (307) alignment 
Range on Protein: 1703-1948
Range on HMM: 25-267/307.0
ETGQHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERsrVK
|. .. . ... .| |..| |   |   | ||| |   .|    |.| ||.|.|      .| .| || .|  ||||||..|.   |||||   |    .
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CDQYWPSRG--TATY--GDIEVTLLESVHLAHYTMRTMRLKMVGEPevREIKHLQYTAWPDHGVPDHPTPFLIfLKRVKtlnpNDAGPIISHCSAGIGRT
|. |||     .. .  | .... |.  . |   .|  .||.||    .| ..|..  .  . . |  .|. . |....    | . |.. ..  |. ..
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssdvysplrv.lrklr....nlskpvvvqdilGvska

GAFIVIDCMLERLRYDNT--VDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
.... |.  |  |    .    .  .|  || .| . |..  .|.|..  ||
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1706-1757 1.3e-06 22.2 In-house 27-77 (244) alignment 
Range on Protein: 1706-1757
Range on HMM: 27-77/244.0
QHFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEgYPGMDYINANYVDGY
..|    .    |  |||| |.  .|..||.||. .   | |||||||..| 
reflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgs
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1707-1966 1.5e-78 259.4 In-house 50-306 (319) alignment 
Range on Protein: 1707-1966
Range on HMM: 50-306/319.0
HFTWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTnleersRVKCDQY
  . ...  | || |||. |. |.|...| | ...|  . ||||| .|.|| ..  |||.||||..|  |||||.|| .. |||.||      . || ||
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSRGTATYGDIEVTLLESVHLAHYTMRTMRLKM-VGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNP--NDAGPIISHCSAGIGRTGAFIV
|| ..  ...  .| .      | |..| ..|     | ..|.|.   .  |||.||||.|.... ..|.|. |.   |.  .|. |||||.||||..||
wplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

IDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQH
.|..|.|.. .. ||.|  |  || ||. .||   || ||. |.|.    | ..|    .  .
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay
subfamily_ptpA1_pd Subfamily ptpA1 1707-1912 2.6e-48 159.8 In-house 37-257 (418) alignment 
Range on Protein: 1707-1912
Range on HMM: 37-257/418.0
HFTWEhSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYdKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQY
  | |      |  ||||.|.   .|.|| | ...   | |||||||.||   |. .|.||||||.| .||||||||..   ||||.   |  |.|||.|
setse.gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

WPSR-----------GTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVK----TLNPN--DAGPIIS
|| .           |   .|   | |.| ..     . |  ...  | | |.| . ||  |||| .|||  ||  .|. .      . |.     ||| 
wpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGIGRTGAFIVIDCMLERLR
|||||.||||.|     |...| 
hcsagvgrtgtfctavimmkkld
0049772 (Phosphotyrosine protein) phosphatases II 1708-1953 2.3e-45 151.0 In-house 36-282 (314) alignment 
Range on Protein: 1708-1953
Range on HMM: 36-282/314.0
FTWEHSSADMNKHKNRYANVAAYDhSRVVLsNVEGYPGMDYINANYVDGYdkpRSYIATQGPLPETFSDF----------WRMV--WEEQSVTIVM----
.|.  ..  .|..|||| ..  .| .||.| . ... |.|||||.||||.   ...|||||||..|. ||          ||||  .. .. .|||    
ltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------LTNLEERSrvkcdQYWPSRGTATYGdievtllesvhlahytmrtmrlkM-V--GEPEVREIKHLQYTAWPDHGVPdHPTPFLI
                 |..| ..       ... .  ...                          .  .|   |.. .. .. .||...|  .  |. 
vladelsrLdaAlgKtpllildgng.....neptaadlellk.......................eelydpelferlgikylripvpDgsap.lledfde

FLKRVKTLnpNDAGPIISHCSAGIGRTGAFIVIDCMLERLRydntVDIYGCVTALRAQRS-----YMVQTEEQYIFIHDAVLDAVNS
||. ....  .. ||.. ||.||.|||| |.|..... .|.    |..  ..  .|..|.      .... |||.||..|.|.... 
flefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealleylkf
0040439 (Phosphotyrosine protein) phosphatases II 1709-1951 1.6e-88 291.7 In-house 2-246 (249) alignment 
Range on Protein: 1709-1951
Range on HMM: 2-246/249.0
TWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP
......   ||.|||| .. .||||||.|| ..|... |||||.|.|||. .| .||||||||||..|||||.||... .|||||.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SRGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPN--DAGPIISHCSAGIGRTGAFIVIDC
..|. .|||. ||||.  ....||.||..|......|.|...|.||| |||||||... ..| |...|.. . .  . ||.. |||||.||||.||... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
|||.|.. ..||.. .|  || ||...||..|||.|...|.|. .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1709-1971 1.6e-77 255.8 In-house 16-275 (284) alignment 
Range on Protein: 1709-1971
Range on HMM: 16-275/284.0
TWEHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTnleersRVKCDQYWP
. ...  | || |||. .. |.|...| | .. |  . ||||| .. || ..  ||||||||..|  |||||.|| .. |||.||      . || ||||
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywp

SRGTATYGDIEVTLLESVHLAHYTMRTMRLKM-VGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNP--NDAGPIISHCSAGIGRTGAFIVID
 ..  ...  .| .      . |..| ..|     | ..|.|.   .  |||.||||.|.... ..|.|. |.   |.  .|. |||||.||||..||.|
lkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

CMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPASRLHQHLHILS
..|.|.. .. ||.|  |  || ||. .||   || ||. |.|.    | ..|    .  .|. ||
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1709-1948 8.1e-75 246.4 In-house 19-265 (274) alignment 
Range on Protein: 1709-1948
Range on HMM: 19-265/274.0
TWEHSSADMNKHKNRYANVAAYDHSRVVLSNVE-GYPGMDYINANYVDGYDK-PRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQY
. |. .   ...|||| ..   ..|||.|.. .   .  .||||||. |||.  . |.|||||||.| .|||||...|..  |||||.|.|. . || .|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPSRGTA----TYGDIEVTLLESVHLAHYTMRTMRLKMVGEpeVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPN---DAGPIISHCSAGIGRTG
.| .  .    .|||.|..  . |.  .|..|.. || . .   |..||  ||.|||| .||.....| ... |.. . .    ..|.. ||||||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

AFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
.|| |.  . .|| ...||. . |. || .|  ||||.||| .|| |. 
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
0037934 (Phosphotyrosine protein) phosphatases II 1710-1948 7.5e-81 266.5 In-house 2-239 (243) alignment 
Range on Protein: 1710-1948
Range on HMM: 2-239/243.0
WEHSSADMNKHKNRYANVAAYDHSRVVLsnvegyPGMDYINANYVDGYDKprsYIATQGPLPETFSD----FWRMVWEEQSVTIVMLTNLEERSRVKCDQ
. ...  .|..|||| .. .||||||.|      .| ||||||.......   .||||||||||. |    ||||.||... .|||||.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsrGTATYGDIEVTLLESVHLAHYTMRTMRLKMVG-EPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTL--------NPNDAGPIISHCSAGIG
|||  |. ||||..||||.. ||..||.||..|.... ....|.. |..|..||||||||.|...| ||. |..         . .. ||.. |||||.|
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGAFIVIDCMLERLrydnTVDIYGCVTALRAQRSY-MVQTEEQYIFIHDAVL
|||..|... ||..|    .||.. .|  ||.||.. .|||..||.|...|.|
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1710-1950 3e-50 165.5 In-house 46-282 (290) alignment 
Range on Protein: 1710-1950
Range on HMM: 46-282/290.0
WEHSSADMNK--HKNRYANVAAYDHSRVVLSnvEGYPGmDYINANYVDGYDKPrsYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYW
 | .  | |   .|||| .|.  | .||.|.  .||.| ||. ||||.| . .  .| |||.| .|  |.|||| .|.  .|||| .| |  . ||.||.
lerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyy

PSRG--TATYGDIEVTLLES-VHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLnpndAGPIISHCSAGIGRTGAFIVI
| .   . |.|.| |.  |.  . |.  ..|. .. . .     .|||.  .|||. |.     .|  |. ....    .||.. ||||||||||.|. |
pekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvai

DCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
.  |. |     .|. . | |||  |   || . ||. . ...|| 
evglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1710-1949 2.5e-41 136.3 In-house 47-287 (305) alignment 
Range on Protein: 1710-1949
Range on HMM: 47-287/305.0
WEHSSADMNKHKNRYANVAAYDHSRVVLSNVEgypGMDYINANYVDGYDKP-RSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP
    |||... ||||..| . |.| | |..       ||| ||||     | . .|..|||| .|  .|| || ...   |||| .  |  ..|| ||||
nanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

SRGTATYGDIEVTLLESVHLAH-------YTMRTMRLKMVGEPEVrEIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTlnpnDAGPIISHCSAGIGRTGAF
             ..| |  ..         . ...| . |. ..  ..|||.| ||| |||      | .|  ..        ||. ||||||||||. 
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkm.svrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgti

IVIDCMLERLRYDNT-VDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
. |. .||..  ..    .   | ||| ||.. .|.. ||.|||  .|.
vaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
0042113 (Phosphotyrosine protein) phosphatases II 1711-1950 1.2e-87 288.7 In-house 2-242 (245) alignment 
Range on Protein: 1711-1950
Range on HMM: 2-242/245.0
EHSSADMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR
....   ||.|||| .. .|||.||.||...| .. |||||.|||||. .. .||||||||||. |||||.||... ||||||..||..||||.||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNP-NDAGPIISHCSAGIGRTGAFIVIDCMLE
.. ||||. ||||.  ||..||.||......|..|.||. |..|. ||||||||..  .| ||..|..    .. ||.. |||||.||||.||... |||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
.|..  .|... .|  || ||. .|||..||.|...|.|. 
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPN13_pd Subfamily PTPN13 1711-1951 1.1e-72 239.6 In-house 30-269 (273) alignment 
Range on Protein: 1711-1951
Range on HMM: 30-269/273.0
EHSSADMNKHKNRYANVAAYDHSRVVLSNVEGypgmdYINANYVDG--YDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP
| .  . ||.|||| ||  ||..|| |..  |     ||||...     ..  .|||.||||||| .|||.|||| ..  |.|.|.  |. .|||..|||
evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP

SRG---TATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPnDAGPIISHCSAGIGRTGAFIVID
..    .  .. .||.||. ..|  ...|.. .| .   |.||. ||....||||||| .....| |...|..|.  |||||. ||||||||.|..|.||
esknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitid

CMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
 .|. .  |. .|.   |  || ||  .|||..||||.. |.|...
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1711-1942 8.4e-35 115.0 In-house 43-272 (301) alignment 
Range on Protein: 1711-1942
Range on HMM: 43-272/301.0
EHSSADMNKHKNRYANVAAYDHSRV-VLSNVEGYPgmdyINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPS
..| | ..|.|.|| .|    .. | |... .  |    | ||...   .|. .|||||||..|  ||| |.   .  .||||..  |.   ||..| |.
tesyaylpkdkhryptvPckPstavevivdGkrvP....ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

RGTATY--G--DIEVTLLESVHLAHYTMRTMRLK-MVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKtlnpNDAGPIISHCSAGIGRTGAFIVI
. . .   |  .|...  |..   . . ||....   |. . | . | ||. |.|.|||   .    ... ||    .   ||. ||||||||. |||  
kisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigt

DCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIF
...  ..  |.|...   .  || .|   |||..|  .
eylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_PTPN3_pd Subfamily PTPN3 1712-1952 1.5e-73 242.1 In-house 35-276 (280) alignment 
Range on Protein: 1712-1952
Range on HMM: 35-276/280.0
HSSADMNKHKNRYANVAAYDHSRVVLSNVEGypgmDYINANYVD----GYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYW
..    | .|||| ....||. || |.. |     ||||||||.    . .    ||||||||..| .|||.||||..| .|||||.| || |||| |||
aarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PSRG-TATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDC
|. . . .||...|.. .. .   | .| . ||   . | |.| .|||.|||||||||... || |..||..|   .  |.. |||||||||| .|... 
PetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlillet

MLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVN
 |  .   . | .   |  .| ||. .|||..|| |. .|.| . .
alalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1713-1864 2.2e-35 117.0 In-house 26-181 (297) alignment 
Range on Protein: 1713-1864
Range on HMM: 26-181/297.0
SSADMNK--HKNRYANVAAYDHSRVVLSNVegYPGMDYINANYVDGYDKP--RSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP
|||  |   .|||| .. |.| .|| | .|   .. |||||.||   |..    || .|||| .|  |||..|.|..  .|||...|.|  | ||  |||
ssakrnsslrknryrdilatddtrvkllrv..iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

S--RGTATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPD
|   .  . ||. |  | |.   . ..    |...   | | ..| |. .||||||| 
svvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1714-1949 7.6e-49 161.4 In-house 37-275 (307) alignment 
Range on Protein: 1714-1949
Range on HMM: 37-275/307.0
SADMNKHKNRYANVAAYDHSRVVLSnVEGYpGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG--
. . | .|||| .| . |..|.|.  ..|    ||| |||.    ||. .|..|||| .|  .|| |. .|.  ...|| .. | ...||.||||     
afsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegq

TATYGD----IEVTLLESVHLAH--YTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKtlnpNDAGPIISHCSAGIGRTGAFIVID
. ..|.    | |. | . .||     .    ||..   . | |.|||.. |||.|||.     . .|. |.     |  |.. |||||.||.|. . | 
klvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtnpvvvhcsaGvGrsGtivais

CMLERL-RYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
 . ... .  |  |.   |  ||.|| | .||| ||...|  .|.
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1714-1948 1.3e-38 127.6 In-house 31-267 (285) alignment 
Range on Protein: 1714-1948
Range on HMM: 31-267/285.0
SADMNKHKNRYANVAAYDHSRVVLSNVEgypgMDYINANYVDGYDKPR-SYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG-
. . |   ||||.| . . .|||| | .     ||| |...    | . .||.||||||||.||||.|...|.   ..||  | |    ||  |.| .  
ayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

-TATYGDIEVTLLESVHLAHYTMRTMRLKMV----GEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAgPIISHCSAGIGRTGAFIVIDC
    .|  |.|| |    |        | ..       |   ..|.|   |||.  |.   |.. . | || .||..  ||  |||||.||| .|. || 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidy

MLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
   |.  .  ...   |  .|| |   ||.  |..|..  ..
atirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1714-1824 4.9e-15 49.7 In-house 44-167 (349) alignment 
Range on Protein: 1714-1824
Range on HMM: 44-167/349.0
SADMNKHKNRYANVAAYDHSRVVLSN--------------VEGYPGMDYINANYVD--GYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEE
.      |||| ..  |.||||.| .               ..    |||||||.    ..  . ||||| ||| |  ||....  ..   .. |.. .|
eGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke

RSRVKCDQYWPSrgtATYGDIEVTLLE
 |  |||.||      .| .|.| | .
lslekcdiywqe...lsysnitvklqn
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1716-1949 3.4e-71 234.2 In-house 6-239 (239) alignment 
Range on Protein: 1716-1949
Range on HMM: 6-239/239.0
DMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYD-KPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSrGTAT
 .|| ||||||. .|||||||| ..   |  |||||.|.  ||  |..|||||| .  .  |||||.|.|. . ||||| | |  . || ||||   |. 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stsk

YGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYD
| .. ||| ..  .| | .||. .  ||. | | . . ..| |||.|||.. |  | . ...   .   | | . |||||.||||||.|||.|| . . .
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkq

NTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
.||||.  | |.| .| .|||| |||.||| |||.
ktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1716-1949 7.9e-41 134.6 In-house 35-267 (281) alignment 
Range on Protein: 1716-1949
Range on HMM: 35-267/281.0
DMNKHKNRYANVAAYDHSRVVLSN-VEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTA-
 .|..||||.|. . | ||| |   .      ||| |||.      | || ||||  || .|||||.|.|.. .|||| .. |  | || .|.|    . 
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

-TYGDIEVTLLESVhlAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTlnpNDAGPIIsHCSAGIGRTGAFIVIDCMLERLR
  .  . |.  .|      .. | ||..  | | | | |  .  |||  ||.    .|  |.....     . |.| |||||.||.|... ..  |. ..
lqfdklsvsyedst..vnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira...rstppvi.hcsagvgrsgtlmaveialqsih

YDNTV-DIYGCVTALRA-QRSYMVQTEEQYIFIHDAVLD
   |. ||   |. ||   |.  ||| .||..|   .||
shftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1716-1791 1.2e-09 32.2 In-house 35-115 (347) alignment 
Range on Protein: 1716-1791
Range on HMM: 35-115/347.0
DMNKHKNRYANVAAYDHSRVVLSNVE-----GYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVM
. .  |||  .|   | .|||||  .       .   |||| ..   .  . || || |||.|  |||.||   .   .| 
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1716-1809 8.3e-07 22.1 In-house 25-86 (169) alignment 
Range on Protein: 1716-1809
Range on HMM: 25-86/169.0
DMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINAnyvdgydkprsyiatqgplpetfsdfwRMVWEEQSVTIVMLTNLEERsrvkcDQYWPS
  |. ||| |   |  | || |  |    | |||||                           ||.|| ..  ||.| . ...     ...|| 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpe
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1716-1799 1.6e-06 21.1 In-house 24-80 (169) alignment 
Range on Protein: 1716-1799
Range on HMM: 24-80/169.0
DMNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINAnyvdgydkprsyiatqgplpetfsdfwRMVWEEQSVTIVMLTNLEERS
  |. ||| |   |  | || |  |    | |||||                           ||.|| ..  ||.| . ... 
tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddkn
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1717-1953 2e-90 297.4 In-house 8-244 (250) alignment 
Range on Protein: 1717-1953
Range on HMM: 8-244/250.0
MNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVkCDQYWPSRGTATYG
 ||.|||||.. |.|.||||| ...|    ||||| ...|||. ...|||||||..|. ||||||.||.| ||||||||.|  .. . ||||  .. .||
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

DIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPN-DAGPIISHCSAGIGRTGAFIVIDCMLERLRYDN
|. |.||.. . | ||.|.. |    . . | ...|....||| |||.. |  | .||.|.. ... ...|.| .||||.||.||||.||..||||. ..
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

TVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNS
.||..  . .||..|  .|...|||.|.. ..| |..|
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1717-1950 1.5e-71 235.3 In-house 6-239 (239) alignment 
Range on Protein: 1717-1950
Range on HMM: 6-239/239.0
MNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYD-KPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSrGTATY
.|| ||||||. .|||||||| ..   |  |||||.|.  ||  |..|||||| .  .  |||||.|.|. . ||||| | |  . || ||||   |. |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stsky

GDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDN
 .. ||| ..  .| | .||. .  ||. | | . . ..| |||.|||.. |  | . ...   .   | | . |||||.||||||.|||.|| . . ..
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

TVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
||||.  | |.| .| .|||| |||.||| |||.|
tvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1717-1950 2.3e-65 215.3 In-house 19-263 (270) alignment 
Range on Protein: 1717-1950
Range on HMM: 19-263/270.0
MNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYD-KPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGT---
 .|. ||||..    ..||.|...|  .   ||||||| |.| ....|||..|||| | ..||||.|||.. .|||.|.|||. | ||..|||..     
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

-ATYGDIEVTLLESVHLAHYTMRTMRLKMVGEpeVREIKHLQYTAWPDHGVPDHPT------PFLIFLKRVKTLN--PNDAGPIISHCSAGIGRTGAFIV
  ..|.|.|. |....   | .. .||.  ||   |.. | .|..||||||| ..         |  |. |.  .   ..|.|.. |||||.|||| .|.
kledgkikvlalseekeegyiltrlrleekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDA
.| ... |  .. ||.   ...|| .|  .||. ||| |.. ||.  
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1717-1948 4.8e-19 63.1 In-house 46-276 (303) alignment 
Range on Protein: 1717-1948
Range on HMM: 46-276/303.0
MNKHKNRYANVAAYDHSRVVLSNVegypgmDYINANYVDgYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG-TATY
 | .|||...|   |||.| ||.        || |.|..  |  .  | || ||. | .|||.|. |..   ...|    |  ..  |  .|       .
knmdknrfvdvicldhskvklsds......syihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHL-QYTAWPDHGVPDHPTPF-LIFLKRVKTL--NPNDAGPIISHCSAGIGRTGAFIVIDCMLERL
 .  . . |  ..      ....  | . . . . |. .| |||   .| . .|  .  . .....  .  |. | .    .| ||.|.| ...     |
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

R-YDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
   ....|.  |.  .|  | . ||   |. ...  . 
hseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1717-1826 1.7e-13 44.8 In-house 95-199 (244) alignment 
Range on Protein: 1717-1826
Range on HMM: 95-199/244.0
MNKHKNRYANVAAYDHSRVVLSNveGYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERsrvkcDQYWPSRGTATY-
 | .||| .    .| .|| ||.  |  |  |||| .|    .   || || || .|  |||.|. |     .|.|  .||      |.|||      . 
nnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdseplewy

-GDIEVTLLESV
  || ||| .  
eeditvtltdrd
Y_phosphatase Protein-tyrosine phosphatase 1718-1948 9e-88 289.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 1718-1948
Range on HMM: 1-234/235.0
NKHKNRYANVAAYDHSRVVLsnvEGYPG-MDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP--SRGTAT
||.|||| .. .||..|| |   .|..|  ||||||||.||......|||||||..|..|||||||.|.. .|||||.|||..|.||.||||  .... |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIEVTLL-ESV-HLAHYTMRTMRLKMVGEP-EVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERL
||||.|.|  ..  . ..||.|...||  .|. | ||.|.|.||.|||||||..|...| ....|.. . .. ||.. |||||.|||| |...|..||.|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
. ...||.. .|  ||.||  |||..|||||...|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1718-1948 9e-88 289.0 In-house 1-234 (235) alignment 
Range on Protein: 1718-1948
Range on HMM: 1-234/235.0
NKHKNRYANVAAYDHSRVVLsnvEGYPG-MDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWP--SRGTAT
||.|||| .. .||..|| |   .|..|  ||||||||.||......|||||||..|..|||||||.|.. .|||||.|||..|.||.||||  .... |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIEVTLL-ESV-HLAHYTMRTMRLKMVGEP-EVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERL
||||.|.|  ..  . ..||.|...||  .|. | ||.|.|.||.|||||||..|...| ....|.. . .. ||.. |||||.|||| |...|..||.|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
. ...||.. .|  ||.||  |||..|||||...|.|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1718-1948 7.9e-70 229.8 In-house 3-236 (237) alignment 
Range on Protein: 1718-1948
Range on HMM: 3-236/237.0
NKHKNRYANVAAYDHSRVVLSNVEGYpgMDYINANYVDGYD-KPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG-TATY
|| ||||.|. |||||||||    .    |||||.|..|.|  |..|||.||||  .  |||.|||.|.   ||||| | |. ..|| .||||    |.|
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDIEVTLLESVHLAHYTMRTMRLKMV-GEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPN--DAGPIISHCSAGIGRTGAFIVIDCMLERLR
| . |.|    ... ||.|.. | .     ||| |.  |.|.|||.|||.. . .| | |..   .|   ..|| | |||||.|||| |.|||.|| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
  . ||||  | ..  .| |..||..||.|||...|
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0041856 (Phosphotyrosine protein) phosphatases II 1718-1954 2.3e-51 169.3 In-house 1-174 (182) alignment 
Range on Protein: 1718-1954
Range on HMM: 1-174/182.0
NKHKNRYANVAAYDHSRvvlsnvegypGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTnleersrvkCDQYWPsrgtatygd
|..|||| ..  |||||          ..||||||...|. ... .|||||||..|. ||.||..|..  |||.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

ievtllesvhlahytmrtmrlkmvgEPEVREIKHLQYTAWPDHGVPDhPTPFLIFLKRVKTlnpnDAGPIISHCSAGIGRTGAFIVIDCMLERlrydnTV
                         | . |.. ...|. |||||||| .  .| |...|.     . ||.. |||||.||||...... |...      |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

DIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSG
... .|  .| .|. ||.|..||.|...|.|. .  .
sleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_CG42327_pd Subfamily CG42327 1718-1877 8e-37 121.6 In-house 28-191 (319) alignment 
Range on Protein: 1718-1877
Range on HMM: 28-191/319.0
NKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDK-PRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR----GT
 | |.|..||    ..|||| ..   .   |..|.|| |||. | ||||.| .| .. |||||.||| || .|| ||.| |    .| .|.|..    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVREIKHLQYtAWPDHGVPDHPTPFLIFLKRVK
 .|||| ||| .     .| . |. || | . | ||. |  |  |.. .|| ......  | .|.
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1718-1949 7.9e-35 115.3 In-house 43-269 (288) alignment 
Range on Protein: 1718-1949
Range on HMM: 43-269/288.0
NKHKNRYANVAAYDHSRVVLSnvegYPGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR-GTAT-Y
|  ..|| |.   | .|| ||         ||.|| |     .|  | .| ||  |   .|.|. |..   ||||..| |. . | ..|.||. | .. .
nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GD-IEVTLLESVHLAH-YTMRTMRLKMVGEPEVrEIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLnpndAGPIISHCSAGIGRTGAFIVIDCMLERLRY
|    |.  . . . .  .. ..| . .|| .|  .|.| .  |.|.|||.   ..| .|...|.|      ||. |.|||.||||..|.|  .|| || 
grlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlksl....qkPivvhssaGvGrtgtlililialeslrl

DNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLD
|. . |   .. ||..|   .||| ||...|  ||.
ddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_eak_pd Subfamily eak 1718-1877 2e-15 51.0 In-house 52-208 (332) alignment 
Range on Protein: 1718-1877
Range on HMM: 52-208/332.0
NKHKNrYANVAAYDHSRVVLSNVEGYPgMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRG--TATY
. ..|   ..  ||.  | |..    .   ||||  ..  .  | || |  .  .    ||.|| |..| .||.| .  |    | |.|.| ..     .
avnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

GDIEVTLLESVHLAHYTMRTMRLKMvGEpEVREIKHLQYTAWPDHGVPDHpTPFLIFLKRVK
| ..|.  | |. . . .| . |.. |. |  ...| ..  | .  .|     || . | .|
Gildverkefvkrniletrllelsk.Gn.ethrvlhykvfGwtettlpky.edflalrkvmk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1718-1806 6.4e-12 39.6 In-house 34-121 (332) alignment 
Range on Protein: 1718-1806
Range on HMM: 34-121/332.0
NKHKNRYANVAAYDHSRVVLSNVEGYpgMDYINANYVDGYDKPRSYIATQGPLPE-TFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQY
|   ||   . ..||||| |.  .|    |. ||..|||| |  .|| .| |. . |   ||||| | .   |... ...|. . |.   
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1719-1953 5.7e-33 108.9 In-house 44-278 (312) alignment 
Range on Protein: 1719-1953
Range on HMM: 44-278/312.0
KHKNRYANVAAYDHSRVVLSNVEGYpgmdYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR-GTATYGD
|  ||| |.  .|  |  |.  | .    || ||.|    ||  ...||||| .| . ||...    |..|..|. . | .  || .|     |     |
kdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

IEV-----TLLESVHLA--HYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKtlnpNDAGPIISHCSAGIGRTGAFIVIDCMLER
  |     | .|    .  . | | ... .    .   ..| |...|||||.||     | .|  ||    .|  |.|.|||||.||||....|. |.  
hrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmiaa

LRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNS
||.    ..      || .|.  |..  ||..   .||. . |
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1719-1822 9.3e-24 78.8 In-house 48-162 (350) alignment 
Range on Protein: 1719-1822
Range on HMM: 48-162/350.0
KHKNRYANVAAYDHSRVVLS--------NVEGYPGMDYINANYVDGY----D-KPRS-YIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCD
  |||| |.  |.|||| |             . . |||||||.       . .|   |||||.|||.|. ||.... . .   |..||.. |  . ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPSRGtatYGDIEVTL
.||.  .   | || | |
rYWqegs...ydditvkl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1721-1948 4.1e-20 67.1 In-house 22-256 (290) alignment 
Range on Protein: 1721-1948
Range on HMM: 22-256/290.0
KNRyANVAAYDHSRVVLSNVEGYPGMDYINANYVDgYDKPRSYIATQGPLPET-------FSDFWRMVWEEQSVTIVMLTNLEERSRV----KCDQYWPS
..| ..|.   ..|||| .       ||| ||.|  . .    |.|| |. ..         .|| |. .|..  .||| . ||.|.      | .| | 
dqR.levpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

RG--TATYGDIEVTLLESVHLAHYTMRTMRLKMVGEPEVrEIKHLQYTAWPDHGVPDHPTPFLiflKRVKTLNpNDAGPIISHCSAGIGRTGAFIVIDCM
.     ......|   . ..     .|.. .|  .| |   ..| ..  | .  |....  .|   . ..... .   |.| ||  || |  |.  |.  
svgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktll...sliqkvk.asktpvivHcvdGiSrsAalaaiilg

LERLR-YDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVL
   .    . | .   . ||| ||  ........ |.  ...
yQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
0044763 (Phosphotyrosine protein) phosphatases II 1730-1946 4.5e-37 122.8 In-house 2-166 (178) alignment 
Range on Protein: 1730-1946
Range on HMM: 2-166/178.0
YDHSRVVLSNVEGYPGMDYINANYVDGYdkprSYIATQGPlpetfSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTatygdievtllesvhla
.|..||.|||.||... |||||......     |.....|     .|......|.   .||.||.  |. ..|||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

hytmrtmrlkmvgepevreiKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERlrydnTVDIYGCVTALRAQ
                     . ... .||||||| .  || |.. .... ... ||.. |||||.||.|...... |...      .... ..  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrer

RSyMVQTEEQYIFIHDA
|. .|....|. .... 
Rp.ivpnpgqlrqLyef
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1736-1823 1e-09 32.8 In-house 11-85 (130) alignment 
Range on Protein: 1736-1823
Range on HMM: 11-85/130.0
VlsnvegypGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERsrvkcDQYWPSRGTATYGDIEVTLL
         | .||||..|   .. . |. || || .|  |||.|. |     .|.|  .||      |.|||      . . .... 
q........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivt
0046846 (Phosphotyrosine protein) phosphatases II 1743-1947 5e-44 145.4 In-house 9-169 (176) alignment 
Range on Protein: 1743-1947
Range on HMM: 9-169/176.0
YPGMDYINANYVDGYDkprsYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYgdievtllesvhlahytmrtmrlkmvg
 ...||||||...|.     .||||||||.|. ||..|..|..  ..|.||.. | .|.||..|||   .. .                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

epevreikHLQYTAWPDHGVPDHpTPFLIFLKRVKTLNPNDaGPIISHCSAGIGRTGAFIVIDcmleRLRYDNTVDIYGCVTALRAQRS-YMVQTEEQYI
        . ... ||||||||. . .| .|. ...   .. ||.. ||||||||||......     |.... .... ..  .|.||. ..|||.||| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

FIHDAV
|.....
flyefe
0043147 (Phosphotyrosine protein) phosphatases II 1744-1944 4.5e-45 148.8 In-house 3-154 (172) alignment 
Range on Protein: 1744-1944
Range on HMM: 3-154/172.0
PGMDYINANYVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLeersrvkcdqywpsrgtatygdievtllesvhlahytmrtmrlKMVGE
.| |||||.|.|.| .|...|||||||..|..|||||..|..  .||.||.|                                              .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

PEVREIKHLQYTAWPDHGVPdHPTPFLIFLKRVKT-LNPNDAGPIISHCSAGIGRTGAFIVIDCMLerlrydNTVDIYGCVTALRAQRSYMVQTEEQYIF
...|.. ...|. ||||||| ..  .| ||. ... |. .. ||.. |||||.||||...... ||        .... .|  .|..|...||...||.|
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

IH
..
ly
0051082 (Phosphotyrosine protein) phosphatases II 1746-1947 3.3e-37 122.7 In-house 3-149 (151) alignment 
Range on Protein: 1746-1947
Range on HMM: 3-149/151.0
MDYINANYVDGYdkprsYIATQGPLPetfsDFWRMVWEEQSVTIVMLTNLEERSrvKCDQYWPSRGtatygdievtllesvhlahytmrtmrlkmvgepe
 ||||..||.|.     .....|||.    ||.....|..  |||.|...|||   .| .|.|. |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

vREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTlnpNDAGPIISHCSAGIGRTGAFIVIDCMLERlrydntVDIYGCVTALRAQRSYMVQTEEQYIFIHD
 .|..|.... |||.|.|...  .| ||. .     .. ||.. |||||.||||.......||..      |... ..  .|..| ..||...|..|.. 
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AV
|.
al
0051429 (Phosphotyrosine protein) phosphatases II 1747-1968 8.7e-57 188.1 In-house 5-241 (272) alignment 
Range on Protein: 1747-1968
Range on HMM: 5-241/272.0
DYINANYVDGYDK---PRSYIATQGPLPETFSDFWRMvWEEQSVTIVMLTNLEERSRVKCDQYWP------------SRGTATYGDIEVTLLESVHLAHY
.||||..|.|| .   |. .....|||| |  ||||. .|..  |||.|...||| |.|||.|||            |  | .||.. ||||. ..| .|
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

TMRTMRLKMV-GEPEVREIKHLQYTAWPDHGVPDHPtpFLIFLKRVKTlnpndAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVD--------IYGC
..|...|... .  |.||. ||.||.|||||||...  .| .|. . .      ||.. |||||..||| ..... .|... ..  ||        ....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

VTALRAQRSYMVQTEEQYIFIHDAVLDAvNSGSTEVPASRLHQHLH
|  ||||| ..|||||||.|...|.|..   . ..|.|. |...|.
veelraqrpgavqteeqylflyeallel.lrsllsvraeyllaald
0036282 (Phosphotyrosine protein) phosphatases II 1747-1945 1.5e-48 160.1 In-house 3-164 (174) alignment 
Range on Protein: 1747-1945
Range on HMM: 3-164/174.0
DYINANYVDGYDKPRSYIATQGPLPetfsdFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSrgtatygdievtllesvhlahytmrtmrlkmVGEPEV
|||||...|..  .. .||.||||.     ||.|..|... |.|||....|. ..|| .|||.                                 | ..
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredle

REIKHLQYTAWPDHGVPDHPTpFLIFLKRVKTLNPN-DAGPIISHCSAGIGRTGAFIVIDCMLERLRyDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHD
|.. ...|. |||||||| .. .| |.|.|..   . . ||.. |||||.||||...... || .|.  ..||..  | .|| ||..||||..||.|...
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 1753-1945 1e-43 144.0 In-house 1-144 (152) alignment 
Range on Protein: 1753-1945
Range on HMM: 1-144/152.0
YVDGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWpsrgtatygdievtllesvhlahytmrtmrlkmvgepevreikHL
..||| .|. .||||||.|.|..|||||..| .  ||||||.|.|. ..||.||.                                           . 
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLerlrydNTVDIYGCVTALRAQRSYMVQTEEQYIFIHD
... ||||||||..  .|..|. .. |. .. ||.. |||||.||||...... ||      . |... .|  .|..|...|....|..|...
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1755-1851 6.9e-13 42.7 In-house 230-322 (440) alignment 
Range on Protein: 1755-1851
Range on HMM: 230-322/440.0
DGYDKPRSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSrvkCDQYWPSRG-TATYGDIEVTLLESVHLAHYTMRTMRLKMVGepEVREIKH
.|| |  ..|||| ||  |  ||||.| . .  ||.|| .|....   |  |||    . |.| . |    |  .    .||. ||     || ||. 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyke..evheirq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1761-1944 3e-25 83.6 In-house 5-197 (199) alignment 
Range on Protein: 1761-1944
Range on HMM: 5-197/199.0
RSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPS--RGTATYGDIEVTLLESVHLAHYTMRTMRLK--MVGEPEVREIKHLQYTA
| ||||| || ||..|||.||||  |  |||. . .    .    |||.   ||. || . ||    .  . ||. .. |       |  ||| | |.|.
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDHP--TPFLIFLKRV-KTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYD--NTVDIYGCVTALRAQRSYMVQTEEQYIFIH
| ..  |.      |..  . | |  . .   |.| ||| | | || |. .|  .          ||..     ||  |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1761-1944 3.4e-25 83.4 In-house 4-196 (198) alignment 
Range on Protein: 1761-1944
Range on HMM: 4-196/198.0
RSYIATQGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPS--RGTATYGDIEVTLLESVHLAHYTMRTMRLK--MVGEPEVREIKHLQYTA
| ||||| || ||..|||.||||  |  |||. . .    .    |||.   ||. || . ||    .  . ||. .. |       |  ||| | |.|.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDHP--TPFLIFLKRV-KTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYD--NTVDIYGCVTALRAQRSYMVQTEEQYIFIH
| ..  |.      |..  . | |  . .   |.| ||| | | || |. .|  .          ||..     ||  |  .. . ..| ||.
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1767-1945 3.8e-17 56.7 In-house 97-282 (302) alignment 
Range on Protein: 1767-1945
Range on HMM: 97-282/302.0
QGPLPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR--GTATYGDIEV-------TLLESVHLAHYTMRTMRLKM--VGEPEVREIKHLQYT
  |  .|   .| .. . .   .| |... |    || .|.  .  |. ..|   |        | |     .... |. .|   . .   . .. |...
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPDHPTPFLIFLKRVKTLNPNdagpIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHD
|||||| |... . |  ||  ..   |    .. |||||.||||... |   ..    ... |.   |. .|. |   ||.|.| |..  
awpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_hpo-7_pd Subfamily hpo-7 1770-1955 3.8e-19 63.6 In-house 43-231 (263) alignment 
Range on Protein: 1770-1955
Range on HMM: 43-231/263.0
LPETFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR--GTATYGDIEVTLLESVHlaHYTMRTMRLKM-VG-EPEVREIKHLQYTAWPDHGVPDH
| .|   |....   .. ..|||.. .| ...||..|.|    .   . ...|.  ....     ..|  |   .|   .....|| .|. |...  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

PTPFLIFLKRVKTLnpndaGPIISHCSAGIGRTGAFIVIDCM----LERLRYDNTVDI--YGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGS
.   |  || .. .      ... |||.||||. || |.. .    .  |.  .||..     .. || .|.  ..|  |  |    ||| |    
areilnilkvarns.....kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1773-1963 1.9e-22 74.6 In-house 40-227 (255) alignment 
Range on Protein: 1773-1963
Range on HMM: 40-227/255.0
TFSDFWRMVWEEQSVTIVMLTNLEERSRVKCDQYWPSR--GTATYGDIEVTLLEsvHLAHYTMRTMRLK-MVG-EPEVREIKHLQYTAWPDHGVPDHPTP
|   |....   .. ..|||....| ...||..|.|    .   . |..||  .    |.  .||...  ..|   . ...|| .|. |...  |. .  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FLIFLKRVKtlnpnDAGPIISHCSAGIGRTGAFIVIDCML----ERLRYDNTVDI--YGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVnsgsteVPASR
 |  || |.     |. ... |||.||||. ||.... .       |.  .||..     .. || .|.  ..|  |  |    ||| |       |.. 
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv......fpkge

L
|
l
0048076 (Phosphotyrosine protein) phosphatases II 1806-1947 1.8e-26 88.0 In-house 2-139 (145) alignment 
Range on Protein: 1806-1947
Range on HMM: 2-139/145.0
YWPSR--GTATYGDIEvTLLESVHLAHYTMRT-MRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDaGPIISHCSAGIGRTGAFI
||||.  .   .|..  | |.  .|...  .|  .| .  | ..|.. ...|. |||||||| .  .| ||. .... ... ||.. |||||.||||...
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

VIDCMLErlrydNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAV
....||.     . |... ..  .|.||...|....|..|.....
aaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 1824-1945 6.1e-25 83.0 In-house 24-139 (144) alignment 
Range on Protein: 1824-1945
Range on HMM: 24-139/144.0
ESVHLAHYTMRTMRLKMVGEPEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPNDaGPIISHCSAGIGRTGAFIVIDCMLerlryDNTVDIYGCV
.  .| ..|  ... .   | . ||. ..... ||||||||... .| ||. .... ... ||.. |||||.||||...... |.      . .... ..
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleeal

TALRAQRSYMVQTEEQYIFIHD
  .|..|...|....|..|...
alvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1842-1948 4.1e-15 50.3 In-house 212-341 (350) alignment 
Range on Protein: 1842-1948
Range on HMM: 212-341/350.0
GEPEVreIKHLQYTAWPDHGVPDHPTPFLIFLK----RV------KTLNPNDAGPIISHCSAGIGRTGAFIVIDCMLE-------------RLRYD-NTV
 .| |  . .||.  |.| ..  .|  .|  |.     .      . |. . . ||. |||||.|||| .. .| .|.             .| .  .| 
sdPyv..vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktr

D-IYGCVTALRAQRSYMVQTEEQYIFIHDAVL
| |   |  || ||  |||. .|.|||..|.|
DlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1845-1968 1.7e-23 77.7 In-house 87-211 (440) alignment 
Range on Protein: 1845-1968
Range on HMM: 87-211/440.0
EVREIKHLQYTAWPDHGVPDHPTPFLIFLKRVKTL-NPNDAGPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFI
| | .|. .| .|||.|||    | | ... |.   .    ||.. ||||| ||||  |..|..|   .  . .||.  . ..| .|  |||| ||| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAVLDAVNSGSTEVPASRLHQHLH
|.|||... .| | .    . ....
heavlegllcgdtliledditerve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1848-1949 2.8e-09 30.8 In-house 219-342 (349) alignment 
Range on Protein: 1848-1949
Range on HMM: 219-342/349.0
EIKHLQYTAWPDHGVPDHPTPFLIFLKrVK-----------TLNPNDAGPIISHCSAGIGRTGAFIVIDCMLE----------RLRYDNTV-D-IYGCVT
|.  ||.  |.| ..   |  .|  |. ||            |. ..  ... ||||| |||| .. .| .|.          .. . .   | |.  | 
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

ALRAQRSYMVQTEEQYIFIHDAVLD
 || ||  |||   |.|.|..|.| 
elrkqrismvqnlaqfiaiyealLk
PTPc_DSPc_SM00012 1849-1948 2e-34 113.3 In-house 2-104 (105) alignment 
Range on Protein: 1849-1948
Range on HMM: 2-104/105.0
IKHLQYTAWPDHGVPDHPTPFLIFLKRVKTLNPND--AGPIISHCSAGIGRTGAFIVIDCMLERLRYD-NTVDIYGCVTALRAQRSYMVQTEEQYIFIHD
.||..||.|||||||......| .|. ||. . .   ..|.. |||||.|||| |...|..|..|..  ..|||. .| .|| ||. ||||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVL
|.|
all
subfamily_PTPDC1_pd Subfamily PTPDC1 1855-1945 7.8e-07 23.7 In-house 88-170 (182) alignment 
Range on Protein: 1855-1945
Range on HMM: 88-170/182.0
TAWPDHGVPDHpTPFLIFLKRVKTLnpNDAGPIISHCSAGIGRTGafIVIDCMLerlRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHD
 .|.|.||.   .  |   | |.     . | .  || || ||||  ..| |.|    | . ..    .. .|..|.  .|| ||  ....
fgwkDygvasl.eriLdivkvvafa..lqegkvavhChaGlGrtG..vliacyl...vyakrltaekaiklvrskrpksiqtreqvelvke
subfamily_eak_pd Subfamily eak 1872-1952 1e-07 25.7 In-house 226-306 (332) alignment 
Range on Protein: 1872-1952
Range on HMM: 226-306/332.0
FLKRVKTLNPNDAgPIIsHCSAGIGRTGAFIVIDCMLERL--RYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVN
.||. .   |  | |||  .. |  |.|.|.||| ... .  .  |.  .   .   . .| . | .. |. ||...||| . 
tlkkyihtppsfa.pii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1878-1951 3.2e-14 47.5 In-house 223-295 (297) alignment 
Range on Protein: 1878-1951
Range on HMM: 223-295/297.0
TLNPNDAgPIISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAV
.  | .| ... |||||.||.|  .  | .|..|| .   |.   .. || ||. .||| ||. ...||||  .
aemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 1883-1945 1.1e-13 45.5 In-house 246-309 (319) alignment 
Range on Protein: 1883-1945
Range on HMM: 246-309/319.0
DAGPIISHCSAGIGRTGAFIVIDCMLERLRYD-NTVDIYGCVTALRAQRSYMVQTEEQYIFIHD
. ||.. ||| |.||||  |  |  ...|    ..|||   |  .| .|.  |.| ||| ||. 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiyk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1888-1954 1e-16 55.0 In-house 2-68 (69) alignment 
Range on Protein: 1888-1954
Range on HMM: 2-68/69.0
ISHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSG
. |||.| ||||.|| |   . |.. .  |||.  |  .|  |  ||  | .|||||||. .|.  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklG
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1889-1954 3.4e-16 53.4 In-house 2-67 (69) alignment 
Range on Protein: 1889-1954
Range on HMM: 2-67/69.0
SHCSAGIGRTGAFIVIDCMLERLRYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSG
 |||.| ||||.|| |   . |.. .  |||.  |  .|  |  ||  |..|.|||||. .|.  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
0051299 (Phosphotyrosine protein) phosphatases II 1954-2241 4.4e-90 297.3 In-house 1-286 (288) alignment 
Range on Protein: 1954-2241
Range on HMM: 1-286/288.0
GSTEVPASRLHQHLHILSqpsADQLSGIDMEFRHLTTLKWTsNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIA
|.||.... |..... |    |..|.|. .||..|. |... . ...|.|| |..|||  . .|||..||... |.| .||||||||.||||.   ..||
gdteisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

TQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDI----NTREVRTVRQFHFMEWPDVG
||.|...| .|||| .||.|...| || .. |.|.|.|  ||||.. ...| ..|. . |. ...| .|.......     . |.|||..||.. ||| |
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

KPHTADHFLDFVTQVHNTYAqfGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 |......|||. .|.. .|   . ||. |||  | |||..|||| ..|.....|..|||. .|| ||. | .|.| |||| |.| |..|||
vpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 1958-2240 2.9e-74 244.8 In-house 7-284 (293) alignment 
Range on Protein: 1958-2240
Range on HMM: 7-284/293.0
VPASRLHQHLHILSqpsADQLSGIDMEFRHLTTLKwTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAP
. ......|.. ..   ||.  ..  |. .| ... ... ...|.|.||| |||.   .||| .|| .  | . .|||||||..|.||. .  .|||| |
iklekfeehvkkmk...adsdlrfseeyeelkavg.kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP

TNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLE-TGVQVGMLVVEPMAEYDMKHYHLREFRISDinTREVRTVRQFHFMEWPDVGKPHTADH
  ||  |||| .||..| || || .. |.|...| .||| . . |. | . |. .|| ..... .||..|.   ..| |.|||.||. ||| | |.... 
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektkt

FLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEY
.|||| .|...  .   ..||.||| .| ||| .||||  .|.... | .||.|..|  ||.||....|  .|| |.. .  ..
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_PTPN6_pd Subfamily PTPN6 1962-2242 1.1e-67 223.2 In-house 8-298 (306) alignment 
Range on Protein: 1962-2242
Range on HMM: 8-298/306.0
RLHQHLHILSQpS--ADQLSGIDMEFRHLTTLKW-TSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRlLPGADGSDYINASWIDGY--KERGAYIATQA
...|. . |.. .    . .|.  || .| . .  .    . .. | |. |||. . .|.| .|||..  |.  |||||||. |..   ... .||||| 
eieqrvselek.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqg

PTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLET-GVQVGMLVVEPMAEYDMKHYHLREFRISD-INTREVRTVRQFHFMEWPDVGKPHTA
  ..| .|||| .|. || .| |. . .|||.|.|. ||| |.   . | . |. ..| ....| |||...|   . .| |.|.|.|| .||| | |.  
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdp

DHFLDFVTQVHNTYAQFG--CTGPITVHCCSGAGRTAVFIALSIILDRMRAE---HVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
...|||...|.. . ..    .||| ||| .| |||  || . |.|. .. .     .|. ..||..|. |. ..|  .||.|.| |  .|. 
gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1963-2245 1.5e-82 272.2 In-house 10-287 (319) alignment 
Range on Protein: 1963-2245
Range on HMM: 10-287/319.0
LHQHLHILSQpsaDQLSGIDMEFRHLTTLKWTsnRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETA
|...|..| .       ... ||..| . . .    . |. . |..|||    ..||  ||..  |.| .||||||||.||||.|| ..|||||| ..| 
Lkerlkalas...tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlenti

ADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRIsDINTREV--RTVRQFHFMEWPDVGKPHTADHFLDF
 |||| .||..| |. || . .|... ... ||| |. .. | |.|..  |  ...|  |.. . .... ||  |.| .|...|||| . |..|   ||.
edfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldl

VTQVHNTYAQFGcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
. .....  .    |||.|||  |.|||  ||.|...|.|.. | |.|||.||. ||| |. |.|.||||.|.| |  |.. |.|
lkrirksrektq.sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0043336 (Phosphotyrosine protein) phosphatases II 1965-2241 5.3e-82 270.7 In-house 6-277 (278) alignment 
Range on Protein: 1965-2241
Range on HMM: 6-277/278.0
QHLHILSQPSADQLSGIDMEFRHLTTLKWtsNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAAD
. |. | .. ..  ...  || .|.. |.  . ...|.|| |..|||. . .|||..||.. ||.|  .|||||||..|||.   ..||||.|..|| .|
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPlETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQV
||| .||.....| ||..  |.|...|  ||| .. ...| ..|. . |. ...|..| .....  . |.|||...|.. ||| | |.. ...|||. .|
FwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

HNTYAqfGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
.. ..   . ||. |||  | |||..|||| ..|.... |. ||.. .|| ||. | ...| |.||.||| |..|||
reale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1966-2055 5.9e-12 39.6 In-house 11-94 (95) alignment 
Range on Protein: 1966-2055
Range on HMM: 11-94/95.0
HLHILSQPSA-DQlsGIDMEFRHLTTLkwTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRllpGADGSDYINASWIDGYKERGAYIATQ
| |.|   |  ||   .| ||. ..    .    ||     | ||||.|  .|||. ||..        |||||| ..|||  . .|||.|
hshvlemhsnsdq..efdnefksismt..sgapytvgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq
0050432 (Phosphotyrosine protein) phosphatases II 1968-2243 8.5e-89 293.2 In-house 33-301 (308) alignment 
Range on Protein: 1968-2243
Range on HMM: 33-301/308.0
HILSQpsADQLSGIDMEFRHLTTLKWtSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMrllpgADGSDYINASWIDGY--KERGAYIATQAPTNETAADF
..| .  |..|.....||..|. .|  .. ..||.|| |..|||  . .|||..||..      .||||||||..|||  | . ..||||.|...| .||
kllek..aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedF

WRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLE---TGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVT
|| .||.|...| || .. |.|.|.|  |||||   . ...|...|. . |. ...| .|......... |.|||..||.. ||| | |. ....|||. 
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

QVHNTYaqfgCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAA
.|....      ||| |||  | |||..|||| ..|.....|. |||| .|| ||. | .|.| ||||.||| |..|||  
lvrksl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1968-2244 2e-70 232.4 In-house 12-286 (305) alignment 
Range on Protein: 1968-2244
Range on HMM: 12-286/305.0
HILSQpSADQLSGIDMEFRHLTTLkwtSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWR
.| .. .... .|.......|...   .. . | .  .|. |||. . ...| .|.|..  .  | |||||||..||||.. .||..|.| ..| |||||
yikea.rvysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWr

AIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGV--QVGMLVVEPMAEYDMKHYHLREFRISD-INTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQV
 |.|     | ||... | |...|  ||| ...   . | ..||   |  .. |  |...||   . .| ||| |... .||| | |..|  .|... .|
liveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

HNTYAQfGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAY
.... . .   |..|||  | ||| ||||..| |.|...| |||||  .| ||..| .|.|. .|| ||. |  |.. . 
qkdqkk.dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
0039614 (Phosphotyrosine protein) phosphatases II 1970-2244 2.9e-83 275.0 In-house 23-292 (297) alignment 
Range on Protein: 1970-2244
Range on HMM: 23-292/297.0
LSQPSADQLSGIDMEFRHLTTLKWtsNrCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGA-DGSDYINASWIDGYKE-RGAYIATQAPTNETAADFWR
|    |.. .....|| .|  ||   . ...|.||.|..|||  . .|||..||.   ..|   .|||||||..|||.    ..||||.|..|| .||||
lllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

AIWEHNSPIIAMLVRTNERGQeQCSDYWPLETGvQVGMLVVEPMAEYDMKHYHLREFRISDinTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNT
 .||.....| || ...|.|. .| .||| |.| . | ..|. . ..  ..|..|......  . |.|||..|... ||| | |......|.|. .|.. 
mvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrea

YAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAY
.|. .  ||. |||  | |||..|||. ..|.... |. |||. .|| ||  | ...| |.||.||| |..|.|  .
laelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 1970-2241 2.4e-80 265.8 In-house 18-304 (307) alignment 
Range on Protein: 1970-2241
Range on HMM: 18-304/307.0
LSQPSADQLSGIDMEFRHLTTLKWT-SNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGA-DGSDYINASWI--------DGYKERGAYIATQAPTN
. .  .| |.|.  ||..|  .. . .. ...|.||.|..|||  . .|||..||..  |.|  ..|||||||..        |||.   ..||||.|..
vllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlp

ETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGV-QVGMLVVEPMAEYDMKHYHLREFRISDI-NTREVRTVRQFHFMEWPDVGKPHTADHF
|| .|||| .||... .| || .. |.|.|.|  |||.| .. . | ..|. . |. ...|..| ....|   | |.|||..||. .||| | | . ...
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHV---VDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
|||. .|.. ... .. ||. |||  | |||..|||. ..|.....|..   ||.. .|||||  | ...| ||||.||| |..|.|
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1970-2243 1.9e-62 205.9 In-house 6-278 (281) alignment 
Range on Protein: 1970-2243
Range on HMM: 6-278/281.0
LSQPSADQLSGIDMEFRHLTTLKwTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAI
| | |... .|  .|...|. .  ..|  | .. . |. |||    | ||  || .     .  .|||||....|||.  .|||||.|  .. ..||. .
lkqlsqndnaGfieeyeklaaig.vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEHNSPIIAMLVRTNERGQEQCSDYWPLET-GVQVGMLVVEPMAEYDMKHYHLREFRIsDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTY
||..  .|.|. |  | |. .|  ||| ..  ...| ..|. .|| . ..|  |.|.. . .. | |.|.|.... ||| | |.|. ..|.| ..|... 
weqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklt

AQFGCtGPITVHCCSGAGRTAVFIALSIILDRMRAE-HVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAA
 .     |. .|| .| ||| ..|||  ..... || . .||  .|. || ||. |.|   ||.|.|.|  ..|  
ekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN23_pd Subfamily PTPN23 1970-2241 7.6e-55 180.7 In-house 6-280 (288) alignment 
Range on Protein: 1970-2241
Range on HMM: 6-280/288.0
LSQPSADQLSGIDMEFRHLTTLKWTSNR-CTVANLPVNRPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWIDGYKER-GAYIATQAPTNETAADFWR
| .   |. ...| .|. |.. .   .|  ..|   ..  |||    .|||.||| .|        ||||||.. .       .|||||| ..|..|||.
lqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl

AIWEHNSPIIAMLVRTNERGQEQCSDYWPLETG--VQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVH
 ..|  |..| ||.  .|.|..... ||| ..|  |. | | |    . .....  |.....  ....|..|.  ....||..| |.. ...|.|. .|.
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

N--TYAQFGCTGPITVHCCSGAGRTAVFIAL-SIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
.  .  |  .  |. ||| .| ||| ||  . ... .  . . ..|.   |. ||..|..|.|| ||..|.| |  |. 
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1971-2235 8.4e-70 230.1 In-house 13-273 (288) alignment 
Range on Protein: 1971-2235
Range on HMM: 13-273/288.0
SQPSADQLSGIDMEFRHLTTLKWTSNRcTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIW
 . ||.. .|.  |.. |..|. |..  |...|.|| .|||    .||| .|| .. |.  .|.||||||.|||.|.. .|||||.|  .|  |||. ..
akksarnrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvy

EHNSPIIAMLVRTNERGQEQCSDYWPLETG-VQVGMLVVEPMAEYDMKHYHLREFRISdiNTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYA
|...  |.||    |.|...| .||| .   .. | . |. . . ..... ||.. .    . . ... |.... ||| | |. .  .|....||...  
enktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

QFgcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYL
.   ||||.|||  | ||| .||||  ..|....| ..||. ||. || .|....|. .|| |.| 
ad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiye
0047943 (Phosphotyrosine protein) phosphatases II 1972-2241 4.1e-85 280.8 In-house 5-272 (273) alignment 
Range on Protein: 1972-2241
Range on HMM: 5-272/273.0
QPSADQLSGIDMEFRHLTTLKWtSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMrllpGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWE
  ....|... .||..|. ||. .  ..||.|| |. |||  . .|||..||..    | .||||||||..|||.   ..||||.|...| .|||| .||
lekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

HNSPIIAMLVRTNERGQEQCSDYWPLET---GVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTY
.|...| ||... |.|.|.|  |||||     ...| . |. . |.  ..| .|........| |.|||..||...||| | |.. ...|.|. .|....
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkal

AQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
...   ||. |||  | |||..|||| ..||....|. |||. .|||||. | .|.| |||| ||| |..|||
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 1973-2245 1.4e-83 275.9 In-house 7-281 (297) alignment 
Range on Protein: 1973-2245
Range on HMM: 7-281/297.0
PSADQLSGIDMEFRHLTTLKWtSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMrllpGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEH
.....|...  ||..|. |.. .  ..||.|| |..|||  . .|||..||..    . .||||||||..|||.   ..||||.|...| .|||| .||.
ekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

NSPIIAMLVRTNERGQEQCSDYWPLE--TGVQVGMLVVEPMAEYD--MKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTY
|...| ||..  |.| |.|  |||||    ...| ..|. . ..    ..|.||.....|... |.|||..||.. ||| | |......|||. .|.. .
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

AQFGCTGPITVHCCSGAGRTAVFIALSIILDRMR---AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
...   ||. |||  | ||...|||. ..|....    |. ||.. .|| ||. | ...| .|||.||| | .|.|  ..
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1974-2245 1.1e-75 249.7 In-house 22-294 (298) alignment 
Range on Protein: 1974-2245
Range on HMM: 22-294/298.0
SADQLSGIDMEFRHLTTLKW--TSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWE
 . .|.| ..||..|.. .    ..  .||. | |. |||  . ...|| ||...   . . |||||||....||.| |.|||||| .|| .|||| ..|
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvte

HNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNtYAQF
...  | ||  ..| .. ... ||| |   . |.. |. ......  .  |.. .|. .... |.|||.||..||| | |..|   ||....|.  . | 
edigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqq

GCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
    |..|.| .| ||.  |||.. .|.|...|.||||| .|| ||..| ...|  ||| |.| |  |.|....
agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
subfamily_PTPRG_pd Subfamily PTPRG 1974-2244 4.1e-75 248.1 In-house 14-290 (563) alignment 
Range on Protein: 1974-2244
Range on HMM: 14-290/563.0
SADQLSGIDMEFRHLTT-LKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGS-DYINASWIDGYKERGAYIATQAPTNETAADFWRAIWE
 ||.  |.. ||  |..  . ..  .. .. | |. ||| |. |.||. || .. ||| ... |||||..||||.   |.|||| | ..|. |||| |||
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWe

HNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTR------EVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVh
.|. || |.   .|||...|  ||| .. ...| | |  ..|  .  |  |.. | ... .      ....|||.|. .|||.| |. .   | || .  
qnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.

nTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAY
  .|.   .|||.||| .|.||| ..|.|. .| ....|..|.|| ..| .|..|....|. ||| ||. |  | .|. 
.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1974-2240 5.5e-73 241.1 In-house 29-291 (319) alignment 
Range on Protein: 1974-2240
Range on HMM: 29-291/319.0
SADQLSGIDMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHN
  |.|. . .|||... |       | |||. |. |||.   ...| |.| .. | | ..|||||||...||. .  |||.| | ..| ||||| |||.|
fdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyn

SPIIAMLVrtnergQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISD-INTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFG
.  | .|       ...||.||||.. .. .   |.  .  . . | .|....|.  . ...| ..||||. |||||.|. .  .. .| .|.    .  
cstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsken

CTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE-Y
   .| ||| .|.||| |.|.| ..||||. |. |||. .|. || .|....|.  ||.|.| |  | .
hranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPRA_pd Subfamily PTPRA 1975-2241 1.3e-79 262.5 In-house 28-295 (330) alignment 
Range on Protein: 1975-2241
Range on HMM: 28-295/330.0
ADQLSGIDMEFRHLTTLKWtSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNS
||.   .  ||  | . .   . . .|.   |. |||..  .||| .|||.  . | . |||||||.||||||.  .||.| | .||  |||| |||..|
addnklfreefnalPagpi.qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqks

PIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRIS----DINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQ
  | ||   .|| .|.|  ||| |  |  | . ||   |  ...| .|.| .       . ...| ||||||  ||||| | ..   |... .|...  |
ativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq

FGCtgPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 .   ||.||| .|.|||  ||.|. .|.|..||..|||| .|| ||. | .|.|  |||.|.| .  || 
sag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN9_pd Subfamily PTPN9 1977-2241 9e-68 223.5 In-house 14-290 (297) alignment 
Range on Protein: 1977-2241
Range on HMM: 14-290/297.0
QLSGIDMEFRHLTTLKWtSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPI
. .|.  |. ..   .  . . ....|..|  |||    . ||. || .  ... . ||||||...||||.. |.|||| | ..|  |||| .||..  .
gkrGlskeyaeirnepv.eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlv

IAMLVRTNERGQEQCSDYWPL--ETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQF---
| |  |. |||. .|. ||||  |.  . | | |. .    ...|. | . |....|.| |.|  | |. ||| | |..|  .||.. .| .. |..   
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke

-------GCTG-PITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
        ..| || ||| .| |||  ||.| | |.|.. . .|||. ||||||| |  .|| ||||.| |||  || 
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1977-2247 2.2e-60 199.0 In-house 18-289 (290) alignment 
Range on Protein: 1977-2247
Range on HMM: 18-289/290.0
QLSGIDMEFRHLTTlKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGA-D-GSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNS
. .|   .|  | .    ..  ||.. . |...||.   |.|| ||...| ..|  |   .||||..|.||||. .|||||.|...|..|||. ||....
gnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

PIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINT-REVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGc
.|| ||.  .| |...|  ||| .   ..|   .. . |  ...|  |.... . |.  . ..| |...  |.. || .     |  .... .|  . | 
tiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.

TGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYDNF
 ..| |||  . ||.|||.|. . ..... | |.|||  .| .|. . ...|  .||....    .||  ....
ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1978-2239 3.7e-34 113.0 In-house 5-257 (267) alignment 
Range on Protein: 1978-2239
Range on HMM: 5-257/267.0
LSGIDMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPII
   |. ||  .. .  ||....      |. .||.  ..||| .|||.|        .|||||...||| . |.|.|| | . | .||.  | ... |.|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

AMLVRTnerGQEQCSDYWPLETG--VQVGMLVVEPMAEYDMKHYHLREFRISDINtREVRTVRQFHFMEWPDVGkphTADHFLDFVTQVHNTYAQFGCTG
 .| ..   ....   .|| . |   .   |.||   | . . |..  . .   |    . |  ... .|           .|  .  .           
vlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnint...nnkpylkplfgilaknqlengnr

PITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
|. |.|  | ||.  |. .   |.|.. | |.|.|  .. .|  |  ...  |.| ...    |
PlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0040438 (Phosphotyrosine protein) phosphatases II 1979-2241 2.2e-83 275.5 In-house 18-276 (317) alignment 
Range on Protein: 1979-2241
Range on HMM: 18-276/317.0
SGIDMEFRHLTTLKWTsnRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIA
 ..  ||..| .||.    ..||.||.|..|||  . .|||..||..  |.|  .|||||||..||.... ..||||.|...| .|||| .||... .| 
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

MLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAqfGCTGPIT
||... |.|.|.|  ||||.. ...| ..|. . |. .....||.....| .. |.|||..||.. ||| | | . |..|||. .|.. ..  .  ||. 
mLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvl

VHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
|||  | |||..|||. ..|.... |. |||. .|| ||  | ...| ||||.||| |..|||
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 1979-2242 1.9e-74 245.6 In-house 22-287 (307) alignment 
Range on Protein: 1979-2242
Range on HMM: 22-287/307.0
SGIDMEFRHLTTLkWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIA
 |.  |...| .   ..  ..|..   |  |||   ....|..||... ..| . |||||||.| ||||.  .|| |.| ..|. |||| |.| .. .| 
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDIN-----TREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFgc
||   .|  ...|. ||| |. || | ..|... |  ...|  ||. .| ..       . | | |.|...|.|.  |..|   |....||.. | .   
mlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..

TGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
 .||.|||  |.||...|.||...|....||. ||.| ||| || .|. ..|  ||| ||| |  .|  
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1979-2241 4.2e-17 56.5 In-house 26-285 (302) alignment 
Range on Protein: 1979-2241
Range on HMM: 26-285/302.0
SGIDMEFRHLTTLKWTSNRCTVANlpVNRPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWIDGYKERGAYIATQAPTNETA---ADFWRAIWEHNSP
. .  || .. |.|   ..|..     |  ||.      .|||.|..     |   .|.||| ..  . .   | .| |. ...   ..|||......  
aevkkefkkidtmkvdlekCkafk..knlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IIAMLVRTNERGQeQCSDYWPLETG--VQVGMLVV-----EPMAEYDmKHYhLREFRISDINTREVRTVRQFHFmeWPDVGKPHTADHFLDFVTQVhnTY
 . .||...|  .   |...|...|  .. | . |     | . |   ..|   |    ..    . .|  ...  |..   |    .    ...|    
svvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.try.viEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv..fa

AQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 .  .. .. .    |||| ..|..| . .... ... . .  .|| .|..| ....  .|| .||.|.  |.
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1980-2245 1.9e-57 189.4 In-house 21-282 (287) alignment 
Range on Protein: 1980-2245
Range on HMM: 21-282/287.0
GIDMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAM
|    |  |  .. . .  |..  . |..|||.   ...| .||...        |||||..||||||. |.|....|  .|| .||. |...| ..| |
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivm

LVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDIN-TREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGcTGPIT
|.. .|  .|.| .||| |. | .|   .| . |  ...|  |....   | . . ..|.|... .|.. || ..    |  . .   |  . |  ..| 
lcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.ntsiv

VHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
|||  . ||.|.|.|  . ... . | |.|||  .|  |  . ...|  |||.|.. .  ||| ...
vhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1981-2245 1.7e-85 281.9 In-house 22-284 (318) alignment 
Range on Protein: 1981-2245
Range on HMM: 22-284/318.0
IDMEFRHLTTLKWTSNRCTVaNLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAML
.. |. .|.  . |. .    . |||. |||    ..||. || .. | |  |||||||..||||... ||||.|||  ||  |||| .|| || .| ||
lseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

VRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGcTGPITVH
 ...|||....  ||| .   . | |||| . | ....| ||||...  .. |.|.|||.|. .||| | |. . ..||.| ||... .. | .|||.||
tqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg.agpivvh

CCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
| .| ||| ||||..|.|.|..|| .|||| ||| ||..|. |.|  .||.|.| .  |.||..|
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
0046845 (Phosphotyrosine protein) phosphatases II 1981-2243 1.3e-84 279.3 In-house 2-276 (284) alignment 
Range on Protein: 1981-2243
Range on HMM: 2-276/284.0
IDMEFRHLTTLKWTSN-RCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGA-DGSDYINASWIDGY-----KERGAYIATQAPTNETAADFWRAIWEHN
.. ||..|. |...    ..||.|| |. |||  . .|||..||... |.|  ..|||||||..|||     . . ..||||.|...| .|||| .||.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SPIIAMLVRTNERGQEQCSDYWPLEtG--VQVGMLVVEPMAEYDMKHYHLREFRISDIN-TREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQ
...| || .. |.|.|.|. ||||| |  .. | . |. . |. ...| .|........ | |.|||..||...||| | |......|.|. .|.. . .
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FGCTGPITVHCCSGAGRTAVFIALSIILDRMRAEH---VVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAA
... ||| |||  | |||..|||| ..|.....|.   .|||. .|| ||. | .|.| .||| |.| |..|||  
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
DSPc_SM00195 1981-2241 5.7e-78 257.2 In-house 2-262 (263) alignment 
Range on Protein: 1981-2241
Range on HMM: 2-262/263.0
IDMEFRHLTTLKWTSnRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAML
...||..| . . .. ..| |. . |. |||    .|||..||..   .. .|||||||..|.|.... .|||||.|...| .|||| .||....||.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

VRTNERGQEQCSDYWPLE--TGVQVGMLVVEPMAEYDMK-HYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFgcTGPI
.. .|.|.|.|..||| |  .  ..| . |. . .  .| ...||.....  ...| |.|.|... .||| | |......|... .|.... .   .|||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

TVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 |||  | |||..|....|||.....|. ||.| .|| ||..| .|.|. |||.|.| |. ||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1981-2241 5.7e-78 257.2 In-house 2-262 (263) alignment 
Range on Protein: 1981-2241
Range on HMM: 2-262/263.0
IDMEFRHLTTLKWTSnRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAML
...||..| . . .. ..| |. . |. |||    .|||..||..   .. .|||||||..|.|.... .|||||.|...| .|||| .||....||.||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

VRTNERGQEQCSDYWPLE--TGVQVGMLVVEPMAEYDMK-HYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFgcTGPI
.. .|.|.|.|..||| |  .  ..| . |. . .  .| ...||.....  ...| |.|.|... .||| | |......|... .|.... .   .|||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpi

TVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 |||  | |||..|....|||.....|. ||.| .|| ||..| .|.|. |||.|.| |. ||.
vVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRN_pd Subfamily PTPRN 1981-2239 3.6e-56 185.1 In-house 31-290 (297) alignment 
Range on Protein: 1981-2239
Range on HMM: 31-290/297.0
IDMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKER-GAYIATQAPTNETAADFWRAIWEHNSPIIAM
.. |.  |.. .   . ..||. . |  |||. ...||| .|| ..    |. ||||||| |     |  ||||||.| ..| ||||. .||. . .| .
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYD-MKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAqfGCTGPIT
| | .| | .||. ||| |     ..  |. ..|.   . | .| | . ...|.| ||| ||||. ||. | | .|  .|.|  .|  .|   | . || 
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpiv

VHCCSGAGRTAVFIALSIILDRM-RAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
||| .||||| |.|.. ..|.|. .  . .|. .|.. || .|.....  .|..| . |  |
vhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN14_pd Subfamily PTPN14 1981-2241 3.7e-50 165.6 In-house 25-296 (300) alignment 
Range on Protein: 1981-2241
Range on HMM: 25-296/300.0
IDMEFRHLTTLKWtSNRCTVANLPVNRPKNRMLSAVPYDSNRVimRLLPGAD-GSDYINASWIDGY--KERGAYIATQAPTNETAADFWRAIWEHNSPII
. .|. ...  .     ...|.||.| .|||.   .||. |||  .| |  .  ..||||| |      ..  ||..|.| . |  |||. .||..  .|
vfteyeripkkre.dallstaklpenaeknrfkdvlPyednrv..elsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli

AMLVRTNERGQEQCSDYWPLE----TGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGC
.|| ...| |.|..  |.| .      |. |   |      | . .  . ...  . ..| |||  . ...||| | |.  ..||... .|.    ..  
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktns

TG-------PITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
.        |. |||  |.||| | |   ...  .  ....|. .... ||. |. ..|   ||.|.| .  .||
eveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1981-2243 3.4e-43 142.5 In-house 17-295 (301) alignment 
Range on Protein: 1981-2243
Range on HMM: 17-295/301.0
IDMEFRHLTTlkWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGAD--GSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIA
.. ....|..   ....|||     |.. ||. . ..|| ||.|..  |  |    .|||||.||||.|. ..||.|.| ..| .|||| ||..    | 
feeqykelke..gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLVRTNERGQEQCSDYWPLET--GVQVGMLVVEPMAEYDMKHYHLREFR-----------------ISDINtrEVRTVRQFHFMEWPDVGKPHTADHFLD
|.  ..|. ...|  |||  .    ..| . |. . |. .  . .|..                  ..  .  . ..| |..  .||. |  .     | 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLq

FVTQVHNTYAQFGcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAA
 . .|  .  . |  ||. |||  . .|. |....|| |.  .|| |||||  .| .|  .  ...  ||| ..| .  .||. 
viddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_CG42327_pd Subfamily CG42327 1981-2169 7.1e-27 88.9 In-house 7-195 (319) alignment 
Range on Protein: 1981-2169
Range on HMM: 7-195/319.0
IDMEFRHLTTLKWTSNrctvaNL-PVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKER-GAYIATQAPTNETAADFWRAIWEHNSPIIA
.  |||.|  |   ..     .. .  ..|.|.. .||    ||...  .  | . |..||.. ||..    |||.|.. .....|||| .|| .| .| 
vaeefrdlPqliarad.....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrviv

MLVRTNERGQEQCSDYWPLETGVQ----VGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFmEWPDVGKPHTADHFLDFVTQVHNTYA
 |.   | | ..|..|.| . . .     | . |        ..| .  . .  ..  | | .  . . .|.. . |     ..  . .|...  
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
0049772 (Phosphotyrosine protein) phosphatases II 1982-2244 5.4e-43 143.3 In-house 22-283 (314) alignment 
Range on Protein: 1982-2244
Range on HMM: 22-283/314.0
DMEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDsNRVIMRLLPGADgSDYINASWIDGYkerGAYIATQAPTNETAADF----------WRAI--
 ... ...   .... ..||.|..|| ||| |  .|.| ||||   ||. . |||||||..||.    ..||||.|...|  ||          || .  
llvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr

WEHNSPIIAM---------------------LVRTNERGqeqcsD-----YWPLETgvqvgmlvvepmaeydmkhyhlrefR-------IsdintreVRT
...|. .| |                     | .  ..|     .     ...|                           .                |.
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.........................eelydpelf.......erl

VRQFHFMEWPDvGKPHTADHFLDFVTQVHNTyaqfGCTGPITVHCCSGAGRTAVFIALSIILDRMRaehvVDVFTTVKLLRTERQ-----NMIQEPEQYH
. ... . .|| | . . ..|..|.  ...        ||. ||| .| |||..|... ... ...    |.. .... .|  |      ..|. .||| 
gikylripvpD.gsaplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqye

FLYLAAYEYLAAY
| . | .|||  .
filealleylkfl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1983-2240 4.6e-71 234.6 In-house 2-255 (284) alignment 
Range on Protein: 1983-2240
Range on HMM: 2-255/284.0
MEFRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVr
.|||... |       | |||. |. |||.   ...| |.| .. | | ..|||||||.| ||. .  ||||| | ..| ||||| |||.|.  | .|  
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

tnergQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISD-INTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHC
     ...||.||||.. .. .   |.  .  . . | .|....|.  . ...|..|||||. |||||.|. . ... .| .|.    .     .| |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

CSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE-Y
 .|.||| |.|.| ..||||. |. |||. .|. || .|....|.  ||.|.| |  | .
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh
subfamily_PTPN13_pd Subfamily PTPN13 1983-2241 1.2e-55 183.7 In-house 15-269 (273) alignment 
Range on Protein: 1983-2241
Range on HMM: 15-269/273.0
MEFRHLTTLKWTsNRCTVANLPVNRPKNRMLSAVPYDSNRVIMrllpGADGSdYINASWIDG--YKERGAYIATQAPTNETAADFWRAIWEHNSPIIAML
 ||..|  || . ..|.|..   |. |||    .|||  ||..    |..|. |||||.|     |..  |||.| |  ||..|||. .|| .. .|||.
eefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvkl....gdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

VRTNERGQEQCSDYWPLETGVQVG--M-LVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAqfgCTGPI
    |.|. .|  ||| ... ..     | || .   ... . .|.. ..|....|.| | ...|..||| | | .|...| ||..| .       .|||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPi

TVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 ||| .| ||. ..|.. ..|. .  .. .||  .|. ||  || ..|  .|| | | |. | |
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1983-2241 1.7e-29 97.8 In-house 20-277 (307) alignment 
Range on Protein: 1983-2241
Range on HMM: 20-277/307.0
MEFRHLTtlKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLlPGAdGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVR
 ||| |.  |.| .  ||  .  |  |||       | .|..... .|.  |||| | ..    .   .|..| | ..|  .||  . ...   . ||..
defrvla..kktpegvtveafsantdknryqdvkcqdkgrivvkf.dgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

TNERGQEQCSDYWPLETGVQVGMLV---VEPMAEYDMKHYHLREFRISD-----INTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHntyaqfGCT
. | .. .| .||||| | .  .        .|.  .|.    |  |         ... ||.... . .||| | |..    ....  |.      . |
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr......ydt

GPITVHCCSGAGRTAVFIALSIILDRMR-AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 |. ||| .| ||.   .|.|.. |.|   .   |.   |. ||..|.  ||.  || .|.    ||.
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1984-2245 2.2e-32 106.8 In-house 16-273 (281) alignment 
Range on Protein: 1984-2245
Range on HMM: 16-273/281.0
EFRHLTTlKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRL-LPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVR
||  |      |. ||| | |||  ||| |     |  || ... .|  . .||| | .|     .  || || | .|| ||||| ||. |.  | ||..
efsnlpg.dppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

TNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTyaqfgCTgPITVHCC
  |  .|.|..|.| .. . . .  .    |       |   |.      | | . .. . ||||   |.... .|  . ...        | |  .|| 
fletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.....st.ppvihcs

SGAGRTAVFIALSIILDRMRAEHV-VDVFTTVKLLR-TERQNMIQEPEQYHFLYLAAYEYLAAYD
.| ||.  ..|. | |. ...     |.   |  || | |   .|  .|| ...    ..  || 
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1985-2239 1.1e-45 150.7 In-house 12-264 (283) alignment 
Range on Protein: 1985-2239
Range on HMM: 12-264/283.0
FRHLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGadgsDYINASWID---GYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLV
.  |  |   .  ...|    |..|||    ||.| .|| .. ..     |||||..|     ||.   ||..|.| ..|  |||. .....   | || 
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

RTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDI-NTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNtyAQFGCTGPITVH
.  |  ...|| ||| .  .. | . |    |.  . .  .|. .     ...   .  . . .| ..|.    . .. |   . .   .    ||| ||
klqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvisl..qteskkgPivvh

CCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
| .| ||||||||.|  .. ...| ||||| .|| .| .|  ..|. .|| ... .. |
CstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG7180_pd Subfamily CG7180 1987-2240 8e-58 190.4 In-house 23-289 (296) alignment 
Range on Protein: 1987-2240
Range on HMM: 23-289/296.0
HLTTLKWTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNER
  .| . ... |  .    || |||    |||| |||... | | . ||||||...|..    .|| |.||..||  .||| ......  . .| .| . 
lkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdf

GQeQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDI----------NTREVRTVRQFHFMEWPD-VGKPHTADHFLDFVTQVHNTYAQF---G
 . .. .||| ..  | | ..|| . |  . . . |.|..              . |.|.|..|.. ||.     |  .  ..... .|.    .     
ak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedp

CTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEY
 .||. |..  ||.|. |..|. . |. .. |. ||||  || || .|...... |.|...|    |.
eegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPN3_pd Subfamily PTPN3 1993-2234 1.3e-54 180.0 In-house 28-268 (280) alignment 
Range on Protein: 1993-2234
Range on HMM: 28-268/280.0
WTSNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRllpGADGsDYINASWID----GYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQ
  .  ...|..| | .|||    .|||. ||...    ..  |||||....    . .    ||||| | ..||.|||. .||..| .| ||  . |||.
kpglaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

EQCSDYWPLET-GVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTyaQFGCTGPITVHCCSGAGR
 .|  ||| ..  .. | . |.   |   | | |||. ..| .|.| |.. |. ...||| | |. ...||.||..|...  . | . |. ||| .| ||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvvhCsaGigr

TAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLY
| |.|.| . |  . |.. | .   |. .|  |....| ..||.|. 
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC
0045098 (Phosphotyrosine protein) phosphatases II 1994-2243 1.5e-73 242.9 In-house 21-274 (278) alignment 
Range on Protein: 1994-2243
Range on HMM: 21-274/278.0
TSNRCTVANLPVNRPKNRMLSAVPYDSNRVImrllpgadgsDYINASWIDGYkeRGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSD
  ...|.|... |..|||. . .|||..||.          ||||||.||||  . ..||||.|...|.||||| .||.....| || .  |.|.| |  
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDI----NTREVRTVRQFHFMEWPDVGKPHTA--DHFLDFVTQVHNTYA-----------QFGCTGP
||| .  .. |...|. . |. ...|.|| ... ..    .. | |.|...|.. ||| | |..   ..||... .... ..           ...  ||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ITVHCCSGAGRTAVFIALSIILDRMraEHVVDVFTTVKLLRTERQN-MIQEPEQYHFLYLAAYEYLAA
. |||  | |||....|. ..|...  |..||.. .|| ||. | . ..| .|||.||| ...|.|  
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRD_pd Subfamily PTPRD 1995-2245 2.6e-107 354.8 In-house 37-285 (564) alignment 
Range on Protein: 1995-2245
Range on HMM: 37-285/564.0
SNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDY
. ....|| |.|..|||.   |.||..||... ..| .||||||||.||||..| ||||||.|..|| .|||| .||.|| .| || ...|.|...|..|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYaQfGCTGPITVHCCSGAGRTAVFIAL
|| ..  ..| |.|....|.....|..|.|.... ...|.|.||||||..||| | |..| ..||....|...  .   .|||.|||..| ||| .||..
WPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.pdagPivVhCSaGVGRTGtfivi

SIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
...|.|...|..||....||.||..|. |.|..|||.|.. | .|.||...
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1995-2245 5.3e-63 207.9 In-house 40-288 (297) alignment 
Range on Protein: 1995-2245
Range on HMM: 40-288/297.0
SNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKErgAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQeQCSDY
    |||.  || .|.|    .||||.||... .     |||.|||.. |.|.   .|.|| | ..| ||||. .....  .|.||   ||| . .|  |
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPH--TADHFLDFVTQVHNTYAQFGCTgPITVHCCSGAGRTAVFI
|. .. .. | ..|. ..  . . .  ||. ..  ...  | |.|..|.||||   ..  .|  .|.....|.... |   . |. ||| .| |||.|..
WsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvll

ALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYD
..  .. ... |. ||.| .|| || || ...|  |||.|.| |  |.| . |
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1995-2241 3.9e-57 188.8 In-house 37-288 (325) alignment 
Range on Protein: 1995-2241
Range on HMM: 37-288/325.0
SNRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLvRTNERGQEQCSDY
.   .|| .| |. |||.   |..| .||..  .  .  |||||||..  .|..  ..|.|||  .|  |.|| . . ..... .|    . |...|. |
giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcavy

WPLE--TGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGK---PHTADHFLDFVTQVHNTYAQ-FGCTGPITVHCCSGAGRT
|| |    .. | | |. ..  ..  |  | . . ...  | |.|.||... |.|.|    | |   .|. | .|...      ...|| ||| .| |||
wpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

AVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 |||.|  .|...  |  ||.|  || || .| .|..  .|| ..| |  |..
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1996-2242 9.7e-59 193.7 In-house 34-278 (315) alignment 
Range on Protein: 1996-2242
Range on HMM: 34-278/315.0
NRCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYW
 | .||  ..| .|||    .|.||.||.. ..     ||||||| | ....  ||||.|.| . .  |||| .....   |.|.   .|  . .|  ||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PL--ETGVQVGMLVVEPMAEYDMKHYHLREFriSDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfgCTGPITVHCCSGAGRTAVFIA
|      |. | . || .          |..     .. | ||| ||.| |||| | .. .  .| .. .|     .   . .. ||| .|.||| |.|.
PdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvis

LSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
.  ...... ...|||| .|| ||..|  ..|  |.| |.| |  |.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1996-2241 5.5e-22 73.1 In-house 25-270 (285) alignment 
Range on Protein: 1996-2241
Range on HMM: 25-270/285.0
NRCTVANLPVNRPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWID-GYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDY
  || .    |   ||       .  ||...        ||| |||.    |.. .||.|| |  || .|||. |.. .   . ||.   | | |.|. |
pnctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPLETGVQV--GMLV--VEPMAEYDMKHYHLREFRISDIN--TREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfgcTGPITVHCCSGAGRT
.| . |  |  |     .    |  .    |  . . . .  . |   . . .   |||   |  |  ....   |..   .     || ||| .| |||
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk...ekpicvhcsagvgrt

AVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
| |. .     |.  .  ....  |. .|. | . .|   |. |||.   ||.
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0040439 (Phosphotyrosine protein) phosphatases II 1997-2241 1.4e-76 252.6 In-house 2-246 (249) alignment 
Range on Protein: 1997-2241
Range on HMM: 2-246/249.0
RCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWP
 ..||.||.|..|||. . .|||..||..  |||  .|||||||.||||.   ..||||.|..|| .|||| .||... .| || .. |.|.|.|  |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

LETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSI
|.. ...|...|. . .. ...|..|....... . |.|||.....  ||| | | . ...|||. .|.. ... .. ||. |||  | |||..|||. .
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

ILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
.|.... |. ||.. .|||||. | ...| |||| ||| |..|.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 1997-2241 3.1e-60 198.5 In-house 31-277 (290) alignment 
Range on Protein: 1997-2241
Range on HMM: 31-277/290.0
RCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWP
. .... ..|. |||    .||| .|| ..   . .|||||||..| | ... .|||.|.|  .|  |||| |||.|  |. |. |  | |. .|  |||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

LETGVQV--GMLVVEPMAEYDMK-HYHLREFRISDIntREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAqfGCTGPITVHCCSGAGRTAVFIA
 |.. ..  | . |. ..|  ..  . .| ...     .| |.|.|||...||| | |..|.. |.....|...        |. ||| .| ||| . ||
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiia

LSIILDRMRAEHV---VDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
. .. . ..||..   .|||  |  ||..|. ..|  |||...| |  |..
idyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN1_pd Subfamily PTPN1 1997-2239 3e-48 159.0 In-house 23-269 (290) alignment 
Range on Protein: 1997-2239
Range on HMM: 23-269/290.0
RCTVANLPVNRPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWP
....|.|| ||..||     |||  |....     .  |||||| ..  . .  || || |  .|.. ||. .||..|  . || .  |..| .| .|||
ptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

LETG---VQVG--MLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVF
 .     ...    | |. ..| . ..| .| ... ...|.| |.. .||.. ||| | |..   ||.|. .| .. .     ||  .|| .| ||.  |
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtf

IALSIILDRMRAEHV---VDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
. .  .| .. ...    ||.  ..  ||  |  .|| ..| .| |||  |
clvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1997-2241 7.5e-47 154.6 In-house 36-236 (392) alignment 
Range on Protein: 1997-2241
Range on HMM: 36-236/392.0
RCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGqeqcsdywp
. |||. ..| .|||    .||||.||.. ..     |||.|||.|....   ||||.|.|   .  |||| ....|   |||. . .|           
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

letgvqvgmlvvepmaeydmkhyhlrefrisdiNTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFgcTGPITVHCCSGAGRTAVFIALSI
                                 .  ..||| |||| |||| . |. .  .| |. .|.  . |.  | |. .||..| |||.| |..  
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqy..thpliihcsagvgrtgvvisids

ILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
.. . .  ..||||  |  .| .|  |.|  ||| |.| |  | |
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1997-2048 3.1e-06 20.8 In-house 38-89 (440) alignment 
Range on Protein: 1997-2048
Range on HMM: 38-89/440.0
RCTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKER
 . .|.|| |. |||. . . || .||..  . |   |||||||.|.| . |
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
0042113 (Phosphotyrosine protein) phosphatases II 1998-2241 2.2e-74 245.2 In-house 1-243 (245) alignment 
Range on Protein: 1998-2241
Range on HMM: 1-243/245.0
CTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPL
..||.||.|..|||  . .|||..||..   .|  .|||||||..|||.  . .||||.|..|| .|||| .||... .| || .. |.|...|  ||||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

ETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfGCTGPITVHCCSGAGRTAVFIALSII
.. ...| ..|. . |. ...|..|....... . |.|.|...|.. ||| | |.. ...|||.  |.. .|. .  ||. |||  | |||..|||. ..
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm

LDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
|.....|. |... .|| ||  | ...| |.||.||| |..|.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 1998-2240 3e-66 218.7 In-house 2-241 (243) alignment 
Range on Protein: 1998-2240
Range on HMM: 2-241/243.0
CTVANLPVNRPKNRMLSAVPYDSNRVIMrllpgaDGSDYINASWIDGYKeRgaYIATQAPTNETAAD----FWRAIWEHNSPIIAMLVRTNERGQEQCSD
...|.||.|..|||  . .||| .||.       .|||||||..|.... |  .||||.|..|| .|    ||| .||... .| || .. |.|.|.|  
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPlETGvQVGMLVVEPMAEYDMKHYHLREFRISDIN-TREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQ------FGCTGPITVHCCSGAG
||| ..  . | ..|. . |. ...|..|..... .. . ..|.|...|.. ||| | | . ...|||. .|.. . .          ||. |||  | |
ywp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTAVFIALSIILDRMraeHvVDVFTTVKLLRTERQN-MIQEPEQYHFLYLAAYEY
||...||. ..|...   . ||.. .|||||. | . ..| |.||.||| |..|.
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1998-2242 1.5e-60 199.8 In-house 35-277 (515) alignment 
Range on Protein: 1998-2242
Range on HMM: 35-277/515.0
CTVANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPL
 |||.  .| .|||    .||||.||.. ..  .  |||.||| | ...   ||||.|.| . .  |||| ....|   |||. . .|  . .|. ||| 
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPd

--ETGVQVGMLVVEPMAEYDMKHYHLREFRIsdINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGctGPITVHCCSGAGRTAVFIALS
     |. | . || ..         |....  .   ..||| |||| |||| | |. .  .| .. .|     |.    |. .|| .|.||| |.|.. 
kpgdsvkfGsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisid

IILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
 .. ...  ..|||| .|. .| .|  ..|  ||| |.| |  |.| 
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2000-2247 2.4e-69 228.3 In-house 3-248 (250) alignment 
Range on Protein: 2000-2247
Range on HMM: 3-248/250.0
VANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEqCSDYWPLET
||. | |. |||.   ...|| ||..    | . |||||||...||.|| |.||||.| ..|  |||| ..|..|  | ||   .| ... ...||| |.
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

GVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGcTGPITVHCCSGAGRTAVFIALSIILD
  . | . |... .  .  |  |.. .|  .  . |.|||.||. ||| | |..|   |.....|. .  | | ..|. |.| .| ||.  |||.. .|.
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqag.naPvivqCsaGvgrsGafiaidavle

RMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAAYDNF
|.. |.|||||  .| ||..| ....  ||| |.| .. ..| .....
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedy
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2000-2241 4.8e-59 194.8 In-house 43-279 (315) alignment 
Range on Protein: 2000-2241
Range on HMM: 43-279/315.0
VANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLEt
||.   |. |||    ..||  || . ||   ..|||.||..||||. .  |||.|.|  ..  |||| ..|..   | ||  . |. ....  ||| . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

GVQVGMLVVEPMAEYDMKHYHLREFriSDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGctGPITVHCCSGAGRTAVFIALSIILD
 |  | . |  . |   ..|  | .  | .   ..|.| |.|.  |||.| |. .  ..... .|.    .    |.| ||| .| |||  ||.|. .||
kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavld

RMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
.. ||...||.  .. .|  |..|.|  |||.|.| |  | .
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2000-2241 8.4e-52 171.1 In-house 42-279 (439) alignment 
Range on Protein: 2000-2241
Range on HMM: 42-279/439.0
VANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQeqcsdYWPLET
.|    ...|||. . ...|  ||... .||   | |||| .|.|| .   |||||.|..||. |||| ..|...  | ||    |  .     ||| ..
laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda

GVQVGMLVVEPMAEYDMKHYHLREFRISDI--NTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfGCTGPITVHCCSGAGRTAVFIALSII
 |  | ..|    . .. .| .| |.. .   .|.  ||| |||.. |||   |  | | |||.  .  .  .   .||. ||| .| |||   ||| | 
evcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdia

LDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
|.....|  ||.   ||.|| .|..|.|.  || |.| |  | .
leqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_ptpA1_pd Subfamily ptpA1 2000-2201 2.1e-26 87.6 In-house 41-256 (418) alignment 
Range on Protein: 2000-2201
Range on HMM: 41-256/418.0
VANLPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERgAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLET
  .   |  |||    .| .  || .. .   .||||||| .|||   .  .|.|| |  .| ||||| .||    || || | .|  . .|  ||| . 
egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

GV-QVGML--VVEPMAEYDMKHYHLREFRISDINTR--------EVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGC----TGPITVHCCSG
|  |. .     | .  | ..   . .    .| ||        | | . |...  |||   |  .. | ...  . |   |         || ||| .|
ggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsag

AGRTAVFIALSIILDRM
 |||  | .  |.. ..
vgrtgtfctavimmkkl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2002-2242 6e-55 181.3 In-house 24-269 (274) alignment 
Range on Protein: 2002-2242
Range on HMM: 24-269/274.0
NLPVNRPKNRMLSAVPYDSNRVIMRLLPGAD-GSDYINASWIDGYKE-RGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLET
... .  |||  . .| .  ||...   . |  |.|||| .| ||.|   ||.||| |  .| ||||| |.......| || . .|. ...|. |.| ..
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

GV----QVGMLVVEPMAEYDMKHYHLREFRISDINTreVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCT-GPITVHCCSGAGRTAVFIAL
..    . | . ..     . ..|..|.. ..  .    |.|  . . .|||   |. |...||.|..|...  .     .|. ||| .| ||| .||| 
dyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

SIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
|| . ..|.|.||||. .|  || .|  |.|. |||.... | ..|| 
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPRK_pd Subfamily PTPRK 2003-2239 8.2e-68 223.5 In-house 40-275 (314) alignment 
Range on Protein: 2003-2239
Range on HMM: 40-275/314.0
LPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVq
   || |||.   ..||  ||..  . |   ||||||..||.||   |.|.|| | .|| .|||| ....|.  | ||    | |. .|. ||| .| | 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

VGMLVVEPMAEYDMKHYHLREFRISD--INTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfgCTGPITVHCCSGAGRTAVFIALSIILDR
 | . || .     . .  | ||..    .  |.|.||||.|. ||| . |. |  .|..| .|... ..    |.| ||| .||||| .|||..|.|| 
ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldm

MRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
.. |.||||| .|| ||... ||..  |||.|.| .. |
ieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2003-2238 5.2e-44 145.2 In-house 5-238 (239) alignment 
Range on Protein: 2003-2238
Range on HMM: 5-238/239.0
LPVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKE-RGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGV
  ||. |||    | || .||..  |     |||||||..  |     ||||||   . .. |||| .|.    .| ||    |  ...| .|||  |  
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk

QVGMLVVEPMAEYdMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVhnTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRM
 . . |    .|  .  | .| | .|..   | | | |.||  ||| | |. |   | .  ..  |   .  . |  .|| .| |||  |. .  .| . 
ycnlrvtlrktev.fadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqa

RAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAY
. .. ||.|  || .| .|  |.|  ||| |..||  
kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2003-2157 1.6e-11 38.3 In-house 93-241 (244) alignment 
Range on Protein: 2003-2157
Range on HMM: 93-241/244.0
LPVNRPKNRMLSAVPYDSNRVImrLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNErGQEQCSDYWPLETGVQ
 | |  |||  ...|.| |||   |  |. |  |||||..        || || |  .|. |||. . |    .. .|   .|  .|   |  |||   .
npnnswknregaglpfdfnrvp..lskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.edeywpdseplewyee

VgmLVVEPMAEYDMKHYHLREFRI-SDINTReVRTVRQFHFMEWPDVGKpHTADHF
   . |      ..|  .  .. | ||.|    ...  |   .||  |     |||
d..itvtltdrdefknikasnleiesdmnes.hqaltmfqisnwpsdgt.tpndhf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2004-2242 9.9e-51 167.3 In-house 18-265 (270) alignment 
Range on Protein: 2004-2242
Range on HMM: 18-265/270.0
PVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKE-RGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGV-
  ..  ||.   .|    ||..  |   . . |||| .. |... . .|||...|.. |  .||| |||.... |.|.   .|.|...|. ||| |..  
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

---QVGMLVVEPMAEYDMKHYHLREFRISdINTREVRTVrQFHFMEWPDVGKPHTAD------HFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFI
   . |.. |  ..|  .. | |.. |.   .  | | |  |.. .||| | |...|      . |  . .|...  ..  ..|. |||  | ||| ..|
vkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

ALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
|| |..  .  .. ||| . .. || .| ...| ||||.||| |  ||  
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2004-2239 4.8e-44 145.3 In-house 5-238 (239) alignment 
Range on Protein: 2004-2239
Range on HMM: 5-238/239.0
PVNRPKNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKE-RGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQ
 ||. |||    | || .||..  |     |||||||..  |     ||||||   . .. |||| .|.    .| ||    |  ...| .|||  |   
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

VGMLVVEPMAEYdMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVhnTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMR
. . |    .|  .  | .| | .|..   | | | |.||  ||| | |. |   | .  ..  |   .  . |  .|| .| |||  |. .  .| . .
cnlrvtlrktev.fadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqak

AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
 .. ||.|  || .| .|  |.|  ||| |..||  |
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2004-2234 2.1e-21 70.8 In-house 50-283 (310) alignment 
Range on Protein: 2004-2234
Range on HMM: 50-283/310.0
PVNRPKNRMLSAVPYDSNRVIMRLLpGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWP-LETGVQ
  .  |||    |  |. || ...   .   ||| | ..     | ..| .| | . |  |||| |..  .  | .|... | |. .|  ||| |     
kkymhknrysdvvcldtsrvklkid.ksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

VGMLVVEPMAEYDmKHYHLREFRI---S-----D---INTREVRtVRQFHFMEWPDVGKPHTADHfldFVTQvhNTYAQFgCTGPITVHCCSGAGRTAVF
 | . |  ..|   . . . .. .         |    | .|.| |   .. .||| | |    |    | |     ||    ||  ||| .| .|. | 
ygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelr.vslikwpnwpdrgvpdekch...tvpq..rllaqv.rhgpcvvhcsagkdrlyvv

IALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLY
.|| . .|...  . ||.   .  |. .|   || . || .. 
valklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2005-2240 2.8e-53 175.6 In-house 37-276 (287) alignment 
Range on Protein: 2005-2240
Range on HMM: 37-276/287.0
VNRPKNRMLSAVPYDSNRVIMRLlPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPL-ETGVQV
 .  |||    .|.| .||..    |  ||||||| .. .|..  |.||.|.|   |  |||||..|..|  .....|  | .. .|  |||  |  ..|
aavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

GMLVVEPMaEYDMK--HYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQV--HNTYAQFG-CTGPITVHCCSGAGRTAVFIALSIIL
|   |  . .||.|  .|  | .|. |..||| | |.|.....||| . . ||  .. || .|  |   |. .  .||. ||.  |.||. ...|. ...
GGysvvll.dydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

DRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEY
.|.     ||| ..|  ||  |. ..| . |. .|| |   |
srledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2005-2241 4.3e-24 79.7 In-house 54-289 (305) alignment 
Range on Protein: 2005-2241
Range on HMM: 54-289/305.0
VNRPKNRMLsAVPYDSNRVIMRLLPGadGSDYINASWIDGY-KERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQV
..  |||    || . . ..    |    |||| | ..         .|..| | ..|  .||  . ...   | ||..| | |. .|..|||.  | ..
iaitknryq.dvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

---GMLVVEPMAE-YDMKHYhlREFRISDINT----REVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHntyaqfGCTGPITVHCCSGAGRTAVFIALS
   . .||| ..    |.     | .|. .|      .  .||.... |||| | |      |.... .       |   || ||| .| |||   .|. 
elksgivvenvsgskpmerd..aeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaie

IILDRMRAEHV-VDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 ||...  ..    .   || || .|   ||.  || |..    .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
Y_phosphatase Protein-tyrosine phosphatase 2006-2237 4.3e-70 231.1 Pfam-A 1-233 (235) alignment 
Range on Protein: 2006-2237
Range on HMM: 1-233/235.0
NRPKNRMLSAVPYDSNRVIMrllPGADG-SDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWP--LETGVQ
|. |||  . .|||..|| .    | .| ||||||....||||  ..||||.|...| .|||| .|.... .|.||.. .|.|.|.|..|||   |. ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VGMLVVEPM-AEY-DMKHYHLREFRISDINTR-EVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYaqFGCTGPITVHCCSGAGRTAVFIALSIILD
 | . || .  |  |.|.| ||...... ... | |.|.|.|. .||| | | .....||....|...     ..||..|||  |.|||..|.||.|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAA
...||. |||. .|| ||..|..|.|. ||| ||| | 
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 2006-2237 4.3e-70 231.1 In-house 1-233 (235) alignment 
Range on Protein: 2006-2237
Range on HMM: 1-233/235.0
NRPKNRMLSAVPYDSNRVIMrllPGADG-SDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWP--LETGVQ
|. |||  . .|||..|| .    | .| ||||||....||||  ..||||.|...| .|||| .|.... .|.||.. .|.|.|.|..|||   |. ..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

VGMLVVEPM-AEY-DMKHYHLREFRISDINTR-EVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYaqFGCTGPITVHCCSGAGRTAVFIALSIILD
 | . || .  |  |.|.| ||...... ... | |.|.|.|. .||| | | .....||....|...     ..||..|||  |.|||..|.||.|.|.
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAA
...||. |||. .|| ||..|..|.|. ||| ||| | 
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0041856 (Phosphotyrosine protein) phosphatases II 2006-2241 2e-44 146.7 In-house 1-171 (182) alignment 
Range on Protein: 2006-2241
Range on HMM: 1-171/182.0
NRPKNRMLSAVPYDSNRvimrllpgadGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVrtnergqeqCSDYWPletgvqvgm
|..|||    .||| .|          ..|||||....|.     .||||.|...| |||.| ..|..  .| .|          .  |||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

lvvepmaeydmkhyhlrefrisdinTREVRTVRQFHFMEWPDVGKPHtADHFLDFVTQVHNtyaqfgCTGPITVHCCSGAGRTAVFIALSIILDRmraeH
                         ... |.. |.... ||| | |   |..|||. .|..        ||. |||  | |||....|. ... .    .
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....g

vVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYL
 |... .|||.|  | .|.. |.|| ||.||..|.|
.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2006-2235 6.7e-42 138.3 In-house 3-233 (237) alignment 
Range on Protein: 2006-2235
Range on HMM: 3-233/237.0
NRPKNRMLSAVPYDSNRVIMRLlPGADgSDYINASWIDGYKER-GAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPL-ETGVQV
|. |||. . | || .||...  .|.. ||||||....|.      |||.| | . .  |||. .|. .  .| ||    |. ...| .|||  .     
nkiknrygnivaydhsrvvlkg.agsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GMLVVEPMAEYDMKHYHLREFRISD-INTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMR
|.| |    . ..  | .| . .|  .. .||| . |..|  ||| | |  .  .| |  .. |       .||  .||..| |||..|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYL
 ..|||..  |. .  .|  .||  .|| |.. 
ekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2006-2239 3.5e-34 113.0 In-house 33-293 (297) alignment 
Range on Protein: 2006-2239
Range on HMM: 33-293/297.0
NRPKNRMLSAVPYDSNRVimRLLPGADGSDYINASWIDGYKERG--AYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLE--TGV
   |||    . .|..||  .|| .  ..||||| ..   .|     || .| |...|  |||. ..|..  .|.|. . .| |...|  |||     . 
slrknryrdilatddtrv..kllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

QVGMLVVEPMAEYD--MKHYHLREFRIsdINTREVRTVRQFHFMEWPDVGKP---HTADHF--------------LDFVT--------QVHNTYAQFGCT
. | .||| ....    .. .| |...  |   | | ||   |. ||| | |   .  . |              |  |         |.    |.    
kagdvvveflsstsdefdrviltelql..iyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprn

GPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
 .. ||| .| ||. | .   .||...| ... || . .. || .|  ..|  ||...|| |. .
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2006-2238 4.6e-10 33.6 In-house 47-276 (303) alignment 
Range on Protein: 2006-2238
Range on HMM: 47-276/303.0
NRPKNRMLSAVPYDSNRVIMrllpgADgSDYINASWIDGYKERGAyIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQ---
|  |||.   .  |  .| .     .| | || ||...   .. | | || | . ||||||. | | .   . .|.  .|  .      .| .       
nmdknrfvdvicldhskvkl.....sd.ssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfe

VG-MLVVEPMAEYDMKHYHLREFRISDINTREVrtVRQFHFMEWPDVGKPHT-ADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDR
   . | |      .. . |.   .|. . .    .   |. .||    |   . .|.  . |.     ..  . |      || ||.  |  .      
ersirvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

MRAE-HVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAY
. .|   .|.   .. .|  |   .|.  |. ..|    
lhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2007-2242 1.1e-23 78.7 In-house 44-272 (288) alignment 
Range on Protein: 2007-2242
Range on HMM: 44-272/288.0
RPKNRMLSAVPYDSNRVIMRllpgADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQ--VG
  ..|       |  || .      |   ||.|  .   | .   | .||| | |   .|. . | .   | || .  |.|.|.  .|.|.. | .  .|
ptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

MLVVEPMAEYD--MKHYHLREFRISDINTREVrTVRQFHFMEWPDVGKPHTADHFLDFVTQVhntyaqFGCTGPITVHCCSGAGRTAVFIALSIILDRMR
 |      ...   |  ..  .|||     .|  |.. |. ||.| | |.    .| ... .        .. || ||.  |.|||. .|   |.|. .|
rlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililialeslr

AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
 .  . . . .. || || . ||   || ...   .|.|.
lddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2008-2239 8.1e-29 95.2 In-house 58-281 (290) alignment 
Range on Protein: 2008-2239
Range on HMM: 58-281/290.0
PKNRMLSAVPYDSNRVIMRllPGADGsDYINASWIDGYKErgAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGV--QVGM
 |||    |  |  |||..   | || ||. | ...| |    .| || ....|. |.|| . ...   | ||    | |. .|..|.| . |     | 
kknrykdvvcndktrvilk..dGydG.dyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

LVVEPMAEYD-MKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNtyaqfgCTGPITVHCCSGAGRTAVFIALSIILDRMRAE
. |    | |  ..  .. . . | ..     .. .. . |||   . ..  .|  .  . .       .||..||| .| |||  |.|. . |. .   
itvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk......asGpvvvhcsaGiGrtGtfvaievglqilldG

HVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
. .|.  .|. ||  | | .|   ||  |  .  .
keldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2008-2240 1.6e-24 81.2 In-house 50-286 (305) alignment 
Range on Protein: 2008-2240
Range on HMM: 50-286/305.0
PKNRMLSAVPYDSNRVIMrllPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGM--
 |||       | ||| .    |.   .|| | ..    .   .| |||| ..| ||||   ....   | ||    |.| ..|..|.. . . .. .  
gknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

----LVVEPMAEYDMKHYHLREFRIS------DINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNtyaqfgCTGPITVHCCSGAGRTAVFIALS
    ..|   .   .|  .  . ...      .    ..| | ..|...||| | | .    |.....           |||.||| .| |||   . | 
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarp......skgpivvhcsagigrtgsvvmle

IILDRMRAEHVVDVF-TTVKLLRTERQNMIQEPEQYHFLYLAAYEY
 |||.. | ....     .. .| .|.| ||  .|| |..    .|
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2008-2085 1.5e-09 31.8 In-house 36-112 (332) alignment 
Range on Protein: 2008-2085
Range on HMM: 36-112/332.0
PKNRMLSAVPYDSNRVimRLLPGADGSDYINASWIDGYKERGAYIATQAPTNE-TAADFWRAIWEHNSPIIAMLVRTNE
  ||.     .| .||   | |     |. ||||.||| .. ||| .||| |. |   ||| . |..  .| ..   .|
dmnriphlycfdhsrv..elapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_egg_pd Subfamily egg 2009-2234 1.8e-17 58.0 In-house 43-263 (307) alignment 
Range on Protein: 2009-2234
Range on HMM: 43-263/307.0
KNRMLSAVPYDSNRVIMRLLPGADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERgqEQCSDYWPLETG--VQV--G
| |       || || ..|  |    |.| |  ..|      .| .|||  .|  |||| ... . . | ||  . |   |.|  |||      ...  |
karskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpG

MLVVEPMAEYDMKHYhLreFRISDINTreVRTVRQFHFMEWPDVGKPHTADHFLDFvtQVHNTYAQfgCTGPITVHCCSGAGRTAVFIALSIILD-RMRA
 | .| .  ..     |  ||.. ..   | . ..  |.|       ...| .  .  .|     .   . |. |..  |  ..|...|. | |   .| 
slrienlkvdskadp.l..frvtklkl..vGgddeerflehwqgdvnnssdvyspl..rvlrklrn..lskpvvvqdilGvskaatlvaieiallsllrG

E-HVVDVFTTVKLLRTERQNMIQEPEQYHFLY
      |  .|..|| .|.  .. . .| |.|
pitkslvlravvflrlrrrlsvesvllylfvy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2009-2096 2.8e-15 50.9 In-house 50-151 (350) alignment 
Range on Protein: 2009-2096
Range on HMM: 50-151/350.0
KNRMLSAVPYDSNRVIMR--------LLPGADGSDYINASWIDGY-----KERGA-YIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDY
|||    .||. .||...              ..|||||...         . .  |||||||. .|  ||.. | . . ..| .|    | . |.|  |
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WP
|.
Wq
subfamily_eak_pd Subfamily eak 2009-2166 2.8e-14 47.2 In-house 55-209 (332) alignment 
Range on Protein: 2009-2166
Range on HMM: 55-209/332.0
KNrMLSAVPYDSNRVimRLLPGA-DGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLET--GVQVGM
.| .. .|||| . |  || .   .   ||||| ..  .    || | .. ..    ||. . | .|| | .|.   | . |.   |.| .|   .. |.
rn.vvkivpydrylv..rltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

LVVEPMAEYDMKHYHLREFRISDINtrEVRTVRQFHFMEWPDVGKPHTADhFLDFVTQVHN
| ||       . .. | . .|  |  |   |  ...  | ..  |   | || .   . .
ldverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpkyed.flalrkvmke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2015-2146 4.7e-07 24.2 In-house 2-122 (130) alignment 
Range on Protein: 2015-2146
Range on HMM: 2-122/130.0
AVPYDSNRVImrllpgadGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNErGQEQCSDYWPLETGVQvgMLVVEPMAEY
|.... .|.         | .|||||..        |. ||.|  .|. |||. . |    .. .|   .|  .|   |  |||   .   ..|      
alefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.edeywpdsePlewyee..diivtltdrd

DMKHYHLREFRISDINTREVRTVRQFHFMEWP
..|. .  ...|..   .  ...  |.  .||
efknikasnleiesdlneshqaltmfqisnwp
0044763 (Phosphotyrosine protein) phosphatases II 2017-2241 1.1e-32 108.5 In-house 1-171 (178) alignment 
Range on Protein: 2017-2241
Range on HMM: 1-171/178.0
PYDSNRVIMRLLPGADGSDYINASWIDGYkergAYIATQAPtnetaADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGvqvgmlvvepmaeydm
|.| .||..  |.|  .|||||||.|...     |.... |     ||... ..|..   | .|  . |.|...|  ||| |.|                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

khyhlrefrisdintrevrtvRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGctGPITVHCCSGAGRTAVFIALSIILDRmraeHVvDVFTTVKLL
                      |.... .|| | |   .|||.||  ... ... |  ||. |||  | ||.....|. ... .    .. ...  ..|.
.....................iqylhipipDhgvpdllehflefvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTERQnMIQEPEQYHFLYLAAYEYL
|  |  ... |.|...||. . ..|
rerRp.ivpnpgqlrqLyefelrll
0046846 (Phosphotyrosine protein) phosphatases II 2025-2241 2.4e-38 127.0 In-house 3-173 (176) alignment 
Range on Protein: 2025-2241
Range on HMM: 3-173/176.0
MRLLPGADGSDYINASWIDGYKergaYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQVgmlvvepmaeydmkhyhlref
.|||    ..|||||..|.|..    .||||.|...| |||.. ..|..  .. .|    | |. .| .|||.......                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

risdintrevrtvrQFHFMEWPDVGKPHTaDHFLDFVTQVHNTYAQfGctGPITVHCCSGAGRTAVFIALSiildRMRAEHVVDVFTTVKLLRTERQ-NM
              |.... ||| | |   ...|... .... . . |  ||. |||  | |||....|.      .. |. ..|. ...|.|  |  ..
..............qylhlpwpDhgvpdl.elllellefirealke.g..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplga

IQEPEQYHFLYLAAYEYL
.| ||||.||| .....|
vqtpeQyrflyefellll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2031-2242 1.1e-10 35.7 In-house 64-277 (312) alignment 
Range on Protein: 2031-2242
Range on HMM: 64-277/312.0
ADGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETG-VQV--GMLVVEPMAEYDMK-----HYHLR
 |   || | ..        ...||.| ..|.. ||.      |  | .|.   | | |.|. |     | |..    .  |  .| ..      .   |
gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr

EFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTyaqfgcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQN
 ...    | .   . .. .  ||| | | . |  | ... |..         |.  || .| |||  .. .  ..  .|     .|  .  ||| .|  
vlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd......kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar

MIQEPEQYHFLYLAAYEYLA
 ..   || .   .  |.| 
svrvfpqyvyalrcvlefly
0043147 (Phosphotyrosine protein) phosphatases II 2032-2236 2.7e-40 133.3 In-house 3-156 (172) alignment 
Range on Protein: 2032-2236
Range on HMM: 3-156/172.0
DGSDYINASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTnergqeqcsdywpletgvqvgmlvvepmaeydmkhyhlrefriSDINT
.||||||||..|.|     .||||.|...| ||||| ..|..  .| .| .                                              . .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

REVRTVRQFHFMEWPDVGKPhTADHFLDFVTQVHNTYaQFGCTGPITVHCCSGAGRTAVFIALSIILdrmraeHVVDVFTTVKLLRTERQNMIQEPEQYH
 ..|.. |.... ||| | | .....|.|. .... . .    ||. |||  | |||....|. ..|      . .... .|.|.|. | ...| |.||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

FLYLA
|||  
flyyf
0051429 (Phosphotyrosine protein) phosphatases II 2033-2243 3.8e-48 159.8 In-house 3-227 (272) alignment 
Range on Protein: 2033-2243
Range on HMM: 3-227/272.0
GSDYINASWIDGYKE---RGAYIATQAPTNETAADFWRAiWEHNSPIIAMLVRTNERGQEQCSDYWP------------LETGVQVGMLVVEPMAEYDMK
 |.||||....||     .|.......|.. |||||||  .|..   | .| ...|||...|. |||             .. . .|.|.|  . |. . 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

HYHLREFRISDI-NTREVRTVRQFHFMEWPDVGKPHTAdhFLDFVTQVHNtyaqfgcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVD--------
.|.|||.... . .. |.|.|...|.. ||| | |. |  .|... ....        ||. ||| .| .||....|| ..| .. .| .||        
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLAA
.. .|. ||  | ...| .|||.||| |. |.| .
leeaveelraqrpgavqteeqylflyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 2033-2234 2.8e-43 142.9 In-house 1-163 (174) alignment 
Range on Protein: 2033-2234
Range on HMM: 1-163/174.0
GSDYINASWIDGYKERGAYIATQAPTNetaadFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLetgvqvgmlvvepmaeydmkhyhlrefrisdINTR
||||||||..|..   . .||.|.|..     ||. ..|... .. || . .|.| . | .|||                                  . 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

EVRTVRQFHFMEWPDVGKPHTADhFLDFVTQVHNTYAQfGCTGPITVHCCSGAGRTAVFIALSIILDRMRaEHVVDVFTTVKLLRTERQNMIQEPEQYHF
..|.. |.... ||| | | ..  .|.|| .|.. ... .  ||. |||  | |||....|. ..| ... | .||.. .|. ||. | .|.| |.||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

LY
||
ly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2033-2234 2.8e-12 41.4 In-house 45-252 (290) alignment 
Range on Protein: 2033-2234
Range on HMM: 45-252/290.0
GSDYINASWIDgYKERGAYIATQAPTNET-------AADFWRAIWEHNSPIIAMLVRTNERGQE----QCSDYWPLETG--VQVGMLVVEPMAEYDMKHY
 .||| |. .  . .  . |.||.| ...         .|| .. . ..  . ||   .|. ..    .|. | | . |  .... | |.       .  
nddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddv

HLREFRISdINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTyaqfgcTGPITVHCCSGAGRTAVFIALSIILDRMR-AEHVVDVFTTVKLLRT
  ||  .   . .|  ||    . .| ..  ...   .|. . .|..       . |. |||  |  | |.. |. .    .   .. | .   .| || 
etRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas......ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

ERQNMIQEPEQYHFLY
.|...|...... |  
qralaitsalelafvd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2033-2095 4.5e-07 23.5 In-house 89-153 (349) alignment 
Range on Protein: 2033-2095
Range on HMM: 89-153/349.0
GSDYINASWIDG--YKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYW
  ||||| ..    ..    |||||||   |  ||.. |   . ...  |   .| . |.|  ||
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
0051082 (Phosphotyrosine protein) phosphatases II 2034-2238 8e-31 102.0 In-house 3-150 (151) alignment 
Range on Protein: 2034-2238
Range on HMM: 3-150/151.0
SDYINASWIDGYkergaYIATQAPTNetaaDFWRAIWEHNSPIIAMLVRTNERGqeQCSDYWPLETgvqvgmlvvepmaeydmkhyhlrefrisdintre
|||||.|...|.     ......|..    ||.. ..|..   | .|  . |||   | .|.| .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

vRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNtyaqfgC-TGPITVHCCSGAGRTAVFIALSIILdRMraehvVDVFTTVKLLRTERQNMIQEPEQYHF
 ..|...... ||| | |.. | .|.|. .. .      .  ||. ||| .| |||....|| ..| ..     |....... .|  | ...| ..|. |
.ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflf

LYLAAY
...| .
qlfall
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2037-2238 5.8e-27 89.2 In-house 78-278 (301) alignment 
Range on Protein: 2037-2238
Range on HMM: 78-278/301.0
INASWIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETG--VQVGML--VVEPMAEYDMKHYHLREFRISDINTR
| | ||.   .   .||||.| ..|. |||  .  ..   |.|| .. |. .|.|..| |....  ...|     .. .     |. . |.... |   .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgk

-EVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTyaqfgcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYH
 . |||  . ..||.| | |..  .  |..  | ..        || ||| .| ||.  ||.  ..  .. |.  ...  ..| || .| | .|  .| .
fatrtvthyqysewtdrgvPkshaelfdlmelvkks......ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

FLYLAAY
.. | . 
wmtlGtv
0049260 (Phosphotyrosine protein) phosphatases II 2041-2234 1.4e-34 114.3 In-house 1-143 (152) alignment 
Range on Protein: 2041-2234
Range on HMM: 1-143/152.0
WIDGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWpletgvqvgmlvvepmaeydmkhyhlrefrisdintrevrtvrQF
.||||.   ..||||.|...|.||||| ..|..  .| || .  |.| ..|  |.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFMEWPDVGKPHTADHFLDFVTQVHNTyaQFGCTGPITVHCCSGAGRTAVFIALSIILdrmraeHVVDVFTTVKLLRTERQNMIQEPEQYHFLY
... ||| | |  ....|...  ..    .    ||. |||  | |||....|. ..|      . |... .|.|.|. | .... |.|. |||
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2043-2116 1.3e-09 31.9 In-house 230-301 (440) alignment 
Range on Protein: 2043-2116
Range on HMM: 230-301/440.0
DGYKERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVRTNERgqeQCSDYWPLET-GVQVGMLVVEPMAEYDM
.||  . |.|||| | . |  |||| . ...   | || . |..    || |||..|  |  | . |      .|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenm
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2047-2234 7.6e-20 65.9 In-house 3-197 (199) alignment 
Range on Protein: 2047-2234
Range on HMM: 3-197/199.0
ERGAYIATQAPTNETAADFWRAIWEHNSPIIAMLVrTNERGQE-QCSDYWPLE-TGV-QVGMLVVEPMAEYDMKHYHLREFRISDINTR--EVRTVRQFH
 .  ||||| |  || ||||. .||  |  | |.   ... .| . . |||   .|. . | | |   .      | .  . ...  |     | . .. 
gqrryiatqhplretmadfwqmvwetgsghivmvn.ddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FMEWPDVGKPHTAdHFLDFVT---QVHNTYAQFgCTGPITVHCCSGAGRTAVFIALSIILDRMR--AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLY
|  | .   |  |  |. ||    .| . | |     |. |||  | | | ||.|| | .         |||.|   | ||  |  .|   ..| |.|
ftswkekttpnva.lfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2049-2234 9.5e-20 65.6 In-house 4-196 (198) alignment 
Range on Protein: 2049-2234
Range on HMM: 4-196/198.0
GAYIATQAPTNETAADFWRAIWEHNSPIIAMLVrTNERGQE-QCSDYWPLE-TGV-QVGMLVVEPMAEYDMKHYHLREFRISDINTR--EVRTVRQFHFM
  ||||| |  || ||||. .||  |  | |.   ... .| . . |||   .|. . | | |   .      | .  . ...  |     | . .. | 
rryiatqhplretladfwqmvwetgsghivmvn.ddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWPDVGKPHTAdHFLDFVT---QVHNTYAQFgCTGPITVHCCSGAGRTAVFIALSIILDRMR--AEHVVDVFTTVKLLRTERQNMIQEPEQYHFLY
 | .   |  |  |. ||    .| . | |     |. |||  | | | ||.|| | .         |||.|   | ||  |  .|   ..| |.|
swkekttpnva.lfvgfvvasrevskkyeqe.kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 2054-2235 1e-13 45.4 In-house 96-282 (302) alignment 
Range on Protein: 2054-2235
Range on HMM: 96-282/302.0
TQAPTNETAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQV--GML------VVEPMAEY-DMKHYHLR--EFRISDINTREVRTVRQFHF
   | ..|   .|  | ..|  |.. |.   | ....|..|.  . | ..  |        | . ..|. | |...|   |.. .  ...  .||  ..|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

MEWPDVGKPHTADHFLDFVTqVHNTYAQfgctgPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYL
  ||| | |. |.. || .    ..| .      . |||  | |||  ..|.   ..    ..| |. . |. .|. |   .|. .|  .| |
sawpdhGapkeaytaldilk.fcesykk.....nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 2061-2237 1.8e-13 45.2 In-house 40-217 (255) alignment 
Range on Protein: 2061-2237
Range on HMM: 40-217/255.0
TAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDINT--REVRTVRQFHFMEWPDVGKPHTADHFL
| . |...|   ..  ..||   .| |.|.|| |.|||   .  .  |.  .   . .  ||  .|    .  .. .||. ...  |..   |. |   |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFVTQVHNTYaqfgctgPITVHCCSGAGRTAVFIALSIILD----RMRAEHVV--DVFTTVKLLRTERQNMIQEPEQYHFLYLAA
  .  |...        .. ||| .| ||.| |.   ..       ..  . |  |    .. || .|.  |..| |  |  |  
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv
subfamily_hpo-7_pd Subfamily hpo-7 2061-2236 1.9e-11 38.4 In-house 46-222 (263) alignment 
Range on Protein: 2061-2236
Range on HMM: 46-222/263.0
TAADFWRAIWEHNSPIIAMLVRTNERGQEQCSDYWPLETGVQVGMLVVEPMAEYDMKHYHLREFRISDIN--TREVRTVRQFHFMEWPDVGKPHTADHFL
| . |...|   ..  ..||   || |.|.|| |.|||   .  .  |.  .   ..   |.   .  .    ....||... .  |...  |. |   |
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

DFVTQVHNTyAqfgctgPITVHCCSGAGRTAVFIALSIILD----RMRAEHVV--DVFTTVKLLRTERQNMIQEPEQYHFLYLA
  .  . |         .. ||| .| ||.| |    ..       ..  . |  |    .. || .|.  |..| |  |  | 
nilkvarns.k......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilm
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2090-2221 5.2e-08 26.7 In-house 149-282 (332) alignment 
Range on Protein: 2090-2221
Range on HMM: 149-282/332.0
QCSDYWPlETGVQVGMLVVEPMAEYDMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKphTADHFLDFVTQVHNTYAQF-----GCTGPITVHCCSG
 |  .|| | . .  . ..   |  |    |.. | ..  . .. .    .|| || |  |    ...||. . ..  | .       | ||| . |..|
icrkfwp.ekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhfyewadask..lpeymldmrasiklqyirsskktgvcigpimlvcatg

AGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQ
  . |.. .. ||. |.  || | .  |.  .. .| 
vekcaisatidiivsriteehrvgfketmsaikmqrf
0048179 (Phosphotyrosine protein) phosphatases II 2115-2235 1.2e-20 69.1 In-house 27-139 (144) alignment 
Range on Protein: 2115-2235
Range on HMM: 27-139/144.0
DMKHYHLREFRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAqfgCTGPITVHCCSGAGRTAVFIALSIILdrmrAEHvVDVFTTVK
.......  .. .  .. . |.. |.... ||| | |  ....|.|.  ... ..     ||. |||  | |||....|. ...     .. .... ...
klgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleeala

LLRTERQNMIQEPEQYHFLYL
|.|. | .... |.|..||..
lvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 2124-2240 1.1e-21 72.5 In-house 34-142 (145) alignment 
Range on Protein: 2124-2240
Range on HMM: 34-142/145.0
FRISDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfgcTGPITVHCCSGAGRTAVFIALsiilDRMRAEHvVDVFTTVKLLRTERQNM
.....  . ..|.. |.... ||| | |  ....|.|. .... ...    ||. |||  | |||....|.    . |. .. |... ...|.|. | ..
lnltselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgtlvaa....ylmlllg.vsleealelvrsqrpga

IQEPEQYHFLYLAAYEY
.. |.|..|||.. .|.
vpnpgqlrflyefelel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2127-2245 9.8e-22 71.9 In-house 81-198 (440) alignment 
Range on Protein: 2127-2245
Range on HMM: 81-198/440.0
SDINTREVRTVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGcTGPITVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQE
| ||  | ||..|.|.  ||| | |. |   | .. .| ..  . |  ||. |||..|||||.| ||.  ||   .    .|.|. .. .| .| .|.| 
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqt

PEQYHFLYLAAYEYLAAYD
|||| |.. |  | | . |
peqyafvheavlegllcgd
PTPc_DSPc_SM00012 2136-2237 5.3e-30 99.1 In-house 1-103 (105) alignment 
Range on Protein: 2136-2237
Range on HMM: 1-103/105.0
TVRQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILDRMRAE-HVVDVFTTVKLLRTERQNMIQEPEQYHFLY
||...|...||| |.|...|..|... .|.. . . . ..|. |||  |.|||..|.||.|.|.....| . ||.| .|| ||..|..|.|. ||| |||
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

LAA
 | 
ral
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2136-2241 1.9e-09 31.7 In-house 216-344 (350) alignment 
Range on Protein: 2136-2241
Range on HMM: 216-344/350.0
TVRQFHFMEWPDVGKPHTADHFLDFVT--------QVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILD-----RMRAEH---------VVD-VFTT
 | |...  |.|..       .|  .          . ... .   . || ||| .| ||| ....|  .|      ..  ..         . | .. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VKLLRTERQNMIQEPEQYHFLYLAAYEYL
|. ||  | .|.|. .|. |.| |.  | 
vnelrkqrismvqnldqfifiYeallfyf
0038934 (Phosphotyrosine protein) phosphatases II 2138-2236 6.2e-08 28.0 In-house 80-172 (194) alignment 
Range on Protein: 2138-2236
Range on HMM: 80-172/194.0
RQFHFMEWPDVGKPHTADHFLDFVTQVHNTYAQfGCTGPITVHCCSGAGRTAVFIALSIIL-DRMRAEHVVDVFTTVKllrterQNMIQEPEQYHFLYLA
 ... . .|| | . . .  |.|.  |.  ...    | . |||  | |||....|  .|   .| ||  .. |. ..      ...|. ..... |.  
ieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR......pgaipnqdyleallkr
subfamily_PTPDC1_pd Subfamily PTPDC1 2140-2232 8.9e-07 23.5 In-house 85-167 (182) alignment 
Range on Protein: 2140-2232
Range on HMM: 85-167/182.0
FHFMEWPDVGKPhTADHFLDFVTQVHNTYaQfgcTGPITVHCCSGAGRTAVFIALSIIL-DRMRAEHvvdvftTVKLLRTERQNMIQEPEQYHF
.. . |.| | . . .. || |  |. .  |    | ..||| .| ||| | ||  ..  .|. ||.      ..||.| .| . ||  || ..
vynfgwkDygva.sleriLdivkvvafal.q...egkvavhChaGlGrtGvliacylvyakrltaek......aiklvrskrpksiqtreqvel
0048567 (Phosphotyrosine protein) phosphatases II 2144-2210 4.8e-06 21.0 In-house 44-114 (157) alignment 
Range on Protein: 2144-2210
Range on HMM: 44-114/157.0
EWPDVGkPHTADHFLDFVTQVHNTYAQFG-CTGPITVHCCSGA---GRTAVFIAL-SIILDRMRAEHVVDVF
 . | | | . ... .|...... . ..  . ..| |||. |.   ||||..|..  |.  .. .| ... .
fffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiapl
subfamily_PRL_pd Subfamily PRL 2153-2233 8.6e-07 23.1 In-house 70-142 (151) alignment 
Range on Protein: 2153-2233
Range on HMM: 70-142/151.0
TADHFLDFVTQVHNTYAQFGCTgPITVHCCSGAGRTAVFIALSIILDRMRAEHVvdvfttVKLLRTERQNMIQEpEQYHFL
. .   .... ....... . .  ..||| .| ||. |..||..| . |. |.       |...|..|.. | . .| .||
peevveeWlellkekfkeepks.tvavhcvaGlGraPvlvalalieaGmkyeda......vefirekrrgains.kqlkfl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2163-2242 1.7e-06 21.6 In-house 254-345 (349) alignment 
Range on Protein: 2163-2242
Range on HMM: 254-345/349.0
QVHNTYAQFGCTGPITVHCCSGAGRTAVFIALSIILD--RMRAEHVVD----------VFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
.  . | .   . .. ||| .| ||| |.. | ..|.   .  .. .           .. .|  ||  | .|.|.  |. ..| |  .|.|
lfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_CG42327_pd Subfamily CG42327 2174-2242 7.5e-15 49.4 In-house 247-316 (319) alignment 
Range on Protein: 2174-2242
Range on HMM: 247-316/319.0
TGPITVHCCSGAGRTAVFIALSIILDRMRAE-HVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYEYLA
 ||..|||  |.||| . ||  | . ..    . ||.  .|  .| .| . ... ||| |.|  ..|| .
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 2178-2239 4.3e-12 40.3 In-house 2-63 (69) alignment 
Range on Protein: 2178-2239
Range on HMM: 2-63/69.0
TVHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
 ||| ||.|||  |||. . . |...| .||.|  |. .|  |  |. .  .| |.. |  |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 2179-2239 3.1e-12 40.7 In-house 2-62 (69) alignment 
Range on Protein: 2179-2239
Range on HMM: 2-62/69.0
VHCCSGAGRTAVFIALSIILDRMRAEHVVDVFTTVKLLRTERQNMIQEPEQYHFLYLAAYE
|||.||.|||  |||. . . |...| .||.|  |. .|  |  |. . ..| |.. |  |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve