Gene R06B10.1 in Caenorhabditis elegans

Synonym: CELE_R06B10.1, R06B10.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP167_AA protein Get Run
CeleP167_AA_896-1149 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
WSN Domain of unknown function 98-164 3.8e-26 80.8 Pfam-A 2-68 (69) alignment 
Range on Protein: 98-164
Range on HMM: 2-68/69.0
ELSKSVNQMHMISRIINGIYLQQSLVNNTIPSEELISELLNIGSLTTSQIVGINGAKLTTVVDQINQ
||.........|.|..||||||. | |..||....|.||||||| ..||...|. .|| . ......
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 875-1127 3.4e-15 50.3 In-house 13-265 (302) alignment 
Range on Protein: 875-1127
Range on HMM: 13-265/302.0
ERFSEYIKgQVLWCCQETVTILTDWVIGHEKDQRYTVSmfANSQNALVGYGKRFVDgyihAsKVIFPNNLRMILTQSPQHKT-----------KTRNSTI
| | ||.. . |. ...... ...  | . . . .      ..   ||.. . |..    | .|.  .... |..| |   |           . ..||.
eefleyve.raleklkkktstnlekdiserrkslfice..pktmaklvdfkndfin....a.nvlkldeikwimaqGpmdGtekkekvskkpivpkkstl

EKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQ---KSMEFDDEGEVRQLLVKF-----DDQPEFTIEHLWYRG
||.| .  | .   .||||. .|       |  . ||||     |||.||   .|. |.   .  || |  ...   |..      .. ..|.. | . .
ekhwalieqynvaivvqlcsfve.......deekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQmipgLTSDQSDRDILYVLLRMRA
| |   |. ..  ||.|   ..  . |.||| .|. ..  .  |    |    | | .   |.| ..| .|.
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiq....lcskkkvtdllsivlpvrq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 891-1175 2.8e-123 405.7 In-house 7-289 (290) alignment 
Range on Protein: 891-1175
Range on HMM: 7-289/290.0
ETVTILTDWVIGHEKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFPNNLRMILTQSPQHKT-KTRNSTIEKFWWMAMQERSKSIVQLCENMEPTH
..|.. ||.| .||.|||..|.........| ||||||.|.||||..|..||.||.|||||||.|. ..||||||||||||.||..|..|.|||..|...
tavllktdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksa

NLDWdTseACAEYVPLAEGGEIKFDGGSVRCvqKSMEFDDEGEVRQLLVKFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNG
|... .  |||.||| ..|.|.||.| .|.|  ||.|..|. |.|.|.|||||. |||..| ...||... |.|..|..|.|..||....|||||||..|
ntsl.f..aCakYvpesvgeelkfkgltvkC..kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdG

ISKSACFAYIELACQMIPGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALYGVFMRLMEVG--FFEEASKKKPRAERSTTIIAASSM
||.||..|.|.|..|.|........ .|.|..|...||... ... ..|...|......||.  |.||...||..||...|.......
iSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeeketykkikql
0040438 (Phosphotyrosine protein) phosphatases II 897-1176 5e-49 162.7 In-house 38-305 (317) alignment 
Range on Protein: 897-1176
Range on HMM: 38-305/317.0
TDWVIGHEKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFPN-NLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDT
. ..  ..|..   . .. .|   |  .|... ..||.|| | .|| . ..|.||.|.      ..|.|.||.| .......|| |.| .|       . 
aelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl......pntvedFwrmvweqgvtvivmLtelee.......lg

SEACAEYVPLaeGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN----TTPVIVHCKNGI
 | ||.| ||  |....... .|....     ... ..|.| |.  .|....|. |..| || |  ||.||...||.|..|...     .||.|||..|.
rekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGv

SKSACFAYIELACQMIpGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALYGVFMRLMEVGFFEEASKKKPRAERSTTIIAASSMI
.....|. ..|.....   . . .  .... | ..|. ...... | |  . ... |. .. .|.||..| .  . ....| ... 
gRtGtfiaaylmleql.ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk
0039614 (Phosphotyrosine protein) phosphatases II 897-1145 2e-40 134.5 In-house 51-287 (297) alignment 
Range on Protein: 897-1145
Range on HMM: 51-287/297.0
TDWVIGHEKDQRYTVSMFANSQNALVGYGKR-FVDGYIHASKVIFPN--NLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHnLdw
. ..   .| .   . .. .|   | ..... . . ||.|| | ...  . ..|.|| |...      |.|.||.|  ......|| |.. .|  .    
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe......tvedFwrmvweqgvtvivmLtklvelgr.k..

dtseaCAEYVPLAEGgeiKFDGGSVRCVQKSMefDDEGEVRQLLVKFdDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT------NTTPVIVHCK
     ||.| |  .|   .... .|....  .  .|   ||.| |.  .....|. |..| || |  ||.|....|..|..|..      . .||.|||.
.....caqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCs

NGISKSACFAYIELACQMIpGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALYGVFM
.|......|. . |.....   . . .  ...  | ..|  .... . | |  . ...
aGvgRtGtfiaaylmleql.ekeggvdvleavkelreqRpgavqtpsqyrflydalle
0040439 (Phosphotyrosine protein) phosphatases II 898-1144 6.4e-41 136.0 In-house 7-243 (249) alignment 
Range on Protein: 898-1144
Range on HMM: 7-243/249.0
DWVIGHEKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFPN-NLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPthnldwdTS
 ..  ..|.. . . .. .|.  |  ....| ..||.|| . ... . |.|.|| | ..      |.|.||.|  ......|| |.. .|.         
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe......tvedfwrmlwelgitvivmLtslvel.......gr

EACAEYVPLaeGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT------NTTPVIVHCKNG
| ||.| ||  ||...... .|....  .   |.  ||.| ...  |....|. |..| .| |  ||.|....||....|..      . .||.|||..|
ekcaqywpl..ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

ISKSACFAYIELACQMIPgLTSDQSDRDILYVLLRMRAECFPNYQLYSFALYGVF
......|. . |.....   . . .  ...  | ..|  ...|.. | | .. ..
vgRtGtfiaaylmleqle.kelgvdleeavkllrsqRpgavqnpeqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 899-1145 3.5e-40 134.0 In-house 52-302 (307) alignment 
Range on Protein: 899-1145
Range on HMM: 52-302/307.0
WVIGHEKDQRYTVSMFANSQNALVGYGKR-FVDGYIHASKVIFP---------NNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPt
..  ..| .   .  . ...  |  ....   ..||.|| |..|         .....|.||.|...      |.|.||.|  ..... || |.| .|  
lpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe......tvedFwrmlweqgvtvivmltelvel.

hnldwdTSEACAEYVPLAeGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF--DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT------NTT
      ..| ||.| |.  |.|. ..   |... ..   .|.  ||.| |.    .....|. |..| || |  ||.|....||....|..      . .
......grekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkgg

PVIVHCKNGISKSACFAYIELACQMI--PGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALYGVFM
||.|||. |.. ...|. . |.....   | ..| . ....  | ..|  ...|.. | |  . ...
pvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 899-1141 8.2e-39 128.9 In-house 6-237 (245) alignment 
Range on Protein: 899-1141
Range on HMM: 6-237/245.0
WVIGHEKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFPN-NLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSE
..  ..| . . . .. ...  |  .| .....||.|| | ... . ..|.|| |...      |.|.||.|  ......|| |.| .|       .  .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe......tvedfwrmlwelgittivmLteeee.......lgrv

ACAEYVPLaeGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT-----NTTPVIVHCKNGIS
 ||.| ||  |....... .|...      .|.  ||.| |.   | ..... |..| .| |  ||......||.|. |..     . .||.|||. |..
kcaqywpl..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvg

KSACFAYIELACQMIpGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALY
 ...|. . |.....   . . |  .... | ..|  .... . | |  .
RtGtfiaaylmleql.ekelgvsleeavkelrsqRpgavqtpsqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 899-1144 7.3e-38 126.1 In-house 46-283 (288) alignment 
Range on Protein: 899-1144
Range on HMM: 46-283/288.0
WVIGHEKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIF-PNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSE
..  .|| . . .  . .|   |  ...   ..||.|| . . ... ..|.|| |       ..|.|.||.| ...... || |.. .|       .  |
lpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl......pntvedFWrmvweqnvrvIvmltklve.......lgre

ACAEYVPLaeGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF-----DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN----TTPVIVHCKN
 || | ||  || ....  .|...   .  .|.  ||.| |.       |. ..|. |..| .| |  ||.||. .||.| .|..       ||.|||..
kcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsa

GISKSACFAYIELACQMIPGLtSDQSDRDILYVLLRMRAECFPNYQLYSFALYGVF
|......|. ..|.....       .  ...  | ..|  .... . | |  . ..
GvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0043336 (Phosphotyrosine protein) phosphatases II 900-1141 2.2e-39 131.0 In-house 43-271 (278) alignment 
Range on Protein: 900-1141
Range on HMM: 43-271/278.0
VIGHEKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFPN-NLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEA
.  ..| .   .  . .|   |  .|... ..||.|| | ..| . ..|.|| |...      |.|.||.|  ......|| |.| .|       . .. 
penkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......tvedFwrmvwelgvttivmLtelve.......lgrvk

CAEYVPlaeGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT----NTTPVIVHCKNGISKS
||.| |   || ..... .|...      .|   ||.| |.   | ...|. |..| || |  ||||....||.| .|..    . .||.|||..|....
caqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRT

ACFAYIELACQMIpGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALY
..|. ..|.....   .   .  ...  | ..|. .... . | |  .
Gtfialyllleql.ekeggvdleeavkelreqRpgavqtpsqyrflye
DSPc_SM00195 904-1139 4e-38 126.6 In-house 28-254 (263) alignment 
Range on Protein: 904-1139
Range on HMM: 28-254/263.0
EKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFP-NNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPthnldwdTSEACAEY
.|..   . .. ..   |    |.  . ||.|. . .. .. ..|.|| |.      .||.|.||.| ..|..| || |.|..|         .| |..|
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......pstvedFWrmvweekvkiivmlteeeen.......gkekcdry

VPLAEGGEIKFDGGSVRCVQKSMEFdDEGEVRQLLVKFDDQ-PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN----TTPVIVHCKNGISKSACFA
.|  .||. .|.  || .|..  .  || ..|.| ......  ........|..|.|. ||.|.| .|.|| .|..     ..|..|||..|......|.
wpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfv

YIELACQMIPGLTSDQSDrDILYVLLRMRAECFPNYQLYSFA
 |..... .   . .. . .|.  |   |. .. . . |.|.
tidiilskleeekkvdif.eivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 904-1139 4e-38 126.6 In-house 28-254 (263) alignment 
Range on Protein: 904-1139
Range on HMM: 28-254/263.0
EKDQRYTVSMFANSQNALVGYGKRFVDGYIHASKVIFP-NNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPthnldwdTSEACAEY
.|..   . .. ..   |    |.  . ||.|. . .. .. ..|.|| |.      .||.|.||.| ..|..| || |.|..|         .| |..|
sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......pstvedFWrmvweekvkiivmlteeeen.......gkekcdry

VPLAEGGEIKFDGGSVRCVQKSMEFdDEGEVRQLLVKFDDQ-PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN----TTPVIVHCKNGISKSACFA
.|  .||. .|.  || .|..  .  || ..|.| ......  ........|..|.|. ||.|.| .|.|| .|..     ..|..|||..|......|.
wpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfv

YIELACQMIPGLTSDQSDrDILYVLLRMRAECFPNYQLYSFA
 |..... .   . .. . .|.  |   |. .. . . |.|.
tidiilskleeekkvdif.eivkelRkqRpgmvqtleqYlfi
Y_phosphatase Protein-tyrosine phosphatase 905-1139 5.3e-45 149.0 Pfam-A 3-229 (235) alignment 
Range on Protein: 905-1139
Range on HMM: 3-229/235.0
KDQRYTVSMFANSQNALV-GYGKRFVdgYIHASKV-IFPNNLRMILTQSPqhktktRNSTIEKFWWMAMQERSKSIVQLCENMEPthnldwdTSEACAEY
| .||.  . ....   . |....    ||.|. |  .... ..|.|| |       .||||.||.| .||..|.||.|....|         .|.||.|
kknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgP......lkstiedFWrmvwqekvkvivmltsleek.......grekcaqY

VPLAEGGEIKFDGGSVRCVQKSMEFDDEGEVRQLLVKFDDQPE--FTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNT----TPVIVHCKNGISKSACF
.| .|... ...  .|....|. | ..|  .|.| .| .....  .....|.| .|.|. |||||| .|||..||....    .||.|||..|......|
wpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtf

AYIELACQMIPGltS-DqsdRDILYVLLRMR---AECFPNYQLYSFA
. ........      .    |.| .. ..|   .... ... | | 
valdilleqlea..eee...vdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 905-1139 5.3e-45 149.0 In-house 3-229 (235) alignment 
Range on Protein: 905-1139
Range on HMM: 3-229/235.0
KDQRYTVSMFANSQNALV-GYGKRFVdgYIHASKV-IFPNNLRMILTQSPqhktktRNSTIEKFWWMAMQERSKSIVQLCENMEPthnldwdTSEACAEY
| .||.  . ....   . |....    ||.|. |  .... ..|.|| |       .||||.||.| .||..|.||.|....|         .|.||.|
kknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgP......lkstiedFWrmvwqekvkvivmltsleek.......grekcaqY

VPLAEGGEIKFDGGSVRCVQKSMEFDDEGEVRQLLVKFDDQPE--FTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNT----TPVIVHCKNGISKSACF
.| .|... ...  .|....|. | ..|  .|.| .| .....  .....|.| .|.|. |||||| .|||..||....    .||.|||..|......|
wpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtf

AYIELACQMIPGltS-DqsdRDILYVLLRMR---AECFPNYQLYSFA
. ........      .    |.| .. ..|   .... ... | | 
valdilleqlea..eee...vdvlqivkelRkqRpgmvqsleqYifl
0037934 (Phosphotyrosine protein) phosphatases II 909-1141 7e-30 99.8 In-house 17-236 (243) alignment 
Range on Protein: 909-1141
Range on HMM: 17-236/243.0
YTVSMFANSQNALvgYGkrfvDGYIHASKVIFPNnlRMILTQSPQHKtkTRNSTIEKFWWMAMQERSKSIVQLCENMEPTHNldwdtseACAEYVPlaeg
...  . .|.  |   |    ..||.|. .  ..  |.|.|| |  .  | ... ..|| |  ......|| |.| .| ...        ||.| |    
sdilpydhsrvkl..eg....sdyinanliyvtp..rliatqgPlpe..tveddlasfwrmlwelgitvivmltelvElgre.......kcaqywp....

GEIKFDGGSVRCVQKSMefDDEGEVRQLLVKF--DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVN------------TNTTPVIVHCKNGISKSA
||. ... .|.... .    |.  || ||..    |...... |..| .| |  ||.||...||.||.|.             .  ||.|||. |.....
gevtygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

CFAYIELACQMIpgltsDQSDRDILYVLLRMRAE-CFPNYQLYSFALY
... . | ....     . .  ...  | ..|   ...... | |  .
tliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflye
subfamily_PTPRB_pd Subfamily PTPRB 911-1127 2.3e-15 51.4 In-house 60-262 (293) alignment 
Range on Protein: 911-1127
Range on HMM: 60-262/293.0
VSMFANSQNALVGYGKRFVDGYIHASKVIFPNNL-RMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtsEACAEYVPLAEGG
.  . .|.  |    ..  . || |. .   |     | || | ..      |...|| | ....|. || | . .|  .       . | || |  |  
ilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe......tvddfWrmvwekkssiivmltqlvekgk.......vkCeeYWPadeep

EikfDGGSVRCVQKSMEFDDEGEVRQLLVKFdDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNT------TPVIVHCKNGISKSACFAYIELAC
      |...   .. |  ..  .|.|...  .. | ..... .  | |  |||..| .||.. .|....      .|..|||  |. ..  |  ..   
v...lyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

QMIPGltsdQSDRDILYVLLRMRA
| |      .   ||. .. ..| 
qaiee....edyvdifgivaelRe
0047943 (Phosphotyrosine protein) phosphatases II 916-1143 2.3e-37 124.4 In-house 52-268 (273) alignment 
Range on Protein: 916-1143
Range on HMM: 52-268/273.0
NSQNALvgygKRFVDGYIHASKVIFPN-NLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGG-EIKF
.|   |    .   ..||.|| | ..| . ..|.|| |       ..|.|.||.| ...... || |.| .|       .  | || | || .|. ....
hsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPl......pntvedfwrmvweqnvrviVmLtelve.......lgrekcaqYwpleggelslty

DGGSVRCVQKSMefDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT------NTTPVIVHCKNGISKSACFAYIELACQMI
.  .|...      .|   ||.| ... ... ..|. |..| || |  ||.|....|.....|..      . .||.|||..|......|. ..|.....
gkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldql

pGLTSDQSDRDILYVLLRMRAECFPNYQLYSFALYGV
   .   .  .... | ..|  ...... | |  . .
.ekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 916-1102 1.8e-11 38.7 In-house 62-239 (319) alignment 
Range on Protein: 916-1102
Range on HMM: 62-239/319.0
NSQNALVGYGKRFVDGYIHASKV-IFPNNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHnLdwdtseACAEYVPLAEggeiKFD
... .|  .       || || .  . .. . | ||.| ..      ||| || |  .|.|  .| |..  |. . .       . .| | ..      .
rtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen......tiedfWrmvWeeessivvmltklveklk.v......klkkywpeen....fee

GGSVRCVQKSMEFDDEGEVRQLLVKFDDQPE--FTIEHLWYRGWKDRLVPESPKIMLDLLDKVN-----TNTTPVIVHCKNGISKSACFAYIELA
.| .    .. |  .. ..|.| ..   .     .. |  |  | |  |||. . .|||| ...     |.  |..||| .|. .   |  .. .
yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldam
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 919-1120 2.3e-06 21.6 In-house 54-251 (287) alignment 
Range on Protein: 919-1120
Range on HMM: 54-251/287.0
NALVGYGKRFVDGYIHASKVI-FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAeGGEIKFDGGS
  |.    ..   || |  |  . .. . | .|.|        .|. .|| . ...|| |.. .  ..|       ..   | .| |      ..  | |
rvllsaegelGsdyinanyvasytddeafiaaqgPi......aatvrdfwravletrsasvitmtreve.......earlkcykywPer.evPmrvGGys

VRCVQKSMEFDDeGEVRQLLVKFDDQPE-FTIEHLWYRGWKDRLVPES----PKIMLDL-----LDKVNTNTTPVIVHCKNGISKSACFAYIELACQMIP
|  .....   .   || | .   .  |   .. | .  | |. .. .     . .||      | .  ... |..||.. || .|  .  .    ..  
vvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrle

GLTSDQSDRDILY
 |      . ...
dlGrvdvaavvir
0045098 (Phosphotyrosine protein) phosphatases II 920-1141 4.4e-34 113.5 In-house 41-266 (278) alignment 
Range on Protein: 920-1141
Range on HMM: 41-266/278.0
AL--------VgygkrfvdGYIHASKVIFPnNLRMILTQSPQHktktrnSTIEKFWWMAMQERSKSIVQLCENMEPThnldwdtSEACAEYVPlaEGGEI
          .        .||.|| . .. . ..|.|| |        ||...|| |  ......|| |.| .| .        | ||.| |  ||| .
dilpydhsrVk........dYINAsyidgy.pkkfIatqgPlp......stvadfwrmlwelgitvivmltelvelg.......rekcaqywp..eggsl

KFDGGSVRCVQKSMEfdDEGEVRQLLVKF-----DDQPEFTIEHLWYRGWKDRLVPESP--KIMLDLLDKVNT-----------------NTTPVIVHCK
 ... .|.... ..   |.  .| |||        | ......||.| .| |  ||..|  | .|.||. ..                  . .||.|||.
tygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCs

NGISKSACFAYIELACQMIpglTSDQSDRDILYVLLRMRAE-CFPNYQLYSFALY
 |.. ..... . | ....    .  .  ...  | ..|   ...| . | |  .
aGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflye
subfamily_PTPRN_pd Subfamily PTPRN 921-1105 9.6e-12 39.2 In-house 75-250 (297) alignment 
Range on Protein: 921-1105
Range on HMM: 75-250/297.0
LVGYGKRFVDGYIHASKVI--FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPlAEGGEIkFDGGSV
|    ..  . || || ..   | .   | ||.|       .||. .|| |  .. .  ||.|..  |       .  ..|..| |  || |. ..   |
lkeeasaeksdyinasaildhdprapayiatqgpl......astvadfwqmvweqGvvvivnltrlee.......egvkqckrywp.deGsev.yhiyev

RCVQKSMEFDDEgEVRQLLVK-FDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT----NTTPVIVHCKNGISKSACFAYIELACQM
. | . .  ||   || . .| .. .   |.  . .  |... || |.| .|..  |||      ..|..||| .|  .. ..  |.| .. 
hlvsehiwcddy.lvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnr
0041856 (Phosphotyrosine protein) phosphatases II 924-1144 2.9e-19 64.8 In-house 13-168 (182) alignment 
Range on Protein: 924-1144
Range on HMM: 13-168/182.0
YGKRFVDGYIHASKVIFPNNL-RMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCenmepthnldwdtseaCAEYVPlaeggeikfdggsvrcvq
|    .  ||.|. ....    |.|.|| |  .      |...|. |  ... ..|| |.                .  | |                  
ydhsrdldyInanlylgslpatrfiatqgplls......tvadflrmlkelgittivnlt................eelywp..................

ksmefddegevrqllvkfdDQPEFTIEHLWYRGWKDRLVPEsPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQMipgltsDQSDRDILYVL
                   .  | .. ...| .| |  ||. . ..||....|. .  ||.|||. |........ . | ...      . | ....  .
...................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklv

LRMRAECFPNYQLYSFALYGVF
 ..|  .. . . | |  . ..
rsrRpgmvitpnqyfflqlall
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 924-1106 3.8e-09 30.5 In-house 73-250 (310) alignment 
Range on Protein: 924-1106
Range on HMM: 73-250/310.0
YGKRFVDGYIHASKVIfPNNLRM--ILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKfdgGSVRCV
  |   . ||||  |   | ||   | .| |  .      ||  || | .|||..||. ||  .|       .    |  | |     |     | .|  
idksryedyihanyvk.tnylrstficsqgplqh......tiidfwrmifqeraesilllckvge.......egrpkcvgywpslgvtety...gcirvt

QkSMEFDDEGEVRQLLVKF-------DDQP----EFTIEHLWYRGWKDRLVPESPK--IMLDLLDKVntNTTPVIVHCKNGISKSACFAYIELACQMI
.   |  .| |. .| | |       |.||    |. .. . .  | || ||.     .   || .|     |..|||  |. .  . . ..|. . .
n.lsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 925-1141 1e-19 65.4 In-house 68-281 (305) alignment 
Range on Protein: 925-1141
Range on HMM: 68-281/305.0
GKRFVDGYIHASKVIFPNN-LRMILTQSPQHKTktrnstIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCV--
   .   ||||  |  | |  |.| ||.| .||         ||.| .|.. ..|  ||. .|         .. |.|| .  .. ...|. .  . .  
egpwpheyihanyvstptnpkrfictqaplekt......cadfwymclqdkveaifmlcnlle.......kgakkcleyfaskdkdvlefeekgqkisvk

---QKSMEFDDEGE--VR--QLLVKFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELAC-QMIPGLTSDQ
    ....| .. .  |.  .|...   .    . |  .  | || || .   .|.|| |  .   |..|||  || ..     .|  . |.. |   ..
fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiied

SDRdILYVLLRMRAECFPNYQLYSFALY
.|. ||  .   | .     . | |   
tdk.ilqkireqrnnsiqtdaqylfvhq
subfamily_eak_pd Subfamily eak 926-1105 3.1e-07 24.1 In-house 74-237 (332) alignment 
Range on Protein: 926-1105
Range on HMM: 74-237/332.0
KRFVDGYIHASKVIFPNNL-RMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFdgGSVRCVQKS
..  .||| || . |..   . |||  ..      .. .  || | ....| .|||| |..|          |    | |     |.||  | .   .|.
qlnrlGyinaslaefsevGrkyiltGias......edkvfafwqmvleqkspaivqlledve.......lkleksdkyfpdktreelkf..Gildverke

MEFDDEGEVRQLLVKFDDQpEFTIEHLWYRGWKDRLVPESPKIMlDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQM
    .  |.|.| ..  ..    . |  . || .  .|     .  | . .    .. ..  |. . .|    ||     .
fvkrniletrllelskGne.thrvlhykvfGwtettlpkyedfl.alrkvmkevGvlllivmksallsstlkkyihtppsf
subfamily_egg_pd Subfamily egg 927-1111 5.4e-17 56.4 In-house 65-234 (307) alignment 
Range on Protein: 927-1111
Range on HMM: 65-234/307.0
RFVDGYIHASKVIF-PNNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPthnldwdtsEACAEYVPLAEGGEIKFDGGSV--RCVQK
...| .||| .|   |    .||.|.|         | . || | .||. . || |  . |.         | |  | | ||   ...  ||.   ... 
qylddfihanrvkGkpllnefilaqaplkn......tvddfwrmvfqeevqyivmltsrkes.........erceyywpkaesdslvtvpGslrienlkv

SMEFDDEGEVRQLLVKFDDQPEFTIEHlWYRGWKDRLVPESPkimLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELA-CQMIPGLTS
  . |    | .| .   |. |  .|| |   ..      ||   | .| |.   ..||.|....|.||.|..  ||.| .... | . 
dskadplfrvtklklvGgddeerfleh.wqgdvnnssdvysp...lrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpit
0036941 (Phosphotyrosine protein) phosphatases II 928-1159 7.7e-46 152.1 In-house 61-289 (297) alignment 
Range on Protein: 928-1159
Range on HMM: 61-289/297.0
FVDGYIHASKVIFPN-NLRMILTQSPQHktktrnSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSME
  ..||.|| | ... . ..|.|| |..      .|.|.||.| .......|| |.| .|       .  | ||.| || ||....... .|...  .  
egsdYinAsyvdgydlkrkfIatqgPlp......ntvedFWrmvweqnvtvIvmltelve.......lgrekcaqywpleegesltygdftvtllsvevv

FDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT------NTTPVIVHCKNGISKSACFAYIELACQMIPG--LTSDQSDRD
..|.  .|.| |.. ......|. |..| || |  |||||...||....|..      . .||.|||..|...|..|. ..|..|.. .   .   .  .
llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdile

ILYVLLRMRAECFPNYQLYSFALYGVFMRLMEVGFFEEASKK
..  | ..|. ...... | |  . ... |. . ..|...|.
avkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0046845 (Phosphotyrosine protein) phosphatases II 928-1146 7.6e-37 122.6 In-house 55-273 (284) alignment 
Range on Protein: 928-1146
Range on HMM: 55-273/284.0
FVDGYIHASKVIFP------NNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAeGGEIKFDGGSVRCV
  ..||.|| | ..      .. ..|.|| |  .      |.|.||.| ...... || |.| .|       .  | || | ||  |. ..... .|...
edsdYinAsyvdgydldltyikkkfIatqgPlpn......tvedFwrmvweqnvrvIVmltelve.......ngrekcaqYwple.gevltygdftvtll

QKSMefDDEGEVRQLLVKFD--DQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN------TTPVIVHCKNGISKSACFAYIELACQMIPGL--TS
 . .  .|   || | ...   .....|. |..| .| |. ||.||...|..|..|..         |..|||..|......|. ..|.....     ..
seev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglll

DQSDRDILYVLLRMRAECFPNYQLYSFALYGVFMR
  .  .... | ..|  .. ... | |  . ... 
gvdvleavkrlreqRpgmvqtleqyrfvyealley
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 928-1108 4.8e-18 60.2 In-house 65-239 (307) alignment 
Range on Protein: 928-1108
Range on HMM: 65-239/307.0
FVDGYIHASKVIF-PNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPTHnLdwdtseACAEYVPLAEGGEIKFDGG----SVRC-V
    ||||  .    .  ..| .| |.      ..|. .|| ||.||. .|.. ||. .| .. .       | .| || || .  |       ||    
lasdyihanylgiaikpkkficaqgpl......entqysfwamaiqekvesvimlckvielak.i......kceqywpleegqklvfgeapntisvanlg

QKSMEFDDE-GEVRQLLVKFDDQpEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELA-CQMIPG
 | .  |..  .| .| |.. ..   ||.|| .  | || ||.     ..||. |. .| ||.|||  |. .|     | |   .|| |
akklapdedlinvttlkvdwaqk.srtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaG
0050432 (Phosphotyrosine protein) phosphatases II 929-1144 6.4e-40 132.8 In-house 90-296 (308) alignment 
Range on Protein: 929-1144
Range on HMM: 90-296/308.0
VDGYIHASKVIFP---NNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEG-GEIKFDGGSVRCVQKS
 ..||.|| | ..   .. ..|.||.|       ..|.|.||.| ...... || |.. .|       .  | ||.| || .| | ..... .|...   
gsdYInAsyvdgyssklprkfIatqgPl......pntvedFwrmvweqnvrvIvmLtklve.......ngrekcaqYwplelgggsleygkftvtllsee

MefDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN--TTPVIVHCKNGISKSACFAYIELACQMIPGLtSDQSDRDILYV
.  .|.  ||.| ... .|....|. |..| .|.|  ||.||.|.||.|..|..     |..|||..|......|. ..|.....       .  .... 
v..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkk

LLRMRAECFPNYQLYSFALYGVF
| ..|. ...... | |  . ..
lReqRpgmvqtpeqylflyrall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 929-1126 5.4e-11 37.5 In-house 53-231 (284) alignment 
Range on Protein: 929-1126
Range on HMM: 53-231/284.0
VDgYIHASKVI-FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCenmepthnldwdtSEACAEYVPLAegGEIKFDGGSVRCvqKSMEF
 | || || .  . .. . | || |.      . |.. || |  . .. .|| |               . |..| ||   ..|| . . |.   .|.| 
sd.yinasfitGyqrkdkyiatqGPl......dntladfWrmiweyncstivllt.............kdkcsqywplk..ivikeerfkvkv..dsvee

DDEGEVRQLLVKF--DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVN------TNTTPVIVHCKNGISKSACFAYIELACQMIpgltSDQSDRDIL
 .|  ||.. .      .   .|    ..|| |  ||..|  .. |..||.       . ....|||  |. ..  .  ..   ...     ...  |. 
seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrm....keekqvdvy

YVLLRMR
 ..  .|
nfvrdlr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 929-1101 4.7e-10 34.1 In-house 78-239 (297) alignment 
Range on Protein: 929-1101
Range on HMM: 78-239/297.0
VDGYIHASKVIfPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwdTSEACAEYVPlaEGGEIKFdgGSVRCVQKSMEFD
   |. || |   |. |.| || |.      ..|.. || | ..|. . || | .. |        . . || | .  . |  .|  |.|  | .|..  
dsDyvnasfvk.gnkhrlittqmPm......katvadfWamvldeqvstivmlnddne........rdkkcaryWs..dkgvttf..Gdvsvvllsvser

DEGEVRQLLVKFDD-QPEFTIEHLWYRGWKDRLVPE--SPKIMLDLLDKVN----T-NTTPVIVHCKNGISKSACFAYIEL
  .  |.| |. .. . .  ..   .  | |. |..  | . .|.|.. |.    . . .|..||| .|. . . .  |. 
eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids
subfamily_PTPN14_pd Subfamily PTPN14 929-1102 4.9e-10 33.9 In-house 75-252 (300) alignment 
Range on Protein: 929-1102
Range on HMM: 75-252/300.0
VDGYIHASKVIFP---NNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSM
 .||| ||..  .   ...  | .|.|...      |...|| |  ..  . ||.| |. |       |  | . .|.|  |  . . . |  . ..|  
stgyinassikvsvggkersyivaqgPlel......tvqdfWqmvWeqgvqlivmlteeee.......dgkeksfkyfPkleskkktvefgkfkvttkfs

EFDDEGEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT------N-------TTPVIVHCKNGISKSACFAYIELA
|  |    ..| .|.   . | |. || |  | |. ||| .| .|. |..|.       .         ||.||| .|. ..      .| 
edsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 929-990 3.6e-07 23.9 In-house 74-133 (302) alignment 
Range on Protein: 929-990
Range on HMM: 74-133/302.0
VDGYIHASKVIFP-NNLRMILTQSPQHKTKtrnSTIEKFWWMAMQERSKSIVQLCENMEPTHN
 | |..||||  |  .  .||.| |. ...   . .|.|| |..||. .|.| |  . | .. 
pdsyvnaskvevPeltrsiilaQlpkvdse...dsveeFWrmvfqekivsvvilvgeeelkkt
subfamily_CG7180_pd Subfamily CG7180 929-1101 9.8e-07 22.7 In-house 70-245 (296) alignment 
Range on Protein: 929-1101
Range on HMM: 70-245/296.0
VDgYIHASKV-IFPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPTH-NLDWDTSEACAEYVPLAegGEIKFDGGSVRCVQKSME
 | || |. |  |  .   | |. |.      ..|...|| .  .| ....| |..... ..  ...   .. ..| ..    ||         ... . 
sd.Yinavyvdsflkkkeyivteapk......ketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeif..veiveekqyanlkirtfk

FDDEGEVRQLLVKFDDQPEFTIEHLWYRGWKD-RLVPESPKIMLDLLDKVN---------TNTTPVIVHCKNGISKSACFAYIEL
   .        |  . .. .. .. .. |.    || | . ...|. .|.          .. ||.|....| |.|  .  |. 
ltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaida
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 930-1106 1e-22 75.2 In-house 80-248 (305) alignment 
Range on Protein: 930-1106
Range on HMM: 80-248/305.0
DGYIHASKVIFP--NNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHNldwdtseACAEYVPLAEGGEIKFDGGSVR---CVQKS
  ||||  |  |   . |.| .| |  .      ||..|||| .|.. . || ||  .|  .         ||.| |.| |   .. .| |       | 
sdyihanyvgcpmipekrficaqgpldq......tidefwwmviqnkveqivmlcktvelgkl.......kcaqywpaaqgeklelksgivvenvsgskp

MEFDDEGEVRQLLVKFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQMI
|| | | ..  | . .  . .... || .  | || ||      |.||  .     |..|||  || ..     ||   . |
merdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyileki
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 930-1107 3.1e-20 67.0 In-house 66-228 (281) alignment 
Range on Protein: 930-1107
Range on HMM: 66-228/281.0
DGYIHASKVIFPNNLR-MILTQSPQHKTKTrnstieKFWWMAMQERSKSIVQLCENMEPThnldwdtSEACAEYVPLAEGGEIKFDGGSVRCVQKSMEfd
  ||||  .  |   |  |||| |...|..       || |  || . .|| ||. .|          | ||||.|      ..||  ||   . ...  
tdyihanyirspflkrgyiltqgpkketra......dfwrmiwqenttaivmlcqfletn.......rekcaeyfprnahcclqfdklsvsyedstvn..

DEGEVRQLLVKFDDQPEFtIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQMIP
      .| . .. .  . | |  .. | |  |||| ..|| .| |. . .|| ..||  |. .|  .  .|.| | | 
kslvttrlnlsyegetrl.ithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsih
subfamily_PTPN23_pd Subfamily PTPN23 930-1127 1.4e-19 65.0 In-house 67-257 (288) alignment 
Range on Protein: 930-1127
Range on HMM: 67-257/288.0
DGYIHASKV--IFPNNLRMILTQSPQHktktrnSTIEKFWWMAMQERSKSIVQLCENMEPThnldwdtSEACAEYVPLAEGGEIKFDGGSVRCVQKsMEF
| || || |  . |    .| ||.|..      ||.  || | ....|. || | .. |          . ...| | ..|   ||.  || . ..  | 
DDYinAsfvkdlspgcPdfiatqaPlq......stlnDFWlmvyeqkssviVmllskeelg.......kpkvdrYwPedkgetvkfgdlsvtlksv.ret

DdEGEVRQLLVKFDDQPE-FTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT--------NTTPVIVHCKNGISKSACFAYIELACQMIpglTSDQSDRDI
. .   |.| ... |. .  .. || .  | .  ||.||. .|..||.|..          ||..|||  |. ..  || .  | . .   . ..   ||
e.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel...ekgnglldi

LYVLLRMRA
. |. |.|.
iqvvsrlre
subfamily_PTPN12_pd Subfamily PTPN12 930-1127 1.9e-17 58.1 In-house 68-254 (290) alignment 
Range on Protein: 930-1127
Range on HMM: 68-254/290.0
DGYIHASKVIFPN-NLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtsEACAEYVPLAEGGEIKFDGGSVRCVQKSMeFD
..|| |. .  .. .|. | .|.|  |      |.. || | .. . . .| .|...|  .         |. | |   . |..|.  .| . .. . .|
sdYinanfikgvegkleyiaaqgPLpk......tlddfWrmiweknveivvmaCrevelgk.......kkCerYWpeegeeelefgefevtleeeka.vd

DEGEVRQLLVKFDdQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT----NTTPVIVHCKNGISKSACFAYIELACQMIPGlTSDQSDRDILYVLLR
|.  .|.| |... . . ... . |. | |. ||.|.| .|.|...|..    . .|..|||  |. .      |... ...      ... |.  ..|.
ddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka.ekipeeldvfdlvle

MRA
.| 
lrk
0051082 (Phosphotyrosine protein) phosphatases II 930-1140 3.5e-17 57.9 In-house 3-146 (151) alignment 
Range on Protein: 930-1140
Range on HMM: 3-146/151.0
DGYIHASKVIfPNnlrMILTQSPqhkTKtrnstieKFWWMAMQERSKSIVQLCENMEPThnldwdtseACAEYVPLAEggeikfdggsvrcvqksmefdd
..||..| |  ..   ..... |   .         |. .  ..  |.|| |.. .|.           |.||.| ..                      
sdyinfsyvt.gg...lyrsggp...la.......dflellkelgiktivnlrseeerg.........ycpeylpelg......................

egevrqllvkfddqpeFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN-TTPVIVHCKNGISKSACFAYIELACQMipgltsdQSDRDILYVLLRMRAE
                ... |... .|.|  .|.|....|..|.... .   ||.|||. |.. ....... | ...        |  ..|  ....|  
................ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpg

CFPNYQLYSFAL
..   | . | |
vvqpnqqflfql
0051429 (Phosphotyrosine protein) phosphatases II 930-1140 1.4e-16 56.5 In-house 4-218 (272) alignment 
Range on Protein: 930-1140
Range on HMM: 4-218/272.0
DGYIHASKVIFPnnLR------MILTQSPQHKTktrnstIEKFWWMaMQERSKSIVQLCENMEPTHNL-DWDTSEACAEYVPLAEGGEIKFDGGSVRCVQ
.|||.|. |  .   |       .... | . |      .. ||..  ... |.|| |.. .|  ..  |.    .   ..|. . ..     | .|   
sgyiNardvggy..grvvkpgrlyrsggplplt......aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtl

KSMEFDDEGEVRQLLVKF--DDQPEFTIEHLWYRGWKDRLVPESPkiMLDLLDKVNTnTTPVIVHCKNGISKSACFAYIELACQMIP-------GLTSDQ
 |.|. .   .| ||...  . .  ... ||.|..| |. ||...  .|.||. ...   ||.|||. |.. ..... . |  . ..        | ...
lseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

SDRDILYVLLRMRAECFPNYQLYSFAL
  ....  | ..|.  ..... | | .
yleeaveelraqrpgavqteeqylfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 930-1149 2.6e-13 44.6 In-house 59-268 (285) alignment 
Range on Protein: 930-1149
Range on HMM: 59-268/285.0
DGYIHASKVIFPNNL--RMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSMEf
  ||||| . .| .     | || |  .      |.  || |  ||.   .. ||  .|          | || | |   |  .||    .   .   | 
rdyihaswmrmpgkdqstyittqgplpe......tlsdfwhmiyqekiayvlmlctlfe.......ggvekcalyypeklgevvkfgkyeitlteckee.

DDEGEVRQ-LLVK-FDDQ--PEFTIEHLWYRGWKDRLVPESPKIMLDLL---DKVNTNTTPVIVHCKNGISKSACFAYIELACQMIpgltSDQSDRDILY
   | . . | |   .|     . ..|.    | |.| ||  . |..|     ||| . .|. |||  |. ..| |  |. |   |     .. . ..| 
aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatiri....menpniemld

VLLRMRAECFPNYQLYSFALYgVFMRLME
..  |||  |   | .   |. ... |||
ivremramrfqavqshmqflf.lyvvlme
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 930-1126 2.5e-11 38.0 In-house 76-259 (290) alignment 
Range on Protein: 930-1126
Range on HMM: 76-259/290.0
DGYIHASKVI-FPNNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAeGGEIkFDGGSVRCVQKsMEFD
. ||.|. .  . .. . |.||.| ..      |. .|| . .||..  || |.. .|       . .. |  | | . . .  ..  |.. ..  ....
neyinAcyikgykekkqyiatqgpvsn......tlvdFWkliwqekvtiivmltniie.......egkvkCqqYWpds.dtka.ygefsikllne.etln

dEGEVRQLLVKFDDQ--PEFTIEHLWYRGWKDRL-VPESPKIMLDLLDKVN----TNTTPVIVHCKNGISKSACFAYIELACQMIpgltSDQSDRDILYV
 |   |.| || ...  .. .. ..    |..   |..   |.| .   ..    .  |...||| .....|| |  .. . .        .   |.. |
.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkc....ktegvidvfqv

LLRMR
| ..|
lksqR
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 930-1106 5.5e-11 37.3 In-house 90-251 (319) alignment 
Range on Protein: 930-1106
Range on HMM: 90-251/319.0
DgYIHASKVI-FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCenmepthnldwdtSEACAEYVPLAegGEIKFDGGSVRCvqKSMEFD
| || || |  . .. . | .| |.      . |.. || |  . .. .|| |               . |..| ||   ..|| . . |.   .|.|  
d.yinasfvtGyqrkdkyiaaqGPl......dntladfWrmiweyncstivllt.............kdkcsqywplk..ivikeerfkvkv..dsveet

DEGEVRQLLVKF--DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVN------TNTTPVIVHCKNGISKSACFAYIELACQMI
.|  ||.. .      .    |    ..|| |  ||..|  .. |..||.       . ....|||  |. ..  .  ..   ...
aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 931-1106 1.2e-21 71.7 In-house 82-243 (290) alignment 
Range on Protein: 931-1106
Range on HMM: 82-243/290.0
GYIHASKVIFpNNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKsMEFDDE
 |.||  |    .  .|||| . ..      |.  .| | .||.   || ||| .|       |    |..| |  ||  . |   .| | ..  . |..
dyvhanyvkG.lkamfiltqGalkd......tvidiwrmvlqekvaaivmlcelie.......dGkakceqyypekeGevltfGeitvlcsee.ddkdan

GEVRQLLVKF-DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQMI
   . | |.  |.  |  . ||  . | |. |. |   .| .|  . . . ||.|||  || ..  |. || . |..
iikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqil
subfamily_PTPN1_pd Subfamily PTPN1 931-1127 1e-18 62.1 In-house 57-248 (290) alignment 
Range on Protein: 931-1127
Range on HMM: 57-248/290.0
GYIHASKVIFPNNL-RMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEG-GEIKFDGGSVRCVQKSMEFD
 || || | ...   . |||| |  .      |.. || |  ...||..| | . .|         .  ||.| |  |   |....  ...    | |  
dyinaslveleeakrsyiltqGPlpn......tvdhfWqmvWeqkskavvmlnkvve.......keqikcaqywPqgeeekellledtklkvkliseerk

DEGEVRQLLVK-FDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKV------NTNTTPVIVHCKNGISKSACFAYIELACQMIpGLTSDQSDRDILYV
..  ||.| ..    |   .| |  |  | |  |||||  .|..| ||      ...  |...||  || .|  |. ..     |   . |.|  ||  |
syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli.ekkddlssvdikkv

LLRMRA
|| .| 
llelrk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 931-1132 1.8e-16 55.0 In-house 68-253 (288) alignment 
Range on Protein: 931-1132
Range on HMM: 68-253/288.0
GYIHASKVIF-PNNLRMILTQSPqhktkTrNSTIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtsEACAEYVPLAEGGEIKFDGGSVRCVQKSMEFDD
 ||.|  |   ... |.| .|.|       |.|||..| | ...  . || ||| .|  .       |. ||| |.  | ....        .|  . | 
fyiaanvvssakykrrlicaqaP.....l.ngtieelWkmllesdveyivmlcellekGk.......eksaeyfPsklGekarigrlctvvkkkradidk

EGEVRQLLVKFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIELACQMIPglTSDqsDRDILYVLLRMRAEC
  .|  | ..   . .  . .| .. |.|  |||. .  | ||. ... . |..||...|. ... .. | .| ...    .|  .  |  .| ..|.| 
lvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslr..ldd..flgirsllaklreer

FPN
|  
fka
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 931-1128 7e-15 49.9 In-house 70-254 (281) alignment 
Range on Protein: 931-1128
Range on HMM: 70-254/281.0
GYIHASKVI-FPNNLRMILTQSPQHktktrnSTIEKFWWMAMQERSKSIVQLCENMEPTHnLdwdtseACAEYVPlAEGGEIKFdgGSVRCVQKSMEFDD
 || |. |  . .. . | ||.|        .....||.| .... . || . ...|  . |       |  | |  .  |.|.  | |.  ... |   
DYinanfvpgykgekeyiatqgPvP......aslvafWqmvweqkvsaivmvtreieagk.l......kChrYWP.ddnselky..gdvtvkstaeeeka

EGEVRQLLVKFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKV----NTNT-TPVIVHCKNGISKSACFAYIELACQMIPgltSDQSDRDILYVLLR
.   |.. .. .. .. ..|.| |  | |  ||...| .|.  ..|    ...| .|...||  |. .. ..  .. ... .    ..... |.  |.  
tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave...aeleeldvkavvae

MRAE
.| |
lrke
0049772 (Phosphotyrosine protein) phosphatases II 931-1136 1.7e-14 49.8 In-house 73-269 (314) alignment 
Range on Protein: 931-1136
Range on HMM: 73-269/314.0
GYIHASKVIFPnnLRMILTQSPqhktktRNSTIEKF----------WWMA--MQERSKSIVQ---------------------LCENMEPThnldwdtSE
.||.|| |  .  |. | || |      .. |.. |          | |    . ..  ||                      |.. ....       .|
dyinasyvdgf..lkfIatqgp......leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......ne

ACAEYVPLAEggeikfdggsvrcvqksmefddegevrQ-------LlvkfddqPEFTIEHLWYrGWKDRLVPeSPKIMLDLLDKVNT--NTTPVIVHCKN
 .|....| .                           .       .       ..  |..|..  . |  .| ........|. ...  . .||.|||| 
ptaadlellk...........................eelydpelf.......erlgikylri.pvpDgsap.lledfdeflefieeadkggpvlvHCka

GISKSA--CFAYIELACQmipgltsDQSDRDILYVLLRMRAeCFPNYQL------Y
|.. ..  ..|.. . ..       . | ...|  . ..|  . ||  .      |
GkgRtgtfvvaaylmkll.......gvsleealedvrlkRp.inpnpgfieqleqy
subfamily_PTPN13_pd Subfamily PTPN13 931-1126 2.5e-11 38.3 In-house 61-245 (273) alignment 
Range on Protein: 931-1126
Range on HMM: 61-245/273.0
GYIHASKVIFP---NNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHNldwdtseACAEYVPLAEGGEIKFDGgSVRCVQKSMEF
||| || .  |   .. ..|..| |  .      |.. || |  . ... |. .  . |  .         |  | |  .. ..|  .  ..  .  .. 
gyinaslikvpvgkdeyeyiacqGPlPe......tvkdfwqmvweqkaeviamvtlekekgkv.......kchrywPesknkklkvsn.rlevellkvqk

DDEGEVRQLLVKFDDQPE-FTIEHLWYRGWKDRLVPESPKIMLDLLDKV---NTNTTPVIVHCKNGISKSACFAYIELAcqmiPGLTSDQSDRDILYVLL
 |.  ||.| ||  .  |   . || .  | |  || |.. .| .. .|   .|...|..|||  || .|  .  |. .     || . . . |.  .. 
ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv....lglierdkefdvkeivr

RMR
..|
klr
subfamily_PTPN9_pd Subfamily PTPN9 931-1098 7.1e-08 26.8 In-house 71-242 (297) alignment 
Range on Protein: 931-1098
Range on HMM: 71-242/297.0
GYIHASKVI-FPNNLRMILTQSPQHKTktrnstIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtsEACAEYVPLAEGGEIKFDGGSVRCVQKSMEfdD
 ||.|. |  . ..  .| || | .||      .. || |  ...   ||     .|  .         |..| || |.  ..|   ||. |.  .|  .
dyinanfvdGykqkkafiatqGplkkt......vsdfWrmvWeqevlvivmttrvvergr.......lkcgqyWpleeessaefgdlsvsnveveee..e

EGEVRQLLVK-FDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN-----------------TTPVIVHCKNGISKSACFAY
. .||.| .|  ... . .. |  . .| |  ||.| . .||.|.||  .                   |..|||  || ..  |. 
dykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfit
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 931-1102 2e-07 25.0 In-house 71-249 (301) alignment 
Range on Protein: 931-1102
Range on HMM: 71-249/301.0
GYIHASKV-IFPNNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHNldwdtseACAEYVPLAEGGEIKFDGGSVRCVQKSmeFDD
 || || .  . .. . | .|.| .|      |.  || . .||.  ||| ...  | |..        | .| | .|  . .|   .|  |..      
eyinasyidgysekkkfiaaqgpmkk......tlvdfWrliwqekpvsivmvtnlkegtks.......kceqywpnseaeseefgpftvtlvneq..vyP

EGEVRQLLVKFDDQ----------------PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVN-----TNTTPVIVHCKNGISKSACFAYIELA
.  .||| ||  |                    ..  |    | .  |   |. .|  .|.|       .  ||.||| ...|.|  .  ....
dfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsig
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 932-1102 1.3e-15 52.4 In-house 76-239 (305) alignment 
Range on Protein: 932-1102
Range on HMM: 76-239/305.0
YIHASKVI-FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRcVQKSMEFDDE
|| || |  . .. . |..|.|       ..|.. || . ..|. ..||.|.. .|       .  . |  | | ... . .|.  ||  .. . .. | 
yinasyvdgykrkkkyivaqgPl......kntvadfWrliveekvstivmltklve.......ggkdkCrqYWpesktekkefgefsve.lksektasdy

gEVRQLLVKF--DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN-----TTPVIVHCKNGISKSACFAYIELA
   |.| . .  .|. . |. ..    | |  ||...  .|.|...|. .      .|..||| .|....  |  ...|
.ieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia
subfamily_Ptp69D_pd Subfamily Ptp69D 932-1104 1.8e-15 51.9 In-house 78-244 (307) alignment 
Range on Protein: 932-1104
Range on HMM: 78-244/307.0
YIHASKVI-FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldWdTSEACAEYVPLAegGEIKFDGGSVRCVQKSMEfdDE
|| || .. . .. . |  | |       ..||. || | ..  .. || | .  |      . . . || | |     |....   |..|...    ..
YinasfikgykekkkfiaaqdPv......eatigDfWRmiaeqevtlivmlsnlte......k.nrkkcakYWpie..devqygdilvklvseekh..sd

GEVRQLLVKFDD------QPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKV----NTNTTPVIVHCKNGISKSACFAYIELACQ
   |.| |   .      . .  .    | ||||  |||... .|.|...|    ..| .|..|||..| ..|. |  ...  |
yiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllq
0044763 (Phosphotyrosine protein) phosphatases II 932-1138 1.4e-14 49.6 In-house 20-162 (178) alignment 
Range on Protein: 932-1138
Range on HMM: 20-162/178.0
YIHASKVIfPNnlrMILTQSPQhktktrnstiEKFWWMAMQERSKSIVQLCENMEPTHNLdwdtseaCAEYVPLAEGgeikfdggsvrcvqksmefddeg
||.||... |.   ..|.. |.          .... .  ..  ..|| |.|..|. ..        | .| |  .|                       
yinaseil.pg...lylgslpp..........addlellkelgithivnlteelelgflk.......cdpywpeeag.......................

evrqllvkfddqpeftIEHLWYrGWKDRLVPESPKIMLDLLDKVN----TNTTPVIVHCKNGISKSACFAYIELACQMipgltsDQSDRDILYVLLRMRA
                |..|.. .. |  ||......|.... ..    ..  ||.|||. |.. |.... . | ...      . |  ...  . ..| 
................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp

eCFPNYQLYSF
 ..||   . .
.ivpnpgqlrq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 932-1162 8.8e-14 45.9 In-house 69-291 (312) alignment 
Range on Protein: 932-1162
Range on HMM: 69-291/312.0
YIHASKV-IFPNNLRMILTQSPQHKTKTrnstieKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEgGEIKFDGGSV--------RCVQ
||||  | |  .  |.. ||.| ..| |      .|| .|.   | ||. ||  .|       |.|| ||.|.     | ....   |            
yihanfvkictkperfvctqgplentct......hfwqlalslgstsiillcgfve.......dgsekcakyisdiv.gfvdledhrvyteycteieigg

KSMEFdDEGEVRQLLVKFDDQpEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIElacQMIPGLT--SDQSDRDILY
|| .      | ...||   | |  ..|  .  | |  .|.|    | ||  |. .  ||| ||  |. ..  .| ||    ||  |     |  .|.. 
kskdk.ithrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlalie...smiaalrhprkqnvkdsfv

VLLRMRAECFPNYQLYSFALYGVFMRLMEVGFFEEASKKKPR
.| . ||     .  | .||  |.  |.  |...   ..  .
llrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 932-1127 6.4e-11 36.7 In-house 59-243 (283) alignment 
Range on Protein: 932-1127
Range on HMM: 59-243/283.0
YIHASKVI----FPNNLRMILTQSPQHKTKtrnstiEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPlaEGGEIKFDGGSVrCVQKSMEf
|| |. ..      .. . | .||| ..|.        || |  .|.  .|| | . .|       |  ..|. | |  . | ...    |  ..| .  
yinavfipvsksykqdkkyiiaqsPldrtv......vdfWkmvfdekitaivmltklqe.......dlrikCsqyWP..krGsedyGeftv.tlrkett.

DDEGEVRQLLVKFD--DQPEFTIEHLWYRGWkDRLVPESPKIMLDLLDKVNTN-----TTPVIVHCKNGISKSACFayIELACQMIPGLTSdqSDRDILY
 .   ...||.. .   . .. . |  . .|     ....   |  ..|| ..      .|..||| .|| ..| |  | ... .   ||.  |  |.  
snsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf..iaasasvkdalte..svvdvfa

VLLRMRA
|.  || 
vvkimre
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 932-1100 7.2e-11 36.5 In-house 74-231 (315) alignment 
Range on Protein: 932-1100
Range on HMM: 74-231/315.0
YIHASKVI-FPNNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPthnldwDtSEACAEYVPLAEGGEIKFdgGSVRCVQKSMEFDDE
|| ||..  . ..   | .| |.      ..... || | .||.  .|| . .  |       |    |. | |  ..  ..|  ||..    |.| | .
yinasyiksvdddkayiasqgPl......kasvddfwrmvlqekvttivmvtkkqeg......d.kikcrqywPdrkadsvef..Gsikvellsleadtd

GEVRQLlVKFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVN----TNTTPVIVHCKNGISKSACFAYIE
| .|.| |  . .   |.    ...| |. |..    .| |. .|     ... ...|||  |. ..  .  |.
gvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 933-1100 2.8e-19 64.0 In-house 78-235 (301) alignment 
Range on Protein: 933-1100
Range on HMM: 78-235/301.0
IHASKVIFP-NNLRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSMEFDDEG
|||  .  . .  |.| ||.|       ..| | || | .|   . || |....|       .. | |.||.|.  . ... .  ... ..| . .... 
ihanwiptsGhphrfiatqgPl......kntsedfwamlvqydvekivmlgqkve.......kleekceeylpvkisekldigrfkikiknkelilnkki

EVRQLLVKfDDQ---PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIE
  |.| |. |     .  |. |  |  | || ||.|   . ||.. |     |..||| .|| .| .|   |
skrtleve.dstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigte
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 933-1100 8.2e-16 53.1 In-house 92-244 (298) alignment 
Range on Protein: 933-1100
Range on HMM: 92-244/298.0
IHASKVIFpnnlRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLcENMEPTHnldwdtSEACAEYVPlaEGGEIKFDGGSVRCVQKSmEFDDEgE
.|| |         |.|| | ..      |.| || | ..| ...|| | .|.| ..         . .| |  . |. ...  .|.  .|  || |  .
lhaykgrn....afiatqaPlte......tvedFWrmvteedigtiVml.tnleeld......ktkyhkywP..degketygeitvsllske.efadl.i

VRQLLV-KFDDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNT-----TPVIVHCKNGISKSACFAYIE
||.| | | . . | .. .| .  | |. |||  . .||||.||....     .||||.| .|. .|  |  |.
vrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid
0046846 (Phosphotyrosine protein) phosphatases II 933-1135 5.4e-14 47.8 In-house 15-161 (176) alignment 
Range on Protein: 933-1135
Range on HMM: 15-161/176.0
IHASKVIFPnnlRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPTHNLdwdtseaCA----------Eyvplaeggeikfdggsvrcvq
|.|. .. .   | | || |       ..|...|. |  ... . .| |.| .|  .         |.                                
inanlilgs...rpiatqgpl......prtladflemlkelgitavvnlteevelgrlk.......cpnywpeleklgi.....................

ksmefddegevrqllvkfddqpeftieHLWYRGWKDRLVPESpKIMLDLLDKVNTNT---TPVIVHCKNGISKSACFAYIELACQmipglTSDQSDRDIL
                           . .. .| |  ||.. ...|.||. ...      ||.|||. ||. ..... . | .        . |  ..|
...........................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveeal

YVLLRMRA-ECFPNYQL
. . ..|   .... . 
alvreqRplgavqtpeQ
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 940-1126 3.1e-10 34.5 In-house 82-254 (287) alignment 
Range on Protein: 940-1126
Range on HMM: 82-254/287.0
FPNNLRMILTQSPQHKTktrnstIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGgeIKFDGGSVRCVQKSmeFDDEGEVRQLLVK
. .. . |...||  .|      . .|| .  ... . || ||...|       .. |.| .| |  .   . .   ... ...     ..  .|.| ||
ykekkafiiaesPmfnt......arnfWkliddrnvtaivmlcqeke.......ndeevcyqyWpeeks..vvlGeyniellnee..vnagyierklevk

FDD--QPEFTIEHLWYRGWKDRL-VPESPKIMLDLLDKVNTN----TTPVIVHCKNGISKSACFAYIELACQMipglTSDQSDRDILYVLLRMR
 ..  ... ...   .  |...  |.|   |.| . ... |.     |...||| ... .|| |  .. . .     .  .   |.. || ..|
nknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink....ckteGviDvfqvlksqr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 942-1128 1.3e-17 58.9 In-house 50-220 (250) alignment 
Range on Protein: 942-1128
Range on HMM: 50-220/250.0
NNLRMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLcenmeptHNLDWDTSEaCAEYVPLAEGgEiKFdgGSVRCVQKSMEFDDEGEVRQLL-VKF
..   | ||.| ..      |||.|| | ..| |..|| |        ||     . . .| |  .  | |.  |.|.   .| |   . ..|.|   | 
erkafiatqgPlqa......tiedfWrmvleeksgtivmL.......tnLkesekt.yhqywPveka.e.ky..Gdvtvsllskeefadytkrklklska

DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN-----TTPVIVHCKNGISKSACFAYIElacQMIPGLTSDQSdRDILYVLLRMRAE
  . | .. .| .  | |. |||  . .|.||.||...     ..||||.| .|...| .|  |.    ..  |  ..   |.  |. ..|..
kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid...avlerlkkekv.vdvfkvikvlrkd
0043147 (Phosphotyrosine protein) phosphatases II 944-1141 5.4e-17 57.5 In-house 20-155 (172) alignment 
Range on Protein: 944-1141
Range on HMM: 20-155/172.0
LRMILTQSPqhktktRNSTIEKFWWMAMQERSKSIVQLCENmepthnldwdtseacaeyvplaeggeikfdggsvrcvqksmefddegevrqllVKFDDQ
 | | || |       ..|...|| |  ..  . || |.|                                                      ..  ..
drfiatqgp......lrntladfwrmlkelgithivnltel.....................................................lydpel

PEFTIEHLWYRGWKDRLVPeSPKIMLDLLDKVNT-----NTTPVIVHCKNGISKSACFAYIELACqmipgltSDQSDRDILYVLLRMRAECFPNYQLYSF
 | .. ...| .| |  || .....|..|. ...     .  ||.|||. |.. ..... . | .        . |  ...  . ..|  ...| . | |
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqyrf

ALY
 .|
lyy
subfamily_PTPRG_pd Subfamily PTPRG 944-1100 1.6e-08 28.3 In-house 91-241 (563) alignment 
Range on Protein: 944-1100
Range on HMM: 91-241/563.0
LRMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCenmepthNLDWDTSEACAEYVPLaeGGEIKFDGGSVRCVQKsmEFDDEGEVRQLLV-----
   | || |       ..|.. || |  ..... || .        ||  .. . |  | |    . ....  .|. ...  |      ||.| .     
kafiatqgpl......kdtfddFWrmiWeqnvaiivmit.......nlvergrrkcdvYWPk..desetygalqvtliee..evlalytvrtlviknlkl

KFDD--QPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT----NTTPVIVHCKNGISKSACFAYIE
|  .  . | .. .  |  | |  |||..   |    | ..    .. |..|||..|....  .  ..
kkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld
subfamily_PTPN3_pd Subfamily PTPN3 945-1138 2.1e-18 61.3 In-house 85-266 (280) alignment 
Range on Protein: 945-1138
Range on HMM: 85-266/280.0
RMILTQSPQHKtktrnsTIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtsEACAEYVPLaEGGEIKFDGGSVRCVQKsmEFDDEGEVRQLLVKFDD-Q
| | || | .|      | ..|| |  ...|. || | ...|  .         | .| |  .. |... . ||.| ..  . . .  .|.|..|  . .
ryiatqGPlak......tatdfWqmvweqksslivmlttlverGr.......vkChqyWPe.tedeleygefsvkceke..detksyvlrelvlkdketk

PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN----TTPVIVHCKNGISKSACFAYIELACQMIPGlTSDQSDRDILYVLLRMRAECFPNYQLYSF
 | .| .| |  | |  ||.... .|.....|..     ..||.|||  || ..  .  .|.| ..|   . .    ||.  .   ||   .. . | |
eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea.aepvypldivrtmrdqramlvqtasqykf
0036282 (Phosphotyrosine protein) phosphatases II 945-1139 3.5e-16 54.9 In-house 18-162 (174) alignment 
Range on Protein: 945-1139
Range on HMM: 18-162/174.0
RMILTQSPQHktktrnstiekFWWMAMQERSKSIVQLCENMEPTHNLDWDTSEAcaeyvplaeggeikfdggsvrcvqksmefddegevrqllvkFDDQP
| |..| |             || |  .......|.|.| .|. . . ..                                             . . .
rliagqgpla...........fwemlkelgittvvmlleekelglykcinywpe.........................................lredl

EFTIEHLWYRGWKDRLVPESPKiMLDLLDKVNTN-----TTPVIVHCKNGISKSACFAYIELACQMIPgltsdQSDRDILYVLLRMR---AECFPNYQLY
| .. ...| .| |. ||.... .|.... |..        ||.|||. |.. ..... . | ....      .| .|.|... ..|     .... . |
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.....eslvdaldlvrelRlqrpgmvqtpsQy

SFA
 | 
rfl
subfamily_PTPRK_pd Subfamily PTPRK 945-1106 5.2e-13 43.5 In-house 87-237 (314) alignment 
Range on Protein: 945-1106
Range on HMM: 87-237/314.0
RMILTQSPQHktktrnSTIEKFWWMAMQERSKSIVQLCENmepTHNLDWdtseACAEYVPlaEGGEIkFDGGSVRCVQksMEFDDEGEVRQLLVKF---D
  | || | .      .|.. || .  .|.. ||| | |    ...  .     | .| |  | .|. ..   | .|.  .| . |  || . |.     
afivtqgPlq......etvkdfWrlvydencasivmltel...vevgrv....kClkyWP..edtev.ygdikvelve..tellaelvvrifrveklarg

DQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNT----TPVIVHCKNGISKSACFAYIELACQMI
 .   .. .. . || |  || | . .|.|. .|.. .     ...||| .|  .. .|  |.  ..||
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 945-1099 7.2e-08 26.7 In-house 93-232 (315) alignment 
Range on Protein: 945-1099
Range on HMM: 93-232/315.0
RMILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAeggEIKFdgGSVRCVQKSMEFDDEGEVRQLLVKFDDQP
| | .|.|.       .... || . ..|    || | . .|       .  . . .| |     .. .  | .   .|| |  .|  || | | |.|. 
ryiaaqgpn......vasvkdfwrlvfeedigkivmltnlve.......gekrkaekywpdk...kviy..Gkitvtrkseevnteytvrtlsvvfgdni

EfTIEHLWYRGWKDRLVPESPKIMLDLLDKVN----TNTTPVIVHCKNGISKSACFAYI
. ..  | |  | |  ||..   ...|  .|.    .. ....|||..|. ..  |  .
r.evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 946-1129 5.4e-19 63.3 In-house 92-258 (288) alignment 
Range on Protein: 946-1129
Range on HMM: 92-258/288.0
MILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGgEIKFdgGSVRCVQKSMEFDDEGEVRQLLVKfDDQPE
 | ||.|        .|...|| .  ..... || | | .|       .  . | || | |.  . ..  |||  . .. .  ..  .|.||..  .. |
yiatqgPl......adtvndfWelvyenktstivmltelve.......ggktkCeeYWPdadk.pkny..Gsvtvtlveskeledfvlrkllle.kkkte

FTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT----NTTPVIVHCKNGISKSACFAYIELACQMIPGltsdQSDRDILYVLLRMRAEC
..| .. | .| |  |||| . .|.||..|..    .| |.|||| .|. ..  |  .. . ...      .   |.. .. ..| . 
leitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee....edyiDvagtvaklRkqR
subfamily_PTPRA_pd Subfamily PTPRA 946-1106 5e-13 43.6 In-house 103-255 (330) alignment 
Range on Protein: 946-1106
Range on HMM: 103-255/330.0
MILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPlaEGGEIKFdgGSVRCVQKSMEFDDEGEVRQLLVK-----F
 | .| |.      . |.| || |  . .| .|| | |  |          | || | |  . | . .  | .|   . ..   .  ||..||.      
fiaaqGPk......eetvedfwrmiweqksativmltelke.......rkeekcaqywP..deGlvty..Gnirvevedetvlvdytvrkflvqqlpdat

DDQPEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN----TTPVIVHCKNGISKSACFAYIELACQMI
.....  .. . ...| |  ||  |. ||.|| ||..     . |..|||  |. ..  |  ..   ...
rekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlerv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 946-1128 1.1e-10 36.1 In-house 93-266 (325) alignment 
Range on Protein: 946-1128
Range on HMM: 93-266/325.0
MILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQlcenmepTHNLDWdTSEACAEYVPLAEGGEIKFDGGSVRcVQKSMEFDDEgEVRQLLVKFDDQP-
.. .|.|.       .||. .| .... |.  .|        .  ||    . || | |   |   .| |  |. ..   |. |    |.| ||  ..  
flaaqaPl......tatindlWrlvldWrcsvvvv.......lneldl.gkdrcavywpkemgksktfGglevk.lrtieeisdy.vhrvldvkqvkkGe

EFTIEHLWYRGWKDRLVPESPKIMLDLLDK-------VNT---NTTPVIVHCKNGISKSACFAYIELA-CQMIpgltsDQSDRDILYVLLRMRAE
  ... . ...|.|  |.. |  .. .|.        |..    .||..||| .|. ..  |. .  |  ..|     ..|  ||. .. ..|..
trsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvi.....eesrvdifgfvkklrkd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 947-1105 2.2e-07 24.7 In-house 94-238 (439) alignment 
Range on Protein: 947-1105
Range on HMM: 94-238/439.0
ILTQSPQhktktrNSTIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtseacaeYVPLAegGEIKFDGGSVRcVQKSMEFDDEgEVRQLLV--KF-DDQ
| || |.      . | ..|| . .....  ||.|.. .|  .            | |    .|. .   .|| |.. .|. .   .| . |  .    .
iatqgpk......kettddfwrlviekktvtivmltnlvesyk............ywpsd..aevcygdiavr.vdrnielpny.virgfkvfnerdtte

PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNT-----NTTPVIVHCKNGISKSACFAYIELACQM
 | |. .. |  | |. ||     .||.|  .|.     .. ||.|||  |. ..     ...| . 
kertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 953-1115 3.1e-23 77.2 In-house 28-186 (255) alignment 
Range on Protein: 953-1115
Range on HMM: 28-186/255.0
QH--KTKTRNS-TIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQksMEFDDEGEVRQLLVKFD-DQPEFTI
..  | |. .| |..||. . .| ... .| ||.  |       .. | | .| ||   .  |.   .| . .     |     .... ..   .   |.
ekdkkrknlysltvdkfyqtivqtktevvvmlcdfae.......egvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtv

EHLWYRGWKDRLVPESPKIMLDLLdKVNTNTTPVIVHCKNGISKSACFAYIELACQ-MIPGLTS-DQSD
.|  |.|| ..  || .. .| .| || ... .|.||| .|| .|| |. .||. | ||  |   .  .
khysykGWieknaPelareilnil.kvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetve
subfamily_hpo-7_pd Subfamily hpo-7 956-1118 3e-19 63.9 In-house 36-195 (263) alignment 
Range on Protein: 956-1118
Range on HMM: 36-195/263.0
TKTRNS----TIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSMefDDEGEVRQLLVKFD-DQPEFTIEH
 |. .|    ||.||. .  | ... .| ||.  |       .  | | .| ||   .  |.   .| . .     |     ..||  ..  .   |..|
rknlysllvqtidkfyqtivqtktevvvmLcDfne.......egvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkh

LWYRGWKDRLVPESPKIMLDLLdKVNTNTTPVIVHCKNGISKSACFAYIELACQ-MIPGLTS-DQSDRDI
  |.|| ..  || .. .| .| ||..|  ...||| .|| .|| |. .||. | ||  |   .  . | 
ysykgWiekndpelareilnil.kvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldy
subfamily_CG42327_pd Subfamily CG42327 958-1076 5.6e-10 33.4 In-house 80-191 (319) alignment 
Range on Protein: 958-1076
Range on HMM: 80-191/319.0
TRNSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSMEFDDEGEVRQLLVKFDDQPE-FTIEHLWYrGW
. ...  .|| .  . .|. ||||..  |          . ||||.|  |... .   | ..   |  | .|.  .  ||.|  |. |   . | ||  |
sledsssdfwrtvweqqsrvivqltdlse.......lGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kw

KDRLVPESPKIMLDLLDKVN
 .  || ... .. .| .|.
leaevPaeeaaliamllevr
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 960-1127 4.8e-20 66.8 In-house 83-245 (274) alignment 
Range on Protein: 960-1127
Range on HMM: 83-245/274.0
NSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSMEFDDEGEVRQLLVKFDDQpEFTIEHLWYRGWKDR
 .|.. || |  ||... || | .  |          . ||.| | ||. ||.   | |    ...   .. .||.|..|   . | .. | ||  | |.
pntvadfWrmiyqeevqvivmltklke.......aneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdh

LVPESPKIMLDLLDKVNT-------NTTPVIVHCKNGISKSACFAYIELACQMIpgltSDQSDRDILYVLLRMRA
 .|.... .|||...|..       ...||.|||  || .  ||  |..|.. .     ...  |.| .   .| 
ksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrql....reeivvdvlkivcnlrl
subfamily_PTPN6_pd Subfamily PTPN6 960-1107 6.5e-17 56.5 In-house 108-255 (306) alignment 
Range on Protein: 960-1107
Range on HMM: 108-255/306.0
NSTIEKFWWMAMQERSKSIVQLCENMEPTHNldwdtseACAEYVPLAEGGEIkFDGGSVRCVQKsmEFDDEGEVRQLLVK--FDDQPEFTIEHLWYRGWK
..|.. || |..|| |. || . ...| ...        || | | .|  |  .   ||..|..  .  .. ..|.|.|.   ... | .. .. .. | 
ettvsdFWrmvwqensrvivmttkevErgke.......kCarYWPdeeekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWP

DRLVPESPKIMLDLLDKVNTN--------TTPVIVHCKNGISKSACFAYIELACQMIP
|  ||..|. .||.|..||..        . |..||| .|| .   |  |..  ..| 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillklie
subfamily_PTPRD_pd Subfamily PTPRD 960-1104 3.2e-16 54.1 In-house 101-239 (564) alignment 
Range on Protein: 960-1104
Range on HMM: 101-239/564.0
NSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAeGgEIKFDGGSVRCVQKsMEFdDEGEVRQLLVKFDDQPE-FTIEHLWYRGWKD
..||| || | ....|..|| | .  |        . . |..| |   | . ....  |  ...  |.  . |.|.. .|  .. |  ....  .  | |
aetiedFWRmvweqnsstiVmltkleE.......kgkvkchkYWPek.g.tetygeltVtleee.eel.adyeirtfklkkkkssesreVrqFhFtsWPd

RLVPESPKIMLDLLDKVNT----NTTPVIVHCKNGISKSACFAYIELACQ
. ||||.. .|||..||..    .. |..||| .|.  . .|  |.   .
hgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 960-1127 1.5e-15 51.9 In-house 74-244 (270) alignment 
Range on Protein: 960-1127
Range on HMM: 74-244/270.0
NSTIEKFWWMAMQERSKSIvqlceNMepTHNLDWDTSEACAEYVPLAEGGEIKFDGGSVRCVQKSMEFDDEGEVRQLLVKfDDQPEFTIEHLWYRGWKDR
..|...|| | ..|....|      |  | .|  .  . |. | |   . ..|.  | .. .. | | ..   ...| .. ..  |  . | ||  | |.
pttlksfwrmiweekvtai.....vm..ttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdh

LVPESPK------IMLDLLDKV-----NT-NTTPVIVHCKNGISKSACFAYIELACQMIpgltSDQSDRDILYVL---LRMRA
 ||...        .| .| .|     .. ...|..||| .|. .. ..  .. |....    . ..  |.| ..    . | 
gvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlL....eetkkvdvlaiieelRkdRm
0049260 (Phosphotyrosine protein) phosphatases II 960-1140 4.6e-13 44.6 In-house 19-143 (152) alignment 
Range on Protein: 960-1140
Range on HMM: 19-143/152.0
NSTIEKFWWMAMQERSKSIVQLCENMEPTH---NLDWdtseacaeyvplaeggeikfdggsvrcvqksmefddegevrqllvkfddqpeftieHLWYRGW
. |...|| |  .   . || |.| .| ..   .  .                                                        .  .  |
pntladfwrmlkelgittivmltellelgklkceqyi........................................................qylhlpw

KDRLVPESPKIMLDLLDKV----NTNTTPVIVHCKNGISKSACFAYIELACqmipgltSDQSDRDILYVLLRMRAECFPNYQLYSFAL
 |  ||... ..|.||. .      .  ||.|||. |.. ..... . | .        . |  ...  . ..|   .|| . . | .
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 960-1104 4.3e-09 30.9 In-house 99-238 (318) alignment 
Range on Protein: 960-1104
Range on HMM: 99-238/318.0
NSTIEKFWWMAMQERSKSIVQLCENMEPTHnldwdtsEACAEYVPlaEGGEIKFDGGSVRcVQKSMEFDDeGEVRQLLVKFDDQPE-FTIEHLWYRGWKD
  ||| || |  .  |. || | . .| ..       . .. | |  . | ....   |  .....|..|   .|.. |. ... |  ..    |  | |
petieDfWrmvWeqnsavivmltqeeergk.......akvhryWP..skgsrsygklvve.lkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWpd

RLVPESPKIMLDLLDKVNTN-----TTPVIVHCKNGISKSACFAYIELACQ
. ||||.  .|||. .|..      ..|..|||  |. .   |  ..   .
egvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 960-1100 6.9e-07 23.7 In-house 55-193 (237) alignment 
Range on Protein: 960-1100
Range on HMM: 55-193/237.0
NSTIEKFWWMAMQERSKSIVQLCENMEpthnldwDTSEACAEYVPLAEGGeiKFDGGSVRCVQKSMEFDDEgEVRQLLVKFDD-QPEF-TIEHLWYRGWK
.|. . || |  ||.   || |   .|          . | .| | ..    .  |     ..|  || |   || ||.     . |   |    .  | 
esscddfwqmvwqekcsvivmltglie.......gnelkchkywpstdqp..aaygvltvslkkkeefsdy.tvrslllskrltlkevrlihqyqftswp

DRLVPESPKIMLDL----LDKVNT--NTTPVIVHCKNGISKSACFAYIE
|| ||.    .| .    ... .   ...| |.||  |. ... |  |.
drgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid
PTPc_motif_SM00404 1041-1101 6e-06 21.2 In-house 42-102 (140) alignment 
Range on Protein: 1041-1101
Range on HMM: 42-102/140.0
DDQPEFTIEHLWYRG-WKDRLVPESPKiMLDLLDKVNTNTTPVIVHCKNGISKSACFAYIEL
. ...|.| ... .   || |... .| .|| ....... . |.|||. |.| ||...  .|
kensgfqilqiplddnekdklskyldk.vldfienaekkggkvlVHCqaGvSRSatliiaYl
0048076 (Phosphotyrosine protein) phosphatases II 1044-1141 1.8e-12 42.7 In-house 43-137 (145) alignment 
Range on Protein: 1044-1141
Range on HMM: 43-137/145.0
PEFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN---TTPVIVHCKNGISKSACFAYIELACQmipgltSDQSDRDILYVLLRMRAECFPNYQLYSFAL
.| .. ...| .| |. ||......|..|. ...      ||.|||. |.. ..... . |  .       . |  ..|  . ..|  ..|| . . | .
lerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpgqlrfly

Y
.
e
0048179 (Phosphotyrosine protein) phosphatases II 1045-1139 1.1e-11 40.1 In-house 46-137 (144) alignment 
Range on Protein: 1045-1139
Range on HMM: 46-137/144.0
EFTIEHLWYRGWKDRLVPESPKIMLDLLDKVNTN---TTPVIVHCKNGISKSACFAYIELACqmipglTSDQSDRDILYVLLRMRAECFPNYQLYSFA
|... .... .| |. ||......|..|. ...      ||.|||. |.. ..... . |        . . |  ..|. . ..|  ..|| . . | 
eregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnpgqlrfL
PTPc_DSPc_SM00012 1047-1139 2.7e-14 48.6 In-house 1-99 (105) alignment 
Range on Protein: 1047-1139
Range on HMM: 1-99/105.0
TIEHLWYRGWKDRLVPESPKIMLDLLDKVNTNTT------PVIVHCKNGISKSACFAYIELACQMIPGLTSDQSDRDILYVLLRMRAECFPNYQLYSFA
|. |..| ||.|  |||... .|.||..|..|..      ||.|||..|......|. .....|..   |.  .  .|.  | ..|. .. ... |.| 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl