Gene sdf-9 in Caenorhabditis elegans

Synonym: CELE_Y44A6D.4, sdf-9

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily eak
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP179_AA protein Get Run
CeleP179_AA_9-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_eak_pd Subfamily eak 5-312 1.5e-181 597.0 In-house 26-332 (332) alignment
Range on Protein: 5-312
Range on HMM: 26-332/332.0
SIRSNIVHKLDDNQPLLSERVTARLEAVNRNrVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQF
. | |||..|||.|.|||...|||||||||| ||||||..||.||||.|.|||.|||||||.|||.||.|||||||.|||||||||||||||.||.|.|.
nqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivql

ADNVEEKLEHYDKYFPDKG-DVWSYGHLQVERKSYaIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGALNMINPASALF
...||.|||..|||||||. .....|.|.||||.. .......||...|.||||||||||..||||||||.|...||||||||||..|.|..|...|||.
ledvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksall

RSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPLIAYS
.||...||||||||||||||||||.|||.|||||||||.||.||.|||||||||.|.|..|||.|.|||.||||||.|||||||||.|..|.|..|.||.
sstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleaya

ESCFVKWSS
||..||.||
esvrvkdss

subfamily_CG42327_pd Subfamily CG42327 5-177 3e-16 54.0 In-house 2-179 (319) alignment
Range on Protein: 5-177
Range on HMM: 2-179/319.0
SIRSNIVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLME-FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTII
. |.... ...|   |...       . ...||...||    .| |   .  ..| |..|| .  . |    || . .. ||   .||..| ||.| .|.
erredvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrviv

QFADNVEEKLEHYDKYFPDKG---DVWSYGHLQVERKSYAIHQGnFHTRNFILRK-GNETHRVLHFTVFGWTETTTPIM
| .|  |  ..   .|.| |    .  .||...|  |  ....  . .  ..|..  .|  | |    . | |.  |  
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdr.yaistlllkrvdkeesrelthywykwleaevPae

subfamily_egg_pd Subfamily egg 7-284 8.5e-10 32.8 In-house 19-269 (307) alignment
Range on Protein: 7-284
Range on HMM: 19-269/307.0
RSNIVHKLDDNQPLLSErVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAD
| ...... |...|    ...      |.. |.     | ...|   .   | .| |  ..   .  ..||.  |  . |  ||.|| ... . |. .. 
rlevleesvdeisltta.asdnnlekarskrvhckdssrvklelrrGqyldd.fihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlts

NVEEklehydkyfpdkgDVWSYGHLQVERKSYAIHQGNFHTRNFIL-RKGNETHRVLHFTVFGWTetttpimQDFLALRKVMKDTGAL-NMINPASALfR
..|              .   |   . | .|  .  |...  |. . .| .   || .. . |         .. . | .   |   . ..  |   | |
rkes.............erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.......deerflehwqgdvnnssdvysplrvl.r

StmRRYIHTPpsfaPIIQSARGSSRAGAFVVIDL-LIRMIDGkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDY
    | . .|     ..|.  | |.|...| |.. |. .. |  .  . |   .|  .  |   |  .| . |.|  || .
k..lrnlskp....vvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlff

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 8-290 7.1e-26 85.8 In-house 22-282 (315) alignment
Range on Protein: 8-290
Range on HMM: 22-282/315.0
SNIVHKLDDNqPLLSERVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAD
|. .| | |  .   .||.   .  ..||   |.| ..  |.|        . ||||| ..  |  . || .  | .  |  ||.|||...  ||.  ..
seefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

NVEEKLEHYDKYFPD-KGDVWSYGHLQVERKSYAIhQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDflALRKVMKDTGAlnminpasalfrs
  |.   .  .|.|| |.|   .| ..||  |    ...  .|....||..|...|  |   .| .  ..  .   .| |..|.  |             
kqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevka.............

tmrRyiHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
      . .  |. ..  . |  |.| .. ||  .  |  |.|.   | ... . .  |.. |    ...|||.|||..|| || 
...d..ngkkefsllvhcsaGvGrtGvvisidevvaqi..krtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

subfamily_PTPN1_pd Subfamily PTPN1 9-283 5.2e-22 72.9 In-house 10-269 (290) alignment
Range on Protein: 9-283
Range on HMM: 10-269/290.0
NIVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLnrdGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNV
.|.......   .. |.. . |  |.||   . | .   ..|  .      ||||||.|. .. ..||||  |  . |  ||||| ||.| ... .   |
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EEKLEHYDKYFPDKGD--VWSYG--HLQVERKSYAIHQgNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGALNminpasa
|..     .|.| . .     .   .|.|.  |  ... ..  | . | .   .||. .|||    |.. . |   . || .   ....|.|.       
ekeqikcaqywPqgeeekellledtklkvkliseerks.yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.......

lfRStmrryiHTPpsfaPIIQSARGSSRAGAFVVIDLLIRMIDGKK-TNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
  .       . |    ..|  . |  |.|.|...| ..  |. |. ..   ... ... ...|.  .  |    | | |.|.
..sd......vGp....avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

0036941 (Phosphotyrosine protein) phosphatases II 10-300 3.2e-50 166.5 In-house 18-292 (297) alignment
Range on Protein: 10-300
Range on HMM: 18-292/297.0
IVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPsmlNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
  ..|.....| | .|....| ...||   |.|  .  |.|..   . ..|||||.... |...|.|.|  | .. |  ||.||.||....|. . . ||
efeellpllllgslsvallpenleknRykdilpydhtRVkldd...egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve

EKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIH-QGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNminpasalfr
   | ...|.|.. |... ||...|. .|. ..  .....|.. . .  ..|...| || ..|| .  .|  ....|.. . ...  .|           
lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll..........

stmrryihtPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGK-KTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPLI
         |..   .. .  | .|.|.|...||.......| |.. ... ... | ...| ..|.   .  |.|||.|..|..........|. |.
.........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll

0040438 (Phosphotyrosine protein) phosphatases II 11-320 6.4e-49 162.3 In-house 24-310 (317) alignment
Range on Protein: 11-320
Range on HMM: 24-310/317.0
VHKLDDNQPLlSERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
 ..|.....  . .|....|  ..|| . |.|  .  |.|.| .  . ..|||||.... . ..|.|.|. | .. |. ||.|| ||.. .|. . . .|
fedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtelee

EKLEHYDKYFPDkGDVWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGalnminpasalfrst
 . | ...|.|. |... ||...|. .|.    .... |.. .   ...|...| ||   ||.. ..|  ....|.. . ...                 
lgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal...............

mrryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPlIAYSESC
       .|.   .. .  | .|.|.|....|.....  .|.. ..||. . . ...| ..|.   .  |.|.|.|.||.|....  . . .  .. . .
......edpggpvlVHCsaGvgRtGtfiaaylmleql..ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselk.lkllkll

FVKWSSMDKEIEKF
 ... ...|..|| 
iplalddvklkeke

0050432 (Phosphotyrosine protein) phosphatases II 12-288 1.4e-44 148.0 In-house 49-302 (308) alignment
Range on Protein: 12-288
Range on HMM: 49-302/308.0
HKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLtpSmlNRDGYINASLMEFS--DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
..| ...|||. .|... | ...|| . |.|  .  |.|  .  . ..|||||.. .   .. .|.|.|  | .. |  ||.|| ||....|. . . ||
eellsvkplleysvallpenkdkNrykdilpydhsRVkl..d..egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve

EKLEHYDKYFPDK--GDVWSYGHLQVERKSYAIhQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGalnmiNPasalfr
 . | ...|.|..  |... ||...|. .|. . .... .|...|..  ..|...| ||   .| .  .|  ....|.. . ....      ..      
ngrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pg......

stmrryihtppsFAPIIQSARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
               .. .  | .|.|.|...|||..... .  .  .|.... | ...| ..|.   .. |.|.|.|.||...
............gpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_PTPN13_pd Subfamily PTPN13 12-285 8e-17 56.4 In-house 18-269 (273) alignment
Range on Protein: 12-285
Range on HMM: 18-269/273.0
HKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSmlnrDGYINASLMEFS--DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
..| . .||.. .|. . |  ..||  ...|  .  |.|  .     |||||||..    .   .||..  |  . |  ||||| ||..  |.  . ..|
kelrelkpldtcevgkkkenkdknryrnvlPydetrvklgde....ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

EKLEHYDKYFPDKG--DVWSYGHLQVERKSYAiHQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPimqdflalrkvmkdTGALNMINpasalFRS
..    ..|.|..    .  .. |.||   .  .. .|  |.. ...   .|...| |.    | .  .|              . |.....     | .
kgkvkchrywPesknkklkvsnrlevellkvq.kldgfvvralavkdsesgesrevahlnfvkwPdhgvP..............ssaaellq.....fva

TMRRyIHTppSFAPII-QSARGSSRAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
 .|| ..|  . .||.   . |  |.|....|| .. .|. .|   . |.... | .. |   |     . |.|.|.|. |
evrr.lqt..dagPivvhcsaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 12-290 5.1e-16 53.1 In-house 27-241 (392) alignment
Range on Protein: 12-290
Range on HMM: 27-241/392.0
HKLDDnQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEE
| | .  ..  ..|. .   ...||  .|.| ..  |.|      . . |.||| ..  |  . || .  |    .  ||.||....  ||.  ..  | 
hdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkeg

KlehydkyfpdkgdvwsyghlqverksyaihqgnfhtrnfilrKGNETHRVLHFTVFGWTETTTPIMQDflALRKVMKDtgalnminpASALFRStmrrY
                                           ||.... |  | .  | .   |      .| |..|.          .| | .    |
d..........................................kgddartvaqfhftewPdkdvpkhts..sllkfike.........vkadfGq....y

IHtpPsfaPIIQSARGSSRAGAFVVIDLLIrmIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
 |  |    ||. . |  |.|  . || ..     ||| .  | ..... .. | . | .  ...||| |||. || || 
th..p...liihcsagvgrtgvvisidsvv..ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrnt

DSPc_SM00195 13-285 3.4e-49 162.9 In-house 8-262 (263) alignment
Range on Protein: 13-285
Range on HMM: 8-262/263.0
KLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
||.....  . . ... . ...||  .|.| ..  |.|...   . . ||||. .....  .|||.|  | .. |  ||.||.|.....|. . ...|..
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

LEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstm
 |. |.|.|.. |. . .|...|. ... ... ....|.. |.| .  ||..| .. . .|..  .|  ....|.| ...| .   .             
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.............

rryihtppSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
        |   ....  | .|.|.||.||.... .. .|.  ....... . .. |...|    ...|||||.|.|.
........sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 13-285 3.4e-49 162.9 In-house 8-262 (263) alignment
Range on Protein: 13-285
Range on HMM: 8-262/263.0
KLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
||.....  . . ... . ...||  .|.| ..  |.|...   . . ||||. .....  .|||.|  | .. |  ||.||.|.....|. . ...|..
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

LEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstm
 |. |.|.|.. |. . .|...|. ... ... ....|.. |.| .  ||..| .. . .|..  .|  ....|.| ...| .   .             
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.............

rryihtppSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
        |   ....  | .|.|.||.||.... .. .|.  ....... . .. |...|    ...|||||.|.|.
........sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0043336 (Phosphotyrosine protein) phosphatases II 13-285 5.4e-42 139.5 In-house 28-277 (278) alignment
Range on Protein: 13-285
Range on HMM: 28-277/278.0
KLDDNQPlLSERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
.|.....  . ......| ...|| . |.|  .  |.|.. .  . ..|||||.... .|..|.|.|. |... |  ||.|| |....||.   . || .
ellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelg

LEHYDKYFPdkGDVWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGalnminpasalfrstmr
 . ...|.|  |... ||...|. ...   ......|.. .   . .|.. |.|.  .|| . ..|  ....| . |....                   
rvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal.................

ryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
     ... . .. .  | .|.|.|....||....  .|.  ...|. . . ...| ..|.   .  |.|||.|.||
....edsngpvlVHCsaGvgRTGtfialyllleql..ekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_Ptp69D_pd Subfamily Ptp69D 13-286 5.5e-26 86.4 In-house 30-287 (307) alignment
Range on Protein: 13-286
Range on HMM: 30-287/307.0
KLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
||  ..  .| .|... |   .||  .|..  .. |.|..  . .   ||||| ..  .  .|.|    | |  .. ||.|. || . .|.  ..  | .
kLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltekn

LEHYDKYFPDKgDVWSYGHLQVERKSYAIHQgNFHTRNFILRKGN-------ETHRVLHFTVFGWTETTTPIMQDflALRKVMKDTGALNMINpasalfr
 .. .||.|.  |   ||.. |.  |   |. ..  |.. . | .       ....|. .   || ... | .    .| |...    |.  |       
rkkcakYWpie.devqygdilvklvseekhs.dyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar..gllklieqvrelykln.......

stmrryihtppsFAPI-IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
             .|| .    |..|.| || .|.|.  .  |. .  .. . . . .. |   |     ..|.| |.|||  
............rsPivvhCsaGvgrsgifvaldsllqql..kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

0051299 (Phosphotyrosine protein) phosphatases II 14-285 1.3e-45 151.5 In-house 32-286 (288) alignment
Range on Protein: 14-285
Range on HMM: 32-286/288.0
LDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKL
| ...| |. ..... | ...|| . |.|  .  |.|..    . ..|||||.... . ..|.|.|  | .. |  ||.|| ||....|. . . || . 
llsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgr

EHYDKYFPDkGDVWSYGHLQVERKSYAIhQGNFHTRNFILR------KGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGAlnminpasalfrs
| ...|.|. |... ||...|. .|. . .... .|.....      ...|...| || ...| .  .|  ....|.. . ...  |             
ekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.............

tmrryihtPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
        ...   .. .  | .|.|.|...|||..... .  .  .|.... . ...| ..|.   .  |.|||.|.||
........sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 14-285 4.6e-43 143.0 In-house 21-272 (273) alignment
Range on Protein: 14-285
Range on HMM: 21-272/273.0
LDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLtpsMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLE
| ...|||. .|... |  ..||   |.|  .  |.|     . ..|||||.... ....|.|.|  | .. |  ||.|| ||....|.   . || . |
llslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgre

HYDKYFPDKGD--VWSYGHLQVERKSYAIhQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGAlnminpasalfrstmr
 ...|.|..|.  .. ||...|. .|. .  ... .|...|..   .|.. | || ..|| .  .|  ....| . ...... .                
kcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale................

ryiHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
   ..| .   .. .  | .|.|.|...|||....  .|..  .|.... . . .| ..|.   .  |.|||.|.||
...alpsngpvvVHCsaGvgRtgtfialdllldql..ekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 14-123 6.4e-10 33.3 In-house 30-154 (350) alignment
Range on Protein: 14-123
Range on HMM: 30-154/350.0
LDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPS---------MLNRDGYINASLMEFS------DVGQKYILTGIPSEDKVFAFWQMVLEQRS
 |.. |     ..  .|.  .|| . |.|  .  |.|  |          |. . ||||. .. .      . . ||| |  |    |  |....|.   
sdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkv

PTIIQFADNVEEKLEHYDKYFPDKG
. |.  ...||  || ...|... .
kvilsltsdvelnlekcyrYWqegs

subfamily_PTPN6_pd Subfamily PTPN6 15-289 4.9e-27 89.7 In-house 38-301 (306) alignment
Range on Protein: 15-289
Range on HMM: 38-301/306.0
DDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLME--FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKL
.... ||| . .|. |  ..||   |.|     | |. . .  . ||||. ..  . .  ..|| |    |. |  ||.||... |  |.    .||   
eeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk

EHYDKYFPDKGDVWSYGHLQVERKSYaIHQGNFHTRNFILR---KGNETHRVLHFTVFGWTETTTPIMQDFL--ALRKVMKDTGALNminpasalfrstm
|.  .|.||. .  .||...|.  |   .. ..  |.. .    |..|...| ..    | .  .|  .. .   |..| . .  |.             
ekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele.............

rryiHTpPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNL-YSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
    ..  . . ..  . |  | |.|.|||.|...|  |...  . ...|. . .. |   | ..  . |.|.|.  |. ...
....ea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

0045450 (Phosphotyrosine protein) phosphatases II 20-287 7.6e-43 142.8 In-house 44-306 (307) alignment
Range on Protein: 20-287
Range on HMM: 44-306/307.0
LLSERVTARLEAVNRNRVVKIVPQHRYNVRLTP--SMLNRDGYINASLM--------EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
| . ......|  ..|| . |.|  .  |.|..  ..|. ..||||| .        .. |...|.|.|  | .. |  ||.|. ||.. .|.   . ||
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

EKLEHYDKYFPDKGDVWSYGHLQVERKSYAIhQGNFHTRNFILR---KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALnminpasalfrs
 . | ...|.||.|... ||...|. .|. . ..... |.. .    . .|...| ||   || ....|  ....|.. . ...  .             
lgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee............

tmrryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNL-YSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
       .|..   .. .  | .|.|.|....|..|...  .| | ..... . . . .| ..|.   .  |.|||.|..||.
.......lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk

0046845 (Phosphotyrosine protein) phosphatases II 22-289 1.4e-45 151.2 In-house 19-278 (284) alignment
Range on Protein: 22-289
Range on HMM: 19-278/284.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFS-----DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEH
| .|....| ...|| . |.|  .  |.|..     . ..|||||....      .. .|.|.|  | .. |  ||.||.||....|. . . || . | 
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

YDKYFPDKGDVWSYGHLQVERKSYAIhQGNFHTRNFILRK---GNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALnminpasalfrstmrry
...|.|..|.|. ||...|. .|. . .... .|.. |..   ..|...| || ...| .  .|  ..|.|.. . ...                     
caqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.................

ihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKK-TNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
  .|..   .. .  | .|.|.|...|||..... .. .  ..|.... . . .| ..|    .  |.|||.|.||....
..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

0039614 (Phosphotyrosine protein) phosphatases II 22-289 2.5e-43 144.0 In-house 47-293 (297) alignment
Range on Protein: 22-289
Range on HMM: 47-293/297.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFSDV-GQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLeHYDKY
. ..... | ...|| . |.|  .  |.|.| .   . . |||||.... |. ..|.|.|. |... |  ||.|| ||....|.   . || .  ....|
dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqy

FPDKGDvwSYGHLQVERKSYAIhQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstmrryihtPPSF
.|..|.   ||...|. ...    .....|.. .....|.. | || ..|| . ..| .....| . . ...  | .                   |.. 
wpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael...................pkgg

APIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
  .. .  | .|.|.|....|.....  .|.  ..|.. . . . .| ..|.   .  |.|.|.|..|.|..
pvlVHCsaGvgRtGtfiaaylmleql..ekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 22-286 7e-29 96.0 In-house 47-291 (298) alignment
Range on Protein: 22-286
Range on HMM: 47-291/298.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
. .|. . |  ..||  .|..     |.|.    .    ||||| ..  .  . .|.|  | .  |  ||.|| |. . ||. . . .| .  .| ||.|
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

DKGDVwSYGHLQVERKSYAiHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIMQdflalrkvmkdTGALNminpasalFRSTMRRYIHTPPSFA
|.|    ||...|. .|   ..... .|.... |   .....| .. .. |.. ..| ..           |  |.        ... .|.. .     .
degke.tygeitvsllske.efadlivrklkvskkkeekerevrqlhftsWpdkgvpena...........tsvld........llrkvrasqqqagnkp

PIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
 |.| . |  |.|.|..|| ..  .  || .   | . .   .. |.. |    . .|||||||..| 
vivqCsaGvgRsGtfiaidsvlerv..kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_PTPN12_pd Subfamily PTPN12 22-286 2.3e-20 67.7 In-house 31-278 (290) alignment
Range on Protein: 22-286
Range on HMM: 31-278/290.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
|  .. . | |..||   |.|     | |.    .  ..||||.... ..  ..|| .  |  . .  ||.|. |..   ..    .|| .  . ..|.|
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DKGDVWS-YGHLQVERKSYAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDFLalrkvmkdtgaLNMINpasaLFRSTMRryihtPPSFAP
..|.    .|...|. ..    . .|  | . ... .|...|  |    | .  .|  .. |           |..|.    |.|.. .       .   
eegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksl...........lelie....lvrelqe.....sedaPl

IIQSARGSSRAGAFVVIDLLIRMIDGKKT-NLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
..  . |  |.|. ..||.  ...  .|. . ..| ||... .. |   |     ....|.||.... 
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 22-173 1.1e-16 55.6 In-house 37-192 (290) alignment
Range on Protein: 22-173
Range on HMM: 37-192/290.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRD---GYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKY
.  |    .  ..||  .||..  . . | |   ..|    ||||. ..     ..||.|  | .. .  ||... ..... |.   . .||. ..  .|
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

FPDKgDVWSYGHLQVERKSYAIHQgNFHTRNFILRKGNE---THRVLHFTVFGWTETT
.||. |. .||. ...  .  ... .. .|.. ... |.   .. | .. .  | .| 
Wpds.dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstg

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 22-135 8.2e-08 26.1 In-house 43-156 (310) alignment
Range on Protein: 22-135
Range on HMM: 43-156/310.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD
|    |  . . .||   .| .    |.|.      . || |  .    . . .| .  | .  .  ||.|....|. .|. .   .||   .   |.| 
sltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps

KGDVWSYGHLQVER
 |   .|| ..|  
lgvtetygcirvtn

subfamily_PTPRN_pd Subfamily PTPRN 23-183 1.7e-18 61.3 In-house 48-212 (297) alignment
Range on Protein: 23-183
Range on HMM: 48-212/297.0
ERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVG-QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
. |. . ..|..||. ...|     |.|.  .  ... ||||| .  .|     || |  |  ..| .||||| || .  |....   || ... ..|.|
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

DKGDVwSYGHLQVERKSYAIHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIMQ-DFLAL
|.|    |.  .|.  |  |   ..  | | |.  . .||  |  |  . |.|...|     .| .
deGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 23-288 8.8e-12 39.8 In-house 40-291 (325) alignment
Range on Protein: 23-288
Range on HMM: 40-291/325.0
ERVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIqFADNVEEKLEHYDKYFPD
 .|... | ...||   .|. ..  | | |        ||||| ..     . .. .  |  . .  .|..||. |.. ..   . .... ..  .|.|.
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpk

K-GDVWSYGHLQVERKSYAIHqGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIMQDFLAlrKVmkdtgaLNMINPASALFRStmrryiHTPPSFA
. |.   .| |.|. ..      ..  | . ..  |. ||  |  | . .| .  ..     |.   .      |....  |   ..       |  |  
emgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli..si......lqlvkavservta......ntkastp

PIIQSARGSSRAGAFVVID-LLIRMIDGKKTNLYSvedLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
 ..  . |  |.|.|. .  .| ..|.  . ...     . | .. |   |  .  ...||||. ....  
ilvhcsaGvGrtGvfislysalakvieesrvdifg...fvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_PTPN3_pd Subfamily PTPN3 24-283 1.6e-24 81.3 In-house 34-273 (280) alignment
Range on Protein: 24-283
Range on HMM: 34-273/280.0
RVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLnrdGYINASLMEFSDVG----QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYF
 .. . | ...||   |.|     |.|. |      ||||. ...   .    ..|| |  | .. .  ||||| ||.| .|. ....||.      .|.
saarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDKGDVWSYGHLQVERKSYaIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGalnminpasalfrstmrryihtPPS
|...| ..||...|. ..   .. .. .|...|.. .  | ...|..    |.. . |   .||| . . ....                         .
Petedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......................sgk

FA-PIIQSARGSSRAGAFVVIDLLIRMIDGKKtNLYSVeDLIVKCKHMRIHCVPVALHHSFIYEAVLD
    ..  . |  |.| ...... . .|. .. ..| . |.. . .  |   |. |  . |. ||.| 
eePvvvhCsaGigrtGvlilletalalieaae.pvypl.divrtmrdqramlvqtasqykfvCeailk

subfamily_CG7180_pd Subfamily CG7180 24-287 4.7e-21 69.7 In-house 35-292 (296) alignment
Range on Protein: 24-287
Range on HMM: 35-292/296.0
RVTARLEAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLeHYDKYFPDK
.   |.|  ..|| ||.||     | |.     ... ||||. ..     ..|| |  | .. | .||..| .. . ...  ... . .   | .|.| |
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GdVWSYGHLQVERKSYAIHqGNFHTRNFILRKGnethrvlhftVFGWTETTTPIMQDFLALRKVMKDTGALNMINPAS--AL--FRSTMRRYIHTP---P
.    ||.. ||  ..     |...|.| | |           .   ||.....  .   ....   .  |.   | |  ||  .|  .| ...     |
s.keqygeifveiveekqy.anlkirtfkltkk..........ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedp

SFAPI-IQSARGSSRAGAFVVIDLLIRMIDgkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  .|. . |  |.||.|... ||  . ...  |..   | . . . .. | . |    .  .||. .|...| 
eegPvvvvssdGasRsGvylaidanlelve..keeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 24-284 4.8e-21 70.0 In-house 42-278 (315) alignment
Range on Protein: 24-284
Range on HMM: 42-278/315.0
RVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK
.|. . | ...|| ..|..  .  |.|      .   |.||....  .  ..|| .  |    |  ||..| |.   .|. ... ||.. .. .||.|||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

gdVWSYGHLQVERKSYAiHQGNFHTRNFILRKGNETHRVLHFTVFGWTETttpimqdflalrKVMKDTGALnmINpasaLFRSTMRryIHTPPSFAPIIQ
     ||.. | |||   .. ..  | .    |.. . |. . .  | ..            .| | | .|  .|    |.|  ..   ||    | .. 
..kviyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdm............gvpkytipl..mn....lirtvkq..hhtnsvgaivvh

SARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDY
   |  |.|.|. .| ..  .. .  |.  | ..| . ...||. | ||  . |||.|.|. 
csaGvGrtGtfitldavldqaeae..naidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 24-180 1.7e-16 55.0 In-house 26-184 (283) alignment
Range on Protein: 24-180
Range on HMM: 26-184/283.0
RVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLnrdGYINASLME---FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
 ...  |  . ||  .|||. .. |.| .       ||||. .      . ..||| .  | .. |  ||.|| ...  .|. ..   |.. ..  .|.|
diasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

DKGDVwSYGHLQVERKSYAIHQgNFHTRNFILRKG---NETHRVLHFTVFGWTETT-TPIMQDF
 .| .  || . |  .    ..  |  ....||.    ..|  . |. | .|.|    .|.  .
krGse.dyGeftvtlrkettsn.sfiikelllrvnssakstlllahyqvidWleygeqaiinsl

0042113 (Phosphotyrosine protein) phosphatases II 25-285 1.5e-39 131.3 In-house 3-243 (245) alignment
Range on Protein: 25-285
Range on HMM: 3-243/245.0
VTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkG
|....| ...|| . |.| ..  |.|.|   .  ..|||||.. .... .|.|.|. |... | .||.|. |... ||. . . .| . . ...|.|. |
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

DVWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKdtgalnminpasalfrstmrRYIHTPPSFAPI
... ||...|. .|. .  .....|.. .   . .|.. |.|.  ..| . ..|  ....| . . ..                    .... ...   .
esltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr....................kalaedsngpvl

IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
. .  | .|.|.|....|.....  .|.  .|.|. . . . .| ..|.   .  |.|||.|..|
VHCsaGvgRtGtfiaaylmleql..ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 25-294 1.5e-26 88.1 In-house 3-247 (250) alignment
Range on Protein: 25-294
Range on HMM: 3-247/250.0
VTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdNVEEKLEHYDKYFP-DK
|. ...  ..||  .|..     | | ..  ..   ||||| ..  |  . .| |  | .. .  ||.||||. | ||. .. |..|. . | .|.| .|
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLt.nLkesektyhqywPvek

GDvwSYGHLQVERKSYAIhQGNFHTRNFILRKGNETHR--VLHFTVFGWTETTTPIMQdflalrkvmkdTGALNMINPASALfrstmRRYIHTPPSfapI
 .   ||...|. .|  .  ... .|...| | .....  | ..  . | . . | .            | .|....   |      ...... |    |
ae..kyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPeva...........tavLellkkvqas.....qqqagnaPv...i

IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRrnprFQD
.| . | .|.|||..|| ..  .  || .   | ..| . .. |.| |     ..|.||..| .|      ..|
vqCsaGvgrsGafiaidavlerl..kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds....ved

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 25-299 9.7e-21 69.1 In-house 42-299 (319) alignment
Range on Protein: 25-299
Range on HMM: 42-299/319.0
VTARLEAVNRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPdKG
 . . |  ..||   |..  |  | |..    .   ||||| ..  .  .|.| |  | |. .  ||.|| |..| ...  .. ||.   .. ||.| . 
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp.ee

DVWSYGHLQVERKSYAiHQGNFHTRNFILRKGN---ETHRVLHFTVFGWTETTTPimqdflalrkvMKDTGALNMINPasaLfRSTMRRYIHTPPsfapI
....||.| |. ..   .. ..  |.. |.| .   || .| ||.   |..   |            | |. |....    . | ....  . |     .
nfeeyGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvP...........ekatslldllkr...i.rksrektqsgPi....v

IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN--PRFQDFKEPL
.  . |. | |.|.|.|  .  .  |. ..  |   . . .  |   |     ..|||||.|...   .   . ||... |
vhCsaGvGRtGtfivldamlerv..keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

0040439 (Phosphotyrosine protein) phosphatases II 26-286 8.8e-41 135.5 In-house 6-247 (249) alignment
Range on Protein: 26-286
Range on HMM: 6-247/249.0
TARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkGD
. ..| ...|| . |.| ..  |.|.. . |. ..|||||...........|.|. | .. | .||.|. |... .|. . . || . |....|.|. |.
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.gg

VWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstmrryihtPPSFAPII
.. ||...|. .|. .  .....|.. |   . .|...|||. ...| .. .|  ..|.|.. . ...  . .                   |..   ..
sleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...................pkggpvlV

QSARGSSRAGAFVVIDLLIRMIDgkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
 .  | .|.|.|....|......  |.. ...|. . . ...| ..|.   .  |.|||.|..||
HCsaGvgRtGtfiaaylmleqle..kelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 26-288 1.9e-25 84.4 In-house 15-267 (270) alignment
Range on Protein: 26-288
Range on HMM: 15-267/270.0
TARLEAVNRNRVVKIVPQHRYNVRLTPSMLN-RDGYINASLME-FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKG
 .     . ||   |.|. .  ||| .   . .  ||||  .. |..  .||| .  | .  ...||.|..|.....|.  .. .|.  .. ..|.| . 
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

DV---WSYGHLQVERKSYAIHQGNFHTRNFILrKGNETHRVLHFTVFGWTETTTPIMQDflalrKVMKDTGALNMINPASAlFRSTMRRyiHTpPsfaPI
.     ..|...|   | . ..|   ||  .  .  |..|..||    | . . | ..|     .... .  |.|..   . ... ...   . |    .
kekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreed.....sslstdqllkmlravrr.sekeldk..ae.P...ll

IQSARGSSRAGAFVVIDLLIRMIDgkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
.  . |  |.| ....|  .|...  .|.   |  .| . .. |. .|    .  |.|.||. |  ||
vHcsaGvgRtGtlialDiavrlLe..etkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_PTPRA_pd Subfamily PTPRA 26-287 6e-25 82.8 In-house 53-297 (330) alignment
Range on Protein: 26-287
Range on HMM: 53-297/330.0
TARLEAVNRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGd
... |  ..||||.|.| .   | |..    .   ||||| ..     .|.| .  | |. |  ||.|. ||.| ||. ...  | | |   .|.||.| 
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG.

VWSYGHLQVERKSYAIHQgNFHTRNFILR-KGNET-----HRVLHFTVFGWTETTTPImqdflalrkvmKDTGALNMINPASALFRSTMrryihtPpsfA
...||...|| .   . . ..  |.|... ....|       |  |   .| .   |.           .  | |....   .| . .           .
lvtyGnirvevedetvlv.dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf...........epiGmlkllkkvkklnqqsa......g...p

PIIQSARGSSRAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
 ..  . |  |.|.|.|.| .. ..  ..  .  | . . . .  | . |     . |||...|.| | 
ivvhcsaGvGrtGtfivldavlervkaer..kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 26-173 2.7e-14 47.8 In-house 40-187 (287) alignment
Range on Protein: 26-173
Range on HMM: 40-187/287.0
TARLEAV--NRNRVVKIVPQHRYNVRLTpsmLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKG
|  .     ..||. .|...  | | |     ... ||||. ..     ...|..  |  . .  ||... ... ..|.  ... |.. |   .|.|.. 
thniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

DvWSYGHLQVERKSYAiHQGNFHTRNFILRKGN---ETHRVLHFTVFGWTETT
   ..|. ..|  .   .. ..  |.. ... |   ....|  . .  | .| 
s.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstg

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 26-177 2.9e-14 47.5 In-house 33-186 (287) alignment
Range on Protein: 26-177
Range on HMM: 33-186/287.0
TARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV
.  | ||..||  ...|     | |.        ||||  .      ...| .  |    |  ||..|||.|| ..|  . .|||   .  ||.|..   
aeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevP

WSYGHLQVERKSYAIHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIM
   |   |   .| | . .. .| . |   ...|.. |  . .. | . . .  
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 26-289 1.5e-09 32.3 In-house 38-275 (288) alignment
Range on Protein: 26-289
Range on HMM: 38-275/288.0
TARLEAVNRNRVVKIVPQHRYNVRLTpsmLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGD
.. ...  |.|  ..       |.|.    . | ||.| ..  .   .. | .  | .  .  .|.|.||.    |. ... .|  .|. ..|||  .|.
dsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe

VWSYGHLqverksyaihqgnfhtRNFILRKGNETHRVLHFTVFGWTE-TTTPIMQDFLALRKVMKDTGALNMINPASALfrSTMrRYIHTPpsfaPIIQS
   .|.|                 . . .| .. ..... ...  .. . ....  .| |..  .|.   | . |   |    . . .. |     ...|
karigrl................ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll..evl.kslqkP....ivvhs

ARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
  |. |.|....| . ....  . ..  ... |. | .  | ... .   . ...  ||..|| . 
saGvGrtgtlililialesl..rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk

0045098 (Phosphotyrosine protein) phosphatases II 27-289 1.2e-39 131.8 In-house 29-276 (278) alignment
Range on Protein: 27-289
Range on HMM: 29-276/278.0
ARLEAVNRNRVVKIVPQHRYNVRltpsmlnrdGYINASLMEFSdvGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkGDVW
 .|. ...|| . |.|  .  |.         .|||||....   ..|.|.|  | .. | .||.|. |.....|.  .. || . |....|.|. |...
lylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsl

SYGHLQVERKSYAIHqGNFHTRNFILR------KGNETHRVLHFTVFGWTETTTPIMQ---DFLALRKVMKDTGALnminpasaLFRSTMRRYIHTPPSF
 ||...|. .|. .. .....| ....      ...|.. | |.  ..| . ..| .     || | . ...  .|        |.. .. .... ... 
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl........laslllsslllldsgg

APIIQSARGSSRAGAFVVIDLLIRMIdgkkTNLYSVEDLIVKCKHMRIH-CVPVALHHSFIYEAVLDYLLRRN
  ..    | .|.|..|...|.....     . ..... . . . .| . .|.   .  |.||..|..|||..
pvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 27-285 5e-12 40.3 In-house 29-295 (297) alignment
Range on Protein: 27-285
Range on HMM: 29-295/297.0
ARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVG--QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KG
 |  .. .||  .|.  .   |.|  .. .|| ||||  . | |     ||||.  | .. |  ||..| ||   .|.  |   |.  .    |.|. ..
krnsslrknryrdilatddtrvkllrviterd.yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

DVWSYGHLQVERKSYA-IHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTP-IMQDFLAL-RKVMKD----TGALNMINPASALFRSTMRRY-IHTPP
.    |.. ||  |    .  . .  .. |   .|.  | |   ..| .   |  ..|   .  .|          | ...  .|.    .  .  . | 
erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

SFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
.   ..  . |  |.|  |  | .. ..  .|  .  |  .. . .. |   |     . ..|.|||  |
nayllvhcsaGvGrsGvvvlsdvilakl..rkkripdvaailsilreqrarlvqtleqfellydavlkkl

0037934 (Phosphotyrosine protein) phosphatases II 28-284 1.1e-31 105.7 In-house 7-241 (243) alignment
Range on Protein: 28-284
Range on HMM: 7-241/243.0
RLEAVNRNRVVKIVPQHRYNVRLtpsmlNRDGYINASLMEFSDvgqKYILTGIPSEDKVFA----FWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPdkG
..| ...||.  |.|  .  |.|     . ..||||.|..  .   ..|.|. | .. |.     ||.|. |... .|. . . || . | ...|.|  |
lpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

DVwSYGHLQVERKSYAIHqGNFHTRNFILRK---GNETHRVLHFTVFGWTETTTPI-MQDFLalrkvmkdtgalnminpasaLFRSTMRRYIHT------
.|  ||...|. .|.  . .... |.. |.    ...|. | |.  ..| . ..|  ..|.|                     | . .| .|.       
ev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedll....................dfldevrefieellslla

-PPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgkktNlYSVEDLIVKCKHMRIH-CVPVALHHSFIYEAVLDY
 ...   ..    | .|.|......|.....     . ...|. . . . .| . .|.   .  |.|||.| .
ldsggpvlVHCsaGvgRtGtliaaylmllll.....g.vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPN14_pd Subfamily PTPN14 28-286 1.6e-25 84.7 In-house 45-297 (300) alignment
Range on Protein: 28-286
Range on HMM: 45-297/300.0
R-LEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQ--KYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK--
.  | ...||. ...| .   |.|.|.  |..|||||| .. |  |.  .|| .  | |  |  ||||| ||    |.. ... |.  |.  ||||..  
klpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

-GDVWSYGHLQVERKsYAIHQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPI-MQDFLALrkvmkdtgaLNMINPASALFRSTMRRYIHTPPsfa
  .   .|. .|  | .  . . . |. . |.    .|   |.|.    |..   |  ...||           |....     . |..    . ||   
kkktvefgkfkvttk.fsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy.........LeevqsvrrktnseveskeskPP...

PIIQSARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
 ..  . |  |.|  .. ||||  ..  ..    ..  . . .. | . |.    . |.|.... || 
vlvhCsaGvGrtGvlilsdlliatlehnee..idikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_PTPRK_pd Subfamily PTPRK 28-285 3.1e-23 77.1 In-house 40-277 (314) alignment
Range on Protein: 28-285
Range on HMM: 40-277/314.0
RLEAVNRNRVVKIVPQHRYNVRLTPSMLN-RDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVw
. |  ..||. .|..  |  |.|..   .    ||||.|..     ...| |  | .. |  ||..|..... .|.  .. ||.   .  ||.|....| 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

sYGHLQVERKSYAIHQgNFHTRNFILRK----GNETHRVLHFTVFGWTETTTPIMQDflALRKVMKDtgaLNMINPAsalfrstmrryihtpPSFAPIIQ
 ||...||  .  ... .. .| | ..|     .|.. | .|   ||..  .|  .   .| |...    ... ..                     .. 
.ygdikvelvetella.elvvrifrveklargqeeirevrqfqflgWpdhdvPvsat..gllklvrr...vkksqee...............eaGrivvh

SARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
   |. |.|.|..|| .. ||  .. ..  |   . . .  ..  | .   . |||...|.  
CsaGaGrtGtfiaidivldmi..eregvvdvfnavktlrsrkvnmveteeqykfiydvileac

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 28-190 8.3e-19 62.8 In-house 38-202 (281) alignment
Range on Protein: 28-190
Range on HMM: 38-202/281.0
RLEAVNRNRVVKIVPQHRYNVRLTPSMLNRD-GYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVW
. | |..|| . ||      |..||.  | .  ||||. ..  .  ..|| |  |  . . ||||||.||.  .|.  . ..|.   .  .|.||.    
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnsel

SYGHLQVERKSYAIHQgNFHTRNFIL-RKGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDT
.||...|. .. . .. .. .|.| | |...|| .| ...   | ..  |   ...|  || .. .
kygdvtvkstaeeeka.tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 28-175 1e-18 62.5 In-house 43-194 (305) alignment
Range on Protein: 28-175
Range on HMM: 43-194/305.0
RLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGD-V
. . ...||...|....   ..||..  .    ||||| ..  .  .|||..  | .. |  ||....| .  ||..... ||.. .   .|.|..   .
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktek

WSYGHLQVERKSYAIHQgNFHTRNFILRK---GNETHRVLHFTVFGWTETTTP
  .|...|| || .  . .. .|.. . .    .|.. ||.. .  | .   |
kefgefsvelksektas.dyieRklkisiededkesrtvlqyqltdWPdhGvp

subfamily_PTPRB_pd Subfamily PTPRB 29-288 7.9e-27 89.0 In-house 49-288 (293) alignment
Range on Protein: 29-288
Range on HMM: 49-288/293.0
LEAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWS
 .  ..||  .|.|     |.|..    . . ||||. ..     ...| |  |  . |  ||.||.|..| .|. . . ||.  .. ..|.|.. .   
avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvl

YGHLQVERKSyAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPimqdflalrkvmkdTGALNMINpasalFRSTMRRYIHTPPSFAPII-QSARG
||...|. ..   .. .. .|.. ..|..|...| ..    |..   |                . ....     |  |.|..|..  | .||.   . |
yGdikvtlva.eeeledwvirelkiekekeerkvrqyhftsWpdhgvP..............ektktlld.....fvrtvreaiektaskrPivvhCsaG

SSRAGAFVVIDLLIRMIDGkkTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
  |.|.|. .| |.. |.   ...  .  .... .. | . |    .. ||...|||.| ..
vGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

0049772 (Phosphotyrosine protein) phosphatases II 29-287 3.2e-12 42.3 In-house 44-282 (314) alignment
Range on Protein: 29-287
Range on HMM: 44-282/314.0
LEAVNRNRVVKIVPQHrYNVRLTPSMLNRDGYINASLMEFSdvgQKYILTGIPSEDKVFAF----------WQMVL--EQRSPTIIQ-------------
..  ..||  .|.|     |.|     .  .||||| .      .|.| |  |.|  |. |          |.|||  .... .|               
flnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------FADNVEEKlehydkyfpdkgD---VWSYGHLQverksyaihqgnfhtrnF-------IlrkgneTHRVLHFTVFGWTETTTPIMQDFLALRK
        . .  .              .   .. . .|.                                .......  . ..  ..|. .||... .
daAlgKtpllildgng............neptaadlellk.................eelydpelf......erlgikylripvpDgsaplledfdefle

VMKDTgalNminpasalfrstmrryihtpPSFAPIIQSARGSSRAGAFVVIDLLIRMIDgkktnlYSVEDLIVKCKHMRI-----HCVPVALHHSFIYEA
....    .                    .  . ..  . | .|.| |||...|..  .      .|.|. .   . .|      ....  ..  ||.||
fieea...d....................kggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilea

VLDYLLR
.|.|| .
lleylkf

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 29-123 9.4e-06 19.3 In-house 32-126 (332) alignment
Range on Protein: 29-123
Range on HMM: 32-126/332.0
LEAVNRNRVVKIVPQHRYNVRLTPSMlNRDGYINASLMEFSDVGQKYILTGIPSEDKV-FAFWQMVLEQRSPTIIQFADnVEEKLEHYDKY-FPDKG
|. .. ||. ..    .  | |.|    .| . ||| ..       ||..  | .|.  . ||.|| |..   |. | | ..|| ..   |   |.|
lnnmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd.idekqkrkapydisdrg

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 30-283 3.5e-27 90.2 In-house 46-277 (288) alignment
Range on Protein: 30-283
Range on HMM: 46-277/288.0
EAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWSY
.  ..||   |.|    .|.|.     .   ||||| .. ..  .||| |  |  | |  ||..| |... ||. ... ||.  .. ..|.||...   |
vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpkny

GHLQVERKSYAiHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNminpasalfrstmrryihtppSFAPIIQSARGS
|...|. ..   ....| .|...| | ..  .. ..   .|...  |   ...|.|.. .| .   .                     .   |.. . | 
Gsvtvtlvesk.eledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.....................tgpiivhCsaGv

SRAGAFVVIDLLIRMIDGkkTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
 |.| |...| || ...   ..   | . . | .. |   | .  .. ||||..|.
GrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_PTPRG_pd Subfamily PTPRG 30-290 1.5e-24 81.2 In-house 46-292 (563) alignment
Range on Protein: 30-290
Range on HMM: 46-292/563.0
EAVNRNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkGDVWS
|  ..|| ..||.  |  |.|.|     ..  ||||. ..    ....| |  |..| .  ||.|. ||.. .|.  .. ||.. .. | |.|   ..  
enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.deset

YGHLQVERKSYAI----HQGNFHTRNFILRKGNE---THRVLHFTVFGWTETTTPIMQDFlALRKVMKDtgalnminpasalfrstmrrYIHTPPSFAPI
||.|||  ..  .     . ..  .|..|.|...    ..| ..    | ....|  . .  |  | |.                       ..    ||
ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp.vLifvkks....................saankaeaGPi

I-QSARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
.     | .|.| ..|.| |.. |  .  |   | ... . . .| . |       |...|.|. .. .. 
vvHcsaGvgrtGtyivldtllkqiqqe..navnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

subfamily_PTPN23_pd Subfamily PTPN23 30-287 1.7e-23 77.9 In-house 42-282 (288) alignment
Range on Protein: 30-287
Range on HMM: 42-282/288.0
EAVNRNRVVKIVPQHRYNVRLTpsmLNRDGYINASLME-FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWS
  ...||   |.|  .  | |     ..| ||||| ..  | .  ..| |  | .  .  ||.|| ||.|..|.   .. | . .. |.|.| |||.  .
lyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGHLQVERKSYAiHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNMINPASalfrstmrryihtppsfaPII-QS
.|.|.|  ||   . ...  |...|.  . .... | |  .. |.|   |   ...|.. ......   .  .                     |.. . 
fgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt..................PlvvhC

ARGSSRAGAFVVIDLLIRMIdGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  |. |.|.| ..   .| .  |.  |  . ... . .. | . |    .  | ||||| .  |
saGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 30-286 4.3e-09 30.4 In-house 46-280 (303) alignment
Range on Protein: 30-286
Range on HMM: 46-280/303.0
EAVNRNRVVKIVPQHRYNVRLTPSmlnrdGYINASLMEFsDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVwsyg
. ...|| | ..     .|.|. |      || || .|. |  .| ||| .|       ||||..||.   .. .  . | .    |  || . |     
knmdknrfvdvicldhskvklsds.....syihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf....

hLQVERKSyaIHQGNFHTRNfiLRKGNEtHRVLHFTvFGWTETTTPIMQDFLALRKVMKDTGALNMINPASAlFRSTMRRYIHTPPsfaPIIQSARGSSR
 |. | .|  |  |.|.  .  | .|    .||  .  |   .   . .      . .   |. ....      .| .|.| .. |   ..  |  |  |
.lkfeers..irvgefkrve..lgdgwv.lkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwq.lqsvlrkysdstp...tvymslsgcgr

AGAFVVIDLLIRMIDGKKTNLYSVEDLiVKCKHMRIHCVPVALHHSFIYEAVLDYLL
||.| ...     .  ... |  |  |  . .  |.|.|      |..|  . ...|
agtfalfetahlslhseqasldlvkcl.envrngrlhavqnlsqfsvvytllaehvl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 30-140 1e-08 29.3 In-house 41-153 (301) alignment
Range on Protein: 30-140
Range on HMM: 41-153/301.0
EAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGDVWS
.|.||.. .......|  .. .|.  | .  ||||| ..     .|.| .  | .  .  ||.......  .|.  ..  |.. ..  .|.|. . .  .
kalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

YGHLQVERKSYAI
.|...|. .. ..
fgpftvtlvneqv

subfamily_ptpA1_pd Subfamily ptpA1 30-126 7.2e-07 23.3 In-house 46-144 (418) alignment
Range on Protein: 30-126
Range on HMM: 46-144/418.0
EAVNRNRVVKIVPQHRYNVRLTPsMLNRD--GYINASLMEFSdVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK--GDV
   ..||  .|.|  .  |.|   . ...   ||||  .. .   ...| |  |  . .  ||.|| |.|   |. .. . |.   . |.|.|..  |. 
hntsknrytnilpvnhtrvqlkk.iqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

W
.
f

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 31-289 3.9e-23 77.0 In-house 44-284 (318) alignment
Range on Protein: 31-289
Range on HMM: 44-284/318.0
AVN--RNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVwS
 ||  .|| . |..  .  |.|..   .    ||||. ..     ..|| .  |  . .  ||.|| || | .|. ... .|.  .  ..|.|.||   |
pvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.s

YGHLQVERKSyAIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTPIMQdflalrkvmkdTGALNMINPASALFRSTMRRYIhtppsfapIIQSAR
||.|.|| |.  .. ...  |.| ... .  |.  |  . .  |... .|              .. |...  .|.  ... .. |        ..  . 
ygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...........aslldlvrqvskaqqksgagpi........vvhCsa

GSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
|  |.| |...| |.. |  |. .|  | . . . .. |   | .   . |||...|..|   .
GvGrtGvfiavdilleri..kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 31-286 7.9e-22 72.6 In-house 28-269 (274) alignment
Range on Protein: 31-286
Range on HMM: 28-269/274.0
AVNRNRVVKIVPQHRYNVRLTPSMLNRD--GYINASLMEFSD-VGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV--
. ..||  .|.| ..  | |...  . .   ||||  .   | . . |. |  |    |. ||.|. ..... |.  ..  |.. .   .||||. |.  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-WSYGHLQVERKSyAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPimQDFLALRKVMKDTgalnminpasalfrsT------------Mrryih
   ||..... .. .... ... |...|.. .....| |.    | .. .|  .|  .| ......                            .     
serygdveikvek.iverndysvrklvlkylerersvkhywytdWPdhksP..ddantlldlvlev...............eesreeenaklapv.....

tppsfapIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
       ..  . |  |.|.|. |.. .| .  ....   |  .... .  |   |  .  . .|..|.  || 
.......vvhCsaGiGrtGcfiaisiavrql..reeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 31-292 2.2e-20 68.0 In-house 51-291 (297) alignment
Range on Protein: 31-292
Range on HMM: 51-291/297.0
AVNRNRVVKIVPQHRYNVRLTPSMLN-RDGYINASLMEFSDVgqKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNvEEKLEHYDKYFPDKGDVWsYG
  ...|   |.| ..  |.|     .    |.||| ..      ..| |  | .. |  ||.|||...  ||.  .|. .|. ..  .|..||| .  .|
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkgvtt.fG

HLQVERKSYAIHQGnFHTRNFILRKGN--ETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDtgalnminpasalfrstMRRYIHTPPSFAPIIQSARGS
.. |. .| .  .| |  |.. ..||.   .. |  .    | . . .  ..  .| |....                 .|    .  .   ..    | 
dvsvvllsvsereG.fikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklise.................vrkdfsqnaegPllvhclaGv

SRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRF
 |.| .. ||  .  .  |...   . .|. | .. | . |    ...|.|.|||..||  . | 
Grtgvlltidsvvaea..krekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtri

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 31-289 4.6e-09 30.7 In-house 41-281 (307) alignment
Range on Protein: 31-289
Range on HMM: 41-281/307.0
AVNRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGDVWSYG
  ..||   .  |..  . .. . |  | || |  .  .   .|.| .  | |. .. || |.....  ..| ... .|    . ..|.|  .|.   .|
ntdknryqdvkcqdkgrivvkfdglasd.yihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfg

hlqveRKSYAIHQGNFHTRNfiLRKGNETHRVLHFTVfGWTETTTPIMQdfLAlRKVMKDTGALNMINPASALFRSTmrRYIHTPpSfapIIQSARGSSR
      .. .|   |. ...  |   ..   |  . |  |.. .  | .  |   .   | |. ..   |  |. ..  || . |     ..  . |  |
.....eapntisvanlgakk..lapdedlinvttlkv.dwaqksrtiqh..lq.wenwpdrgvpqinltainlleav..rydtnp.v...vvhcsaGvGr

AGAFVVIDLLI-RMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
.|. | | |.  .||.|.  |  ....|. . .  | ...   . . ...  .|.|.| . 
sGtivaislvqdkmiaGi..nckdmkklveelrsqrhyaiqteaqylylhrvlleyflely

subfamily_PTPRD_pd Subfamily PTPRD 32-288 8.4e-30 98.9 In-house 49-284 (564) alignment
Range on Protein: 32-288
Range on HMM: 49-284/564.0
VNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGdVWSYGH
 ..||. .||.  .  |.|..    .   ||||| ..  .  ..|| |  | .. .  ||.|| ||.| ||.     .|.. . ..||.|.||   .||.
kaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetyge

LQVERKSyAIHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGAlnminpasalfrstmrryihtpPSFAP-IIQSARG
|.|. ..   .  ... |.|.|.|   .|.. | .|    | ..  |   ...|.|.. ....                        |   | ...   |
ltVtlee.eeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne......................pdagPivVhCSaG

SSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
  | |.|.||| ... |  |. ..  .   . . .. | . |      .||.||.|..|   
VGRTGtfividamleri..keektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 32-290 3e-21 70.1 In-house 44-281 (515) alignment
Range on Protein: 32-290
Range on HMM: 44-281/515.0
VNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGDVWSYG
 ..||   |.| ..  |.|          |.||| ..  |  . || .  | .  |  ||..||...  ||.  ..  |.   .  ||.||  ||   .|
fkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

HLQVERKSYAIHQGnFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMqdFLALRKVMKDTgalnminpasalfRSTMRRYIhtppsFAPIIQSARGSSR
...||  |     |    |.. . ||.... |  |   .| .  .|      .| |..|.              ..   .|      .. ||  . |  |
sikvelvsleactg.gikrkltvlkgddsrtvtqfhfteWPdkGvpkh..tssllklikev.............kadhgqyt.....hpliihcsaGvGr

AGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
.| .. ||  .  .  |.|.   | ... . .  | . |    ...|||.|||..|| || 
tGvvisidsvvaha..kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt

subfamily_PTPN9_pd Subfamily PTPN9 32-287 2.7e-20 67.6 In-house 43-292 (297) alignment
Range on Protein: 32-287
Range on HMM: 43-292/297.0
VNRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWSYG
...||   ..   .  | |.     .   ||||. ..     . .| |  | .  |  ||.|| ||.  .|.  .  ||..     .|.| ..... ..|
leknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg

HLQVERKSYAiHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGALnminpASALFRSTMRRYIHTPPSfapIIQSARG
.|.|.. .   .. ....| . ..  | .|. .| || . .| .  .|   ...| ........ ||     |.  . .. .  .. ||    ..  . |
dlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal.....avkelgdewkghpsgPPi...vvhcsaG

SSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  |.|.|. .|. .  .  ....   | . . . .  | . . .   . | | |||.| |.
iGrtGtfitldiclsrl..eevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

Y_phosphatase Protein-tyrosine phosphatase 33-282 4.7e-36 119.7 Pfam-A 3-234 (235) alignment
Range on Protein: 33-282
Range on HMM: 3-234/235.0
NRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWSYGHL
..||  .|.|  .  |.|. |  . | ||||. ..  .  .|.|.|  | .. .  ||.||..... .|.. ....|.. |....|.| ....  .||..
kknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

QVERK-SYAIHQGNFHTRNFILRKGNET---HRVLHFTVFGWTETTTPimQDFLALRKVMKD----TgalnminpasalfrstmrryihTPPSFAPIIQS
.|| | .   .. .. .|.. |.| .|    ..| .. . .|.. ..|  ..  .| .....    .                      .. |   ....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk......................eaksgpvvVhC

ARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVL
  |..|.| ||..|.|..... ...   .| ... . .. |...|  .    |.|.|.|
saGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 33-282 4.7e-36 119.7 In-house 3-234 (235) alignment
Range on Protein: 33-282
Range on HMM: 3-234/235.0
NRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWSYGHL
..||  .|.|  .  |.|. |  . | ||||. ..  .  .|.|.|  | .. .  ||.||..... .|.. ....|.. |....|.| ....  .||..
kknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

QVERK-SYAIHQGNFHTRNFILRKGNET---HRVLHFTVFGWTETTTPimQDFLALRKVMKD----TgalnminpasalfrstmrryihTPPSFAPIIQS
.|| | .   .. .. .|.. |.| .|    ..| .. . .|.. ..|  ..  .| .....    .                      .. |   ....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk......................eaksgpvvVhC

ARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVL
  |..|.| ||..|.|..... ...   .| ... . .. |...|  .    |.|.|.|
saGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 33-285 5.2e-16 54.0 In-house 27-256 (284) alignment
Range on Protein: 33-285
Range on HMM: 27-256/284.0
NRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdnveekLEHYDKYFPDKGDVwSYGHL
..||...|..  .  |.| . .  .   ||||| ..     .||| |  | .. .  ||.|. |... ||. ..       ..  .|.| |...  ... 
dknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerf

QVERKSYAiHQGNFHTRNFILRK-GNET--HRVLHFTVFGWTETTTPIMQdflalRKVmkdtgaLNMINPASALFRStMRryiHTPPSfapIIQSARGSS
.|. .|      ..  |.. | . |.|.   ..  |   || .   | .       ..      . ...  . | .  ..   |  .    ..  . |. 
kvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp.....sdl......mrlvkkvrhltsk.en...hrani...vvhcsagvg

RAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD-YL
|.|...|.| |. ... .|     | ... . .  | . |     . ||| |.|. .|
rtgvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 33-285 7.6e-16 53.3 In-house 63-292 (319) alignment
Range on Protein: 33-285
Range on HMM: 63-292/319.0
NRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdnveekLEHYDKYFPDKGDVwSYGHL
..||...|..  .  |.| .    .   ||||| ..     .||| .  | .. .  ||.|. |... ||. ..       ..  .|.| |...  ... 
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerf

QVERKSYAiHQGNFHTRNFILRK-GNET--HRVLHFTVFGWTETTTPIMQdflalRKVmkdtgaLNMINPASALFRStMRryiHTPPSfapIIQSARGSS
.|. .|      ..  |.. | . |.|.   ..  |   || .   |         ..      . ...  . | .  ..   |  .    ..  . |. 
kvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp.....sdl......mrlvkkvrhltsk.en...hrani...vvhcsaGvG

RAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD-YL
|.|...|.| |. ... .|     | ...   .  | . |     . ||| |.|. .|
rtGvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

0041856 (Phosphotyrosine protein) phosphatases II 33-290 2.1e-15 52.3 In-house 3-176 (182) alignment
Range on Protein: 33-290
Range on HMM: 3-176/182.0
NRNRVVKIVPQHRYNvrltpsmlnRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdnveeklehYDKYFPdkgdvwsyghlq
..||...|.| ..              ||||.|. .|  ....|.|  |  . | .|..|. |..  ||.  .          . |.|            
dknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

verksyaihqgnfhtrnfilrkGNETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDtgalnminpasalfrstmrryihtpPSFAPIIQSARGSSRAGA
                       .... ....  ..|   ..| ....|.. . ...                         .. . ..    | .|.|.
......................ellerlgiqylylpwpDhgvpdldelldfieevle.........................eggpvlVHCsaGvgRtgt

FVVIDLLIRMidgkktNlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
.|...|....      . .|.|. .   . .| ..|    .. |.. |.|..||... 
lvaaylmkkl......g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 33-283 2.7e-12 40.8 In-house 50-277 (439) alignment
Range on Protein: 33-283
Range on HMM: 50-277/439.0
NRNRVVKIVPQHRYNVRL--TPSMlNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEkLEhydkYFPDKGDVWsYGH
 .||  ....    .| |  .| .     ||||  ..     . || | .|.....  ||..|.|... ||..... ||        |.| ...|  || 
tknrykdvgafdhtrvtlqeipgv.phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves.yk....ywpsdaevc.ygd

LQVeRKSYAIHQGNFHTRNFILR----KGNETHRVLHFTVFGWTETTTPIMQDFLAlrKVMKdtgALNMINPasalfrstMRRYihtPPSfapIIQSARG
. | |    |   |.  | | .     ...  . ||.|    | .   |    ..   . ..   |.|  |          . |    |    ... . |
iav.rvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl..dflr...ainsand........keey...gpv...vvhcsag

SSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
  |.|. . .|. .  .  |  |   .. ..   .. | . |    .. |||.|||.
vGrtGtiialdialeql..klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 33-157 9.8e-08 26.3 In-house 35-153 (267) alignment
Range on Protein: 33-157
Range on HMM: 35-153/267.0
NRNRVVKIVPQHRYNVRLTPSMLNrdgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHydkYFPDK-GDVWSYGHL
.|||. . .| .   | |  .  .   ||||| .|    ....|.| .| .  .  |.... .|. |.|.      ....     ..| | |.   |  |
ernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPkmgqakkyqdl

QVERkSYAIHQGNFHTRNFILRKGNE
 ||. |    . ...   . |.  ||
tveh.slekeendyqiitlelkfkne

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 34-265 1.5e-13 45.5 In-house 6-219 (237) alignment
Range on Protein: 34-265
Range on HMM: 6-219/237.0
RNRVVKIVPQHRYNVRLTPSMLNRDgYINASLM-EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWSYGHLQ
.||  .||      | |  .  . | ||||. . .|    .||| .  | |     ||||| ...   |. ..  .| . ..  ||.|.  .  .|| | 
knrygnivaydhsrvvlkgagsgsd.yinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VERKSYAiHQGNFHTRNFILRKGNETHRVLHftVFGWTETTTPImqdflalRKVMKDTGALNMinpasaLFRSTMRRYIHTPPSFAPIIQSARGSSRAGA
|  |    .  ..  | ..| |  . . |    .. .  |. |        | | . | ||        . .  . |  | . |   ||  . |  |.| 
vslkkke.efsdytvrslllskrltlkevrl..ihqyqftswpd.......rgvpqqtaallr......frkniinrsphvsesgpwiihcsagvgrtgi

FVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRI
|.||| ..|    ||     . . .   .  | 
flvidamlrqakekkv..vdiynyvysieedrp

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 34-283 5e-10 33.9 In-house 10-238 (239) alignment
Range on Protein: 34-283
Range on HMM: 10-238/239.0
RNRVVKIVPQHRYNVRLT-PSMLNRDGYINASLM-EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDvwSYGHL
.||  .||   .  | |   |   .  ||||| . ..    . || |    | .   ||.|. ..|   |. ..  .| . ..  .|.||      |  |
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnl

QVERKSYAIHqGNFHTRNFILRKGNETHR--VL--HFTVfgWTETTTPIM-QDFLALR-KVMKDTgalnminpasaLfrstmrryihtPPSFAPIIQSAR
.|  .   .   ..  | |.. .  .|    |   ||||  | .   |      | || |. ||.           |           | .   .|. . 
rvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkds...........l...........pgarpwvihcsa

GSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
|  |.|||.||| ..|    .||    . . .   .  | | |  . .. ||. |||.
gvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 34-283 6.2e-10 33.6 In-house 11-239 (239) alignment
Range on Protein: 34-283
Range on HMM: 11-239/239.0
RNRVVKIVPQHRYNVRLT-PSMLNRDGYINASLM-EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDvwSYGHL
.||  .||   .  | |   |   .  ||||| . ..    . || |    | .   ||.|. ..|   |. ..  .| . ..  .|.||      |  |
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnl

QVERKSYAIHqGNFHTRNFILRKGNETHR--VL--HFTVfgWTETTTPIM-QDFLALR-KVMKDTgalnminpasaLfrstmrryihtPPSFAPIIQSAR
.|  .   .   ..  | |.. .  .|    |   ||||  | .   |      | || |. ||.           |           | .   .|. . 
rvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkds...........l...........pgarpwvihcsa

GSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
|  |.|||.||| ..|    .||    . . .   .  | | |  . .. ||. |||.
gvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 34-181 1.2e-07 25.7 In-house 40-189 (281) alignment
Range on Protein: 34-181
Range on HMM: 40-189/281.0
RNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV-WSYGH
.|| ..|       |.|   |   |   || |  .    . . ||||  | ..    ||.|. .. . .|. ... .| . |.  .||| .  .   . .
knrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdk

LQVERKSYAIHQGNFHTRNFiLRKGNETHRVLHFTVFGWTETTTPIMQDFL
| |. .  .. .    ||   |    ||. . |.    | .   |   . .
lsvsyedstvnkslvttrln.lsyegetrlithwlwkewpdwqvpessevm

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 42-125 1.5e-07 25.3 In-house 107-184 (244) alignment
Range on Protein: 42-125
Range on HMM: 107-184/244.0
PQHRYNVRLTPSMLnRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIqFADNVEEKlehyDKYFPDKGDV
|     | |. . .  . |||||..       .||||  |  |  . ||.|.||.    ..     |||.    |.|.||   .
pfdfnrvplskgsm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlv.vlgsveee....deywpdsepl

0051429 (Phosphotyrosine protein) phosphatases II 55-287 1.6e-13 46.4 In-house 1-227 (272) alignment
Range on Protein: 55-287
Range on HMM: 1-227/272.0
LNRDGYINASLMEFSdvGQ-----KYILTGIPSEDKVFAFWQMvLEQRSPTIIQFADNVEEKLEHYDKYFP-----------DKGDVWSYGHLQVERKSY
|. .|||||. .     |.     .....| |..  .  ||..  |..  ||. . . .| . . .|.| |           |     .||.| |   |.
lplsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

AiHQGNFHTRNFILR---KGNETHRVLHFTVFGWTETTTPImQDFLALRKVMKDtgalnminpasalfrstmrryihtppSFAPIIQSARGSSRAGAFVV
  .. ... |...|.   . .|...|.|..  .|    .|  . .|.| ... |                          . . ..  . | .| | .|.
e.llldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld..........................ggpvlvHCsaGkdRTGtvva

IDLLIRMIDGK-------KTNLYsVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
..||.. ..         .|||| .|. . . . .| . |.   .  |.|||.|..| .
llllllgvsletivddYlltnly.leeaveelraqrpgavqteeqylflyeallellrs

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 55-114 1.5e-07 25.2 In-house 67-127 (347) alignment
Range on Protein: 55-114
Range on HMM: 67-127/347.0
LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQ-FADNVEEKLEH
 . ..||||| . | .  ..||||  |  | |  ||.||   .   ..  |    .| .| 
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 55-122 2.1e-06 22.1 In-house 10-72 (130) alignment
Range on Protein: 55-122
Range on HMM: 10-72/130.0
LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSpTIIQFADNVEEKlehyDKYFPDK
|. . |||||..  ..  ..|.||  |  |.   ||.|.||.    ..     |||.    |.|.|| 
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryv.nvlvvlgsveee....deywpds

0044763 (Phosphotyrosine protein) phosphatases II 56-284 1.7e-08 29.8 In-house 11-170 (178) alignment
Range on Protein: 56-284
Range on HMM: 11-170/178.0
NRDGYINASLMEFSDVGQKYILTGIPSedkvFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDvwsyghlqverksyaihqgnfhtrnfilrkg
|. |.  .  . .| .   ..|.. |.     ...... |.   .|. .....|   ...|.|.|.. .                               
nleglersdyinaseilpglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

netHRVLHFTVFGWTETT-TPIMQDFLALRKVMKdtgalnminpasalfrstmrryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMidgkktNLySVE
    ..||. . ...... . ....|... .                            ..  . ..    | .|.|..|...|....      .| |.|
...iqylhipipDhgvpdllehflefvefieeal........................dekggpvlVHCsaGvgRsgtlvaaylmkkl......gl.sle

DLIVKCKHMRIhCVPVALHHSFIYEAVLDY
. |   . .|  .||   .  ..||  | .
eaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 56-136 1.6e-07 25.0 In-house 73-156 (302) alignment
Range on Protein: 56-136
Range on HMM: 73-156/302.0
NRDGYINASLMEFSDVGQKYILTGIPSEDKV---FAFWQMVLEQRSPTIIQFADNVEEKLeHYDKYFPD-KGDVWSYGHLQVERK
. | |.||| .|  ..... ||. .|  | .     ||.|| ...  ..   . . | |    ...||   ||   ||.. |  .
epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnr

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 56-287 3.4e-06 21.0 In-house 65-278 (312) alignment
Range on Protein: 56-287
Range on HMM: 65-278/312.0
NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkgdVWSYGHLQVERkSYAIHQGNFHTRNfiLRKG
. . || | ..      .... |  | |. .  |||..|   | .|| ..  ||.  |.  ||  |   . .. .|.  |  |. .  .         | 
denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd...ivgfvdledhr.vyteycteieigg..kskd

NETHRVLHFTVFGwTETTTPIMQDFLAlrkVMKDTGALNMINPASALFrSTMRRyiHTPPSfapIIQSARGSSRAGAFVVIDLLIRMIDGKktNLYSVED
. |||||.  |   |   . . .   |      | |  .  . |  |. |....     |    | . . |  |.|....|. .|  .         | |
kithrvlkvvvka.tgqesklnhyqwa...swpdhgmpdscdtalrll.savkk..dkkpv...iahcsagvgrtgtlaliesmiaalrhp..rkqnvkd

LIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  |  .. |   | |  .. .   .||..|  
sfvllrkdrarsvrvfpqyvyalrcvleflys

0043147 (Phosphotyrosine protein) phosphatases II 57-279 3.5e-13 45.1 In-house 4-155 (172) alignment
Range on Protein: 57-279
Range on HMM: 4-155/172.0
RDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNveeklehydkyfpdkgdvwsyghlqverksyaihqgnfhtrnfILRKGN
.. |||||..... . ...| |  |    .  ||.|. |.   .|.   .                                             . . .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

ETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGALNMinpasalfrstmrryihtppSFAPIIQSARGSSRAGAFVVIDLLIrmidgK-KtnlySVED
... ....  ..|   ..|... .| . . ...  ||.                     . . ..    | .|.|..|...|..     .      |.|.
lerlgiqylylpwpDhgvpllellleflefidellalsp....................ggpvlVHCsaGvgRtgtlvaaylml.....lgl....slee

LIVKCKHMRIHCVPVALHHSFIYE
 .   ...| ..|.   .. |.|.
avalvrekRpgavqnpsqyrflyy

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 57-182 2.1e-09 31.9 In-house 45-182 (290) alignment
Range on Protein: 57-182
Range on HMM: 45-182/290.0
RDGYINASLMEFSDvGQKYILTGIPSEDK-------VFAFWQMVLEQRSPTIIQFADNVEEKLEHYD----KYFPDKGD-VWSYGHLQVERKSyAIHQGN
 |.|| |. . ... |.. |||  | |.        .. || |. . ..  ...  .. |.. .  .    ||.|.. .    .. |.|. ||  ... .
nddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCks.kekedd

FHTRNFILR-KGNETHRVLHFTVFGWTETTTPIMQ-DFLA
. ||. ...  ..| . | |  . ||... ..  .  .|.
vetRelvvkfddeeeftvtHsllkgWnklnvqedtktlls

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 57-122 1.8e-07 24.8 In-house 89-156 (349) alignment
Range on Protein: 57-122
Range on HMM: 89-156/349.0
RDGYINASLMEFS--DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK
 | ||||  ....  .| .||| | .|.   |  |....| .. . ..   |. |. || .|.|. . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel

0036282 (Phosphotyrosine protein) phosphatases II 58-279 2.9e-16 55.1 In-house 2-164 (174) alignment
Range on Protein: 58-279
Range on HMM: 2-164/174.0
DGYINASLMEFSDVGQKYILTGIPSEdkvfaFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkgdvwsyghlqverksyaihqgnfhtrnfilRKGNE
. ||||| . .| .  ..|... | .     ||.|. |... |.... . .| .|.    |.|.                               ..  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

THRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGalnminpasalfrstmrryiHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDgkkTNLYSVEDLI
.. ....  ..|   ..| .. .| . | ...                        .|.   ..    | .|.|..|...|..|..    ..|  . ||.
erlgiqylylpwpDhgvpdlsillefvkfveeal....................sedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlv

VKCKHMRIHCVPVALHHSFIYE
 ... .| ..|.   .  |.|.
relRlqrpgmvqtpsQyrflyy

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 60-284 1.4e-10 35.3 In-house 83-282 (290) alignment
Range on Protein: 60-284
Range on HMM: 83-282/290.0
YINASLMEfsDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQGNFHTRNFILRK--GN
|. |  ..   .   .|||  . .| |. .|.|||...  .|. . . .|.   . ..|.|.| |.| ..|.. |       .. |   . . .|.    
yvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsG

ETHRVLHFTVFGWTETTTPImqDFLALRKVMKdtgalnminpasalfrstmrrYIHTPPSFApIIQSARGSSRAGAFVVIDLLIRM-IDGKKTNLysvED
  |.. |. .  | . . .     ||| ....                      . . .    ..  . |  |.|.|| |.  ... .|||. .|    |
kehklkhlkikswpdksval..stlallrtlr.....................ilrkasGpv.vvhcsaGiGrtGtfvaievglqilldGkeldl...ld

LIVKCKHMRIHCVPVALHHSFIYEAVLDY
|.   .. |.  | | . .  . |..||.
lvralrnsrlnsvqvdiqylalveilldl

0046846 (Phosphotyrosine protein) phosphatases II 60-284 1.6e-10 36.5 In-house 14-172 (176) alignment
Range on Protein: 60-284
Range on HMM: 14-172/176.0
YINASLMEFSdvgqKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkgdVWSYGHlqverksyaihqgnfhtrnfilrkgneth
||||.|.  |    ..| |  | .. . .|..|..|..  ... . . || .  . . |.|.   ....|.                             
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.............................

rvlHFTVFGWTETTTPIMQDFLALRKVMKDTGALNmiNPasalfrstmrryihtppsfaPIIQSARGSSRAGAFVVIDLLIRmidgkkTNLYSVEDLIVK
   .. ...| . ..| ....| | . ...    .  .|                     ..    | .|.|..|...||..       . .|||. . .
...qylhlpwpDhgvpdlelllellefirealkeg..gp....................vlVHCsaGigRtgtlvaayllel......ekglsveealal

CKHMRI-HCVPVALHHSFIYEAVLDY
 . .|  ..|.   .  |.||..| .
vreqRplgavqtpeQyrflyefelll

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 63-175 7.8e-07 23.1 In-house 80-197 (301) alignment
Range on Protein: 63-175
Range on HMM: 80-197/301.0
ASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKS-YAIHQGNFHTRNFILRKG---NE
|  .. |   ...| |  | ..    || |.      .|. .. .||.. |. ..|.| | ..    |  ... |.   | . . . |.. ..      .
anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfa

THRVLHFTVFGWTETTTP
|. |.|.    ||.  .|
trtvthyqysewtdrgvP

0051082 (Phosphotyrosine protein) phosphatases II 66-279 1.7e-10 36.2 In-house 6-147 (151) alignment
Range on Protein: 66-279
Range on HMM: 6-147/151.0
MEFSDVGQKYILTGIPSEdkvfAFWQMVLEQRSPTIIQFADNVEEKleHYDKYFPDKGdvwsyghlqverksyaihqgnfhtrnfilrkgnetHRVLHFT
  ||.|.  ....| |..    .|.... |.   ||. . . .| .  .. .|.|. |                                   ..|||. 
infsyvtgglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................ievlhip

VFGWTETTtpimqdflalrkvmkdtgalnmiNPASALFRSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMidgkktnlYSVEDLIVKCKHMRI
...|....                        | |  .   . ...  ...   ..    | .| |..|...|....        .|.|. .   . .| 
ildwpdpg.......................lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkrp

HCVPVALHHSFIYE
..|    .. |.. 
gvvqpnqqflfqlf

0049260 (Phosphotyrosine protein) phosphatases II 69-278 2.8e-06 22.6 In-house 5-143 (152) alignment
Range on Protein: 69-278
Range on HMM: 5-143/152.0
SDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFpdkgdvwsyghlqverksyaihqgnfhtrnfilrkgnethrvlhftvfg
   ....| |  | .  .  ||.|. |.   ||.   . .| . .  ..|.                                                 
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................

wtetttpimqdflalrkVMKDTGALNMINPASALFRSTMRRYI---HTPPSFAPIIQSARGSSRAGAFVVIDLLIrmidgkktNLYSVEDLIVKCKHMRI
                   . .    .  | .. .   . . |      ..   ..    | .|.|..|...|..        . .|.|. .   . .| 
.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRp

HCVPVALHHSFIY
. ||   .  |.|
gavpnpgqlrfly

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 73-181 1.1e-08 29.6 In-house 5-117 (199) alignment
Range on Protein: 73-181
Range on HMM: 5-117/199.0
QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQgNFHTRNFILRK----GNETHRVLHFTVF
..|| |  |  . .  ||||| |  |  |.   |.  .|   |  |.|     .  || | |  |. . .  ..    .|| .       |  . |.   
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dytitaliltnnttappstreishyqft

GWTETTTPIMQDFL
 | | ||| .  |.
swkekttpnvalfv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 73-181 1.1e-08 29.5 In-house 4-116 (198) alignment
Range on Protein: 73-181
Range on HMM: 4-116/198.0
QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQgNFHTRNFILRK----GNETHRVLHFTVF
..|| |  |  . .  ||||| |  |  |.   |.  .|   |  |.|     .  || | |  |. . .  ..    .|| .       |  . |.   
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dytitaliltnnttappstreishyqft

GWTETTTPIMQDFL
 | | ||| .  |.
swkekttpnvalfv

subfamily_hpo-7_pd Subfamily hpo-7 85-291 9.4e-10 32.8 In-house 46-233 (263) alignment
Range on Protein: 85-291
Range on HMM: 46-233/263.0
KVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV-WSYGHLQVErKSYAIHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIM-QDF
.. .|.|..  ... ... ..|  ||  |. ..||| . |    . ...|   . ....   .|....   |   .|| | |.   || |.  |   .. 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc.ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LALRKVMKDTGALNMInPASALFRSTMrryihtppsfapiiqsargssragaFVVIDLL----IRMIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSF
| . || ..   | .   ..   ||                           |.|..|.    || .|  .|       |. . ...|   ..  .. .|
lnilkvarnskslvvh.cstGiGrsaa.........................fsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

IYEAVLDYLLRRNPR
    |||..|  ...
silmvLdfvlnnfak

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 85-189 1.6e-08 29.0 In-house 40-147 (255) alignment
Range on Protein: 85-189
Range on HMM: 40-147/255.0
KVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGD-VWSYGHLQVERKSyAIHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIM-QDF
 | .|.|..  ... ... ..|  ||. |. ..||| . |    . ...|     .. .  ..|.. ..  |   .|| | |..  || |  .| . .. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LALRKVMKD
| . ||..|
lnilkvvrd

PTPc_DSPc_SM00012 161-282 2.9e-09 32.4 In-house 2-104 (105) alignment
Range on Protein: 161-282
Range on HMM: 2-104/105.0
VLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNMInpasalfrstmrryihtppSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKtNLYSVEDLIVK
| |. . ||... .|  ....| | . .|.    .                     |   ....  | .|.| ||..|.|..... .. . ....... .
vkhyhytgwpdhgvPeesdsilellravkknknkses...................skpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivke

CKHMRIHCVPVALHHSFIYEAVL
 ...| ..|      .|.|.|.|
lrkqRpgmvqteeqylflyrall

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 203-286 7.8e-09 30.0 In-house 195-277 (281) alignment
Range on Protein: 203-286
Range on HMM: 195-277/281.0
FRSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNLySVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
||. .... ..    . .|  . |  |.|... .| |.. .. ....| .|.... . .. |   |   . ..|.| ||||.| 
frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleel.dvkavvaelrkernlmvqtvvqyefvykavldald