Gene T13H5.1 in Caenorhabditis elegans

Synonym: CELE_T13H5.1, CELE_T13H5.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Ptp36E
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP183_AA protein Get Run
CeleP183_AA_191-468 phosphatase_domain Get Run
CeleP183_AA_501-800 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRB_pd Subfamily PTPRB 185-467 2.9e-59 195.5 In-house 4-285 (293) alignment 
Range on Protein: 185-467
Range on HMM: 4-285/293.0
TSPVDASKFVAYVQERR-KKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVR
..|. ..|| ..|.. . .  . |. || ...    .... ..  ..  ..| | . ||||..|| |  ......| ||||.|..     . ...||   
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

TKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT--KFQFREIEVETTEVKTYSHFVIRTFKLTRttpeSIETRIVKHFHFTEWELDSFPYI-
 . .. .|||||||  |. |||||....  .| | .||| .    .. .|.|. .. ......|||..|...    . |.| |...||| |     |   
petvd.dfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPekt

SAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
...... |.||. .||.  ..|.||||| | ||.|.|.|||  |. ....  .| |     | ..| .|. ...||.||.... . .
ktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPRD_pd Subfamily PTPRD 186-504 1.5e-79 263.1 In-house 3-317 (564) alignment 
Range on Protein: 186-504
Range on HMM: 3-317/564.0
SPVDASKFVAYVQERR-KKRILFKGEYLMVNRSiDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRT
 |.  ... ..|.. . .. . |. ||  .... .. ...    ..   .| | . ..|| .||.| ...|||.|.|||||..... ..|||. ||.   
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

KPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT-KFQFREIEVETTEVKTYSHFVIRTFKLtrTTPESIETRIVKHFHFTEWELDSFP-YISA
. . ..|||||||  |..||||||. .  .| | .||| . . .. |..|. .| .......||||||  .. .| |.| |..||||.|     | .  .
eti.edFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesats

FIELRRRVRQFMEknPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMHLLKER
...|.|.||.  |  | . |.|||||.| ||.|.|...|| || .|. ...| ..| |.| . |...... |||.||.|.. ||. | .. .|.. ||..
lLdlirkvralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh

SSMYKAKKnRELLETQETHENK
 .. . .. ..   |.  .| .
lqkLaeve.edtemtgleleFq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 186-475 7.4e-52 171.3 In-house 8-292 (297) alignment 
Range on Protein: 186-475
Range on HMM: 8-292/297.0
SPVDASKFVAYVQERRKKRIlFKGEYLMVNRSIDNNKCRCDVgSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRdkAYVVTQAVRTK
 |.  |.| ..||. |.  . |. |.| . ..   ..   .     .... | . |||| .||.|  .. | .| |.|||.|..      .. ||     
rpiplsdfatlvqknrhtdv.fseeflclpeaniqpqtvaek.kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

PMnAEFWRMVWELGSNCIVMLTKVFDFMRvMCLQYWPLT-KFQFREIEVETTEVKTYSHFVIRTFKLTRTTPEsiETRIVKHFHFTEWELDSFPY---IS
 . |.||.||..   . ||||..  .  .  | .||. .   .| .. |... |.  . |. |....|.  .    .|.|| ..|.||  .. .    .|
tv.adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkak..arrvvkqyqfveWPdkaverkdsas

AFIELRRRVRQFMEKNPvEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIE
....|   ||.  ..|  |.|..|||..| || | .|..|  .  .|.. ..| |.. | | ..||.|.   ||| |.|... ||.... . |.
sllklisevrkdfsqna.egPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 187-470 4.6e-52 171.8 In-house 2-281 (315) alignment 
Range on Protein: 187-470
Range on HMM: 2-281/315.0
PVDASKFVAYVQERRKkRILFKGEYLMVNrSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKP
|.  ..| |.|.. |.   ||  |.  .    |  . |    .  . .| | . ||.| .||.|  || . .| ||||||..|   ||||. .|.     
pipvaqfpafvnknrh.talfseefhdlp.dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

MNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPL---TKFQFREIEVETTEVKTYSHFVIRTFkLTRTtpeSIETRIVKHFHFTEWELDSFP-YISA
.. .|||||..     |||.||  .  .. | ||||       .| .|.||. .... .  |.| .  ||    | |.| |  |.||||     .   |.
vd.dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrk...seesrtvtqfqftewPdkGvdkqtss

FIELRRRVRQFmeKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM-CN
...| . |.    ... | ...|||| |.||.| ....|  .. .|.|  .| |.. |.| . ||.|. . |.| |||... | ..  |
llklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 187-469 7.5e-39 128.2 In-house 3-238 (392) alignment 
Range on Protein: 187-469
Range on HMM: 3-238/392.0
PVDASKFVAYVQERRKKrILFKGEYLMVNrSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKP
|. ...| |.|.. |.   || .|.  .  . |  . ..      . .| | . |||| .||.|  ||   .| |.||||..|   .|||. .|.  .  
pipvaqfpafveknrhs.alffeefhdlp.gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

MNaEFWRMVWELGSNCIVMLTKVFDFMrvmclqywpltkfqfreievettevktyshfvirtfkltrttpESIETRIVKHFHFTEWELDSFP-YISAFIE
.. .|||||..     |.|.||. .                                                ..| |  ||||||  .  | . |....
ld.dfwrmvfqenvttiamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllk

LRRRVRQfmEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMC
. . |.   .      |...||| | ||.|  ...|. .   |||  .| |..   . . ||..... ||| |||  . | .. 
fikevka..dfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-269 2e-07 24.7 In-house 5-85 (440) alignment 
Range on Protein: 187-269
Range on HMM: 5-85/440.0
PVDASKFVAYVQERRKKRIlFKGEYLMVNRSIDNNKCRCDVGSTMMdRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNS
|.  . |. |||. |. |  |. |. ..  .. .   .. . .  . .| | . | ||..||.|  . |  .|.||||||.|.
piivadfadyvqnnrrsra.fedewsllpsglsqpsdiaslpnnkv.knryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 188-486 1.3e-65 216.6 In-house 2-299 (318) alignment 
Range on Protein: 188-486
Range on HMM: 2-299/318.0
VDASKFVAYVQE-RRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKP
......   |.. |.. ..|.. || ...|| ..      . ..   .| | . |.||  || |  ..|.|.| ||||.|.. . |.|||. .||  .. 
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

MNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK-FQFREIEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPY-ISAFI
.. .||||||| .|  |||||.. .  .. . .|||  .  .. .. || .| ...|..|.|.||.|||  |. |.|.|. .|.|.|   . |   . ..
ie.DfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrt..eeeesrqvrqyhytsWpdegvpesgasll

ELRRRVRQfMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMHLLKERSS
.| |.|.. ..... . |.||||| | || | |.|.|. || .|. . .| |.. |.| . |. ..   .|| |||.|| ||...  . .. . |..|  
dlvrqvsk.aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

MY
  
el
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 188-474 7.5e-59 194.3 In-house 4-290 (305) alignment 
Range on Protein: 188-474
Range on HMM: 4-290/305.0
VDASKFVAYVQERRKKRI-LFKGEYLMVNRSidNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKP
.  ... ||..| |..    .. .| .. .   ....  .  ..   .| . .. ..| .|.||   . ...|.|||||||... | |.|.|.|.   . 
ialddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

MnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQ---FREIEVETTEVKTYSHFVIRTFKLTRTTPeSIETRIVKHFHFTEWELDSFPY-ISA
. |.|||...|   . ||||||. .  .  | |||| .| .   | |..|| .. ||.| ...| .|..     . |.| | ....|.|  .  |   ..
v.adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqfats

FIELRRRVRQFMEKNpVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPI
...| .||..  .|.  . |..||||.| ||.|.|.|.|  || .|| ...|.||. |.| ..|. .. . .||.|....| | . |    |
llslikrvqkdqkkd.kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsi
subfamily_CG7180_pd Subfamily CG7180 189-472 6.8e-129 423.7 In-house 1-295 (296) alignment 
Range on Protein: 189-472
Range on HMM: 1-295/296.0
DASKFVAYVQERRKKRILFKGEYLMVNRsIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMN
||.||...|..|||.|...|.|. ...| .....|...........|......|||||||.|...||.|.|.||||.||.|.|..|.|.||.|.......
dakkflklvdkrrkfrveyklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvd

aEFWRMVWELGSNCIVMLTKVFDFMRvMCLQYWPLT-KFQFREIEVETTEVKTYSHFVIRTFKLTRT--------TPESIETRIVKHFHFTEWEL-DSFP
 ||||.|.. .....|.|||.|||.. |...||| . |.|..||.||..|.|.|....|||||||..        .....||||||.|..||||| |..|
.efWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP

YI-SAFIELRRRVRQFMEKN---PVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQ
.. .|.||||||||...||.   |.|.|.||..|.||.|||..||.||||||..|....|.||..|||..|||.|...||.|..||.||.|||.||..
lstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
0051299 (Phosphotyrosine protein) phosphatases II 189-467 3e-71 235.5 In-house 6-286 (288) alignment 
Range on Protein: 189-467
Range on HMM: 6-286/288.0
DASKFVAYVQE-RRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpM
...... .|.. ...   ... |. .. . . ...... .    ...| |.| ||||..||.|  .||.|.| ||||||.. . .......||.   .  
sveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn.t

NAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWP-LTKFQFREIEVETTEVKTYSHFVIRTFKLTRT--TPESIETRIVKHFHFTEWELDSFPY-ISAF
 ..||||||| ....||||||.... |. | ||||  .. .. .| |.............||...|..  .  . |.|.|.|||.| |  ...|  ....
vedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

IELRRRVRQFMEknPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
... |.||....  . . |.|||||.| ||.|.|.|||  ||...|.| .|..|. |.| . ||... ..|||.|.||.| |..
ldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 191-490 1.2e-69 230.4 In-house 6-299 (317) alignment 
Range on Protein: 191-490
Range on HMM: 6-299/317.0
SKFVAYVQERRKkrILFKGEYLMVNRSIDNnKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAE
 ... ..  . .   ... |. .. . . .  ...      .|.| ||| ||||..||.|  ..||..| |||||||. . . .....||.   .   . 
llalldllksdf..talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn.tved

FWRMVWELGSNCIVMLTKVFDFMRVMCLQYWP-LTKFQFREIEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFP-YISAFIELRR
|||||||.|...|||||. ... |..| ||||  .. .. .. |.............||.... .  .. |.|.|.|||.| |  ...| ... .... .
FwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfle

RVRQFMEknPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMHLLKERSSMYKA
.||...|  . . |..||||.| ||.|.|.|..  ||...|.|..|..|  |.| . ||. . . |||.|.|..| | ...... .... || .  ....
avreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklli

KK
..
pl
subfamily_PTPN9_pd Subfamily PTPN9 191-465 3.9e-54 178.7 In-house 4-288 (297) alignment 
Range on Protein: 191-465
Range on HMM: 4-288/297.0
SKFVAYVQERRKKRIlfKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaE
...||||.|..|. .  . ||. . .   . .  .    . . .| | | | ||  || |...|.||.| ||||..|. . . ||.. ||    | .. .
eelvayvkekgkrGl..skeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs.d

FWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPL---TKFQFREIEVETTEVKTYSHFVIRTFKLTRTTPEsiETRIVKHFHFTEWELDSFPY-ISAFIEL
|||||||     ||| |.| .  |. | |||||   .  .| ...|.. ||........|........ |  |.| | || |. |     |   ......
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkte..esrkvthfqflsWPdyGvPssaaslldv

RRRVRQFM-----------EKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
.. ||.             . .| . |.||||| | ||.|.| .|| .|. ....|..| .|  |.| . | . |   |||.| |  . |
lekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 191-467 8e-49 161.1 In-house 5-283 (290) alignment 
Range on Protein: 191-467
Range on HMM: 5-283/290.0
SKFVAYV-QERRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDEN--SHYINASYVNSWLRDKAYVVTQAVRTKpM
.||  .| ... | .  |. .. |.. .  ...   ...|    .| . ....|| ||..| .| |...   .||||.|.. .  .|.|..||.  ..  
dkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn.t

NAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK-FQFREIEVETTEVKTYSHFVIRTFKLTRTTPEsIETRIVKHFHFTEWELDS-FPYISAFIE
 ..||...|.  . .|||||.. .  .| | |||| ..  .. |.... .. .|......|..... .. .  ....|.....| |. .   .  .. . 
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtill

LRRRVRQFMEKNPvEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
. ... . . |.  . ..|||||.. |||. |.|..  .. .|..|. | |.  |..   .| .. .|.|| .|.... ...
vieemyktqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPRG_pd Subfamily PTPRG 192-494 1.2e-52 173.9 In-house 5-316 (563) alignment 
Range on Protein: 192-494
Range on HMM: 5-316/563.0
KFVAYVQERRK-KRILFKGEYLMVNRSIDNNKCRCDVGSTM--MDRNPYPDTLPYDYNRVILPRIDGDENS-HYINASYVNSWLRDKAYVVTQAVRTKPM
.|. .| .      | |. |.  ... . ...  ..  .      .| | . ..||  || |  . | ...  ||||.|.. . . ||...||   .. .
efakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtf

NaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK-FQFREIEVETTEVKTYS-----HFVIRTFKLTRTTPeSIETRIVKHFHFTEWELDSFPYIS
.  ||||.||  .. |||.|.. . .|  | .|||  .  .. ...|  .| .. .     ..||. .|| ..     . . |...|.|.|   . |  |
d.dFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehs

AFiELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMHLLKE
.. .|   ...   ..    |.|||||.|.||.| ...||. |. ...  . . |. .|..   |..|. . |||.|....| ||.. . . .  . ..|
lp.vLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee

--RSSMYKAKKNREL
    . |  .. ...
lknctpyleqqykni
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 192-482 2.7e-51 169.4 In-house 10-294 (315) alignment 
Range on Protein: 192-482
Range on HMM: 10-294/315.0
KFVAYVQER-RKKRILFKGEYLMVNRSiDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAE
....|| ..    .  || .|  .    .    .    .   ..| | . ..||  || || .. |..|.|.||.... . . . |. .|.  .  .  .
qlityvaqkkastkngfkqdyesipgg.qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv.kd

FWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFREIEVETTEVKTYSHFVIRTFklTRTTPEsiETRIVKHFHFTEWELDSFP-YISAFIELRRR
|||.|.|     |||||.. .  . .. .|||  |  . .| |   . . .... .||.  . .  .  . | |  .|.| |     | |  ....| |.
fwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgd..nirevvqlhytswpdmgvpkytiplmnlirt

VRQFMEKNPveAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMHLLKER
|.|. ...   ...|||||.| ||.|.|..||| |. ..    .| ... . . . | ......||| |||..| |...|    |  .|  .|
vkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 193-470 4e-47 155.6 In-house 7-281 (287) alignment 
Range on Protein: 193-470
Range on HMM: 7-281/287.0
FVAYV-QERRKKRILFKGEYLMVNR-SIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPridgDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAE
|  .| ....| .  ||  . .... . ....   .. |   |.| . . |..| .||.|     .|.  ||||......  .||......  .. .  .
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfnta.rn

FWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK-FQFREIEVETTEVKTYSHFVIRTFKLTRTTPESiETRIVKHFHFTEWELDS--FPYISAFIELR
||.....   . ||||..  .  . .| |||| .|   . | ..| .. ........|........ .. ... || ...|.|.       . . .. . 
fWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkag.dkqqvkqyqitnWdstgkvtepqtillvie

RRVRQfmEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCN
.....  .. . ....|||||.. |||. |.| .  ..  |. | .| |.  |     .|. .  ||||.||.... | . . 
emykt..qrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
0039614 (Phosphotyrosine protein) phosphatases II 194-471 8.1e-68 224.4 In-house 21-293 (297) alignment 
Range on Protein: 194-471
Range on HMM: 21-293/297.0
VAYVQERRKKRILFKGEYLMVNRSIDNnkCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDG-DENSHYINASYVNSWLR-DKAYVVTQAVRTKpMNAEF
...  |..... |.. |. .. . ...  ...      .|.| |.| ||||..||.|  .|| |..| |||||||. . . ......||.  ..   . |
lllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.tvedF

WRMVWELGSNCIVMLTKVFDFMRvMCLQYWPLTKFQFREIEVETTEVKTYSHFVIRTFKLTRtTPESietRIVKHFHFTEWELDSFP-YISAFIELRRRV
||||||.|...|||||| ..  | .| |||| .  .. .. |....|........||...|. . ||   |.|.||..| |  .. | ... ..|. . |
wrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn.nges...rtvthfqytgwpdhgvppslellleflelv

RQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNV
|......| . |..||||.| ||.|.|.|..  ||...|.|..|..|  |.| . ||. . . .||.|.|..| | .....
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 194-464 3.1e-18 60.5 In-house 10-284 (305) alignment 
Range on Protein: 194-464
Range on HMM: 10-284/305.0
VAYVQER-RKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILpriDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFW
. .|..   |  . .. |.  ..|  | .| ..   .   ..| | |    | ||| |   .|    .|| | || .    | .. |||   |   |.||
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplek.tcadfw

RMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK---FQFRE----IEVETTEVKTYSHFVIRTFKLTRTT----PESIETRIVKHFHFTEWELDSFPYI-
 | ..   . | || .. .     ||.|..  .   ..|.|    | |     .|..       |.|.|         ..| |.|.|. .|     |   
ymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaad

SAFIELRRRVRqfmeknPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEY-AKTLVNSRPHLIDSVEQYMFIYEVLS
 | .||  . |      |   |.||||| | ||.|. . |.  |. .    ...  .   . . . |   |.. .||.|...|. 
lailellekar......pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvil
subfamily_Ptp69D_pd Subfamily Ptp69D 195-469 2.3e-58 192.8 In-house 12-288 (307) alignment 
Range on Protein: 195-469
Range on HMM: 12-288/307.0
AYVQERRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRtKPMNAEFWRM
|... .|.   ... || .....  . ...         .| |.|  ..| .||.|..| |.|.| |||||.....   | ... |.        .||||
alksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv.eatigDfWRm

VWELGSNCIVMLTKVFDFMRVMCLQYWP-LTKFQFREIEVETTEVKTYSHFVIRTFKLTRTT---PESIETRIVKHFHFTEWELDSFPYIS-AFIELRRR
..|  .. ||||... .  |  | .|||  .. |. .| |.. . .. |...||.......    .|  ..| |  .|.|.|.    |  . . ..| ..
iaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

VRQFMEKNpvEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMC
||.  ..|  ..|.|||||.|.|||| |.|||  |. .|.  ..| ||  | | . |. |..| |||.|.|  | .  . 
vrelykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRN_pd Subfamily PTPRN 195-467 1e-39 131.0 In-house 19-292 (297) alignment 
Range on Protein: 195-467
Range on HMM: 19-292/297.0
AYVQERRKKRILFKGEYLMV-NRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYV-NSWLRDKAYVVTQAVRTKPMnAEFW
.|...  |..  .. |.  . .   ... .       ....| . ..|||| .|| | .   .|.|.||||| . ..  |  ||. ||.  .. . |.||
syledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastv.adfw

RMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFRE-IEVETTEVKTY-SHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPYIS-AFIELRRR
.|||| |.  ||.||.. .     | .||| .  .  .  ||.    . .   ...|.| |     .. ||| |  |||  |.  . |  . ...|.||.
qmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknl..qtsetrtvtqfhflswpeegvPasaksllefrrk

VRQFMEKnpVEAPMVVHCSNGAGRSGAFLALDANLELMKK-TGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
| .        .|.|||||.||||.|.....|  |. ..|   ..|     . | . ||.|. . .|. |.. ...| |
vnksyrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 196-468 2.4e-41 136.6 In-house 10-280 (439) alignment 
Range on Protein: 196-468
Range on HMM: 10-280/439.0
YVQE-RRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDR--NPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVrTKPMNAEFW
.|..  ..|. .|| .. ..|    . .| . . .   |.  | | |  ..|. ||.|  | |   |||||| |.. .  || |. ||.  .|    .||
hvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgp.kkettddfw

RMVWELGSNCIVMLTKVFDFMRvmclqYWPLTK-FQFREIEVETTEVKTYSHFVIRTFKLTRTTPESIETRIVKHFHFTEWELDSFPYISAFI-ELRRRV
|.|.|  .  |||||.... ..     |||  .   . .| | .       ..||| ||.      .   | | .||.. |     |  .... .. | .
rlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrai

RQFMEKNpVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
    .|.    |.||||| | ||.|. .|||  || .|   ..|     | | . | ...... ||.|||. . | ..
nsandke.eygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
0047943 (Phosphotyrosine protein) phosphatases II 197-466 6e-69 227.9 In-house 4-271 (273) alignment 
Range on Protein: 197-466
Range on HMM: 4-271/273.0
VQERRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILpridGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVW
. |... . |.. |. .. . ... .... .    .|.| |.| ||||..||.|    ||..|.|||||||. . . .....||.   .   ..||||||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpn.tvedfwrmvw

ELGSNCIVMLTKVFDFMRVMCLQYWPLT----KFQFREIEVETTEVKTYSHFVIRTFKLTRTTPESieTRIVKHFHFTEWELDSFP-YISAFIELRRRVR
| ....|||||....  |. | |||||.    . .. .. |......|......||..||..  .   .|.|.|||.|.|  .. | ... ..|. . ||
eqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvr

QFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEA
...|..| . |.|||||.| ||.|.|.|||  |....|.|..|..|. | | . ||. . ..|||.|.||.| | 
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 197-468 1.5e-65 217.3 In-house 19-305 (307) alignment 
Range on Protein: 197-468
Range on HMM: 19-305/307.0
VQERRKKRILFKGEYLMVNRSID--NNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGD-ENSHYINASYV--------NSWLRDKAYVVTQAVRTK
 .. .. . ... |. ....  .  ......      .|.| |.| ||||..||.|  .||. |.|.|||||||        ... .......||.   .
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

pMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT--KFQFREIEVETTEVKTYSHFVIRTFKLTRTtPESIETRIVKHFHFTEWELDSFP-YISA
   ..||||.||.|...|||||. ... |..| ||||..  ....... |.............||...|..  .. |.|.|.|||.|.|  .. | ... 
.tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfee

FIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQ---LDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
.... ..||...|..| . |..|||| | ||.|.|.|..  |....|.|    .|..|  |.| . ||. . . |||.|.||.| | ..
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0050432 (Phosphotyrosine protein) phosphatases II 198-471 1.3e-71 236.8 In-house 35-303 (308) alignment 
Range on Protein: 198-471
Range on HMM: 35-303/308.0
QERRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILpridgDENSHYINASYVNSW--LRDKAYVVTQAVRTKpMNAEFWRMV
 |. . . |.. |.  ...  .......      .|.| |.| ||||..||.|     ||.|.|||||||. .   .......||.   .   . |||||
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpn.tvedFwrmv

WELGSNCIVMLTKVFDFMRVMCLQYWPL----TKFQFREIEVETTEVKTYSHFVIRTFKLTRTTPEsiETRIVKHFHFTEWELDSFPY-ISAFIELRRRV
|| ....|||||| ..  |. | |||||    .  ..  . |.............||..|| .  .  |.|.|.|||.| |. .. |  ....... ..|
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelv

RQFMeKNpveAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNV
|... ..    |.|||||.| ||.|.|.|||  ||...|.| .|.||. |.|   ||. . ..|||.|.|..| | ... .
rksl.pg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0043336 (Phosphotyrosine protein) phosphatases II 198-464 1.2e-65 217.1 In-house 13-274 (278) alignment 
Range on Protein: 198-464
Range on HMM: 13-274/278.0
QERRKKRILFKGEYLMVNRSIDnNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWE
.  .. . |.. |.  ...    . ...      .|.| |.| ||||..||.|  ..||..| |||||||. . . .....||.  ..   . |||||||
elllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.tvedFwrmvwe

LGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFREIEVETTEVKTYSHFVIRTFKLTRTTPE-SietRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFME
||...|||||. ... || | |||| . ... .. |.............||...|..    |   |.| |.|.. |  ...|  .| .... ..||...|
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslsllldflkavreale

knPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLS
  . . |..||||.| ||.|.|.||.  ||...|.| .|..|  |.| . ||. . . .||.|.||.| 
..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0036941 (Phosphotyrosine protein) phosphatases II 200-472 4.4e-70 231.7 In-house 8-282 (297) alignment 
Range on Protein: 200-472
Range on HMM: 8-282/297.0
RRKKRILFKGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILpridGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELG
. . . |.. |.  . . . . ....      ...| |.| ||||..||.|    .||.| |||||||. . .......||.   .   ..|||||||..
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpn.tvedFWrmvweqn

SNCIVMLTKVFDFMRVMCLQYWPLT---KFQFREIEVETTEVKT--YSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQF
...|||||....  |..| |||||.    ... .. |....|..  ......||...| |  .. |.|.|.|||.| |  .. |  .. .... ..||..
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrkv

MEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMK---KTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQ
... | . |..||||.| ||||.|.|.|  |....   |.|..|..|. |.| . ||. . ..|||.|.||.| | .... .
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 201-470 5.2e-65 214.6 In-house 23-293 (298) alignment 
Range on Protein: 201-470
Range on HMM: 23-293/298.0
RKKRILFKGEYLMVNRS---IDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWE
.|| . .. |.  .|.    |.... .    ..  ..| |.| ...|. ||.| ..|.||.| |||||..... . .|...|||  |. . ..|||||.|
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetv.edFWrmvte

LGSNCIVMLTKVFDFMRVMCLQYWPL-TKFQFREIEVETTEVKTYSHFVIRTFKLTRTTPEsiETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQfME
  ...|||||.. .  .. . .|||   | .. ||.|.  . .... ...|..|..... |  ..| |...|||.|   . | . .. ..|.|.||. ..
edigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvra.sq

KNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCN
..  ..|..|.||.| ||||.| |.|. || .||   .| |.. |.| ..||..... |||.||||.  ||. . 
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 201-465 1.6e-53 176.6 In-house 17-277 (288) alignment 
Range on Protein: 201-465
Range on HMM: 17-277/288.0
RKKRILFKGEYLMVnRSIDNNKCRC-DVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMVWELG
...|  |. ||  .  .....|  .    .   ..| |.. ||||..|| |   .  ... ||||||...  ..|.|. ||.  .. .| .||..|.|  
arnrtgfseeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvn.dfWelvyenk

SNCIVMLTKVFDFMRVMCLQYWPLTKF--QFREIEVETTEVKTYSHFVIRTFKLTRTTpesiETRIVKHFHFTEWELDSFPYIS-AFIELRRRVRQFMEK
.. |||||.. .  .  | .||| ..   .. ...|. .|.|.  .|| |.. | ...    . . ....... |  .. |  .  ..||.| | .  ..
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk....teleitqyqylaWpdhgvPeskapllellrqvkvanqa

NpvEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
.    |..||||.| ||.| |.|||| .. .... ..| ..  . | ..|. |.. ..||.|||||| .
d..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 202-489 4.1e-68 224.8 In-house 20-305 (319) alignment 
Range on Protein: 202-489
Range on HMM: 20-305/319.0
KKRILFKGEYLMVNRSIDNNKCRCDvGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMVWELGSN
.   |.. |. ... . ...   ..      ..| |.. |.||  ||.|. .|| |.| |||||..... . .... |||   . .. .||||||| .| 
tgetllekefkllkeavndtfdsas.keenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentie.dfWrmvWeeess

CIVMLTKVFDFMRVMCLQYWPLTK-FQFREIEVETTEVKTYSHFVIRTFKLtRTTPESIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKnPV
..|||||. . ..| . .||| ..  .. .. |.  | .  ....|| .|| ..  . .||| ||||..|||  .  | .  . ..| .|.|. .|| . 
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tq

EAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMHLLKERSSMYKAK
. |.|||||.|.|| |.|..||| || .|. | || |.....|   |. ...  ||| ||||.| ||| .    ||.  |..|    . |
sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaek
subfamily_PTPRK_pd Subfamily PTPRK 207-477 6.4e-68 223.9 In-house 24-287 (314) alignment 
Range on Protein: 207-477
Range on HMM: 24-287/314.0
FKGEYLMVNRSIDNNKCrcdvgSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRtKPMNAEFWRMVWELGSNCIVML
|| ||  .    |  |          ..| . | |.||  ||.|  |||| .| ||||....|. | .|..|||    . . ..|||.|.. .. .||||
fkeeyeslfegwdaakk.....denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPl.qetvkdfWrlvydencasivml

TKVFDFMRVMCLQYWPLTKFQFREIEVETTEVKTYSHFVIRTFKLTRTTPESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQFMEKnpVEAPMVV
|.. . .|| ||.|||    .. .|.||  |... . .|.|.|......    |.|.|..|.|. |     |.   ....| ||| .  |.   . ..||
telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivv

HCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMH
|||.||||.|.|.|.|  |..... | .| |. .||| .... ...  |||.|||.|. ||..|    | . 
hCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 207-470 7.5e-36 118.4 In-house 17-296 (301) alignment 
Range on Protein: 207-470
Range on HMM: 17-296/301.0
FKGEYLMVNRSIDnNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDG--DENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIV
|. .|  ...  | ..|   . ..    | . .. .|| ||.||         . .||||||...  . |.....|.   | . ..|||..|.     ||
feeqykelkeged.ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktl.vdfWrliwqekpvsiv

MLTKVFDFMRVMCLQYWPL---TKFQFREIEVETTEVKTYSHFVIRTFKLTRTTPE---SI----------ETRIVKHFHFTEWELDSF-PYISAFIELR
|.|.  . ..  | ||||    .. .| ...|. .. ..|  |||| .... .      .|          ... |  .. |.|  |   .     ..  
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

RRVRqFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCN
  |    .. .  .|.|||||.. .||| . ...  ||  |  |  | |.  |..  |.|  .   |||..||.|... ...|
ddvi.hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqln
DSPc_SM00195 208-467 5.6e-64 211.4 In-house 3-262 (263) alignment 
Range on Protein: 208-467
Range on HMM: 3-262/263.0
KGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRtKPMNAEFWRMVWELGSNCIVMLT
| |.  ...|  ......   .  ...| | . |||| .||.|......|.| ||||.|..   ..|.|..||.   .   ..||||||| ....|||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlt

KVFDFMRVMCLQYWPLT---KFQFREIEVETTEVKTYS-HFVIRTFKLTRTTPesIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNpvEAP
. ..  .  | .||| .   | .| .|.|...||.... ....||..|| ...   ||| |.......|.  . |   . ..|| | |..  ...  ..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

MVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
.|||||.| ||.|.|...|  |. .... ..|.||  | | ..||..... |||.||||.. |..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 208-467 5.6e-64 211.4 In-house 3-262 (263) alignment 
Range on Protein: 208-467
Range on HMM: 3-262/263.0
KGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRtKPMNAEFWRMVWELGSNCIVMLT
| |.  ...|  ......   .  ...| | . |||| .||.|......|.| ||||.|..   ..|.|..||.   .   ..||||||| ....|||||
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlt

KVFDFMRVMCLQYWPLT---KFQFREIEVETTEVKTYS-HFVIRTFKLTRTTPesIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNpvEAP
. ..  .  | .||| .   | .| .|.|...||.... ....||..|| ...   ||| |.......|.  . |   . ..|| | |..  ...  ..|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgp

MVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
.|||||.| ||.|.|...|  |. .... ..|.||  | | ..||..... |||.||||.. |..
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_ptpA1_pd Subfamily ptpA1 208-419 1.1e-20 68.8 In-house 24-248 (418) alignment 
Range on Protein: 208-419
Range on HMM: 24-248/418.0
KGEYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLrDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLT
| |. ... |.  ..           .| | . || .. || | .|.  | | |||| |..     | ...||    . . |.|||||||     ||||.
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpnti.adfwrmvwenrcriivmls

KVFDFMRVMCLQYWPL--TKFQFREIEVETTEVKTYSHFVIRTFK------LTR---TTPESiETRIVKHFHFTEWELDSFP-----YISAFIELRRRVR
.  .  |. | .|||      ||         . |||  ..   .      .||    | |  ||| . ....  |     |     .   .  .  |  
resencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg.etrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

QFMEKNPVEAPMVVHCSNGAGRSGAFLA
| .  .  . |..|||| | ||.|.| .
qiipssdrnvpiivhcsagvgrtgtfct
0046845 (Phosphotyrosine protein) phosphatases II 209-471 4.9e-69 228.2 In-house 4-278 (284) alignment 
Range on Protein: 209-471
Range on HMM: 4-278/284.0
GEYLMVNRSIDNN--KCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGD-ENSHYINASYVNSW-----LRDKAYVVTQAVRTKpMNAEFWRMVWELGS
 |. ....   .   .... .    ...| |.| ||||..||.| ..||| |.|.|||||||. .      . |....||.   .   ..||||||| ..
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvweqnv

NCIVMLTKVFDFMRVMCLQYWPLT--KFQFREIEVETTEVKTYSHFVIRTFKLTRTTPESiETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQFMEKN
..|||||. ... |..| |||||.  .... .. |.............||..||.. ... |.|.|.|||.|.|  .. |  .. ..|. | ||...|..
rvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytg.esrtvthfhytswpdhgvppspedlleflrlvrellenl

PVEAPMVVHCSNGAGRSGAFLALDANLELMKKTG---QLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNV
| . |.|||||.| ||.|.|.|||  ||...|.|    .|..|. | | . ||. . ..|||.|.||.| |.... .
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0045098 (Phosphotyrosine protein) phosphatases II 210-470 2.7e-55 183.1 In-house 12-275 (278) alignment 
Range on Protein: 210-470
Range on HMM: 12-275/278.0
EYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVIlpridgdensHYINASYVNSWlrDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKV
|.  . .  ..... . .    .|.| |.| ||||..||.           ||||||....  .|....||.  ..   | ||||.||||...|||||..
efefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgP.lpstvadfwrmlwelgitvivmltel

FDFMRVMCLQYWPLTK-FQFREIEVETTEVKTYSHFVIRTFKLTRT--TPESIETRIVKHFHFTEWELDSFPYIS---AFIELRRRVRQFME--------
..  |. | ||||  . ... ...|.............||...| .   .|..|.| |.|.|.. |.  . |  .    |.|| ...|....        
velgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

---KNPVEAPMVVHCSNGAGRSGAFLALDANLELMkkTGQLDFFEYAKTLVNSRPH-LIDSVEQYMFIYEVLSEAVMCN
    .. . |..|||| | ||.|.. |..  |||.   |..|..|. |.| . ||.  . . |||.|.||.| | ....
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN14_pd Subfamily PTPN14 210-464 2.5e-38 126.8 In-house 28-293 (300) alignment 
Range on Protein: 210-464
Range on HMM: 28-293/300.0
EYLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDeNSHYINASYVNSWL--RDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLT
||  . .   . .. .       ..| ..| |||. ||| |     . .. ||||| ..  .  ... |.|.|.   . .  .||.|||| | . |||||
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltv.qdfWqmvWeqgvqlivmlt

KVFDFMRVMCLQYWPLT-----KFQFREIEVETTEVKTYSHFVirTFKLTRTTPESIETRIVKHFHFTEWELDSFP--------YISAFIELRRRVRQFM
.  .  .  ...|.| .     . .| . .| |  ... . ..  | .|.     | | | | |. .|.|  .  |        |.  .  .||.. . .
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvi..ttglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

EKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLS
| . .. |..||||.|.||.|  .  |  .. ...  ..|  .  ..| . | .|.... || |.|.|| 
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_PTPN1_pd Subfamily PTPN1 211-469 9.3e-43 141.0 In-house 12-273 (290) alignment 
Range on Protein: 211-469
Range on HMM: 12-273/290.0
YLMVNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGdensHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVF
|| ...  .. ..|     .  ..| | |  |||. |..| | |     .||||| |.    .. |..||   .. . . ||.||||  | ..||| || 
yldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntv.dhfWqmvWeqkskavvmlnkvv

DFMRVMCLQYWPLT----KFQFR--EIEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQFMEKNPVEAPM
.  .. | ||||      ....   ...|.  . ...|....|...|.    .. ||| . |||.| |   . |   .||...  .||.    ..   | 
ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl..ktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

VVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRP---HLIDSVEQYMFIYEVLSEAVMC
|.||| | ||||.|  .|. | |..|...|.  .  |.|.. |     ||   .|  | |  . | . .
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 211-467 4.1e-11 37.1 In-house 25-276 (312) alignment 
Range on Protein: 211-467
Range on HMM: 25-276/312.0
YLMVNRSIDNNKCRcdVGSTMMDRNPYPDTLPYDYNRVILpriDGDENsHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVF
|  |   . . .|       . | | ||.   .|  |  |    ||||  || | .|.   . . .|.||.   .   . ||...  ||| .|..|. . 
ykavgnivsdsect..aflkfkdlnrypniqcwdrgrftl...agden.fyihanfvkictkperfvctqgplen.tcthfwqlalslgstsiillcgfv

DFMRVMCLQYWPLtKFQFREIEV------ETTEV----KTYSHFVIRTFKLTRTTpESIETRiVKHFHFTEWELDSFPYiSafIELRRRVRQFMEKNpvE
.     | .|       | ..|         ||.    |.  .   | .|.   .    |.. ..|. .. |    .|  |   .   |.   . |.   
edgsekcakyisd.ivgfvdledhrvyteycteieiggkskdkithrvlkvvvka.tgqesk.lnhyqwaswpdhgmpd.s..cdtalrllsavkkd..k

APMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
 |.. ||| | ||.|..  ... .  ...  . .  .    | . |   .  . ||..   .. | .
kpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_PTPN23_pd Subfamily PTPN23 214-466 2.5e-40 133.1 In-house 26-279 (288) alignment 
Range on Protein: 214-466
Range on HMM: 26-279/288.0
VNRSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPridgDENSHYINASYVNSWLRD-KAYVVTQAVRTkPMNAEFWRMVWELGSNCIVMLTKVFDF
 .   ...|  . .  .. ..| . | |||| ||| |     ...  |||||.|..       ...||| .  .  ..||.||.|  |. ||||..  . 
qkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlq.stlnDFWlmvyeqkssviVmllskeel

MRVMCLQYWPLTK---FQFREIEVETTEVKTYSHFVIRTFKLTRTTPEsiETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQ--FMEKNPVEAPMVVH
 .  . .|||  |    .| ...|   .|.. ...| |..||.   ..  ... |.| ..|.|     |   . ....   |..    .......|.|||
gkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldad..avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvh

CSNGAGRSGAFLA-LDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEA
|| | ||.|.|     |  || |. | ||  .  ..| . | . .  .||. | ||.  ||
CsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 216-468 1.5e-38 127.3 In-house 18-260 (267) alignment 
Range on Protein: 216-468
Range on HMM: 18-260/267.0
RSIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDenshYINASYVNSWLRDKAYVVTQaVRTKPMNAEFWRMVWELGSNCIVMLTKVFDfmRv
 | ..... . ...   .|| . |.|||| .||||   . .    |||||||... . .|..|||    |   ..|. .. . .   ||.|||||     
isdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtq.dplkntitdfltvihdqkvpvivlltkvft..d.

MCLQYWPLT---KFQFREIEVETTEVKTYSHFVIRTFKLTRtTPESIETriVKHFHFTEWELD--SFPYISAFIELRRRvRQFMEKnpvEAPMVVHCSNG
   ..||       ..... || .  |    . | |..|     ||     |  ... .|...    ||.  .. .  .  |. .    . |.||.||.|
nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkf.knesahn..vtlyyykkwnintnnkpylkplfgilak.nqleng...nrPlvvacsdG

AGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
 ||||.|| .|. || .|. | .| |.. . . . |. |.|. |.|..|.|.|.|   
vGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 217-471 8.3e-40 131.4 In-house 19-270 (283) alignment 
Range on Protein: 217-471
Range on HMM: 19-270/283.0
SIDNNKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGdensHYINASYVN---SWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFM
|. . .. ... .     | . . .|.| .|| |         .||||...    |  .|| |...|.   .    .||.||..    .||||||. . .
svpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldr.tvvdfWkmvfdekitaivmltklqedl

RVMCLQYWPLT-KFQFREIEVETTEVKTYSHFVIRTFKLTRTtPESIETRIVKHFHFTEW-ELDSFPYISAFIELRRrVRQFMEKNPvEAPMVVHCSNGA
|. | ||||     .. |  |   .  |   |.|. . |      . .| .. |. . .| | .  . | ... . . |.    ... ..|.|||||.| 
rikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.ssakstlllahyqvidWleygeqaiinslvkfnk.vislqtesk.kgPivvhCstgi

GRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNV
||...|.|. | .. ..    .| |.  | . . |. .. . .||....|.  |  .|  
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 217-464 5.3e-19 62.7 In-house 39-282 (302) alignment 
Range on Protein: 217-464
Range on HMM: 39-282/302.0
SIDNNKcrCDVGSTMMDRNPYPDTLPYDYNRVILPridgDENSHYINASYVNSWLRDKAYVVTQAVRTKP--MNAEFWRMVWELGSNCIVMLTKVFDFMR
 .| .|  | .    ...|  .|.  .| |.|.|.     |. .|.||| |.     .  ...|   ..     .||||||..     .|.| .  .  .
kvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk

vMCLQYWPLTKF---QFREIEVETTEVKTYSHFViRTFKLTrTTPES-IETRIVKHFHFTEWELDSFPyISAFIELRRRVRQFMEKNPVEAPMVVHCSNG
    ...|..     .. .. | .  |.  .  .   . .    ||   .. ...  ..| |. .. | ..     .  .  |..| ......|.   ||
.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviE.vlPegcsnsvlanvyvltnWkqkkvp.vkyaeliktaakvfakkikadentvivSknG

AGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLS
||| ||||.| . .| ..|  .    | .|.. . ||. .||..||...| .| 
aGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_PTPRA_pd Subfamily PTPRA 221-480 1.1e-58 193.7 In-house 48-313 (330) alignment 
Range on Protein: 221-480
Range on HMM: 48-313/330.0
NKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQY
. .        ...| ... ||||..||||. ..| |.| |||||... . . . .. .|  ... .. .||||.||  |  |||||.. .  .  | ||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetve.dfwrmiweqksativmltelkerkeekcaqy

WPLT-KFQFREIEVETTEVKTYSHFVIRTFKLTrTTPESI---ETRIVKHFHFTEWELDSFPYIS-AFIELRRRVRQFMEKNPVeaPMVVHCSNGAGRSG
||    . . .| ||  ...   .. .| | ..   |..    ..|.|. |||| |     |  .   ..| ..|..  ...    |.||||| |.||.|
wPdeGlvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivvhcsaGvGrtG

AFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIE-----MHLLK
.|..||| || .|  ...| ||  | | . ||... . ||| |||.|| |  .     ..      || |
tfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 221-468 6.6e-50 164.8 In-house 31-277 (281) alignment 
Range on Protein: 221-468
Range on HMM: 31-277/281.0
NKCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQY
|  .       . .| | .   ||  || . . . ..|. ||||..|...  .|.|..||.   . .. .||.||||   . |||.|.  .  .. | .|
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslv.afWqmvweqkvsaivmvtreieagklkChrY

WPLTK--FQFREIEVETTEVKTYSHFVIRTFKLTRttpESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQFMEKNPvEAPMVVHCSNGAGRSGAF
||  .   .. .. |..|. .. .... |.|||.|   || ||| |.....| |     |   ....| |. |... ||.  .||.|.||| | ||.|..
WPddnselkygdvtvkstaeeekatyierkfkler...esgetreveqlaytaWPdhGvPattkellefrkevlkltekkt.kaplvihCsaGvGrtGty

LALDANLELM-KKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
.|||  .. . ... .||  .  . | ..|  .. .| || |.| .. .|..
ialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 221-336 7.3e-13 43.0 In-house 37-165 (350) alignment 
Range on Protein: 221-336
Range on HMM: 37-165/350.0
NKCRCDVGSTMMDRNPYPDTLPYDYNRVILP----RIDG----DENSHYINASYVNSW----L--RDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVML
|      |  .. .| | . |||. .||.|.      |.     . . ||||.|..          |  |. |||   . .. .|.... . . . |..|
nDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvd.dfykvillnkvkvilsl

TKVFDFMRVMCLQYWPLTKFQFREIEVETT
|. ... .  | .||.  ...   . .. .
tsdvelnlekcyrYWqegsydditvklask
0040439 (Phosphotyrosine protein) phosphatases II 222-468 7.3e-61 201.2 In-house 2-247 (249) alignment 
Range on Protein: 222-468
Range on HMM: 2-247/249.0
KCRCDVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYW
....      .|.| ||| ||||..||.|  ..| . | ||||||.. . . .....||.  .. . . ||||.||||...|||||. . . |. | |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-LTKFQFREIEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLA
|  . ... .. |....|........||..||..  .  |.| |.|...| |  .. | ... .... ..||...|..| . |..||||.| ||.|.|.|
plggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

LDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
..  ||...|....|..|. |.| . ||. . . |||.|.||.| | ..
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 222-468 1.6e-25 84.8 In-house 32-278 (307) alignment 
Range on Protein: 222-468
Range on HMM: 32-278/307.0
KCRCDVGSTMMDRNPYPDTLPYDYNRVILpRIDGDeNSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYW
    .  |.  |.| | |    | .|... ..||   | || | |.   .. | ....|  . .    .|| |. .   ....|| || .  .. | |||
gvtveafsantdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplen.tqysfwamaiqekvesvimlckvielakikceqyw

PLTKFQFR-------EIEVETTEVKTYSHF--VIRTFKLtrTTPESIETRIVKHFHFTEWELDSFPYIS-AFIELRRRVRQfmEKNPVeapmVVHCSNGA
|| . |          | |.   .|. .    .|   .|      . ..| ..|. ...|     | |  . |.|   ||   ..|||    ||||| | 
pleegqklvfgeapntisvanlgakklapdedlinvttl..kvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..dtnpv....vvhcsaGv

GRSGAFLALDANLE-LMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
||||. .|.    . ...     |  .  . | . |.. | .  ||.... || |  .
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_PTPN13_pd Subfamily PTPN13 224-466 2.9e-43 143.1 In-house 28-268 (273) alignment 
Range on Protein: 224-466
Range on HMM: 28-268/273.0
RCDVGST--MMDRNPYPDTLPYDYNRVILpridGDENShYINASYVNSWLRDKAYVVTQAVRTKPM-NAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQY
.|.|| .   .|.| | . ||||  ||.|    ||| . |||||...  . .. |.   .    |   ..||.||||  .. |.|.|.  .  .| | .|
tcevgkkkenkdknryrnvlPydetrvkl....gdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchry

WPLTK---FQFRE-IEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPYISA-FIELRRRVRQFMEknpVEAPMVVHCSNGAGRSG
|| .|    . .. .|||  .|. .. ||.|..... .  || |.| | |..|..|   . |  .| .... ..||.. .    ..|.||||| | ||||
wPesknkklkvsnrlevellkvqkldgfvvralavkds..esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPivvhcsaGiGrsG

AFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEA
.....|. |.|...  ..|  |  ..| . |  .. . .||.|.|... |.
tlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPN12_pd Subfamily PTPN12 226-472 5.2e-50 164.9 In-house 33-282 (290) alignment 
Range on Protein: 226-472
Range on HMM: 33-282/290.0
DVGS--TMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPL
..|.  . . .| | | ||||..|| | .|...|.| ||||....    ...|. .|.  .| .. .||||.||   . .||. ....  .  | .||| 
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktld.dfWrmiweknveivvmaCrevelgkkkCerYWpe

T---KFQFREIEVETTEVKTYS-HFVIRTFKLTRTtpesIETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQFMEKNpvEAPMVVHCSNGAGRSGAFL
.   . .| |.||...| |. .  |.|||.|...      |.|.|. ||.|.|     |  ..  .|| . ||.. |..  .||.||||| | || |. .
egeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqese..daPlvvhCsaGvGrtGtii

ALDANLELMKKTG---QLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQ
|.|   ||.|.     .|| |.   .| . |. |. . ||| ..|. . | |  ...
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_CG42327_pd Subfamily CG42327 226-375 1.1e-18 62.0 In-house 23-174 (319) alignment 
Range on Protein: 226-375
Range on HMM: 23-174/319.0
DVGSTMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK
.|  |  |.... ...|    ||.|.||  |....|..||||      ... ..  |  .   ..|||.|||  |  || ||....    .| .|.|  .
evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

-----FQFREIEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFtEWELD
       . .| |   . ..  ...| |. | |   .  |.| . |. . .|   
tldntslyGdilvtlkgrevkdryaistlllkrv..dkeesrelthywy.kwlea
subfamily_PTPN3_pd Subfamily PTPN3 229-466 5.1e-44 145.3 In-house 39-274 (280) alignment 
Range on Protein: 229-466
Range on HMM: 39-274/280.0
STMMDRNPYPDTLPYDYNRVILPridgDENSHYINASYVNSWLRD----KAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT
.  ...| | | ||||  ||.|     .... ||||.|||  .      . |..||   .|   ..||.||||  |. ||||| . .  || | |||| |
penlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlak.tatdfWqmvweqksslivmlttlverGrvkChqyWPet

--KFQFREIEVETTEVKTYSHFVIRTFKLTRTTpeSIETRIVKHFHFTEWELDSFPYIS-AFIELRRRVRQFmeKNPVEAPMVVHCSNGAGRSGAFLALD
  .... |..|. .. .. . .|.| . |....  . | | . .. ...|   . |  |  |.|. .|||.   ..  | |.||||| | ||.| ...|.
edeleygefsvkcekedetksyvlrelvlkdke..tkeerkilqlqylaWpdhgvPddsadflefvervrkl..rsgkeePvvvhCsaGigrtGvlille

ANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEA
  | |. .. ..   .  .|. . |  |.....|| |. | . ..
talalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 229-462 1.4e-15 51.7 In-house 50-285 (310) alignment 
Range on Protein: 229-462
Range on HMM: 50-285/310.0
STMMDRNPYPDTLPYDYNRVILpRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQF
   | .| | | .  |  || | .||      || | ||..    ......|    . .  .||||...  .. |..| || .  |  |. |||      
kkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhti.idfwrmifqeraesilllckvgeegrpkcvgywpslgvte

REIEVETTEVK-TYSHFVIRTFKLTRT---TPESIETRIVKHFHFTEWELDSFPYISAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANL
    .  |..  .   | |  . .|      |   .   .|..  .      .|      |    | | .  .    | ||||| | .| .. .||. ..
tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklki

ELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEV
. ...  ..|. |    | .||   |..  ||..|  |
dkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 230-476 2.1e-47 156.8 In-house 47-297 (325) alignment 
Range on Protein: 230-476
Range on HMM: 47-297/325.0
TMMDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMV--WElgsNCIVMLTKVFDFMRVMCLQYWPLT---
  ...| ... ...| .||.|   . | .| ||||||...  . . .. .||  |. .| ..||.|  |.     .|... ..|     | .|||     
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin.dlWrlvldWr...csvvvvlneldlgkdrcavywpkemgk

KFQFREIEVETTEVKTYSHFVIRTFKLTRttPESIETRIVKHFHFTEWE-LDSFPYISAFIELRRRVRQFMEKNPV----EAPMVVHCSNGAGRSGAFLA
  .|  .||.   ....| .| | ... .  ..  ||| || |..  |. .    . ...| . . | .  |.        .|..||||.| ||.|.|..
sktfGglevklrtieeisdyvhrvldvkq..vkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

LDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEM
| . |. . .  ..| |.. | | . || ....|.||..||| | ||.|.    . .
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpv
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 230-465 2.4e-41 136.6 In-house 27-266 (274) alignment 
Range on Protein: 230-465
Range on HMM: 27-266/274.0
TMMDRNPYPDTLPYDYNRVILPRIDG-DENSHYINASYVNSWL-RDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK-F
    .| | . || .  ||.| . .. ||.|.|||| |.     ..|||| ||   .. . |.||||...  .. ||||||. .  .  | .|.| .. .
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntv.adfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----QFREIEVETTEVKTYSHFVIRTFKLTRTTPesieTRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNPVE-APMVVHCSNGAGRSGAFLAL
    .. ..|........  .. .|.. |  ..     .| |||. .|.|     |  ......| . |..  |..  . ||.||||| | || |.|.| 
eiserygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

DANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
.  .  ..... .| ..    |   |  .... ||| .|...|..
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 230-463 2.5e-27 90.3 In-house 55-279 (290) alignment 
Range on Protein: 230-463
Range on HMM: 55-279/290.0
TMMDRNPYPDTLPYDYNRVILPriDGDeNSHYINASYVNSwlRDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK---F
| . .| | |    |  ||||   ||  .  |. | ||.    .  ...||   .|    ..|||| . .   |||| ....  .  | ||.| ..   .
tefkknrykdvvcndktrvilk..dGy.dGdyvhanyvkG..lkamfiltqGa.lkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

QFREIEVETTEVKTYSHFVIRTfKLTRTTPESIETRIVKHFHFTEWELDSFPYiSAFIeLRRRVRQFmEKnpVEAPMVVHCSNGAGRSGAFLALDANLEL
 | || |  .| ..    .|.   |.    .|    ..||..   |   | .  |..  | | .|    |  .  |.||||| | ||.|.| |... |..
tfGeitvlcseeddkdaniikk.tlsvrdkdsGkehklkhlkikswpdksval.stla.llrtlril.rk..asGpvvvhcsaGiGrtGtfvaievglqi

MKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVL
. .  .||  .  ..| |||   ..   ||. . |.|
lldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 230-468 2.7e-17 57.6 In-house 34-271 (285) alignment 
Range on Protein: 230-468
Range on HMM: 34-271/285.0
TMMDRNPYPDTLPYDYNRVILPRIDGDenshYINASYVNSWLRDKA-YVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT---K
.  | | | |    .  ||.|   | |    || ||..    .|.. |. ||    .   ..||.|...     ..||  .|.     |  |.|      
anpdlnryadvrcieetrvvlknhdrd....yihaswmrmpgkdqstyittqgplpe.tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

FQFREIEVETTEVKT--YSHFVIRTFKLTRTTPESIETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQFmekNPVEAPMVVHCSNGAGRSGAFLALDA
 .| . |.  ||.|    .  .. .. .. |   | |   ..| .   |  .  |     .||| . |..    || | |..|||| | ||. .|. .| 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv...npkekpicvhcsagvgrtatfvgidy

NLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM
    . .  ......  . .   | . ..|  |..|.| || | ..
atirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
subfamily_PTPN6_pd Subfamily PTPN6 231-467 3.9e-45 149.2 In-house 54-297 (306) alignment 
Range on Protein: 231-467
Range on HMM: 54-297/306.0
MMDRNPYPDTLPYDYNRVILPrIDGDENSHYINASYVNSWL--RDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT--KF
 . .| |   ||.| .||||   ..  .| ||||.|... .   ||.|. ||   .. .. .||||||.  |. |||.||  .  . .| .||| .  | 
nkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvs.dFWrmvwqensrvivmttkevErgkekCarYWPdeeeke

QFREIEVETTEVKTYSHFVIRTFKLTRTTpESIETRIVKHFHFTEWELDSFPYISAFI-ELRRRVRQFMEKNP--VEAPMVVHCSNGAGRSGAFLALDAN
.. .|.|.... |. .....|........ .. |.| | ..||..|   . |     . .. . |.. .|.     . |.|||||.| || |.|. .|. 
eyGkisvtnvseksladYilRelsvskkk.kkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

LELMKKTG---QLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
|.|..|.|   ..|  .  |.. . |  |.   .|| |.|..... .
lkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
0049772 (Phosphotyrosine protein) phosphatases II 231-465 3.4e-29 98.0 In-house 46-278 (314) alignment 
Range on Protein: 231-465
Range on HMM: 46-278/314.0
MMDRNPYPDTLPYDyNRVILPRIDGDEnSHYINASYVNSWlrdKAYVVTQAVrTKPMNAEF----------WRMV--WELGSNCIVM-------------
 .|.| |.| ||.| ||||||. ...  | |||||||..    .....||.  ..     |          ||||  ..| .  |||             
nrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LTKVFDFMRVMCLQYWPLTKfqfreievettevktyshfvirtfklTRTTPESIETRIVKHFHFTEWELDSFPYISAFIELRRRVRQFmekn
        |...  ..   . ....| |                          ..... .  .| . ... . .. .|.| .. | |. . ....    
daAlgKtpllildgngneptaadlellk..........................eelydpelferlgikylripvpDgsaplledfdeflefieea....

PVEAPMVVHCSNGAGRSGAFLALDAnleLMKKTGQlDFFEYAKTLVNSRP-----HLIDSVEQYMFIYEVLSE
. . | .|||. | ||.| |....    |||. |  .. |  . . . ||     ..| . ||| ||.|.| |
dkggpvlvHCkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 231-471 2.4e-14 47.7 In-house 47-283 (303) alignment 
Range on Protein: 231-471
Range on HMM: 47-283/303.0
MMDRNPYPDTLPYDYNRVILpridgdENSHYINASYVNSWLRDKAyVVTQAVRtKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT----KF
 ||.| . | .  |. .| |       .| || |||..   . || ..||        |.||.|. |   .|...|    .. ..     .|      ||
nmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlpl.shtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

QFREIEV-ETTEVKTYSHFVIRTFKLTrttPESIETrIVKHFHFTEWELDSFPYI--SAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLAL-DA
. | | | |  .|.    .|..   ..     .  . ...  |. .|  .| |    . |.    ... .. |     | |     | ||.|.|  .  |
eersirvgefkrvelgdgwvlkvlsvs...ngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

NLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNV
 | | ..   ||.    ... | | | .. . |. ..| .|.| |. | 
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 231-307 2.3e-07 24.6 In-house 34-108 (332) alignment 
Range on Protein: 231-307
Range on HMM: 34-108/332.0
MMDRNPYPDTLPYDYNRVILPRIDGDENshYINASYVNSWLRDKAYVVTQAVRTKPMNAEFWRMVWELGSNCIVMLT
 || |  |    .|..|| |   || ..  . |||.|. . .  ||...||      .  ||||| |   . |... 
nmdmnriphlycfdhsrvelapqdgkdd..fynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfg
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 232-645 3e-58 192.2 In-house 44-447 (515) alignment 
Range on Protein: 232-645
Range on HMM: 44-447/515.0
MDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPL---TKFQF
  .| | . |||| .||.|  |. . .| |.||||..|   ||||. .|.     .. .|||.|..     |.|.||  .  .. | .|||       .|
fkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd.dfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

REIEVETTEVKTYSHFVIRTFKLTRTTpesiETRIVKHFHFTEWELDS-FPYISAFIELRRRVRQfmEKNPVEAPMVVHCSNGAGRSGAFLALDANLELM
 .|.||.  ... .  ..|......      ..| |  ||||||      .  |... | . |.   ... .. |...||| |.|| | ....|  .  .
Gsikvelvsleactggikrkltvlkgd....dsrtvtqfhfteWPdkGvpkhtssllklikevka..dhgqythpliihcsaGvGrtGvvisidsvvaha

KKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVM-CNVQPIEMHLLKERSSMYKAKKNREllETQETHENKLLMHLTPTLRIGDCAGGHRLEN
|.|  .| |.. . . . ||.|.   ||| |||... | ..  |     .|.      .. .   |    .. |.| . |  |.|     ..  |.  .|
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrg..rskmtkefqtlkslcpdppasqtrsgrtrdn

RGKNRDVMVVPPDHARPYLqtlhgESKDYTYINAVEVDGFtrKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQ-RHYPSFIHNKGKANYGPF
. |||    .| .. |  |     .| |. |||| .. |   .. |..|. |  .||  ||... .    |.| |...  . .    .  .    ..| .
hpknrygnnlplqrnrvil.....dspdhdyinasqmkgi..hctfmttqmplpttvsdfwsmvlnnkpstivmlndksqndkscaqywpdansvqfgsy

IVEIMNYHQYPAMTSHMVKV
 |  ..      || . ..|
svstlstssdgdmtirqlqv
0042113 (Phosphotyrosine protein) phosphatases II 232-465 8.8e-58 190.9 In-house 10-241 (245) alignment 
Range on Protein: 232-465
Range on HMM: 10-241/245.0
MDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPL-TKFQFRE
.|.| |.| ||||..||.|. ..||. | |||||||.   . . . .||.  ..   . ||||.||||...|||||. ... || | ||||| ..... .
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygd

IEVETTEVKTYSHFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQFMEKnPVEAPMVVHCSNGAGRSGAFLALDANLELMKK
. |.............||...|..   . |.| | |.|.. |. .. |  .. .... ..||..... . . |..|||| | ||.|.|.|..  ||...|
ftvtllseehlddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmleqlek

TGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
.. ....|  | | . ||. . . .||.|.||.| |
elgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 232-469 3.5e-55 182.6 In-house 62-293 (319) alignment 
Range on Protein: 232-469
Range on HMM: 62-293/319.0
MDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTkvfdfmRVMCLQYWPLTK-FQFRE
 |.| . . |..| |.| | |..| | | |||||.|. . | . |. .|  .   . |.||||.||  .  ||.||      . .| |||||    .  .
kdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntl.adfWrmiweyncstivllt......kdkcsqywplkivikeer

IEVETTEVKTYSHFVIRTFKLTRTTPEsIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKK
 .|. . |.  . .|.| ..|.. . |  . | .. |||  |     | | | .. | ..|| . .|.  .|..||||| |.||.|....||. |. ||.
fkvkvdsveetaeyvvrdielsedgke.kdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke

TGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMC
  |.| ... . | . |..|.... ||.|||  | |  . 
ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
0037934 (Phosphotyrosine protein) phosphatases II 232-465 1.2e-54 180.8 In-house 11-240 (243) alignment 
Range on Protein: 232-465
Range on HMM: 11-240/243.0
MDRNPYPDTLPYDYNRVILpridgdENSHYINASYVNSWlrDKaYVVTQAVRTKP---MNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPlTKFQF
...| |.| ||||..||.|      |.| ||||.... .  .. . .||.  ..    . |.||||.||||...|||||. ..  |. | ||||  ....
lsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gevty

REIEVETTEVKTYSHFVIRTFKLTRtTPESIETRIVKHFHFTEWELDSFPY-ISAFIELRRRVRQFMEK------NPVEAPMVVHCSNGAGRSGAFLALD
 ...|.............||..|.. .... .|| | |.|.. |   . |  .. .... . ||.|.|.      .. . |..|||| | ||.|...|..
gdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

ANLELMkktgQLDFFEYAKTLVNSRPH-LIDSVEQYMFIYEVLSE
  |.|.    ..|..|. |.| . ||.  . . .||.|.||.| |
lmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 232-470 1.5e-54 180.4 In-house 26-258 (284) alignment 
Range on Protein: 232-470
Range on HMM: 26-258/284.0
MDRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTkvfdfmRVMCLQYWPLTK-FQFRE
 |.| . . |..| |.| | |..| | | |||||... . | . |. ||  .   . |.||||.||  .  ||.||      . .| |||||    .  .
kdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntl.adfWrmiweyncstivllt......kdkcsqywplkivikeer

IEVETTEVKTYSHFVIRTFKLTRTTPEsIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKK
 .|. . |.  . .|.| ..|.. . |  . | .. |||  |     | | | .. | ..|| . .|.  .|..||||| |.||.|....||. |. ||.
fkvkvdsveeseeyvvrdielsedgke.kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmke

TGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCN
  |.| ... . | . |..|.... ||.|||  | |  .  
ekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 232-472 1.4e-37 124.0 In-house 39-282 (287) alignment 
Range on Protein: 232-472
Range on HMM: 39-282/287.0
MDRNPYPDTLPYDYNRVILPRiDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFRE-
. .| | | ||.| .||.|   .|.  | |||| || |. .|.|....|.  .  .  .|||.|.|  |  ....|.  .  |  | .|||  .   |  
vkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatv.rdfwravletrsasvitmtreveearlkcykywPerevPmrvG

---IEVETTEVKTYShFVIRTFKLTRTtpESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQFMEKNP--V-EAPMVVHCSNGAGRSGAFLALDAN
   . .   ..|    . .|...|     |. |.|.|| ... .|  .. .    ..| .   |.|..| .       |.|||.. |.|||| .||. . 
GysvvlldydikePe.ygvralrlidl..etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQ
.. ....|..|       | . |  |. .| |. ..|| |      | |
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktnpq
0041856 (Phosphotyrosine protein) phosphatases II 232-472 2.3e-34 114.0 In-house 2-176 (182) alignment 
Range on Protein: 232-472
Range on HMM: 2-176/182.0
MDRNPYPDTLPYDYNRvilpridgdeNSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTkvfdfmrvmCLQYWPltkfqfrei
.|.| |.| ||||..|          ...||||... . |... ...||.   .   |.|.||..||| ..||.||         . .|||         
ldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgplls.tvadflrmlkelgittivnlt.........eelywp.........

evettevktyshfvirtfkltrttpeSIETRIVKHFHFTEWELDSFPYISAFIELRRRVRQfmeknpVEAPMVVHCSNGAGRSGAFLALDanleLMKKTG
                          . ..| . ..... |. .. | .. .... ..|..       . | .|||| | ||.|.. |..    |||| |
..........................ellerlgiqylylpwpDhgvpdldelldfieevle......eggpvlVHCsaGvgRtgtlvaay....lmkklg

qLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQ
 ....|  |.. . ||. . . .|| |.. .| | ......
.vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 232-463 5.2e-20 66.5 In-house 34-291 (297) alignment 
Range on Protein: 232-463
Range on HMM: 34-291/297.0
MDRNPYPDTLPYDYNRVILPRidGDENSHYINASYVNSW--LRDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFR
. .| | | | .| .|| | |  .  .. |||| ||       |  |...|    . .. .||..|.| . . |||..|. .  |  |  ||| .. . .
lrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvd.dfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

E-IEVETTEVKTYSHFvIRTFKLTRTT-PESIETRIVKHFHFTEWE----------LDSF-----------PYISAFIE-----LRRRVRQFMEKNPVEA
.  .|    . ..|     . .||  .     |.| |.|  |  |           |. |           | . | .|     .  ..  .  . | .|
kagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprna

PMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVL
...|||| | ||||  .  |. |. ..|    |     . | . |. |. ..||. ..|.. 
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_eak_pd Subfamily eak 232-389 1.4e-10 35.0 In-house 53-206 (332) alignment 
Range on Protein: 232-389
Range on HMM: 53-206/332.0
MDRNpYPDTLPYDYNRVILPRIDGdENSHYINASYVNSWLRDKAYVVTQAVRTKPMNAeFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK---FQF
..||   . .|||.. | |      ..  ||||| ..     . |..| . . . . | ||.|| |  | .||.| .  .       .|.|      ..|
vnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfa.fwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

REIEVETTEVKTYSHFVIRTFKLTRTTpesiETRIVKHFHFTEWELDSFPYISAFIELRRR
  ..||. |    . .  | ..|..      ||  |.|...  |   . | .  |. ||. 
GildverkefvkrniletrllelskGn....ethrvlhykvfGwtettlpkyedflalrkv
Y_phosphatase Protein-tyrosine phosphatase 233-464 1.6e-58 193.3 Pfam-A 3-234 (235) alignment 
Range on Protein: 233-464
Range on HMM: 3-234/235.0
DRNPYPDTLPYDYNRVILpriDGDEN-SHYINASYVNSWLRDKAYVVTQAVRTkPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWP---LTKFQF
..| |.| |||| .|| |   .|.|. | ||||.||... ..|....||.       ..||||||.  ...|||||.. .  |. | ||||    .. ..
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

REIEVETT-EVK-TYSHFVIRTFKLTRTTPESiETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMekNPVEAPMVVHCSNGAGRSGAFLALDANLE
 .|.||.. ..|   .....|...|. .. || |.|.||..|.|.|.  . |   .....| |.|..    .. ..|.|||||.|.||.| |.|||. ||
gdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

LMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLS
 .......| ... |.| ..||....|.|||.|.|... 
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 233-469 1.6e-58 192.9 In-house 11-244 (250) alignment 
Range on Protein: 233-469
Range on HMM: 11-244/250.0
DRNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVmCLQYWP-LTKFQFREI
..| | | ...|  ||.| . .||..| |||||.....   ||...||.  .. .  .|||||.|  |. |||||.. .  .. . ||||  .  .. ..
eknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqati.edfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdv

EVETTEVKTYSHFVIRTFKLTRTTPEsiETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFmEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKT
 |.  . .... ...|..||.... .  . |||...||. |   . | .  | .||...|..  ...  .||..|.||.| ||||||.|.|| || .|| 
tvsllskeefadytkrklklskakka..derivrqlhfvvWPdkgvPevatavLellkkvqas.qqqagnaPvivqCsaGvgrsGafiaidavlerlkke

GQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMC
 ..| |.. |.| . ||| ..| |||.|.||.. .|. .
kvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
Y_phosphatase Protein-tyrosine phosphatase 233-464 1.6e-58 193.3 In-house 3-234 (235) alignment 
Range on Protein: 233-464
Range on HMM: 3-234/235.0
DRNPYPDTLPYDYNRVILpriDGDEN-SHYINASYVNSWLRDKAYVVTQAVRTkPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWP---LTKFQF
..| |.| |||| .|| |   .|.|. | ||||.||... ..|....||.       ..||||||.  ...|||||.. .  |. | ||||    .. ..
kknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

REIEVETT-EVK-TYSHFVIRTFKLTRTTPESiETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMekNPVEAPMVVHCSNGAGRSGAFLALDANLE
 .|.||.. ..|   .....|...|. .. || |.|.||..|.|.|.  . |   .....| |.|..    .. ..|.|||||.|.||.| |.|||. ||
gdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

LMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLS
 .......| ... |.| ..||....|.|||.|.|... 
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 233-466 1.3e-24 81.3 In-house 39-268 (281) alignment 
Range on Protein: 233-466
Range on HMM: 39-268/281.0
DRNPYPDTLPYDYNRVILPR-IDGDENSHYINASYVNSWLRDKAYVVTQAVRtKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK---FQF
 .| | .    |  || |   .   . . || | |. | .  . |..||  . |   |.||||.|.  . .|||| .. .  |  | .|.|      .||
kknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpk.ketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqf

REIEVETTEVKTYSHFVIRTFKLTRttpeSIETRIVKHFHFTEWELDSFPYISAF-IELRRRVRQfmeKnpvEAPMVVHCSNGAGRSGAFLALDANLELM
 .. |.  .      .|   ..|.       |||.. |. . ||     |  |   ... |..|    .    .| |.||| | ||||...|..  |. .
dklsvsyedstvnkslvttrlnlsy....egetrlithwlwkewpdwqvpessevmlkilrkira...r...stppvihcsagvgrsgtlmaveialqsi

KKTGQLDF-FEY-AKTLVNSRPHLIDSVEQYMFIYEVLSEA
.    |    .  ..  |  |   .....|||.|..|| . 
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 233-465 4.3e-20 66.6 In-house 57-287 (305) alignment 
Range on Protein: 233-465
Range on HMM: 57-287/305.0
DRNPYPDTLPYDYNRVILpriDGDENSHYINASYVNS-WLRDKAYVVTQAVRTKPMNaEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFREI
 .| | |    | . | |   |    |.|| | ||    . .| ....|    . .. ||| || .   . |||| |  .  .. | ||||... . .|.
tknryqdvpcqdqsavkl...dkpspsdyihanyvgcpmipekrficaqgpldqtid.efwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

EVET-TEVKTYSHFVIRTFKLTRTT----PESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQfmeknpVEAPMVVHCSNGAGRSGAFLALDANLE
      |  . |. . |  ..  |.        ..  |.|...|||     |    . .||   .|        . |.||||| | ||.|. .|..  ||
ksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairg......skvpivvhcsagigrtgtivaieyile

LMKKTGQL-DFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
 . .  .   . |  |.| . | . |..  ||.||. |. .
kiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 234-465 1e-47 157.3 In-house 10-238 (239) alignment 
Range on Protein: 234-465
Range on HMM: 10-238/239.0
RNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWL-RDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFREIE
.| | . . ||..||.| ..  |  | ||||||.  .    |||. || .  .. . .||||.|.     ||||| . .  .  | |||| .  .. .. 
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgc.veissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

VETTEVKTYSHFVIRTFKLTRTTpeSIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQfmEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTG
|   . . .. ..|||| ...      | | | ..||| |     | | .| . |||.. .  .  |   | |.||| | ||.|||| .|| |   ||  
vtlrktevfadyiirtfvmsqvg..qteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqakkqk

QLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
 .| |.| |.. . |||.... |||.||.  . |
tvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 234-461 1.7e-47 156.6 In-house 11-235 (239) alignment 
Range on Protein: 234-461
Range on HMM: 11-235/239.0
RNPYPDTLPYDYNRVILPRIDGDENSHYINASYVNSWL-RDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFREIE
.| | . . ||..||.| ..  |  | ||||||.  .    |||. || .  .. . .||||.|.     ||||| . .  .  | |||| .  .. .. 
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgc.veissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

VETTEVKTYSHFVIRTFKLTRTTpeSIETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQfmEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTG
|   . . .. ..|||| ...      | | | ..||| |     | | .| . |||.. .  .  |   | |.||| | ||.|||| .|| |   ||  
vtlrktevfadyiirtfvmsqvg..qteeryvyqyhftvwpdkgvpqyatavlglrrkitk..dslpgarpwvihcsagvgrtgaflvidamlrqakkqk

QLDFFEYAKTLVNSRPHLIDSVEQYMFIYE
 .| |.| |.. . |||.... |||.||. 
tvdifnyvkairedrphmvqtseqyvfihl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 234-465 7.3e-44 144.8 In-house 23-262 (270) alignment 
Range on Protein: 234-465
Range on HMM: 23-262/270.0
RNPYPDTLPYDYNRVILPRIDGDENSHYINASYVN-SWLRDKAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTK-----FQ
 | | | ||    ||.|.... |... |||| ||.    ..|.|. ...     .  .||||.||  ...|||.|.. .  |  | .|||  .     ..
lnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttl.ksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

FREIEVETTEVKTYSHFVIRTFKLTrttPESIETRIVkHFHFTEWELDSFPYIS-------AFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLAL
. .|.| ... .  . ....  .|.    .. | |.| ||....|  .. |  .         ... | ||.. ..   . |..||||.| ||.| ..||
dgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

DANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
|  ..|...|...|  .  . | . |. |.. .||| |.|....|
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 234-463 1.9e-37 123.7 In-house 6-235 (237) alignment 
Range on Protein: 234-463
Range on HMM: 6-235/237.0
RNPYPDTLPYDYNRVILPRIDGDenSHYINASYVNSWL-RDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKF--QFRE
.| | .   ||..||.|    ..  | ||||.|....    | |. .|    ..   .||.|||.     ||||| . .  .. | .||| |.    .  
knrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgp.lesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

IEVETTEVKTYSHFVIRTFKLTRTTPESiETRIVKHFHFTEWELDSFP-YISAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKK
. |  .  . .| . .|.. |.. .    | |... ..|| |     | . .|.. .|... .  .. .  .| ..||| | ||.| || .|| |   |.
ltvslkkkeefsdytvrslllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

TGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVL
   .| ..| ... . ||..|.. .||.||....
kkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 235-467 2.6e-20 67.6 In-house 47-271 (288) alignment 
Range on Protein: 235-467
Range on HMM: 47-271/288.0
NPYPDTLPYDYNRVILPridgDENSHYINASYVNSWLRDKAYVVTQAVRtKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQFREIEVE
. | .    |. || |     |.   ||.|  | |   ..  . .||   .    |.|.|. | . . ||||... .  .    .|.|. . .   |   
dryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPl.ngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl

TTEVKTYSHFVIRTFKLT--RTTPESIETRIVKHFHFTEWELDSFPyiSAFIELRRRVRQFmekNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQ
 | ||     . .. |..  | . |  |. |||. |. ||. |. |    ..   | .  .   . .. |.|||.|.|.||.|..      || .. . .
ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvP..enylsplrllevl...kslqkPivvhssaGvGrtgtlililialeslrlddf

LDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
|   .  . | ..| . | .  ||.... .. | .
lgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 238-310 8.5e-09 29.4 In-house 103-172 (244) alignment 
Range on Protein: 238-310
Range on HMM: 103-172/244.0
PDTLPYDYNRVILPriDGDENSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVF
   ||.|.||| |    |     |||||.|    |   |..||   .     .||.|. |   | .|.|  | 
gaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhplad.tsmdfwkmmlerhvnvlvvlgsve
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 240-324 2.4e-06 21.9 In-house 2-72 (130) alignment 
Range on Protein: 240-324
Range on HMM: 2-72/130.0
TLPYDYNRVIlpridgdeNSHYINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMrvmclQYWPLT
.|.....|.         . .|||||.|    | . |. ||.. ..    .||.|. |   | .|.|  | .       .||| .
alefevsrlq........gntyinasfvGllgrtaeylltqhplad.tsmdfwkmmleryvnvlvvlgsveeed.....eywpds
0044763 (Phosphotyrosine protein) phosphatases II 242-464 8.1e-24 79.6 In-house 1-168 (178) alignment 
Range on Protein: 242-464
Range on HMM: 1-168/178.0
PYDYNRVILPRIDGDENSHYINASYVNswlrDKAYVVTQAVrtkpmnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFqfreievettevkty
|.| .||.|. . | | | |||||..     .  |. ..        |.......||| ..||.||. .  ... |..|||                   
pldrtrvllsnleglersdyinaseil....pglylgslpp......addlellkelgithivnlteelelgflkcdpywpeeag...............

shfvirtfkltrttpesietrivKHFHFTEWE-LDSFPYISAFIELRRRVRQFM-EKNpveAPMVVHCSNGAGRSGAFLALDanleLMKKTgQLDFFEYA
                        ..... ..  . .. .. | |. . ..... ||.    | .|||| | ||||.. |..    ||||  .|...|  
.......................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaay....lmkkl.glsleeai

KTLVNSRPhLIDSVEQYMFIYEVLS
. . . ||  . . .|. ..||. .
elvrerRp.ivpnpgqlrqLyefel
subfamily_egg_pd Subfamily egg 243-464 3.7e-15 50.4 In-house 52-267 (307) alignment 
Range on Protein: 243-464
Range on HMM: 52-267/307.0
YDYNRVILPRIDGDENSHYINASYVNSWLRDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKVFDFmrVMCLQYWPLTKFQF-----REIEVETTE
 |. || |    |     .| | .|.       ....||   |    .|||||..   . |||||   .     |  ||| .. .        ...|. .
kdssrvklelrrGqylddfihanrvkGkpllnefilaqap.lkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlk

VKTYSHFVIRTFKLTRTTPEsIETRIVKHFHfteWELDSFPYISAFIELRRRVRQfmeknpVEAPMVVHCSNGAGRSGAFLALDANL-ELMKKT-GQLDF
|.  .  . |  ||    ..  | | ..|.    ....    .   ... |..|.      .  |.||.. .|  ......|..  | .|..    .   
vdskadplfrvtklklvGgd.deerflehwq...gdvnnssdvysplrvlrklrn......lskpvvvqdilGvskaatlvaieiallsllrGpitkslv

FEYAKTLVNSRPHLIDSVEQYMFIYEVLS
 .  . |   |.  ..|| .|.|.| .. 
lravvflrlrrrlsvesvllylfvyrlvl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 246-491 4.4e-11 37.4 In-house 33-272 (290) alignment 
Range on Protein: 246-491
Range on HMM: 33-272/290.0
NRVILPRIDGDENSHYINASYVNsWLRDKAYVVTQAVRTKP------MNAEFWRMVWELGSNCIVMLTKVFDFMRV----MCLQYWPLT---KFQFREIE
.||.|       |. || |..|  .  . . ..||. ..|          .|| |. .  .. .||| .. .  .      | .| | .   . .|  ..
trvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VETTEVKTYSHFVIRTFKLTRttpESIETRIVKHFHFTEWELDSFPYISA-FIELRRRVRqfmeknPVEAPMVVHCSNGAGRSGAFLALDANLELMK-KT
|. ..  .   . .|.  ..    .  |   |.|  . .|.  . .  .  ...| . |.        ..|..||| .|  || |. |..    ..  ..
vkCkskekeddvetRelvvkf...ddeeeftvtHsllkgWnklnvqedtktllsliqkvk......asktpvivHcvdGiSrsAalaaiilgyQkiaets

GQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSeavmcnvqpieMHLLKERSSMYKAKKN
|.. . .  |.| . | ..| | ... |.  ..            . . .. ..... ...
gsvkledvlkalrkqralaitsalelafvdagiv...........llaievldqfaeeete
0046846 (Phosphotyrosine protein) phosphatases II 252-463 1.2e-27 92.2 In-house 5-169 (176) alignment 
Range on Protein: 252-463
Range on HMM: 5-169/176.0
RIDGDENSHYINASYVNSWlrdkAYVVTQaVRTKPMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLtkFQ---Freievettevktyshfvirt
..  |....||||... .     ....||   .    |.|..|..||| ...|.||. ... |. | .|||.  ..   .                    
llgldldldyinanlilgs....rpiatq.gplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi....................

fkltrttpesietrivkHFHFTEWELDSFPYISAFIELRRRVRQFMEKNpveAPMVVHCSNGAGRSGAFLALDanleLMKKTGQLDFFEYAKTLVNSRP-
                 ..... |.  . | .....|| . .|.. ...    | .|||| | ||.|...|..    |...  .|. .|  ... . || 
.................qylhlpwpDhgvpdlelllellefirealkeg...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRpl

HLIDSVEQYMFIYEVL
. . . ||| |.||..
gavqtpeQyrflyefe
0043147 (Phosphotyrosine protein) phosphatases II 255-461 7.4e-28 92.8 In-house 1-155 (172) alignment 
Range on Protein: 255-461
Range on HMM: 1-155/172.0
GDENSHYINASYVNSWLRDKAYVVTQAVrTKPMNAEFWRMVWELGSNCIVMLTKVfdfmrvmclqywpltkfqfreievettevktyshfvirtfkltrT
|||.|.||||||.. .   . ...||.. .    |.||||..||| ..||.||.                                             .
gdegsdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltel............................................l

TPESIETRIVKHFHFTEWELDSFPYISAFIELRRRVRQFMeKNPVEAPMVVHCSNGAGRSGAFLALDANLelmkktGQLDFFEYAKTLVNSRPHLIDSVE
.. . ..| . ..... |.  . | .. ..|. . .....  .  . |..|||| | ||.|.. |..  |       .|...|  ... . ||. . . .
ydpellerlgiqylylpwpDhgvpllellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYMFIYE
||.|.|.
qyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 258-466 1.3e-32 109.0 In-house 3-224 (272) alignment 
Range on Protein: 258-466
Range on HMM: 3-224/272.0
NSHYINASYVNSW---LRDKAYVVTQAVRTKPmNAEFWRMvWELGSNCIVMLTKVFDFMRVMCLQYWP-------------LTKFQFREIEVETTEVKTY
 |.||||..|. .   ......  ...  .    |.|||. .||| ..||.|....   |. | .|||              .   .  . | .......
lsgyiNardvggygrvvkpgrlyrsggplplt.aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

SHFVIRTFKLTRTTPESIEtRIVKHFHFTEWELDSFPYiSAFIELRRRVRQfmeknpvEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLD-------
.....|.. ||.. . .   | | |.|.| |  .. |. .|..|| . ...       . |..|||| | .|.| . ||.  |. . ..  .|       
ldyilrellltlllsagea.revmhlhytdwpdhgvpq.eallellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-FFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEA
  .|. . |   ||. . . |||.|.||.| |.
yleeaveelraqrpgavqteeqylflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 259-461 5.9e-34 112.6 In-house 2-164 (174) alignment 
Range on Protein: 259-461
Range on HMM: 2-164/174.0
SHYINASYVNSWLRDKAYVVTQAVRTkpmnaeFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLtkfqfreievettevktyshfvirtfkltrttPES
|.|||||... . . . ....|.  .      ||.|..|||....|||.. .   ...| .|||                                   .
sdyinaspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe................................lre

IETRIVKHFHFTEWELDSFPYISAFIELRRRVRQFMEKnPVEAPMVVHCSNGAGRSGAFLALDANLELMKkTGQLDFFEYAKTLVNSRPHLIDSVEQYMF
 ..| . ..... |. .. | .| ..|. ..|...... . . |..|||| | ||.|.. |..  | ... ..  | ... ..| . ||. . . .||.|
dlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

IYE
.|.
lyy
0051082 (Phosphotyrosine protein) phosphatases II 259-463 4e-23 77.1 In-house 3-149 (151) alignment 
Range on Protein: 259-463
Range on HMM: 3-149/151.0
SHYINASYVNSWlrdkaYVVTQAVrtkpmNAEFWRMVWELGSNCIVMLTKVFDFMrvMCLQYWPLTKfqfreievettevktyshfvirtfkltrttpes
|.|||.||| .      . ....       |.|.....||| ..||.|.. .     .| .|.| .                                  
sdyinfsyvtgg.....lyrsggp.....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

ietRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQfmeknpV-EAPMVVHCSNGAGRSGAFLALDANLeLMkktgqLDFFEYAKTLVNSRPHLIDSVEQY
   . |.|.... |   ..| .  |..|. . ...        . |..|||| | ||.|.. ||.  | |.     ....|  . .  .||... . .|.
...ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqf

MFIYEVL
.|.. .|
lfqlfal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 261-458 5.3e-17 56.5 In-house 77-272 (301) alignment 
Range on Protein: 261-458
Range on HMM: 77-272/301.0
YINASYVNSWLRDKAYVVTQAVRTKpMNAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKFQ---FR--EIEVETTEVKTYSHFVIRTFKLTRTT
 | | ....  . . ...||.  ..    .|| |.     . ||||..  . .  .| .| |..  .       .|.....|.    . . ||.... .|
PihanwiptsGhphrfiatqgPlkn.tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedst

pESIETRIVKHFHFTEWELDSFPYISAfiELRRRVrQFMEKnpVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQ
 . ..|| | |. ..||     |   |  ||   . ... |   | |.|||||.| ||| ||.. .     ..   .... |  | | . | . .  ..|
.gkfatrtvthyqysewtdrgvPksha..elfdlm.elvkk..sekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsq

YMF
  .
lyw
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 274-462 4.4e-29 96.1 In-house 5-199 (199) alignment 
Range on Protein: 274-462
Range on HMM: 5-199/199.0
KAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKF---QFREIEVETTEVKTYSHFVIRTFKLTRTTPESIETRIVKHFHFT
. |..||    . | |.||.|||| ||  |||.        .    ||| |.    ..  . | |  . | . ..| .. ||  |     || . |. ||
rryiatqhplretm.adfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWELDSFPYISAFIELRRRVRQFMEKNP--VEAPMVVHCSNGAGRSGAFLALDANLEL--MKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEV
 |   . | .. |. .    |.   |     .||..||||.| | .| |.|||  .      ||  .|.|| || | ..|  .| |...| |||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 274-462 5.2e-29 95.8 In-house 4-198 (198) alignment 
Range on Protein: 274-462
Range on HMM: 4-198/198.0
KAYVVTQAVRTKPMnAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLTKF---QFREIEVETTEVKTYSHFVIRTFKLTRTTPESIETRIVKHFHFT
. |..||    . . |.||.|||| ||  |||.        .    ||| |.    ..  . | |  . | . ..| .. ||  |     || . |. ||
rryiatqhplretl.adfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

EWELDSFPYISAFIELRRRVRQFMEKNP--VEAPMVVHCSNGAGRSGAFLALDANLEL--MKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEV
 |   . | .. |. .    |.   |     .||..||||.| | .| |.|||  .      ||  .|.|| || | ..|  .| |...| |||.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
0049260 (Phosphotyrosine protein) phosphatases II 288-461 1.5e-22 75.3 In-house 22-144 (152) alignment 
Range on Protein: 288-461
Range on HMM: 22-144/152.0
NAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWpltkfqfreievettevktyshfvirtfkltrttpesietrivkHFHFTEWELDSFPYISAFIELR
 |.||||..||| ..|||||. ... .. | ||.                                            ..... |. .. | .| ...  
ladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllfl

RRVRQFMeKNPVEAPMVVHCSNGAGRSGAFLALDANLelmkktGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYE
 .. ... .   . | .|||| | ||.|.. |..  |       .....|. . . . ||. . . .|..|.||
llfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 288-467 3e-19 64.1 In-house 41-221 (255) alignment 
Range on Protein: 288-467
Range on HMM: 41-221/255.0
NAEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT---KFQFREIEVETTEvkTYSHFVIRTFKLTRTTPESIETRIVKHFHFTEWELDSFPyisafi
 ..|....   ... .|||.   .  .. | .|.||    | .. ...| ||.  . .. |.|| ..| |  |  .|. |||.... |     |      
vdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaP......

ELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLEL-M-----KKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
|| | ... .       ..|||||.| ||| ||   .      .      .|..||. .  . | ..|.  |    |  |   .. . |
elareilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 289-477 1.2e-17 58.7 In-house 48-237 (263) alignment 
Range on Protein: 289-477
Range on HMM: 48-237/263.0
AEFWRMVWELGSNCIVMLTKVFDFMRVMCLQYWPLT---KFQFREIEVETTEVKTysHFVIRTFKLTRTTPESIETRIVKHFHFTEWELDSFPyisafiE
..|....   ... .|||.   .  .. | .|.||    | .. ...| ||.|.     ...| .|. |  | ..|. |||. .. |     |      |
dkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndp......e

LRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELM------KKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAVMCNVQPIEMH
| | ... .. .    ..|||||.| ||| ||   .     |       .|..||. .  . | .||.  |    |  |   .. . |. |    |..
lareilnilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgele
0048076 (Phosphotyrosine protein) phosphatases II 348-463 7.7e-17 56.8 In-house 35-139 (145) alignment 
Range on Protein: 348-463
Range on HMM: 35-139/145.0
TFkltrTTPESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQFMEKNpveAPMVVHCSNGAGRSGAFLALDanleLMKKTGqLDFFEYAKTLVNSR
..    |. .. ..| . ..... |.  . | . . ..|. . ........    |..|||| | ||.|.. |..    ||.. | ....|  . . . |
nl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqr

PHLIDSVEQYMFIYEVL
|. . ...|. |.||..
pgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 351-461 9.9e-16 53.2 In-house 36-139 (144) alignment 
Range on Protein: 351-461
Range on HMM: 36-139/144.0
LTRTTPESIETRIVKHFHFTEWELDSFPYI-SAFIELRRRVRQFMEKNpveAPMVVHCSNGAGRSGAFLALDanleLMKKTGqLDFFEYAKTLVNSRPHL
|| . .   ..| . ..... |.  . | . . ..|. . .....|..    |..|||| | ||.|.. |..    |||| | |...|  . . . ||. 
lteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg...gpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpga

IDSVEQYMFIYE
. . .|..|..|
vpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 358-478 2.8e-18 60.5 In-house 85-205 (440) alignment 
Range on Protein: 358-478
Range on HMM: 85-205/440.0
SIETRIVKHFHFTEWELDSFPYIS-AFIELRRRVRQFMEKNpVEAPMVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQY
.||.| .|..|.  |   . | ..   ... . | .  ||   ..|..|||| ||||.|  .|.|. |   |.. |.| | . ... |.||..... |||
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy

MFIYEVLSEAVMCNVQPIEMHL
 |..|.. |...|    |    
afvheavlegllcgdtliledd
PTPc_DSPc_SM00012 364-464 7.5e-26 85.7 In-house 2-104 (105) alignment 
Range on Protein: 364-464
Range on HMM: 2-104/105.0
VKHFHFTEWELDSFPY-ISAFIELRRRVRQFMEKNPVEAPMVVHCSNGAGRSGAFLALDANLELMKKT-GQLDFFEYAKTLVNSRPHLIDSVEQYMFIYE
|||.|.|.|   . |   ....|| | |.....|.  ..|.|||||.|.||.| | |||  |. ..|. ...|.|.. | | ..||..... |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VLS
.| 
all
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 397-462 2.1e-06 21.7 In-house 259-339 (350) alignment 
Range on Protein: 397-462
Range on HMM: 259-339/350.0
NPVEAPMVVHCSNGAGRSGAFLALDANLE-------LMKKTGQLDFFEYAKT--------LVNSRPHLIDSVEQYMFIYEV
|   .|..|||| | || | ...||  |.       | |.  .||     .         | . |  .. ...|..|||| 
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea
subfamily_CG42327_pd Subfamily CG42327 400-465 1.3e-10 35.5 In-house 247-313 (319) alignment 
Range on Protein: 400-465
Range on HMM: 247-313/319.0
EAPMVVHCSNGAGRSGAFLALDANLELMKKT-GQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSE
  |.|||||.|.||.|  .| | ... ....   .|  .    . . | . . ..||| ||| ||||
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 403-467 8.9e-11 36.0 In-house 1-65 (69) alignment 
Range on Protein: 403-467
Range on HMM: 1-65/69.0
MVVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
|||||| |.||.|.|.|.  ..  .|    .| |.  . .   || ..    .|.||.. | ||.
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 404-467 2.2e-10 34.8 In-house 1-64 (69) alignment 
Range on Protein: 404-467
Range on HMM: 1-64/69.0
VVHCSNGAGRSGAFLALDANLELMKKTGQLDFFEYAKTLVNSRPHLIDSVEQYMFIYEVLSEAV
||||| |.||.|.|.|.  ..  .|    .| |.  . .   || ..   ..||||.. | ||.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Ptp69D_pd Subfamily Ptp69D 480-813 1.3e-35 118.0 In-house 8-301 (307) alignment 
Range on Protein: 480-813
Range on HMM: 8-301/307.0
KERSSMYKAKKNRELLETQethENKLLMHLtptLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPK
. .... . |.. . . ..   | . | .        ..  ... ||  |||   ... |. |  |... |.  | .||||  . |.  | .||.   | 
dleealksrkrdtdfglak...eyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingke.dsdYinasfikgykekkkfiaaqdPv

QSTVDSFWTLIYDHACHTVVNLSNQGSQRH--YPSFIHNKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPHQVPPMkvdpegkgvskltfmisdimat
..|.. || .| .   ...| ||| . . .   . .  .  . .||  .|.... .. .  .   ..| |  .... .                      
eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev......................

gaqnqqiDAEVRICcVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRIN
       ... ..    .   |. . ||| ...||...|...|.  |         | .|   .||.| |...  .. ..|.  ...||.|. || .| .
.......edsrkvv.qyhytgWk.DskvPevargllklieqvrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsq

RPQLIDMKDEYKYLYDVMLHWYM-TNPDYRIYDKEDS
|. |..  . |..||  .| . . .. |  . | ||.
RnllvqsleqYvflyralldyssygdtdedvddleda
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 483-606 9.7e-07 22.8 In-house 4-140 (350) alignment 
Range on Protein: 483-606
Range on HMM: 4-140/350.0
SSMYKAKKNRELLETQETHENKLLMHLTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQ--------TLHGES-KDytYINA--VEVD--GFTRK
| . | .| . ..  ..| . .| ..   .  . |    . .|   ||| . ..| .|.|  |.          |  | .|  ||||  ...   .   .
skvqkrsklkliitknstvksrlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnD..YinanYlkltrfsvein

AEF--IVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS
..|  | |  | .|||| |...|.    . .. |...  
pdfkYiatqaPlpstvddfykvillnkvkvilsltsdve
RNA_lig_T4_1 RNA ligase 487-591 8.1e-06 11.8 Pfam-A 80-184 (221) alignment 
Range on Protein: 487-591
Range on HMM: 80-184/221.0
KAKKNRELLETQETHENKLLMHLTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSF
.|.. ..||. .  ...| |  |  .|.  ..     | .. ... |.  . .... ||. |. .. ..  ..  ||. |... .|..... . ......
haevgekllkrtlessgktleelaeelleknlTavfElcddsfeehvlayeeeklglylhglnnntgefstlsssevakfakefgfkqvkylqlesleev

WTLIY
 ... 
kkfla
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 490-649 1.2e-22 75.5 In-house 20-180 (298) alignment 
Range on Protein: 490-649
Range on HMM: 20-180/298.0
KNRELLETQETHENKLLMHLTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTL
....   |. ..| . | . . ...      ... ||. |||   ... |..|  |.. . . .. .||||. .......  ||.|. | ..||  || .
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrnafiatqaPltetvedFWrm

IYDHACHTVVNLSNQGS--QRHYPSFIHNKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRP
. ..   |.| | |     . .|. .  ..||..|| . |.... ...  ...  .|| |. 
vteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkk
subfamily_CG7180_pd Subfamily CG7180 498-805 1.5e-140 462.0 In-house 14-296 (296) alignment 
Range on Protein: 498-805
Range on HMM: 14-296/296.0
QETHENKLLMHLTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYtYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHT
.   |.||...|||.|.|||||||.|.|||.|||||.|||.|..|..|..|.||.|.. |||||.||.|..|.|.||||.||..|||.||.|.||.....
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd.YinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

VVNLSNQGSQRH-YPSFIHNKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRphqvppmkvdpegkgvskltfmisdIMATGAQNQQIDAEVRICCVIQV
||.|........ |||...||.|..||...|||....||........|..|.                         |.|...|..|..||.||....|.
vvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkk.........................ivalteqekqvkaetRivklfql

RMWPIENKVPLSTTGLIDVIKMARSWRKRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVML
..|..|.||||||..||......|.||......||..|..|.|..|.||.|||..............|||||.|||..|..||||.....||||.|||.|
teWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

HWYMTNPDY
.....|.|.
eavlcnkdk
subfamily_PTPN13_pd Subfamily PTPN13 500-797 1.1e-15 52.6 In-house 14-267 (273) alignment 
Range on Protein: 500-797
Range on HMM: 14-267/273.0
THENKLLMHLTPTLrigDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGeskdytYINA--VEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHT
..| | | .| |..   .|  |.. ||. |||   |.| |..|  |.   |      ||||  ..|     . |.|..  |   ||. || ....  .. 
aeefkelrelkpld...tcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

VVNLSNQgsqrhypsfiHNKGKanygpfiVEIMNYhqYPAMTSHMVKVMKRphqvppMKVDPEgKGVSKLTFMISDIMATGAQNQqidaEVRICCVIQVR
.. ....           .|||       |    |  .|  ... .||  |      ..|. . | . . .| ..... .  . .    |.|    ..  
iamvtle..........kekgk.......vkchry..wPesknkklkvsnr......levell.kvqkldgfvvralavkdsesg....esrevahlnfv

MWPiENKVPLSTTGLIDVIKMARSWRKrapdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLH
 || . .|| |.. |. ...  |. ..      .. | .|    |. | |..|  .. .. .. |.|.|| . |. .|  |  ..  || | . | ..|.
kwP.dhgvPssaaellqfvaevrrlqt......dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
0039614 (Phosphotyrosine protein) phosphatases II 502-802 4.1e-50 166.3 In-house 37-292 (297) alignment 
Range on Protein: 502-802
Range on HMM: 37-292/297.0
ENKLLMHLTPtlrigDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGFTR-KAEFIVTEWPKQSTVDSFWTLIYDHACHTVVN
| . |. |.|     |.  ... ||. ||| . ..| || | .|... |   | .||||  |||. . . .||.| .| ..||..|| ..... ....|.
efeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivm

LSNQGSQRH-YPSFIHNKGKaNYGPFIVEIMNYHQYPAMTSHMVKVmkrphqvppmkvdpegkgvskltfmisdimatgaqnQQiDAEVRICCVIQVRMW
| .     . ....  ..|  .||.| |. ....... .|    .|                                    .  . |.|.. ..|.  |
Ltklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlev....................................tn.ngesrtvthfqytgw

PiENKVPLSTTGLIDVIKMARSWRKRApdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWY
| ...|| |.. |.......|......   |. .|..|....||.| |..|.| ....|..  ..|||..|||..|  ||. . . . |..|||..|...
p.dhgvppslellleflelvrealael...pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

MTN
...
krk
0045450 (Phosphotyrosine protein) phosphatases II 502-800 4.4e-49 163.2 In-house 32-305 (307) alignment 
Range on Protein: 502-800
Range on HMM: 32-305/307.0
ENKLLMHLTPTLrIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEV--------DGFTRKAEFIVTEWPKQSTVDSFWTLIYDH
| . |...|..| .|..  ....||. ||| . ..| || | .|..|.|...|  ||||  |        ||. .| .||.| .|...||..|| .....
efekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq

ACHTVVNLSNQ---GSQRHYPSFIHNKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKR-PHQvppmkvdpegkgvskltfmisdimatgaqnqqidaEVR
 ....|.|..    |..  .. . ..... .||.| |. ....... .| . ..|    . .                                   |.|
gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg...................................esr

ICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRApdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHE---VDVFHAVKMMRINRPQLIDMKD
......   || . .|| |.  |.| |...|.....    |. .|..|... ||.| |..|.| ....|.. ...   ||...|||..|  ||. .   .
tvthfhytgwp.dhgvppsfeelldfieevrkaleel...pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe

EYKYLYDVMLHWYM
 |..||...|....
qyrflyeallelll
0036941 (Phosphotyrosine protein) phosphatases II 503-805 6.5e-53 175.3 In-house 16-283 (297) alignment 
Range on Protein: 503-805
Range on HMM: 16-283/297.0
NKLLMHLTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLqtlhgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS
 |  ..|.| | .|..  ....||. |||   ..| || | .|     .. .  ||||  |||. .| .||.|..|...||..|| ..... ....|.|.
lkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NQG---SQRHYPSFIHN-KGKANYGPFIVEIMNYHQ--YPAMTSHMVKVMKRPHqvppmkvdpegkgvskltfmisdimatgaqnqqidAEVRICCVIQV
.      .  .. . ..  .  .||.|.|. .....  .. .| . ..| .                                       |.|.. ....
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn...................................gesrtvthfhy

RMWPiENKVPLSTTGLIDVIKMARSWRKRApdrPETKPTIVMSHNGVSRVGVYIGANICIDQMD---IDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYD
  || ...|| |.. |.| |...|...| .   |. .|..|....||.| |..|.| ....|..   . ..||.. |||..|  ||. . . . |..||.
tgwp.dhgvpespaslldfielvrkvlkll...psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye

VMLHWYMTNPDY
..|......  .
allellkkkltk
0050432 (Phosphotyrosine protein) phosphatases II 503-801 2.7e-52 173.4 In-house 48-301 (308) alignment 
Range on Protein: 503-801
Range on HMM: 48-301/308.0
NKLLMHLTPtlrIGDCAGGHRLENRGKNRDVMVVPPDHARPYLqtlhgeSKDYTYINAVEVDGF--TRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVN
 . |....|   ....  . . ||. ||| . ..| || | .|      ... .||||  |||.   .. .||.| .|...||..|| ..... ....| 
feellsvkp...lleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvm

LSNQGSQ--RHYPSFIHN---KGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPhqvppmkvdpegkgvskltfmisdimatgaqnqqiDAEVRICCVIQ
| .        .. .  .   .|  .||.| |......... .|   .....                                     | |.|.. ...
LtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg...................................dgesrtvthfh

VRMWPiENKVPLSTTGLIDVIKMARSWRkrapdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVM
   || . .|| |.. |.| ....|...       . .|..|....||.| |..| . ....|.. ...||||.|||..|  ||. .  .. |..||...
ytnWp.dhgvPpspeilldflelvrksl.......pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

LHWYMT
|.....
leylkl
0046845 (Phosphotyrosine protein) phosphatases II 506-801 1.7e-51 170.7 In-house 9-276 (284) alignment 
Range on Protein: 506-801
Range on HMM: 9-276/284.0
LMHLTPTlRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGF-----TRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVN
|..||.. .. ..  ....||. ||| . ..| || | .|..|.|...| .||||  |||.      .| .||.| .|...||..|| ..... ....| 
llsltvk.lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVm

LSNQGSQR---HYPSFIHNKGKANYGPFIVEIMNYHQYPAMTSHMVKVmkrphqvppmkvdpegkgvskltfmisdimatgaQNQQIDAEVRICCVIQVR
| .  .     ... . ..... .||.|.|......... .| .....                                  .| ... |.|.. .... 
ltelvengrekcaqYwplegevltygdftvtllseevkddytvrtlel..................................tnlgytgesrtvthfhyt

MWPiENKVPLSTTGLIDVIKMARSWRKRapdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDH---EVDVFHAVKMMRINRPQLIDMKDEYKYLYDV
 || ...|| |.. |.. ....|.....   .|  .|..|....||.| |..| . ....|.. ..   .|||..|||..|  ||. . . . |...|..
swp.dhgvppspedlleflrlvrellen...lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea

MLHWYMT
.|.....
lleylkl
0051299 (Phosphotyrosine protein) phosphatases II 509-799 8.2e-51 168.5 In-house 32-286 (288) alignment 
Range on Protein: 509-799
Range on HMM: 32-286/288.0
LTPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGeSKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG---
|.. |  ...  ... ||. ||| . ..| || | .|..|.| . . .||||  .||. .| .||.|..|...||..|| ..... ....| | .     
llsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelg

---SQRHYPSfihnKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKR--PHqvppmkvdpegkgvskltfmisdimatgaqnqqIDAEVRICCVIQVRMWP
   . . .|.    .|. .||.. |......... .| . ..| .   ..                                  | |.|.. ....  ||
rekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlld.................................gdgesrtvthfhytnwp

iENKVPLSTTGLIDVIKMARSWRKrapdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWY
 .. || |.. |.| ....|....     .  .|..|....||.| |..| . ....|..  ..|||..|||..|  ||... . . |...|...|...
.dhgvpdspellldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 510-799 3.7e-48 159.7 In-house 22-272 (273) alignment 
Range on Protein: 510-799
Range on HMM: 22-272/273.0
TPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLqtlhgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQ--
...  ....  . . ||. |||   ..| || | .|     ....  ||||  |||. .| .||.|..|...||..|| ..... ....| | .  .   
lslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

-RHYPSFIHNKG--KANYGPFIVEIMNYHQYPAMTSHMVKVMKRPhqvppmkvdpegkgvskltfmisdimatgaqnqqiDAEVRICCVIQVRMWPiENK
  ... . .. |  . .||.|.|......... .| . ... .                                     . |.|.......  || ...
ekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...................................tgesrtvthfhytgwp.dhg

VPLSTTGLIDVIKMARSWRKRAPDRpetKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWY
|| |.. |.. |...|.... .|.    .|..|....||.| |..| . ...||.   ..|||. |||..|  ||  .   . |..||...|...
vppslesllefielvrkalealpsn...gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045098 (Phosphotyrosine protein) phosphatases II 510-803 6.1e-41 136.0 In-house 17-276 (278) alignment 
Range on Protein: 510-803
Range on HMM: 17-276/278.0
TPTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYlqtlhgeskDytYINAVEVDGFtrKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ-----
 ..  ....  . .|.|. ||| . ..| || | .         |  ||||  .||.  . .||.| .|..|||..|| ..... ....|.| .      
lllgipseitpalylgnldknRykdilpydhsrVk.........d..YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-GSQRHYPSfihnKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRP----HqvppmkvdpegkgvskltfmisdimatgaqnqqidAEVRICCVIQVRMW
    . .|.    .|  .||.| |......... .| .. .|        .                                    | |  ....   |
ekcaqywpe....ggsltygdftvtllseevlddytlrtllvtnltvered...................................lesrgvthlhylpw

PiENKVPLST--TGLIDVIKMARSWRKRAPDRP--------ETKPTIVMSHNGVSRVGVYIGANICIDQMdiDHEVDVFHAVKMMRINRPQ-LIDMKDEY
| .. || ..  . ....... |...|.. ..         . .|..|  . ||.| |....| ......  .. ||...|||..|  ||.  . ... |
p.dhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqy

KYLYDVMLHWYMTNP
..||...|.... ..
rflyefllelllrgk
0043336 (Phosphotyrosine protein) phosphatases II 511-799 4.5e-48 159.5 In-house 30-277 (278) alignment 
Range on Protein: 511-799
Range on HMM: 30-277/278.0
PTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLhGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG-----
..  ....  ....||. ||| . ..| || | .|. | |.  | .||||  |||. .. .||.| .| ..||. || ..... ..|.|.| .       
lsfkldtysiallpenkdknrykdilpydhsrvklsll.ggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrv

-SQRHYPsfihnKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPHQvppmkvdpegkgvskltfmisdimatgaqnqqidaEVRICCVIQVRMWPiENK
 ... .|     .|  .||.| |. ....... .| .  .| .. .                                    |.|......   || ...
kcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdg...................................esrtvthyhylgwp.dhg

VPLSTTGLIDVIKMARSWRKrapdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWY
|| |.. |.| .|..|....     .. .|..|....||.| |..|.. ....|..  ..||...|||..|  ||. . . . |..||...|...
vpeslsllldflkavreale.....dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 511-717 1e-10 35.6 In-house 30-159 (392) alignment 
Range on Protein: 511-717
Range on HMM: 30-159/392.0
PTLRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN--QGSqr
|   | . . ...  |  |||   ..| | ||  |. .  .. |  |.||  ...|  .  .| .. |. ...| || .....   |.. ...  .|   
pgpdiypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..

hypsfihnkgkanygpfiveimnyhqypamtshmvkvmkrphqvppmkvdpegkgvskltfmisdimatgaqnqqIDAEVRICCVIQVRMWPiENKVPLS
                                                                              ..| ..  ..  || .. ||  
...........................................................................kgddartvaqfhftewP.dkdvpkh

TTGLIDVIK
|. |. .||
tssllkfik
DSPc_SM00195 512-799 1.8e-55 183.5 In-house 16-262 (263) alignment 
Range on Protein: 512-799
Range on HMM: 16-262/263.0
TlrigDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGEsKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS--QRH
.    ..  ... .|. |||  ...| || |  |.. ... .. .||||  ..| ..| ..|.| .|..|||..||...... ....| |...    ...
k....etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkek

YPSFIHNK--GKANYGPFIVEIMNYHQYPamtshmvkvmkrphqvppmkvdpegkgvskL-------------TfmisdimatgaqnqqidAEVRICCVI
  .. ...  || ..| . |.........                                            .                  | | . ..
cdrywpeesggketfgkisvklvevekkk..............................deiilrtleltkegk.................eetrkvtqy

QVRMWPIEnKVPLSTTGLIDVIKMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDV
|.. || . .|| ||. ..............      ..|..|....||.| |... ..|...... ...||.|. ||..| .||........|...|..
qyknWpdh.gvpdstksvlellravkksksts.....sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea

MLHWY
.|...
ileyi
PTPc_SM00194 512-799 1.8e-55 183.5 In-house 16-262 (263) alignment 
Range on Protein: 512-799
Range on HMM: 16-262/263.0
TlrigDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGEsKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS--QRH
.    ..  ... .|. |||  ...| || |  |.. ... .. .||||  ..| ..| ..|.| .|..|||..||...... ....| |...    ...
k....etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkek

YPSFIHNK--GKANYGPFIVEIMNYHQYPamtshmvkvmkrphqvppmkvdpegkgvskL-------------TfmisdimatgaqnqqidAEVRICCVI
  .. ...  || ..| . |.........                                            .                  | | . ..
cdrywpeesggketfgkisvklvevekkk..............................deiilrtleltkegk.................eetrkvtqy

QVRMWPIEnKVPLSTTGLIDVIKMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDV
|.. || . .|| ||. ..............      ..|..|....||.| |... ..|...... ...||.|. ||..| .||........|...|..
qyknWpdh.gvpdstksvlellravkksksts.....sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyea

MLHWY
.|...
ileyi
subfamily_ptpA1_pd Subfamily ptpA1 513-605 6.3e-10 33.3 In-house 34-124 (418) alignment 
Range on Protein: 513-605
Range on HMM: 34-124/418.0
LRIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGeSKDYTYINAVEVDGFTRKaEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG
.   . . | .  |  |||   ..| .|.|  |. ..   .   ||||  .||   | .||.|. |   |.  || ....  |. .| || . 
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd.kegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsres
0040438 (Phosphotyrosine protein) phosphatases II 514-802 8.7e-50 165.1 In-house 31-279 (317) alignment 
Range on Protein: 514-802
Range on HMM: 31-279/317.0
RIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGeSKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG------SQ
 . ..  ....||..||| . ..| || | .|. | |   | .||||  |||. .| .||.|  |...||..|| ..... ....|.| .        ..
kldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekca

RHYPSfihnKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPHqvppmkvdpegkgvskltfmisdimatgaqnqqidAEVRICCVIQVRMWPiENKVPL
. .|.    ... .||.|.|......... .| . ..| .  .                                    |.|.. ...   || . .|| 
qYwpl....getltygdftvtllseeelagitlrtlevedlgd...................................sesrtvthfhytgWp.dhgvpp

STTGLIDVIKMARSWRKrapdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMTN
|.. |.| ....|....     .. .|..|....||.| |..|.| ....|..  ..|||..|||..|  ||. . . . |..|||..|......
spdllldfleavreale.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 514-648 8.8e-16 52.8 In-house 35-171 (288) alignment 
Range on Protein: 514-648
Range on HMM: 35-171/288.0
RIGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ--GSQRHYP
.  .   |.. .|  |||   ..| |. |  |. |. | ..  ||||  .||  .| ..| |  | ..||. || |.|..  .|.| |..   | ...  
ktksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

SFIHNKGK-ANYGPFIVEIMNYHQYPAMTSHMVKVMKR
 .  ...|  ||| . |.... ..   .. . . . |.
eYWPdadkpknyGsvtvtlveskeledfvlrklllekk
subfamily_PTPN14_pd Subfamily PTPN14 515-645 2.1e-12 41.7 In-house 38-174 (300) alignment 
Range on Protein: 515-645
Range on HMM: 38-174/300.0
IGDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ------GSQR
 ...  ..  ||  |||.  |.| ...|  |.. . .|..|     ..|   ... ..||.  | . ||  || .....  . .| | ..       | .
dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

HYPSFIHNKGKANYGPFIVEIMNYHQYPAMTSHMVKV
..|.  ..| ....| | |     .. .... . .|.
yfPkleskkktvefgkfkvttkfsedsdsvittglkl
subfamily_PTPRA_pd Subfamily PTPRA 516-646 3.5e-19 63.9 In-house 48-179 (330) alignment 
Range on Protein: 516-646
Range on HMM: 48-179/330.0
GDCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG--SQRHYPSF
. .    . ||. ||| | ..| |..| .|....|.  .  ||||  .||. .| .|| .  ||. ||. || .|...  .|.| |..     .     .
atlelaskeenkeknrvvnilPydfsrvilsvkeGve.esdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

IHNKGKANYGPFIVEIMNYHQYPAMTSHMVKVM
  ..|   ||   ||. .     ..|   . | 
wPdeGlvtyGnirvevedetvlvdytvrkflvq
0040439 (Phosphotyrosine protein) phosphatases II 517-800 1.2e-44 148.2 In-house 2-247 (249) alignment 
Range on Protein: 517-800
Range on HMM: 2-247/249.0
DCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGeSKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQ------RHY
..  ....||. ||| . ..|.|| |..|. | |   .  ||||  .||. .| .||.| .| ..||..|| ..... ....|.|..          . .
eysvallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PSfihnKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPhqvppmkvdpegkgvskltfmisdimatgaqnqqiDAEVRICCVIQVRMWPiENKVPLSTT
|.    .|  .|| | |. ....... .|  .... .                                     | |.| . .||.  || . .|| |. 
pl....ggsleygdftvtllsvevkddytvrtleltnly...................................dgesrtvlhiqytdwp.dhgvppsfe

GLIDVIKMARSWRKRApdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYM
 |.| |...|......   |. .|..|....||.| |..|.| ....|..  ..||...|||..|  ||. . . . |..||...|....
dlldfieavrkaleel...pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 517-636 1.8e-18 61.7 In-house 39-159 (319) alignment 
Range on Protein: 517-636
Range on HMM: 39-159/319.0
DCAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGeSKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHY-PSFIH
.    .. ||. |||   ... |..|  |..|.| ... .||||  .||. .. .|| |  |.. |.. || ..... ...|| |..   . .   . ..
tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

NKGK-ANYGPFIVEIMNYHQYP
.. .  .|| .||.. . ..  
peenfeeyGrlivtleeeeele
subfamily_PTPRG_pd Subfamily PTPRG 518-801 6.2e-42 138.5 In-house 39-289 (563) alignment 
Range on Protein: 518-801
Range on HMM: 39-289/563.0
CAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN--QGSQRHYPSFIH
.   .. ||. |||.. .|. |..|  |. | |. |.. ||||  .||. .. .||.|  | ..|.| || .|...  ...| ..|  .  .|. . .  
aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWP

NKGKANYGPFIVEIMNYHQYPAMTSHmvkvmkrphqvppmkvdpegkgvsklTFMISDIMATGAQNQQIDAEVRiccVIQVRMWPiENKVPLSTTG-LID
. .  .|| . | ... ..    |..                          |..| ..     .... . .||     .   || .  || ...  || 
kdesetygalqvtlieeevlalytvr..........................tlviknlklkkkkqcdteklvr...qyhytkWP.dhgvPehslpvLif

VIKMarswrkRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMT
|.|        |  . |. |..|  ..||.| |.||  .  . |.  .. |.||. .|..| .|. |.  ...| .|.|..| . ..
vkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0037934 (Phosphotyrosine protein) phosphatases II 518-799 1.5e-36 121.5 In-house 2-242 (243) alignment 
Range on Protein: 518-799
Range on HMM: 2-242/243.0
CAGGHRLENRGKNRDVMVVPPDHARPYLqtlhgesKDYTYINAVEVDGFTRkaeFIVTEWPKQSTVDS----FWTLIYDHACHTVVNLSNQG------SQ
.. ....||. |||   ..| || | .|       ..  ||||  .... |   .|.| .| ..||..    || ..... ....|.| .          
fsiallpenlsknrysdilpydhsrvkl.......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

RHYPsfihnkGKANYGPFIVEIMNYHQYPAMTSHMVKVMkrphqvppmkvdpegkgvskltfmisdimatgaqNQQIDAEVRICCVIQVRMWPiENKVPL
. .|      |. .||.|.|......... .| ......                                  | ..| ..|  . ..   || ...|| 
qywp......gevtygdftvtllseehlddytvrtllle..................................nldlddltrlvihyhylpwp.dhgvPd

STTGLIDVIKMARSWRKR-----APDRPetKPTIVMSHNGVSRVGVYIGANICIDQMdidhEVDVFHAVKMMRINRPQ-LIDMKDEYKYLYDVMLHWY
|.. |.| ....|.. ..     | |.   .|..|. . ||.| |..| | ......    .||...|||..|  ||.  .   . |..||...|...
spedlldfldevrefieellsllaldsg..gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN6_pd Subfamily PTPN6 518-801 5.6e-25 83.0 In-house 46-299 (306) alignment 
Range on Protein: 518-801
Range on HMM: 46-299/306.0
CAGGHRLENRGKNRDVMVVPPDHARPYLQtlHGESKDYTYINAVEVDGF--TRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ---GSQRHYPS
   |.. ||. |||   ..| ||.|  |.  . . .. .||||  ...   . ....| |.   ..||  || ....  .. .| . ..   | .. .. 
rkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarY

FIHNKGKANYGPFIVEIMNYHqypamtshmvkvmkrphqvppmkvdpegkgvSKLTFMISDIMATGAqnqQIDAEVRICCVIQVRMWPiENKVPLSTTGL
. ... | .||   |. .. .                               |. .... ... .     . . | |     . . || .. || ..  .
WPdeeekeeyGkisvtnvsek...............................sladYilRelsvskk...kkkkeerevfqyhfksWP.dhgvpkdpgav

IDVIKMARSWRKRAPDRpETKPTIVMSHNGVSRVGVYIGANICIDQM---DIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMT
.| ..  .. ...  .. |. |..|   .|. | | .|  .| ....    .| ..|. ..||..|  | .|. ... ||..| .. ..  |
Ldfledvnrkqeeleea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 518-648 1.2e-11 39.0 In-house 36-168 (315) alignment 
Range on Protein: 518-648
Range on HMM: 36-168/315.0
CAGGHRLENRGKNRDVMVVPPDHARPYLQTLHgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ--GSQRHYPSFIH
   .   .|  |||   ..| |.||  |. .  .| |  ||||  . ..     .| .  |....|| || .....   |.| ....  | . .   .  
qrvaretinfkknryknilPldsarvklevid.dsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

N--KGKANYGPFIVEIMNYHQYPAMTSHMVkVMKR
.     ...| . ||... ..   ..   . |...
drkadsvefGsikvellsleadtdgvarkl.vtrk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 518-605 6.8e-11 36.7 In-house 25-107 (267) alignment 
Range on Protein: 518-605
Range on HMM: 25-107/267.0
CAGGHRLENRGKNRDVMVVPPDHARPYLQTLHGEskdytYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG
..     .|. .||   ..| |..|  |.|   |     ||||  |.|. .|  ||||. | . |.  |.|.| |. . ..| | . .
isqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 521-798 3.3e-30 99.9 In-house 41-282 (290) alignment 
Range on Protein: 521-798
Range on HMM: 41-282/290.0
GHRLENRGKNRDVMVVPPDHARPYLQTLHGESK-DYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ---GSQRHYpSFIHN
|   .|. .||   .|..|  |  |. . |.      ||||. ..|.  | ..|.|. | ..|.  || ||... .  .| | |    |... .  .  .
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCq.qYWpd

KGKANYGPFIVEImnyhqypamtshmvkvmkrphqvppmkvdpegKGVSKLTFMISDIMATGAQNQQidAEVRICCVIQVRMWPIENKVPLSTTGLIDVI
.. ..||.| ...                                   ..|. .|   .    .|..  .. ..    |.  |. . ||.  .| |. . 
sdtkaygefsikl................................lneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvie

KMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHW
.| .  |||       .. .|   ..|.| .|.. |.. |... ..  .|||. .| .|| .|...  ...|.......|. 
emyktqrkrg.....ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 521-650 7.5e-18 59.6 In-house 4-133 (250) alignment 
Range on Protein: 521-650
Range on HMM: 4-133/250.0
GHRLENRGKNRDVMVVPPDHARPYLQTLHgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN-QGSQRHYPSFIHNKGK
.....|. |||.  ... |..|  |.. .   |.  ||||. ..|.. .  ||.|  | |.|.  || .....   |.| |.| . |.. |. ..  .. 
akkpqnkeknryadiialdssrvvLekek.gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

ANYGPFIVEIMNYHQYPAMTSHMVKVMKRPH
 .||   |.... ...  .|.. .|. |. .
ekyGdvtvsllskeefadytkrklklskakk
subfamily_PTPN12_pd Subfamily PTPN12 521-602 9.8e-11 36.1 In-house 35-115 (290) alignment 
Range on Protein: 521-602
Range on HMM: 35-115/290.0
GHRLENRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS
|.. ||. |||   ..| |..|  |.. ..|  .  ||||  . | . | |.| .  |   |.| || .|...  . || . 
gekeenvkknrykDilPydksrvelskieeee.gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaC
0042113 (Phosphotyrosine protein) phosphatases II 522-799 3.3e-41 136.7 In-house 5-243 (245) alignment 
Range on Protein: 522-799
Range on HMM: 5-243/245.0
HRLENRGKNRDVMVVPPDHARPYLQtLHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS------QRHYPSfih
 ..||. ||| . ..| || | .|.  .|.. | .||||  |||. ..  ||.| .| ..||. || ..... ..|.|.|..         .. .|.   
llpenkdknrysdilpydhtrvkls.pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...

nKGKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPHqvppmkvdpegkgvskltfmisdimatgaqnqqidAEVRICCVIQVRMWPiENKVPLSTTGLIDV
 ... .|| |.|. ....... .|   ..| . ..                                    |.| .....   || ...|| ..  |.|.
.gesltygdftvtllseehlddytvrtlevtnlgd...................................desrevihyhylpwp.dhgvpdllellldf

IKMARSWRKRapdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWY
....|.....    .. .|..|... ||.| |..|.| ....|..  ..|....|||..|  ||. . . . |..||...|...
lefvrkalae....dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 522-647 4e-17 57.3 In-house 42-170 (305) alignment 
Range on Protein: 522-647
Range on HMM: 42-170/305.0
HRLENRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS---NQGSQRHYPSFIHNKG
.. .|. ||| . ... |. |  |.. . .  |  ||||  |||. || ..||.  | ..||. || ||..   .|.| |.   ..| .. .  ....|.
kkeankaknrlkeitlldddriiltekesld.dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

K-ANYGPFIVEIMNYHQYPAMTSHMVKVMK
.  ..|.|.||. . ....  .   .|. .
ekkefgefsvelksektasdyieRklkisi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 522-641 4.8e-17 56.8 In-house 45-164 (315) alignment 
Range on Protein: 522-641
Range on HMM: 45-164/315.0
HRLENRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ--GSQRHYPSFIHNKgK
.. ||. ||| . ... |..|..|  |  .. .  |.||  .||...|  .| .. |. ..|. || |.... . ..| |.|   | .|.   .  .| |
kkienkqknryiniiaydksrvqlpllendp.hsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.k

ANYGPFIVEIMNYHQYPAMTSH
  ||.. |  ..  ..  .|  
viyGkitvtrkseevnteytvr
subfamily_PTPRB_pd Subfamily PTPRB 522-648 3.6e-15 50.8 In-house 47-175 (293) alignment 
Range on Protein: 522-648
Range on HMM: 47-175/293.0
HRLENRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN---QGSQRHYPSFIHNKG
.. .|| |||   ..| ||.|  |..|..|| .  ||||  ..|.. . |||.|  |  .||| || ..... ....| | .   .| ..    . ... 
elavnraknrytnilpydhsrvkLaalkdes.gsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee

KANYGPFIVEIMNYHQYPAMTSHMVKVMKR
  .||   |.... ...   . . .|. |.
pvlyGdikvtlvaeeeledwvirelkieke
subfamily_PTPN1_pd Subfamily PTPN1 522-796 3e-13 44.2 In-house 28-268 (290) alignment 
Range on Protein: 522-796
Range on HMM: 28-268/290.0
HRLENRGKNRDVMVVPPDHARPYLQTlhgesKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN---QGSQRHYPSFIHNKG
.. |||..||   | | ||.|  |.      .|  ||||  |.    | ..|.|  |  .||| || ..... ...|| | .   ..... .  . ... 
klpenrnlnryrdvspydhsrikler.....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

----KANYGPFIVEIMNYHQYPAMTSHMVKVMKrphqvppmkvdpegkgvskltfmisdimatgaqnqQIDAEVRICCVIQVRMWPiENKVPLSTTGLID
    . .   . |.... ...   | ..... .                                   .   | |         || .  || | . ...
ekellledtklkvkliseerksyytvrllelen...................................lktqetreilhfhyttwp.dfgvpespaaflk

VIKMARswrKRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHE---VDVFHAVKMMRINRPQLIDMKDEYKYLYDVML
 .   |   .     ..  |...    |. | | .. .. |. ...  ..   ||. . .  .|  |  ||  .|  .. |  .|
flfkvr...esGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 522-634 3.4e-13 44.4 In-house 44-158 (325) alignment 
Range on Protein: 522-634
Range on HMM: 44-158/325.0
HRLENRGKNRDVMVVPPDHARPYLQTLHgESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQR-HYPSFIHNK-GK
 . ||. |||   ||. |..|. |.|.. .. .  ||||  .  . .|  |. .  |. .|.. .| |..|  |  || |     .  .   .  .. ||
mkpenkaknrfknvvaldksrvvletkk.ddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgk

-ANYGPFIVEIMNYHQ
  ..|.. |...   .
sktfGglevklrtiee
subfamily_PTPRN_pd Subfamily PTPRN 522-633 4.7e-11 36.9 In-house 52-165 (297) alignment 
Range on Protein: 522-633
Range on HMM: 52-165/297.0
HRLENRGKNRDVMVVPPDHARPYLQTLHGESKDyTYINAVEV-DGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS--QRHYPSFIHNKG
.. .|  |||   |.| ||.|  |..   ..|.  ||||  . |   |.. .| |. |  ||| .|| ..... .  .|||..      ..   .  ..|
kaeknvkknrskavlpydhsrvklkeeasaeks.dyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG

KANYGPFIVEIMNYH
.. |. . |...  |
sevyhiyevhlvseh
subfamily_PTPN3_pd Subfamily PTPN3 522-641 1.8e-09 31.9 In-house 37-158 (280) alignment 
Range on Protein: 522-641
Range on HMM: 37-158/280.0
HRLENRGKNRDVMVVPPDHARPYLQTlhGESkDYTYINAV--EVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN---QGSQRHYPSFIHN
.. ||  |||   ..| |..|  |.   .|. ||   | |  |... .    .|.|  | ..|.  ||...... ....| | .   .| .. .  . ..
rkpenlsknryrdilpydatrvklke..set.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPet

KGKANYGPFIVEIMNYHQYPAMTSH
. . .|| | |.. . ..  ..   
edeleygefsvkcekedetksyvlr
subfamily_PTPRK_pd Subfamily PTPRK 523-797 4e-42 139.1 In-house 40-275 (314) alignment 
Range on Protein: 523-797
Range on HMM: 40-275/314.0
RLENRGKNRDVMVVPPDHARPYLQTLHGESKDyTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQR--HYPSFIHNKGKA
. ||| |||   ....|..|. |.|..|...   ||||  .|...| |.||||  |.|.||  || |.||. | ..| |..  ..   .   .  .... 
kdenreknrsgdilaydrsrvflitidgdpss.dyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

nYGPFIVEIMNYHQYPAMTSHMVKVMKrphqvppmkvdpegkgvskltfmisdimatgaqNQQIDAEVRICCVIQVRMWPIEnKVPLSTTGLIDVIKMAR
 ||.. ||... .    . . . .| |                                  ..   |.|.   .|   ||   .|| | |||.....   
.ygdikvelvetellaelvvrifrvek.................................largqeeirevrqfqflgWpdh.dvPvsatgllklvrrvk

SWRKRapdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLH
....      |  ...|   .|  | |..|  .| .| .. .. ||||.||| .| ... ... .. ||..|||.| 
ksqee.....eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 523-801 1.1e-22 75.1 In-house 37-295 (301) alignment 
Range on Protein: 523-801
Range on HMM: 37-295/301.0
RLENRGKNRDVMVVPPDHARPYLQTLHG-ESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQ--RHYPSFIHN--K
. ||.  ||   ... |. |  |.. .  ...  .||||  .||...| .||... | ..|.  || ||...   ..| . |.  .   .   . .|  .
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

GKANYGPFIVEIMNYHQYPAMTSHMVKVMKRPHQVppmkvdpegkgvskltfmisDIMATGAQNQQIDAEVRICCVIQVRMWPIENKVPLSTTGLIDVIK
 . ..||| |...| . || ..   ..|. .                        .       . . | . .    .||  || .  |.   | |  . .
eseefgpftvtlvneqvyPdfvirqlnvkiqdgsn....................ngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

MARswRKRapdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMT
.    |..   ...  | .|   ..||| |||.  .| ..|   .  ||||  .| .| ..|  .   . |  .|||.  . . 
vih..rqq...kigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
0049772 (Phosphotyrosine protein) phosphatases II 523-798 3.8e-19 65.0 In-house 43-279 (314) alignment 
Range on Protein: 523-798
Range on HMM: 43-279/314.0
RLENRGKNRDVMVVPPDhARPYLQTLHGESKDytYINAVEVDGFtrkAEFIVTEWPKQSTVDSF----------WTLI--YDHACHTVVN----------
 ..|| |||   ..| |  |  |..|.... |  ||||  ||||     ||.|..|.. ||..|          |...  .|. ....|           
lflnrdknryldilpad.nrvilpglpvsgsd..yinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LSNQGSQRhypsfihnkgkanygpfiveimnyHQYPAMTSHMVKvmkrphqvppmkvdpegkgvskltfmisdimatgaqNQQIDAEVR
           | .   .                          ...|..  . |                                    . . |.|  
srLdaAlgKtpllildgng........................neptaadlellk....................................eelydpelf

ICCVIQVRMWPIENKVPLSTTGLIDVIKMARSWrkrapdrPETKPTIVMSHNGVSRVGVYIGANICIDQMdidhEVDVFHAVKMMRINRP-----QLIDM
   .|..  .|..   . ..  . ..... ...       .. .|..|  . |..| |... | ... ..     |..  |....|  ||      .| .
erlgikylripvpDgsaplledfdeflefieea.......dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieq

KDEYKYLYDVMLHW
 ..| . ....|..
leqyefilealley
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 523-604 2.9e-11 38.0 In-house 38-118 (281) alignment 
Range on Protein: 523-604
Range on HMM: 38-118/281.0
RLENRGKNRDVMVVPPDHARPYLQTlHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ
. ||. ||| . .|  |..|  ..  . |.|.  ||||  |.|.. ..|.|.|. |  .....|| ...... ...| . ..
adenvlknrYsnivaYDatrvkvtp.neenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtre
subfamily_PTPRD_pd Subfamily PTPRD 524-797 2.7e-42 140.1 In-house 46-279 (564) alignment 
Range on Protein: 524-797
Range on HMM: 46-279/564.0
LENRGKNRDVMVVPPDHARPYLQTLHGEsKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG--SQRHYPSFIHNKGKAN
 .|. |||   .|. || |  |....|. ..  ||||  .||.... ..| |  |...|.. || ..... ..|.| |..    ..  . ..  .||...
paNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtet

YGPFIVEIMNYHQYPAMTSHMVKVmKRPHqvppmkvdpegkgvskltfmisdimatgaqnqqiDAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARS
|| ..|.... ...  ..    |. |. .                                  . |.|     .   || .. || |.|.|.|.|.  |.
ygeltVtleeeeeladyeirtfkl.kkkk..................................ssesreVrqFhFtsWP.dhgvpesatslLdlirkvra

WRKrapdrPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLH
...     |...|..|   .|| | |..|  .......  .. ||..  ||..| .|. ... .. | ......|.
lne.....pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 525-797 3.8e-22 73.5 In-house 32-264 (283) alignment 
Range on Protein: 525-797
Range on HMM: 32-264/283.0
ENRGKNRDVMVVPPDHARPYLQTLHGeskdyTYINAVEVD---GFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN--QGSQRHYPSFIHNKGK
||. |||   .|| |  |  |...       .||||| .       .. ..|..  | . ||  || ...|.   ..| |..  .. . .   .  ..| 
enkrknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs

ANYGPFIVEIMNYHQYPAMTSHMVKVMKRphqvppmkvdpegkgvskltfmisdimaTGAQNQQIdaevriCCVIQVRMWpienkVPLSTTG----LIDV
 .||.| | . .     ... . . . .                             . |... .       .  ||  |     .  .       |. .
edyGeftvtlrkettsnsfiikelllrvn............................ssakstll......lahyqvidW.....leygeqaiinslvkf

IKMArSWRKRApdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLH
 |.  | ...     .  | .|   .|. | .|.|.|   ....  .  ||||  ||.|| .|. ..  .| || .....| 
nkvi.slqtes....kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 525-656 7.9e-17 56.2 In-house 46-174 (287) alignment 
Range on Protein: 525-656
Range on HMM: 46-174/287.0
ENRGKNRDVMVVPPDHARPYLQtlhGESKDytYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ--GSQRHYPSFIHNKGKANY
.|. |||   ...||  |  |.   || .|  ||||| .||.  | .||..| |  .|.  || || |.  ...| |...    ..    .  ..    .
qnkdknRltqilvpdnyrvllk...gehpd..yinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvl

GPFIVEIMNYHQYPAMTSHMVKVMKRPHQVPPMK
|.. .|..| ...  ..   ..| .. .. .. .
Geyniellneevnagyierklevknknkagdkqq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 525-623 4e-15 51.1 In-house 24-117 (284) alignment 
Range on Protein: 525-623
Range on HMM: 24-117/284.0
ENRGKNRDVMVVPPDHARPYLQTLHGESKdYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHYPsfihNKGKANYG
.|. ||| . ... |...  |. | ||     ||||  . |. ||  .| |  |.. |.. || .|... | |.| |...   ...|    .|.. ...
qnkdknrighilafdknvvklerliGeef.sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdkcsqywp....lkivikee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 525-616 4.9e-15 50.6 In-house 60-150 (319) alignment 
Range on Protein: 525-616
Range on HMM: 60-150/319.0
ENRGKNRDVMVVPPDHARPYLQTLHGESKdYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHYPSFIHN
.|. ||| . ... |...  |. | ||     ||||  |.|. ||  .| .  |.. |.. || .|... | |.| |...   ...|  |  
qnkdknriinilafdknvvklerliGeef.sdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkdkcsqywplkivi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 525-602 1.4e-10 35.4 In-house 37-112 (287) alignment 
Range on Protein: 525-602
Range on HMM: 37-112/287.0
ENRGKNRDVMVVPPDHARPYLQtlHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS
 .  |||   |.| |..|  |   .   .   ||||  | ..|.. .||..  |  .|| .||......   .|. ..
aavkknryadvlPiddtrvlls..aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmt
subfamily_PTPN9_pd Subfamily PTPN9 525-602 5e-10 33.9 In-house 41-117 (297) alignment 
Range on Protein: 525-602
Range on HMM: 41-117/297.0
ENRGKNRDVMVVPPDHARPYLQTLHGESKdYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS
 |  |||   |.  |..|  |........   ||||  |||. .|  || |  | . ||. || ..... . ..|   
anleknrytdvlcydetrvvlakvdedea.sdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 525-645 1.2e-07 26.2 In-house 2-123 (237) alignment 
Range on Protein: 525-645
Range on HMM: 2-123/237.0
ENRGKNRDVMVVPPDHARPYLQtlhGESKDYTYINAVEVDGFTRK-AEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN---QGSQRHYPSFIHNKGKA
||. |||   .|  ||.|  |.   |   .  ||||  ..||     ..| .. | .|. | || ....  |  .| |.    .  .. .  .   .  |
enkiknrygnivaydhsrvvlk...gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

NYGPFIVEIMNYHQYPAMTSHMVKV
 || . | .    ..   |   . .
aygvltvslkkkeefsdytvrslll
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 525-602 9.7e-07 22.6 In-house 95-169 (244) alignment 
Range on Protein: 525-602
Range on HMM: 95-169/244.0
ENRGKNRDVMVVPPDHARPYLqtlHGESKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS
.|  |||.   .| |  |  |      |   |||||  |  . | ||.|.|. |   |   || .. .     .| | 
nnswknregaglpfdfnrvpl...skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg
Y_phosphatase Protein-tyrosine phosphatase 526-796 3.3e-42 139.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 526-796
Range on HMM: 1-234/235.0
NRGKNRDVMVVPPDHARPYLQTLHGESKdytYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS--QRHYPSFIH--NKGKAN
|. |||  ...| |. |  |.   |.|.   ||||  |.|...| .||.|. | .||...|| ..... ....| | .     ..... .    .... .
nkkknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGPFIVEIM-NYH-QYPAMTSHMVKVMKRPHQVppmkvdpegkgvskltfmisdimatgaqnqqidaEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMA
|| . ||.. . . .  ..| . ... |. ..                                   | |.  ....  || ...|| |...|.|.|.. 
ygdikvelkekekedekeytlrklelkkkkees..................................ekrevkqlhytnWp.dhgvpespkslldlirkv

RSWRkrapdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVML
....     .....|..|.. .||.| |... ..|...|.. ..||||...||..| .||....  ..|..||...|
eksk.....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 526-796 3.3e-42 139.9 In-house 1-234 (235) alignment 
Range on Protein: 526-796
Range on HMM: 1-234/235.0
NRGKNRDVMVVPPDHARPYLQTLHGESKdytYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS--QRHYPSFIH--NKGKAN
|. |||  ...| |. |  |.   |.|.   ||||  |.|...| .||.|. | .||...|| ..... ....| | .     ..... .    .... .
nkkknRykdilpydktrvklkgsegpsd...YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGPFIVEIM-NYH-QYPAMTSHMVKVMKRPHQVppmkvdpegkgvskltfmisdimatgaqnqqidaEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMA
|| . ||.. . . .  ..| . ... |. ..                                   | |.  ....  || ...|| |...|.|.|.. 
ygdikvelkekekedekeytlrklelkkkkees..................................ekrevkqlhytnWp.dhgvpespkslldlirkv

RSWRkrapdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVML
....     .....|..|.. .||.| |... ..|...|.. ..||||...||..| .||....  ..|..||...|
eksk.....eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 526-802 9.6e-26 85.9 In-house 1-174 (182) alignment 
Range on Protein: 526-802
Range on HMM: 1-174/182.0
NRGKNRDVMVVPPDHARpylqtlhgeskDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSnqgSQRHYPsfihnkgkanygpf
|. ||| . ..|.|| |           |..||||  ..|  .  .||.| .| .||| .|....... ..|.|||.   . ...|              
nldknrysdilpydhsr...........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywp..............

iveimnyhqypamtshmvkvmkrphqvppmkvdpegkgvS-KltfmisdimatgaqnqqidaevrICCVIQVRMWPIENKVPLSTTGLIDVIKMARSwrk
                                       .                          . .||.. .|..   . ..  |.| |.....   
.......................................ell.......................erlgiqylylpwpDhgvpdldelldfieevle...

rapdrpETKPTIVMSHNGVSRVGVYIGANICIDQmdidhEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMTN
      | .|..|  . ||.| |....| ... .     .|....|||..|  ||. . . . | .|....|.... .
......eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 526-646 2.9e-16 54.4 In-house 46-167 (318) alignment 
Range on Protein: 526-646
Range on HMM: 46-167/318.0
NRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG--SQRHYPSFIHNKGKANYG
|. ||| . ... ||.|  ||.|.||  .  ||||  .||..|| ..| .  |   |.. || ....  . ..| |...   ...    .  .||  .||
nkaknryanilaydhtrvkLqmlegee.gsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg

PFIVEIMNYHQYPAMTSHMVKVM
   ||...  ..  ..   .|| 
klvvelkeevelsdyvlrefkvt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 526-643 1.9e-11 38.7 In-house 51-166 (297) alignment 
Range on Protein: 526-643
Range on HMM: 51-166/297.0
NRGKNRDVMVVPPDHARPYLQTLhGESKDYTYINAVEVDGFTRkaEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQG-SQRHYPSFIHNKGKANYGP
|  |.|   ..| |  |  |. . ... |  |.||  | |.    ..| |. |...||. ||....|.   |.| |...  ....   .  .|| ...| 
nfeksRYkniLPydssRvkLaiv.nddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGd

FIVEIMNYHQYPAMTSHMV
  |...  ..   .    .
vsvvllsvsereGfikrel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 526-602 6.3e-08 26.9 In-house 20-96 (270) alignment 
Range on Protein: 526-602
Range on HMM: 20-96/270.0
NRGKNRDVMVVPPDHARPYLQTLHGESkDYTYINAVEVDGFT-RKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLS
..  ||   ..|  ..|  |..|. .|   .||||  | ||. .|...| .  |...|. ||| .|...  ...| ..
gkklnRyadiLPsPatRvrleeleeds.ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmtt
subfamily_egg_pd Subfamily egg 526-611 2e-07 25.0 In-house 40-124 (307) alignment 
Range on Protein: 526-611
Range on HMM: 40-124/307.0
NRGKNRDVMVVPPDHARPYLQTLHGESKDyTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHYP
|. | |. .|   | .|  |.  .|   |  .| |  |.|     |||... | . ||| || ...   .. .| |. .    . .
nlekarskrvhckdssrvklelrrGqyld.dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserce
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 527-798 1.8e-24 81.3 In-house 29-267 (274) alignment 
Range on Protein: 527-798
Range on HMM: 29-267/274.0
RGKNRDVMVVPPDHARPYLQTLHGESKDYTYINAVEVDGFTRKA-EFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGS------QRHYPSFIHNKGK
  |||   ..| ...|  |.. ..|..| .||||  . |. ..   .. |  | ..||. || .|| . .. .| | .         ....|  .. . .
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

ANYGPFIVEIMNYHQYP--AMTSHMVKVMKRPHQvppmkvdpegkgvskltfmisdimatgaqnqqidaevriCCVIQVRMWPiENKVPLSTTGLIDVIK
 .|| . ... .  .     ... ..| ..|...                                       .  .    || ..|.| ... |.|...
erygdveikvekiverndysvrklvlkylerers.......................................vkhywytdWP.dhksPddantlldlvl

MARSWRKRapDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHW
  .. |..  .  .. |..|    |. | |..|...|.. |.. .. |||.. |  .|..|  ... .. |.... .. ..
eveesree..enaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 527-647 2e-13 44.6 In-house 49-165 (439) alignment 
Range on Protein: 527-647
Range on HMM: 49-165/439.0
RGKNRDVMVVPPDHARPYLQTLHGESKDyTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQ-GSQRHYPSfihnKGKANYGPF
. |||   |.. ||.|  || . |  .   ||||  ..|.  .  .| |. ||. |.|.|| |.... . |.|.|.|   | ...||    .... ||  
qtknrykdvgafdhtrvtlqeipgvphs.hyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesykywps....daevcygdi

IVEIMNYHQYPAMTSHMVKVMK
.| .    . |  . . .||..
avrvdrnielpnyvirgfkvfn
subfamily_PTPN23_pd Subfamily PTPN23 527-608 5.2e-12 40.2 In-house 44-121 (288) alignment 
Range on Protein: 527-608
Range on HMM: 44-121/288.0
RGKNRDVMVVPPDHARPYLQtlhgESKDyTYINAVEVDGFTRKA-EFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQR
  |||   ..| ||.|  |.    .|||  ||||  | . .  . .||.|  |.|||.  || ..|.    ..| | ..  . 
seknrsrdilPyDhnRvklr....gskD.DYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 528-797 5.9e-12 40.1 In-house 35-293 (297) alignment 
Range on Protein: 528-797
Range on HMM: 35-293/297.0
GKNRDVMVVPPDHARPYLQTLHGEsKDYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVV---NLSNQGSQRHYPSFIHNK-GKANYG
 |||   ..  | .|  |.    | .||   . |       .  .|... | ..||| ||||....   ..|   .| ..| .. .| . . . .. . |
rknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

PFIVEIMNYHQYPAMTSHMvKVMKRPHQvppmkvdPEGKG---VSKLTFMISDIMATGAQNQQIDAEVRICCVIQVRMWPIenkVPLSTTGlidVIKMAR
 ..|| .        . ..   ..  ..        | .    |  |..    . .   . .. .|.|  ||.    |  .   | . |.    |.    
dvvveflsstsdefdrvil.telqliyr.......sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlal...vemftam...vflqle

SWRKrapDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLH
| |    . |   ...|    || | || . ... ....  ..  ||   ....| .|..|.   .....|||..|.
slra...emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
0044763 (Phosphotyrosine protein) phosphatases II 541-799 3.7e-12 41.7 In-house 5-171 (178) alignment 
Range on Protein: 541-799
Range on HMM: 5-171/178.0
ARPYLQTLHGEsKDYTYINAVEVDGFtrkaeFIVTEWPKqstvDSFWTLIYDHACHTVVNLSNQGSQRH---YPSFIHNKGkanygpfiveimnyhqypa
 |  |..| |.   . ||||.|....     .... .|      ... |.... ....|||..     .   .| .  . |                   
trvllsnlegl.ersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

mtshmvkvmkrphqvppmkvdpegkgvskltfmisdimatgaqnqqidaevriccvIQVRMWPIENKVPLS-TTGLIDVIKMARSWRKRAPdrpetKPTI
                                                        ||.. .||.   . . .  . ..... ...... .     .|..
........................................................iqylhipipDhgvpdllehflefvefieealdekg.....gpvl

VMSHNGVSRVGVYIGANICIDQmdidhEVDVFHAVKMMRINRPqLIDMKDEYKYLYDVMLHWY
|  . ||.| |. . | ... .      .....|....|  ||  .   . ...||.. |...
VHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyefelrll
0046846 (Phosphotyrosine protein) phosphatases II 549-798 1.1e-15 53.3 In-house 6-172 (176) alignment 
Range on Protein: 549-798
Range on HMM: 6-172/176.0
HGESKDYTYINAVEVDGFtrkaEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHY-----PSFIHNKGKanygpfiveimnyhqypamtshmv
.|.  |..||||  ..|      .|.| .|  .|. .|. ..... ...|||| .     ..     .. ... |                         
lgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

kvmkrphqvppmkvdpegkgvskltfmisdimatgaqnqqidaevriccviQVRMWPIENKVPLSTTGLIDVIKMARSWRKRApdrpetKPTIVMSHNGV
                                                   |.  .|..   . . . |...... |...|.       .|..|  . |.
...................................................qylhlpwpDhgvpdlelllellefirealkeg......gpvlVHCsaGi

SRVGVYIGANicidQMDIDHEVDVFHAVKMMRINRP-QLIDMKDEYKYLYDVMLHW
.| |... |      .  .. ..|..|....|  || . .   . |..||...|..
gRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 554-793 1.1e-16 56.6 In-house 4-155 (172) alignment 
Range on Protein: 554-793
Range on HMM: 4-155/172.0
DYTYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQgsqrhypsfihnkgkanygpfiveimnyhqypamtshmvkvmkrphqvp
. .||||  .|.     .||.| .| ..|...|| ..... ....||| .                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

pmkvdpegkgvskltfmisdimatgaqnqQIDAEVRICCVIQVRMWPIENKVPLSTTGLIDVIKMARSWRKRAPdrpeTKPTIVMSHNGVSRVGVYIGAN
                             . |.|     .||.  .|..   . ..  |.....  ...  . |     .|..|  . ||.| |. . | 
.............................lydpellerlgiqylylpwpDhgvpllellleflefidellalsp....ggpvlVHCsaGvgRtgtlvaay

ICIdqmdidHEVDVFHAVKMMRINRPQLIDMKDEYKYLYD
...      . .....||...|  ||. .  .. |..||.
lml......lglsleeavalvrekRpgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 556-793 4.1e-21 70.9 In-house 3-164 (174) alignment 
Range on Protein: 556-793
Range on HMM: 3-164/174.0
TYINAVEVDGFTRKAEFIVTEWPKQstvdsFWTLIYDHACHTVVNLSNQGSQRHYPSFIHNKGkanygpfiveimnyhqypamtshmvkvmkrphqvppm
.||||  .|.. .  ..|.. .| .     || ..... ..|||.| .     .|  .                                          
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

kvdpegkgvskltfmisdimatgaqnqqiDAEVRICCVIQVRMWPIENKVPLSTTGLIDVIKMARSWRKRapdrPETKPTIVMSHNGVSRVGVYIGANIC
                             . |     .||.  .|..   . ... |....| .......    .. .|..|  . ||.| |. ..| ..
.............................lredlerlgiqylylpwpDhgvpdlsillefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylm

IDQMDiDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYD
. ..     ||... |...|  ||. . . . |..||.
lrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 556-800 8.7e-16 53.8 In-house 5-226 (272) alignment 
Range on Protein: 556-800
Range on HMM: 5-226/272.0
TYINAVEVDGFTR---KAEFIVTEWPKQSTVDSFWTLiYDHACHTVVNLSNQGSQRHYPSFIHNkgkanygPfiveimnyhqypamtshmvkvmkrphqv
.||||  |.|..|   .  .. .  | . |...||.| ... ..|.|.| .   . ... . .        |                            
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.......p............................

ppmkvdpegkGVSKLTFMISDIMATGAQ-------------------------NQQIDAEVRICCVIQVRMWPIENKVPLSttgLIDVIKMARSwrkrap
          |.  | . | | .|.                            ..    |.|   ... . ||  .  . .   |...... ..      
..........girylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea...llellellld......

drpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVD--------VFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYM
     .| .|  . |..| |... . ... ... .  ||        ...||...|  ||. .   . |..||...|....
....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 556-794 1.1e-13 46.5 In-house 4-148 (151) alignment 
Range on Protein: 556-794
Range on HMM: 4-148/151.0
TYINAVEVDGFtrkaeFIVTEWPkqstVDSFWTLIYDHACHTVVNLSNQGSQRHYPSFIHNKGkanygpfiveiMNYHQYPAMTSHMVKvmkrphqvppm
.|||.  |.|.     .... .|     . |. |.... . |.||| .     ..|.. .. |           ......| .  .  .           
dyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeergycpeylpelg...........ievlhipildwpdpg...........

kvdpegkgvskltfmisdimatgaqnqqidaevriccviqvrmwpienkVPLSTTGLIDVIKMARSwrkrapdrPETKPTIVMSHNGVSRVGVYIGANIC
                                                 .|||.  ..........        .. .|..|  . |..| |. ... ..
.................................................lplsfdavleflellld........kkngpvlvHCsaGkgRTGtlvalylm

IdQMdidheVDVFHAVKMMRINRPQLIDMKDEYKYLYDV
. ..     |... |....|. || ..  .... ... .
l.lg.....vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 556-800 1.6e-06 22.4 In-house 68-271 (288) alignment 
Range on Protein: 556-800
Range on HMM: 68-271/288.0
TYINAVEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSN------QGSQRHYPSFIHNKGKanYGPFiveimnyhqypamtshmvkvmkrp
 ||.|  |     |  .| .. | ..|.. .| .. .   . .| |..      . |. ..|| . .| .  .| .                        
fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar..igrl........................

hqvpPMKVDPEGKGVSKLTFMisdimATGAQNQQIDAEVrICCVIQVRMWPiENKVPLSTTGLIDVIKMArswrkrapdRPETKPTIVMSHNGVSRVGVY
       |  . ... ||  .     ..   ..... .| |  .. .. |. .. || .    . ....          .  .|| .|.|..|| | |  
....ctvvkkkradidklvkv.....sllriskegeekv.ivkilhlleWd.ddgvPenylsplrllevl.........kslqkPivvhssaGvGrtgtl

IGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMlHWYM
|   | .... .|  . . . .. .| .| . |  .  | |.. .. . ..
ililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv.leel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 561-627 1.1e-06 22.3 In-house 227-293 (440) alignment 
Range on Protein: 561-627
Range on HMM: 227-293/440.0
VEVDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHYPSFIHNKGKANYGPFIV
 |..|...|  || |. | .|||  || |..|.   |.. | .   .     .  |     .||| |
qefegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftv
0049260 (Phosphotyrosine protein) phosphatases II 563-793 1.2e-13 46.5 In-house 2-144 (152) alignment 
Range on Protein: 563-793
Range on HMM: 2-144/152.0
VDGFTRKAEFIVTEWPKQSTVDSFWTLIYDHACHTVVNLSNQGSQRHYPSFIHNkgkanygpfiveimnyhqypamtshmvkvmkrphqvppmkvdpegk
.||. .. ||| |..|   |...|| ..... ..|.|.| .     ..    .                                               
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

gvskltfmisdimatgaqnqqidaevriccviQVRMWPIENKVPLSTTGLIDVIKMARSWRkrapDRPETKPTIVMSHNGVSRVGVYIGANICIdqmdid
                                |.  .|..   . . . |.. .  .  ..     . . .|..|  . ||.| |... | ...      
................................qylhlpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaaylml......

HEVDVFHAVKMMRINRPQLIDMKDEYKYLYD
. |....||...|  ||. .  .. ...||.
lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPRA_pd Subfamily PTPRA 669-801 4.9e-16 53.5 In-house 171-297 (330) alignment 
Range on Protein: 669-801
Range on HMM: 171-297/330.0
FMISDIMATGAQNQQIDAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRapdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVF
. . ... .   ... . ..|.   .  . || .  ||  . |.....|  .. ...     .. | .|    || | | .|  .  ....  .. ||||
ytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkklnqq.....sagpivvhcsaGvGrtGtfivldavlervkaerkvdvf

HAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMT
..|| .| .|||..  .  |...| |.|..|. 
efvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 674-793 2.4e-07 25.1 In-house 122-235 (239) alignment 
Range on Protein: 674-793
Range on HMM: 122-235/239.0
IMATGAQNQQIDAEVRICCVIQVRMWPiENKVPLSTTGlidVIKMARSWRKRApdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKM
|. |   .|  ..| |     .. .|| .. ||  .|    |. . |   | .   | ..| ..    || | | ..  .  . |   .. ||.|  || 
iirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyata...vlglrrkitkds..lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvka

MRINRPQLIDMKDEYKYLYD
.| .||....  ..| ... 
iredrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 674-793 2.4e-07 25.2 In-house 121-234 (239) alignment 
Range on Protein: 674-793
Range on HMM: 121-234/239.0
IMATGAQNQQIDAEVRICCVIQVRMWPiENKVPLSTTGlidVIKMARSWRKRApdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKM
|. |   .|  ..| |     .. .|| .. ||  .|    |. . |   | .   | ..| ..    || | | ..  .  . |   .. ||.|  || 
iirtfvmsqvgqteeryvyqyhftvwp.dkgvpqyata...vlglrrkitkds..lpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvka

MRINRPQLIDMKDEYKYLYD
.| .||....  ..| ... 
iredrphmvqtseqyvfihl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 681-799 2.5e-18 61.2 In-house 172-283 (319) alignment 
Range on Protein: 681-799
Range on HMM: 172-283/319.0
NQQIDAevRICCVIQVRMWPiENKVPLSTTGLIDVIKMARswrkRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQ
......  |     |   || ...|| ..|.|.|..|  |    .. .... .| .|   .|| | | .|  .. ....  .  .|||. |...|. |. 
ssevet..RevkhfqyteWp.dhdvPekatslldllkrir....ksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRni

LIDMKDEYKYLYDVMLHWY
... .. ||..|...|.. 
mvqrpeqYkfiyealleav
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 681-798 1.8e-17 58.4 In-house 170-282 (305) alignment 
Range on Protein: 681-798
Range on HMM: 170-282/305.0
NQQIDAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRApdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQ
... | | |     |.  || .. || ..| |...||  .  .|.     . .| .|   .||.| ||.|  .| ....  . .||||. .| .| .|..
iededkesrtvlqyqltdWP.dhGvpqfatsllslikrvqkdqkkd....kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmk

LIDMKDEYKYLYDVMLHW
..  .|.| .|.|..   
mvqtldqYvflhdaldel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 682-796 2.4e-10 35.0 In-house 126-236 (237) alignment 
Range on Protein: 682-796
Range on HMM: 126-236/237.0
QQIDAEVRICCVIQVRMWPiENKVPLSTTGLIdviKMARSWRKRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQL
..   |||.    |   || .. ||  |. |.   .. .   .|.|  .|. | |.    || |.|...  .  . |    . ||..  |. .  .|| .
rltlkevrlihqyqftswp.drgvpqqtaall...rfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyi

IDMKDEYKYLYDVML
|. ||.| ......|
iqtkdqyvfihqtil
subfamily_PTPN12_pd Subfamily PTPN12 683-797 4.8e-12 40.4 In-house 164-275 (290) alignment 
Range on Protein: 683-797
Range on HMM: 164-275/290.0
QIDAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKrapdrPETKPTIVMSHNGVSRVGVYIGANICIDQM---DIDHEVDVFHAVKMMRINRP
. . | |.   .. . || .  || |.. |...|...|. ..      | .| .|    || | |. |  ..  ...    |..|.|||. |  .| .|.
eaqkesrkvyqfhYtaWP.DhgvPssaksllelielvrelqe.....sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqra

QLIDMKDEYKYLYDVMLH
 |.  |. |...|  ...
alvqtkeqyelvykavae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 684-804 2.3e-08 28.2 In-house 160-282 (287) alignment 
Range on Protein: 684-804
Range on HMM: 160-282/287.0
IDAEV---RICCVIQVRMWPIENKVPlSTTGLIDVIKMARSWRKRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQ
||.|    |.   ...  || .   | .. |||  .   .   . | |  |. | .|    |. | |...   ......    .|||  .|  .|  |  
idletrearvvkqldllswPdkvlaP.tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraa

LIDMKDEYKYLYDVMLHWYMTNPD
|.     ...||. .  .| |||.
lvqavvqlrllyealvtyyktnpq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 685-799 6.6e-18 59.8 In-house 171-280 (318) alignment 
Range on Protein: 685-799
Range on HMM: 171-280/318.0
DAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKrapdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDM
  |.|.    ..  || .. || |...|.|... .... .    .....|..|    || | ||.|  .| ....  .  ||||. ||..| .|. ..  
eeesrqvrqyhytsWp.degvpesgaslldlvrqvskaqq....ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

KDEYKYLYDVMLHWY
.| |...|||.|   
edqyefiydvlleal
subfamily_PTPN3_pd Subfamily PTPN3 685-800 4.7e-13 43.7 In-house 167-276 (280) alignment 
Range on Protein: 685-800
Range on HMM: 167-276/280.0
DAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRkrapdRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDM
  | |    .|   || ...|| ... ......  |. |     . ...|..|    |. | ||.|  ....  ... ..| . . |..||  |  |.. 
tkeerkilqlqylaWp.dhgvPddsadflefvervrklr.....sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqt

KDEYKYLYDVMLHWYM
.. ||.. . .|. |.
asqykfvCeailkvye
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 685-798 2.9e-09 31.5 In-house 166-275 (281) alignment 
Range on Protein: 685-798
Range on HMM: 166-275/281.0
DAEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRAPDrpetKPTIVMSHNGVSRVGVYIGANICIDQMDID-HEVDVFHAVKMMRINRPQLID
..| |    ..   || .. || .|. |..  |  .. ...  .     | ..    || | |.||. .  ..... . .|.||   |. .| .|  .. 
sgetreveqlaytaWP.dhGvPattkellefrkevlkltekktk....aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvq

MKDEYKYLYDVMLHW
    |...| ..|. 
tvvqyefvykavlda
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 686-801 5.6e-18 60.2 In-house 182-292 (298) alignment 
Range on Protein: 686-801
Range on HMM: 182-292/298.0
AEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRAPDrpetKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMK
.. |  . ...  || .. ||  .| ..|...  | ....| .    || ||   .|| | | .|  .  .... ... ||||..||..|..||.... .
ekerevrqlhftsWp.dkgvpenatsvldllrkvrasqqqagn....kpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqte

DEYKYLYDVMLHWYMT
..|...|...|.   .
eqYvfiyeavlealds
subfamily_PTPN9_pd Subfamily PTPN9 686-799 4.7e-11 37.3 In-house 170-290 (297) alignment 
Range on Protein: 686-799
Range on HMM: 170-290/297.0
AEVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRA--------PDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRIN
 | |     |.  || .  || |.. |.||....|. .  |          .|.  | .|    |. | | .|  .||.....    |||...||..|  
eesrkvthfqflsWP.dyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtq

RPQLIDMKDEYKYLYDVMLHWY
|   | . . |.. |  .| . 
rafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 687-800 9.8e-16 52.5 In-house 173-280 (315) alignment 
Range on Protein: 687-800
Range on HMM: 173-280/315.0
EVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRAPdrpetKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKD
..|    ...  || . .|| .|. |...|. .. ... .       . .|  ..|| | | .|  .  .||..... .||..... .| || ..... .
nirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv.....gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvae

EYKYLYDVMLHWYM
.|...||..|  ..
qyqfiydalletfv
subfamily_PTPN14_pd Subfamily PTPN14 687-798 5.9e-13 43.5 In-house 181-295 (300) alignment 
Range on Protein: 687-798
Range on HMM: 181-295/300.0
EVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRAPDRPE----TKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLI
| |    .|   || ...||   .| .. ... .| |... .  |      | .|   .|| | || | ... |  .. ..|.|. ......|  |  |.
eertvwhlqytDWp.dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllv

DMKDEYKYLYDVMLHW
.    ||..|.|....
qtlaqYkfvYkvliky
subfamily_PTPN23_pd Subfamily PTPN23 687-797 2.6e-07 24.8 In-house 169-278 (288) alignment 
Range on Protein: 687-797
Range on HMM: 169-278/288.0
EVRICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRApDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHE-VDVFHAVKMMRINRPQLIDMK
.|.  . .|.  || |  || |   |..... ..|  .    |.  .| .|    || | ||.      . ... ..  .|. . |. .| .|   .  |
avksvshlqltsWp.elGvPasPetllqfldevesayeav.qrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqek

DEYKYLYDVMLH
...| .|...|.
eqlkfsyeavle
0048179 (Phosphotyrosine protein) phosphatases II 688-793 8.2e-08 27.6 In-house 44-139 (144) alignment 
Range on Protein: 688-793
Range on HMM: 44-139/144.0
VRICCVIQVRMWPIENKVPLST-TGLIDVIKMARSWRKrapdrpETKPTIVMSHNGVSRVGVYIGANICIdqmdiDHEVDVFHAVKMMRINRPQLIDMKD
  .. .||.  .|...  . .  . |...... .....      | .|..|  . ||.| |... | ...      . .....|....|  ||. .   .
fleregiqylhlpwpDhgvpdllellleflefieeale......eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg

EYKYLYD
 ...|..
qlrfLle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 689-817 2.1e-12 42.1 In-house 149-279 (284) alignment 
Range on Protein: 689-817
Range on HMM: 149-279/284.0
RICCVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRAPDRpetKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEY
|       . || .  || ... |. ..|  |  ...  .|   .. .|    || | ||||  .. .|.|. .. |||.. |. .| .|..|..   .|
rkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhr...anivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

KYLYDVMLH------WYMTNPDYRIYDKEDSEDTD
|..|  .|         .. ||.  | .| |...|
kfiysalleehlfghsdvalpdfpayleelsnksd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 690-801 2.2e-10 34.5 In-house 182-287 (302) alignment 
Range on Protein: 690-801
Range on HMM: 182-287/302.0
ICCVIQVRMWPiENKVPLSTTGLIDVIKMArswrkRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYK
.. |  . .|. ..||| . . ||  ..        | . . ...|...|.||. | |. . . . ..... ..|. .   || .| .||. .|  . | 
lanvyvltnWk.qkkvpvkyaeliktaakv.....fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyv

YLYDVMLHWYMT
 || ..| .  .
slyialllyikk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 692-797 1.1e-15 52.4 In-house 176-275 (315) alignment 
Range on Protein: 692-797
Range on HMM: 176-275/315.0
CVIQVRMWPiENKVPLSTTGLIDVIKMARSWrkrapDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYL
   | . || .. |.  |. |. .||  ..      ..... . .|    || | || | .. ...|.   . ||||. ||..| .||.|.  ..|| ..
tqfqftewP.dkGvdkqtssllklikevkad.....ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafi

YDVMLH
||..| 
ydavle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 692-797 1.2e-13 45.0 In-house 175-274 (515) alignment 
Range on Protein: 692-797
Range on HMM: 175-274/515.0
CVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYL
   .   || .. ||  |. |. .||  .. . .      | | |.    || | ||.| .. .. ..   . ||||. |. .| .||.|.  ...| ..
tqfhfteWP.dkGvpkhtssllklikevkadhgqy.....thpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafi

YDVMLH
|...| 
ygavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 692-803 1.4e-13 45.6 In-house 181-293 (325) alignment 
Range on Protein: 692-803
Range on HMM: 181-293/325.0
CVIQVRMWP--IENKVPlstTGLIDVIKMARSWRKRAPD-RPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEY
   |.. |.    .| |   . || ....     .|       . | .|   .|| | ||.|     ....  . .||.|  || .| .||....  |.|
kqfqlqswddmGvqkrp...atlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqy

KYLYDVMLHWYMT-NP
  .|. .   ||. | 
iliyealveaymsgnt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 692-817 1.9e-12 42.2 In-house 188-315 (319) alignment 
Range on Protein: 692-817
Range on HMM: 188-315/319.0
CVIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRAPDRpetKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYL
     . || .  || ... |. ..|  |  ...  .|   .. .|    || | ||||  .. .|.|. .. |||.. |. .| .|..|..   .||..
tqfhflGwp.dvGvpdypsdlmrlvkkvrhltskenhr...anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfi

YDVMLH------WYMTNPDYRIYDKEDSEDTD
|  .|         .. ||.  | .| |...|
ysalleehlfghsdvampdfpayleelsnksd
0048076 (Phosphotyrosine protein) phosphatases II 692-797 2.8e-08 29.1 In-house 46-141 (145) alignment 
Range on Protein: 692-797
Range on HMM: 46-141/145.0
CVIQVRMWPIE-NKVPLSTTGLIDVIKMARSWRKRapdrpeTKPTIVMSHNGVSRVGVYIGANICIDqmdidHEVDVFHAVKMMRINRPQLIDMKDEYKY
 .||.  .|.. . || ..  |...... ....|.       .|..|  . ||.| |....| ...      . |....|....|  ||. .   . ...
lgiqylylpwpDhgvpdllellleflefieealke......ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

LYDVMLH
||.. |.
lyefele
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 693-805 1.8e-15 51.8 In-house 141-248 (250) alignment 
Range on Protein: 693-805
Range on HMM: 141-248/250.0
VIQVRMWPiENKVPLSTTGLIDVIKMARSWRKRApdrpETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLY
 ..   || .  ||  .|  ....|  .. ...|    ...| ||   .||.| | .|  .  .... ... ||||. .|..|..||. .. .. | ..|
qlhfvvWP.dkgvPevatavLellkkvqasqqqa....gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvy

DVMLHWYMTNPDY
 ..|.   .  ||
eiilkaldsvedy
subfamily_PTPRB_pd Subfamily PTPRB 693-799 6e-14 46.8 In-house 183-285 (293) alignment 
Range on Protein: 693-799
Range on HMM: 183-285/293.0
VIQVRMWPiENKVPLSTTGLIDVIKMARSWRKrapDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLY
  .   || .  || .|. |.| ... |.. .   .  ...|..|    || | |..|  .  ..... .  ||.|  |  .| .| .|.  ...| ...
qyhftsWp.dhgvPektktlldfvrtvreaie...ktaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifih

DVMLHWY
...|.  
qcvldll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 693-798 9.4e-11 36.2 In-house 177-277 (287) alignment 
Range on Protein: 693-798
Range on HMM: 177-277/287.0
VIQVRMWPIENKVPLSTTGLIDVIKMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLY
  |.  |. . ||.   | |. . .| .. |||.       . .|   ..| | .... |.. |.. . .  .|||  .| .|| .|. .   ..||...
qyqitnWdstgkvtepqtillvieemyktqrkrg.....ntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfin

DVMLHW
|..|. 
divley
PTPc_DSPc_SM00012 695-796 1.8e-17 58.9 In-house 6-104 (105) alignment 
Range on Protein: 695-796
Range on HMM: 6-104/105.0
QVRMWPIEnKVPLSTTGLIDVIKMARSWRKRAPDrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDID-HEVDVFHAVKMMRINRPQLIDMKDEYKYLYD
..  || . .|| ... ......  ..... . .   .||..|....||.| |... . |...|..   .|||.|  ||..|  ||........| .||.
hytgwpdh.gvPeesdsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VML
..|
all
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 695-797 7.7e-17 56.3 In-house 181-277 (288) alignment 
Range on Protein: 695-797
Range on HMM: 181-277/288.0
QVRMWPIENkVPLSTTGLIDVIKMARSWRKRApdrpeTKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDV
|  .|| .. || |.. |......     .       |.| ||   .|| | |..| ..  ||... .  .||. .|. .| .|..|.. .  | ..|.|
qylaWpdhg.vPeskapllellrqvkvanqad.....tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyev

MLH
.|.
lls
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 695-797 3.8e-08 27.2 In-house 180-277 (439) alignment 
Range on Protein: 695-797
Range on HMM: 180-277/439.0
QVRMWPiENKVPLSTTGLIDVIKMARSwrkrAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDV
.   || ...||  .. ..| ..   |    | |. |. | .|    || | |  |  .|...|. .. .||.   ||..| .| |...   .| ..|. 
hyiawp.dknvpaqashvldflrains....andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiyna

MLH
.| 
vle
subfamily_PTPRN_pd Subfamily PTPRN 696-793 3.9e-07 24.1 In-house 194-286 (297) alignment 
Range on Protein: 696-793
Range on HMM: 194-286/297.0
VRMWPiENKVPLSTTGLIDVI-KMARSWRKRApdrpetKPTIVMSHNGVSRVGVYIGANICIDQMDI-DHEVDVFHAVKMMRINRPQLIDMKDEYKYLYD
   || |. || |.  |..   |. .|.| |.       | .| . .|. | ||||  .. ....    .|.|.  ... .| .||.|.  ||.... . 
flswp.eegvPasaksllefrrkvnksyrGrs......cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 707-798 1.2e-11 39.1 In-house 175-263 (270) alignment 
Range on Protein: 707-798
Range on HMM: 175-263/270.0
LSTTGLIDVIKMARSWRKrapDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHW
|||. |. ...  | ..|   .  ...|..|   .|| | |. |  .|..  .. ...||| . .. .| .|..|..  ..|..|| .....
lstdqllkmlravrrsek...eldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 708-807 6.2e-15 50.1 In-house 197-291 (297) alignment 
Range on Protein: 708-807
Range on HMM: 197-291/297.0
STTGLIDVIKMArswRKRAPDRPETkPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMTNpDYRI
|.. |...|.     ||   .. |. | .|   .|| | ||..  . .. ..  ..|||.|  ||..| .||.|.  |..||..| ..|   ... |.||
sassllklisev...rkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse.dtri
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 713-798 2.2e-08 27.9 In-house 351-437 (440) alignment 
Range on Protein: 713-798
Range on HMM: 351-437/440.0
IDVIKMARSWRKRAPDRPETKP-TIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHW
.| ..     |     ||   |  .|    |.   ||.     |..|.. |  .|||  ....|. ||...    .|   | .. | 
mdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykllthh
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 715-801 9.1e-12 39.0 In-house 302-387 (392) alignment 
Range on Protein: 715-801
Range on HMM: 302-387/392.0
VIKMARSWRKRAPDRPETkPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHWYMT
..|. |. .  . .. |    .|    |  | ||.  |  || |.   . ||.| .||..| .| | .. ..|| ..|||.  .  |
llkliravkgstnskkef.silvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyafvydvireylht
subfamily_CG42327_pd Subfamily CG42327 724-797 1.2e-08 29.0 In-house 239-313 (319) alignment 
Range on Protein: 724-797
Range on HMM: 239-313/319.0
KRAPDRPETKPTIVMSHNGVSRVGVYIGANICIDQMDID-HEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLH
 |.  | .  | .|   .|| | |. | ..| | ...   . ||. . |  .| .| . .  |. |...| |.  
srsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 732-798 9.3e-08 26.4 In-house 192-258 (267) alignment 
Range on Protein: 732-798
Range on HMM: 192-258/267.0
TKPTIVMSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVMLHW
 .| .|   .|| | | .. ..  ....  .  .|.|. .. .|  |. |.| |..| |..... ..
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 738-795 8.3e-06 20.1 In-house 3-60 (69) alignment 
Range on Protein: 738-795
Range on HMM: 3-60/69.0
MSHNGVSRVGVYIGANICIDQMDIDHEVDVFHAVKMMRINRPQLIDMKDEYKYLYDVM
    |  | | .|   . . ..  .  ||.|  |. ||  || ..  ..|| ...| .
hcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal