Gene T22C1.8 in Caenorhabditis elegans

Synonym: CELE_T22C1.8, T22C1.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf9
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP186_AA protein Get Run
CeleP186_AA_111-384 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 106-385 2.2e-170 559.8 In-house 8-290 (290) alignment 
Range on Protein: 106-385
Range on HMM: 8-290/290.0
DVQKKVFFKFASDAVKKNPPEYSVEFMTKVKPY-PGQPMERKIFDANP--TKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGLNAPFILTQGATAATV
 || ..|.|||||.||||..|...|...|.||| |.|..||||||.|.  .|||||||||||.|||||.||.||||.|||||.||.|.|||||||...||
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtv

IDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLR
||.||||...|.|.||||||..|||||||.||||||.||..|||..|.|||.||||||||||.|||||..|.||||.||||..|||||..|..||.||||
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallr

MLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWD
.|.|.|.|||||.|||||||||||||||||..||||.||||||||...|||||||..|.||||||.|||.||...|||..|..
tlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyie
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 107-386 2e-54 179.4 In-house 4-295 (305) alignment 
Range on Protein: 107-386
Range on HMM: 4-295/305.0
VQKKVFFKFASDAVKKNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGLNAP--FILTQGATAATVID
 |||   ||   ...| |     ||..  .    . |.      .  ||||||| | |  || |      .|||||||     |  || ||     |  |
qqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcad

FWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAW----------TILCSLEDDKDANIIKRTLSVRNVdNGKEHILKHLHTKSWPDRCVP
|| | .  |  .| |||...| |  ||..|.. | .. ..|             .   ....| .|.. .  | .     .| .  .| |   |||| ||
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvp

NSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLG-TCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWDD
 . .|.| .|   |.. ||..|||||||||||. | .|  |. |  |. ..      . .|. |  ||| | ||. . |...|| ....  |.
aadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkllde
subfamily_PTPRB_pd Subfamily PTPRB 110-377 2.7e-59 195.6 In-house 10-284 (293) alignment 
Range on Protein: 110-377
Range on HMM: 10-284/293.0
KVFFKFASDAVKKNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNAP--FILTQGATAATVID
. | .. ..  ...  ..| |. .  .    | ..     .| .||||....  | .|| |   .|  . ||| |||..|.|.|  || |||    || |
ekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvdd

FWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgEAMTFGAWTILCSLEDDKDaNIIKRTLSVRNvdNGKEHILKHLHTKSWPDRCVPNSTMALLRML
|||||  .|.  |||| ...| || || .|.|..  |....|  ..    |.... . . |.|....  . .|. ....| .||||  ||..| .||...
fWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeele.dwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

YIVRTAS------GPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
. ||.|       .|..||||||.||||||.|..  || ...   .|..|.  .||..|.  .|   ||. . | ....
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 110-383 1.6e-23 77.8 In-house 7-284 (303) alignment 
Range on Protein: 110-383
Range on HMM: 7-284/303.0
KVFFKFASDAVKKNpPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDggdGDYIHANYVNgLN--APFILTQGATAATVIDFWR
. .   | . ....  . .|. . ||  |    . .. |  |  |||. ||.| | ..| |||     ||||.|.. |.     ||||   . |  |||.
qkwkllakrtlded.aniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd...ssyihasyle.ldsskkailtqlplshtaadfwq

MVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKaGEAMTFGAWTILcsLEDDKDANIIK-RTLSVRNVDNGKEHILKHLH-TKSWPDRCVPNS-TMALLRML
|... |   ...|    |  |      .|..  . . |   .|   . . |  .. .  .| |  | ||. . . |.|  |.||   .|.  .  ... .
miieqkvkcvlllltdseydklggdsvfprn.qdflkfeersir..vgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqi

YI----VR--TASGPVTVHCSAGIGRTGTFVAIEA-CLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGY
.     .|  . | |      .| ||.|||  .|.  | . ..   |||.     .|| |  ..|   |.  .  .| ..  |||.
wqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
0051299 (Phosphotyrosine protein) phosphatases II 112-377 4e-76 251.5 In-house 10-285 (288) alignment 
Range on Protein: 112-377
Range on HMM: 10-285/288.0
FFKFASDAVKKNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNG--LNAPFILTQGATAATVIDFW
..|.    .....  .  || . .. .|  ..   .. .| .||||.|....| .||.||. ..   .|||.|.|..|  |.  ||.||| .  || |||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

RMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNV----DNGKEHILKHLHTKSWPDRCVPNSTMALLR
||| . .. .||||....|.|. |||||.|.  |. .|.| .|. .  |.  ......||| |.|.     .|.... .|.| ..||| .||.|. .||.
rmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

MLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
.| .||.|    .||| ||||||.||||||.|.. .|. |  ....|.|.. . ||. | |..|   ||. . ..|. |
flrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0043336 (Phosphotyrosine protein) phosphatases II 112-377 6.8e-70 231.0 In-house 7-276 (278) alignment 
Range on Protein: 112-377
Range on HMM: 7-276/278.0
FFKFASDAVKKNPPEYSVEFMTKVKPYPgQPMERKIFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGL--NAPFILTQGATAATVIDFW
. |.  . .....  .. || .  .  .  ...  .. .| .||||||....| .||.||. |   | |||.|.||.|   .  ||.||| .  || |||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RMVVHTKTAYIVMLCEVMEDGKAKCAQYYPekaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYI
||| . ..  ||||.| .|.|. |||||.|   |. .|.| .|. .  |.  ..... ||| | |  .|....  |.| ..||| .|| |.  ||..| .
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

VRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||.     .||| ||||||.||||||.|.. .|. | .....||. . . ||. |.|..| . ||. | ..|. |
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 112-377 1.6e-44 147.0 In-house 7-277 (287) alignment 
Range on Protein: 112-377
Range on HMM: 7-277/287.0
FFKFASDAVKKNPPEYSVEFMTKVK-PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSdGGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRM
| .|. .  .|.  ...  |..  .     . .  .|   |  |||.....  |  ||.|  | . ||| | ...| .    ||....  . |. .||..
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfWkl

VVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGeaMTFGAWTILCSLEDdKDANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRC-VPNSTMALLRMLYI
. . .   |||||. .|. . .| ||.||..   ...| ..|    |. . |. |.|.| |.| . .|... .|  .  .|...  |..    || .   
iddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

VRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
..|    . ... ||||...||...|.|..  ..       .|..   .  |  . ||.|   ||. ...|...|
yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
0040438 (Phosphotyrosine protein) phosphatases II 113-385 1.6e-77 256.2 In-house 6-283 (317) alignment 
Range on Protein: 113-385
Range on HMM: 6-283/317.0
FKFASDAVKKNPPEYSVEFMTKVKPYPGqPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNGL--NAPFILTQGATAATVIDFWR
 ..  | .|..    . ||..  .  .  ...  .. .|. ||||.|....| .||.||. |     |||.|.||.|   .  ||.||| .  || ||||
llalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV
|| . .. .||||.| .|.|. |||||.|.  || .|.| .|. .  |.  .|.|. ||| | . .........|.| ..||| .|| |.  ||..| .|
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

RTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWD
|.|    .||| ||||||.||||||.|.. .|. |  ....|.  . . ||. |.|..|   ||. | ..|..| | .... 
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
subfamily_PTPN13_pd Subfamily PTPN13 119-375 9.6e-52 170.9 In-house 7-266 (273) alignment 
Range on Protein: 119-375
Range on HMM: 7-266/273.0
AVKKNPPEYSVEFMTKVKPYPGQPMERKifDANPTKNRYKDVVCNDITRVILSDGGDgdYIHANYVNGL----NAPFILTQGATAATVIDFWRMVVHTKT
..... |.   . . ..||     . .|  ..| .||||..|.  | |||.|.| |   || |....      .  .|..||    || |||.||   |.
kldqqqPaeefkelrelkpldtcevgkk..kenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqka

AYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVR---TAS
  |.|.    |.|| || .|.||.... ..      .  |.  |  .   |.| |.... |. . . ||.  .|||  ||.|.. ||...  ||   | .
eviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
||. |||||||||.||...|.. |...   ||.|.  . | ||. | | .| . ||.   ....
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 119-231 3e-06 20.9 In-house 5-118 (332) alignment 
Range on Protein: 119-231
Range on HMM: 5-118/332.0
AVKKNPPEYSVEFMTKVKPYPGQpmeRKIFDANPTKNRYKDVVCNDITRVILS-DGGDGDYIHANYVNGLN--APFILTQGAT-AATVIDFWRMVVHTKT
||  . ||   .. |    ||        |  |   ||   . | | .|| |. . |  |.  |..|.| .  . .|..|      |   |||||   | 
avtvegpellnqmhtsamtypnt...ydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkp

AYIVMLCEVMEDGKAKC
. |... .. |  | |.
smilvfgdidekqkrka
0050432 (Phosphotyrosine protein) phosphatases II 122-380 3.6e-81 268.2 In-house 39-301 (308) alignment 
Range on Protein: 122-380
Range on HMM: 39-301/308.0
KNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILsdGGDGDYIHANYVNGL----NAPFILTQGATAATVIDFWRMVVHTKTAYI
...  .. ||..  . .|  ...   . .| .||||||....| .||.|  ... |||.|.||.|     .  ||.||| .  || |||||| . .. .|
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

VMLCEVMEDGKAKCAQYYPEKAG-EAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA--SGPV
|||.. .|.|. |||||.|.. | . ...| .|. .  |.  ......||| ..|...|......|.| ..||| .||.|. .||..| .||.   .||.
vmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpi

TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
 ||||||.||||||.|.. .|. |  ....|.... . ||  |.|..|   ||. | ..|. | |.
vVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0045450 (Phosphotyrosine protein) phosphatases II 122-379 1.1e-71 237.4 In-house 26-305 (307) alignment 
Range on Protein: 122-379
Range on HMM: 26-305/307.0
KNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDG----GDGDYIHANYV--------NG--LNAPFILTQGATAATVIDFWR
..  .   | . .|....  ...   . .| .||||||....| |||.||.     .|.|||.|.||        .|  |.  ||.||| .  || ||||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

MVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNV-DNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYI
|. . .. .||||.| .|.|. |||||.|.. || .|.| .|. .  |.  ..... ||| | .   .|......|.| ..||| .|| |.  ||... .
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VRT------ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKE---LDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
||.       .||| ||||||.||||||.|.  .|. | ....   .||| . . ||. | |..|   ||. | ..|. . .
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 126-376 1.6e-40 134.4 In-house 35-289 (319) alignment 
Range on Protein: 126-376
Range on HMM: 35-289/319.0
EYSVEFMTKVK-PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILS--DGGD-GDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVM
.. |||    | . ..  ..    | |  |||. ...  | ..| |   .| .  ||| | .|.|   .  .| .||    |. |||||.   ... ||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LCevmedgKAKCAQYYPEKAGEAMTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGKEHIlKHLHTKSWPDRCVPNSTMALLRMLYIVR------TASGP
|       | ||.||.| |. .    .   .  |.|. ..  . .  ||     ... .| .  | . |||  ||.... |.|..  ||          .
lt......kdkcsqywplkivikeerfkvkv.dsveetaeyvvrdielsedgkekdirki.tqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

VTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
. ||||||.||||....... |. . . | .|.  . | ||. |   .|  .||. .   |..
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0047943 (Phosphotyrosine protein) phosphatases II 127-377 1.7e-75 249.3 In-house 14-271 (273) alignment 
Range on Protein: 127-377
Range on HMM: 14-271/273.0
YSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILsDGGDGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVM
.  || . .. .|  ...  .. .| .||||||....| .||.| ..|. |||.|.||.|  |.  ||.||| .  || |||||| . .. .||||.|..
lleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelv

EDGKAKCAQYYPEKAGE-AMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPVTVH
|.|. |||||.|.. ||  .|.| .|. .  |.  ......||| ..|...|.... .|.| ..||| .|| |.  ||... .||.       .||| ||
elgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVH

CSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||||.||||||.|.. .|. |  ....|.| . . ||. | |..|   ||. | ..|..|
CsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 128-379 5.9e-70 231.4 In-house 35-290 (297) alignment 
Range on Protein: 128-379
Range on HMM: 35-290/297.0
SVEFMTKVKPYPgqPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD----GDYIHANYVNGLNA---PFILTQGATAATVIDFWRMVVHTKTAYIVML
  ||.. ..  |  ...   . .| .||||||....| .||.|.. ..     |||.|.||.| .     ||.||| .  || |||||| . .. .||||
llefeellslkp..dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmL

CEVMEDGKaKCAQYYPEKAGeamTFGAWTILCSLEDDkDANIIKRTLSVRNvdNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPV
.. .|.|. |||||.||. |   |.| .|. .  ..  ..... |||.|.|  ||......|..  .||| .||.|.  ||..| .||.       .|||
tklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
 ||||||.||||||.|.  .|. |  ....|.| . . ||. | |..| . ||. | ..|. . |
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045098 (Phosphotyrosine protein) phosphatases II 128-379 6.4e-67 221.2 In-house 10-273 (278) alignment 
Range on Protein: 128-379
Range on HMM: 10-273/278.0
SVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVIlsdggdgDYIHANYVNGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDG
. ||  .. ... . ..  ..  |  ||||||....| .||.       |||.|.|..| .  ||.||| .  || |||||. . .. .||||.|..|.|
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KAKCAQYYPEkaGEAMTFGAWTILCSLEDDKdANIIKRTLSVRNV----DNGKEHILKHLHTKSWPDRCVPNST--MALLRMLYIVRT------------
. |||||.||  |. .|.| .|. .  |.    ....||| |.|.     ..... ..||| ..||| .||...  . .|..|  .|             
rekcaqywpe..ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----ASGPVTVHCSAGIGRTGTFVAIEACLQILtdGKELDLLGTCRALRNSRAG-SIQVDIQYMALVQILINYGK
      .||| ||||||.|||||.||.  .|. |  .. .||| . . ||. | | ..|   ||. | . |. . .
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0036941 (Phosphotyrosine protein) phosphatases II 129-383 8.6e-79 260.2 In-house 17-282 (297) alignment 
Range on Protein: 129-383
Range on HMM: 17-282/297.0
VEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILsDGGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMED
 ||.. .. ..  ...  .. .| .||||||....| |||.| |... |||.|.||.| .    ||.||| .  || |||||| . ..  ||||.|..|.
kefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

GKAKCAQYYPEKAGEAMTFGAWTILCSLEDDK-DANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPVTVHCS
|. |||||.|.. || .|.| .|. .  .. . ..... ||| | ...||......|.| ..||| .||.|.  ||...  ||.       .||| ||||
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGIGRTGTFVAIEACLQILT---DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGY
||.||.|||.|.. .|| |      ...|.| . . ||. |.|..|   ||. | ..|... | . .
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_PTPRD_pd Subfamily PTPRD 130-377 1.9e-64 213.3 In-house 28-280 (564) alignment 
Range on Protein: 130-377
Range on HMM: 28-280/564.0
EFMtKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVM
|.  |... .  ..|    .||  ||||...|  | .||.||      . ||| |....| ...  .| ||| .| |. ||||||   ... |||| .. 
eyk.kieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkle

EDGKAKCAQYYPEKaGeAMTFGAWTILCSlEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----ASGPVTVHCSA
| || ||..|.||| |   |.|  |.  . |  . |... ||..... .. . .  .. |  ||||..||.|. .||...  ||.     .||..|||||
EkgkvkchkYWPek.g.tetygeltVtle.eeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa

GIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
|.||||||..|.|.|. ... | .|. .. .|||. |   .|   ||. . ... ..
GVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
0046845 (Phosphotyrosine protein) phosphatases II 132-380 1e-76 253.3 In-house 7-276 (284) alignment 
Range on Protein: 132-380
Range on HMM: 7-276/284.0
MTKVKPYP--GQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD----GDYIHANYVNGL-------NAPFILTQGATAATVIDFWRMVVHTKTAYIV
.. .. ..    ...  .. .| .||||||....| .||.|.  ..    .|||.|.||.|        .  ||.||| .  || |||||| . .. .||
eellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIV

MLCEVMEDGKAKCAQYYPEKaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA------S
||.| .|.|. |||||.|.. || .|.| .|. .  |.  . ....|||...|.. .|......|.| .||||..|| |.  ||..| .||..      .
mltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

GPVTVHCSAGIGRTGTFVAIEACLQILTDGK---ELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
||. ||||||.||||||.|.. .|. |  ..   ..|.|.. . ||. | |..|   ||. . ..|..| | 
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 132-372 5.8e-40 131.9 In-house 15-260 (283) alignment 
Range on Protein: 132-372
Range on HMM: 15-260/283.0
MTKVKpYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVN-----GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMED
. ..   | .. . .  | |..|||....|  |  || |      ||| | ..        .  .| .|.    ||.|||.|| . | . |||| ...||
lkrls.vpdldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

GKAKCAQYYPEKAgeAMTFGAWTILCSLEDDKDAnIIKRTLSVRNVDNGKEHI-LKHLHTKSWpDRCVPNSTMALLRMLYIV-----RTASGPVTVHCSA
 . ||.||.|..   .. .| .|.    |  ...  |.. | .|.    |. . | |     |   . ... .  |  .  |     .   ||. ||||.
lrikCsqyWPkrG..sedyGeftvtlrkettsns.fiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCst

GIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
|||||..|.|. | .. .     .|.  . . .|. | . .|   ||. . .
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 133-382 6.7e-48 158.1 In-house 17-274 (285) alignment 
Range on Protein: 133-382
Range on HMM: 17-274/285.0
TKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDgGDGDYIHANYVN--GL-NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKA
 |.| |         ..|||  ||| || | . |||.| .  | |||||...   |  .. .| |||    |. |||.|. . | ||..||| ..| |  
dkikgymppnctytayeanpdlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggve

KCAQYYPEKAGEAMTFGAWTI-LCSLEDDKDANIIKRTLSVRNVDNGKEH--ILKHLHTKSWPDRCVPNSTMALLRMLYI---VRTASGPVTVHCSAGIG
||| ||||| || . || . | |   ...  |  |  .|.| | ..       ..|..   |||.  |. .  .. .      |     |. ||||||.|
kcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvg

RTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNG
|| ||| |. .   . .  ....|   | .|  |  ..|  .|.. |  .|..|   .|
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg
DSPc_SM00195 137-377 1.4e-75 249.4 In-house 12-261 (263) alignment 
Range on Protein: 137-377
Range on HMM: 12-261/263.0
PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKC
 .. .... .....| .|||||.....| |||.|..     . |||.|||..|   .  .|.||| .  || ||||||...|. .||||.| .|.|| ||
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

AQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGT
..|.||..|. .|||  .. .  .. |...||.|||.... .. ... ..... |.|||. ||.||. .|..|  |..     |||. ||||||.|||||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgt

FVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||.|. .|. |...|..|.  ....||..|.|..| . ||.........|
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 137-377 1.4e-75 249.4 In-house 12-261 (263) alignment 
Range on Protein: 137-377
Range on HMM: 12-261/263.0
PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKC
 .. .... .....| .|||||.....| |||.|..     . |||.|||..|   .  .|.||| .  || ||||||...|. .||||.| .|.|| ||
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

AQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGT
..|.||..|. .|||  .. .  .. |...||.|||.... .. ... ..... |.|||. ||.||. .|..|  |..     |||. ||||||.|||||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgt

FVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||.|. .|. |...|..|.  ....||..|.|..| . ||.........|
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 137-376 1.1e-39 131.6 In-house 11-253 (284) alignment 
Range on Protein: 137-376
Range on HMM: 11-253/284.0
PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILS--DGGD-GDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCevmedgKAKC
. .|  ..    | |  |||. ...  | ..| |   .| .  ||| | ...|   .  .| |||    |. |||||.   ... ||.|       | ||
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

AQYYPEKAGEAMTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGKEHIlKHLHTKSWPDRCVPNSTMALLRMLYIVR------TASGPVTVHCSAGIGRT
.||.| |. .    .   .  |.|. ..  . .  ||     ... .| .  | . |||  ||.... |.|..  ||          .. ||||||.|||
sqywplkivikeerfkvkv.dsveeseeyvvrdielsedgkekdirki.rqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
|....... |. . . | .|.  . | ||. |   .|  .||. .   |..
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN3_pd Subfamily PTPN3 139-374 2.7e-58 192.1 In-house 29-271 (280) alignment 
Range on Protein: 139-374
Range on HMM: 29-271/280.0
PGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVN------GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCA
||  ..     .| .||||.|..  |.|||.|...   ||| |||||      ||   .| |||  | |. |||.|| . |.  |||| ...|.|. || 
pglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYYPEkAGEAMTFGAWTILCSLEdDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTF
||.||  .. ...| ... |. | |.. ... | | ... .. .|. . .|   .||| .||...  .|...  ||..    . || ||||||||||| .
qyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

VAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
...| .|...   ...  |   | .|. ||  .|   ||  . . .
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 139-187 1.3e-06 22.5 In-house 36-84 (95) alignment 
Range on Protein: 139-187
Range on HMM: 36-84/95.0
PGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGL
 | |      .||  |||. ...  | |||.|.   | ||| | .|.| 
sgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 140-377 8e-54 177.7 In-house 30-276 (307) alignment 
Range on Protein: 140-377
Range on HMM: 30-276/307.0
GQPMERKIFDANPTKNRYKDVVCNDITRVILS-DGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYP
 . .  . |.||. ||||.|| | | .|...  ||   |||||||.     |  || .||   .|. .|| |..  |   ..|||.|.| .| || ||.|
pegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywp

EKAGEAMTFGAWTILCSLED------DKDANIIKRTlSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVA
 . |. ..||  .   |...        | ..|. | ... .  .|   ..||  . |||| ||.  .. . .|  ||    || ||||||.||.|| ||
leegqklvfgeapntisvanlgakklapdedlinvt.tlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtiva

IEACLQILTDGKE-LDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
|    . . .|..  |.    . ||. |  .|| ..||. | ..|..|
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 140-377 1.5e-53 176.9 In-house 35-282 (305) alignment 
Range on Protein: 140-377
Range on HMM: 35-282/305.0
GQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQY
..... .  .|| .|||.|...  |  |.||.   .    ||| |.||.| .    .|..||    || ||||..|..|.  ||||....|.|| || ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

YPEKAGEAMTFGAWTILCSLEdDKDANIIKRTLSVRNV-DNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA---S-G-PVTVHCSAGIGRTGTF
.||. .| . ||  ..  . |  . .. |.| |.. .  .. ... . ...  .|||  ||... .||...  |. .   . | |..||||||.||||.|
Wpesktekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

VAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
.|..  |. |   ...|. .  ..||..| . .|   ||. | ..| ..
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 141-376 1.5e-51 170.1 In-house 31-274 (281) alignment 
Range on Protein: 141-376
Range on HMM: 31-274/281.0
QPMERKIFDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYY
.. .    |.| .||||...|  | ||| .   ..  . ||| ||.|.|.  .. .| |||   |.. .||.||. .|   |||. . .| || || .|.
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PEKAgEAMTFGAWTILcSLEDDKDANIIKRTLSVrNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVA
|... .....|  |.  |..  . |. |.|.... . ..|..  ...|. ..|||  ||..|..||     |.         |. .|||||.|||||..|
Pddn.selkygdvtvk.staeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyia

IEACLQIL-TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
..  .. . .. .|||.  . . ||..|   .|  .||  . .....
lDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 142-380 1.4e-51 170.2 In-house 20-270 (274) alignment 
Range on Protein: 142-380
Range on HMM: 20-270/274.0
PMERKIFDaNPTKNRYKDVVCNDITRVIL----SDGGDGDYIHANYVNGLN---APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQY
. | ..|  . ||||||... |. .||.|    |.  | .|| |||. | .     .. |||  . || |||||. ....  |||| .. |  ..|||.|
qeeldvfg.sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

YPEKAGE--AMTFGAWTILCSLEDDKDANIIkRTLSVRNVDNGKEhiLKHLHTKSWPDRCVPNSTMALLRMLYIVRTA-------SGPVTVHCSAGIGRT
.|.. .   . ..|   |  .   ...   . |.|..... . ..  .||    .|||. .|... .||...  |...        .|| ||||||||||
fPdaedyeiserygdveikvekiverndysv.rklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
| |.||. ... | . . .|.|..   ||  | | .| . ||  . ..|. | | 
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 142-378 2.3e-46 153.0 In-house 37-283 (290) alignment 
Range on Protein: 142-378
Range on HMM: 37-283/290.0
PMERKIFDANPTKNRYKDVVCNDITRVILS-DGGDGD----YIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQY
 .....   | ..||....| .|  |..|   .|. |    ||.| |..|   .  .|.||| .  |..|||..... |.. ||||....|.|| || ||
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

YPEKaGEAMtFGAWTILCSLEDDKDaNIIKRTLSVRNVDN-GKEHILKHLHTKSWPDRC-VPNSTMALLRMLYIVR----TASGPVTVHCSAGIGRTGTF
.|.. . .. .| ..|  . |   . ..|.|.|.|.| .. |......... ..|..   |.| .  || .  ...    .  ... ||||...||...|
Wpds.dtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavf

VAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
.|..  ..        |..   . .|  . ||.|   ||  ..||...| 
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_egg_pd Subfamily egg 142-380 1.2e-32 107.9 In-house 31-272 (307) alignment 
Range on Protein: 142-380
Range on HMM: 31-272/307.0
PMERKIFDANPTKNRYKDVVCNDITRVILS--DGG-DGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDgkAKCAQYYP
.... . | | .| | | | |.| .|| |    |   .|.||||.|.|  |   |||.|     || ||||||   .  |||||    |    .|  |.|
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

EKAGEAMTF--GAWTILCSLEDDKdANIIKRTLSVRNVDNGKEHilKHLHTKSWPDRCVpNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEAC
    ... .  |.  | .   |.| |. . |   .. |   .|   ..|    .  . . .     ||.|  .| .| || |..  |. ...|.||||  
kaesdslvtvpGslrienlkvdsk.adplfrvtklklvGgddee..rflehwqgdvnns.sdvysplrvlrklrnlskpvvvqdilGvskaatlvaieia

LQILTDGK--ELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
|  |  |      .| ..  ||  |  |..  ..|. . .... . .|
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
0040439 (Phosphotyrosine protein) phosphatases II 143-379 1.2e-64 213.7 In-house 3-247 (249) alignment 
Range on Protein: 143-379
Range on HMM: 3-247/249.0
MERKIFDANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPE
..  .. .|. ||||.|....| .||.||.   . ..|||.|.|..|   .  ||.||| .  || |||||. . .  .||||.. .| |. |||||.|.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

kaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPVTVHCSAGIGRTGTFVAI
  |. ...| .|. .  ..   .... ||| . |. .|...  .|..  .|||  || |.  ||... .||.       .||| ||||||.||||||.|.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

EACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
  .|. |   ...||. . . ||. | |..| . ||. | ..|. . .
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 143-377 4.6e-32 105.9 In-house 32-292 (301) alignment 
Range on Protein: 143-377
Range on HMM: 32-292/301.0
MERKIFDANPTKNRYKDVVCNDITRVILSDGG-----DGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYY
.. .. ..| . ||.|...  |  |.||.          .|| |.|..| .    || .||    |..||||.... |.. |||...  |. |.|| ||.
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

PEKAGEAMTFGAWTILCSLEDDkDANIIKRTLSV-----------------RNVDngKEHILKHLHTKSWPDRCVPNSTMALLRML--YIVRT---ASGP
|.   |  .||  |.. . |     . . | |.|                 ..    . . .  |.  .||.  |       |. .   | |.     ||
pnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggp

VTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
| ||||....|.|......  |         |. .  .|.| |. | ..   ||. . ...  |
vvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 145-226 3.3e-09 30.7 In-house 31-122 (347) alignment 
Range on Protein: 145-226
Range on HMM: 31-122/347.0
RKIFDANPTKNRYKDVVCNDITRVILSDG----GD----GDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMED
 . .. . .||| |||  .| |||.||      .       || | ...  ||   .||||     || |||.||  || . .| . | ..|
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
0037934 (Phosphotyrosine protein) phosphatases II 146-376 9.5e-60 197.5 In-house 5-240 (243) alignment 
Range on Protein: 146-376
Range on HMM: 5-240/243.0
KIFDANPTKNRYKDVVCNDITRVILsDGgdGDYIHANYVNGLNApFILTQGATAATVID----FWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPekaGE
 .. .| .||||.|....| .||.| .|  .|||.||......  .|.||| .  || |    ||||. . .. .||||.| .| |. |||||.|   ||
allpenlsknrysdilpydhsrvkl.eg..sdyinanliyvtpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

AmTFGAWTILCSLEDDKdANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVR------------TASGPVTVHCSAGIGRTGTF
  |.| .|. .  |  . .... |||...|.| .. ..   |.|  .||| .||.|.  ||..| .||              .||| ||||||.|||||.
v.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

VAIEACLQILtdgkELDLLGTCRALRNSRAG-SIQVDIQYMALVQILIN
.|.  .|. |    ..||. . . ||. | | ..|   ||. | ..|. 
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 146-378 4.9e-58 191.5 In-house 37-290 (297) alignment 
Range on Protein: 146-378
Range on HMM: 37-290/297.0
KIFDANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAG
    || .||||.||.| | ||| |.        |||.||.|.| .    || |||.   || ||||||   ..  |||   |.| |. ||.||.|.. .
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

EAMTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS-----------------GPVTVHCSAGIG
... ||  ..  ..|...  .  .|.| ..||.....  . |    ||||  ||.|...|| .|  || .                   |. ||||||||
ssaefgdlsv.snveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
|||||.... ||. | .   .|.  | . ||. || |||.. ||.   . ...| 
rtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 146-376 5.3e-51 168.4 In-house 38-269 (288) alignment 
Range on Protein: 146-376
Range on HMM: 38-269/288.0
KIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
. | ||||..||... . ||||| |||  |  ||.|| |   .    .| .|    .|.  .|.|....   |||||||..| || | |.|.| | ||..
dsfianptrdryenlprcditrvklsddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

TFGAWtilCSLEDDKDANiIKRTLSV---RNVDNGKEHI-LKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT
 .|     |.   .| |. |.....|   |.  .|.|.. .|.|| . |.| .||.. .. ||.| ....   |. ||.|||.|||||.. |   |. | 
rigrl...ctvvkkkrad.idklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslr

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
    | .   .  ||..|  .||.  ||. . ... .
lddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 146-378 3.9e-28 93.2 In-house 28-259 (267) alignment 
Range on Protein: 146-378
Range on HMM: 28-259/267.0
KIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDgkaKCAQYYPEKAGEAM
 |   |  .||. |..  | |||||..  . .|| | ||.| .    ||.||..   |. ||. .. . | . ||.|  | .|   .  ...| | |.| 
siaeknqernrlddnlpyddtrvilrtkee.eyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqak

TFGAWTILCSLEDD-KDANIIKRTLSVRNvdnGKEHILKHLHTKSWPDRCVPNSTM-ALLRMLY--IVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT
 .   |.  ||| . .| .||   | ..|      | .   . | |      .  .  |. .|    .  .. |. |.||.|.||.|||. |.. |. . 
kyqdltvehslekeendyqiitlelkfkn...esahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
    .|.    | .|. | | ...  .|. . ..| .| 
tegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 146-381 3.2e-21 70.0 In-house 46-288 (302) alignment 
Range on Protein: 146-381
Range on HMM: 46-288/302.0
KIFDANPTKNRYKDVVCNDITRVILSDGgDGDYIHANYVN--GLNAPFILTQGATAATV---IDFWRMVVHTKTAYIVMLCEVMEDGKaKCAQYYPEKAG
|.| .|. ||. .|| . | ..|.|.     .|..|  |.   |. . ||.| ..  ..    .||||| . | . .|.|    |  |    ...|.|.|
kafkknlkknqsedvpildsnlvkleae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

EAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV----RTASGPVTVHCSAGIGRTGTFVAIEACLQ
.  ..|.  .     . ....  . .. |   .     . .  ... |..  || .  .| .    |      |. .. .    |.|| |.|..  . ..
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDN
 |..|||     . ...|. |. ...  .||. |  .|. |.| .
klqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
0042113 (Phosphotyrosine protein) phosphatases II 147-377 2.6e-63 209.0 In-house 5-242 (245) alignment 
Range on Protein: 147-377
Range on HMM: 5-242/245.0
IFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGE
.. .|..||||.|....| |||.||. |   | |||.|.||.|   .  ||.||| .. || |||||. . .  .||||.| .|.|. |||||.|.  ||
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

AMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLQ
 .|.| .|. .  |.  ..... |||.| |. .....   |.|  .||| .||...  ||..| .||.     ..||| ||||||.||||||.|.  .|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
 |   ....|  . . ||. | |..| . ||. | ..|...
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 147-377 1.8e-57 189.9 In-house 52-289 (298) alignment 
Range on Protein: 147-377
Range on HMM: 52-289/298.0
IFDANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKagE
  ..|  |||| |..  | .||.|..     ..||| | .... .   .||.||.   .|| ||||||.. . . |||| .. | .| |. .|.|..  .
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..g

AMTFGAWTILCsLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT---ASG--PVTVHCSAGIGRTGTFVAIEACLQ
. |.|  |.   |.... |..|.|.| | . .. ||. ...||  ||||..||. . ..| .|  ||.    .|  ||.|.||||.||.|||.||.. |.
ketygeitvsl.lskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvle

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
 .   . .|.. . ..||..|.|..|   ||. . .. ...
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 147-396 3.4e-55 182.3 In-house 42-299 (318) alignment 
Range on Protein: 147-396
Range on HMM: 42-299/318.0
IFDANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAge
. ..| .|||| ...  | ||| |..     . ||| |||..| ..   .| .|.  . |. ||||||   ..| |||| ...| ||||...|.|.|   
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..

AMTFGAWTILCSlEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS-----GPVTVHCSAGIGRTGTFVAIEACLQ
....|. ..  . |. . .. . |...|.. .. .. . .  |  ||||. ||.|.. || ..  |..|      ||..||||||.||||.|.|... |.
srsygklvvelk.eevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD-NGYWDDSDLDDRVELL
 . . . .|...| . ||. |   .|.. ||  . ..|... .  . . | ||| .|.. |
rikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 147-377 1.6e-43 144.1 In-house 44-287 (325) alignment 
Range on Protein: 147-377
Range on HMM: 44-287/325.0
IFDANPTKNRYKDVVCNDITRVILS---DGGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMlCEVMEDGKAKCAQYYPEKAGE
   .|  |||.|.||  | .||.|    | .. ||| |.|..       |. .|   .||. |.||.|.  ... .|.  .... || .||.|.|.. |.
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemgk

AMTFGAWTI-LCSLEDDkdANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV-------RT---ASGPVTVHCSAGIGRTGTFVA
. |||.  . | ..|.   .. ..| | |..|..|.   .| .. .||.|  |..   .|. .| .|       ..   ||.|. ||||||.||||.|..
sktfGglevklrtieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
. . |. . .  ..|..|  . ||. |   ..   ||. . . |...
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 147-379 5.9e-41 135.0 In-house 48-291 (310) alignment 
Range on Protein: 147-379
Range on HMM: 48-291/310.0
IFDANPTKNRYKDVVCNDITRVILS--DGGDGDYIHANYV--NGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkAGEA
 .  .  |||| |||| | .|| |       .||||||||  | | . || .||    |.||||||.   ..  |..|| |.|.|. ||  |.|   | .
aykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvt

MTFGAWTILCSLEDDKDANIIKR--TLSVRNVD------NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEAC
 |.|   .    |  .. .| .   |.   ||       | ||  .. ..   |||| ||.     .    . .   ||. ||||||..|... ||..  
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklk

LQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
.. |  |...|.      |..|||  || ..||. . .. | . .
idkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_PTPRA_pd Subfamily PTPRA 148-378 1.1e-52 174.0 In-house 55-295 (330) alignment 
Range on Protein: 148-378
Range on HMM: 55-295/330.0
FDANPTKNRYKDVVCNDITRVILSD--G-GDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgeA
 . |  |||. ... .| .|||||   |  . ||| | ...| .    || .||  . || |||||.   |.| |||| |. |  . |||||.|..   .
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG..l

MTFGAWTIlcSLEDDKD-ANIIKRTLSVRNVDNG----KEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----ASGPVTVHCSAGIGRTGTFVAIEA
.|.|  ..  ..||..   ..  | . |... ..    |. ... .| .||||  ||  .. .|..|  |..     .||..||||||.||||||....|
vtyGnirv..evedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda

CLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
 |. .   . .|. .. . ||. |.  .| | ||  . ..| .| 
vlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 148-374 8e-48 157.9 In-house 41-273 (315) alignment 
Range on Protein: 148-374
Range on HMM: 41-273/315.0
FDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEA
 . | .|||||...  | .||.|    |  | ||| | |.....    .| .||   |.| ||||||...|.. |||. .  |. | ||.||.|.. ...
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

MTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNgkEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASG----PVTVHCSAGIGRTGTFVAIEACLQIL
. ||.. .   |. . |.. ..| | .|. ..   . .   . . |||. |.. | .||...  |..  |    .. ||||||.|||| ...|. ... .
vefGsikv.ellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqi

TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
 ... .|.. . . ||. |   .| . .|  . ...
krtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_PTPN1_pd Subfamily PTPN1 148-370 1.1e-47 157.2 In-house 29-267 (290) alignment 
Range on Protein: 148-370
Range on HMM: 29-267/290.0
FDANPTKNRYKDVVCNDITRVILSDGgDGDYIHANYVN--GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAG-EAMT
...| ..|||.||   | .|..| .. | ||| |. |.   ..  .|||||  . ||  ||.|| . |.  .||| .|.| .. |||||.|..   ....
lpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekell

FG-AWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA------SGPVTVHCSAGIGRTGTFVAIEACLQI
.  .   .  .. ..  . . |.| . |.   . . . | |  .|||  ||.|  |.|..|. || .       ||. .||||||||.|||. ...||  
ledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvl

LTDGKE---LDLLGTCRALRNSRAGSIQVDIQ----YMAL
. . ..   .|.  .  .||. | | ||   |    |.|.
iekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPN14_pd Subfamily PTPN14 148-379 5.4e-37 122.4 In-house 46-297 (300) alignment 
Range on Protein: 148-379
Range on HMM: 46-297/300.0
FDANPTKNRYKDVVCNDITRVILSDG--GDGDYIHANY----VNGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEK--A
 . |  |||.|||.  . .|| ||     . .|| |      | | .  .| .||    || |||.||  .... |||| |  |||| |. .|.|..   
lpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk

GEAMTFGAWTILCSLEDDKDAnIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMAL---LRMLYIVRTA----------SGPVTVHCSAGIGRTG
 . ..|| . .   . .| |. .| ..| .. .  ..|  . ||  . |||. ||.        |...  || .          . || ||||||.||||
kktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

TFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
  .  .  .. |  ..|.|.  . . ||. |   .|   ||  . ..||.| |
vlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0049772 (Phosphotyrosine protein) phosphatases II 148-377 9.7e-34 112.9 In-house 43-279 (314) alignment 
Range on Protein: 148-377
Range on HMM: 43-279/314.0
FDANPTKNRYKDVVCNDiTRVIL--SDGGDGDYIHANYVNGLnAPFILTQGATAATVIDF----------WRMVV--HTKTAYIVM--------------
. .|..||||.|... | .||||   .. . |||.|.||.|    || ||| .  ||.||          ||||.    .. .|||              
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCEVMEDGkakcaqyypekageamtfgawtilcSLEDDKDANIIKrtlsvrN-------VdngKEHILKHLHTkSWPDRCVPnSTMALLRMLY
       |..... |                         .. . .|   .|      .       .   .....|.|..  .|| ..| ..  ....| 
aAlgKtpllildgng.........................neptaadlellk......eelydpelf...erlgikylri.pvpDgsap.lledfdefle

IVRT--ASGPVTVHCSAGIGRTGTFVAIEACLQILtdgkELDLLGTCRALRNSRA-----GSIQVDIQYMALVQILINY
....  . ||| |||.||.|||||||..  ..  |     ..|  . . .|. |      |.|.  .||    ..| .|
fieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 148-370 3.9e-29 96.2 In-house 42-228 (392) alignment 
Range on Protein: 148-370
Range on HMM: 42-228/392.0
FDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGkakcaqyypekagea
 . |  |||||...  | .||.|    |  | ||. | |......   .| .||  ||.. |||||| . ... |.|. .. |                 
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

mtfgawtilcsleddkdaniikrtlsvrnvdNG-KEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVT----VHCSAGIGRTGTFVAIEACLQI
                               .| . .     |   |||. ||. | .||...  |..  |  |    .|||||.||||  ..|.. .  
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

LTDGKELDLLGTCRALRNSRAGSIQVDIQYMAL
    . .|..     .|. |   .|.. ||  .
akktrmvdvfnfvtnirrkrpymvqtkeqyafi
subfamily_PTPN12_pd Subfamily PTPN12 149-375 3.7e-56 185.2 In-house 38-274 (290) alignment 
Range on Protein: 149-375
Range on HMM: 38-274/290.0
DANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
. | .||||||..  | .|| ||      . ||| ||...| .    .| .||  ..|. |||||. ....  .||.|...| || ||..|.||. .|..
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeel

TFGAWTILCSLEDDKDANIIKRTLSVRNVdnGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILT
.||. .. .. |.  | ... ||| |..   ....... .| ..|||. ||.|.  ||...  ||.     . |. ||||||.||||| .||.   ..| 
efgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellk

DGKE---LDLLGTCRALRNSRAGSIQVDIQYMALVQILI
..|    ||.    . ||. ||  .|   ||  . . ..
aekipeeldvfdlvlelrkqraalvqtkeqyelvykava
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 149-378 1.9e-55 182.6 In-house 53-289 (305) alignment 
Range on Protein: 149-378
Range on HMM: 53-289/305.0
DANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGLNAP---FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTF
| . |||||.|| |.| . | |..    ||||||||     |   || .||    |. .|| ||.. |   |||||  .| || |||||.|   || ...
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

GAWTILCS----LEDDKDANIIKRTLSVRNvDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDG
 .  ..         ..||.|   .| .     ...  ..||.   |||| ||   .. | .|  .| .  |. |||||||||||| ||||  |. ... 
ksgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaen

KELDLL-GTCRALRNSRAGSIQVDIQYMALVQILINYG
|.   .    .|||. || ||| |.||. . ....|| 
kpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 149-393 2.2e-53 176.4 In-house 46-299 (319) alignment 
Range on Protein: 149-393
Range on HMM: 46-299/319.0
DANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKagEAM
. | .||||....  | |||.||.     . ||| |....| .    || ||.  . |. |||||| . ..  .|||... | .| |. .|.||.  . .
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nfe

TFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGK-EHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLQI
..| ...   .|... ...|.| |....  .      .|| . ..|||  ||.....|| .|  .|       |||..||||||.||||||....| |. 
eyGrliv.tleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamler

LTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNG-YWDDSDLDDRV
.     ||.  | . ||  |   .|   ||  . ..|... .      .  || ||.
vkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl
subfamily_PTPN23_pd Subfamily PTPN23 149-378 4.5e-49 161.8 In-house 41-280 (288) alignment 
Range on Protein: 149-378
Range on HMM: 41-280/288.0
DANPTKNRYKDVVCNDITRVILSdGGDGDYIHANYVNGLNA---PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTF
  ...|||..|..  | .|| |  |.  ||| | .|..| .   .|| ||.  . |. |||.||.. |.  |||| .  | || |...|.||. ||...|
klyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GAWTILCSLEDDKDaNIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEACLQI
|. .. .. . . . . ..|.|...  |. . . ..||...|||.  ||.|   ||..|  |..        .  |. ||||||.||||.|  . | .. 
gdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

LTDGKEL-DLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
|. |. | |..   . ||. |  ..|   |.  . .. ... 
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPRK_pd Subfamily PTPRK 149-372 9.9e-49 160.8 In-house 41-271 (314) alignment 
Range on Protein: 149-372
Range on HMM: 41-271/314.0
DANPTKNRYKDVVCNDITRVILSD--GG-DGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgeaM
| | .|||..|..  | .||.|    |  . ||| |..... . |  || |||    || ||||.| . ..| |||| |..| |. || .|.||..   .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt...e

TFGAWTILCsLEDDKDANIIKRTLSVRNVDNGKE--HILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----ASGPVTVHCSAGIGRTGTFVAIEACLQI
..|   . . .| . .|....|...|...  |.|  .......  .|||  ||.|  .||...  | .      |.. |||||| ||||||.||.  |..
vygdikvel.vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldm

LTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
.   . .|.  . ..||...   ...  ||. . .
ieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 149-372 4.6e-48 158.6 In-house 41-270 (515) alignment 
Range on Protein: 149-372
Range on HMM: 41-270/515.0
DANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
. | .|||||...  | .||.|    |  . ||. | |......   .| .||   |.| ||||.|.. ... |.|. .  |. | ||..|.|.| |...
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

TFGAWTI-LCSLEDdkDANIIKRTLSVRNVDNgkEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASG----PVTVHCSAGIGRTGTFVAIEACLQIL
 ||   . | |||   ... |||.| |   |.   . .   | . |||. ||. | .||...  |..  |    |. .|||||.|||| ...|. ..   
kfGsikvelvslea..ctggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
 ... .|.. . . .|. |   .| . ||  . .
kttrmvdvfnfvtnirqkrpylvqtqeqyafiyg
subfamily_PTPRG_pd Subfamily PTPRG 149-376 1.7e-47 156.9 In-house 45-285 (563) alignment 
Range on Protein: 149-376
Range on HMM: 45-285/563.0
DANPTKNRYKDVVCNDITRVILSD--GGDG--DYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGEA
  |  |||| ..|  | .|| ||.  | ..  ||| |||..| .    || |||. . |. |||||.   ..| |||. .. |.|. || .|.|.   |.
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..des

MTFGAWTILCSlEDDKDANIIKRTLSVRN--VDNGK----EHILKHLHTKSWPDRCVPNSTMALLRML----YIVRTASGPVTVHCSAGIGRTGTFVAIE
.|.|| ..    | .. |   .|||...|  ....|    |.  .. |  .||| .||....  | .     .  ... ||..||||||.|||||.....
etygalqvtli.eeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld

ACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
. |. . . .  ...|. . .|  |   .|   ||. | ..|..
tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle
subfamily_Ptp69D_pd Subfamily Ptp69D 149-391 1.9e-47 156.9 In-house 46-300 (307) alignment 
Range on Protein: 149-391
Range on HMM: 46-300/307.0
DANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKagEAM
. |  ||||.|..  | |||.|.      | ||| |....|   .  ||  |.   ||. |||||.   .   |||| .. |  ..|||.|.|.   . .
kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..dev

TFGAWTILCSlEDDKDANIIKRTLSVRNVDN------GKEHILKHlHTKSWPDRCVPNSTMALLRMLYIV----RTASGPVTVHCSAGIGRTGTFVAIEA
 .|   . .  . .|  . |.|.|.| ....       . ..... | ..|.|  ||... .||.... |    ..  .|..|||||| ||.|.|||.. 
qygdilvklv.seekhsdyiiReldvskkkeesgevedsrkvvqy.hytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

CLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK-DNGYWDDSDLDD
 || |   ...|.  | . ||. |   .|   ||. | . |..| .  .   |  ||.|
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled
subfamily_PTPRN_pd Subfamily PTPRN 149-368 2.9e-32 106.6 In-house 54-282 (297) alignment 
Range on Protein: 149-368
Range on HMM: 54-282/297.0
DANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNG---LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEa
. | .|||.|.|.  | .|| |..     . ||| |  .      .. .| |||  |.|| |||.|| .  .. ||.|... |.|  .|..|.|..  | 
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.

mTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLY----IVRTASGPVTVHCSAGIGRTGTFVAIEACLQIL
 ..... .    |     . . |.. ..|... .   .  .|  |||.. || |. .|| .        |  | |. ||||.| ||||....|.  |. |
.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrl

TDG-KELDLLGTCRALRNSRAGSIQVDIQYM
. | ||.|.  |   ||. |.| ..   |. 
lkGvkeidiaatlehlrdqrpglvktkdqfe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 149-295 6.8e-11 36.2 In-house 94-238 (244) alignment 
Range on Protein: 149-295
Range on HMM: 94-238/244.0
DANPTKNRYKDVVCNDITRVILSDGGDGD-YIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGkakcaQYYPEKagEAMTF
  |  |||    .  |. || || |  |. || | .|  |   | .||||   | | .|||.|..  .   .|.|  | |.      .|.|.   | . .
pnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds..eplew

GAWTILCSLEDDKD-ANIIKRTLSVRNVDNGKEHILKHLHTKSWP-DRCVPN
    |  .| |  .  ||    | .    |     |  .    || |   ||
yeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpn
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 150-377 8.5e-57 187.4 In-house 46-278 (288) alignment 
Range on Protein: 150-377
Range on HMM: 46-278/288.0
ANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkAGEAMT
 | .||||....  | .|| | .   . . ||| |.|..| .    .| |||  |.|| |||..|  .||  |||| |..|.|| || .|.|. |..   
vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpkn

FGAWTILCSlEDDKDANIIKRTLSVRnvDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTD
.|  |.    |. .  ....|.| .    ...|  ..... ..|||  ||.|.. || .|..| .|    .||..||||||.||||||.|..| .. .  
yGsvtvtlv.eskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee

GKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
 . .|..||   ||..||  .|.  ||. . ..|.. 
edyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPN6_pd Subfamily PTPN6 150-380 2.5e-52 172.8 In-house 53-299 (306) alignment 
Range on Protein: 150-380
Range on HMM: 53-299/306.0
ANPTKNRYKDVVCNDITRVIL-SDGGDG-DYIHANYVN----GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
 | .||||| ..  | ||||| ...  | ||| |||..    | .. .| |||.  .|| ||||||.  ..  |||. . .| || |||.|.|..  . .
enkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

tFGAWTILCSLEdDKDANIIKRTLSVRN-VDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEAC
 .|  .. .  | .. |. | |.||| .  ....|. . ..| |||||  ||... |.| .|  |..         .||. |||||||||||||. |.. 
.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

LQILTDG---KELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
|....      ..|.  . . .|. | | .|.. ||  . ... .| . 
lkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 150-377 5.3e-52 171.5 In-house 8-241 (250) alignment 
Range on Protein: 150-377
Range on HMM: 8-241/250.0
ANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAkCAQYYPEKagEAMT
.|  |||| |..  | .||.|       . ||| | ...| .    || |||   ||. ||||||.. |.. |||| .. | .|  . ||.| .  .| .
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaek

FGAWTILcSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLQILT
.|  |.   |.... |...||.| . .  . .| |...||  .|||..||. . | | .|  |..      ..|| |.||||.||.|.|.||.| |. | 
yGdvtvs.llskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
  | .|.    ..||. | ....   ||. . .|....
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-381 1.6e-48 159.9 In-house 37-280 (287) alignment 
Range on Protein: 150-381
Range on HMM: 37-280/287.0
ANPTKNRYKDVVCNDITRVILSDGGD--GDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKaGEAMTF
|.  |||| ||.  | |||.||  |.   ||| |||| . .    || .||  |||| ||||.|..|..| ....   .|... || .|.||.    |  
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV-------RTAS--GPVTVHCSAGIGRTGTFVAIEACLQ
| ...     | |. .   |.| . ...  . ...| |.  ||||. .. ....|.|.   |       | ||  ||. ||...||||.|...|. ....
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDN
 | |  ..|   .   ||. ||. .|  .|.  |.. |. | | |
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 150-375 3e-47 156.1 In-house 48-276 (315) alignment 
Range on Protein: 150-375
Range on HMM: 48-276/315.0
ANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKageAMT
 |  |||| ...  | .|| |       . ||. ||...| | .  .| .||  .|.| ||||.| . . . |||| ...|. | |. .|.|.|    ..
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kvi

FGAWTILCSLEdDKDANIIKRTLSVRNVDNGKEHIlkHLHTKSWPDRCVPNSTMALLRMLYIVR---T-ASGPVTVHCSAGIGRTGTFVAIEACLQILTD
.|  |.    | ..  ..  |||||   || .| .   ||  ||||  ||..|..|. .   |.   | . |.. ||||||.||||||....| |. .  
yGkitvtrkse.evnteytvrtlsvvfgdnirevv..qlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea

GKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
 . .|.   .. .|. | . .||  ||  . ..|.
enaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 150-378 1.6e-44 146.7 In-house 36-269 (281) alignment 
Range on Protein: 150-378
Range on HMM: 36-269/281.0
ANPTKNRYKDVVCNDITRVILS----DGGDGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
 |  |||| .. | ||.|| |     .    |||||||.    |.  .|||||    |  |||||. . .|. |||||...|  . |||.|.| .|  ..
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

TFGAWTIlcSLEDDKdANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGK-
 |   ..  | ||    |    |  .    .|. ... |   | |||  ||.|.  .|..|  .|. | |  .|||||.||.||..|.| .|| .     
qfdklsv..syedst.vnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshft

ELDLLGTCRALRN-SRAGSIQVDIQYMALVQILINYG
  |.      ||   || |.|   ||| . ..|...|
lpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_CG7180_pd Subfamily CG7180 150-376 2.7e-35 116.5 In-house 41-288 (296) alignment 
Range on Protein: 150-376
Range on HMM: 41-288/296.0
ANPTKNRYKDVVCNDITRVILSD--G-GDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKaKCAQYYPEKAgeAMT
 |  |||. .||  | .||.|.   |  . ||| | ||...   . .| |.. .  || .|||.|   ..  .|.|.....  | .. .|.|.|.     
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keq

FGAWTiLCSLEDDKDANIIKRTLSVRNV----------DNGKEHILKHLHTKSWPD-RCVPNSTMALLRMLYIVRT---------ASGPVTVHCSAGIGR
.|    .  .| .. ||. .||. .              . .. |.|... . |.    || || ||. ..  ||.           ||| |..| | .|
ygeif.veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

TGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
.| ..||.|.|. .   .|.|. .  . ||.|| . ..   .|. . ..| .
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_ptpA1_pd Subfamily ptpA1 150-332 1.6e-26 88.0 In-house 46-250 (418) alignment 
Range on Protein: 150-332
Range on HMM: 46-250/418.0
ANPTKNRYKDVVCNDITRVILS---DGGDGDYIHANYVNGLN-APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGE-A--
 | .|||| ...  . ||| |    |    ||| |||..|     || |||    |. ||||||   .   ||||    |. . || .|.||. |     
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

------MTFGAWTI-LCSLEDDKDANIIKRTlsVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----------ASGPVTVHCSAGIGRT
        ||.... |  . .| . .|| |   .|   .|. . . . . . |||. .|. |  . ..|. .               |. ||||||.|||
iygngnevfgtysvelveviqdpereiitrn..irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFVAIE
|||..  
gtfctav
Y_phosphatase Protein-tyrosine phosphatase 151-375 3.4e-73 241.3 Pfam-A 1-234 (235) alignment 
Range on Protein: 151-375
Range on HMM: 1-234/235.0
NPTKNRYKDVVCNDITRVIL-SDGGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA
| .||||||... | ||| | ...|. |||.||||.|   .  ||.||| .  |. ||||||.. |. .||||....| |. |||||.||. .| .|.| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

WTILCS-LEDDKDANIIKRTLSVRNVDNGK-EHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS----GPVTVHCSAGIGRTGTFVAIEACLQILTDG
 .. .   | ....... |.|.... .. . ....|.|| ..|||..||.|. .||...  |.. .    |||.||||||.||||||||....|. |...
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

KELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
.|.|.| ... ||..|.|..|   ||..|.....
eevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 151-375 3.4e-73 241.3 In-house 1-234 (235) alignment 
Range on Protein: 151-375
Range on HMM: 1-234/235.0
NPTKNRYKDVVCNDITRVIL-SDGGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA
| .||||||... | ||| | ...|. |||.||||.|   .  ||.||| .  |. ||||||.. |. .||||....| |. |||||.||. .| .|.| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

WTILCS-LEDDKDANIIKRTLSVRNVDNGK-EHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS----GPVTVHCSAGIGRTGTFVAIEACLQILTDG
 .. .   | ....... |.|.... .. . ....|.|| ..|||..||.|. .||...  |.. .    |||.||||||.||||||||....|. |...
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

KELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
.|.|.| ... ||..|.|..|   ||..|.....
eevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 151-378 1.7e-50 166.5 In-house 20-264 (270) alignment 
Range on Protein: 151-378
Range on HMM: 20-264/270.0
NPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGL---NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGE--A
... |||.|.. .  |||.|..        || ||||.|    .. .| ..| ...|. .||||....|.  |||. ...|.|. ||..|.|....|  .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

MTFGAWTIlCSLEDDKDANIIKRTLSVRnvDNGKEHILKHLHTKSWPDRCVPNSTM------ALLRMLYIVR-----TAS-GPVTVHCSAGIGRTGTFVA
...|  .. ..|.. |.   |.. | ..  ..|.|. | | . ..|||. ||...        ||.||  ||     ..  .|. ||||||.|||||..|
ledgkikv.lalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
.. ....|   |..|.|   ..||. |   .|   ||  | . ...| 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 151-375 1.1e-46 154.3 In-house 51-281 (297) alignment 
Range on Protein: 151-375
Range on HMM: 51-281/297.0
NPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKaKCAQYYPEKAgeAMTFGA
|  |.|||...  |  ||.|   .|    ||. | .|.| .  .| ||    ||| |||.||.. ... |||| .  |  | |||.|...|.   .||| 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGd

WTILCSLEDdKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPN--STMALLRMLYIVR-----TASGPVTVHCSAGIGRTGTFVAIEACLQILTD
 ... .  . .    |||.|.|.. .. .....|  .  .|||. |..  |. .|| ..  ||     .|.||. |||.||.|||| ...|. ..    .
vsvvllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr

GKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
 ||.|..|. . ||..|   .| . ||  . ....
ekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 151-374 5.1e-39 128.9 In-house 3-235 (237) alignment 
Range on Protein: 151-374
Range on HMM: 3-235/237.0
NPTKNRYKDVVCNDITRVILSD-GGDGDYIHANYVNGLN---APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgEAMTFG
|  |||| ..|. | .||.|   |.. ||| |.|..|..     .| .||   ..  |||.||   | . ||||  ..|  . || .|.|.   .  ..|
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaayg

AWTI-LCSLEDDKDANIIKRTLSVRNVDNGKeHILKHLHTKSWPDRCVPNSTMALLRMLY--IVRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILT
 .|. |.  |.  |  .   .||.|   ..   ...  .  ||||| ||. | ||||.    | |.     |||  .|||||.|||| |. |.| |.   
vltvslkkkeefsdytvrslllskrltlkev.rlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
. | .|.     .. . |   ||.  ||. . | .
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 151-376 3.7e-38 126.3 In-house 1-169 (182) alignment 
Range on Protein: 151-376
Range on HMM: 1-169/182.0
NPTKNRYKDVVCNDITRvilsdggDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCevmedgkakCAQYYPekageamtfgaw
| .||||.|....| .|       | |||.||.. |   .  ||.||| .  || ||.||. . .  .||.|.         . .|.|            
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

tilcsleddkdaniikrtlsvrnvdNGKEHILKHLHTKSWPDRCVPNsTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQIltdgkELDLLG
                         .  |.   ...  .||| .||. .  ||... .|.  .||| ||||||.|||||.||.  ...      ...|  
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

TCRALRNSRAGSIQVDIQYMALVQILIN
. . .|. | |...   ||  | ..|  
avklvrsrRpgmvitpnqyfflqlalle
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 151-374 9.6e-36 118.1 In-house 48-275 (439) alignment 
Range on Protein: 151-374
Range on HMM: 48-275/439.0
NPTKNRYKDVVCNDITRVILS---DGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKakcaqYYPEKAgeAMTF
. ||||||||.  | |||.|          || |||..|   .  .| ||| .  |. ||||.|.. ||. ||||....|  |     |.| .|   . .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda..evcy

GAWTILCSLEDDKDANIIkRTLSVR-NVDN-GKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA-----SGPVTVHCSAGIGRTGTFVAIEACLQIL
|  .. .  . .    .| | . |  . |.  ||. . ..|  .|||. ||  .  .| .|  . .|      ||| ||||||.||||| .|.. .|. |
gdiavrvdrnielpnyvi.rgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql

TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
   ...|. |  . ||. |   .|   ||. . . .
klenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 151-370 1.1e-34 114.7 In-house 8-233 (239) alignment 
Range on Protein: 151-370
Range on HMM: 8-233/239.0
NPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVN---GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMT
| .|||| ..|  | .||.|   |.    ||| |.|.    |    .| |||. ...  |||||. . . . ||||  ..|  | || ||.|. . .   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

FGawTILCslEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTD
.     |   . .  |. | ||. . .| . .|. . . |   |||. ||. . |.| .   .       . |  .|||||.||||.|. |.| |.    
lr..vtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

GKELDLLGTCRALRNSRAGSIQVDIQYMAL
 | .|..   .|.|. |   .|   ||. .
qktvdifnyvkairedrphmvqtseqyvfi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 151-370 1.1e-34 114.6 In-house 7-232 (239) alignment 
Range on Protein: 151-370
Range on HMM: 7-232/239.0
NPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVN---GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMT
| .|||| ..|  | .||.|   |.    ||| |.|.    |    .| |||. ...  |||||. . . . ||||  ..|  | || ||.|. . .   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

FGawTILCslEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTD
.     |   . .  |. | ||. . .| . .|. . . |   |||. ||. . |.| .   .       . |  .|||||.||||.|. |.| |.    
lr..vtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

GKELDLLGTCRALRNSRAGSIQVDIQYMAL
 | .|..   .|.|. |   .|   ||. .
qktvdifnyvkairedrphmvqtseqyvfi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 153-367 7.8e-39 128.2 In-house 52-270 (301) alignment 
Range on Protein: 153-367
Range on HMM: 52-270/301.0
TKNRYKDVVCNDITRVILSDGGDGDYIHANYVN--GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTI
 |.||. | |.  | | . . |    ||||...  |    || |||   .|  ||| |.|. .   ||||.. .|. . ||..|.| | .| .  | ..|
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfki

LCSLED-DKDANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLG
    ..   . .|.|||| |..   . . . . |   ..|.|| ||.| . |  .. .|. .  |. |||||||||. .|.. |   . .   ....|  
kiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptielte

TCRALRNSRAGSIQVDIQY
. . ||. |  ..|   | 
alkhlrehrwngvqtnsql
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 153-303 1.8e-25 84.4 In-house 35-189 (297) alignment 
Range on Protein: 153-303
Range on HMM: 35-189/297.0
TKNRYKDVVCNDITRVILSDGG-DGDYIHANYVNGLNAP----FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA
 ||||.|..  | ||| |  .  . ||| |.||   . .    .||.|| . ||| |||..|..     |||.... |||. ||| |.|.  .| .. | 
rknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

WTI--LCSLEDDKDANIIkRTLSVRNVdnGKEHILKHLHTKSWPDRCVPNSTMALLRM
  .  | |  |. |  |.   | .      ..  ..|    ||||  ||.    | |.
vvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_CG42327_pd Subfamily CG42327 153-309 6.4e-21 69.3 In-house 30-192 (319) alignment 
Range on Protein: 153-309
Range on HMM: 30-192/319.0
TKNRYKDVVCNDITRVILSDGGDGD---YIHANYVNGLNA---PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMT--
 |.|. .||    |||.|   || |   |..|.|| | .     .| .| .   .  ||||.|   ..  || |... | |  .||.|.| |..   |  
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FGAWTILCSLEDDKDANIIkRTLSVRNVDNGKEHILKHLHTkSWPDRCVPNSTMALLRMLYIVRT
.| . .     . ||  .|  || ...||. .   | |     |..  || .  ||. ||  ||.
yGdilvtlkgrevkdryai.stlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 153-239 3.9e-13 43.8 In-house 49-154 (350) alignment 
Range on Protein: 153-239
Range on HMM: 49-154/350.0
TKNRYKDVVCNDITRVILSD-----------GGDGDYIHANYVNG------LNAPF--ILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQ
.|||||...  . .||.|                 ||| |||..        |. |  | ||. .  || ||...... |   |..| . .| .  || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YYPEKA
|..| .
YWqegs
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 154-385 2.8e-37 123.1 In-house 46-283 (312) alignment 
Range on Protein: 154-385
Range on HMM: 46-283/312.0
KNRYKDVVCNDITRVILSdGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGE--AMTFGAWT
 ||| .. | |  |  |. | .  |||||.|.    |  |. |||.   |.  ||....   .. |..|| ..|||  |||.|  .  |         .|
lnrypniqcwdrgrftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

ILCS---LEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDL
  |.   .      .| .| | |     |.|  |.|    ||||  .|.|  . ||.|  |.    ||  |||||.|||||.. ||. .  |   .  ..
eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnv

LGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWD
  .   ||. || |..|  ||.  .......   .| . 
kdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 166-367 8.6e-38 125.1 In-house 33-248 (290) alignment 
Range on Protein: 166-367
Range on HMM: 33-248/290.0
TRVILSDGGD---GDYIHANYVNG-LNAPFILTQ-------GATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKA----KCAQYYPEKAGEAMTFGAWTI
|||.| . |     ||||||.|    .  .||||          ..|. .|| |.   |   .|||||..|  .      ||.|.||..|| ..|.  |.
trvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

LCsLEDDKDANIIKRTLSVrNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT-DGKELDLLGT
 |  .  |. ....|.| | . |...|. ..|   |.| .. |...|  || ..  |..   || |||  || |  .. ||.   | .    ... |   
kC.kskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

CRALRNSRAGSIQVDIQY
  |||. ||  |. ....
lkalrkqralaitsalel
0046846 (Phosphotyrosine protein) phosphatases II 169-375 6.6e-34 112.6 In-house 5-170 (176) alignment 
Range on Protein: 169-375
Range on HMM: 5-170/176.0
ILSDGGDGDYIHANYVNGlnAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMtfgawtilcsleddkdaniikrtls
.| ...| |||.||.. |  . .| ||| .  |. ||..|. . .  ..|.|.| .| |. ||..|.||  .. .                         
llgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

vrnvdngkehilkHLHTKSWPDRCVPNStMALLRMLYIVRTAS---GPVTVHCSAGIGRTGTFVAIEaclqIL-TdGKELDLLGTCRALRNSRA-GSIQV
             . .   ||| .||..  .||..| ..|.|    ||| ||||||||||||.||.     .| . .| |... . . .|. |  |..| 
.............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llel.ekglsveealalvreqRplgavqt

DIQYMALVQILI
. ||  | . . 
peQyrflyefel
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 169-289 1.4e-06 22.7 In-house 11-122 (130) alignment 
Range on Protein: 169-289
Range on HMM: 11-122/130.0
IlsdggDGDYIHANYVN--GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGkakcaQYYPEKagEAMTFGAWTILCSLEDDKDANIIKR-
      . .||.|..|   |  | ..||| . |.| .|||.|...     .|.|  | |.      .|.|.   | . .    |. .| | .. . ||  
q.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds..ePlewyeediivtltdrdefknikas

TLSVRNVDNGKEHILKHLHTKSWP
 | . .  |   . |  ..   ||
nleiesdlneshqaltmfqisnwp
0044763 (Phosphotyrosine protein) phosphatases II 173-376 9.7e-26 85.9 In-house 15-169 (178) alignment 
Range on Protein: 173-376
Range on HMM: 15-169/178.0
GGDGDYIHANYVNGLnapFILTQGATaatvIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGeamtfgawtilcsleddkdaniikrtlsvrnv
   .|||.|... .    ..|..  .     |.....   .  .||.|.| .| |. || .|.||.||                                
lersdyinaseilpg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

dngkehiLKHLHTkSWPDRCVPNSTMALLRMLYIVR----TASGPVTVHCSAGIGRTGTFVAIEACLQIltdgkELDLLGTCRALRNSRAgSIQVDIQYM
       ...||.  .|| .||...  .|... ...    .  ||| ||||||.||.||.||.  ...       |.|    . .|. |   .. . |. 
.......iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlr

ALVQILIN
 | ..   
qLyefelr
0043147 (Phosphotyrosine protein) phosphatases II 175-371 5.7e-32 106.2 In-house 4-154 (172) alignment 
Range on Protein: 175-371
Range on HMM: 4-154/172.0
DGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVmedgkakcaqyypekageamtfgawtilcsleddkdaniikrtlsvRNV
. |||.|.|...   |  || ||| .  |. |||||. . .  .||.|.|                                                . 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lyd

DNGKEHILKHLHTKSWPDRCVPnSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLqiltdgKELDLLGTCRALRNSRAGSIQVDIQY
  . |.   ...  .||| .|| ..  ||..| ....      .||| ||||||.|||||.||.  .|      . |.|. . . .|. | |..| . ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

MALV
. | 
rfly
0051429 (Phosphotyrosine protein) phosphatases II 176-386 1.8e-37 124.8 In-house 4-256 (272) alignment 
Range on Protein: 176-386
Range on HMM: 4-256/272.0
GDYIHANYVNGLnAP------FILTQGATAATVIDFWRMvVHTKTAYIVMLCEVMEDGKAKCAQYYP----------EKAGEAMTFGAWTILCSLEDDKD
..||.|..|.|.         .....| . .|. ||||.  . .  .||.|....| |. || .| |          . . . ...||... .  |  ..
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

ANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTmaLLRMLYIVRTaSGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELD--------LLGTCR
  |. . | .. ...|. . . |||  .|||..|| ..  ||..| .... .||| ||||||..||||.||.  .|. ...   .|        |... .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

ALRNSRAGSIQVDIQYMALVQILINY-----------------------GKDNGYWDD
 ||  |.|..| . ||. | ..|...                       |  .||  |
elraqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyGsvegYLrd
0036282 (Phosphotyrosine protein) phosphatases II 176-372 4.1e-34 113.2 In-house 2-164 (174) alignment 
Range on Protein: 176-372
Range on HMM: 2-164/174.0
GDYIHANYVNGLNAP--FILTQGATAatvidFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkageamtfgawtilcsleddkdaniikrtlsvrnVD
 |||.|.....   .  .|..|| .|     ||.|. . .  ..|||.| .|.|. || .|.||                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

NGKEHILKHLHTKSWPDRCVPNSTMaLLRMLYIVRTA-----SGPVTVHCSAGIGRTGTFVAIEACLQILTdGKELDLLGTCRALRNSRAGSIQVDIQYM
.  |.   ...   |||..||.... ||... .|..|     .||| ||||||.|||||.||.  .|. |   .  | | . |.||. | |..| . ||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

ALVQ
 | .
flyy
0051082 (Phosphotyrosine protein) phosphatases II 177-371 9.7e-27 88.8 In-house 4-146 (151) alignment 
Range on Protein: 177-371
Range on HMM: 4-146/151.0
DYIHANYVNGLnapFILTQGATAatviDFWRMVVHTKTAYIVMLCEVMEDGkaKCAQYYPEKAgeamtfgawtilcsleddkdaniikrtlsvrnvdngk
|||...|| |    .....| .|    ||.... . .  .||.|.. .| |  .|..|.||                                       
dyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.....................................

eHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA-SGPVTVHCSAGIGRTGTFVAIEACLQIltdgkeLDLLGTCRALRNSRAGSIQVDIQYMALV
 . ..|..  .|||  .| |. |.|..| ...   .||| ||||||.|||||.||.  .|.       ..|  . . .| .| |..|   |.. . 
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql
subfamily_eak_pd Subfamily eak 187-295 4.7e-12 39.9 In-house 91-196 (332) alignment 
Range on Protein: 187-295
Range on HMM: 91-196/332.0
LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEdDKDANIIKRTLSVRNVDngKEHILKHLHTK
.   .|||  |    |  ||.||.  |.  ||.| | .| .  |  .|.|.|. | . || . . .     | ...  | | ..  .  . | ..| .  
vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGn..ethrvlhykvf

SWPDRCVPN
 | .  .| 
Gwtettlpk
0049260 (Phosphotyrosine protein) phosphatases II 189-371 4.9e-31 102.9 In-house 9-143 (152) alignment 
Range on Protein: 189-371
Range on HMM: 9-143/152.0
APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYpekageamtfgawtilcsleddkdaniikrtlsvrnvdngkehilkHLHTKSW
 .|| ||| .  |. |||||. . .  .||||.| .|.|| ||.||.                                              . .   |
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlpw

PDRCVPNSTMALLRMLYIV----RTASGPVTVHCSAGIGRTGTFVAIEACLqiltdgKELDLLGTCRALRNSRAGSIQVDIQYMALV
|| .||.... || .| ..    .  .||| ||||||.|||||.||.  .|      . ..|. . . .|. | |...   |.. | 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-252 3.2e-07 24.0 In-house 237-295 (440) alignment 
Range on Protein: 190-252
Range on HMM: 237-295/440.0
PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEdgkAKCAQYYPEKAgEAMTFGAWTILC
 || ||    .||.||||.|   . . |.|| .. .     |. |.| ..  ..||| .|.  
afiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt.rsvtfgpftvgh
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 191-368 1.8e-14 48.4 In-house 6-193 (198) alignment 
Range on Protein: 191-368
Range on HMM: 6-193/198.0
FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDD-KDANIIKRTLSVRNVDNGKEHILKHLHTKSWP
.| || .   |. |||.||  | . .|||. .   . .|  . |.|     .  .|. .. .       |  |    |.           . |    || 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DRCVPNSTMALlRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKE--LDLLGTCRALRNSRAGSIQVDIQYM
..  || .. .  ..   |            || |||| | | || |||..  ..   . |   .||.  .. ||..| | |    .| 
ekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 191-368 2e-14 48.3 In-house 7-194 (199) alignment 
Range on Protein: 191-368
Range on HMM: 7-194/199.0
FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDD-KDANIIKRTLSVRNVDNGKEHILKHLHTKSWP
.| || .   |. |||.||  | . .|||. .   . .|  . |.|     .  .|. .. .       |  |    |.           . |    || 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DRCVPNSTMALlRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKE--LDLLGTCRALRNSRAGSIQVDIQYM
..  || .. .  ..   |            || |||| | | || |||..  ..   . |   .||.  .. ||..| | |    .| 
ekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 195-377 3.2e-06 20.0 In-house 124-308 (346) alignment 
Range on Protein: 195-377
Range on HMM: 124-308/346.0
QGATAATVIDFWRMVVHTKTAyIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWtILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVP
|    . | ||| |. . .   .| |    .  |   .  . .. |     |   ..     |   .  . |. |    |    | .  |   |     |
qmenesfvedfwymiyqeqih.lvylmvpddklkntttslfndenggyqytgkm.finnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqp

NSTMALLRMLYIVRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
  |. ...|..   .     .  | |    | ||. .|.     .. | .| | ...   ..... | |...   || ..  |...|
pktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 200-372 2.4e-29 96.8 In-house 102-282 (302) alignment 
Range on Protein: 200-372
Range on HMM: 102-282/302.0
ATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTIL-CSLEDDKDANIIKRTLSVRNVDNG-------KEHILKHLHTKSWPDR
 |.  .| .. . ..| .| ||...||.. |||.|| .| |. ..|| .|.   |...| .    |... . .|.         ... .. |.  .||| 
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

CVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
  |. . . | .|    .    | ||||||.|||||.|||   .|. .  |  |||     .|. | |..| . | . |. 
GapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 200-368 9.4e-29 95.2 In-house 39-211 (255) alignment 
Range on Protein: 200-368
Range on HMM: 39-211/255.0
ATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLeddKDANIIKRTLSVRNV-D-NGKEHILKHLHTKSWPDRCVPNST
 ||  |....| |||  .||||.  |.|. || .|.| .  | . .   .. ..      |... ||| .        | | .|| . | |...  |. .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

MALLRMLYIVRTAsGPVTVHCSAGIGRTGTFVAIEACLQ------ILTDGKELDLLGTCRALRNSRAGSIQVDIQYM
  .| .| .|| .  .| ||||.||||. .|| .|   |        |.  ||| |   . ||..|...|.  .|  
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqla
subfamily_hpo-7_pd Subfamily hpo-7 201-368 2.1e-26 87.4 In-house 46-217 (263) alignment 
Range on Protein: 201-368
Range on HMM: 46-217/263.0
TVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDkdaNIIKRTLSVRN-VD-NGKEHILKHLHTKSWPDRCVPNSTM
|.  |....| |||  .||||.  |.|. || .|.| .  | . .   .. ..   .   .....|| . . ..   | | .||   | |...  |. . 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpelar

ALLRMLYIVRTAsGPVTVHCSAGIGRTGTFVAIEACLQ------ILTDGKELDLLGTCRALRNSRAGSIQVDIQYM
  |..| ..|    .. ||||.||||.  |. .|   |        |.  ||| |   . ||.||...|.  .|  
eilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLa
0048076 (Phosphotyrosine protein) phosphatases II 233-374 7.7e-21 69.7 In-house 1-139 (145) alignment 
Range on Protein: 233-374
Range on HMM: 1-139/145.0
QYYPEKAGEAMTFGAWTILCSLEDDKDANiIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA---SGPVTVHCSAGIGRTGTFV
.|.| .  . . .| ..  ..||  || . |.. |.. .  .. |.   ...  .|||..||...  ||..| ....|    ||| ||||||.|||||.|
pywpseilpglylgslptaldlellkdlg.ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

AIEACLQiltdgKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
|.  .|.     . ..|  . . .|. | |... . |.  | . .
aaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 241-372 3.9e-19 64.3 In-house 9-139 (144) alignment 
Range on Protein: 241-372
Range on HMM: 9-139/144.0
EAMTFGAWTILCSLEDDKDANIiKRTLSVRNVDNGKEHILK--HLHTKSWPDRCVPNSTMALLRMLYIVRTA---SGPVTVHCSAGIGRTGTFVAIEACL
. . .| .  ...||  |. .| .  .....     . .    ...  .|||..||...  ||..| ....|   .||| ||||||.|||||.||.  ..
pglylgslptaldlellkklgi.ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk

qiltD-GkeLDLLGTCRALRNSRAGSIQVDIQYMALVQ
      |  |.|  . . .|. | |... . |.. | .
....klg..lsleealalvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 277-399 1.2e-14 48.5 In-house 88-216 (440) alignment 
Range on Protein: 277-399
Range on HMM: 88-216/440.0
EHILKHLHTKSWPDRCVPNSTMALLRMLYIVR-----TASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALV
 . ||. | ..|||. ||. .  .|.|.  |      ...||. |||||| ||||  .|... |.      ..|..    ..||.|   .|.  ||  . 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QILIN-YGKDNGYWDDSDLDDRVELLTWN
. ...     .    . |. .||| . | 
eavlegllcgdtliledditerveqiqwp
PTPc_DSPc_SM00012 280-375 3.1e-26 87.0 In-house 2-104 (105) alignment 
Range on Protein: 280-375
Range on HMM: 2-104/105.0
LKHLHTKSWPDRCVPNSTMALLRMLYIVRTASG------PVTVHCSAGIGRTGTFVAIEACLQILTDG-KELDLLGTCRALRNSRAGSIQVDIQYMALVQ
.||.| ..||| .||... ..|..|  |..         || ||||||.||||||||.. .|| |... ||.|.. ....||..|.|..| . ||. | .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ILI
.|.
all
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 280-336 7.2e-09 29.8 In-house 217-287 (350) alignment 
Range on Protein: 280-336
Range on HMM: 217-287/350.0
LKHLHTKSWPDR---CVPNSTMALLR-----------MLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQ
. .|. | |.|      |.| .  |             ...    | |. ||||||.|||||.|...  |.
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls
subfamily_PTPDC1_pd Subfamily PTPDC1 286-369 4.7e-07 24.4 In-house 88-167 (182) alignment 
Range on Protein: 286-369
Range on HMM: 88-167/182.0
KSWPDRCVPnSTMALLRMLYIVRTA--SGPVTVHCSAGIGRTGTFVAieaCLQILTdgKELDLLGTCRALRNSRAGSIQVDIQYMA
 .|.|  |. |   .| .  .|  |   | |.||| || ||||  .|   |  . .  |.|.   . . .|. |. |||   |   
fgwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvlia...cylvya..krltaekaiklvrskrpksiqtreqvel
0038934 (Phosphotyrosine protein) phosphatases II 287-330 6.5e-07 24.7 In-house 86-134 (194) alignment 
Range on Protein: 287-330
Range on HMM: 86-134/194.0
SWPDRCVPNSTMALLRMLYIV-----RTASGPVTVHCSAGIGRTGTFVA
 .||.... |.  ||| | .|     . ..| | ||| ||.|||||.||
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_CDC14_pd Subfamily CDC14 290-331 1.3e-07 25.7 In-house 243-283 (328) alignment 
Range on Protein: 290-331
Range on HMM: 243-283/328.0
DRCVPNStMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAI
|  .|.. . . ..| |. .|.| ..||| ||.|||||..| 
DGstPsd.aivkkfleiaekaeGaiavhCkaGLGrtGtLiac
PTPc_motif_SM00404 300-332 9.7e-06 20.5 In-house 69-101 (140) alignment 
Range on Protein: 300-332
Range on HMM: 69-101/140.0
LLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIE
.|...  ...  | | ||| ||. |..|... .
vldfienaekkggkvlVHCqaGvSRSatliiaY
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 302-339 7.4e-08 26.1 In-house 256-293 (349) alignment 
Range on Protein: 302-339
Range on HMM: 256-293/349.0
RMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT
  ||.    . .. |||||| ||||..| ..  |.||.
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_CG42327_pd Subfamily CG42327 308-379 6.2e-12 39.8 In-house 244-316 (319) alignment 
Range on Protein: 308-379
Range on HMM: 244-316/319.0
RTASGPVTVHCSAGIGRTGTFVAIEACLQILTDG-KELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
|   ||..|||| |.||||. .| .  .. | .  . .|.  .   .|. || ...   ||  . ..| .| |
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 313-372 6.2e-08 26.8 In-house 230-289 (297) alignment 
Range on Protein: 313-372
Range on HMM: 230-289/297.0
PVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
.. ||||||.||.|  |  .. |..|  ..  |     . ||. ||  .|   |.  | .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 315-375 1.6e-07 25.6 In-house 2-62 (69) alignment 
Range on Protein: 315-375
Range on HMM: 2-62/69.0
TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
 ||||.| ||||||.||   .  .   | .|..   . .|  |   .  .|.|. .   |.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 316-374 5.6e-07 23.8 In-house 2-60 (69) alignment 
Range on Protein: 316-374
Range on HMM: 2-60/69.0
VHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
||||.| ||||||.||   .  .   | .|..   . .|  |   .  . .|| . . |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal