Gene T23G7.5 in Caenorhabditis elegans

Synonym: CELE_T23G7.5, pir-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP187_AA protein Get Run
CeleP187_AA_33-206 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 3-203 3.4e-21 71.7 In-house 55-302 (307) alignment
Range on Protein: 3-203
Range on HMM: 55-302/307.0
NYHHNHNYQHRPRGYERLPGKRLPD-------------RWNIYDNVGRDIDGTRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAQQANK--------
| . |      |  . |   . |..             |....  ..  . ...|. ...||.... |  .|  |.  ||.....| .   .        
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq..gvtvivmltelvelgrekcaqy

--------QIGLvidltNTDRYYKKTEWADHGVKYLKLNC------------------PGHEVNEREDLVQDFINAVKEFVNDKeNDGKLIGVHCTHGLN
        ..|       | ..........  | .|.. .                  |.| | .  . . |||..|......  ..|. . |||..|..
wPdegeeltygn.....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvg

RTGYLICRYMIDVDN--------YSASDAISMFEYYRGHPMEREHYKKSLYEAERK
|||..|. |.. .          ... .|....   |..  . ... . ||||...
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

subfamily_DSP11_pd Subfamily DSP11 25-205 2e-86 282.4 In-house 1-178 (178) alignment
Range on Protein: 25-205
Range on HMM: 1-178/178.0
LPDRWNIYDNVGRDIDGTRFVPFKTPLDSSFfdGKNMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVnEREDL
.||||. |..||..|.||||..|||||..||  .|....| .|..|.|.. .|..||..|||||||||||||||.|..|.|||||||||||||| ..|.|
vPdrwkkykpvgdkiegtrfiafktPlkesf..dkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeel

VQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERKKK
|..|..|||||........||||||||||.||||||||||.|||..|...|||..||..|||..|||.|.|.|...|..||
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekdkk

0038934 (Phosphotyrosine protein) phosphatases II 25-201 2.3e-49 163.0 In-house 2-173 (194) alignment
Range on Protein: 25-201
Range on HMM: 2-173/194.0
LPDRWNIYDNVGRDIDGtRFVPFKTPLDSSFFDGknMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDL
|||||  |..||. | | ||..||.||..|...   .. ...|....|... .. |...|||||||||.||| ..|. ..|..|||| .|.. .    ..
lPdrwlkyervgdiitg.rfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAE
...|...|.||.  .|. |....|||..||.|||.|...|.| . ..|| .|| .|.  |.. ... .| . |..  
llrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry

subfamily_RNGTT_pd Subfamily RNGTT 26-199 5e-47 154.0 In-house 1-169 (189) alignment
Range on Protein: 26-199
Range on HMM: 1-169/189.0
PDRWNIYDNVGRDIDGtRFVPFKTPLDSSFFdgKNMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLV
|.||      |. |.. .|.|||||| ...   .... | .|  . |.|  .  ....|||||||||.|||.| |  ..|.|| ||.| |. .   .. |
PerWlnCPrkgkliae.kflpfktplskryd..ddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqv

QDFINAVKEFVNdkENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYE
. ||. |.||..  .|  ..|||||||| ||||.||. |.... ..|...|...|   |   . .|.| | |..
kefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellr

0043336 (Phosphotyrosine protein) phosphatases II 36-201 1.1e-21 73.0 In-house 68-273 (278) alignment
Range on Protein: 36-201
Range on HMM: 68-273/278.0
GRDID--------------GTRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAQQAN-----------------------------KQIGLVIDLTNT
| | |              ...|. ...||.... |  .|  ||  ||.|...| .                                ..   |..|. |
ggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel..gvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevt

DRYYKKTewaDHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHP
.......    ... |  |. | |.| |  .|..||..||.|...   .... . |||..|..|||..|. |..     .  .... .|....  .|.. 
nlgdges...rtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpga

MEREHYKKSLYEAE
.. . . . ||||.
vqtpsqyrflyeal

0036282 (Phosphotyrosine protein) phosphatases II 38-202 1.5e-29 98.3 In-house 13-167 (174) alignment
Range on Protein: 38-202
Range on HMM: 13-167/174.0
DIDGTRFVPFKTPLDssffdgkNMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYkkteWADHGVKYLKLNCPGHEVNEREDlVQDFINAVKEFVN
 .  .|.. .. ||.       ...   ..|..|...| .   ......|......|..    . ..|..||.|..|.|.| . .  ...|...|.|...
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsi.llefvkfveeals

DkeNDGKLIGVHCTHGLNRTGYLICRYMIDVDNY-SASDAISMFEYYR---GHPMEREHYKKSLYEAER
.  ..|. . |||..|..|||.|.. |.. .  . |. ||....   |   ..  ..... . ||. |.
e..dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

0040438 (Phosphotyrosine protein) phosphatases II 40-203 1.5e-23 79.0 In-house 70-274 (317) alignment
Range on Protein: 40-203
Range on HMM: 70-274/317.0
D--------------GTRFVPFKTPLDSSFFDGKNMPVELqfgvktlislaqqankQIGLVIDLTNTDRYY-----------------------KKTEWa
|              ...|. ...||.....|  .|  |.                ...... ||... .                        ...|. 
dsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq................gvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.

DHGVKYLKLNC-------------------PGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAIS
..|.....| .                   | | | .  ||..||..||.|. .   ..|. . |||..|..|||..|. |..        .... .|. 
lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavk

MFEYYRGHPMEREHYKKSLYEAERK
..  .|.. .. . . . ||.|...
elreqRpgavqtpeqyrflydalle

0040439 (Phosphotyrosine protein) phosphatases II 40-202 6.1e-22 73.9 In-house 52-243 (249) alignment
Range on Protein: 40-202
Range on HMM: 52-243/249.0
DGTRFVPFKTPLDSSFFDGKNMPVElqfgvktlislaqqanKQIGLVIDLTNTDRY-------------------------------------------Y
 ..||. ...||.... |  .|  |                 .|. ...||.....                                           |
ikrrfiatqgPlpetvedfwrmlwe................lgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnly

KKTEWADHGVKYlkLNCPGHEVNEREDLVQDFINAVKEFVNDKeNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMERE
....   ... |  ...| | | .  . . |||.||......  ..|. . |||..|..|||..|. |..        .... .|....  .|..  . .
dgesrtvlhiqy..tdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

HYKKSLYEAER
.. . ||||..
eqyrflyeall

0045098 (Phosphotyrosine protein) phosphatases II 41-203 1.9e-18 62.3 In-house 63-270 (278) alignment
Range on Protein: 41-203
Range on HMM: 63-270/278.0
GTRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAQ------------------------------QANKQIGLVIDLTNTDRYYKKTEWADHGVKYLK
...|. .  ||.| . |  .|  ||  |......|..                                . .   ...|. |. .......  .||..|.
pkkfIatqgPlpstvadfwrmlwel..gitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

L-NCPGHEVNERE--DLVQDFINAVKEFVN----------DKENDGKLIGVHCTHGLNRTGYLICRYMIDVD---NYSASDAISMFEYYRGH-PMEREHY
. . | |.| . .  . ...... ..|...            ...|. . ||| .|..||| |.. |..      .... .|....  .|..   . .. 
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

KKSLYEAERK
 . |||....
yrflyeflle

0041856 (Phosphotyrosine protein) phosphatases II 42-206 7.3e-24 79.8 In-house 34-172 (182) alignment
Range on Protein: 42-206
Range on HMM: 34-172/182.0
TRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAqqankqiglvidltntDRYYKKTEWADHGVKYLKLNCPGHEVNErEDLVQDFINAVKEfvndken
|||. ...||.|.. |  .|  ||  |..|...|.                ...|  ... ..|..||.|..|.|.| .  | . |||..|.|       
trfiatqgpllstvadflrmlkel..gittivnlt................eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.......

DGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERKKKY
.|. . |||..|..|||.|.. |.. . ..|. .|....  .| .  .....   |. |.. ...
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll

0049772 (Phosphotyrosine protein) phosphatases II 57-206 8.2e-21 70.5 In-house 167-275 (314) alignment
Range on Protein: 57-206
Range on HMM: 167-275/314.0
DgknmpvelqfgvktlislaqqankqiglvidltntDRYYKKTEWADHGVKYLKLNCPGHEVNeREDLVQDFINAVKEFvndkeNDGKLIGVHCTHGLNR
                                    ...| .  . ..|.||| ...|.....  .. ...|.....|.     ..|. . |||..| .|
k...................................eelydpelferlgikylripvpDgsap.lledfdeflefieea.....dkggpvlvHCkaGkgR

TG-YLICRYMIDVDNYSASDAISMFEYYRGhPMEREHYKKSLYEAERKKKY
|| .... |..   ..|. .|....   |     .... ..| . | . ..
tgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilea

PTPc_motif_SM00404 59-203 1.3e-27 91.4 In-house 3-140 (140) alignment
Range on Protein: 59-203
Range on HMM: 3-140/140.0
KNMPVELQFGVKTLIS-LAQQANKQIGLVIDLTNTDRYYkktewaDHGVKYLKLNCPgH-EvnEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNR
...  .|..| |. .. .|......| .||..|.. .        ..  ..  |..| . .  ...| .......|..|... |..|. . |||..|..|
srilphlylgskskaqnpallkklgithvinvteevslt......kensgfqilqip.ldd..nekdklskyldkvldfienaekkggkvlVHCqaGvSR

TGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
...||. |... ...|...|.......| . .........|.| |.|
SatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk

DSPc Dual specificity phosphatase, catalytic domain 66-203 1.5e-31 104.0 Pfam-A 2-133 (133) alignment
Range on Protein: 66-203
Range on HMM: 2-133/133.0
QFGVKTLISLAQQANKQIGLVIDLTNTDRYYkkteWADHGVKYLKLNCPGHEvnEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYM
..| |. .|||......| |||..|.. .      .|..  .. .|..| ..  |.|. .........||... |..|| . |||..|..|...||..|.
ylgskstaslalleklgitlvinvtkevpnn....naikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

IDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
.. .|.|...|.......|.. .........|.|.|||
mktknlslneAyefvkerrskispnagflrqLleyerk

DSPc Dual specificity phosphatase, catalytic domain 66-203 1.5e-31 104.0 In-house 2-133 (133) alignment
Range on Protein: 66-203
Range on HMM: 2-133/133.0
QFGVKTLISLAQQANKQIGLVIDLTNTDRYYkkteWADHGVKYLKLNCPGHEvnEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYM
..| |. .|||......| |||..|.. .      .|..  .. .|..| ..  |.|. .........||... |..|| . |||..|..|...||..|.
ylgskstaslalleklgitlvinvtkevpnn....naikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

IDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
.. .|.|...|.......|.. .........|.|.|||
mktknlslneAyefvkerrskispnagflrqLleyerk

subfamily_PTPDC1_pd Subfamily PTPDC1 68-185 9.7e-10 33.2 In-house 46-156 (182) alignment
Range on Protein: 68-185
Range on HMM: 46-156/182.0
GVKTLISLAQQANKQ-IGLviDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVqDFINAVKEFVndkeNDGkLIGVHCTHGLNRTGYLICRYMI
|.|..| | .. .    |    | ..   |.. .....|. . ..  . ..|.  | .. | .  |.  .    ..|  ..|||  || ||| ||. |..
gikavinLqekgehasCGa..gleesGfsYdlealmeqgiyvynfgwkDygvasleriL.divkvvafal....qeg.kvavhChaGlGrtGvliacylv

DVDNYSASDAISMFEYYRG
 .....|..||..    | 
yakrltaekaiklvrskrp

0048076 (Phosphotyrosine protein) phosphatases II 71-202 8.2e-23 76.1 In-house 18-140 (145) alignment
Range on Protein: 71-202
Range on HMM: 18-140/145.0
TLISLAQQANKQIGLVIDLTNTDRYYKktewaDHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNDkendGKLIGVHCTHGLNRTGYLICRYMIDVDN
| ..|.. .. .|..|..||.. ....     ..|..|| |..|.|.| .  .|...|.....|....    |. . |||..|..|||.|.. |..   .
taldlellkdlgittvlnltselelle.....rlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmlllg

YSASDAISMFEYYRGHPMEREHYKKSLYEAER
.|. .|. ..  .| .  ..... . |||.|.
vsleealelvrsqrpgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 71-202 2.1e-22 74.9 In-house 18-142 (144) alignment
Range on Protein: 71-202
Range on HMM: 18-142/144.0
TLISLAQQANKQIGLVIDLTNTdryYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkenDGKLIGVHCTHGLNRTGYLICRYMIDVDN
|...|.. .. .|..||.||..   | .... ..|..||.|..|.|.| .  .|...|.....|...    .|. . |||..|..|||.|.. |.. . .
taldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklg

YSASDAISMFEYYRGHPMEREHYKKSLYEAER
.|. .|. ..  .| .  . ... . |.| |.
lsleealalvrsrrpgavpnpgqlrfLleyek

0051429 (Phosphotyrosine protein) phosphatases II 71-202 4.8e-14 48.2 In-house 34-222 (272) alignment
Range on Protein: 71-202
Range on HMM: 34-222/272.0
TLISLAQQANKQIGLVIDLTNTDRYYKKT-EWADHGVKYLKLNCPGHEVNERE-----------------------------------------------
|  .... .. .|  ..||.... . .   ..  .|..|| |....... . .                                               
taadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

----DLVQDFINAVKEfvndkendGKLIGVHCTHGLNRTGYLICRYMIDvDNYS--------------ASDAISMFEYYRGHPMEREHYKKSLYEAER
    . . ...... .        |. . |||..| .||| ... ...   . |              . .|...   .| .  . |.  . ||||..
gvpqeallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall

PTEN_1 75-188 5.5e-17 57.2 In-house 60-175 (196) alignment
Range on Protein: 75-188
Range on HMM: 60-175/196.0
LAQQANKQIGLVIDLTNTDRY----YKKTEWADHGVKYLKLNCPGHEVNEReDLVQDFINAVKEFVNDKENdGKLIGVHCTHGLNRTGYLICRYMIDVDN
| ..  . | ||..|.. . .    | ..|. ..||.||..  . | .    . ..|... ..| .  ..| |. . |||..||.|.| ... |..   .
ldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsl.selfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgk

YSASDAISMFEYYRGHPM
..| .|....   | . .
ltadeAlelvrekRppga

0051082 (Phosphotyrosine protein) phosphatases II 76-186 3.5e-18 61.1 In-house 27-134 (151) alignment
Range on Protein: 76-186
Range on HMM: 27-134/151.0
AQQANKQIGLVIDLTNTD-RYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMIDvDNYSAS
.. .. .|  ...|.... |.| .  . ..|...| . .... .   ... . ........ .   .... . |||..|..||| |.. |..   ..|. 
ellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lgvsle

DAISMFEYYRGH
.|....  .|..
ealeeyrlkrpg

0049260 (Phosphotyrosine protein) phosphatases II 77-202 8.3e-21 69.7 In-house 26-147 (152) alignment
Range on Protein: 77-202
Range on HMM: 26-147/152.0
QQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFvndKENDGKLIGVHCTHGLNRTGYLICRYMIDvDNYSASDA
 .  |. |  . .. |...... .. ... .|| |..| | | . ..|..... .....   ....|. . |||..|..||| |.. |..   ..|. .|
wrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleea

ISMFEYYRGHPMEREHYKKSLYEAER
....   | .  . ... . ||| |.
valvrekRpgavpnpgqlrflyefek

0046846 (Phosphotyrosine protein) phosphatases II 77-202 6e-19 63.9 In-house 42-170 (176) alignment
Range on Protein: 77-202
Range on HMM: 42-170/176.0
QQANKQIGLVIDLTNTD-------RYYKKTeWADHGVKYLKLNCPGHEVNEReDLVQDFINAVKEFVNDKendgKLIGVHCTHGLNRTGYLICRYMIDV-
.  . .|..|..||.          .| .  . ..|..|| |. | | | .  .|.........|.....    . . ||| .|..||| |.. |..   
mlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllele

DNYSASDAISMFEYYRG-HPMEREHYKKSLYEAER
 ..|. .|....  .|  .  . ... . |||.|.
kglsveealalvreqRplgavqtpeQyrflyefel

subfamily_DSP12_pd Subfamily DSP12 78-183 1.7e-08 29.0 In-house 23-122 (155) alignment
Range on Protein: 78-183
Range on HMM: 23-122/155.0
QANKQIGLVIDLTNTDRYYKKTEWADHGvkYLKLNCPGhevNEREDLVQDfINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAI
... .|  |. .....    |...      ......     ...||...  .. . .|...  .... . |||. |. |   ..  |..  .. | ..|.
lkelkithvlsvikeelpehklkkgkvs..tkfiqilD...epeediLsh.ldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAl

SMFEYY
.. .  
klvkek

0044763 (Phosphotyrosine protein) phosphatases II 79-204 2.2e-24 81.5 In-house 45-170 (178) alignment
Range on Protein: 79-204
Range on HMM: 45-170/178.0
ANKQIGLVIDLTNTDRYY----KKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSAS
 .  |.....||......     .  . ..|..||....|.| | .  . ...|.....|...   ..|. . |||..|..|.|.|.. |.. . ..|. 
kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglsle

DAISMFEYYRGhPMEREHYKKSLYEAERKK
.||...  .|   ...... . ||| |.. 
eaielvrerRp.ivpnpgqlrqLyefelrl

0043147 (Phosphotyrosine protein) phosphatases II 79-204 3.3e-22 74.5 In-house 41-160 (172) alignment
Range on Protein: 79-204
Range on HMM: 41-160/172.0
ANKQIGLVIDLTntDRYYKKTEWADHGVKYLKLNCPGHEVNeREDLVQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDvDNYSASDAIS
 ...|.....||  ...| ..   ..|..|| |..| | |    .|...|.. ..|..   ...|. . |||..|..|||.|.. |..   ..|. .|..
kelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeava

MFEYYRGHPMEREHYKKSLYEAERKK
..   |..  . ... . ||. |.. 
lvrekRpgavqnpsqyrflyyfekll

0037934 (Phosphotyrosine protein) phosphatases II 79-202 1.8e-21 72.2 In-house 69-239 (243) alignment
Range on Protein: 79-202
Range on HMM: 69-239/243.0
ANKQIGLVIDLTNTD----------------------------------------RYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVND
 . .|. ...||...                                        .... ...  ....|. |. |.| | .  . ..||...|.||...
welgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefiee

-----KENDGKLIGVHCTHGLNRTGYLICRYMIDVD-NYSASDAISMFEYYRGH-PMEREHYKKSLYEAER
     ....|. . |||..|..|||.||. |..    .... .|. ..   |..   . ... . ||||..
llsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

0042113 (Phosphotyrosine protein) phosphatases II 80-202 1.7e-21 72.2 In-house 74-240 (245) alignment
Range on Protein: 80-202
Range on HMM: 74-240/245.0
NKQIGLVIDLTNTDRYYK-----------------------------------------KTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVND
. .|  ...||... . .                                         .. .  ... |. |..|.| | .  .|..||...|......
elgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae

keNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAER
  .... . |||..|..|||..|. |..        ..|. .|. ..  .|..  . ... . ||||..
..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

0039614 (Phosphotyrosine protein) phosphatases II 81-203 4.4e-19 64.5 In-house 124-287 (297) alignment
Range on Protein: 81-203
Range on HMM: 124-287/297.0
KQIGLVIDLTNTDRY--------------------YKKTEWADHGVK-----------------YLKLNCPGHEVNEREDLVQDFINAVKEFVNDKeNDG
 ..  .. ||... .                    . ...  ..|..                 .. .. | | | .  .|...|...|.|...   ..|
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael.pkg

KLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
. . |||..|..|||..|. |..        .... .|....  .|..  . ... . ||.|...
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 81-204 3.8e-11 36.7 In-house 30-147 (148) alignment
Range on Protein: 81-204
Range on HMM: 30-147/148.0
KQIGLViDLTNTDRyYKKTEWADHGVKYLklNCPGHEvNEREDLVQDFiNAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF
|..|.   . |. .  ..  ....|..||  ... .. ...||| . | . . .||. ....|. . ||.. |  |   |   ..|| .. |  .|. . 
kalgvt.rivnatk.erdnaldqrgieYl..hvaldD.kpkedlsaiF.ediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalv

EYYRGHPMEREHYKKSLYEAERKK
.  | .  ..  . | |.| |...
kskrryvdpnlgfLkqLaeleqae

subfamily_CDC14_pd Subfamily CDC14 81-181 1.3e-08 29.1 In-house 211-301 (328) alignment
Range on Protein: 81-181
Range on HMM: 211-301/328.0
KQIGLVIDLTNTdrYYKKTEWADHGVKYLKLNCPGHEVNErEDLVQDFINAVKEFvndkendGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF
...  |. | .    |..... |.|...  |      . . . .|. |......           | |||  || ||| ||  |..   ...|..||. .
nnvttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPs.daivkkfleiaeka.......eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawl

E
 
r

subfamily_DSP10_pd Subfamily DSP10 81-180 1.6e-07 25.3 In-house 38-129 (159) alignment
Range on Protein: 81-180
Range on HMM: 38-129/159.0
KQIGLVIDLTNTDRyykkTEWADHGVKYLKLNCpghEVNEREDLVQDFINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF
 .|  |...|..      .|......|| ...    . .....| | | .|. ||...  . |. . |||  |. |   ..  |..   | | .||  . 
lnitavlnvttsvP....nefeeealkYkripv...sDtskqnlkqyfeeal.efieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfv





subfamily_DSP6_pd Subfamily DSP6 82-179 1.7e-06 21.7 In-house 39-129 (158) alignment
Range on Protein: 82-179
Range on HMM: 39-129/158.0
QIGLVIDLTNT-DRYYKKTEwadhGVKYLKLNCPGHevnEREDLVQDFINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISM
.|  |...|.  .  .....     .|||..    |     ..| . | .|. ||...  .. . . |||  |. |.  ..  |..   ..|  ||  .
kikyvlnvtsnlpnkfeesg....elkylqipiedh...lsqnlakffPeai.efidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydl

0046845 (Phosphotyrosine protein) phosphatases II 88-200 1.1e-13 46.6 In-house 152-269 (284) alignment
Range on Protein: 88-200
Range on HMM: 152-269/284.0
DLTNTDRYYKKTEWADHGvkYLKLNCPGHEVNEREDLVQDFINAVKEFVNDkENDGKLIGVHCTHGLNRTGYLICRYMIDVD--------NYSASDAISM
 |. |.  |.. .   .   .  .. | | | .  . ...|...|.|. ..  ..|. | ||| .|..|||..|. ...           .... .|...
tleltnlgytgesrtvth..fhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkr

FEYYRGHPMEREHYKKSLYEA
.  .| .  . .   . .|||
lreqRpgmvqtleqyrfvyea

0051299 (Phosphotyrosine protein) phosphatases II 88-198 7.6e-12 40.7 In-house 122-279 (288) alignment
Range on Protein: 88-198
Range on HMM: 122-279/288.0
DLTNTDR--------Y-------------------------------------YKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeND
 ||...         |                                     .....   .   .  .| | | | .  .|. ||...|... .   ..
mltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sg

GKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKSLY
|. . ||| .|..||| .|. ...          .. .|. ..  .| .  . .   . .|
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvy

subfamily_PTEN_pd Subfamily PTEN 92-185 5.3e-10 34.6 In-house 69-157 (184) alignment
Range on Protein: 92-185
Range on HMM: 69-157/184.0
TDRYYKKTEWadhGVKYLKLNCPGHEVNeREDLVQDFINAVKEFVNdkENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSAS-DAISMFEYYRG
..|.|....      .  ....  |.   . .|...... ......  |.. ... |||  |  ||| ||. |..    .. . .|...|.  | 
serkydskkf...dgrvavypfdDhnpp.plelleeivediekwle..edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt

subfamily_VSP_pd Subfamily VSP 93-192 6.2e-09 30.1 In-house 84-178 (212) alignment
Range on Protein: 93-192
Range on HMM: 84-178/212.0
DRYYKKTEWaDHGVKylKLNCPGHEVNEREDLVQdFINAVKEFVNDKENdgKLIGVHCTHGLNRTGYLICRYMIDVDNYS-ASDAISMFEYYRGHPMERE
.| | .. . .. ||  ...   |.| . |.|.. | . |||.... ..  ... .||  | .||| ..| ...  . .. | ...  |   | .  | |
eraydekyf.nnrvk..riliddhnvpkleellv.ftkevkewlekdlk..nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktege

H
.
k

subfamily_PRL_pd Subfamily PRL 93-182 1.9e-06 22.0 In-house 43-128 (151) alignment
Range on Protein: 93-182
Range on HMM: 43-128/151.0
DRYYKKTEWADHGVKYLKLNCPGHEVnEREDLVQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDVdNYSASDAISMFEY
.  |....  ..|.. | |.     |   |..|..... .||    ||. .. ..|||  || |.  |..  .|.    .  ||...   
eptydteklekegievldlafddGav.PpeevveeWlellkekf..keepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefire

PTPc_DSPc_SM00012 94-201 5.2e-17 57.3 In-house 3-97 (105) alignment
Range on Protein: 94-201
Range on HMM: 3-97/105.0
RYYKKTEWADHgvkylklN----CpghevnereDLVQDFINAVKEFVNDKENdGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPME
. |. |.| ||       .    .         | . ....|||.. |..|. .| . ||| .| .|||.... ...  .... .. ...|.. .   ..
khyhytgwpdh.......gvPees.........dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkq

REHYKKSLYEAE
|... .....  
Rpgmvqteeqyl

Y_phosphatase Protein-tyrosine phosphatase 94-165 2.9e-06 22.3 Pfam-A 136-192 (235) alignment
Range on Protein: 94-165
Range on HMM: 136-192/235.0
RYYKKTEWADHGvkylklnC--PghevneredlVQ---DFINAVKEFVndkENDGKLIGVHCTHGLNRTGYLICRYM
. .  |.| |||       .             ..   |.|..|..     |.. . . ||| .| .||| ...  .
kqlhytnWpdhg.......vpes..........pkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldi

Y_phosphatase Protein-tyrosine phosphatase 94-165 2.9e-06 22.3 In-house 136-192 (235) alignment
Range on Protein: 94-165
Range on HMM: 136-192/235.0
RYYKKTEWADHGvkylklnC--PghevneredlVQ---DFINAVKEFVndkENDGKLIGVHCTHGLNRTGYLICRYM
. .  |.| |||       .             ..   |.|..|..     |.. . . ||| .| .||| ...  .
kqlhytnWpdhg.......vpes..........pkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldi

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 95-162 5.1e-06 20.7 In-house 156-216 (270) alignment
Range on Protein: 95-162
Range on HMM: 156-216/270.0
YYKKTEWADHGVKYLKlncpGHeVNEREDLVqDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLIC
 .  ..| ||||   .    .. . . ..|.   ..||... ..... . |. |||. |..||| || 
HfwyntWpdhgvpree....ds.slstdqll.kmlravrrsekeldkaePll.vHcsaGvgRtGtlia

subfamily_PTPMT1_pd Subfamily PTPMT1 98-199 2.7e-09 31.7 In-house 66-163 (171) alignment
Range on Protein: 98-199
Range on HMM: 66-163/171.0
KTEWADHGVKYLKLNCPGHE-VNEREDLvqdfINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKS
. ||  .||..|.|. . .    ..|.|     ..| ||...  ..|| . |||  |  |.. |.  |..  .. |  .|... .  | .   ...  | 
teewkklgveqlqlatvDfteapdlekl....ekgv.efiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwka

LYE
|.|
lqe

0047943 (Phosphotyrosine protein) phosphatases II 102-199 3.5e-12 41.8 In-house 165-266 (273) alignment
Range on Protein: 102-199
Range on HMM: 165-266/273.0
ADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNDKENDgKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKS
  .   .. .. | | | .  . . .||..|... .   .. . . ||| .|..||| .|. ...        . .. .|. ..  .| .  . . . . 
srtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf

LYE
|||
lye

0050432 (Phosphotyrosine protein) phosphatases II 107-200 2.3e-12 42.3 In-house 184-294 (308) alignment
Range on Protein: 107-200
Range on HMM: 184-294/308.0
K-----------------YLKLNCPGHEVNEREDLVQDFINAVKEFVndkenDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYR
                  .  .|.| | | .  . . ||...|...      .|. | ||| .|..||| .|. ...        . .. .|. ..  .|
rtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR

GHPMEREHYKKSLYEA
 .  . . . . ||.|
pgmvqtpeqylflyra

subfamily_DSP1_pd Subfamily DSP1 107-184 4.8e-07 24.0 In-house 63-136 (163) alignment
Range on Protein: 107-184
Range on HMM: 63-136/163.0
KYLKLNCpghEVNEREDLVQDFiNAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYR
.| ||.    | ....|. . | . | ||... .. .  . .||  |. |   |.  |..  ...| ..|  .    |
eYkklkl...eDspkadislvf.eeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrR

0036941 (Phosphotyrosine protein) phosphatases II 108-205 2.1e-11 39.1 In-house 173-277 (297) alignment
Range on Protein: 108-205
Range on HMM: 173-277/297.0
YLKLNCPGHEVNEREDLVQDFINAVKEFVnDKENDGKLIGVHCTHGLNRTGYLICRYMI--------DVDNYSASDAISMFEYYRGHPMEREHYKKSLYE
.  .. | | | |  . . |||..|...  .. ..|. . ||| .|..|.| .|. ...           ...  .|. ..  .| .  . .   . |||
fhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye

AERKKK
|. .  
allell

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 108-185 4.2e-06 21.0 In-house 183-257 (319) alignment
Range on Protein: 108-185
Range on HMM: 183-257/319.0
YLKLNCPGHEVNEREDLVQDFINAVKEFVNDKENdgKLIGVHCTHGLNRTGYLICrYMIDVDNYSASDAISMFEYYRG
.  .. | |.| |.  .. |... ... .. ...  . | |||  |  |||  |    . ... .   .. .|.. . 
fqyteWpdhdvPekatslldllkrirksrektqs..gPivvhCsaGvGRtGtfiv.ldamlervkeegvlDvfstvsr

subfamily_PTPRB_pd Subfamily PTPRB 111-181 4.4e-06 20.9 In-house 187-255 (293) alignment
Range on Protein: 111-181
Range on HMM: 187-255/293.0
LNCPGHEVNEREDLVQDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLICRYMIdVDNYSASDAISMFE
.  | |.| |. . . ||...|.| ........ .. |||  |. ||| .|.  .. ... . .| . .| 
tsWpdhgvPektktlldfvrtvreaiektaskrPiv.vhCsaGvGRtGtfialdrl.lqaieeedyvdifg

subfamily_DSP19_pd Subfamily DSP19 120-185 6.8e-07 23.7 In-house 66-131 (152) alignment
Range on Protein: 120-185
Range on HMM: 66-131/152.0
EREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRG
. |  . ...... .|...  .    . |||  |  |.  ..  |..   . | ..|...    | 
lpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp

0048567 (Phosphotyrosine protein) phosphatases II 122-188 4.1e-15 50.5 In-house 53-122 (157) alignment
Range on Protein: 122-188
Range on HMM: 53-122/157.0
EDLVQDFINAVKEFVNDKENDGKLIGVHCTHGL---NRTGYLICRYMIDVDNYSASDAISMFEYYRGHPM
 ... .||. ...| .. |. || | |||..||    ||..||. |.| . ......|| .. ..| . .
lailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv

subfamily_DSP23_pd Subfamily DSP23 125-197 2.9e-09 31.8 In-house 70-138 (148) alignment
Range on Protein: 125-197
Range on HMM: 70-138/148.0
VQDFINAvkefVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSL
|..|..     |.. |. .. ..|||  |  ||| ..  |..   . .|..||.     |   .|    .| .
vvefvrv....veeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklv

subfamily_DSP15_pd Subfamily DSP15 125-187 2.9e-06 21.5 In-house 60-122 (151) alignment
Range on Protein: 125-187
Range on HMM: 60-122/151.0
VQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHP
.. |..   ||. .    .. . |||  |. |   |.  |.. | ...  ||... .. |   
lskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsva