Gene T27A3.5 in Caenorhabditis elegans

Synonym: CELE_T27A3.5, T27A3.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP189_AA protein Get Run
CeleP189_AA_57-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 55-327 5.1e-63 207.5 In-house 7-287 (305) alignment 
Range on Protein: 55-327
Range on HMM: 7-287/305.0
NEPILRDFVKATIQTGVKQLSTEFLNLKMETQPCNK-----PKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEdsPSDYIHANWVKIN--GANKFICTQGP
  ||. .||. ... ||..|  || .|   |.|         .   .    ||||.|| | | . | |. |   ||||||||.|       ..|||.|||
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgp

TEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdGQMILMDGKLTVKIAEPAKEVEQ----NILLMKITVidDKGTSHNFEHWQWKAWPDR
 ..|.|.|. .. |.|   .||||. .| || || |||| .  |.   . . . |.    .| .|.    .| |...|     . .    | ||  ||||
ldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq.geklelksgivvenvsgskpmerdaeiqitllnlty..sgdqkmsvrhlqwtewpdr

GVPELPMAVFRLLIRLKTA-SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKV-VLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
|||   .. . ||  .. .  ||||||||||||||.|| .|  | | .   ..  . ..|| .|.||  |.|.| ||||.|||.| 
gvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmln
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 58-339 1.9e-75 248.7 In-house 2-288 (307) alignment 
Range on Protein: 58-339
Range on HMM: 2-288/307.0
ILRDFVKATIQTGVKQLSTEFLNLKmETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDSpSDYIHANWVKING-ANKFICTQGPTEKTVDDFY
... .|. |.. ||..|  || .|  . .|   .    .  ..||||.|| |.| .|.|.| .  . |||||||.. |    .||||.||| |.|. .|.
vvkpwvqrtldkgvqalvdefrvla.kktpegvtveafsantdknryqdvkcqdkgrivvkfdgla.sdyihanylgiaikpkkficaqgplentqysfw

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEP-AKEVEQNILLMKITV--IDDKGTSHNFEHWQWKAWPDRGVPELPMAVF
 .. |||  .|.|||...| .| |||||||     ...  .   |. .|.  ||..  .  |...|   .|  . |   .|.||. |||||||.. ..  
amaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltai

RLLIRLKT-ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKV-VLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL-AENRKITSPEL
 ||   .    |.|||||||.||.|.||.. .   |  ||.    .|..|.|.|.||| ..||.||||..|||||    |  | |  ||
nlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeel
0039614 (Phosphotyrosine protein) phosphatases II 58-328 8e-73 240.8 In-house 18-288 (297) alignment 
Range on Protein: 58-328
Range on HMM: 18-288/297.0
ILRDFVKATIQTGVKQLSTEFLNLKMETQPcnKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED--SPSDYIHANWVKING--ANKFICTQGPTEKTVD
.|  ... . ...  .| .|| .|.  . .  .  . .. . .||||||... |..||.|| ...   .||||.|..|.      .|||.||||...||.
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetve

DFYRLIWQEKAPCVVMLCNIMECGKkKCEQYWPETADgqmilMDGKLTVKIAEPAKevEQNILLMKITVIDdKGTSHNFEHWQWKAWPDRGVPELPMAVF
||.|..|... ...|||.. .|.|. ||.|||||. .     . |..||.  .  .  .... . ...| . .| |.   |.|.  ||| |||...  ..
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdftvtllkveh..ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslelll

RLLIRLK-------TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
..|  ..          |..||||||.||||..... ..|  .  . .| ....|||.|.||.|.|||. || | ...|| |
eflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 58-331 7.2e-70 229.9 In-house 13-285 (290) alignment 
Range on Protein: 58-331
Range on HMM: 13-285/290.0
ILRDFVKATIQTGVKQLSTEFLNLKMET---QPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKwpEDSPSDYIHANWVKINGaNKFICTQGPTEKTVDD
 .  |   ... .|..|. |.|.  .     |. ..    .. . .||||||| | | |||.||  .  . ||.|||.||      || |||....|| |
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dGydGdyvhanyvkGlk.amfiltqGalkdtvid

FYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdGQMiLMDGKLTVKIAEPAkEVEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVF
..|.. |||.  .||||...| || |||||.||.. |.. |  |..||  .|   . ..|| .  ..| | |.| .| . |.. |.|||. |.   .|..
iwrmvlqekvaaivmlceliedGkakceqyypeke.Gev.ltfGeitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

RLLIRLKTAS-PIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
|.|  |..|| |.||||||||||||..| .|..|  .  | .. | |.|. .|| | .||| | ||| . ..|| |  .
rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 58-328 4.2e-49 162.1 In-house 5-270 (288) alignment 
Range on Protein: 58-328
Range on HMM: 5-270/288.0
ILRDFVKATIQTGVKQLSTEFLNLKMETqpCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVKINGA-NKFICTQGPTEKTVDDFY
..  ...  .| .|. |  |. .   |.   ..  . . . | ..||..... | ||| |.   | |  ||.|| |  .   ...||.| | . |.. ..
vinawirlvlqiaveglkkeyrdspnea..sidiidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelW

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdGQMILMdGKLTVKIAEPAKEVEQnILLMKITVIDDKGTSHN-FEHWQWKAWPDRGVPELPMAVFRL
... ..    .||||...| ||.| ..|.|    |. . . |.|   . .  ..... .. . .  |  .|  .    .  .. |.| ||||  .. .||
kmllesdveyivmlcellekGkeksaeyfPskl.Gekari.grlctvvkkkradidk.lvkvsllriskegeekvivkilhlleWdddgvPenylsplrl

LIRLKT-ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
| .||.   |||||.|||.|||| ..   |||.  .  . . .. .... |..|  ..||  |||..||..|  
levlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
0051299 (Phosphotyrosine protein) phosphatases II 59-327 7.9e-77 253.8 In-house 10-284 (288) alignment 
Range on Protein: 59-327
Range on HMM: 10-284/288.0
LRDFVKATIQTGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED-SPSDYIHANWVKI-NGANKFICTQGPTEKTVDDFY
|...|......|...|  ||  |   . ...   . .. . |||||.|... |..||.|..... ..||||.|..... |  .|||.||||...||.||.
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPEtadgQMILMDGKLTVKIAEPAKevEQNILLMKITVID-----DKGTSHNFEHWQWKAWPDRGVPELPMA
|..|... ...|||....| |..||.||||.    .  |. |..||.. .  .  .... . ...| .      .|.|..  |.....||| |||. | .
rmvweqnvrvIvmltklvelgrekcaqYwpl....ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

VFRLLIRLKT-----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
....| ....      .|.|||||||.|||| .. |...|  . ....| . ..|| .|.||.|.|||  ||.| ...|| 
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
subfamily_PTPRD_pd Subfamily PTPRD 59-330 3.7e-67 222.2 In-house 10-282 (564) alignment 
Range on Protein: 59-330
Range on HMM: 10-282/564.0
LRDFVKATIQTGVKQLSTEFLNLKMEtQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVL-KWPEDSPSDYIHANWVKI-NGANKFICTQGPTEKTVDDFY
|...|.   ...  ....|. ..... |  .. .  ..   .||||...   | .|||| | . |. |||| |....  .  ...| ||||...|..|| 
lkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPETaDgQM-IlmdGKLTVKIAEPAKEVEQNILLMKItVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRL
|..|...  ..||| .. | ||.||..||||. . .  .   |.|||.. |  .  .  |  .|.    ..  |.. ..... .|||.|||| . .. .|
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety...geltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdl

LIRLKT-----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAE
. . ..     | |||||||||.||||  . ... | .  . ..| .  .||..|.||   |||  || |.|...|   .
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 59-331 2.9e-59 195.7 In-house 10-285 (319) alignment 
Range on Protein: 59-331
Range on HMM: 10-285/319.0
LRDFVKATIQTGVKQLSTEFLNLKMETQPcNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFY
|.. .||  .|| ..|  || .||. ..  .  .. .|   .||||...  .| |||||.  ..   |||| |...   .  .||| ||.| |.|..||.
Lkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfW

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdgqmILMDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLL
|..|.|.. .||||... | .| |...||||.     .   |.|.|.. |  .  .  |  .|.    ..  . .  |.|...||| .|||  ...  ||
rmvWeeessivvmltklveklkvklkkywpeen....feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldll

IRLKT------ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
 |..       . |||||||||.||||. . |...| .    . . .  .|...| ||   ||. .|| |.. .||. .| 
krirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 59-328 1.7e-56 186.6 In-house 7-279 (318) alignment 
Range on Protein: 59-328
Range on HMM: 7-279/318.0
LRDFVKATIQTGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED-SPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFY
|.. |.   ..|  .||.|. .|. ...   . |. ..    |||| ..   |.||| |.  |.   |||| ||..  .   ...| .|.|  .|..||.
leshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfW

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMilmdGKLTVKIAEPAKEVEQNILLMKITViDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLL
|..|. ..  .||| ...| ||.|...|||.    ..    |||.|.. |  .  .  .  .|.|  ...  | .   ... .|||.|||| .. .  |.
rmvWeqnsavivmltqeeergkakvhryWPskgsrsy....gklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlv

IRLKTAS------PIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
 . ..|       |||||||||.||||  . ..| | .  | . | . ..||..|.||   |||. || |.. |||  
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 59-333 6.8e-51 167.7 In-house 14-294 (310) alignment 
Range on Protein: 59-333
Range on HMM: 14-294/310.0
LRDFVKATIQTGVKQLSTEFLNLKMETQPCNKpKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDSPSDYIHANWVKING-ANKFICTQGPTEKTVDDFYR
| .|. || . |.. |  .. .|  . ..       .. .  |||| || | |..|| ||       ||||||.|| |   . |||.||| ..|. ||.|
lenfiiateklgieglvkqyrkldakqdsslt.yeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwr

LIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMilMDGKLTVKIAEPAKEVEQNILlmKITVIDDKG----TSHNF-----EHWQWKAWPDRGVPEL
.|.||.|  ...||...| |. ||  |||     .          ...| ..| |   |   .| . |.        |.     .  .|  |||||||. 
mifqeraesilllckvgeegrpkcvgywpslgvtet..ygcirvtnlsesseefeicnl..avtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde

P-MAV-FRLLIRLKtASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRK
   .|  ||| ...   | |||||||..|.. .| |.... |   |.|| ..... |....|   .||. |||...|| ...|   .
kchtvpqrllaqvr.hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifarget
subfamily_PTPRA_pd Subfamily PTPRA 60-327 5.1e-53 175.1 In-house 20-293 (330) alignment 
Range on Protein: 60-327
Range on HMM: 20-293/330.0
RDFVKATIQTGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVK-INGANKFICTQGPTEKTVDDFYR
 . ..  .    |..  || .|   .  .    . .|   ||||. ..   | .||.|   |  . |||| | ...  .  .||| .||| |.||.||.|
eeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwr

LIWQEKAPCVVMLCNIMECGKKKCEQYWPEtaDGqmILMDGKLTVKIAEPAKEVEQNILLMKITVIDDKG---TSHNFEHWQWKAWPDRGVPELPMAVFR
.||. |.  .||| .. |  ..||.||||.  .|  ..  |...|.. .    |.  .  . .. . |.    .|   . . ...||| |||  |. ...
miweqksativmltelkerkeekcaqywPd..eG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlk

LLIRLKT-----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
|| ..|.     |.|||||||||.||||. . |.  | .  | .|| . ..||..|.||   |||| || |...||| 
llkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
0040438 (Phosphotyrosine protein) phosphatases II 61-350 7.7e-78 257.3 In-house 7-296 (317) alignment 
Range on Protein: 61-350
Range on HMM: 7-296/317.0
DFVKATIQTGVKQLSTEFLNLKMETQPcNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPE-DSPSDYIHANWVKING-ANKFICTQGPTEKTVDDFYRL
....  .. ....|. || .|   . . .   . .. ...||||.|... |..||.|. .. | .||||.|..|..    .|||.||||...||.||.|.
lalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

IWQEKAPCVVMLCNIMECGKKKCEQYWPEtaDGQMILmdGKLTVKIAEPAKevEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLI
.|...  ..|||.. .|.|..||.||||.  .. .    |..||.. .  .  ...| | ...| | ....|.   |.....||| |||. |  ....| 
vweqgvtvivmLteleelgrekcaqYwpl..getlty..gdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

RLKT-----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAeNRKITSPELSAFVAEYDKVI
....      .|..||||||.||||........|  .  ...| ....|||.|.||.|.||| .|| |....|| .  .||.|....| .. ...|  
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.krkltlepaselklkllkll
0045450 (Phosphotyrosine protein) phosphatases II 61-328 8.7e-73 241.0 In-house 16-303 (307) alignment 
Range on Protein: 61-328
Range on HMM: 16-303/307.0
DFVKATIQTGVKQLSTEFLNLKMETQ--PCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED--SPSDYIHANWVKIN---------GANKFICTQGP
 .|. ......  |  ||  |. .|   ...   . .. . .||||||... |.|||.|. ...  ..||||.|..|...           .|||.||||
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

TEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETaDGQMILmdGKLTVKIAEPAKevEQNILLMKITVID--DKGTSHNFEHWQWKAWPDRGV
...||.||.|..|...  ..|||.. .|.|..|| ||||.. ....    |..||.  .  .  .... .....| |   .| |.   |.....||| ||
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geelty..gnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

PELPMAVFRLLIRLK-------TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEK---VVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
|. .  ..... ...         .|..||||||.||||..... ..|. . ....   | | ..||..|.||.|.||.  || | ...|| |
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 61-339 5.1e-67 220.8 In-house 11-297 (305) alignment 
Range on Protein: 61-339
Range on HMM: 11-297/305.0
DFVKATIQTGVKQLSTEFLNLKMEtQPCNKPKTGHEG-HPEKNRYKDVYCIDDTRVVLKWPedSPSDYIHANWVKING-ANKFICTQGPTEKTVDDFYRL
.||| |.. | . | .|| ..|   .  .| |. .|  . .||||||| |.|. || |. |   | .|||||.|     ...||||| | |||  ||. .
kfvkrtlekgpaglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvklegp..wpheyihanyvstptnpkrfictqaplektcadfwym

IWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILM--DGKLTVKIAEPA-----KEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMA
 .|.|   . ||||..| | ||| .|..   . .. .   . |..||.   .     |. . ..   ....    ....   |. |  |||||||   .|
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadla

VFRLLIRLKT-ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLK-DIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKITSPEL
.. ||.. ..   |||||||||||||||.| ||  | .. ||...     |.. ||.||  |.||||||||.|.|.|   ...|.   | 
ilellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeev
subfamily_PTPRB_pd Subfamily PTPRB 61-333 1.6e-61 203.0 In-house 14-289 (293) alignment 
Range on Protein: 61-333
Range on HMM: 14-289/293.0
DFVKATIQTGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVL-KWPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRL
..|| . .    ..| |. .||   .  .. .. ..   .||||...   | .|| | .  ..| |||| ||...  |  ..|| ||||  .|||||.|.
ehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrm

IWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQmilMDGKLTVKIAEPAKevEQNILLMKItVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR
.|..|.  .||| ...| ||.|||.|||.. . .   . |...|.. .  .   ..  . ..  |  . .... .......||| |||| . .. ... .
vwekkssiivmltqlvekgkvkCeeYWPadeepv...lyGdikvtlvaeee..ledwvirel.kiekekeerkvrqyhftsWpdhgvPektktlldfvrt

LKTA-------SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRK
...|       .|||||||||.||||  . |.  | .    . | .  || |.|..|   ||| .||.|.|...|.| ....
vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 61-330 1.1e-50 167.1 In-house 9-284 (290) alignment 
Range on Protein: 61-330
Range on HMM: 9-284/290.0
DFVKATIQTGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLK---WPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFY
.||    ..| ..  ..|  |.   .. .      .   ..||....   || |..|.     .| . .||.| ..|  . ....| ||||...|. ||.
efvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFW

RLIWQEKAPCVVMLCNIMECGKKKCEQYWPETaDGQMiLmdGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRG-VPEL--PMAVF
.|||||| ...|||.||.| ||.|| ||||.. | .. .  |. ..|. .  .  |  .  ....  . .|....  ..| ..|.. | |..    . |.
kliwqekvtiivmltniieegkvkCqqYWpds.dtka.y..gefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

RLLIR---LKTASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAE
.  ..    ..  .||||||...||..  . ..... |      . . ...|. | |. |||||  || ......|   .
eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPN9_pd Subfamily PTPN9 61-257 1.6e-43 143.9 In-house 5-200 (297) alignment 
Range on Protein: 61-257
Range on HMM: 5-200/297.0
DFVKATIQTGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLK-WPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRL
..|.   ..| . || |..... |.   .  .. . .  |||||.|| |.|.|||||.  .||. ||||.||.|   .  . || |||| .|||.||.|.
elvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrm

IWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMilMDGKLTVKIAEPAKEVEQNILLMKITVIDdKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLI
.|....  .||   ..| |. || ||||.. . ..    |.|.|.  |  .| . ..  ..|. .. .. | .  |.|  .||| |||.  .... .| 
vWeqevlvivmttrvvergrlkcgqyWpleeessa..efgdlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvle
0043336 (Phosphotyrosine protein) phosphatases II 62-326 2.6e-69 229.1 In-house 10-274 (278) alignment 
Range on Protein: 62-326
Range on HMM: 10-274/278.0
FVKATIQTGVKQLSTEFLNLKMETQpCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVKING-ANKFICTQGPTEKTVDDFYRLI
...    .. . |. || .|   .  ...  . .. . .||||||... | .||.|.  ..| .||||.|..|.     .|||.||||...||.||.|..
allelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmv

WQEKAPCVVMLCNIMECGKKKCEQYWPetadgQMILMDGKLTVKIAEPAKevEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR
|... ...|||.. .| |..|| ||||     .  |  |..||.  .  .  .... . ...| .  .| |.   |.....||| |||| .  ....| .
welgvttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

LKT-----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
...      .|..||||||.|||| ...|...|  .  . .| | ..|||.|.||.|.|||. || | ...||
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 62-338 5.3e-58 191.6 In-house 12-294 (305) alignment 
Range on Protein: 62-338
Range on HMM: 12-294/305.0
FVKATIQTGVKQLSTEFLNLKMETQPCNKPKTghEGHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLI
..| .  .  |.| ... .| .| ....  |.  | . .|||.|..   || |. |.  |. . |||| |..|.  .. .|.| .||| ..||.||.|||
yikearvysdkgleaqykslyeeeesidvgkk..eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrli

WQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILmdGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRL
..||   .|||....| ||.||.|||||.   .. .  |...|.. . ..  .  .  .||.. |..  |..  ..|   ||| |||. . .. .|. |.
veekvstivmltklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

K---TAS---PIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRK--ITSPE
.     .   |..||||||.||||  . ..||| .  . | | . ...|..|..| . ||| .|| |.| .|  | .  .  |    
qkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsn
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 62-330 1.7e-43 143.7 In-house 10-279 (287) alignment 
Range on Protein: 62-330
Range on HMM: 10-279/287.0
FVKATIQTGVKQLSTEFLNLKM-ETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVKI-NGANKFICTQGPTEKTVDDFYRLI
||.   ..| .. .. |  |.  . .. .   .  .   .|||....   |. ||.||   .   ||| | ...  . ...|| ...|  .|. .|..||
fvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkli

WQEKAPCVVMLCNIMECGKKKCEQYWPETADgqmiLMDGKLTVKIAEPAkeVEQNILLMKITVIDD--KGTSHNFEHWQWKAWPDRG-VPELPMAVFRLL
.... . .||||. .|  ...| |||||..     .. |. .... .    |... .  |. |. .  .|. .. . .|  .|...| |.|    .. . 
ddrnvtaivmlcqekendeevcyqyWpeeks....vvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

IRL-----KTASPIVVHCSAGIGRTGSIVGLEIALVKfCAGEKV-VLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAE
 .      .. ..||||||...||..  .  .... | |  | |  . ...|. | |. ||||| .|| |.  ..|.  .
emyktqrkrgntsivvhCsdtvGrsamfcaaattink.ckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 64-327 8.7e-55 181.0 In-house 19-288 (298) alignment 
Range on Protein: 64-327
Range on HMM: 19-288/298.0
KATIQTGVKQLSTEFLNLKMETQ--PCNKPKTGHE-GHPEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRL
. . .... ....|| .|.  ..  . .. . ...    .|||| |.  .| .||||.   .|  |||| | ...  .| | || ||.| ..|| ||.|.
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrm

IWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMilmdGKLTVKIAEPAKEVEQNILLMKITVIDDKgTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR
...|.. ..||| |. | .| |...|||..   .     |..||.. .  .  .  .  .|..  . . ....  . ..  |||.||||   .|. || .
vteedigtiVmltnleeldktkyhkywPdegkety....geitvsllskeefadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrk

LKT----A--SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
 ..    |  .|..|.||||.||.|. . ..  | .  . ..| . ..|| .|..| |.||| .|| |.. . | 
vrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_PTPN6_pd Subfamily PTPN6 66-333 8.7e-57 187.4 In-house 20-301 (306) alignment 
Range on Protein: 66-333
Range on HMM: 20-301/306.0
TIQTGVKQLSTEFLNLK-ME-TQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDSPSDYIHANWVK---INGANKFICTQGPTEKTVDDFYRLIW
. ... . .. || .|. .| ..  .. .. .    |||||| .   |.|||.|| |. . |||| || .|    .  ...| |||  |.|| ||.|..|
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

QEKAPCVVMLCNIMECGKKKCEQYWPETADGQMilmDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLK
||..  .||. . .| ||.|| .|||.. . ..    ||..|.  .  .  . ..  .... ...|.....  ....|.||| |||. | ||  .|  ..
qensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

---------TASPIVVHCSAGIGRTGSIVGLEIALVKFCA---GEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRK
         .| ||||||||||||||... ..| | .        .. ....|| .|.|| | |||..|| |..... .  |..|
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 66-328 7.6e-55 181.0 In-house 9-275 (281) alignment 
Range on Protein: 66-328
Range on HMM: 9-275/281.0
TIQTGVKQLSTEFLNLKM-ETQPCNKpKTGHEGHPEKNRYKDVYCIDDTRVVL-KWPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQE
. |   . . .|. .|.  ...   .  . ..   .||||...   | |||.. .  |.. .||| ||.|. ..| ...| ||||  .....|....|..
lsqndnaGfieeyeklaaigvdntat.askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweq

KAPCVVMLCNIMECGKKKCEQYWPETADgqmILMDGKLTVKIAepAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAV--FRLLI---
|.  .||. . .| || || .|||. .     |  |..|||    |.| ... .  |...  ..| . . |. ...|||| |||. ....  ||  .   
kvsaivmvtreieagklkChrYWPddns...elkygdvtvkst..aeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

-RLKTASPIVVHCSAGIGRTGSIVGLEIALVKFCAG-EKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
 . ||  |.|.|||||.||||. ..|. .. .  |  |.. .|..|.|.|..|   ||| .|| |.....|  
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 66-345 1.2e-45 151.2 In-house 28-309 (319) alignment 
Range on Protein: 66-345
Range on HMM: 28-309/319.0
TIQTGVKQLSTEFLNLK-METQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPE-DSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQE
 ..  ...|  || ..  . .. ...  .  .   .|||. ..   | ..| |.  .    |||| | .|.     .|.| .||| . |..||.|.||. 
dfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

KAPCVVMLCnimecgKKKCEQYWPETADGQmilmDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR----
..  .|.|       |.|| ||||  .. .    ...  ||.    .  |  .  ....    .    .   . .. ||| |||. |. ..||. .    
ncstivllt......kdkcsqywplkivik....eerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhl

---LKTASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA--LAENRKITSPELSAFVAE
    .   .||||||||.||||  . |.. | ..   ..| . ..|...|.||   ||  .|| |..  ||   |  .  .. |.. |.. |
tskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpaylee
subfamily_PTPN23_pd Subfamily PTPN23 67-331 8.6e-49 160.9 In-house 10-282 (288) alignment 
Range on Protein: 67-331
Range on HMM: 10-282/288.0
IQTGVKQLSTEFLNLKMETQPCNKP--KTGHEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVK--INGANKFICTQGPTEKTVDDFYRLIWQE
   |. .| ..| .|... .  ..    .  . ..||||..|.   | .||.|.   .|  ||| | .||    |. .||.||.| ..|. ||.......
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

KAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPAKEVEQNILlmKITVIdDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-
|.. .||| .  | ||.|...||||  .  .   | ..|.|  . .... . .|  |...  |. . ..  | |...||. |||. |  ....|   .. 
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervl..kletl.dadavksvshlqltsWpelGvPasPetllqfldevesa

--------ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVV-LKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
          |.|||||||.|||| .  .  |. .. .|. .. . ..|. .|.||. .||. .|. |.  . |  |..
yeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
0050432 (Phosphotyrosine protein) phosphatases II 69-332 1.1e-77 256.7 In-house 39-302 (308) alignment 
Range on Protein: 69-332
Range on HMM: 39-302/308.0
TGVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLkwpeDSPSDYIHANWVKI---NGANKFICTQGPTEKTVDDFYRLIWQEKAP
.. ..|..||  | . . ...   . .. . .||||||... | .||.|    |..||||.|..|..   .  .|||.||||...||.||.|..|... .
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvr

CVVMLCNIMECGKKKCEQYWPETAD-GQMILmdGKLTVKIAEPAKevEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-
..|||....| |..||.||||.. . | ..   ||.||.. .  .  .... . .... . ..| |.   |.....||| |||. | .....| ....  
vIvmLtklvengrekcaqYwplelgggsley..gkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl

--SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENR
  .|||||||||.|||| .. |...|  . .. .| . ..|| .| ||.|.|||  ||||..|.|| .....
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 69-334 4.4e-60 198.2 In-house 18-284 (288) alignment 
Range on Protein: 69-334
Range on HMM: 18-284/288.0
TGVKQLSTEFLNL-KMETQPCNKpKTGHEGHPEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAP
.. ...| |. .| ..| .  .. .. .    .||||...  .| .|| ||  .| . .||| |.... . . .|.|.||||  .||.||..|....|. 
rnrtgfseeynsLaalektksvt.agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

CVVMLCNIMECGKKKCEQYWPETADGQMIlmdGKLTVKIAEpAKEVEQNIlLMKITVIdDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA---
 .||| ...| ||.|||.|||.. . .     |..||.. |  ||.|. . | |. .   |.|  .  ..|..|||| ||||  . .. ||  .|.|   
tivmltelveggktkCeeYWPdadkpkny...Gsvtvtlve.skeledfv.lrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

--SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKI
   ||.||||||.||||  . |. .. .  . ... . ..|...|.||   |||  || |...||| |.|.. .
dtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_PTPRG_pd Subfamily PTPRG 69-330 3.5e-52 172.4 In-house 16-288 (563) alignment 
Range on Protein: 69-330
Range on HMM: 16-288/563.0
TGVKQLSTEFLNLKMETQPC--NKPKTGHEGHPEKNRYKDVYCIDDTRVVLKW-PEDSP-SDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEK
 | . .| || .|..||..   .  .. ..   .|||| ..  .| .|| |.  |.     ||| ||...  . ...|| |||| ..|.|||.|.||...
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

APCVVMLCNIMECGKKKCEQYWPEtaDGQMILmdGKLTVKIAEPAKEVE---QNILLMK--ITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR
.  .||. |. | |..||..|||.  |. . .  |.|.|.. |  . .    ... . .  .   ... | ..  ....  ||| |||| .. |    ..
vaiivmitnlvergrrkcdvYWPk..desety..galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkk

LK-----TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAE
 .     .| |||||||||.||||  . |.  | .  . ..| . ...| || ||   |||  ||.|.| .|| .  
ssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
0047943 (Phosphotyrosine protein) phosphatases II 70-327 2.6e-73 242.1 In-house 10-270 (273) alignment 
Range on Protein: 70-327
Range on HMM: 10-270/273.0
GVKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLkwpEDSPSDYIHANWVKI-NGANKFICTQGPTEKTVDDFYRLIWQEKAPCVV
|...|  ||  |.  . ....  . .. . .||||||... |..||.|   .|..||||.|..|.  |  .|||.||||...||.||.|..|.......|
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLCNIMECGKKKCEQYWPETADGqMILMDGKLTVKIAEPAKevEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT------
||....| |..||.||||.. .. . |. ||.||.. .  .  .... . .... . . | |.   |.... ||| |||. .  .....  ...      
mLtelvelgrekcaqYwplegge.lsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

-ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
  .|.|||||||.||||... |...|  . .. .| ....|| .|.||.|.|||  ||.|....|| 
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 71-328 2.7e-56 185.7 In-house 4-267 (274) alignment 
Range on Protein: 71-328
Range on HMM: 4-267/274.0
VKQLSTEFLNLKMETqPCNKPKtgHEGHPEKNRYKDVYCIDDTRVVL--KWPEDSPSDYIHANWVKINGA--NKFICTQGPTEKTVDDFYRLIWQEKAPC
.|.| .|||.| ..  . ....    |. .|||||..   . .||.|  . .||. |.|| ||..|  .   . .. ||||  .||.||.|.|.||... 
fkdlekeflelPlnf.dqeeld..vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqv

VVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPAKEVEQNIllmKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-----
.||| .. |  ..||..|.|.. | ..    |.. .|. .  .. . ..   .  |.     ...  |. . .|||. .|. . ....|.   ..     
ivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysv...rklvlkylerersvkhywytdWPdhksPddantlldlvleveesreee

---ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
   ..|.||||||||||||  .. .||. .. . ..| .  || ..| .| | |||. || ..||.|   
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 71-326 6e-42 138.4 In-house 14-290 (301) alignment 
Range on Protein: 71-326
Range on HMM: 14-290/301.0
VKQLSTEFLNLKMETQPCNKPKTgHEGHPEKNRYKDVYCIDDTRVVLKWPED---SPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPC
 .... .. .|| ...  .. .. .| . . ||.|..  .|| |..||  ..   .  .|| |.... .. ..||| .||| .||. ||.|||||||   
snkfeeqykelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs

VVMLCNIMECGKKKCEQYWPETADGQMILmdGKLTVKIAEPA--------------KEVEQNILLM-KITVIDDKgTSHNFEHWQWKAWPDRGV---PEL
.||..|  |. |.|||||||..   .     |..||.. . .              ... .|  .. |. |  || .|..   .|   ||. ||   |  
ivmvtnlkegtkskceqywpnseaeseef..gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprt

PMAVFRLLIRLK---TASPIVVHCSAGIGRTGSIVGLEIALVKfCAGEKVV-LKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
 . |    |  .     .|.|||||....|.|  . ..|.|   |  | || . ...| .| .. | |.|  || ... |. 
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ.ckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_ptpA1_pd Subfamily ptpA1 71-286 1.7e-32 107.7 In-house 20-253 (418) alignment 
Range on Protein: 71-286
Range on HMM: 20-253/418.0
VKQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED-SPSDYIHANWVKINGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVM
....  ||  |.    | .  .  ..    |||| ..  .. ||| ||  .|   |||| ||..     ..|||||||  .|. ||.|..|....  .||
ihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivm

LCNIMECGKKKCEQYWPETADGQMILMD-------GKLTVKIAEPAKEVEQNILLMKITVIDdKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRL---
|    |  . ||..||||   |. . .        |  .|.. |  .. |..|.  .| .   .| ...  ..|.. |||. .|.    . .||  .   
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrditqyqyegwpdhnipdhtqpfrqllhsitnr

--------KTASPIVVHCSAGIGRTGSIVGLEIAL
            ||.||||||.||||...   | .
qnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 71-339 3.3e-23 76.6 In-house 28-294 (302) alignment 
Range on Protein: 71-339
Range on HMM: 28-294/302.0
VKQLSTEFLNLKMETQPCNKpktgHEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVKING-ANKFICTQGPTEKTV---DDFYRLIWQEKAPC
||.   .  ..|.... |.     .  ...||. .|| ..|...| |.    .| .|..|  |..    .. | .| |. ...   ..|.|...|||   
vkkefkkidtmkvdlekCka....fkknlkknqsedvpildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVMLCNIMECGKkKCEQYWPETADGqmILMDGKLTVKIAEPAKEVEQNiLLMKITVI-DDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRL-----K
||.|    |. |   ....|....    .  ||. | .    | .|..     | |. ..   |   .    . |..  ||.   .. .    .     |
vvilvgeeelkk.tlselfpkksgd..ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkik

TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENrKITSPEL
. ...|.    |.|| |... | .|. |  .|...  |.||| ||.||  .|..  || .....|| .  . |.|.|| 
adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk.kvtkpee
0036941 (Phosphotyrosine protein) phosphatases II 72-337 5e-76 251.2 In-house 13-285 (297) alignment 
Range on Protein: 72-337
Range on HMM: 13-285/297.0
KQLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLkwpEDSPSDYIHANWVKING-ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVML
 .|..||  |     ....  .  ... |||||||... |.|||.|   .|..||||.|..|.. .  .|||.||||...||.||.|..|... ...|||
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

CNIMECGKKKCEQYWPETADGQMILmdGKLTVKIAEPAKEVEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-------A
.. .| |..||.||||.. .. .    |..||.  .  .  .... | ...| | ..| |.   |.... ||| |||| |  ..... ....        
telvelgrekcaqywpleegeslty..gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

SPIVVHCSAGIGRTGSIVGLEIALVKFC---AGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKITSP
.|..||||||.||.|........|  ..     ..| ....||..|.||.|.|||  ||.|....|| |  ....  |
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_PTPN12_pd Subfamily PTPN12 72-331 2.9e-62 205.2 In-house 8-279 (290) alignment 
Range on Protein: 72-331
Range on HMM: 8-279/290.0
KQLSTEFLNLKMETQPCNKPK------TGHEGHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVKI-NGANKFICTQGPTEKTVDDFYRLIWQEK
.....|| .||....   . |      . .| . .||||||.   | .||.|.  |... |||| ||..|  .|  ..| .|||  ||.|||.|.||. .
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwekn

APCVVMLCNIMECGKKKCEQYWPETADGQMILmdGKLTVKIAEpAKEVEQNILlMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLK---
   |||.|...| ||||||.||||. . ..    |...|.  |  | |....| ..   .. ...|.... ....||||.|||. .  ...|.  ..   
veivvmaCrevelgkkkCerYWpeegeeelef..gefevtlee.ekavdddfl.irtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq

--TASPIVVHCSAGIGRTGSIVGLEIALVKFCAG---EKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
   ..|.|||||||.|||| |. ....   . |.   |.. . |.| |.|.||.  |||  || .... .. | ..
esedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 72-332 6.3e-43 142.0 In-house 21-289 (297) alignment 
Range on Protein: 72-332
Range on HMM: 21-289/297.0
KQLSTEFLNLKMETQPCN--KPKTGHEGH--PEKNRYKDVYCIDDTRVVLKWPEDS-PSDYIHANWVKINGAnKFICTQGPTEKTVDDFYRLIWQEKAPC
|. .|.. . ..   |    .|.|  | .   ||.|||..  .|  || |.  .|.  |||. | .|| |   ..|.|| | . ||.||......|..  
knrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvst

VVMLCNIMECGKkKCEQYWPETADGQmilmDGKLTVKIAEPAKEveQNILLMKITVIDDK-GTSHNFEHWQWKAWPDRGVPE--LPMAVFRLLIRLK---
.||| .  |  | || .||....  .     |...|..   ..   .  .  ...|  .|  . .  . .|.  |||. |..     ..  |.  ..   
ivmlnddnerdk.kcaryWsdkgvtt....fGdvsvvllsvser..eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdf

---TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA--LAENR
   . .|..|||.||.|||| .. ..  . .    ..| . ..|| .|..|   |||. || |.. ..|   |.|. 
sqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
DSPc_SM00195 73-329 2.4e-86 284.7 In-house 1-262 (263) alignment 
Range on Protein: 73-329
Range on HMM: 1-262/263.0
QLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED-SPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVML
.|..|| .|...|.|... .. ..   .|||||.....|.||| ||..|. ..||||.||..|..   .|.|.||||...||.||.|..|.|| ...|||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CNIMECGKKKCEQYWPETADGQMILMdgKLTVKIAEPAKEV-EQNILLMKITVIDDkGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-----SP
.. .|.||.||..||||...|..     |..||. |  |.  | ..  ...|  ..  ........|.|.|||.|||. .. |..||  .|.      .|
teeeengkekcdrywpeesggketfg..kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
||||||||.||||..| ..|.| |.....|| ...||||.|.||.|.|||..||||.....|...
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 73-329 2.4e-86 284.7 In-house 1-262 (263) alignment 
Range on Protein: 73-329
Range on HMM: 1-262/263.0
QLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED-SPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVML
.|..|| .|...|.|... .. ..   .|||||.....|.||| ||..|. ..||||.||..|..   .|.|.||||...||.||.|..|.|| ...|||
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

CNIMECGKKKCEQYWPETADGQMILMdgKLTVKIAEPAKEV-EQNILLMKITVIDDkGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-----SP
.. .|.||.||..||||...|..     |..||. |  |.  | ..  ...|  ..  ........|.|.|||.|||. .. |..||  .|.      .|
teeeengkekcdrywpeesggketfg..kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
||||||||.||||..| ..|.| |.....|| ...||||.|.||.|.|||..||||.....|...
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045098 (Phosphotyrosine protein) phosphatases II 73-331 7.1e-67 221.0 In-house 8-274 (278) alignment 
Range on Protein: 73-331
Range on HMM: 8-274/278.0
QLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVlkwpedspsDYIHANWVKINgANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCN
.|..|| .| .  .|.       .|. .||||||....| .||.         |||.|.....   .|||.||||...||.||.|..|... ...|||..
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmlte

IMECGKKKCEQYWPEtaDGQMILmdGKLTVKIAEPAKEveQNILLMKITVID-----DKGTSHNFEHWQWKAWPDRGVPELP--MAVFRLLI----RLK-
 .| |..||.|||||  .| ..   |..||.. .      ... | ...|..       ..|....|.... ||| |||.||  . ...||     .|| 
lvelgrekcaqywpe..ggslty..gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------TASPIVVHCSAGIGRTGSIVGLEIALVKFcaGEKVVLKDIVKEIRNQRHG-SVQTDAQYLFMHRVLLALAEN
                |..||||||.|||| .|.. . |  .  ...| | ..|||.|.||.| .||.  || |....|| | ..
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 73-170 1e-10 35.7 In-house 12-116 (347) alignment 
Range on Protein: 73-170
Range on HMM: 12-116/347.0
QLSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKwPE-------DSPSDYIHANWVKINGA-NKFICTQGPTEKTVDDFYRLIWQEKA
 ||| | .   .  | .   .  |   .||| |||  ||.|||||  ||       | .  || |  .|.. | ...| || |  .|| ||....   | 
slstyfdenlanyspskftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv

PCVVML
  || .
tqvvti
0046845 (Phosphotyrosine protein) phosphatases II 74-331 1.4e-75 249.6 In-house 2-276 (284) alignment 
Range on Protein: 74-331
Range on HMM: 2-276/284.0
LSTEFLNLKMETQPC--NKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPED--SPSDYIHANWVKI------NGANKFICTQGPTEKTVDDFYRLIWQEK
|  ||  | . | .   .   . .. . .||||||... |..||.||....  . ||||.|..|.       .  .|||.||||...||.||.|..|...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

APCVVMLCNIMECGKKKCEQYWPETaDGQMILmdGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT--
....|||....| |..||.||||.. .. ...  |..||.. .  ..    .  ...| .. .| |.   |.....|||.|||. |  ....|  ...  
vrvIVmltelvengrekcaqYwple.gevlty..gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGE---KVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
      .|||||||||.|||| .. |...|  . ...   .| . ..|| .|.||.|.||| .||.| ...|| .. .
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_PTPN13_pd Subfamily PTPN13 74-328 3e-57 189.0 In-house 13-268 (273) alignment 
Range on Protein: 74-328
Range on HMM: 13-268/273.0
LSTEFLNLKmETQPCNKPKTGHE-GHPEKNRYKDVYCIDDTRVVLKwpEDSPsdYIHANWVKIN-GAN--KFICTQGPTEKTVDDFYRLIWQEKAPCVVM
 . || .|. | .| .. ..|..  . .||||..|  .|.||| |.  ....  || |...|.. | .  ..| .|||  .||.||....|. ||  ..|
Paeefkelr.elkpldtcevgkkkenkdknryrnvlPydetrvklg..degg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LCNIMECGKKKCEQYWPETADgQMILMDGKLTVKIAEPAKEveQNILLMKITVIDD-KGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR---LKT-ASP
. .  | || ||..||||... . . . ..|.|.  .  |   ..  . ...|.|   | |..  | .. .||| |||  .. . ... .   |.| |.|
vtlekekgkvkchrywPeskn.kklkvsnrlevellkvqkl..dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagP

IVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
|||||||||||.|... ....|      ... .|.||...|.||.| |||. ||.|.....| .
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Ptp69D_pd Subfamily Ptp69D 74-330 2.4e-52 173.0 In-house 24-287 (307) alignment 
Range on Protein: 74-330
Range on HMM: 24-287/307.0
LSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLK-WPEDSPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLC
|  |. .|. .. . .   . ..    ||||.|.   |.|||.||  . .  |||| |...|     .|||. |.| | |..||.|.|.. .   .||| 
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

NIMECGKKKCEQYWPETadgqMILMDGKLTVKIAEPAKEVEQNILLMKITVIDDKG----TSHNFEHWQWKAWPDRGVPELPMAVFRLLIRL-----KTA
|. |  .|||..|||.      .   |.. ||...  |  .  |  .... .....     |..   .....|.|  ||| . ....|. ..     .  
nlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnr

SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAE
|||||||||| ||.| .| |.. | .  | .|| . ..||..|.||   ||  .|| |..| ||   .
sPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 74-247 9.5e-31 101.7 In-house 9-181 (297) alignment 
Range on Protein: 74-247
Range on HMM: 9-181/297.0
LSTEFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPeDSPSDYIHANWVKING---ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVML
| .|   |  |... .   .  ..   ||||.|.   ||||| |.    . .||| |..|         |.|..|||...|||||..|....    .||.
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrv.iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

CNIMECGKKKCEQYWPETADGQMilMDGKLTVK-IAEPAKEVEQNILlMKITVIDDkGTSHNFEHWQWKAWPDRGVPE
... | |..||  |||.. ....    |.. |. ... . | .. ||  ....|     |    | |. .||| ||| 
aklqedGrdkcapywpsvvqerl..kagdvvveflsstsdefdrvil.telqliyr.sesrvvrhvqflswpdhGvps
subfamily_PTPRN_pd Subfamily PTPRN 76-323 3e-32 106.5 In-house 33-286 (297) alignment 
Range on Protein: 76-323
Range on HMM: 33-286/297.0
TEFLNLK-METQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWP-EDSPSDYIHANWVKING--ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLC
 |.  |.  |..|. |  . .|   .|||.|.|   |..|| ||   ... |||| |  .  .   |  .| ||||  .|| ||....|.. .  .|.|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

NIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPAKEVEQNILLMKITvIDDKGTshnFEHWQWKAWPDRGVPELPMAVFRLLIRL-----KTASPIV
.. | | |.|..|||..      . . .|  .       . . . |  .   ..  |      . . .||..|||  . ... .  ..       ..|||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq.tsetrt...vtqfhflswpeegvPasaksllefrrkvnksyrGrscpiv

VHCSAGIGRTGSIVGLEIALVKFCAGEKV-VLKDIVKEIRNQRHGSVQTDAQYLFMHR
||||.| ||||  . ... | ..  | |   .   .. .|.||.| |.| .|. |.  
vhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_PTPN14_pd Subfamily PTPN14 77-329 7.2e-40 131.8 In-house 28-296 (300) alignment 
Range on Protein: 77-329
Range on HMM: 28-296/300.0
EFLNLKMETQPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDSPSDYIHANWVKINGA---NKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNI
|. ... . . ..   .  .   ||||.|||   .|.|| |.  ... ..|| |  .|.  .    ..| .||| |.|| ||....|...   .||| ..
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

MECGKKKCEQYWPETADGQMILMDGKLTV--KIAEPAKEVEQNILlmKITVIDdKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRL-----KT-----
 | ||.|. .|.|.. . .  .  ||  |  |  | .. |  . |  |.  .   .   .  | |.. |||.|||| .   .  | ..     ||     
eedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittgl..klkhlp.skeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

----ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
      |..||||||.|||| ..  .. .  .  .|.. .| ... .|.||   ||| ||| |...||.   
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 86-326 2.3e-49 162.9 In-house 23-267 (285) alignment 
Range on Protein: 86-326
Range on HMM: 23-267/285.0
QPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVKINGAN--KFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQ
 | |   | .|  |. ||| || ||..||||||   .   |||||.|... | .   .| ||||  .|. ||...|.|||   |.||| ..| | .||  
mppnctytayeanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcal

YWPETAdGQMIlMDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSH---NFEHWQWKAWPDRGVPELPMAVFRLLIRLKT----ASPIVVHCSAGIGRT
|.||   |...   ||  . ..|  .|     .|  .|||. . .|     ..| |   |||.  ||    .  |   .|       ||.||||||.|||
yypekl.gevv.kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrt

GSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
 ..||.. | ..     .. . |||.|.|  |  .||.  |.||.. ||.
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 86-326 2e-43 143.5 In-house 36-276 (439) alignment 
Range on Protein: 86-326
Range on HMM: 36-276/439.0
QPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVL-KWPEDSPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKkkceq
  |.   . .|    |||||||   | |||.| . |    | || ||..|     . .| ||||...|.|||.||....|.  .|||.|..|  |     
yaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....

YWPETADgqMilMDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTS-HNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT------ASPIVVHCSAGIGRT
|||  |.  .  . | ..|..    .  .  |  .|.    |..   .   .... ||||. ||     |  .|  ...        |.|||||||.|||
ywpsdae..v..cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

GSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
|.|. |.||| .. . .|| .| ||| .|.||.  ||. .||.|..  .|
Gtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 86-329 1.8e-42 140.6 In-house 36-288 (325) alignment 
Range on Protein: 86-329
Range on HMM: 36-288/325.0
QPCNKPKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDS-PSDYIHANWVKI-NGANKFICTQGPTEKTVDDFYRLI--WQekaPCVVMLCNIMECGKKKC
..  |  ...    .|||.|.|  .| .||||.  .|.  |||| |....   . . |. .| |  .|..|..||.  |.     ||.. |... ||..|
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrc

EQYWPETADGQMILmdGKLTVKIAEpAKEVeQNILLMKITVIDD-KGTSHNFEHWQWKAWPDRGVPELPMAVFRLL---------IRL--KTASPIVVHC
 .|||.       .  | | ||.   ..|.  . .  .. | .  || .   . .|...|.| ||.. | ..  .|         ..   |...||.|||
avywpkemgksktf..Gglevklrt.ieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhc

SAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
|||.||||  . |  || |     .| . . || .|..|   |.|  || ...  |    
saGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN1_pd Subfamily PTPN1 91-326 7.3e-48 157.8 In-house 25-268 (290) alignment 
Range on Protein: 91-326
Range on HMM: 25-268/290.0
PKTGHEGHPEKNRYKDVYCIDDTRVVLKWPEDspsDYIHANWVKINGAN-KFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETA
 .. ..   ..|||.||   | .|..|.  .    ||| |. |... |. ..| ||||  .||| |....|..|. .|||| ...| .. || ||||.  
reaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqge

D-GQMILMDGKLTVKIAEpaKEVEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-------SPIVVHCSAGIGRTGSIV
.  ...| | ||.||. .  .|....  . .. . .     ...  |. . .||| |||| | | ...| ... .        | |.||||||||.|...
eekellledtklkvklis..eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc

GLEIALVKFCAGEK---VVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
 ..  ||.  . ..   | .|. . |.|..|.| .||  |  | .  .|
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylail
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 93-335 2.9e-42 139.5 In-house 28-274 (283) alignment 
Range on Protein: 93-335
Range on HMM: 28-274/283.0
TGHEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVKIN----GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPET
.  . ...|||....   |  || ||     . ||| | .. ..      .|.| .|.| ..|| ||......||. ..||| ...|  ..|| ||||. 
asadenkrknrnqeivpadqwrvelk...sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

ADGQMilmdGKLTVKIAepaKEVEQNILLMKITVIDDKGTSHN---FEHWQWKAWPDRGVPE--LPMAVFRLLIRLKT---ASPIVVHCSAGIGRTGSIV
   .     |..|| .    ||. .| . .|  ..  ......     |.|   | . |       .  | ..| |.|    .|||||||.|||||.  .
Gsedy....Geftvtlr...kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

GLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL--ALAENRKIT
..  .. .  .   | .  .|| .|.|| . |||  || ..| . |  ||. . .|.
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 94-335 2.8e-47 155.7 In-house 33-275 (281) alignment 
Range on Protein: 94-335
Range on HMM: 33-275/281.0
GHEGHPEKNRYKDVYCIDDTRVVLKW--PEDSPSDYIHANWVKINGA-NKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAD
 .    .|||| .. |.| .|| ||   |.   .||||||...       .| |||| ..|  ||.|.||||.. ..||||...|  ..|| .|.|  | 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

GqmILMDGKLTVKIAEpaKEVEQNILLMKITViDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-SPIVVHCSAGIGRTGSIVGLEIALVKF
    |   ||.|.  .    |.. ..  .. .   .| ..   || || |||  |||    ....| ....  .| |.|||||.||.|... .||||   
c..clqfdklsvsyed..stvnkslvttrlnl.syegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsi

CAGEK-VVLKDIVKEIRN-QRHGSVQTDAQYLFMHRVLLALAENRKIT
 .      .|.||  .|   |  ||||  ||... .||| .    |  
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 95-326 4.9e-31 102.5 In-house 42-233 (392) alignment 
Range on Protein: 95-326
Range on HMM: 42-233/392.0
HEGHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGkkkceqywpetadgq
.|   .|||||..  .| .||.|.  .|.| |||. | ... ..  . .|..|||   ..|||.|...||..  ..|. .. |                 
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

milmdgkltvkiaepakeveqnillmkitviddKGTSH-NFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-----SPIVVHCSAGIGRTGSIVGLEIAL
                                 || ..     ...  |||..||.   ......  .|.       |...|||||.|||| .. ..  .
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvv

VKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
 .      | . ..| .||..|   |||. || |..  .|
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 95-332 4.8e-29 96.2 In-house 30-262 (267) alignment 
Range on Protein: 95-332
Range on HMM: 30-262/267.0
HEGHPEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVKI-NGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLcniMECGKKKCEQYWPETAdGQM
 |   |.||. |.   |||||.|.   ..  .|| | .|.  .  |.|| ||.| ..|. ||. .| ..| | .|.|   .  .. .  ..||    || 
aeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll...tkvftdnirlfwPPkm.gqa

ILMdGKLTVKIAEPAKEVEQNILLMKITVIDDkgTSHNFEHWQWKAWPDRG--VPELpMAVFRLLIRLK---TASPIVVHCSAGIGRTGSIVGLEIALVK
      |||. .   .| . .|. ... . ..  ..||   . .| |       | |   .| .| . .      |.||.||.|.||.|. . ..  | .
kky.qdltvehslekeendyqiitlelkfkne..sahnvtlyyykkwnintnnkpyl.kplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqler

FCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENR
    . . . | ...||.|| | |.|  .|...|..|   || |
aktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_PTPRK_pd Subfamily PTPRK 96-348 2.6e-48 159.4 In-house 41-298 (314) alignment 
Range on Protein: 96-348
Range on HMM: 41-298/314.0
EGHPEKNRYKDVYCIDDTRVVLKWPEDS-PSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGqm
. . ||||..|.   | .||.|.  ..   |||| |...   . ...|| |||| ..|| ||.||...|.. ..||| ...| |. || .|||| ..   
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..

ilmDGKLTVKIAEPAKEVEQNILLMKITV-IDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-----ASPIVVHCSAGIGRTGSIVGLEIALV
    |.. |.. |   . |  . .....     .   .   ..|. .||| .||    ....|. |.|.     | .|||||||| ||||  . ..| | 
...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld

KFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA--LAENRKITSPELSAFVAEYDK
     . | .  .||..|...   |.|  || |.. |.|   |. .  |   |. |   |  .
mieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesir
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 96-327 1.2e-43 144.1 In-house 42-275 (315) alignment 
Range on Protein: 96-327
Range on HMM: 42-275/315.0
EGHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVKINGA-NKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETaDGQM
.   .|||||..  .| .||.|.  .||| |||| |  .|     . .|..||| . .||||.|...|||.  .||. .  |  | || ||||.  ... 
tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr.kads

ILMdGKLTVKIAEpaKEVEQNILLMKItVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-----ASPIVVHCSAGIGRTGSIVGLEIALVK
. . |.. |.. .   |   .    |. |. .  .|..   .|.. |||.||..   ....|.  .|.       ...||||||.|||| .. ..  . .
vef.Gsikvells..leadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaq

FCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
   .. | . ..||..|..|   |||. .| |.. ..| 
ikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
0040439 (Phosphotyrosine protein) phosphatases II 97-327 2.6e-64 212.5 In-house 10-244 (249) alignment 
Range on Protein: 97-327
Range on HMM: 10-244/249.0
GHPEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPEtaDGQMI
 ...||||.|... | .||.|.  |.  .||||.|....     ..||.||||...||.||.|..|...  ..|||.. .|.|..||.||||.  .| . 
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsle

LmdGKLTVKIAEPAKevEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-------ASPIVVHCSAGIGRTGSIVGLEIAL
   |..||.  .  .  .... . .... .  .|.|.   |.|.  ||| |||. .  ..... ....        .|..||||||.|||| .... ..|
y..gdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

VKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
  .    .| |...||..|.||.|.||.. || | ...|| 
eqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 97-328 1.8e-63 209.5 In-house 8-242 (245) alignment 
Range on Protein: 97-328
Range on HMM: 8-242/245.0
GHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVKING-ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPEtaDGQMI
 ...||||.|... |.|||.|.... .. ||||.|..|.     .|||.||||...||.||.|..|...  ..|||.. .| |..||.||||.  .. . 
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt

LmdGKLTVKIAEPAKevEQNILLMKITVID-DKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT------ASPIVVHCSAGIGRTGSIVGLEIALV
   |..||.  .  .  .... . ...| .  .. |..  |...  ||| |||.|.  ....| ....        |..||||||.|||| .... ..| 
y..gdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

KFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
 . .  .| | ..|||.|.||.|.|||. || |....|| |
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_egg_pd Subfamily egg 97-329 3.8e-46 152.2 In-house 39-270 (307) alignment 
Range on Protein: 97-329
Range on HMM: 39-270/307.0
GHPEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVKING-ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECgkKKCEQYWPETADGQMI
 . || | | | | | .|| |. ..     |.|||| || .   |.||..| |   |||||.|...||. . .|||    |   ..|| ||| . .  ..
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslv

LMDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKaWPDRGVPELPMAVFRLLIRLktASPIVVHCSAGIGRTGSIVGLEIALVKFCAG--
.. | | ..  .  .. .    . |. ..  .      ||||.  .   .    |. |.|.| .|  . |.||..  |. .....| .||||...  |  
tvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.vnnssdvysplrvlrklrnl..skpvvvqdilGvskaatlvaieiallsllrGpi

EKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
 | ...  |. .| .|. ||..  .|||..|..| . 
tkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0049772 (Phosphotyrosine protein) phosphatases II 97-328 3.5e-39 130.8 In-house 45-279 (314) alignment 
Range on Protein: 97-328
Range on HMM: 45-279/314.0
GHPEKNRYKDVYCIDdTRVVLKWPEDSPSDYIHANWVKINgaNKFICTQGPTEKTVDDF----------YRLI--WQEKAPCVVM---------------
 ...||||.|... | .||.|.  . | ||||.|..|.    .|||.||||.| ||.||          .|..  .. .   .||               
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCNIMECGkkkceqywpetadgqmilmdgkltvkiA----------EpakeveqnillmkiTVI--DDKGTSHNFEHWQWkAWPDRGVP--ELP
      |..... |                           .          .              ...  ... . ........  .|| ..|  |  
AlgKtpllildgng...........................neptaadlellk..............eelydpelferlgikylri.pvpDgsaplledf

MAVFRLLIRLKTASPIVVHCSAGIGRTGS-IVGLEIALVKfcageKVVLKDIVKEIRNQRH-----GSVQTDAQYLFMHRVLLAL
 ...... .... .|..|||.||.||||. .|   . .       .| |.......|..|.     |....  ||.|....|| .
deflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealley
subfamily_CG7180_pd Subfamily CG7180 97-326 8.2e-30 98.4 In-house 41-287 (296) alignment 
Range on Protein: 97-326
Range on HMM: 41-287/296.0
GHPEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKkKCEQYWPETADGQMi
   ||||. .|   | .||||.    .. |||| | .|      ...| |..|...|||.|.||...|.. .||.|.. ..  | .. .|||...  |  
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy.

lmdGKLTVKIAEPAKEVEQN---ILLMKI------TVIDDKGTSHNFEHWQWKAWPD-RGVPELPMAVFRLLIRL----------KTASPIVVHCSAGIG
   |.. |.| |  .  . .   . |.|       .  . |       . |.. |.    ||    |.  |. |           .. .|.||..| | .
...geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGas

RTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
|.|  ......| .    |.| . . || .|..| . |..  .| ..  |||
RsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
0037934 (Phosphotyrosine protein) phosphatases II 98-326 8.8e-61 200.9 In-house 10-239 (243) alignment 
Range on Protein: 98-326
Range on HMM: 10-239/243.0
HPEKNRYKDVYCIDDTRVVLkwpEDspSDYIHANWVKINgaNKFICTQGPTEKTVDD----FYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPetadGQM
. .||||.|... |..||.|   |.  ||||.||....   ...|.||||...||.|    |.|..|...  ..|||.. .| |..||.||||    |..
nlsknrysdilpydhsrvkl...eg..sdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....gev

ilMDGKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLL---I----------RLKTASPIVVHCSAGIGRTGSIV
  . |..||.. .     .  .  .... .| .. ...  |... .||| |||. |  . ..|   .           |.. .|..||||||.|||| ..
..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

GLEIALVKFcageKVVLKDIVKEIRNQRHG-SVQTDAQYLFMHRVLL
 . . | ..    .| | ..||..|.||.| .|||  || | ...||
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 98-330 4.7e-37 122.7 In-house 19-260 (290) alignment 
Range on Protein: 98-330
Range on HMM: 19-260/290.0
HPEKNRYkDVYCIDDTRVVLK-WPEDSPSDYIHANWVKINGANKFICTQGPTEKT-------VDDFYRLIWQEKAPCVVMLCNIMECGKK----KCEQYW
|  ..|. .|  . .|||||| . .   .|||||| |..    ..| || | ||.       . .|. .. |||.  |||||. .|  ..     |..| 
hemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PETADGQMILMDGKLTVkiaePAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-ASPIVVHCSAGIGRTGSIVGLEI
||...... . . ..        || |...   ...|  |..  . ..| . | | .. |.| .  .  |.  .|.  .|..|||  || |   .  ...
pesvgeelkfkgltvkC....kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiil

ALVKFC-AGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAE
.  |.    ..|.|.|..|..|.||   .... .. |.  ... || 
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllai
Y_phosphatase Protein-tyrosine phosphatase 99-326 2.4e-72 238.5 Pfam-A 2-234 (235) alignment 
Range on Protein: 99-326
Range on HMM: 2-234/235.0
PEKNRYKDVYCIDDTRVVLkWPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGqmILMD
 .||||||. ..|.||| |   ...|||||.||.||  .  .|||.||||...|..||.|..||||  ..|||.. .| |..||.|||||. ..   |. 
kkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..slty

GKLTVKIAEPAKEVEQNILLMKITVIDDKGTS--HNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTAS-----PIVVHCSAGIGRTGSIVGLEIALVKFC
|...|.. |  || |... | |... ..|. |  . ........|||.|||| | ....|. .... .     |.|||||||.||||..| |.|.| .. 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
|.|.| ...||||.|.||.|.||. .|| |.....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 99-326 2.4e-72 238.5 In-house 2-234 (235) alignment 
Range on Protein: 99-326
Range on HMM: 2-234/235.0
PEKNRYKDVYCIDDTRVVLkWPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGqmILMD
 .||||||. ..|.||| |   ...|||||.||.||  .  .|||.||||...|..||.|..||||  ..|||.. .| |..||.|||||. ..   |. 
kkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..slty

GKLTVKIAEPAKEVEQNILLMKITVIDDKGTS--HNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTAS-----PIVVHCSAGIGRTGSIVGLEIALVKFC
|...|.. |  || |... | |... ..|. |  . ........|||.|||| | ....|. .... .     |.|||||||.||||..| |.|.| .. 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

AGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
|.|.| ...||||.|.||.|.||. .|| |.....|
aeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_PTPN3_pd Subfamily PTPN3 99-331 3.5e-59 195.0 In-house 42-277 (280) alignment 
Range on Protein: 99-331
Range on HMM: 42-277/280.0
PEKNRYKDVYCIDDTRVVLKwpeDSPSDYIHANWVK--ING---ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQM
 .||||.|.   |.||| ||   .|..||| ||.|.  |..    |..| |||| .||. ||....|..|.  .||| ...| |..|| |||||| | . 
lsknryrdilpydatrvklk...esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedele

IlmdGKLTVKIAEPakEVEQNILLMKITVIDDK-GTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-----SPIVVHCSAGIGRTGSIVGLEIALV
    |...||. .   . .....| .... | .   ...  . |. |||| |||. .  ..... |....     .|.|||||||||||| .. ||.|| 
y...gefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala

KFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
.  | |.|   |||...|.||   ||| .|| |.   .|.. |.
lieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 99-332 1.6e-57 189.6 In-house 21-267 (270) alignment 
Range on Protein: 99-332
Range on HMM: 21-267/270.0
PEKNRYKDVYCIDDTRVVLK-WPEDSPSDYIHANWVK--INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMIL
.. |||.|.     |||.|.   ||| . || ||.|.   .  .|.|...||.. |. .|.|.||.||....||. ...| |.||||.|||. .. .. |
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

MDGKLTVKIAepAKEVEQNILLMKITVIdDKGTSHNFEHWQWKAWPDRGVPELPM------AVFRLL-------IRLKTASPIVVHCSAGIGRTGSIVGL
.|||..|     ..| |.  .| ....  .||....  |.....|||.|||. .        . ..|        .|. |.|..||||||.|||| .. |
edgkikvlal..seekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlial

EIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENR
.||.      .|| .  |..|.|..|   ||.  || |......  || |
DiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 99-327 2.3e-45 149.7 In-house 44-274 (515) alignment 
Range on Protein: 99-327
Range on HMM: 44-274/515.0
PEKNRYKDVYCIDDTRVVLKWPEDSP-SDYIHANWVKIN-GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdGQMIlM
 .|||||..  .| .|| |.  .|.| |||. |  ..     . .|..||| . .||||.||..||.   ..|. .  |  | || .|||.   |. .  
fkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp.gdsv.k

DGKLTVKIAEPakEVEQNILLMKITVIDDKGtSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA-----SPIVVHCSAGIGRTGSIVGLEIALVKFCA
 |.. |..     |   . .  |.||. ..  |.    .... |||.|||.   ....|.  .|.       |...|||||.|||| .. ..  . .   
fGsikvelvsl..eactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakt

GEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
.. | . ..|. ||..|   |||. || |.. ..| 
trmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 99-321 5.3e-44 145.2 In-house 51-273 (301) alignment 
Range on Protein: 99-321
Range on HMM: 51-273/301.0
PEKNRYKDVYCIDDTRVVLKwpEDSPSDYIHANWVKINGA-NKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILmd
 .|.||. | |  .| | .   .|     |||||.. .|  ..||.|||| ..| .||. .. | .   .|||.. .|  ..|||.| | .   .. .  
kdkhryptvPckPstavevi..vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi..

GKLTVKIAEPAKEVEQNILLMKITVIDDKG--TSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLK-TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEK
|. ..|| .  . ....|   .. | |  |  ...   |.|.. |.|||||.  . .| |.  .| .  ||||||||||||. . .| |.   .  |  .
grfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadpt

VVLKDIVKEIRNQRHGSVQTDAQYLFM
..|.. .|..|..|  .|||  |  .|
ieltealkhlrehrwngvqtnsqlywm
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 99-326 2.5e-39 129.8 In-house 39-274 (287) alignment 
Range on Protein: 99-326
Range on HMM: 39-274/287.0
PEKNRYKDVYCIDDTRVVLKWPEDSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETaDGQMILMd
 .|||| ||  ||||||.|    .  |||| ||.|   .  ..||..|||   || ||.|.......  |...   .| ...|| .||||  .  | .  
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvG.

GKLTVKIAEPAKEVEQNILLMKitVIDDKGTS-HNFEHWQWKAWPDRGVPELPMAVFRLLIRL----------KTASPIVVHCSAGIGRTGSIVGLEIAL
|   | .    || |  .  ..  .|| ..   .  .  .. .|||....   ... |. .            . . |.|||...||||.| .. . . .
GysvvlldydikePeygvralr..lidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

VKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
 .     .|    .|  .|..| . ||.  |. ..   | 
srledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_CG42327_pd Subfamily CG42327 99-261 1.4e-23 78.1 In-house 29-192 (319) alignment 
Range on Protein: 99-261
Range on HMM: 29-192/319.0
PEKNRYKDVYCIDDTRVVLKW-PEDSPSDYIHANWVKI--NGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETA--DGQM
 .|.|. .|  . .|||||.  ..|  . |..|..|.   .  | .|..| . |..  ||.|..|. ..  .| |... | | |.| .|.|  .  |.. 
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

ILMDGKLTVKIAEPAKEVEQNILLMKITvidDKGTSHNFEHWQWkAWPDRGVPELPMAVFRLLIRLKT
   | ..|.|  |  ..     ||.|     ||  | .  |. .  |.. .||  . |.. .|.. ..
lyGdilvtlkgrevkdryaistlllkrv...dkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 99-181 4.9e-07 23.5 In-house 35-118 (332) alignment 
Range on Protein: 99-181
Range on HMM: 35-118/332.0
PEKNRYKDVYCIDDTRVVLKwPEDSPSDYIHANWVKIN-GANKFICTQGPTEK-TVDDFYRLIWQEKAPCVVMLCNIMECGKKKC
 . ||   .||.| .|| |  |.|   |.  |.||      . .| .| | .  |   |.|.. . |   .... .| |  |.|.
mdmnriphlycfdhsrvela.pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 100-327 2e-49 163.1 In-house 11-240 (250) alignment 
Range on Protein: 100-327
Range on HMM: 11-240/250.0
EKNRYKDVYCIDDTRVVLKWPE-DSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKkCEQYWP-ETADgqmilM
||||| |.  .| .||||.  . |  |||| | ...  .. . || |||| ..|. ||.|....||.  .||| |. | .|. ..|||| |.|.      
eknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.....k

DGKLTVKIAEpaKEVEQNILLMKITVIDDKGTSH-NFEHWQWKAWPDRGVPELPMAVFRLLIRLK------TASPIVVHCSAGIGRTGSIVGLEIALVKF
 |..||.. .  ||.  ..   |. .   | ...    . .. .|||.||||   ||. || ...       ..|..|.||||.||.|. . ..  | . 
yGdvtvslls..keefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

CAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
   ..| . ...| .|..| ..|.. .|| |.....| 
kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 100-328 2.7e-45 149.7 In-house 51-278 (315) alignment 
Range on Protein: 100-328
Range on HMM: 51-278/315.0
EKNRYKDVYCIDDTRVVLKWPE-DSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETadgQMILmd
.|||| ..   | .|| |   | |. |||. ||...  |  ...|..|||   .|.||.||...|.   .||| |..|  |.|.|.|||.    ..|   
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy..

GKLTVKIAEpaKEVEQNILLMKITVIDDKgTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLK-----TASPIVVHCSAGIGRTGSIVGLEIALVKFCAG
||.||   .  .||....    ..|. ..   ..   ... .||| |||.  ...  |  . |     ....||||||||.||||. . |.  | .  | 
Gkitvtrks..eevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeae

EKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
. . . .... .|..| . ||. .|| |.. .||  
naidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 100-345 1e-44 148.2 In-house 27-273 (284) alignment 
Range on Protein: 100-345
Range on HMM: 27-273/284.0
EKNRYKDVYCIDDTRVVLKWPE-DSPSDYIHANWVK-INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCnimecgKKKCEQYWPETADGQmilmD
.|||. ..   | ..| |.       |||| | ...     .|.| |||| . |..||.|.||. ..  .|.|       |.|| ||||  .. .    .
dknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik....e

GKLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR-------LKTASPIVVHCSAGIGRTGSIVGLEIALVKFC
..  ||.    .  |  .  ....    .    .   . .. ||| |||. |. ..||. .        .  ..||||||||.||||  . |.. | .. 
erfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmk

AGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA--LAENRKITSPELSAFVAE
  ..| . ..|...|.||   ||  .|| |..  ||   |  .  .. |.. |.. |
eekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpaylee
0041856 (Phosphotyrosine protein) phosphatases II 100-335 9.7e-43 141.2 In-house 3-177 (182) alignment 
Range on Protein: 100-335
Range on HMM: 3-177/182.0
EKNRYKDVYCIDDTRvvlkwpedsPSDYIHANWVKINGAN-KFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCnimecgkkkCEQYWPetadgqmilmdg
.||||.|....| .|         ..|||.||..  .  . .||.||||. .|| ||.|......  ..|.|.         .|.|||            
dknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

kltvkiaepakeveqnillmkitviddKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTASPIVVHCSAGIGRTGSIVGLEIALVKfcageKVVLK
                           .   ..  ....  ||| |||.|....  . . |.   |..||||||.||||..|.. . ...     .| | 
...........................ellerlgiqylylpwpDhgvpdldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

DIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKIT
..||..|..|.|.|.|  || | ...|| | ...|..
eavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 100-326 1.5e-39 130.6 In-house 9-237 (239) alignment 
Range on Protein: 100-326
Range on HMM: 9-237/239.0
EKNRYKDVYCIDDTRVVL-KWPEDSPSDYIHANWVK-INGANK-FICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILm
 |||| ..   | .|||| |  .|  |||| |....  .|. | .|.|||  | .  ||.|..|||.   .|||  ..|  |||| ||||...     | 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.

dgKLTVKIAEpakeVEQNILlMKITVIDDKGTSHNF--EHWQWKAWPDRGVPELPMAVFRLLIR-----LKTASPIVVHCSAGIGRTGSIVGLEIALVKF
  ..|.. .|    |  . . ..  |. . | . .    ....  |||.|||.   ||. |  .     |  | | |.|||||.||||... ..  | . 
..rvtlrkte....vfadyi.irtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

CAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
   . | . . || ||..|   |||  ||.|.|  .|
kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 100-326 1.8e-39 130.3 In-house 10-238 (239) alignment 
Range on Protein: 100-326
Range on HMM: 10-238/239.0
EKNRYKDVYCIDDTRVVL-KWPEDSPSDYIHANWVK-INGANK-FICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILm
 |||| ..   | .|||| |  .|  |||| |....  .|. | .|.|||  | .  ||.|..|||.   .|||  ..|  |||| ||||...     | 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.

dgKLTVKIAEpakeVEQNILlMKITVIDDKGTSHNF--EHWQWKAWPDRGVPELPMAVFRLLIR-----LKTASPIVVHCSAGIGRTGSIVGLEIALVKF
  ..|.. .|    |  . . ..  |. . | . .    ....  |||.|||.   ||. |  .     |  | | |.|||||.||||... ..  | . 
..rvtlrkte....vfadyi.irtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

CAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
   . | . . || ||..|   |||  ||.|.|  .|
kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 100-349 1.5e-37 123.9 In-house 45-299 (312) alignment 
Range on Protein: 100-349
Range on HMM: 45-299/312.0
EKNRYKDVYCIDDTRVVLKWPEDSpsdYIHANWVKINGANK-FICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdGQMILMDG
. ||| .. | |  |  |   |.    |||||.|||    . |.||||| |.|.  |..|     . ....|| ..| | .|| .|  .   | . | | 
dlnrypniqcwdrgrftlagdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv.gfvdledh

KLT------VKIAEPAKEVEQNiLLMKItVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT-ASPIVVHCSAGIGRTGSIVGLEIALVKFCA
..       ..|   .|.      ..|. |.   |   ...|.|| .||| |.|.   . .|||  .|    |.. |||||.||||... .|  .  .  
rvyteycteieiggkskdkith.rvlkv.vvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrh

GEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKI---TSPELSAFVAEYDKV
  |  .||.   .|..|  ||.. .||..  |..| .  .. .      | . |   | |.
prkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyaki
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 100-190 7.4e-22 72.5 In-house 49-155 (350) alignment 
Range on Protein: 100-190
Range on HMM: 49-155/350.0
EKNRYKDVYCIDDTRVVLK---------WPEDSPSDYIHANWVKIN-------GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQ
 |||||..   . .|| ||             |..||| ||..|..          |.| ||.|. .||||||..| . | . ...| . .| . .||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPETAD
||.| . 
YWqegsy
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 100-325 8.3e-22 72.2 In-house 49-275 (303) alignment 
Range on Protein: 100-325
Range on HMM: 49-275/303.0
EKNRYKDVYCIDDTRVVLkwpedSPSDYIHANWVKINGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADgqmILMDGK
.|||. || |.| ..| |     | | ||||......  .| | || |  .|  ||...| ..|  ||..|    |  |   .  .|.  |   .|   .
dknrfvdvicldhskvkl.....sdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd...flkfee

LTVKIAEPAK-EVEQNILLmKITVIdDKGTSHNFEHW-QWKAWPDRGVPEL-----PMAVFRL---LIRLKTASPIVVHCSAGIGRTGSIVGLEIALVKF
 .... |  . |. .   | |.  .  .|. . | |  ..||||   .|          ...|   | .   ..| |    .| ||.|..  .| | . .
rsirvgefkrvelgdgwvl.kvlsv.sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

CAGEK-VVLKDIVKEIRNQRHGSVQTDAQYLFMHRVL
 . .  . |   .. .|| |  .||  .|. ... .|
hseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 101-326 4.1e-42 139.0 In-house 6-236 (237) alignment 
Range on Protein: 101-326
Range on HMM: 6-236/237.0
KNRYKDVYCIDDTRVVLKWPEDSpSDYIHANWVK-INGA-NKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMIlmdG
|||| .. . | .||||| .  . |||| |...| ..|. .|.|..||| | . |||....||||   .|||  ..|  ..|| .|||.| . .     |
knrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay...g

KLTVKIAEPAKEVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIR-------LKTASPIVVHCSAGIGRTGSIVGLEIALVKFCA
.||| .    .  .  .  . ...   .        .|. .|||||||.   |..|.  .       .  ..| ..|||||.|||| .. ..  | .   
vltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqake

GEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
 . | . . |. | ..|   .||  ||.|.|...|
kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 101-189 2.1e-14 47.6 In-house 51-157 (349) alignment 
Range on Protein: 101-189
Range on HMM: 51-157/349.0
KNRYKDVYCIDDTRVVLKWPEDS---------------PSDYIHANWVK---INGANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCE
||||||..  . .||.||    |               . ||| ||..|   |.  .|.|.|| |   ||||||..|  .. . |. | .  | . .||.
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

QYWPETA
.|| | .
iywqels
0044763 (Phosphotyrosine protein) phosphatases II 110-332 5.5e-29 96.4 In-house 2-174 (178) alignment 
Range on Protein: 110-332
Range on HMM: 2-174/178.0
IDDTRVVLKWPED-SPSDYIHANWVKingANKFICTQGPtektvDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADgqmilmdgkltvkiaepa
.|.|||.| ..|.   ||||.|...     . ......|      |...|.....  ..|.|.. .|.|. || .|||| |.                  
ldrtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................

keveqnillmkitviddkgtshnFEHWQWkAWPDRGVPELPMAVFRLL----IRL-KTASPIVVHCSAGIGRTGSIVGLEIALVKfcageKVVLKDIVKE
                       ... ..  .|| |||.|.  .....      | .  .|..||||||.||.|..| . . ..      .. | .....
.......................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

IRNQRHgSVQTDAQYLFMHRVLLALAENR
.|..|   |... |. ..... | | ...
vrerRp.ivpnpgqlrqLyefelrllkes
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 110-202 2.9e-06 19.0 In-house 56-149 (327) alignment 
Range on Protein: 110-202
Range on HMM: 56-149/327.0
IDDTRVVLKwpeDSPSDYIHANWVKINGANkFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNI---MECGKKKCEQYWPETADGQMI--LMDGKLTV
| | | ||     |  ...  ..|...||. .|  | ||.|.    .|.| ...   .| ||           ||  |.|   . .|   || | |..
irdnrrvlc...gsdeeffpgqyvrmegae.yiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsi
subfamily_eak_pd Subfamily eak 111-247 5.2e-10 33.2 In-house 64-196 (332) alignment 
Range on Protein: 111-247
Range on HMM: 64-196/332.0
DDTRVVLKWPEDSPSDYIHANWVKING-ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETAdgQMILMDGKLTVKIAEPak
|   | |      .  || |  .. .   .|.| |  . |. |  |.... ..|.|..|.| . .| . .| ..|.|. .  .  |  |.| |.  |   
drylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdkt..reelkfGildverkef..

eVEQNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVPE
 |..||| ..  ..     .|.  |..   | .  .| 
.vkrniletrllelskGnethrvlhykvfGwtettlpk
0046846 (Phosphotyrosine protein) phosphatases II 117-329 2.7e-39 130.1 In-house 4-173 (176) alignment 
Range on Protein: 117-329
Range on HMM: 4-173/176.0
LKWPEDSPSDYIHANWVKINganKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMilmdgkltvkiaepakeveqnil
... .| ..|||.||..  .   ..|.||||...|. || .......  .||.|.. .| |. || .||||  . ..                       
rllgldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

lmkitviddkgtshnfeHWQWKAWPDRGVPELpMAVFRLLI----RLKTASPIVVHCSAGIGRTGSIVGLEiaLVKFcaGEKVVLKDIVKEIRNQRH-GS
                 ....  ||| |||.|  ....||     .||   |..||||||||||| .| .   |..   .  . . ......|.||. |.
.................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay..llel..ekglsveealalvreqRplga

VQTDAQYLFMHRVLLALA
|||..|| | ....| | 
vqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 122-322 1.3e-34 114.7 In-house 2-154 (172) alignment 
Range on Protein: 122-322
Range on HMM: 2-154/172.0
DSPSDYIHANWVKINGA-NKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNImecgkkkceqywpetadgqmilmdgkltvkiaepakeveqnillmki
|..||||.|......   ..||.||||.  |..||.|......  ..|.|..                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

tVIDDKGTSHNFEHWQWKAWPDRGVPeLPMAVFRLLI------RLKTASPIVVHCSAGIGRTGSIVGLEIALvkfcagEKVVLKDIVKEIRNQRHGSVQT
 . | .. ...  ....  ||| ||| |.  . ..|        |.   |..||||||.|||| .| . . |      ... | ..|...|..| |.||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

DAQYLFMH
. || | .
psqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 125-337 1.6e-45 151.2 In-house 4-233 (272) alignment 
Range on Protein: 125-337
Range on HMM: 4-233/272.0
SDYIHANWVKINGA----NKFICTQGPTEKTVDDFYRLiWQEKAPCVVMLCNIMECGKKKCEQYWP--------ETADGQMILMDGKLTVKIAEPAKEVE
|.||.|..|. .|     .......||.. |..|| || ....  ..|.|.. .|.|. ||..|||           |. .    |.|.|.. .      
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

QNILLMKITVIDDKGTSHNFEHWQWKAWPDRGVP-ELPMAVFRLLIRlktASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVV--------LKDIVKE
  .  . .| . . |... . |... .|||.||| |   ....|| .     |..||||||..||| .| | . |  ...   |         | ..|.|
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee

IRNQRHGSVQTDAQYLFMHRVLLALAENRKITSP
.| ||.|.|||..|||| ...||.|...   ...
lraqrpgavqteeqylflyeallellrsllsvra
0036282 (Phosphotyrosine protein) phosphatases II 125-323 9.9e-36 118.4 In-house 2-164 (174) alignment 
Range on Protein: 125-323
Range on HMM: 2-164/174.0
SDYIHANWVKIN-GANKFICTQGPTEktvddFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPEtadgqmilmdgkltvkiaepakeveqnillmkitvi
||||.|......   ...|..|||..     |........  .||||.. .| |. || .||||                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

DDKGTSHNFEHWQWKAWPDRGVPELPMaVFRLLIRLKTA------SPIVVHCSAGIGRTGSIVGLEIALVKFCaGEKVVLKDIVKEIRNQRHGSVQTDAQ
. .  ...  ....  |||.|||.|.. ..... ....|       |..||||||.|||| .|.. . |.  .    |   |.|.|.|.||.|.|||. |
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YLFMHR
| | . 
yrflyy
0051082 (Phosphotyrosine protein) phosphatases II 125-325 4.2e-31 102.9 In-house 3-149 (151) alignment 
Range on Protein: 125-325
Range on HMM: 3-149/151.0
SDYIHANWVKINgankFICTQGPTEktvdDFYRLIWQEKAPCVVMLCNIMECGkkKCEQYWPETAdgqmilmdgkltvkiaepakeveqnillmkitvid
||||....|  .    .....||..    ||..|.....  ..|.|.. .| |  .| .|.||.                                    
sdyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

dkgtsHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKT--ASPIVVHCSAGIGRTGSIVGLEIALVKfcagekVVLKDIVKEIRNQRHGSVQTDAQYLFMH
     ... |...  ||| |.|... || ..|  |      |..||||||.|||| .|.| . | .      | | ....|.| .|.|.||.  |.|| .
.....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

RVL
..|
fal
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 137-323 6.5e-15 49.8 In-house 3-198 (199) alignment 
Range on Protein: 137-323
Range on HMM: 3-198/199.0
GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPAKEVEQNILLMKITVIdDKGTSHNFEHWQ
|  ..|.|| |  .|. ||....|.  .  .||. .     .     ||| |  |        .|.|      .     |..   .     .. .  |.|
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.appstreishyq

WKAWPDRGVPELPMAVFRLLI-R-------LKTASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEK--VVLKDIVKEIRNQRHGSVQTDAQYLFMHR
. .| ..  |.. . |  ..  |        .  .|..|||| | | || .| |.| .          | | .. | .|. | | . .  .| |...
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 137-323 6.9e-15 49.7 In-house 2-197 (198) alignment 
Range on Protein: 137-323
Range on HMM: 2-197/198.0
GANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPAKEVEQNILLMKITVIdDKGTSHNFEHWQ
|  ..|.|| |  .|. ||....|.  .  .||. .     .     ||| |  |        .|.|      .     |..   .     .. .  |.|
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.appstreishyq

WKAWPDRGVPELPMAVFRLLI-R-------LKTASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEK--VVLKDIVKEIRNQRHGSVQTDAQYLFMHR
. .| ..  |.. . |  ..  |        .  .|..|||| | | || .| |.| .          | | .. | .|. | | . .  .| |...
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0049260 (Phosphotyrosine protein) phosphatases II 138-322 2.9e-35 116.6 In-house 8-143 (152) alignment 
Range on Protein: 138-322
Range on HMM: 8-143/152.0
ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWpetadgqmilmdgkltvkiaepakeveqnillmkitviddkgtshnfeHWQW
 ..||.||||.. |..||.|.... .. ..|||.. .| || |||||.                                                ....
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylh

KAWPDRGVPELPMAVFRLLI-----RLKTASPIVVHCSAGIGRTGSIVGLEIALvkfcagEKVVLKDIVKEIRNQRHGSVQTDAQYLFMH
  ||| |||.|.. .  ||.     .|.   |..||||||.|||| .| . . |       .| |...|. .|..| |.|..  |. | .
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 138-187 1.2e-06 22.1 In-house 235-281 (440) alignment 
Range on Protein: 138-187
Range on HMM: 235-281/440.0
ANKFICTQGPTEKTVDDFYRLIWQEKAPCVVMLCNIMecgKKKCEQYWPE
 | ||.|| | . || ||.||. . .   ..|| ..     | |  ||| 
knafiatqmpldstvldfwrlvhdyristiimlnqln...dktcsiywpv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 145-328 3.8e-28 93.3 In-house 39-220 (255) alignment 
Range on Protein: 145-328
Range on HMM: 39-220/255.0
QgptekTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDgkLTVKIAEPAKEVEQNILLMKITVIDdKGTSHNFEHWQWKAWPDRG
      ||| ||. | | |.  |||||.  | |..||..|.|   |....| |  ..|  .... .|    | .  |. . |   |. .|...| |... 
l.....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad..vnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWiekn

VPELPMAVFRLLIRLKTASPIVVHCSAGIGRTGSIVGLEIALVKF------CAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLAL
 |||.  .  .|   . . ..|||||.||||. . |  |..  |.          ..  . ...|.|..|.....|  |  |   ..| |
aPelareilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 146-322 2.6e-23 76.9 In-house 98-281 (302) alignment 
Range on Protein: 146-322
Range on HMM: 98-281/302.0
GPTEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKL-TVKIAEPAKEV--EQNILLMKITVIDDKGTS---HNFEHWQWKA
 |  .|.. .. || | .   || ||...| ..||| .|. .  .|.. .    . ||.. .  .|    ... | .. . ..| ..   .  .  .. |
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDRGVPELPMAVFRLLIRLKT-ASPIVVHCSAGIGRTGSIVGLEIAlVKFCAGEKVV-LKDIVKEIRNQRHGSVQTDAQYLFMH
||| | |. . . . .|   ..    ..||||||.||||..| .    ...|. .||  | .||. .|. |.|.||.. | ... 
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyG.iqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 148-325 1.6e-06 20.9 In-house 127-305 (346) alignment 
Range on Protein: 148-325
Range on HMM: 127-305/346.0
TEKTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETaDGQMilMDGKLTV-----KIAEPAKEVEQNILLmkITVIDD-KGTSHNFEHWQWKAWP
 |  |.||. .|.||.   | ..       .     .  |   |      ||. .      ..   ||   ..|       |      |    |.    |
nesfvedfwymiyqeqihlvylmvpddklkntttslfnden.ggyq..ytgkmfinnrradvsgdpkeytievlp..egnsdsvicqvhhhapwkhlqqp

DRGVPELPMAVFRLL-IRLKTAsPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVL
 . .| . |    |   ....|  . |    | ||. |..|   |. ..  | .  . .|.|.|..|| |.|.. |||  .. ..
pktlpiikmihqflsekqvqna.gvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaiv
subfamily_hpo-7_pd Subfamily hpo-7 150-331 5.4e-25 82.8 In-house 45-229 (263) alignment 
Range on Protein: 150-331
Range on HMM: 45-229/263.0
KTVDDFYRLIWQEKAPCVVMLCNIMECGKKKCEQYWPETADGQMILMDGKLTVKIAEPaKEVEQNILLMKitVIDDKGTSHNFEHWQWKAWPDRGVPELP
.|.| ||. | | |.  |||||.  | |..||..|.|   |....| . ....  .   . . . . |..  ....| . |...|...| |...  |||.
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlells..tlgeKkkthtvkhysykgWiekndpela

MAVFRLLIRLKTASPIVVHCSAGIGRTGSIVGLEIALVK----FCAGE--KVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
  ....|   .   ..|||||.||||. . .  |..  |    .   .  ..    ...|.|..|.....|  |  |   ..| .  |
reilnilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln
0048076 (Phosphotyrosine protein) phosphatases II 226-326 4.8e-20 67.2 In-house 41-140 (145) alignment 
Range on Protein: 226-326
Range on HMM: 41-140/145.0
KGTSHNFEHWQWKAWPDRGVPELPMAVFRLLIRLKTA----SPIVVHCSAGIGRTGSIVGLEIALVkfcagEKVVLKDIVKEIRNQRHGSVQTDAQYLFM
.. ...  ....  |||.|||.|.  . ..|  ...|     |..||||||.||||..|.. . |      ..| | ......|.||.|.|... |. |.
ellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

HRVLL
....|
yefel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 229-326 1.5e-13 44.9 In-house 88-191 (440) alignment 
Range on Protein: 229-326
Range on HMM: 88-191/440.0
SHNFEHWQWKAWPDRGVPELPMAVFRLLIRLK------TASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMH
|. ........|||.|||..   |....  ..        .|..|||||| |||| |. ..  | .    ... .  ... .||.|   |||  || |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

RVLL
 ..|
eavl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 231-323 9.7e-06 19.3 In-house 233-332 (347) alignment 
Range on Protein: 231-323
Range on HMM: 233-332/347.0
NFEHWQWKAWPDRG--VPELPMAVF-----RLLIRLKTASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHR
|   | || .||    |  |  | .      |.  |.  .|.|| |  |. |. ..|   | . .  .|      |. | .|.|| |       | .  |
ncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyair
0048179 (Phosphotyrosine protein) phosphatases II 232-323 2.9e-18 61.4 In-house 49-139 (144) alignment 
Range on Protein: 232-323
Range on HMM: 49-139/144.0
FEHWQWKAWPDRGVPELPMAVFRLLIRLKTA----SPIVVHCSAGIGRTGSIVGLEIALvkfcaGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHR
  ....  |||.|||.|.  . ..|  ...|     |..||||||.||||..| . . .      ... |.......|..| |.|... |. |...
giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
PTPc_DSPc_SM00012 234-326 2.1e-28 94.0 In-house 4-104 (105) alignment 
Range on Protein: 234-326
Range on HMM: 4-104/105.0
HWQWKAWPDRGVPELPMAVFRLLIRLKT--A-----SPIVVHCSAGIGRTGSIVGLEIALVKFCAG-EKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVL
| ....||| |||| . ....||  .|.        .|.|||||||.|||| .| |.|.| ..... ..| ...||||.|.||.|.|||..||||..|.|
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral

L
|
l
PTEN_1 240-318 2.9e-06 22.2 In-house 102-182 (196) alignment 
Range on Protein: 240-318
Range on HMM: 102-182/196.0
WPDRGVPELPMAVF--RLLIRL-KTAS---PIVVHCSAGIGRTGSIVgleIALVKFCAGekVVLKDIVKEIRNQR-HGSVQTDAQY
..| |.| | .     . .|   . ..    ..||| ||.||.| .|   .|.  .. .     .. .. .| .| .|....  | 
ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv...aayLmykgk..ltadeAlelvrekRppgapnspsqe
0038934 (Phosphotyrosine protein) phosphatases II 241-321 1.9e-07 26.4 In-house 88-169 (194) alignment 
Range on Protein: 241-321
Range on HMM: 88-169/194.0
PDR-GVPELP-----MAVFRLLIRLKTASPIVVHCSAGIGRTGSIVGLeiALVKFCageKVVLKDIVKEIRNQRHGSVQTDAQYLFM
||.  || |      . .    .. ..   ..||| ||.|||| .|.   .|.. .   .  ... .. .|  | |....  ..  .
pddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa..YLiyrl...gmsaeeAialfrekRpgaipnqdyleal
subfamily_CDC14_pd Subfamily CDC14 241-320 1.4e-06 22.4 In-house 242-317 (328) alignment 
Range on Protein: 241-320
Range on HMM: 242-317/328.0
PDRGVPELPMAVFRLLIRLKTASPIVVHCSAGIGRTGSIVGLEI-ALVKFCAGEKVVLkdivkeIRNQRHGSVQTDAQ-YLF
 | ..|.  .    | |  |.   |.||| ||.||||....  .    .| | | .        .|  | ||| .  | .| 
iDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiaw......lricrPGsvigpqqkfle
subfamily_PRL_pd Subfamily PRL 259-315 5.1e-06 20.6 In-house 87-137 (151) alignment 
Range on Protein: 259-315
Range on HMM: 87-137/151.0
LKTASPIVVHCSAGIGRTGSIVGleIALVKfcAGEKvvLKDIVKEIRNQRHGSVQTD
 .. | . ||| ||.||.  .|   .||.   || |   .| |. ||..|.|.. . 
eepkstvavhcvaGlGraPvlva..lalie..aGmk..yedavefirekrrgainsk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 260-329 3e-09 31.1 In-house 260-344 (350) alignment 
Range on Protein: 260-329
Range on HMM: 260-344/350.0
KTASPIVVHCSAGIGRTGSIVGLEIALVKF---------------CAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
. .|||.||||||.|||| .| |.  | .|                |  . ... ||.|.|.||   ||.  |..|..  || . 
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 260-291 5.8e-07 23.1 In-house 263-294 (349) alignment 
Range on Protein: 260-291
Range on HMM: 263-294/349.0
KTASPIVVHCSAGIGRTGSIVGLEIALVKFCA
.  |...|||||| |||| .| |.. |  .  
dqlstllvhcsaGcGrtGvlvtldlllsilep
subfamily_CG42327_pd Subfamily CG42327 262-329 5.3e-13 43.3 In-house 247-315 (319) alignment 
Range on Protein: 262-329
Range on HMM: 247-315/319.0
ASPIVVHCSAGIGRTGSIVGLEIALVKFCAG-EKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALA
  |.||||| |.|||| ..  .||. ..    . | . ..|  .|..|  .|.|  || |...||   |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 262-327 7.3e-11 36.5 In-house 228-293 (297) alignment 
Range on Protein: 262-327
Range on HMM: 228-293/297.0
ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLA
  ...||||||.||.| .|  .. | |   .     . |.. .|.||   |||  |. ... . |.
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPDC1_pd Subfamily PTPDC1 262-334 5.1e-08 27.6 In-house 114-181 (182) alignment 
Range on Protein: 262-334
Range on HMM: 114-181/182.0
ASPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKvvlkdIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKI
   . ||| || |||| ..   .  .|  ..||      .| .|..|  |.||  |  ...   | |.. ||.
egkvavhChaGlGrtGvliacylvyakrltaek.....aiklvrskrpksiqtreqvelvkefalfliplrkv
subfamily_PTPN9_pd Subfamily PTPN9 263-331 8.7e-19 62.6 In-house 224-292 (297) alignment 
Range on Protein: 263-331
Range on HMM: 224-292/297.0
SPIVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAEN
 ||||||||||||||  . |.|.| ..   ..| . . || .|.||  |.||. || | .  .|  | .
PPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 265-326 1.7e-07 25.5 In-house 1-62 (69) alignment 
Range on Protein: 265-326
Range on HMM: 1-62/69.0
IVVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
.|||||.| ||||... . . . .  .   | . . |. .|  |   |  . .|.|.|  | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_DSP23_pd Subfamily DSP23 265-317 1.1e-06 23.3 In-house 87-134 (148) alignment 
Range on Protein: 265-317
Range on HMM: 87-134/148.0
IVVHCSAGIGRTGSIVGleIALVKFcagEKVVLKDIVKEIRNQRHGSVQTDAQ
. |||  | ||||...     |||    .|.   . . |.|..| |||.|  |
vsvhcllgrgrtgtmla..cylvke...rklaaaeaiaevrrlrpgsvetveq
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 266-326 5e-07 24.0 In-house 1-61 (69) alignment 
Range on Protein: 266-326
Range on HMM: 1-61/69.0
VVHCSAGIGRTGSIVGLEIALVKFCAGEKVVLKDIVKEIRNQRHGSVQTDAQYLFMHRVLL
|||||.| ||||. . . . . .  .   | . . |. .|  |   |  . .|.|.|  | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalv
RasGAP_C RasGAP C-terminus 296-340 6.4e-06 12.3 Pfam-A 31-75 (142) alignment 
Range on Protein: 296-340
Range on HMM: 31-75/142.0
VLKDIVKEIRNQRHGSVQTDAQYLFMHRVLLALAENRKITSPELS
.|..| |.|||.|. . .....   ....| .| | .|. . .| 
llneIakdIrnkrrlrekrkkElkkleqtlkkLreknkyleeqld