Gene T28F4.3 in Caenorhabditis elegans

Synonym: CELE_T28F4.3, T28F4.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf15
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP190_AA protein Get Run
CeleP190_AA_44-315 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 34-313 1.1e-31 104.6 In-house 4-289 (310) alignment 
Range on Protein: 34-313
Range on HMM: 4-289/310.0
DDAEKKSEKSSNCMIWSQNvlkKAKISNMTREFRN-NKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLK-ERDPSNDYIHASWMVMPD-GFQFISTQ
||  .|  |. . .| . .   |  |  .....|. . .  . .|    .| | ||||  . | |. || || ..   .||||| ..        || .|
ddhhlkylkalenfiiate...klgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsq

GPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTS-EKEYGDYRVKVVEKTVELWNPV--KVT----GIQVQKKNCPTKHM-VYHYFYYDW
||.. || ||| |.. |..  |..||.  || . ||  |.      . ||  ||  . .. | .. .   ||     . |... .  |.. |    . .|
gplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnw

HDQVAPLDPAPMIkmYKAVLNKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
 |.  | .    .   . .| .    | |||||||..|. . | . |.   ...   ||. |.   |.  |.  .|..|||...  ..| .
pdrgvpdekchtv..pqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
0039614 (Phosphotyrosine protein) phosphatases II 39-314 2.3e-72 239.3 In-house 11-289 (297) alignment 
Range on Protein: 39-314
Range on HMM: 11-289/297.0
KSEKSSNCMIWSQNVLKKAKISNMTREFRNNKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPS---NDYIHASWMVMPD--GFQFISTQGPI
 . .. ... . . ..|. ... . .|| . ...||. ... ... .|||||..|.. |..||.||  | .   .|||.||.. ..|  . .|| |||| 
sipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

KNTIADFWHMVYTEKCHVIVMLCQYIEEDQeKCQRYFSDTSEkEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPtkHMVYHYFYYDWHDQVAPLDPAP
..|..|||.||. ....|||||.. .| .. ||..|...... .|||..|.... ..   . ..|. . |......  ..|.|. |..| |  .| ... 
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh..ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslel

MIKMYKAVLNKS----SSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
.......| .      ...|..|||||||||| ||...||   .....  ||. |..|.|| .| ||||.  ||..|  ...||.
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 39-311 7e-52 171.5 In-house 6-287 (298) alignment 
Range on Protein: 39-311
Range on HMM: 6-287/298.0
KSEKSSNCMIWSQNVLKKAKISNMTREFRNNKEYKP---NVTTSISEK--MMDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMPDG-FQFISTQ
..|. .. .   ..| || |..... ||.. .. .    . ......|    .||||  |   |  ||||..   |   ||| ||..   .|   || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

GPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLD
.|...|..|||.||  |.  .|||| .  | |. |...|. |. ...||. .|.. .| .     . |. ..|.||.  ....| .  .  | |. .|  
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeef..adlivrklkvskkkeekerevrqlhftsWpdkgvpen

PAPMIKMYKAVL-NKSSS--KPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMI
   .... . |  ... .  ||..|.|||||||. ||. |.     ......||. ...|.||. | ||||.. |||..  ...
atsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
0045450 (Phosphotyrosine protein) phosphatases II 46-315 3.2e-72 239.2 In-house 13-305 (307) alignment 
Range on Protein: 46-315
Range on HMM: 13-305/307.0
CMIWSQNVLKKAKISNMTREFRNNKEYKP----NVTTSISEKMMDKNRYRHIFCGDDNRVVLKERD---PSNDYIHASWMVMP---------DGFQFIST
.... ...|..  .. . .||.  .....    . ... ... .|||||..|.. |..||.|.  |   ...|||.||.. .|          . .|| |
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDT-SEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKK-NCPTKHMVYHYFYYDWHDQVA
||| ..|..|||.|.. ....|||||.. .| ..||| .|..|. .|..||...|.......  .. ..|. . |. .  .   ..|.|..|..| |. .
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

PLDPAPMIKMYKAVLN----KSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSS---VDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
| ...........|..     ....|..|||||||||| ||...||   .....     ||. |..|.|| .| ||||.. ||..|  ...||. 
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 47-323 2.6e-25 83.6 In-house 10-288 (303) alignment 
Range on Protein: 47-323
Range on HMM: 10-288/303.0
MIWSQNVLKK-AKISnmTREFRNNKEYK-PNVTTSISEKMMDKNRYRHIFCGDDNRVVLKErdpsNDYIHASWMVMPDGFQFISTQGPIKNTIADFWHMV
.  ....|.. |.|.  . || .   |  |.|.     | |||||.  . | |  .| | .      |||||.. .    . | || |.  | |||| |.
kllakrtldedania..vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd....ssyihasyleldsskkailtqlplshtaadfwqmi

YTEKCHVIVMLCQYIEEDQEKCQRYFSDTSE-KEYGDYRVKVVE-KTVELWNPVKVTGIQVQkkNCPTKHMVYHYFYYDWHDQVAPLDPAPM----IKMY
  .| .....|    | |.   .  |    .  .. .  ..| | | ||| .  ..  . |   |   | ... . | .|  .  | | .|     |   
ieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvs..ngdyksflhvhhykawphnsipsdgspkfvkqiwql

KAVLNK-SSSKPIVVHCSAGVGRTSTFVGIYLSQIMI-RENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRN
..|| | | |.| |    .|.||. ||  .  ... .  |..|.|.|  |. .|  || |||   |. ..  |. |  .|. |.|  
qsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickla
0036941 (Phosphotyrosine protein) phosphatases II 48-316 2.6e-76 252.1 In-house 4-279 (297) alignment 
Range on Protein: 48-316
Range on HMM: 4-279/297.0
IWSQNVLKKAKISNMTREFRNNKEyKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLkeRDPSNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYT
... . | .|...   .|. ...   .. ....... ..||||..|.. |..||.|   |...|||.||.. ..| ...|| |||| .||..|||.||. 
kllekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

EKCHVIVMLCQYIEEDQEKCQRYFSDT--SEKEYGDYRVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK
....|||||....| . |||..|....  ....|||..|.... .| | . .... ..|...... ...|.|. | .| |  .| .||........|...
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

S----SSKPIVVHCSAGVGRTSTFVGIYLSQIMIR---ENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFID
     |..|..|||||||||. ||....|   ...   ..  ||..|..| ||..| ||||.  ||..|  ...||.  
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 48-315 1.1e-39 131.2 In-house 8-272 (288) alignment 
Range on Protein: 48-315
Range on HMM: 8-272/288.0
IWSQNVLKKAkISNMTREFRNNKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKerDPSNDYIHASWMVMP-DGFQFISTQGPIKNTIADFWHMVYT
 | . ||. | .  . .|.|.  .  .. . .   .   ..||..... |  || |.  | .. ||.|  .       ..| .| |.. ||  .|.|. .
awirlvlqia.veglkkeyrdspneasidiidsfianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmlle

EKCHVIVMLCQYIEEDQEKCQRYFSDTS--EKEYGDYRVKVVEKTVELWNPVKVTGIQVQKkNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVlnK
.  . |||||. .|  .|| . ||      .  .| .   | .| ...   |||. ....| .  .| .| .  . .| |.  | .  . ... . .  |
sdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllrisk.egeekvivkilhlleWdddgvPenylsplrllevl..k

SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
|  ||||||.||||||| |.. | .   ..| .  . . ..|..||  |  |.|.. ||.|.  .. | ..
slqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 49-329 2.7e-47 156.3 In-house 6-288 (307) alignment 
Range on Protein: 49-329
Range on HMM: 6-288/307.0
WSQNVLKKAkISNMTREFRNNKEYKPN-VTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPSNDYIHASWMVM-PDGFQFISTQGPIKNTIADFWHMVYT
| |. |.|  ..... |||.  ...|. ||.   .   |||||. . | | .|.|.|    . ||||| .. .  .  .|| .||| .||. .|| |.  
wvqrtldkg.vqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiq

EKCHVIVMLCQYIEEDQEKCQRYFSDT--SEKEYGDY--RVKVVEKTVELWNP----VKVTGIQVQKKNcpTKHMVYHYFYYDWHDQVAPLDPAPMIKMY
||   ..|||. ||  . ||..|.      .. .|.    . | .  ..   |    ..|| ..|.  .      . |. . .| |. .|      | . 
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaq..ksrtiqhlqwenwpdrgvpqinltainll

KAVlnKSSSKPIVVHCSAGVGRTSTFVGI-YLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDdkiiKRNANYESL
.||  .    |.||||||||||. | |.| .. . ||.     || .... ||. |  |.|...||.||  ...| |..    .    || |
eav..rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle....lyketyeel
0050432 (Phosphotyrosine protein) phosphatases II 50-314 6.2e-78 257.5 In-house 32-299 (308) alignment 
Range on Protein: 50-314
Range on HMM: 32-299/308.0
SQNVLKKAKISNMTREFRNNKEYKPNVT--TSISEKMMDKNRYRHIFCGDDNRVVLkerDPSNDYIHASWMVMP---DGFQFISTQGPIKNTIADFWHMV
 . . |.  .... .||.   ..||. .  ..  .. .|||||..|.. | .||.|   |...|||.||.. ..      .|| |||| .||..|||.||
lkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

YTEKCHVIVMLCQYIEEDQEKCQRYFSDT---SEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV
. ....|||||.. .| ..||| .|. ..   . .|||...|.... .|   . ..|. .........  ..|.|. | .| |. .| .|.........|
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

LNKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
 .. ...||||||||||||| ||. ..|   .....  ||. |..|.||..| |.||.  ||..|  ...|..
rkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 50-323 9.9e-40 131.2 In-house 13-296 (305) alignment 
Range on Protein: 50-323
Range on HMM: 13-296/305.0
SQNVLKKAKIsNMTREFRNNKEYKP--NVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPsNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYT
 ...|.|. .  .  || . | ..    . .    .  .||||. . | |.||| |.   |  .|||| ..  |    .|| || |...| ||||.| . 
vkrtlekgpa.glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwp.heyihanyvstptnpkrfictqaplektcadfwymclq

EKCHVIVMLCQYIEEDQEKCQRYFSDTS----EKEYGDYRVKVV-E--KTVELWN----PVKVTGIQVQKKNCPtKHMVYHYFYYDWHDQVAPLDPAPMI
.| . | |||...|   .||. ||.       | | .. .. |  |  .|... .     |. | . ..   .  .. | || . || |.  |     ..
dkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwpdrgvpaadlail

KMYKAvlNKSSSKPIVVHCSAGVGRTSTFVGI-YLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRN
.. .    ..|  |||||||||.||| . | . |. . ..  .   |   ||...|  |  ..|.. ||...  .... | . |... .
ellek..arpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee
subfamily_PTPN6_pd Subfamily PTPN6 51-316 3.4e-49 162.5 In-house 20-298 (306) alignment 
Range on Protein: 51-316
Range on HMM: 20-298/306.0
QNVLKKAKISNMTREFRN-NKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKER-DPSNDYIHASWMV---MPDGFQFISTQGPIKNTIADFWHMVY
.. |.|| ....  |... ..... . . .   . . ||||. |.  |..||.|||   | .||| |. .         ..|.||| ...|..|||.||.
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

TEKCHVIVMLCQYIEEDQEKCQRYFSDTS-EKEYGDYRVKVVEKTVElwNPVKVTGIQVQ-KKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN
 |...||||. . .|  .||| ||. |.. ..|||...|. |...    .  ..  ..|. ||.  ... |..| . .| |.  | ||  .... . | .
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksl..adYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

KS------SSKPIVVHCSAGVGRTSTFVGI--YLSQIMIRE-NSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVlMIELFID
|.      .. |||||||||.||| ||. |   |..|. .  .  .|. .. | .|. | | || . || ..   .|. .|.
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyk.aikkyie
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 52-321 6e-26 85.6 In-house 18-291 (302) alignment 
Range on Protein: 52-321
Range on HMM: 18-291/302.0
NVLKKAKISNMTREFRNNKEYKPNVTT-SISEKMMDKNRYRHIFCGDDNRVVLKERdpSNDYIHASWMVMPD-GFQFISTQGPIKNTI---ADFWHMVYT
.. |. . .....|| . .. | ..   ..  | ..||.  .. . |.|.| |...   ..|..|| . .|. . . | .| |....    ..||.||. 
klvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleae..pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

EKCHVIVMLCQYIEEDQeKCQRYFSDTSE--KEYGDYRVKVveKTVELWNPVK-VTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV--
||.  .|.| .  | ..   . .|  .|.  ||||. .| .  . ||  .  |    | |  ..|    ..  |    |...  |   | .||  . |  
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNn..rkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfa

LNKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMiELFIDDKIIK
.. ......|.    |.|| ..|.   ..   . ... . . ||.| .|. |  ||.|  ||| | . .  |.|  |. |
kkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial.llyikkkvtk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 54-310 1.3e-41 137.4 In-house 19-277 (301) alignment 
Range on Protein: 54-310
Range on HMM: 19-277/301.0
LKKAKISNMTREFRNNKEY-KPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKeRDPSNDYIHASWMVMP-DGFQFISTQGPIKNTIADFWHMVYTEKCHV
 | ||. | | |  |     | ..| | .    ||.|| .. |  .  | .   |     ||| |.  . .  .||.||||.|||  ||| |.   . . 
dktakfynttienvnvttidkdhitesyaylpkdkhryptvPckPstavevi.vdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvek

IVMLCQYIEEDQEKCQRYFSDTSEK--EYGDYRVKVVEKTVELWNPVKVTGIQVQKK--NCPTKhMVYHYFYYDWHDQVAPLDPAPMIKMYKavLNKSSS
||||.| .|. .|||. |.. . ..  . | ...|...| . | . ..   ..|.    . .|.  | || | .| |.  |   | . .. .  | | | 
ivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatr.tvthyqysewtdrgvPkshaelfdlme..lvkkse

KPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
||||||||||.||. .|.|       .  .  ... | ||.||  |  .|| . |  .. .  
kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGt
subfamily_PTPRD_pd Subfamily PTPRD 55-382 1.2e-62 207.4 In-house 18-348 (564) alignment 
Range on Protein: 55-382
Range on HMM: 18-348/564.0
KKAKISNMTREFRNNKEYkPNVTTSISEKMM--DKNRYRHIFCGDDNRVVLK--ERDPSNDYIHASWMvmpDGF----QFISTQGPIKNTIADFWHMVYT
|. .  ....|... .|  ...|.. ..| .   |||| .|   | .||||.  | |.. ||| ||..   ||.    ..| ||||...||.||| ||. 
kansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfi...dgyrkrkayIAtqgPlaetiedFWRmvwe

EKCHVIVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVL--NK
.....|||| .  |....||..|. ......||.. |...|..    . . .. ....||.   ...| .. . .| |. .|  ....... . |   |.
qnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee..ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne

SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRNANYESLLKKYADVTRKVTAAI
. ..||||||||||||| ||. |      |.|.  ||. ...|.||. |   ||.. ||...   . |     .   .  |... |.| | |... . . 
pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaeveedtemtg

MEEEEKRRQRKKREEEKEKeQEKESPATKEEKKKENGL
.| | .| .  |..| .|. .  . |  |.  .  | |
leleFqrLatakeieleef.avatkpknkkknrfsnil
subfamily_PTPRK_pd Subfamily PTPRK 55-313 8.4e-45 147.9 In-house 17-276 (314) alignment 
Range on Protein: 55-313
Range on HMM: 17-276/314.0
KKAKISNMTREFRNNKEYkpnVTTSISEKMMDKNRYRHIFCGDDNRVVLK--ERDPSNDYIHASWMvmpDGF----QFISTQGPIKNTIADFWHMVYTEK
|.|.   . .|. .  |      ..  ..  .|||. .|   |  ||.|.  . |||.||| |...   |..    .|| ||||...|..||| .|| |.
kraegygfkeeyeslfeg...wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali...dsykrpaafivtqgPlqetvkdfWrlvyden

CHVIVMLCQYIEEDQEKCQRYFSDTSEKeYGDYRVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN--KSS
|  |||| . .|. . || .|. . .|. ||| .|..|| ...    |..  ..  ...   ...| .. .  | |   |     ..|. . | .  . .
casivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeee

SKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
  .|||||||| ||| ||. |     ||.... ||. .. | ||. .   |. . ||...   ..| 
aGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_PTPN9_pd Subfamily PTPN9 55-313 1.1e-44 147.7 In-house 11-289 (297) alignment 
Range on Protein: 55-313
Range on HMM: 11-289/297.0
KKAKISNMTREFRNNKEYKPNVTTSIS--EKMMDKNRYRHIFCGDDNRVVLKER--DPSNDYIHASWMvmpDGFQ----FISTQGPIKNTIADFWHMVYT
|. ... ...|. . .. ... |   |     . ||||  . | |. ||||...  |.  |||.|...   ||..    ||.||||.|.|. ||| ||. 
kekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfv...dGykqkkafiatqGplkktvsdfWrmvWe

EKCHVIVMLCQYIEEDQEKCQRYFS--DTSEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK
... ||||  . .|. . ||..|.   . | .|.||..|..||  .|  .  ||. ..... .   .  | |. .  | |   | . | .... ..| .|
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveee..edykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek

SS---------------SKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
 .                 |||||||||.||| ||. . ..   ..| . ||.|| .|.||| |  ..| . ||..  . ..| 
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0051299 (Phosphotyrosine protein) phosphatases II 56-313 6.7e-73 241.0 In-house 19-285 (288) alignment 
Range on Protein: 56-313
Range on HMM: 19-285/288.0
KAKISNMTREFRNNKEYKPN--VTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMVM-PDGFQFISTQGPIKNTIADFWHMVYTEKCH
.  .... .||.   ...|.  ..... .. ..||||..|.. |..||.|.  |  ...|||.||.. . . . .|| |||| .||..|||.||. ....
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

VIVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKK----NCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--
|||||.. .| ..||| .|... . ..|||..|. .. .|  .. ..|. ..|...     . ....|.|. |..| |. .| .| ........| ..  
vIvmltklvelgrekcaqYwplggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
|...|.||||||||||| ||. ..|   .....  ||. |..||||..| |.||.  ||...  ...|.
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0047943 (Phosphotyrosine protein) phosphatases II 56-313 1.2e-71 236.7 In-house 8-271 (273) alignment 
Range on Protein: 56-313
Range on HMM: 8-271/273.0
KAKISNMTREFRNNKEYKPNV--TTSISEKMMDKNRYRHIFCGDDNRVVLkeRDPSNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVI
.  .. . .||.  ...||..  .... .. .|||||..|.. |..||.|   |...|||.||.. ... . .|| |||| .||..|||.||. ....||
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMLCQYIEEDQEKCQRYFSDTS---EKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS----
|||.. .| ..||| .|....    ...||...|.... ..   . ..|. ......... ...|.|. |..| |. .| ...........| ..     
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

SSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
|..|.||||||||||| ||. ..|   .....  ||. |..|.||..| |.||.  ||..|  ...|.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 56-312 4.4e-43 142.3 In-house 15-275 (315) alignment 
Range on Protein: 56-312
Range on HMM: 15-275/315.0
KAKISNMTREFRNNKEYKPNVTTSISEK-MMDKNRYRHIFCGDDNRVVL--KERDPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHV
. . . ...||..  . ..  ...  |.  . ||||. |.  | .||.|   . .| .||| || .   |    .|..||| | .. |||.||. ||   
nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtt

IVMLCQYIEEDQEKCQRYFSD--TSEKEYGDYRVKVVEKTvelwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVL--NKSSS
|||. .  |.|. ||..|. |  .   |.| ..|....           .  ..  ..  ... |  . . .| |. .. . . ..|. |.|   |..  
ivmvtkkqegdkikcrqywPdrkadsvefGsikvellsle....adtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkke

KPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
 ...||||||||||  .. |      |....|||. ...| ||. |   ||.. .| ..   . |
fsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 56-319 1.7e-35 117.0 In-house 7-274 (281) alignment 
Range on Protein: 56-319
Range on HMM: 7-274/281.0
KAKISNMTREFRNNKEYKPN-VTTSISEKM-MDKNRYRHIFCGDDNRVVLKER---DPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKC
|  . .. .|| |     |  . | . . .   ||||  | | |  || || .     | ||||| ..  |     .| |||| |.| ||||.|.. |. 
kmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqent

HVIVMLCQYIEEDQEKCQRYFSDTSEK--EYGDYRVKVVEKTVelwNPVKVT-GIQVQkKNCPTkHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKss
  ||||||..| ..|||  ||   .    ..  . |.  . ||   |   ||  ...   .  | ... |... .| |   |     |.|. . .  .  
taivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstv...nkslvttrlnls.yeget.rlithwlwkewpdwqvpessevmlkilrkirar..

SKPIVVHCSAGVGRTSTFVGIYLSQIMIREN-SSVDMVEILKRLR-TMRLGAVQSQLQYVYLVVLMIELFIDDKI
| | |.||||||||. |.. . ..   |.   .  |. .|. .|| | |  .||.  ||. .  ..... .  | 
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykq
0040438 (Phosphotyrosine protein) phosphatases II 58-314 3.1e-75 248.7 In-house 19-276 (317) alignment 
Range on Protein: 58-314
Range on HMM: 19-276/317.0
KISNMTREFRNNKEYkpNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDP--SNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVM
....  ......| .  . .... .. .|||||..|.. |..||.|.  ..  ..|||.||.. .|. . .|| |||| .||..|||.||. ....||||
alleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--SSSKPIVV
|..  | ..|||..|... ....|||..|.... ..   . .... ..|..........|.|. | .| |. .| .| ..... .|| ..  ....|..|
LteleelgrekcaqYwplgetltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlV

HCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
||||||||| ||...||   .....  ||. |..|.|| .| ||||.  ||..|  ...|..
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_PTPN12_pd Subfamily PTPN12 58-315 3.5e-52 172.1 In-house 16-278 (290) alignment 
Range on Protein: 58-315
Range on HMM: 16-278/290.0
KISNMTREFRNNKEYKPNVTTsiSEKMMDKNRYRHIFCGDDNRVVLKERDPSN--DYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVM
|. .........|.|. ....  .|. . ||||. |.  | .||.|.. . ..  ||| |...  ..|  ..|..|||. .|. |||.|..  . ...||
klkklsekykaekvysteage..keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvm

LCQYIEEDQEKCQRYFSDTSEKE--YGDYRVKVVEKTVeLWNPVKVTGIQVQKKncPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVL--NKSSSKPI
.|. .| .. ||.||.... |.|  .|...|.. |.   . .   .  ..|...   ....|| . | .| |.  |  . ..... ..|   ..|...|.
aCrevelgkkkCerYWpeegeeelefgefevtleeeka.vdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPl

VVHCSAGVGRTSTFVGIYLSQ-IMIRENS--SVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
||||||||||| | . | . . .. .|.   ..|. ... .||. |  .||.. ||...   ..||. 
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 59-311 2.2e-51 169.8 In-house 22-280 (319) alignment 
Range on Protein: 59-311
Range on HMM: 22-280/319.0
ISNMTREFRNNKEYKPN-VTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMvmpDGF----QFISTQGPIKNTIADFWHMVYTEKCHV
   . .||.. || ... ....  |.  .||||. |   |  ||||.| |  .. ||| ||..   ||.    .||.||.|..||| ||| ||. |....
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfi...dgyqerekfiatqaPlentiedfWrmvWeeessi

IVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKtvELWNPVKVTGIQVQKKNCPT-KHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS---SS
.|||..  |. . |...|....  .||| . |.. |.  |  . . .  ....||.      .| |. | .| |.  | .   .....| . .     .|
vvmltklveklkvklkkywpeenfeeyGrlivtleee..eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqs

KPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMI
.||||||||||||| ||. .      ..|.. .|. .. .|||| |   || . || ..   ..
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeall
subfamily_PTPN23_pd Subfamily PTPN23 59-309 2.7e-46 152.7 In-house 17-277 (288) alignment 
Range on Protein: 59-309
Range on HMM: 17-277/288.0
ISNMTREFRNNKEYK-PNVTTSISEKMMDKNRYRHIFCGDDNRVVLKerDPSNDYIHASWM--VMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVML
. .  .|...... .  . ...|.... .|||.| |.  | |||.|.  .  .||| ||..  . |   .|| ||.|...|..||| ||| .|  |||||
ldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVml

CQYIEEDQEKCQRYFSDTSE--KEYGDYRVKVVEKTveLWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN------KSSS
 .  | ...|..||.    .  ...||..| . ...    ...    .... ..  ....| |  .  | .  .|  |  .... ..| .      . | 
lskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr..etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksk

KPIVVHCSAGVGRTSTFVGIYLSQIMIR-ENSSVDMVEILKRLRTMRLGAVQSQLQY--VYLVVL
.|.||||||||||| .|  .|   . .. .|  .|......|||. |   || . |.  .| .||
tPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 59-339 2.1e-33 110.4 In-house 18-302 (312) alignment 
Range on Protein: 59-339
Range on HMM: 18-302/312.0
ISNMTREFRNNKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERdpSNDYIHASWMVMPDGFQ-FISTQGPIKNTIADFWHMVYTEKCHVIVMLCQ
  ..|.|..   .  ..   .   |. | |||  | | |  |  |      | |||| .. .    . |..||||..||.. ||... .  .  |..|| 
pqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagd..enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

YIEEDQEKCQRYFSDTSE-KEYGDYRVKVVEKT-VEL--WNPVKVT--GIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVlnKSSSKPIV
..|.  ||| .| ||     .  |.||     | .|.      |.|   ..|  |    .  . || .  | |.  |       ..  ||  |   ||..
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav..kkdkkpvi

VHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRNANYE-SLLKKYADVTRK
 ||||||||| |.. |      .|     .. ...  ||  |  .|.   |||| .  ..|..    . ||| .    . . || .  |
ahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyakikak
subfamily_ptpA1_pd Subfamily ptpA1 59-267 1.5e-27 91.4 In-house 20-249 (418) alignment 
Range on Protein: 59-267
Range on HMM: 20-249/418.0
ISNMTREFRNNKEYKPNVTTSISEKM--MDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMVMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVM
| ..  |||  .|      ||  .|     ||||  |.  .  || ||. .    .||| | ..      ||| ||||. |||||||.||. ..|..|||
ihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivm

LCQYIEEDQEKCQRYFSDTSEK-----------EYGDYRVKVVEKTVELWNPVKVTGIQVQKkNCPTKHmVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN
| .  |. . ||.||. .                .| | |..||   .    .    |..   .  |.  . .| |  | |.  |    |. .. ... |
lsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf.egetrd.itqyqyegwpdhnipdhtqpfrqllhsitn

KS------S--SKPIVVHCSAGVGRTSTFVGI
.       |    ||.|||||||||| ||.  
rqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 60-315 1.8e-53 176.5 In-house 21-280 (288) alignment 
Range on Protein: 60-315
Range on HMM: 21-280/288.0
SNMTREFRNN--KEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVM
.....|...    | . .||..   .  .||||| |   | .|| ||.    ...||| ||..   ..  ..|.||||. .|. |||..|| .| . |||
tgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivm

LCQYIEEDQEKCQRYFSDTSE-KEYGDYRVKVVEKTvELWNPVkVTGIQVQKKNcpTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--SSSKPIV
| . .|....||..|. |. . |.||.  |..||.  || . | .  . ..||.  |.  . .| |  | |.  | . ||.... . | .   . ..||.
ltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfv.lrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpii

VHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
|||||||||| ||. .     ...|.  .|.......||  |   || . ||...   ...|  
vhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Ptp69D_pd Subfamily Ptp69D 60-315 1.1e-46 154.4 In-house 22-287 (307) alignment 
Range on Protein: 60-315
Range on HMM: 22-287/307.0
SNMTREFRNNKEYKPNVTTSISEKM--MDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMP-DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVM
  ...|... .. . . .|..|||     |||| .|   |..||.||.   . . ||| ||..    . ..||  |.|. .|| ||| |.   . ..|||
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

LCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVELW---NPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV--LNKSSSKP
| .  | ...||..|...  |..|||  ||.|..          ..|. .. .  . . .. |  | |  |.|  .|  .  ..|. . |  |.| .  |
lsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsP

IVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
|||||||||||...|| . .    .... .||..|. | ||  |   |||  |||.|   ...   
ivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 60-318 2.5e-43 143.6 In-house 34-297 (319) alignment 
Range on Protein: 60-318
Range on HMM: 34-297/319.0
SNMTREFRNNKEYKPNVTTSI---SEKMMDKNRYRHIFCGDDNRVVLKERDP--SNDYIHASWMVM-PDGFQFISTQGPIKNTIADFWHMVYTEKCHVIV
...  |||.  .  .| ..      ..  ||||. .|.  | |.| |.  .     ||| ||..       ..|..||| .||.|||| |..  .|  ||
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLCqyieedQEKCQRYFSDTSEKEYGDYRVKV--VEKTVElwnpVKVTGIQVQKK-NCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV---L-NKSS
.|       ..|| .|.    ..... . |||  ||.| |      |  |.. .. .   .  .  . .  | |.  |  |...... | |      .  
llt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh

SKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE--LFIDDK
 ..|||||||||||| ... .     ...|.. ||. .... ||  |   ||.  || .. . ..|  ||    
ranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsd
subfamily_PTPRN_pd Subfamily PTPRN 60-308 2.5e-38 126.5 In-house 29-286 (297) alignment 
Range on Protein: 60-308
Range on HMM: 29-286/297.0
SNMTREFRNNKEYKPNVTT---SISEKMMDKNRYRHIFCGDDNRVVLKERDP--SNDYIHASWMVMPDG--FQFISTQGPIKNTIADFWHMVYTEKCHVI
... .|.   ..|. . .|   . .||...|||.....  |..|| |||.    ..||| || ..  |     .|.||||. .|.|||| ||. . . ||
drlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvi

VMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVelW-NPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVlNKS---SSK
|.|..  ||. ..|.||. |. .. |. | |..| . .  | .   |  . ..  .      |  . .  |... .|  . ..... . | |||    | 
vnltrleeegvkqckrywpdeGsevyhiyevhlvsehi..wcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkv.nksyrGrsc

PIVVHCSAGVGRTSTFVGIYL-SQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVV
|||||||.|.||| ... | |  . ...    .|..  |. ||  | | |... |. . . 
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
subfamily_PTPN13_pd Subfamily PTPN13 61-312 4.1e-51 168.8 In-house 12-267 (273) alignment 
Range on Protein: 61-312
Range on HMM: 12-267/273.0
NMTREFRNNKEYKPNVTTSISEK--MMDKNRYRHIFCGDDNRVVLKERDPsndYIHASWM---VMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVML
. . ||.. .| ||  |.....|   .||||||...  |. || |..  .   || ||..   |  | ...| .|||. .|..||| ||.  |..||.|.
qPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

CQYIEEDQEKCQRYFSDTSEKEYGDY-RVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK-SSSKPIVVH
 .  |... ||.||. .. .|.   . |..|    |.  .  .|  ..|....    . | |  . .| |   |  .|..... . | .  ... |||||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvh

CSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
||||.||. |.. |.    .|  . ..|. ||...||  | | ||.. ||..    ..|
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 61-323 2.3e-50 166.5 In-house 23-294 (305) alignment 
Range on Protein: 61-323
Range on HMM: 23-294/305.0
NMTREFRNNKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPSN--DYIHASWMVMP-DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQ
..  ....  | .  .    .|.   |||...|.  ||.|. |.|..  .  ||| ||..       ..| .|||.|||.||||.... || ..||||..
gleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

YIEEDQEKCQRYFSDTSEK--EYGDYRVKVVEKTVElwNPVKVTGIQVQK-KNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSSSK---PIV
 .|....||..|. ..  .  |.|.. |.. ...    .      ... . ..   .. | .|   || |.  |  .. .....| | .. ..    |..
lveggkdkCrqYWpesktekkefgefsvelksekta..sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDK--IIKRN
|||||||||| .|. . .    ...  .||. |.||.||. |...||.. |||.|   . || .  .  ||  |
VhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 61-348 6.3e-50 165.0 In-house 21-314 (318) alignment 
Range on Protein: 61-348
Range on HMM: 21-314/318.0
NMTREFRNNK--EYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVML
....|. . .  | ..  . |...    ||||  |   |. || |..   ... ||| |...       ..|..|.|. .|| ||| ||.  .. |||||
llseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

CQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKtVELwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN---KSSSKPIVV
 |  |. ..|..||. .   ..||. .|.. |. ||| .   .  ..|.....  . .|  | | .| |.  | ..| .... . | .   ||. .||||
tqeeergkakvhryWPskgsrsygklvvelkee.vel.sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRNANYESLLKKYADVTRKVTAAIMEEE
||||||||| .|. .      |.... ||. .. |.||. |   || . ||...   ..|  .  .      .  | ...  ..  ..  . |. |
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpesgttemdae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 61-307 1.4e-35 117.5 In-house 25-270 (287) alignment 
Range on Protein: 61-307
Range on HMM: 25-270/287.0
NMTREFRNNKEYKPnvttsisekmMDKNRYRHIFCGDDNRVVL-KERDPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQY
 .|  |.. .|             . |||| ...  ||.||.| .| .   ||| | ..    |  .||..||||  |. ||| .|. ..  ..... . 
sstatfkaaeelaa..........vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtre

IEEDQEKCQRYFSDTsEK--EYGDYRVKVVEKTVELWNpVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV-----LNKSS--SKP
.|| . || .|. .  |.    | | | ......   .   |  ... . .    ..|  . ...| |.|..     .|..   |     |....    |
veearlkcykywPer.evPmrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGP

IVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLV
.|||...|.||. ... ..    .  .   ||.  .. |||  | . ||. .|. .|.
lvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrlly
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-307 4.1e-30 99.5 In-house 16-286 (301) alignment 
Range on Protein: 61-307
Range on HMM: 16-286/301.0
NMTREFRNNKEYKPN-VTTSISEKMMDKNRYRHIFCGDDNRVVLKERDP----SNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVM
..  .... ||....  | ..||.    ||...|   ||||..||.       ...|| ||..  . .  .|| .|||.|.|..|||.... ||   |||
kfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVE-------------LWNPVK----VTGIQVQKKNcpTKHMVYHYFYYDWHDQVAPLDPAPMIKM
...  |. ..||..|.........  . ..|  .                . .  .       ..|....  . . |  .   || ..    .|. ... 
vtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqv

YKAVLN---KSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLV
   |.    | .  |.|||||..|.|. ... . ..    . .  ||.... |..|  . |||.   ||. . 
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiy
subfamily_egg_pd Subfamily egg 61-335 2.4e-28 93.7 In-house 15-293 (307) alignment 
Range on Protein: 61-335
Range on HMM: 15-293/307.0
NMTREF--RNNKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVML
.. | .   ..   . ..||..|.  ..| | ... | |  || |. |    ..|.|||  .   |   .|| .| |.|||  ||| ||. |... ||||
elerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml

CQYIEEdqEKCQRYFSDTSE--KE--YGDYRVKVVEKTVELWNPVKVTGIQVQKKNCPTKHmVYHyFYYDWHDQVAPLDPAPMIKmykavLNKSSSKPIV
    |   |.|. |.  . .       | .|.. ..   .     .|| ...   .   .. . | . .|..       |  ...     . .  |||.|
tsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerf.leh.wqgdvnnssdvysplrvlr.....klrnlskpvv

VHCSAGVGRTSTFVGIYLSQI-MIRENSSV-DMVEILKRLRTMRLGAVQSQLQYVYLVVLMIeLFIDDKII---KRNANYESLLKKYAD
|..  || ...|.| | .. . ..|       . .  . ||  |  .|.| |.|...  |.. .|. | |    . . .||  |.....
vqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl.fffrdvigsakeldvdyerwleerse
subfamily_eak_pd Subfamily eak 61-229 9.4e-15 48.8 In-house 30-196 (332) alignment 
Range on Protein: 61-229
Range on HMM: 30-196/332.0
NMTREFRNNKEYKPNVTTSISEKmMDKNrYRHIFCGDDNRVVLKERD-PSNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQY
|.  .. .... .    |.  |. ...|   .|   | . | |       . || || . ... | ..| |  . .. .  || ||. .|   ||.| . 
nivadlddyqrllsisetarlea.vnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlled

IEEDQEKCQRYFSDTS--EKEYGDYRVKVVEKtVElWNPVKVTGIQVQKKNcpTKHMVYHYFYYDWHDQVAPL
.|.. || ..|| | .  | ..| . |.  |  |.  | ...  ....| |    | |.|| .. | .   | 
velkleksdkyfpdktreelkfGildverkef.vk.rniletrllelskGn..ethrvlhykvfGwtettlpk
0046845 (Phosphotyrosine protein) phosphatases II 62-314 6.3e-72 237.7 In-house 2-274 (284) alignment 
Range on Protein: 62-314
Range on HMM: 2-274/284.0
MTREFRNNKEYKP----NVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPS---NDYIHASWMVMP------DGFQFISTQGPIKNTIADFWHMVYTEK
. .||.    ...    ...... .. ..||||..|.. |..||.||  |..   .|||.||.. ..         .|| |||| .||..|||.||. ..
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CHVIVMLCQYIEEDQEKCQRYFSDTS-EKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKN-CPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--
..|||||.. .| ..||| .|.....  ..|||..|......|   . ..|. ....... .   ..|.|. | .| |. .| .|.........| .   
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

--SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENS---SVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
  ....||||||||||||| ||. ..|   ......    ||. |..||||..| |.||.  ||...  ...|..
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 62-315 8.2e-49 161.0 In-house 21-276 (280) alignment 
Range on Protein: 62-315
Range on HMM: 21-276/280.0
MTREFRNNKEYkpNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPsnDYIHASWMVMPD-G----FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLC
  . .| ...   .....   . ..||||| |   |. || ||| .   ||| |... |   .     ..|.||||...| .|||.||. .|...|||| 
feqlyrkkpgl..aisaarkpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

QYIEEDQEKCQRYFSDTSE-KEYGDYRVKVVEKtvELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--SSSKPIVVH
. .|. . || .|. .|..  |||...||. ..  .  . . .  . ...|.   .... .  | .| |.  | |.| .... . | ..  ....|.|||
tlverGrvkChqyWPetedeleygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
||||.|||  .. . ..  .| .. .| ...|....|  |   ||.. || ..   ..... 
CsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPRG_pd Subfamily PTPRG 62-314 2.1e-46 153.3 In-house 21-287 (563) alignment 
Range on Protein: 62-314
Range on HMM: 21-287/563.0
MTREFR--NNKEYKPNVTTSIS--EKMMDKNRYRHIFCGDDNRVVLKER---DPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIV
...||   ...  . ..... |  ..   ||||  |   |  || |..    . . ||| |...     . .|| ||||.|.|. |||.|.. .. ..||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVELWNPVKVTGIQV----QKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMY--KAVLNKSSS
|. .  |. ..||..|.     ..||  .|. .|. |     |.   |.     .||.| |...|..| | .| |. .|  ..| ...   ..  ||.  
mitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaea

KPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
 ||||||||||||| |.. .      |.....|.. ..||..|..|   ||.. ||..|   ..|. 
GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_PTPN1_pd Subfamily PTPN1 62-321 4.2e-43 142.1 In-house 11-281 (290) alignment 
Range on Protein: 62-321
Range on HMM: 11-281/290.0
MTREFRNNKEyKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDpsNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIE
. .. |.. . . .....  ..  ..|||| .   |  |..|.. |  |||| || . ...   ..| ||||. ||.. ||.||. .|.. .||| . .|
iyldirkeas.dfptreaklpenrnlnryrdvspydhsriklerad..ndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

EDQEKCQRYFSDTS---EKEYGDYRVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS----SSKPIVVH
..| ||..|.       | .. | ..||   . |  .  .|  ........   . ..|. |  | |   |  || ..|.   | .         | |.|
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavih

CSAGVGRTSTFVGI--YLSQIMIREN-SSVDMVEILKRLRTMRLGAVQS--QLQYVYLVVLMIELFI-DDKIIK
||||.||. ||. .   | .|  ... ||||. . |  || .||| .|   ||.. || .|    .| .|  ..
csaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 62-310 6.1e-40 131.8 In-house 20-272 (515) alignment 
Range on Protein: 62-310
Range on HMM: 20-272/515.0
MTREFRN--NKEYKPNvTTSISEKMMDKNRYRHIFCGDDNRVVL--KERDPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLC
.. ||..    .  |. | .  |    ||||. |.  | .|| |   . .| .||. || .   |    .|..||| | .. |||..|. |.   |.|. 
fseefhdlpgpniypq.tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

QYIEEDQEKCQRYFSD--TSEKEYGDYRVKVVEKTVElWNPVKvTGIQVQKKNCptKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS--SSKPIVV
.  |.|. || .|. |  .   ..| ..|..|       . .|   ..| | .    . |  . . .| |. .| .   ..|. |.|  .    . |...
klkegdkikcgkyWPdkpgdsvkfGsikvelvsleac.tggik.rkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythplii

HCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
|||||||||  .. |      ...  .||. .... .|  |   || | || ..   .
hcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
DSPc_SM00195 63-314 1.4e-73 242.9 In-house 6-262 (263) alignment 
Range on Protein: 63-314
Range on HMM: 6-262/263.0
TREFRNNKEYKpNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMVMP-DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYI
 .. ..... | ..|... .| ..||||..|.. |..|| ||...  ...|||.|... ..    ..| |||| ..|..|||.||. ||...||||..  
fekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EEDQEKCQRYFSDT--SEKEYGDYRVKVVEKTVELwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSS--SKPIVVHCS
|...|||.||. ..  .....|...||.||.. .  . .... ....|... ... |..| | .| |. .| .. .......|| ...|  |.|||||||
engkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

AGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
|||||| ||| | .    ..|.. ||. ||.|.||. | |.||.. || ...  ..|..
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 63-314 1.4e-73 242.9 In-house 6-262 (263) alignment 
Range on Protein: 63-314
Range on HMM: 6-262/263.0
TREFRNNKEYKpNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMVMP-DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYI
 .. ..... | ..|... .| ..||||..|.. |..|| ||...  ...|||.|... ..    ..| |||| ..|..|||.||. ||...||||..  
fekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EEDQEKCQRYFSDT--SEKEYGDYRVKVVEKTVELwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSS--SKPIVVHCS
|...|||.||. ..  .....|...||.||.. .  . .... ....|... ... |..| | .| |. .| .. .......|| ...|  |.|||||||
engkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

AGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
|||||| ||| | .    ..|.. ||. ||.|.||. | |.||.. || ...  ..|..
aGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 63-314 2.9e-51 169.2 In-house 28-285 (293) alignment 
Range on Protein: 63-314
Range on HMM: 28-285/293.0
TREFRNNKEYKPNVTTSISE--KMMDKNRYRHIFCGDDNRVVL--KERDPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQ
. |. . |. . . .....|  .  .||||. |   | .|| |   . ....||| |...       .||.||||. .|. |||.||. .|...|||| |
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltq

YIEEDQEKCQRYFSDT-SEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKKNcpTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS----SSKPIVV
 .|. ..||..|. .. ..  ||| .|..|....   .   .  ....|..  ... | .| .  | |   | ........ ..| ..     |..||||
lvekgkvkCeeYWPadeepvlyGdikvtlvaeeel..edwvirelkiekek..eerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
||||||||| ||. .      |.|.  ||.. |. .||. |   ||.. ||...   ...|.
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 63-318 1.8e-46 153.6 In-house 29-289 (297) alignment 
Range on Protein: 63-318
Range on HMM: 29-289/297.0
TREFRNNKEYKPNVTTSISEK-MMDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMPDGfQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYI
. ||.   | .   .|   .|  ..|.||. |   | .|| |.    ||. ||. ||..      ..|.|| | |.|.|||| ||. |.  .|||| .  
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddn

EEDQeKCQRYFSDTSEKEYGDyrVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPL-DPAPMIKMY----KAVLNKSSSKPIVVHC
|.|. ||.||.||.. ...||  | || ..|.  .      ..|.| .  ....|  | . .| |.. .  | |...  .    . . .. .. |..|||
erdk.kcaryWsdkgvttfGd..vsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc

SAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI-DDK
.||||||. .. |      .... .||. ...|.||  |   || . || .. |...| .. .| 
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 64-309 2.3e-49 163.0 In-house 19-273 (281) alignment 
Range on Protein: 64-309
Range on HMM: 19-273/281.0
REFRNNKE--YKPNVTTSISEKMMDKNRYRHIFCGDDNRVVL--KERDPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQY
.|... ..   .   | | ... . ||||. |.  |  ||..  .|.. ..||| |...  . .  ..| ||||. .....||.||. .| ..|||. . 
eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtre

IEEDQEKCQRYFSDTS-EKEYGDYRVKVVEKTVELWNpVKvTGIQVQKKNCPTKHmVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK---SSSKPIVVHC
||... || ||. | . | .|||..|| .... .    ..   .........|.. | .  |  | |. .| ... ...  |.||.    ..  |.|.||
ieagklkChrYWPddnselkygdvtvkstaeeekaty.ie.rkfkleresgetre.veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC

SAGVGRTSTFVGIY-LSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYL--VVL
||||||| |....  | . . .|....|. .... ||  |   ||. .|| ..  .||
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 64-312 1.9e-33 110.6 In-house 10-257 (267) alignment 
Range on Protein: 64-312
Range on HMM: 10-257/267.0
REFRNNKEYKPN---VTTSISEKMMDKNRYRHIFCGDDNRVVLkeRDPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYI
.|| . |.  ..   ...||.||  ..||. .    ||.||.|  |.  ..|| ||..     . .|| ||.|.||||.||. ..  .|. |||.| .  
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvil..rtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf

EEDQEkcQRYFSD-TSEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKKNCpTKHMVYHYFYYDWHDQVaplDPAPMIKMYKAVLNK----SSSKPIVVHC
...    . .       |.| |  |.   .  |  |  ..  .... ||  . | |  |.|  |  ..   .  | .|   ..| |      ..|.||.|
tdnir..lfwPPkmgqakkyqdltvehslekee..ndyqiitlelkfkne.sahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvvac

SAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
|.||||. ||. |.     ..... .|. . |...|  | | |... .|.|.  |. |
sdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0043336 (Phosphotyrosine protein) phosphatases II 65-313 5.1e-70 231.4 In-house 28-276 (278) alignment 
Range on Protein: 65-313
Range on HMM: 28-276/278.0
EFRNNKEykPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEE
|....|   .. ....... .|||||..|.. | .||.|.  .  ...|||.||.. ... . .|| |||| ..|..|||.||. .....||||..  | 
ellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvel

DQEKCQRYFSdTSEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--SSSKPIVVHCSAGVG
...||..|..  . ..|||..|.... ..   . ..|. . | .. .. ...|.|| |..| |. .| .........|||...  .|..|..||||||||
grvkcaqYwp.ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvg

RTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
|| ||...||   ... .  ||. |..|.||..| ||||.. ||..|  ...|.
RTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 68-160 6e-11 36.5 In-house 20-121 (347) alignment 
Range on Protein: 68-160
Range on HMM: 20-121/347.0
NNKEYKP-NVTTSISEKMMDKNRYRHIFCGDDNRVVLK-------ERDPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQY
|  .| | ..|..  || ..||| ..    |. ||||        . |... || || . . .   ..| || |. .|. |||.||.  |   .| . . 
nlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

IE
|.
ik
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 69-310 1.9e-51 169.7 In-house 31-279 (290) alignment 
Range on Protein: 69-310
Range on HMM: 31-279/290.0
NKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLK----ERDPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQ
. | . .||. ....   .||...|   ||||..|.    ..| .|.||.|...    .  |.| ||||..||..|||.... ||. .||||.. |||..
sgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegk

EKCQRYFSDTSEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKKNC-PTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN---KSSSKPIVVHCSAGVG
.||| |..|.. |.|| ...|... ..   |    . ..|..||   .|..| .|    |...    .|. .. ... . .   |.  ..||||||..||
vkCqqYWpdsdtkaygefsikllneetl..neyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvg

RTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
|...|. .. .    . .  .|....||..|. . | ||.. || ... ..
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_PTPN14_pd Subfamily PTPN14 69-312 4e-41 136.0 In-house 34-294 (300) alignment 
Range on Protein: 69-312
Range on HMM: 34-294/300.0
NKEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLK-ERDPSNDYIHASWM---VMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQE
.|. . ...|.  ..  .|||....   .|||| |.  .. |..|| || .   |     ..| .|||...|. |||.||. .. ..|||| . .|. .|
kkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KCQRYFSDT----SEKEYGDYRvkVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMY---KAVLNKSS--------SKP
|. .|| ..    .. |.| ..  |..| .|  . |  ||....      .  |.|  | || |.  | |. ....     ..| .|..        . |
ksfkyfPkleskkktvefgkfk..vttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

IVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
..||||||||||   .   |    .  | ..|. ..|.|||. |   ||.  || ..  ..|.
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 69-318 3.4e-39 129.3 In-house 43-293 (305) alignment 
Range on Protein: 69-318
Range on HMM: 43-293/305.0
NKEYKPNVTTSISekmMDKNRYRHIFCGDDNRVVLKERDPSnDYIHASWMVMP--DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKC
.. .. | .. |.   . ||||. . | | . | |..  || ||||| ..  |     .|| .|||. .|| .|| ||  .|   |||||. .|  . ||
qvafnanqsadia...itknryqdvpcqdqsavkldkpsps.dyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkc

QRYFSDTSEkEYGDYRVKVVEKTVELWNPVK-VTGIQVQKKNC----PTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVlnKSSSKPIVVHCSAGVGRT
 .|.  .   |  . .  .| . |   .|..  . ||.   |       |  | |  . .| |.  |      ...  |.  . |  |||||||||.|||
aqywpaaqg.eklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai..rgskvpivvhcsagigrt

STFVGIYLSQIMIRENS-SVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDK
 | | |      | ||     | |..| ||  |  ..|...||...  .|.. |..  
gtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 69-312 2.9e-32 106.7 In-house 29-277 (439) alignment 
Range on Protein: 69-312
Range on HMM: 29-277/439.0
NK----EYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKER--DPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEE
 .    .|. . .    |    ||||. .   |  ||.|.|    |   || | ..    |   .|.|||| |.|  ||| .|. .|.  ||||.. .| 
instspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves

DQekcqrYFSDTSEKEYGDYRVKVvEKTVELWNPVkVTGIQVQKKNCPTK--HMVYHYFYYDWHDQVAPLDPAPMIKMYKAVL---NKSSSKPIVVHCSA
 .     |.   .|  |||  |.| .. .|| | | . |..| ..   |.  . | .. |  | |.  | . . .... .|.    .|    |.||||||
yk.....ywpsdaevcygdiavrv.drnielpnyv.irgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsa

GVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
||||| | . . ..   .. .  ||.  |.| ||  |   ||.  |||..   ..|
gvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 70-326 3.4e-62 205.0 In-house 20-282 (285) alignment 
Range on Protein: 70-326
Range on HMM: 20-282/285.0
KEY-KPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKERDpsNDYIHASWMVMP--DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKC
| |  ||.| .  |   | |||  . | .. |||||..|   |||||||| ||  |   .|.||||. .|..|||||.| ||   ..|||  .|   |||
kgymppnctytayeanpdlnryadvrcieetrvvlknhd..rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

QRYFSDTSE--KEYGDYRVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVY--HYFYYDWHDQVAPLDPAPMIKMYKAVLNK-SSSKPIVVHCSAGVGRT
  |. .      ..| | . . |   |      .  . | . .  .   .|  |     | ||.|| |  |||..|| | .     |||.||||||||||
alyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrt

STFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRNANY
.|||||  . | | ||  ..|..|.. .|.||. ||||..|...| |...| || . ...| .. 
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvvertgqi
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 70-319 1.9e-51 169.4 In-house 38-288 (290) alignment 
Range on Protein: 70-319
Range on HMM: 38-288/290.0
KEYKP--NVTTSISEKMM--DKNRYRHIFCGDDNRVVLKERDPsNDYIHASWmVMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEK
| | |   .  .| .|     ||||. . | |  ||.||.  .  ||.|| . |      || |||..|.|. |.| ||  ||  .|||||. ||. . |
kpylpvqylerkifdkntefkknrykdvvcndktrvilkdGyd.Gdyvhany.vkGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkak

CQRYFSDTSEK--EYGDYRVKVVEKTVELwNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVlnKSSSKPIVVHCSAGVGRTST
|..|. ... .   .|.. |   |.. .  . ..   . |..|.   .|...|.    | |.  .|    .... ...  .  | |.|||||||.||| |
ceqyypekeGevltfGeitvlcseeddkd.aniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril..rkasGpvvvhcsaGiGrtGt

FVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKI
|| |  .  .. .  ..|.... . ||  ||..|| ..||. || ....|  | | 
fvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfky
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 70-309 9.6e-49 160.9 In-house 33-273 (287) alignment 
Range on Protein: 70-309
Range on HMM: 33-273/287.0
KEYKPNVTTSISEKMMDKNRYRHIFCGDDNRVVLKerDPSNDYIHASWMV-MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQR
.. . .|| .|...  ||||...|   |..||.||  .  .||| |...    .  .|| ...|. ||. .||...  .. ..||||||  |.|.|.| .
tqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyq

YFSDTSEKEYGDYRVKVVEKTveLWNPVKVTGIQVQKKN-CPTKHMVYHYFYYDWHDQVAPLDPAPMI----KMYKAVlNKSSSKPIVVHCSAGVGRTST
|.....   .|.|........    . . .  ..|..||   .|..|  | . .|...    .|. ..    .|||.   |..  .||||||..|||...
yWpeeksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq.rkrgntsivvhCsdtvGrsam

FVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVL
|. .  .    ...  .|....||. |  . |.||   || ... .
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindi
0045098 (Phosphotyrosine protein) phosphatases II 72-314 3.6e-65 215.4 In-house 21-272 (278) alignment 
Range on Protein: 72-314
Range on HMM: 21-272/278.0
YKPNVTTSISEKMMDKNRYRHIFCGDDNRVVlkerdpsnDYIHASWMVMPdGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFS
.   .|... .. .|||||..|.. | .||.        |||.||.. .. ...|| |||| ..|.||||.|.. ....|||||.. .| ..||| .|. 
ipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

DTSEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKK----NCPTKHMVYHYFYYDWHDQVAPLDP--APMIKMYKAVLNKS---------------SSKPI
. . ..|||..|.... .|   . . .. . |.      .  ... |.|. |. | |  .| .|  ........ ...                 |..|.
eggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSAGVGRTSTFVGIYLSQIMIreNSSVDMVEILKRLRTMRLG-AVQSQLQYVYLVVLMIELF
.|||||||||| |.|..||   ..  .. ||. |..| ||..| | |||.. ||..|  ...||.
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 74-319 5.8e-43 142.4 In-house 12-262 (284) alignment 
Range on Protein: 74-319
Range on HMM: 12-262/284.0
PNVTT---SISEKMMDKNRYRHIFCGDDNRVVLKERDP--SNDYIHASWMVM-PDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCqyieedQEKCQ
.| |.   .  ..  ||||. ||.  | |.| |.  .     ||| ||..       ..|.|||| .||.|||| |..  .|  ||.|       ..|| 
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

RYFSDTSEKEYGDYRVKV--VEKTVElwnpVKVTGIQVQKK-NCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV---L-NKSSSKPIVVHCSAGVGR
.|.    ..... ..|||  ||.. |      |  |.. .. .   .  .  . .  | |.  |  |...... | |      .   ..|||||||||||
qywplkivikeerfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

TSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE--LFIDDKI
| ... .     ...|.. ||. .... ||  |   ||.  || .. . ..|  ||    .
tgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
0040439 (Phosphotyrosine protein) phosphatases II 75-314 5.7e-65 214.7 In-house 2-246 (249) alignment 
Range on Protein: 75-314
Range on HMM: 2-246/249.0
NVTTSISEKMMDKNRYRHIFCGDDNRVVLKERD--PSNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFS
...... .. .|||||..|.. | .||.|.  .  . .|||.||.. ... . .|| |||| ..|..|||.|.. ....|||||..  | ..|||..|..
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DTSEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS----SSKPIVVHCSAGVGRTSTFVGI
. ...||||..|.... .|   . ..|. ...... ......|.|. |.||.|. .| ..........||..      ...|..|||||||||| ||...
lggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

YLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELF
||   .....  ||. |..| ||..| ||||.. ||..|  ...||.
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 75-347 3.8e-50 165.6 In-house 43-328 (330) alignment 
Range on Protein: 75-347
Range on HMM: 43-328/330.0
N------VTTSISEKMMDKNRYRHIFCGDDNRVVLKER--DPSNDYIHASWMvmpDG----FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEED
       . ..  |. ..|||. .|.  | .||.| ..   .. ||| ||..   ||     .||..||| ..|. ||| |..  | . |||| .  | .
agpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfi...dGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerk

QEKCQRYFSDTSEKEYGDYRVKVVEKTVELWNPVKVTGIQVQKKNC--PTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAV--LNKSSSKPIVVHCSAGV
.|||..|. |     ||. ||.| ..||     |.   .| . ...   .. .|  . .  | |   | .|  |.|. |.|  ||. |. ||||||||||
eekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGv

GRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI-DDKIIKRNAnYESLLKKYADVTRKVTAAIMEE
||| ||. .     ... .  ||. |..||||. |   ||.. ||...   . | ..  |  ..  .  |. |.|  . . ...   .||
GrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvss.lekhlqklynkitgtdkiglee
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 76-312 1.2e-41 137.4 In-house 25-264 (283) alignment 
Range on Protein: 76-312
Range on HMM: 25-264/283.0
VTTSISEKMMDKNRYRHIFCGDDNRVVLKERDPsnDYIHASWMV----MPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFS
.. . ...   |||...|   | .|| ||   .  ||| |....      .. ..| .|.|...|. |||.||. ||   |||| .  |. ..|| .|. 
adiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

DTSEKEYGDYRVKVVEKTVELWNPVKVTGIQVQKkNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYK--AVLNKSSSKPIVVHCSAGVGRTSTFVGIYL
    ..||.. | . . | .    .|   ..|.   . .. .. || . || .         ..|. |  .  ..|   |||||||.|.|||..|...  
krGsedyGeftvtlrkettsnsfiikelllrvns.sakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasa

SQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
|   .. .| ||. ...| .|  | .|||.. ||  .  |..|
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG7180_pd Subfamily CG7180 76-315 6.1e-32 105.4 In-house 34-291 (296) alignment 
Range on Protein: 76-315
Range on HMM: 34-291/296.0
VTTSISEKMMDKNRYRHIFCGDDNRVVLKER--DPSNDYIHASWMvmpDG----FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQeKCQRY
  . . .....|||. ..   | |||||..   . ..||| |...   |.     ..| |..| |.|. .|| .|| |... .|.|..  .  . ... |
CagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyv...dsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsy

FSDTSEKEYGDYRVKVVEKtvELWNPVKVTGI-----------QVQKKNCPTkHMVYHYFYYDWHD-QVAPLDPAP---MIKMYKAVLNKS----SSKPI
.  .|...||.  |..||.  . .  .|   .           | .. . .|  .| .. .  |.  .  ||  .    .... . . .|       .|.
wpnkskeqygeifveivee..kqyanlkirtfkltkkivalteqekqvkaet.RivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPv

VVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
||..| |..|.  ...|  .  .....  ||. | .|.||  | . |..  .| |.  .. | ..
vvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 77-312 3e-29 96.6 In-house 38-234 (392) alignment 
Range on Protein: 77-312
Range on HMM: 38-234/392.0
TTSISEKMMDKNRYRHIFCGDDNRVVL--KERDPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDqekcqryfsdt
|..  |  . ||||. |.  | .||.|   .  | .||. ||..   |    .|..|||   .. |||.||. |.   |.|. .  | |           
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

sekeygdyrvkvvektvelwnpvkvtgiqvqkkNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--SSSKPIVVHCSAGVGRTSTFVGIYLSQ
                                 .   .. |  ... .| |.  |   . ..|. | |  .  . ..|...|||||||||   . |    
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvv

IMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIE
   ..   ||.....  .|  |   ||.. || ..   ..|
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 77-231 2.3e-28 93.9 In-house 26-183 (297) alignment 
Range on Protein: 77-231
Range on HMM: 26-183/297.0
TTSISEKMMDKNRYRHIFCGDDNRVVLKERDPSNDYIHASWMVMPD---GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSD-
...  .  . |||||.|.  ||.|| |.   . .||| | ..|.||    ...| .|||...|. |||..|. .   ||||...  |. ..||  |. . 
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

-TSEKEYGDYRVKVVEKTVELWNPVKVTGIQVQKKncPTKHMVYHYFYYDWHDQVAPLDP
    .. ||. |. . .| . .. |..| .|.  .    . .| |  .  | |   | | 
vqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 77-189 8.7e-20 65.7 In-house 40-166 (350) alignment 
Range on Protein: 77-189
Range on HMM: 40-166/350.0
TTSISEKMMDKNRYRHIFCGDDNRVVLK----------ERDPSNDYIHASWMVMP-------DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYI
  |   ... ||||. |.  . .|| ||              .|||| |... ..        .|..|.||.|...|. ||.....  | .||..| . .
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EEDQEKCQRYFSDTSekeYGDYRVKVVEKT
| . |||.||. . |   | |. ||. .| 
elnlekcyrYWqegs...ydditvklaskw
0037934 (Phosphotyrosine protein) phosphatases II 78-313 1.8e-61 203.1 In-house 4-241 (243) alignment 
Range on Protein: 78-313
Range on HMM: 4-241/243.0
TSISEKMMDKNRYRHIFCGDDNRVVLkerdPSNDYIHASWMVMPDgfQFISTQGPIKNTIAD----FWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSdt
.....  ..||||..|.. |..||.|    ...|||.|... ...  ..| |||| ..|..|    ||.|.. ....|||||.. .| ..||| .|..  
iallpenlsknrysdilpydhsrvkl....egsdyinanliyvtp..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

SEKEYGDYRVKVVEKTVelWNPVKVTGIQVQKKN-CPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVL----------NKSSSKPIVVHCSAGVGRTS
.|..|||..|.... ..   . ..|. .... ..  . ...|.|| |. | |. .| .|...... ..|           . .|..|..|||||||||| 
gevtygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

TFVGIYLSQIMIrensSVDMVEILKRLRTMRLG-AVQSQLQYVYLVVLMIEL
|.. .||   ..    .||. |..|.||..| | |||.. ||..|  ...||
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 79-307 1.7e-37 125.2 In-house 41-273 (314) alignment 
Range on Protein: 79-307
Range on HMM: 41-273/314.0
SISEKMMDKNRYRHIFCGDdNRVVLK-ERDPSNDYIHASWMVMPdgFQFISTQGPIKNTIADF----------WHMV--YTEKCHVIVM-----------
.  .. .||||| .|.. | |||.|. .   . |||.||..  .   .|| |||| ..|. ||          |.||  .  ....|||           
adlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCQYIEEDqekcqryfSDTSEK-----EygdyrvkvvektvelwnpvkvtgiQVQ--KKNCptKHMVYHYFYYDWHDQVAPlDPAPMIKM
          |..  .          .  ...     .                        ...  .. .  ......|..... |  || ... . ..
rLdaAlgKtpllildgng........neptaadlellk........................eelydpelf..erlgikylripvpDgsap.lledfdef

YKAVLNKSSSKPIVVHCSAGVGRTSTFVGIYLsqIMIREnsSVDMVEILKRLRTMRL-----GAVQSQLQYVYLV
...... .  .|..|||.||.||| ||| ...  .|..    |.. |.|...| .|      |......||..  
lefieeadkggpvlvHCkaGkgRtgtfvvaay..lmkll..gvsleealedvrlkRpinpnpgfieqleqyefil
0042113 (Phosphotyrosine protein) phosphatases II 80-313 6.8e-65 214.2 In-house 5-242 (245) alignment 
Range on Protein: 80-313
Range on HMM: 5-242/245.0
ISEKMMDKNRYRHIFCGDDNRVVLKERDPS--NDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEK
. .. .|||||..|.. |..||.|.. ...  .|||.||.. ...   .|| |||| ..|..|||.|.. .....||||..  | ...||..|... ...
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

EYGDYRVKVVEKTVelWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLN---KSSSKPIVVHCSAGVGRTSTFVGIYLSQIM
.|||..|.... ..   . ..|. ..|... .. ...|.||.|..| |. .| ... .......|..   ..|..|..|||||||||| ||...||   .
tygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

IRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL
....  |.. |..|.|| .| ||||.. ||..|  ...||
lekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 80-328 1.4e-39 131.1 In-house 44-302 (325) alignment 
Range on Protein: 80-328
Range on HMM: 44-302/325.0
ISEKMMDKNRYRHIFCGDDNRVVLK--ERDPSNDYIHASWMVMPDGF-QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCqYIEEDQEKCQRYFSDT--S
   . ..|||.. .   | .||||.  . ||| ||| ||..    .   |...| |  .|| |.| .|.  .| |.|.|   .......|  |. .    
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvln.eldlgkdrcavywpkemgk

EKEYGDYRVKVveKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMY---KAVL-----NKSSSKPIVVHCSAGVGRTSTFVG
 |..|  .||.  .|.|         ..|.. .      |  . .  | |   .  || .| .    |||      |  .| ||.|||||||||| .|. 
sktfGglevkl..rtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKIIKRNANYES
.|     . |.|.||. . .|.||  |   |..  ||. .   ..| ..  .     ...|.
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfea
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 81-334 1.2e-32 108.2 In-house 17-257 (290) alignment 
Range on Protein: 81-334
Range on HMM: 17-257/290.0
SEKMMDKnRYRHIFCgDDNRVVLKERD--PSNDYIHASWMVMPDGFQFISTQGPIKN-------TIADFWHMVYTEKCHVIVMLCQYIEEDQE----KCQ
 .. ||. |..  .   ..|||||.     ..|||||. . .|.| ..| || | ..       || .|| |.  || . .||||.  |....     |.
kkhemdq.RlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

RYFSDTSEKEYGDYRVKVVEKTVELWNPVKVTGIQVQKKNcPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLnkSSSKPIVVHCSAGVGRTSTFVGI
.|. .. ..|     ..|  |  |  . |..  . |.  .   .. | |. . .|..  .. |.  .... . |    |  |..|||  |. |  ..  |
kYvpesvgeelkfkgltvkCkskekeddvetRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaai

YLSQIMIR-ENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIelfiddkiikrnanyesllkkyA
 |.  .|   ..|| ....|| || .|  |..|.|.. . .  ..                       
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv......................l
subfamily_CG42327_pd Subfamily CG42327 82-243 3e-17 57.3 In-house 26-192 (319) alignment 
Range on Protein: 82-243
Range on HMM: 26-192/319.0
EKMMDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMPDG--FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDT----
    ||.|. ..    . ||||..   |... |..||..  .|    ..|..| . ... .||| .|.  .  ||| |..  |   ..| .|.       
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

SEKEYGDYRVKVVEKTVElwNPVKVTGIQVQKKNCPTKHMVYHYFYyDWHDQVAPLDPAPMIKMYKAVLN
... |||..| . .. |.  .   .. . ... .      . ||.| .| .   | ..|..| |   | .
ntslyGdilvtlkgrevk..dryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 83-309 4.4e-51 168.6 In-house 27-263 (274) alignment 
Range on Protein: 83-309
Range on HMM: 27-263/274.0
KMMDKNRYRHIFCGDDNRVVLKERDPSN---DYIHASWMVMPDGFQ--FISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEK-
.   ||||. |.  .  ||.|.......   .|| | ..  .|. .  ...||||. ||.||||.|.|.|...||||| .  |....||..|| |. .  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

---EYGDYRVKVVEKtvELWNPVKVTGIQVQKKNCptKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSS---S--KPIVVHCSAGVGRTSTFVGIY
   .|||  .||...     |  .|. . ... .   .. |.||.| || |. .| |. ..... . | .. .       |.|||||||.|||  |..| 
iserygdveikveki..verndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

LSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVL
..   .||.. ||...|   ||  | | ||.. || ..   
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihra
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 83-172 1.4e-09 31.9 In-house 33-124 (332) alignment 
Range on Protein: 83-172
Range on HMM: 33-124/332.0
KMMDKNRYRHIFCGDDNRVVLKERDPSNDYIHASWMV-MPDGFQFISTQGPIKN-TIADFWHMVYTEKCHVIVMLCQyIEEDQEKCQRY-FSD
. || ||  |..| | .|| |  .|  .|.  |||.        .| .| |... |   ||.||   |  .|... . |.| |..   |  ||
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd.idekqkrkapydisd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 84-310 1.6e-47 156.8 In-house 9-238 (250) alignment 
Range on Protein: 84-310
Range on HMM: 9-238/250.0
MMDKNRYRHIFCGDDNRVVLKER--DPSNDYIHASWMVMPDG-FQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEkCQRYFSDTSEKEYGD
  .|||| .|   |  ||||..   |   ||| ||..   |.   || ||||...|| ||| ||. ||  .|||| .  |.... ...|.     ..|||
nkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGd

YRVKVVEKtvELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK---SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIREN
 .|.. .|  | .  .... ... |..   . .| .. .  | |.  |     .... | |  .   . ..|..|.|||||||. .|. |.     ....
vtvsllsk..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkke

SSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
  ||. ...|.||. | .||.|. |||..  ..
kvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 84-333 2e-41 136.9 In-house 49-302 (315) alignment 
Range on Protein: 84-333
Range on HMM: 49-302/315.0
MMDKNRYRHIFCGDDNRVVL--KERDPSNDYIHASWMVM-PDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTsEKEYGD
  .|||| .|   |  || |   | ||  ||. |...       ..|..|||  ... ||| .|. |..  |||| . .|....|...|. |  .  || 
nkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGk

YRVKVveKTVELWNPVKVTGIQVQKKNcpTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVL--NKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENS
. |    |  |  . . |  . |  ..    . |. . |  | |   |    |...... |   ...|  .|||||||||||| ||. .      .  . 
itvtr..kseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaen

SVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI-DDKIIKRN---ANYESLLKKY
 .|. ......| .| ..||.  || ..   ..| |.  |  | ..    .|.|||   
aidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllaps
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 84-177 5.6e-09 30.0 In-house 96-185 (244) alignment 
Range on Protein: 84-177
Range on HMM: 96-185/244.0
MMDKNRYRHIFCGDDNRVVLKERDPSNDYIHASWM-VMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQekcqrYFSDTSEKE
   |||    .  | ||| | .   .| || ||..  .    ..| || |. .|  |||.|.   .  |.|.|    |||.     |. |.   |
nswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseple
Y_phosphatase Protein-tyrosine phosphatase 85-311 1.4e-68 226.2 Pfam-A 2-234 (235) alignment 
Range on Protein: 85-311
Range on HMM: 2-234/235.0
MDKNRYRHIFCGDDNRVVLKERDPSNDYIHASWM-VMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFS--DTSEKEYGDY
..||||..| . |..|| ||... ..|||.|...   .. ..|| ||||.|.||.|||.||. ||..|||||..  |...|||..|..  .  ...|||.
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

RVKVVEKTVELWNPVKVTGIQVQKKNCPT-KHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS--SSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENS
.|...||. |  . . .. ....||. .. |..|... | .| |. .| .| ..... ..| ...  .|.|.||||||||||| ||| . .   ......
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

SVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMI
.||...|.|.||. | |.|||  ||..|. ...
evdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 85-311 1.4e-68 226.2 In-house 2-234 (235) alignment 
Range on Protein: 85-311
Range on HMM: 2-234/235.0
MDKNRYRHIFCGDDNRVVLKERDPSNDYIHASWM-VMPDGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFS--DTSEKEYGDY
..||||..| . |..|| ||... ..|||.|...   .. ..|| ||||.|.||.|||.||. ||..|||||..  |...|||..|..  .  ...|||.
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

RVKVVEKTVELWNPVKVTGIQVQKKNCPT-KHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS--SSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENS
.|...||. |  . . .. ....||. .. |..|... | .| |. .| .| ..... ..| ...  .|.|.||||||||||| ||| . .   ......
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

SVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMI
.||...|.|.||. | |.|||  ||..|. ...
evdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 85-310 1.6e-43 143.6 In-house 21-260 (270) alignment 
Range on Protein: 85-310
Range on HMM: 21-260/270.0
MDKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMP--DGFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEK--EY
   |||. |      ||.|.|   |.   || | ..     .  ..|...|| ..|. .|| |...|| . |||. .  |. ..||.||..  ...  ..
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

GDYRVKVVEKTVELWNPVKVTGIQVQkKNCPTKHMVyHYFYYDWHDQVAPLDPA------PMIKMYKAV--LNKSS--SKPIVVHCSAGVGRTSTFVGIY
 |  .||.  . |  .   .| .... ..  ....| |..|..| |. .| ..        ..|| .||   .|.   ..|..|||||||||| |.. . 
edgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

LSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
    .. |...||...|...||  |   ||   || .|   .
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykav
0041856 (Phosphotyrosine protein) phosphatases II 85-315 1.9e-42 140.3 In-house 2-172 (182) alignment 
Range on Protein: 85-315
Range on HMM: 2-172/182.0
MDKNRYRHIFCGDDNRvvlkerdpSNDYIHASWMVMPDGF-QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCqyieedqekCQRYFSDTSekeygdyrv
.|||||..|.. | .|         .|||.|......  . .|| |||| ..|.|||..|.. .....||.|.         . .|. .           
ldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell.........

kvvektvelwnpvkvtgiqvqkkncptKHMVYHYFYYDWHDQVAPLdPAPMIKMYKAVLNksSSKPIVVHCSAGVGRTSTFVGIYlsqI---MirensSV
                           ......|.|. | |  .|  .  .... ..||.  ...|..|||||||||| |.|..|   .   .     .|
...........................erlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaay...lmkkl.....gv

DMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
.. |..| .| .| |.|..  ||..|  .. ||. 
sleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 86-308 1.7e-39 130.5 In-house 5-233 (237) alignment 
Range on Protein: 86-308
Range on HMM: 5-233/237.0
DKNRYRHIFCGDDNRVVLKERDPSNDYIHASWMVMPDGF--QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSE-KEYGDYR
 ||||  | . | .|||||    . ||| |...   ||   ..|..|||....  ||| ||. ||| |||||   || ...|| .|. .| . . || . 
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VKVVEKtvELWNPVKVTGIQVQKK-NCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSS----SKPIVVHCSAGVGRTSTFVGIYLSQIMIREN
| .  |  | .    |  . ..|. .     ... | .  | |.  |   | .... | ..|.|     | | ..|||||||||  |. |       .|.
vslkkk..eefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakek

SSVDMVEILKRLRTMRLGAVQSQLQYVYLVV
  ||. . .. .   |   .|.. |||..  
kvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 86-311 5.2e-35 115.7 In-house 9-237 (239) alignment 
Range on Protein: 86-311
Range on HMM: 9-237/239.0
DKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMPDGF--QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKeYGDY
 ||||  |   | .||||..   || .||| ||..   ||    .|.||| .. .  |||.|.. |.  |||||   ||  ..||..|. |.. | | . 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnl

RVKVvEKTvELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS--SSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSS
|| .  || |..    .  . . .     .. ||.|..  | |.  |   . .. . . . . |   ..| |.||||||||| .|. |       ... .
rvtl.rkt.evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDMVEILKRLRTMRLGAVQSQLQYVYLVVLMI
||... .| .|  |   ||.  |||.. . ..
vdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 86-310 7.7e-35 115.2 In-house 10-237 (239) alignment 
Range on Protein: 86-310
Range on HMM: 10-237/239.0
DKNRYRHIFCGDDNRVVLKE--RDPSNDYIHASWMVMPDGF--QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKeYGDY
 ||||  |   | .||||..   || .||| ||..   ||    .|.||| .. .  |||.|.. |.  |||||   ||  ..||..|. |.. | | . 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnl

RVKVvEKTvELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKS--SSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSS
|| .  || |..    .  . . .     .. ||.|..  | |.  |   . .. . . . . |   ..| |.||||||||| .|. |       ... .
rvtl.rkt.evfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
||... .| .|  |   ||.  |||.. . .
vdifnyvkairedrphmvqtseqyvfihlav
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 86-187 3.5e-10 33.7 In-house 50-167 (349) alignment 
Range on Protein: 86-187
Range on HMM: 50-167/349.0
DKNRYRHIFCGDDNRVVLKERD----------------PSNDYIHASWMVMPD---GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKC
 ||||..|.  .  ||.||.                    .||| | .. ..     ...|.|| |.  |. ||....  .. .... | .  |.. |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

QRYFSDTSekeYGDYRVKVVE
..|. . |   | ...||. .
diywqels...ysnitvklqn
0046846 (Phosphotyrosine protein) phosphatases II 100-313 1.1e-37 124.8 In-house 2-172 (176) alignment 
Range on Protein: 100-313
Range on HMM: 2-172/176.0
RVVLKERDPSNDYIHASWMVMPdgfQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKEYgdyrvkvvektvelwnpvkvt
|..|   |.. |||.|......    .| ||||. .|.|||..|.. ......|.|.. .| .. || .|...  . ..                     
rlrllgldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

giqvqkkncptkhmvyHYFYYDWHDQVAPLDpAPMIKMYKAVLNKSSSK-PIVVHCSAGVGRTSTFVGIYlsqiMIRENSSVDMVEILKRLRTMRL-GAV
                .|....| |  .| . . ........ .  ... |..||||||.||| |.| .|    ... .  ... |.|...| .|  |||
................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QSQLQYVYLVVLMIEL
|.. || .|   . .|
qtpeQyrflyefelll
0044763 (Phosphotyrosine protein) phosphatases II 105-314 2.1e-29 97.8 In-house 13-171 (178) alignment 
Range on Protein: 105-314
Range on HMM: 13-171/178.0
ERDPSNDYIHASWMVmpdGFQFISTQGPikntiADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEkeygdyrvkvvektvelwnpvkvtgiqvq
|. .. |||.||...   .. ......|     ||.. ... .....||.|.. .|  ..|| .|. .  .                             
eglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

kkncptkhmvYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK--SSSKPIVVHCSAGVGRTSTFVGIYLSQIMirensSVDMVEILKRLRTMRLgAVQSQLQ
          ..|... ..|  .|  .. . ...... .   .. .|..|||||||||. |.| .||   .     .... |.....| .|  .|... |
..........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgq

YVYLVVLMIELF
. .|  .  .|.
lrqLyefelrll
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 106-205 7.4e-07 23.5 In-house 9-104 (130) alignment 
Range on Protein: 106-205
Range on HMM: 9-104/130.0
RDPSNDYIHASWMVMPD-GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQekcqrYFSDTSEKEYGDYRVKVVEKTVELWNPVKVTGIQVQ
| . |.||.||.. . .   ... || |. .|  |||.|.      |.|.|    |||.     |. |.   |. . .. |     .  . .| . ....
rlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdrdefknikasnleie

K
.
s
0043147 (Phosphotyrosine protein) phosphatases II 107-307 1.1e-36 121.5 In-house 2-154 (172) alignment 
Range on Protein: 107-307
Range on HMM: 2-154/172.0
DPSNDYIHASWMVMPDGF-QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYieedqekcqryfsdtsekeygdyrvkvvektvelwnpvkvtgiqvQK
|...|||.||.. ..    .|| ||||  ||.||||.|........||.|..                                              ..
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................ly

KNCPTKHMVYHYFYYDWHDQVAPlDPAPMIKMYKAVLN---KSSSKPIVVHCSAGVGRTSTFVGIYLSQimirenSSVDMVEILKRLRTMRLGAVQSQLQ
   . ......| |. | |. .| ... ...... . .   .|...|..|||||||||| |.| .|| .       .... |... .|..| ||||.. |
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YVYLV
| .| 
yrfly
0051429 (Phosphotyrosine protein) phosphatases II 109-315 6.7e-40 132.8 In-house 3-226 (272) alignment 
Range on Protein: 109-315
Range on HMM: 3-226/272.0
SNDYIHASWMVMPdgFQ------FISTQGPIKNTIADFWHMvYTEKCHVIVMLCQYIEEDQEKCQRYFS------------DTSEKEYGDYRVKVVEKTV
 ..||.|... ..  ..      .. ..|| ..|.||||.. .......||.|..  | ...|| ||              .. . .||..||.......
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

ELWNPVKVTGIQVQKKNCPTkHMVYHYFYYDWHDQVAPLDPapMIKMYKAVLNkssSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVD--------M
 |   . .  .  . ..  . ..|.|..|.|| |  .| ..  .... ...|.   ..|..||||||..|| |.| ..|.   . ..  ||        .
lldyilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

VEILKRLRTMRLGAVQSQLQYVYLVVLMIELFI
 |....|| .| ||||.. ||..|   ..||. 
eeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 109-307 6e-30 99.2 In-house 2-146 (151) alignment 
Range on Protein: 109-307
Range on HMM: 2-146/151.0
SNDYIHASWMVmPDgfqFISTQGPikntIADFWHMVYTEKCHVIVMLCQYIEEDqeKCQRYFSDTSekeygdyrvkvvektvelwnpvkvtgiqvqkknc
 .|||..|..  .    .. ..||     |||. ....... .||.|..  | .  .| .|. ...                                  
lsdyinfsyvt.gg...lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

ptkHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNkSSSKPIVVHCSAGVGRTSTFVGIYLSQIMirenssVDMVEILKRLRTMRLGAVQSQLQYVYLV
   . |.|. . ||.|.  || .. .... ...|.  ...|..||||||.||| |.|..||   .      |.. |.|. .| .| |.||.  |.... 
...ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql
0036282 (Phosphotyrosine protein) phosphatases II 110-307 2.8e-35 116.9 In-house 2-163 (174) alignment 
Range on Protein: 110-307
Range on HMM: 2-163/174.0
NDYIHASWMVMP---DgfQFISTQGPIKntiadFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDtsekeygdyrvkvvektvelwnpvkvtgiqvqkK
.|||.||.. .    .   .| .||| .     ||.|.. ......|||.. .| . .|| .|...                                 .
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................l

NCPTKHMVYHYFYYDWHDQVAPLDPApMIKMYKAVLNK---SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIReNSSVDMVEILKRLRTMRLGAVQSQLQY
    ......|.|. | |  .| ..  .....|.| .    ....|..|||||||||| |.|..||   ... .| || ......||..| |.||.. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

VYLV
 .| 
rfly
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 120-336 3.2e-30 100.0 In-house 39-241 (255) alignment 
Range on Protein: 120-336
Range on HMM: 39-241/255.0
MpdgfqfistqgpiknTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKE--YGDYRVKVVEKTVE-LWNPVKVTGIQVQKKncpTKHMVYH
.               |.. |....   | .|.|||| . ||..|||..||    ..   . |  | . . . . .   ...|    .||     | | |
l...............tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekk...kthtvkh

YFYYDWHDQVAPLDPAPMIKMYKAVLNkssSKPIVVHCSAGVGRTSTFVGI-YLSQIMIR-----ENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
|.|  | .. || ..  . ...|.| .   ||..|||||.|.||...|| . .. | |||     |   .| ...|. || .| .|..  ||  . ....
ysykGWieknaPelareilnilkvvrd...sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv

IELFIDDKiiKRNANYESLLKKYADV
..|.   .  . .|.|. . | |   
ldlvfpkg..eleakyqeirksylha
0049260 (Phosphotyrosine protein) phosphatases II 123-307 4.5e-35 115.9 In-house 8-143 (152) alignment 
Range on Protein: 123-307
Range on HMM: 8-143/152.0
GFQFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFsdtsekeygdyrvkvvektvelwnpvkvtgiqvqkkncptkhmvyHYFYYDW
.|.|| ||||  ||.||||.|... ....||||..  | . .|| .|.                                             .|... |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

HDQVAPLDPAPMIKMYKAVLN--KSSSKPIVVHCSAGVGRTSTFVGIYLSQimirenSSVDMVEILKRLRTMRLGAVQSQLQYVYLV
 |  .| ..  .. .....    .....|..|||||||||| |.| .||          |.. |.....|..| |||... |. .| 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 125-305 4.5e-19 63.4 In-house 5-194 (198) alignment 
Range on Protein: 125-305
Range on HMM: 5-194/198.0
QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYiEEDQEKCQRYFSDTSEKEYGDYR-VKVVEKTVELWNPVKVTGIQVQK--KNCPTKHMVYHYFYYD
..|.|| |...|.|||| ||.      |||. .  . ..|    ..  |.|   | |  . |. ||.       .| . . .     |.   . || .  
ryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WHDQVAPlDPAPMIKMY---KAVLNK---SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRE--NSSVDMVEILKRLRTMRLGAVQSQLQYVY
|... .| . | .. .    . | .|       |..|||| | | |  || . .      |   | ||. |. ||||  | | . |  .| .
wkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 125-305 4.8e-19 63.3 In-house 6-195 (199) alignment 
Range on Protein: 125-305
Range on HMM: 6-195/199.0
QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYiEEDQEKCQRYFSDTSEKEYGDYR-VKVVEKTVELWNPVKVTGIQVQK--KNCPTKHMVYHYFYYD
..|.|| |...|.|||| ||.      |||. .  . ..|    ..  |.|   | |  . |. ||.       .| . . .     |.   . || .  
ryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WHDQVAPlDPAPMIKMY---KAVLNK---SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRE--NSSVDMVEILKRLRTMRLGAVQSQLQYVY
|... .| . | .. .    . | .|       |..|||| | | |  || . .      |   | ||. |. ||||  | | . |  .| .
wkekttp.nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 125-206 7.1e-07 22.9 In-house 237-314 (440) alignment 
Range on Protein: 125-206
Range on HMM: 237-314/440.0
QFISTQGPIKNTIADFWHMVYTEKCHVIVMLCQYieeDQEKCQRYFS-DTSEKEYGDYRvkVVEKTVELWNPVKVTGIQVQKK
 ||.|| |.  |. ||| .|.  .   |.|| |    ..  |  |.  .|    .| .   |  |  |  | |||  .... |
afiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtfgpft..vghkgsenmnrvkvrtlelkyk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 130-315 5.3e-26 85.8 In-house 80-289 (302) alignment 
Range on Protein: 130-315
Range on HMM: 80-289/302.0
QG-----------------PIKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSE--KEYGDYRVKVVEKTVELWNP-----VKVTG--IQV
||                 | |.|.  .| ..   .  ..| ||...|....||  |.||  .   ..| | || |.   .| .      .|.    |. 
qGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveikn

QKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVlnKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQY
.||.  .|. |    .  | |  || .. . ... |    .|  | ..|||||||||| |.| |     .  ..   |...|.. .|. | ||||.. | 
ekkkkkvkktvdilafsawpdhGapkeaytaldilkfc..esykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqql

VYLVVLMIELFI
.||....   ..
iylllcvtkglm
subfamily_hpo-7_pd Subfamily hpo-7 133-335 1.1e-27 91.6 In-house 43-249 (263) alignment 
Range on Protein: 133-335
Range on HMM: 43-249/263.0
IKNTIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVELwNPVKVTGIQVQ-KKNCPTKHMVYHYFYYDWHDQVAPLDP
. .||. |....   | .|.|||| . ||..|||..||    ..      |.|.   |   .... |   ..  ..  . | | ||.|  | .. .| ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpela

APMIKMYKAVLNksSsKPIVVHCSAGVGRTSTFVGI-YLSQIMIR-----ENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIELFIDDKI-IKRNA
  .... |.. |  | |..|||||.|.||.. |. .  . | |||     .   .| ...|. || .| .|..  .|  . ...........      .|
reilnilkvarn..s.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgelea

NYESLLKKYAD
.|. . | |  
kyqeirksylh
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 136-311 6.6e-10 32.1 In-house 130-306 (346) alignment 
Range on Protein: 136-311
Range on HMM: 130-306/346.0
TIADFWHMVYTEKCHVIVMLCQYiEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVELWNPVKVTGIQVQKKNCPTKHMVYHYFYYDWHDQVAPLDPAPMI
 . |||.|.| |. |.. ..    .  ..     | |         .. . ..  ..    |   |.|  .      ..  . .  |.    |    |.|
fvedfwymiyqeqihlvylmvpd.dklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpii

KMYKAVLNKSS--SKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMI
|| .  | .    .  . |    | ||. .|.|   .   . .    ...||.| ..  | |.|.|  ||  .  ...
kmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf
DUF2663 Protein of unknown function (DUF2663) 136-194 3.1e-06 13.9 Pfam-A 46-104 (130) alignment 
Range on Protein: 136-194
Range on HMM: 46-104/130.0
TIADFWHMVYTEKCHVIVMLCQYIEEDQEKCQRYFSDTSEKEYGDYRVKVVEKTVELWN
. . . ... .........|   .   . .  .  .. .|||| . |  ..|| ..||.
steellsallassvylllllllalayitavylkkKeeKaEkeyhaLRcEiiekSkdlWk
0048179 (Phosphotyrosine protein) phosphatases II 208-307 6.5e-21 70.0 In-house 43-138 (144) alignment 
Range on Protein: 208-307
Range on HMM: 43-138/144.0
CPTKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK-SSSKPIVVHCSAGVGRTSTFVGIYlsqIMIRENssVDMVEILKRLRTMRLGAVQSQLQYVYL
   ......|....|.|  .| ... ........ .  ....|..|||||||||| |.| .|   .|....  ... |.|...|..| |||... |. .|
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay...lmkklg..lsleealalvrsrrpgavpnpgqlrfL

V
 
l
0048076 (Phosphotyrosine protein) phosphatases II 210-313 1e-21 72.6 In-house 43-142 (145) alignment 
Range on Protein: 210-313
Range on HMM: 43-142/145.0
TKHMVYHYFYYDWHDQVAPLDPAPMIKMYKAVLNK-SSSKPIVVHCSAGVGRTSTFVGIYlsqIMIRENssVDMVEILKRLRTMRLGAVQSQLQYVYLVV
 ......|.|..| |  .| ... ........ .  .. .|..|||||||||| |.|..|   .|....  |.. |.|...|..| |||... |. .|  
lerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay...lmlllg..vsleealelvrsqrpgavpnpgqlrflye

LMIEL
.  ||
felel
0048567 (Phosphotyrosine protein) phosphatases II 212-269 1.6e-07 25.9 In-house 38-99 (157) alignment 
Range on Protein: 212-269
Range on HMM: 38-99/157.0
HMVYHYFYYDWHdqvaPLDPAPMIKMYKAVLNKS-----SSKPIVVHCSAGV---GRTSTFVGIYL
 .||. |..|.     ||. |  .. .. . ..       .|.|.|||.||    ||| |..| ||
glvyedfffdfG....PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 213-304 1.7e-08 28.5 In-house 216-334 (350) alignment 
Range on Protein: 213-304
Range on HMM: 216-334/350.0
MVYHYFYYDWHDQVAPLDPAPMIKMYK------------AVLNKSSSKPIVVHCSAGVGRTSTFVGIY--LSQIM----IRE--------NSSVDMVE-I
.||.  .  |.|    |.|  .... .              |... |.||.|||||||||| |.| .   ||..     ...        .   |... |
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LKRLRTMRLGAVQSQLQYV
...||  |.  ||.  |..
vnelrkqrismvqnldqfi
subfamily_PTPDC1_pd Subfamily PTPDC1 213-303 5.3e-07 24.2 In-house 82-165 (182) alignment 
Range on Protein: 213-303
Range on HMM: 82-165/182.0
MVYHYfYYDWHDQVAPlDPAPMIKMYKAVLNKSSSKPIVVHCSAGVGRTSTFVGIYLsqIMIRensSVDMVEILKRLRTMRLGAVQSQLQY
 .|.|  . |.|  ..     .. . | |    . . . ||| || |||   .  ||  .  .   ...  . .| .|  |  ..|.. | 
giyvy.nfgwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliacyl..vyak...rltaekaiklvrskrpksiqtreqv
PTPc_DSPc_SM00012 214-310 7.4e-26 85.8 In-house 2-103 (105) alignment 
Range on Protein: 214-310
Range on HMM: 2-103/105.0
VYHYFYYDWHDQVAPLDPAPMIKMYKAVLNKSS----SKPIVVHCSAGVGRTSTFVGIYLSQIMIREN-SSVDMVEILKRLRTMRLGAVQSQLQYVYLVV
|.|| |..| |. .| .. ..... .|| .. .    |||.||||||||||| ||| ...   ..... ..||. .|.|.||..| |.||.. ||..|  
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LM
 .
al
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 214-321 1.5e-10 35.0 In-house 91-202 (440) alignment 
Range on Protein: 214-321
Range on HMM: 91-202/440.0
VYHYFYYDWHDQVAPLDPAPMIKMYKAVL---NKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLM
. .|.|  | |.  |   .|..|| . |    .|... |..||||||.|||.  . .       . .  .|.. ... .|  |   ||.  ||...   .
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

IE-LFIDDKIIK
.| |.. | .| 
legllcgdtlil
0038934 (Phosphotyrosine protein) phosphatases II 219-307 9.5e-12 40.4 In-house 69-170 (194) alignment 
Range on Protein: 219-307
Range on HMM: 69-170/194.0
YYD---------------WHDQVAPLDP---APMIKMYKAVLNKSSSKPIVVHCSAGVGRTSTFVGIYLsqiMIRENSsvDMVEILKRLRTMRLGAVQSQ
|||               . |. .. .       ... . .||..... ..||| ||.||| |.|. ||   . | .   .. | ....| .| ||...|
yYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL...iyrlgm..saeeAialfrekRpgaipnq

LQYVYLV
 .. .|.
dyleall
subfamily_PTEN_pd Subfamily PTEN 232-307 1.3e-08 30.0 In-house 99-175 (184) alignment 
Range on Protein: 232-307
Range on HMM: 99-175/184.0
APMIKMYKAVLNKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSvDMVEILKRLRTMRLGAV--QSQLQYVYLV
.....  .. |...... .|||| || ||| . .  || .... |... ...|. .. ||    .|   ||. ||. .
eeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqrRYveYy
subfamily_CDC14_pd Subfamily CDC14 233-306 1.6e-07 25.5 In-house 250-316 (328) alignment 
Range on Protein: 233-306
Range on HMM: 250-316/328.0
PMIKMYKAVLNKSsSKPIVVHCSAGVGRTSTFVGIYLsqimIReNSSVDMVEILKRLRTMRLGAVQSQlQYVYL
 ..| . ....|. .  |.||| ||.||| |... ||    .. .  .   |..  || .| | | .. |  .|
aivkkfleiaeka.eGaiavhCkaGLGrtGtLiacyl....mk.hyrftaaeaiawlricrPGsvigp.qqkfl
subfamily_PRL_pd Subfamily PRL 235-303 5.8e-06 20.4 In-house 78-141 (151) alignment 
Range on Protein: 235-303
Range on HMM: 78-141/151.0
IKMYKAVLNKSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVeilkrlRTMRLGAVQ-SQLQY
... |.  ...... . ||| ||.||.  .| . | .  .. . .|...      |. | ||.   ||..
lellkekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefi......rekrrgainskqlkf
PTEN_1 236-305 1.2e-08 30.0 In-house 115-186 (196) alignment 
Range on Protein: 236-305
Range on HMM: 115-186/196.0
KMYKAVLNK----SSSKPIVVHCSAGVGRTSTFVGIYLSQIMIreNSSVDMVEILKRLRTMRLGAVQSQLQYVY
.. | . .     .. . ..||| ||.||. | |  || . .    .  . .|.... |. .     || ....
dicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk..ltadeAlelvrekRppgapnspsqerlle
PTPc_motif_SM00404 241-304 6.2e-07 24.4 In-house 72-131 (140) alignment 
Range on Protein: 241-304
Range on HMM: 72-131/140.0
VLN--KSSSKPIVVHCSAGVGRTSTFVGIYLsqIMIRENSSVDMVEILkrlRTMRlGAVQSQLQYV
...  ... . ..||| ||| |. |..  ||  .. |. |  . .|..   .  |  ... .|..|
fienaekkggkvlVHCqaGvSRSatliiaYl..mryrqlslaeayefv...kerR.piispnlnfv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 241-270 2.4e-06 21.1 In-house 259-290 (349) alignment 
Range on Protein: 241-270
Range on HMM: 259-290/349.0
VLNKSSSKPIVVHCSAGVGRTSTFVGIYL--S
 |... . ...|||||| ||| ..| . |  |
yldtdqlstllvhcsaGcGrtGvlvtldllls
subfamily_CG42327_pd Subfamily CG42327 244-307 2e-09 31.5 In-house 244-310 (319) alignment 
Range on Protein: 244-307
Range on HMM: 244-310/319.0
KSSSKPIVVHCSAGVGRTSTFVGIYLSQIMIREN-SSVDMVEILKRLRTMRLGAVQSQLQYVYL--V
..|  |.||||| ||||| . .   ..   . |.  |||. ...  .|  |  ||... || ..  |
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
DSPc Dual specificity phosphatase, catalytic domain 244-291 6.7e-07 24.3 Pfam-A 70-115 (133) alignment 
Range on Protein: 244-291
Range on HMM: 70-115/133.0
KSSSKPIVVHCSAGVGRTSTFVGIYLsqiMIRENSSV-DMVEILKRLRT
... | ..||| ||. |. |..  ||   | ..| |. . .|..|. | 
eqkgkkvlVHCqaGisRSatliiaYl...mktknlslneAyefvkerrs
DSPc Dual specificity phosphatase, catalytic domain 244-291 6.7e-07 24.3 In-house 70-115 (133) alignment 
Range on Protein: 244-291
Range on HMM: 70-115/133.0
KSSSKPIVVHCSAGVGRTSTFVGIYLsqiMIRENSSV-DMVEILKRLRT
... | ..||| ||. |. |..  ||   | ..| |. . .|..|. | 
eqkgkkvlVHCqaGisRSatliiaYl...mktknlslneAyefvkerrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 247-307 7.2e-07 23.4 In-house 228-288 (297) alignment 
Range on Protein: 247-307
Range on HMM: 228-288/297.0
SKPIVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLV
. ...|||||||||.   |       ..| .   |.  ||. ||  |   ||.  |. .| 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfelly
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 250-307 1.1e-07 26.2 In-house 1-58 (69) alignment 
Range on Protein: 250-307
Range on HMM: 1-58/69.0
IVVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLV
.|||||.| ||| ||. | .    |. .  ||. . .. .|  |   |  . .|... 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifih
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 251-307 6.5e-07 23.6 In-house 1-57 (69) alignment 
Range on Protein: 251-307
Range on HMM: 1-57/69.0
VVHCSAGVGRTSTFVGIYLSQIMIRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLV
|||||.| ||| ||. | .    |. .  ||. . .. .|  |   |  . .|... 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfih
Peptidase_C74 Pestivirus NS2 peptidase 267-350 1.7e-06 13.7 Pfam-A 23-106 (200) alignment 
Range on Protein: 267-350
Range on HMM: 23-106/200.0
IYLSQImiRENSSVDMVEILKRLRTMRLGAVQSQLQYVYLVVLMIEL--FIDDKIIKRNANYESLLKKYADVTRKVTAAIMEEEEK
.||     ...|.  .  .|  |... .  . |. |.|||. |..||  ..  |||.. |    || .      ... |. ||| |
vylfps..kqksrsktdallpllkavliscisskwqvvyllylvlelvyylhrkiieeiaggtnllsrliaalielnwaldeeesk
Peptidase_S49_N Peptidase family S49 N-terminal 304-377 2.8e-06 15.1 Pfam-A 22-95 (155) alignment 
Range on Protein: 304-377
Range on HMM: 22-95/155.0
VYLVVLMIELFIDDKIIKRNANYESLLKKYADVTRKVTAAIMEEEEKRRQRKKREeEKEKEQEKESP-ATKEEKK
| .|||...|   .|  | . . ..| ..| ........|....||.....|... ..|||..|..  ..|....
vvvvvlivalakkkkkkkgeleitklneeykelkeeleealldkeelkalekeek.keekekkkaekkkakkaee