Gene tensin in Caenorhabditis elegans

Synonym: CELE_F46F11.3, tag-83

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP191_AA protein Get Run
CeleP191_AA_2-170 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 3-185 5.2e-80 260.4 In-house 6-189 (189) alignment
Range on Protein: 3-185
Range on HMM: 6-189/189.0
DRKEGVQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISS-SLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLN
..|......|||.|.|.||...|..|.|..|.| .........||....|.|.|..|.|||. . ....||||...||||||||.|||.||.|. ..| |
eekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqn

IAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGPPSYKRYLGYFSSLLSGRISVNSDPLYLHNIIL
..|..|||| .|...||.|.|....|||..|.. |||.|.||....| ... ||..||. |||.||||.| .||.||.|| .||
vvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil

PTEN_1 3-169 1.7e-28 94.8 In-house 15-194 (196) alignment
Range on Protein: 3-169
Range on HMM: 15-194/196.0
DRKEGVQVEYITSRLIVLSCTSET------SERKFVESLLKASQQIQNAHNKH-IRVWNVSQRRHD----------ISSSLDAIPFGWPSETAPSLEKLC
...| ... |||||.|. .... .      .|.....||. ...  .| . ..   |.|.| ....          . | .  ..|...  .||||..|.
lptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslself

TICKNLDQWMLEHP-LNIAVIFCKGGLERCAIVVNAFMRFNAIsatdDSVDDRFSMQRFSERFLGPDgPPSYKRYLGYFSSLLSG
 |||....|.|..|  |.....||.|| |.. || |.. .       ...|. ... |    . .|  .|| .|.| ||..||..
dicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk....ltadeAlelvrekRppgapn.spsqerlleyfaellae

subfamily_Auxilin_pd Subfamily Auxilin 5-168 1.6e-28 92.5 In-house 6-165 (166) alignment
Range on Protein: 5-168
Range on HMM: 6-165/166.0
KEGVQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISS-SLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIA
|. . . |||||.||.|. .|  |  .  ..   .. ..  | ..  |.|.||| .. .  |   .  ||| . ||.||.| ..|.||..|. . | |. 
kndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvv

VIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERflgpdGPPSYKRYLGYFSSLLS
|. || |    |..| |.. |  .  . .|  . ||..| ..        || |||| |.. ||.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla

subfamily_PTEN_pd Subfamily PTEN 8-168 2.1e-21 71.7 In-house 20-180 (184) alignment
Range on Protein: 8-168
Range on HMM: 20-180/184.0
VQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNV-SQRRHDISSSLDAI-PFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVI
. . |||...|...  .|. |. .  || .  . ... |..| ...|. |.|..| ..  . .  ..   ...|.|| | .|......|. | . |..|.
LDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvv

FCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERfLGPDgPPSYKRYLGYFSSLLS
 || |  |  ... |..  . .  . ... . |. .|....  |    || .||. |...||.
HCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.kgvt.iPsqrRYveYyeklle

subfamily_VSP_pd Subfamily VSP 9-166 5.7e-15 49.8 In-house 35-197 (212) alignment
Range on Protein: 9-166
Range on HMM: 35-197/212.0
QVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNV-SQRRHDISSSLDAI-PFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVIF
.. |.| |.|  |  |   .  . . . . .. ... |..| .| |. |.| .| .   . .          |.||.| ...|.. .|. . . |. .| 
dltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlaih

CKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQR----FSERFLGPDGpPSYKRYLGYFSSL
|||| .|   .| |..    |  | .   | |. .|     .|.| | .  || |||.||.  .
ckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqt.psqkryvgyleqv

0036282 (Phosphotyrosine protein) phosphatases II 11-170 7.2e-13 44.1 In-house 13-172 (174) alignment
Range on Protein: 11-170
Range on HMM: 13-172/174.0
EYITSRLIVLSCTSEtserkFV--------ESLLKASQQIQNAHNKHIRVWNVsQRRHDISSSLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLNI
 |||.|||. ..  .     |.        ....   . ... . | |. |.   | .   . .  . ..||  ..|.|..|....| ......|.| . 
syitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

AVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSerFLGPDGPPSYKRYLGYFSSLLSGR
 .. |..|. | ...| |..    .  . . . | . ..|.   . |    ||. |.| ||..||||.
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgs

0038934 (Phosphotyrosine protein) phosphatases II 12-124 2.7e-07 25.9 In-house 15-139 (194) alignment
Range on Protein: 12-124
Range on HMM: 15-139/194.0
YITSRLIVLSCTSETSERKFVESLLKAS-------QQIQNAHNKHIRVWNVSQRRHDISSS----LDAIPFGWPS-ETAPSLEKLCTICKNLDQWMLEHP
.|| |.|...  .. | .|..|.|.. |        . .| .. ..  .. . |  | .      .. . . .|.  |.|||| |..... .|... |.|
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

LNIAVIFCKGGLERCAIVVNAFMRF
 .. .. ||.|| | ...| |..  
ggvvaVHCkaGlgRtGtlvaaYLiy

SH2 SH2 domain 1173-1262 8e-14 42.1 Pfam-A 1-77 (77) alignment
Range on Protein: 1173-1262
Range on HMM: 1-77/77.0
WYKPTISREQAINMLRD-KPPGTFVVRDSNSFPGAFGLALKVSTpppgvnpgdgseLVRHFLIEPSPKGvKLKGCNNEPvFGSLSALVYQH
||   ||||.| ..|.. |..|||.||.|.|.|| . |... .              |.|. |. . .| |.   .||  | ||. ||. .
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg............kvkhyriqsleng.kyyitenek.fsslqeLvehY

PTB Phosphotyrosine-binding domain 1299-1443 1.5e-46 146.5 Pfam-A 1-131 (131) alignment
Range on Protein: 1299-1443
Range on HMM: 1-131/131.0
ACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFrRHFNVQSVIFAGMDPIERRFENtralgfhdgciaqar
...|... .||..||||.|.|...||........|...|..|..|||.||||||||.|| .. ......||... ... |||.|.               
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes...............

LFAFVARIPSSSENACHVFA--ELEPEQPGSAVVNFINKVMLAQKNR
|.|.||| |.||..  |.|.  |||.||. ........||.|..|.|
llalvarepesskenvhlFqcdeleaeqiaediekalskvklgkkkr

PID_2 Phosphotyrosine interaction domain (PTB/PID) 1301-1356 7.1e-06 12.1 Pfam-A 3-57 (182) alignment
Range on Protein: 1301-1356
Range on HMM: 3-57/182.0
NVVYVGSVDVESLTGNECVKRSIATCSQRAINGDsRAVSVHFKVSSQGVTLTDNTR
.|||.| |      |..||.....|  ..  ..    .....||...|...| . .
kvvyLGnvltllakGegcvdkalstiWkkyeekk.sdlkmklkvtasGlkattkek

PID Phosphotyrosine interaction domain (PTB/PID) 1302-1418 1.8e-06 14.4 Pfam-A 3-114 (140) alignment
Range on Protein: 1302-1418
Range on HMM: 3-114/140.0
VVYVGSVDVESL----------TGNECVKRSIAT---CSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRrHFNVQSVIFAGM-DPI-ERRFENtra
| |.|||.| .             .|...|  .     ...  .   . .... ..|..|..|.|.  |     ....... |..  |.  ||||     
vkylGsvevleerapdkstrmqvaqeaisrvkeaklkkikkkegerqkgteidLeistdglklldektkevla.dhplrkIsfiadgdvdderrfay...

lgfhdgciaqarlfafVARIPSSSENACHVFA
                .|. . ... ||||| 
................iaadkktnkfaChvFe