Gene tensin in Caenorhabditis elegans

Synonym: CELE_F46F11.3, tag-83

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP191_AA protein Get Run
CeleP191_AA_2-170 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Tensin_pd Subfamily Tensin 3-185 5.2e-80 260.4 In-house 6-189 (189) alignment 
Range on Protein: 3-185
Range on HMM: 6-189/189.0
DRKEGVQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISS-SLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLN
..|......|||.|.|.||...|..|.|..|.| .........||....|.|.|..|.|||. . ....||||...||||||||.|||.||.|. ..| |
eekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqn

IAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGPPSYKRYLGYFSSLLSGRISVNSDPLYLHNIIL
..|..|||| .|...||.|.|....|||..|.. |||.|.||....| ... ||..||. |||.||||.| .||.||.|| .||
vvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil
PTEN_1 3-169 1.7e-28 94.8 In-house 15-194 (196) alignment 
Range on Protein: 3-169
Range on HMM: 15-194/196.0
DRKEGVQVEYITSRLIVLSCTSET------SERKFVESLLKASQQIQNAHNKH-IRVWNVSQRRHD----------ISSSLDAIPFGWPSETAPSLEKLC
...| ... |||||.|. .... .      .|.....||. ...  .| . ..   |.|.| ....          . | .  ..|...  .||||..|.
lptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslself

TICKNLDQWMLEHP-LNIAVIFCKGGLERCAIVVNAFMRFNAIsatdDSVDDRFSMQRFSERFLGPDgPPSYKRYLGYFSSLLSG
 |||....|.|..|  |.....||.|| |.. || |.. .       ...|. ... |    . .|  .|| .|.| ||..||..
dicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk....ltadeAlelvrekRppgapn.spsqerlleyfaellae
subfamily_Auxilin_pd Subfamily Auxilin 5-168 1.6e-28 92.5 In-house 6-165 (166) alignment 
Range on Protein: 5-168
Range on HMM: 6-165/166.0
KEGVQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISS-SLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIA
|. . . |||||.||.|. .|  |  .  ..   .. ..  | ..  |.|.||| .. .  |   .  ||| . ||.||.| ..|.||..|. . | |. 
kndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvv

VIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERflgpdGPPSYKRYLGYFSSLLS
|. || |    |..| |.. |  .  . .|  . ||..| ..        || |||| |.. ||.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla
subfamily_PTEN_pd Subfamily PTEN 8-168 2.1e-21 71.7 In-house 20-180 (184) alignment 
Range on Protein: 8-168
Range on HMM: 20-180/184.0
VQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNV-SQRRHDISSSLDAI-PFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVI
. . |||...|...  .|. |. .  || .  . ... |..| ...|. |.|..| ..  . .  ..   ...|.|| | .|......|. | . |..|.
LDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknvvvv

FCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERfLGPDgPPSYKRYLGYFSSLLS
 || |  |  ... |..  . .  . ... . |. .|....  |    || .||. |...||.
HCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.kgvt.iPsqrRYveYyeklle
subfamily_VSP_pd Subfamily VSP 9-166 5.7e-15 49.8 In-house 35-197 (212) alignment 
Range on Protein: 9-166
Range on HMM: 35-197/212.0
QVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNV-SQRRHDISSSLDAI-PFGWPSETAPSLEKLCTICKNLDQWMLEHPLNIAVIF
.. |.| |.|  |  |   .  . . . . .. ... |..| .| |. |.| .| .   . .          |.||.| ...|.. .|. . . |. .| 
dltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvlaih

CKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQR----FSERFLGPDGpPSYKRYLGYFSSL
|||| .|   .| |..    |  | .   | |. .|     .|.| | .  || |||.||.  .
ckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqt.psqkryvgyleqv
0036282 (Phosphotyrosine protein) phosphatases II 11-170 7.2e-13 44.1 In-house 13-172 (174) alignment 
Range on Protein: 11-170
Range on HMM: 13-172/174.0
EYITSRLIVLSCTSEtserkFV--------ESLLKASQQIQNAHNKHIRVWNVsQRRHDISSSLDAIPFGWPSETAPSLEKLCTICKNLDQWMLEHPLNI
 |||.|||. ..  .     |.        ....   . ... . | |. |.   | .   . .  . ..||  ..|.|..|....| ......|.| . 
syitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

AVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSerFLGPDGPPSYKRYLGYFSSLLSGR
 .. |..|. | ...| |..    .  . . . | . ..|.   . |    ||. |.| ||..||||.
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgs
0038934 (Phosphotyrosine protein) phosphatases II 12-124 2.7e-07 25.9 In-house 15-139 (194) alignment 
Range on Protein: 12-124
Range on HMM: 15-139/194.0
YITSRLIVLSCTSETSERKFVESLLKAS-------QQIQNAHNKHIRVWNVSQRRHDISSS----LDAIPFGWPS-ETAPSLEKLCTICKNLDQWMLEHP
.|| |.|...  .. | .|..|.|.. |        . .| .. ..  .. . |  | .      .. . . .|.  |.|||| |..... .|... |.|
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

LNIAVIFCKGGLERCAIVVNAFMRF
 .. .. ||.|| | ...| |..  
ggvvaVHCkaGlgRtGtlvaaYLiy
SH2 SH2 domain 1173-1262 8e-14 42.1 Pfam-A 1-77 (77) alignment 
Range on Protein: 1173-1262
Range on HMM: 1-77/77.0
WYKPTISREQAINMLRD-KPPGTFVVRDSNSFPGAFGLALKVSTpppgvnpgdgseLVRHFLIEPSPKGvKLKGCNNEPvFGSLSALVYQH
||   ||||.| ..|.. |..|||.||.|.|.|| . |... .              |.|. |. . .| |.   .||  | ||. ||. .
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg............kvkhyriqsleng.kyyitenek.fsslqeLvehY
PTB Phosphotyrosine-binding domain 1299-1443 1.5e-46 146.5 Pfam-A 1-131 (131) alignment 
Range on Protein: 1299-1443
Range on HMM: 1-131/131.0
ACNVVYVGSVDVESLTGNECVKRSIATCSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFrRHFNVQSVIFAGMDPIERRFENtralgfhdgciaqar
...|... .||..||||.|.|...||........|...|..|..|||.||||||||.|| .. ......||... ... |||.|.               
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes...............

LFAFVARIPSSSENACHVFA--ELEPEQPGSAVVNFINKVMLAQKNR
|.|.||| |.||..  |.|.  |||.||. ........||.|..|.|
llalvarepesskenvhlFqcdeleaeqiaediekalskvklgkkkr
PID_2 Phosphotyrosine interaction domain (PTB/PID) 1301-1356 7.1e-06 12.1 Pfam-A 3-57 (182) alignment 
Range on Protein: 1301-1356
Range on HMM: 3-57/182.0
NVVYVGSVDVESLTGNECVKRSIATCSQRAINGDsRAVSVHFKVSSQGVTLTDNTR
.|||.| |      |..||.....|  ..  ..    .....||...|...| . .
kvvyLGnvltllakGegcvdkalstiWkkyeekk.sdlkmklkvtasGlkattkek
PID Phosphotyrosine interaction domain (PTB/PID) 1302-1418 1.8e-06 14.4 Pfam-A 3-114 (140) alignment 
Range on Protein: 1302-1418
Range on HMM: 3-114/140.0
VVYVGSVDVESL----------TGNECVKRSIAT---CSQRAINGDSRAVSVHFKVSSQGVTLTDNTRKVFFRrHFNVQSVIFAGM-DPI-ERRFENtra
| |.|||.| .             .|...|  .     ...  .   . .... ..|..|..|.|.  |     ....... |..  |.  ||||     
vkylGsvevleerapdkstrmqvaqeaisrvkeaklkkikkkegerqkgteidLeistdglklldektkevla.dhplrkIsfiadgdvdderrfay...

lgfhdgciaqarlfafVARIPSSSENACHVFA
                .|. . ... ||||| 
................iaadkktnkfaChvFe