Gene vhp-1 in Caenorhabditis elegans

Synonym: CELE_F08B1.1, vhp-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP8
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP195_AA protein Get Run
CeleP195_AA_173-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 23-144 3.9e-08 25.8 Pfam-A 12-112 (113) alignment 
Range on Protein: 23-144
Range on HMM: 12-112/113.0
DTTLVVDCRGFTEYNESHVRHSMNAFFSKLirrrlfenklddnclihqlmsCSSGCTKMDEKLDLVLYAEEDKPRGNKRRIASCNAPESTAKIMRVLRER
.. ...|.| . ||...|.. ..|  .. |                     ....  ....||   |   . |   .|. .  |.  ....   ..|.. 
ekvvllDvRspeeyakghIpgAvnvpldsl.....................yprrdlffkdklaeeleesgkkldkdktvvvycrsgnrsggaaalllal

-LEDtDKFRSVMVLEGGFKQFAQ
 |.    .  | ||.|||.....
ilke.lgyknvyvLdGGfeawka
Subfamily.CDC25.PD 23-147 1.6e-06 19.5 In-house 13-116 (117) alignment 
Range on Protein: 23-147
Range on HMM: 13-116/117.0
DTTLVVDCRGFTEYNESHVRHSMNAFFSKLIRRRLFENKLDDnclihqlmscssgcTKMDEKLDLVLYAEEDKPRGNKRRiascnapESTAKIMRVLRER
..  ..|||   ||.  |.. ..|.. .. .........                 .. ...  .... |  . || |         .   .. | | ..
ekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvk..............aseekrtivifhCefSseRgPkla.......rllrevdrelnke

LEDTDKFRSVMVLEGGFKQFAQQYP
   . ..  . .||||.|.| ....
eypkleypelylLegGykeffeeve
Family.CDC25.PD 23-147 1.6e-06 19.5 In-house 13-116 (117) alignment 
Range on Protein: 23-147
Range on HMM: 13-116/117.0
DTTLVVDCRGFTEYNESHVRHSMNAFFSKLIRRRLFENKLDDnclihqlmscssgcTKMDEKLDLVLYAEEDKPRGNKRRiascnapESTAKIMRVLRER
..  ..|||   ||.  |.. ..|.. .. .........                 .. ...  .... |  . || |         .   .. | | ..
ekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvk..............aseekrtivifhCefSseRgPkla.......rllrevdrelnke

LEDTDKFRSVMVLEGGFKQFAQQYP
   . ..  . .||||.|.| ....
eypkleypelylLegGykeffeeve
Group.Cx5R-II.PD 23-147 1.6e-06 19.5 In-house 13-116 (117) alignment 
Range on Protein: 23-147
Range on HMM: 13-116/117.0
DTTLVVDCRGFTEYNESHVRHSMNAFFSKLIRRRLFENKLDDnclihqlmscssgcTKMDEKLDLVLYAEEDKPRGNKRRiascnapESTAKIMRVLRER
..  ..|||   ||.  |.. ..|.. .. .........                 .. ...  .... |  . || |         .   .. | | ..
ekyiiiDcRypyeyegGHikgavnlysreeleeeflkepkvk..............aseekrtivifhCefSseRgPkla.......rllrevdrelnke

LEDTDKFRSVMVLEGGFKQFAQQYP
   . ..  . .||||.|.| ....
eypkleypelylLegGykeffeeve
0042113 (Phosphotyrosine protein) phosphatases II 160-318 8.6e-25 83.0 In-house 20-244 (245) alignment 
Range on Protein: 160-318
Range on HMM: 20-244/245.0
PQSLSQPCLSQPTGD-----------GITLITPNIYLGSQIDSLDET----MLDALDISVVINLSMTCP-------------------------------
|   .. .|| . ||           .   |||.......  . .      ||  |.|.....|. . .                               
pydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehl

-------------KSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRR--AGKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVK
             .. . .|. .....|. |     |. ..  ..||..|...  .....|.|| ||..|. |... |.|     .....  ..|.....
ddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelr

ERRPSISPNFNFMGQLLEYENVLIK
..|| . ...... .| |..  |.|
sqRpgavqtpsqyrflyeallellk
subfamily_DSP8_pd Subfamily DSP8 162-320 4.8e-74 241.2 In-house 2-158 (159) alignment 
Range on Protein: 162-320
Range on HMM: 2-158/159.0
SLSQPCLSQPTgDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKnFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIH
.|||||||... .|.| |..|.||||| |.|.|..|..|.||.|.|.|..|||. ..||.| |.|.||.|.|.|||.|.|....||..|.... ...|.|
elsqPCLsvad.vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvh

CLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDH
.|||||||.|.||.|||....|..|.|||.|||.||.||||.||.|||||||. | ...
vlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt
subfamily_DSP1_pd Subfamily DSP1 172-317 4.5e-39 128.1 In-house 14-157 (163) alignment 
Range on Protein: 172-317
Range on HMM: 14-157/163.0
TGDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVciKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPT
. | .. |.. .||||.... .  .|..|.|. ..|.| ....    ..  ........|| .. .| .|  . ||........ | |||| |||||| |
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvf..edlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsst

LAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLI
| . |.|.  ..  ..|. .||.||. ||||..|..|||.||. | 
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
0044763 (Phosphotyrosine protein) phosphatases II 173-317 1.8e-38 127.3 In-house 20-171 (178) alignment 
Range on Protein: 173-317
Range on HMM: 20-171/178.0
GDGITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTC-------PKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCR-RAGKKCLIHCLA
. ... |.|..||||. .. |  .| .|.|....||. ..       ..  . ... ....||. |.    |. .|. ..||.|... . |...|.|| |
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsa

GISRSPTLAISYIMRYMKMGSDDAYRYVKERRPsISPNFNFMGQLLEYENVLI
|..||.||.. |.|.....  ..|...|.|||| |.||.... ||.|.|  | 
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
0041856 (Phosphotyrosine protein) phosphatases II 173-319 7.4e-32 105.8 In-house 16-175 (182) alignment 
Range on Protein: 173-319
Range on HMM: 16-175/182.0
GDGITLITPNIYLGSQID--------------SLDETMLDALDISVVINLSmtCPK---SVCIKEDKNFMRIPVNDSYQEKlspyFPMAYEFLEKCRRAG
. ... |..|.||||. .                . .||  |.|....||.  ..    . . ..  .....|. |         ......|.|.... |
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeg

KKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRP--SISPNFNFMGQLLEYENVLIKD
...|.|| ||..|..||.. |.|...... ..|...|..|||   |.||..|. ||...| .| |.
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP14_pd Subfamily DSP14 174-318 3.7e-36 118.4 In-house 5-146 (157) alignment 
Range on Protein: 174-318
Range on HMM: 5-146/157.0
DGITLITPNIYLGsQIDSLDETMLDALDISVVINLSMTCPKsVCIkEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLA
 ... |||...|.    .|....|..  |...||...  |.   . .| . ...||.|. ..||...| .... .|. ...| |.|.|| ||.||| .|.
aalsqitpsLfls.gvaalskellkkkkitliinvtvelpn.tkl.kdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

ISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
. |.|.| |.   .||..||..|| |.||  |  || .||. | .
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
0046846 (Phosphotyrosine protein) phosphatases II 174-318 4.8e-28 93.5 In-house 10-174 (176) alignment 
Range on Protein: 174-318
Range on HMM: 10-174/176.0
DGITLITPNIYLGSQI----------DSLDETMLDALDISVVINLSMTC---------PKSVCIKEDKNFMRIPVNDSYQEKLsPYFPMAYEFLEKCRRA
 ... |..|..|||               .  ||  |.|..|.||               ... |..  ....|. |     |  ... ..||.......
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke

GKKCLIHCLAGISRSPTLAISYIMRY-MKMGSDDAYRYVKERRP-SISPNFNFMGQLLEYENVLIK
|.. |.|| |||.|..||.. |.... . .  ..|...|.|.||  . ...... .| |.|  |.|
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
PTEN_1 174-314 4.9e-25 83.5 In-house 42-189 (196) alignment 
Range on Protein: 174-314
Range on HMM: 42-189/196.0
DgitLITPNIYLGSQIDS-LDETMLDALDISVVINLSMTCPK-------SVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRR--AGKKCLIHCL
.    | .. |.||. |   |  .|.. .|  |.|||  ..        . ..|.. .. ..|..|     ||  | ....| | ...   |...|.|| 
q...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCk

AGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYEN
||..|| |....| |...|.  |.| ..|.|.|| ..||  .. .||||..
aGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfa
subfamily_DSP10_pd Subfamily DSP10 176-320 3e-50 164.2 In-house 14-157 (159) alignment 
Range on Protein: 176-320
Range on HMM: 14-157/159.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIkEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAIS
.. . | ..|||. |. |...|| |.|..|.|.  ..|.     |. ...||||.|.....|. ||  |.||.|. |. |.. |.|| |||||| |..|.
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDH
|.|.....   |||..|||.|| ||||.||||||||.|. | |..
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
PTPc_motif_SM00404 176-314 7e-45 147.3 In-house 2-139 (140) alignment 
Range on Protein: 176-314
Range on HMM: 2-139/140.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSvCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAIS
.. |.|..||||. .. .. .|..|.|..|||........   ........||..|. ..|||.|......|.|.... |.|.|.|| ||.||| ||.| 
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYEN
|.|||...  ..||..||||||.||||.||. ||.|||.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0048179 (Phosphotyrosine protein) phosphatases II 176-315 3.9e-35 116.0 In-house 4-143 (144) alignment 
Range on Protein: 176-315
Range on HMM: 4-143/144.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAIS
.. |.|..||||. ..||  .| .|.|. ||||. ....  ...|  .....|. |     |. ... ..||.|.... |...|.|| ||..|..||.. 
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENV
|.|.....  ..|...|..||| . ||.... .|||||. 
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 176-316 3.8e-34 112.8 In-house 4-142 (145) alignment 
Range on Protein: 176-316
Range on HMM: 4-142/145.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLsmTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAIS
.. |.|..||||. . ||  .|  |.|  |.||  |. .. . ... .....|. |     |. ... ..||.|.....|...|.|| ||..|..||.. 
pseilpglylgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
|.|.....  ..|...|...|| . ||.... .|.|.|  |
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP19_pd Subfamily DSP19 176-316 8.1e-33 107.9 In-house 12-150 (152) alignment 
Range on Protein: 176-316
Range on HMM: 12-150/152.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSvcIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAIS
.. ..|..|||||    |...|.  .|  ..|...  |.     .| ... |.. |  ...|. |.. | .|.|. |..    |.|| ||.|||....|.
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnv..fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
|.|.  ..   .|...|.| ||.|.||  |. || |||. |
ylmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP15_pd Subfamily DSP15 176-319 8.3e-33 107.6 In-house 2-142 (151) alignment 
Range on Protein: 176-319
Range on HMM: 2-142/151.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLSMtcpKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAIS
|. . |..|||  .|| ||..|.  .|. .....     .  . .|...  |...|. . ||| .|  . ||. |||  ....|.|||||.||| ||.. 
iskvlpglylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva

YIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKD
|.|  ....  || . .|..| .  ||| |  || |||.  .|.
YlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_DSP12_pd Subfamily DSP12 176-318 1.4e-28 94.2 In-house 2-145 (155) alignment 
Range on Protein: 176-318
Range on HMM: 2-145/155.0
ITLITPNIYLGSQIDSLDETMLDALDISVVINLSMT-CPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAI
.. |.|..|||.  .  .|..|. |.|. |. .  .  |.    |  ..   |.. |. .| .  ... | .|.|...  ... |.|| ||.||| |. |
vsrilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtivi

SYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
 |.|.. |.  ..|.. ||| .|.|.|| .|. ||  .|.. .|
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
0036282 (Phosphotyrosine protein) phosphatases II 176-315 2e-26 88.1 In-house 12-168 (174) alignment 
Range on Protein: 176-315
Range on HMM: 12-168/174.0
ITLITPNIYLGSQIDSlDETMLDALDISVVINLSMTCPK-------------SVCIKEDKNFMRIPVNDSYQEKLSPyFPMAYEFLEKCRRA--GKKCLI
.. |||....|.   . .  ||  |.|..|..|   ...             . . ... .....|. |     ||  .  ...|.|...    |...|.
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCLAGISRSPTLAISYIMRYMKM-GSDDAYRYVKERR---PSISPNFNFMGQLLEYENV
|| ||..|..||.. |.| .... . .||...|.|.|   | . ...... .| ..| .
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
subfamily_Slingshot_pd Subfamily Slingshot 177-317 1e-28 93.8 In-house 20-158 (169) alignment 
Range on Protein: 177-317
Range on HMM: 20-158/169.0
TLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKsvCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISY
. |   .||||. .. .   |.  ... ..|..  . .    .|. ....| | |. ...| .|.  .|.|.||....| |.|.||  |.||| .  |.|
skifdhvylGsewnasnleelkengveyilnvtkeidn..ffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

IMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLI
 |.  ..  ..|..||||||  | || .|. || ||| .| 
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGile
0037934 (Phosphotyrosine protein) phosphatases II 177-316 6.4e-27 90.1 In-house 40-241 (243) alignment 
Range on Protein: 177-316
Range on HMM: 40-241/243.0
TLITPNIYLGSQ--------IDSLDETMLDALDISVVINLSMTC------------------------------------------PK-SVCIKEDKNFM
. .||.......        ..  .  ||  |.|.|...|  ..                                          .. . . ... ...
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

RIPVND----SYQEKLSPYFPMAYEFLEK-----CRRAGKKCLIHCLAGISRSPTLAISYIMRYM-KMGSDDAYRYVKERRPS-ISPNFNFMGQLLEYEN
..|. |    .  | |  .. ...||.|.     ..  |...|.|| ||..|. ||.. |.| .. ... ..|.....|.||  . ...... .| |.. 
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

VL
 |
el
0045098 (Phosphotyrosine protein) phosphatases II 177-318 1.5e-23 79.1 In-house 23-273 (278) alignment 
Range on Protein: 177-318
Range on HMM: 23-273/278.0
TLITPNIYLGSQI-----------------------------------------DSLDETMLDALDISVVINLSMTC-----------------------
  |||..|||..                                           . .  ||  |.|.|...|                           
seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

---------------------------PKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRR--------------AGKKCLIHCLAGISRSPT
                                  .  ... .| ...  . .. .|  ..||......               |...|.|| ||..|. |
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGt

LAISYIMRYM---KMGSDDAYRYVKERRPS-ISPNFNFMGQLLEYENVLIK
|.. |.|...   ..  ..|.......||  . .|.... .| |..  |..
lvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0051082 (Phosphotyrosine protein) phosphatases II 177-312 1.3e-22 75.5 In-house 9-149 (151) alignment 
Range on Protein: 177-312
Range on HMM: 9-149/151.0
TLITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKE----DKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRA-GKKCLIHCLAGISRSPT
. .|...|....  . .  .|  |.|....||  . .   | .     . ....||. |    .|. .|. . ||||....  ....|.|| ||..|. |
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

LAISYIMRyMKMGSDDAYRYVKERRP-SISPNFNFMGQLLEY
|.. |.|  ...  ..|.......|| .. ||  |. ||...
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP6_pd Subfamily DSP6 178-316 5.7e-45 146.7 In-house 16-154 (158) alignment 
Range on Protein: 178-316
Range on HMM: 16-154/158.0
LITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYI
 |.|..||||. |. .  .|. |.|. |.|.    |.    ... ....||..| ....|. .|| | ||... |.. .|.|.||||||||| |....|.
eilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlayl

MRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
|.....  .||| .||.|...||||||||||||..|. |
mkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0049260 (Phosphotyrosine protein) phosphatases II 178-316 3.1e-28 93.8 In-house 10-149 (152) alignment 
Range on Protein: 178-316
Range on HMM: 10-149/152.0
LITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSV-CIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEK-CRRAGKKCLIHCLAGISRSPTLAIS
 .......|..  . .  ||  |.|.....|   ...   . ..  .....|. |..  .|| .......|.|| ... |...|.|| ||..|..||.. 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

YIMRyMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
|.|. ...  ..|...|.|.|| . ||.... .|.|.|..|
ylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 178-318 5.1e-23 75.5 In-house 122-260 (263) alignment 
Range on Protein: 178-318
Range on HMM: 122-260/263.0
LITPNIYLGSQIDSLDETMLDALDISVvINLSMTCPKSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKkCLIHCLAGISRSPTLAISYI
.| ....||..  . ....|  |...  | |...  . .  |  | ..   ..|  . ..| .|     |.|. |. |   |.|| ||.||| || |||.
eiidklflGgldsannksilkdlgvth.illavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisyl

MRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
|.. ..   .|.  |...|| | ||  |. ||. ||. | .
mkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfc
0049772 (Phosphotyrosine protein) phosphatases II 179-316 4.2e-31 104.2 In-house 155-273 (314) alignment 
Range on Protein: 179-316
Range on HMM: 155-273/314.0
ItpniylgSQIDSLDETMLDaldisvvinlSMTCPKSVCIKEDKNFMRIPVNDsYQEKLSPYFPMAYEFLEKCrRAGKKCLIHCLAGISRSPT-LAISYI
        .. .  |  .|           . ..... . ..  ...|||| | ... |. .|. ..||.|.. ..|.. |.|| ||..|..| ... |.
g.......neptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaayl

MRYMKMGSDDAYRYVKERRPsISPNFNFMGQLLEYENVL
|.....  ..|...|...|| |.||..|. ||..||..|
mkllgvsleealedvrlkRp.inpnpgfieqleqyefil
subfamily_DSP3_pd Subfamily DSP3 179-318 1.9e-25 83.4 In-house 14-159 (162) alignment 
Range on Protein: 179-318
Range on HMM: 14-159/162.0
ITPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSV------CIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRA-GKKCLIHCLAGISRSPT
..|..|.| .  . |.. | .| |  |.| . .  ..|        . . ... ..|.|. . .|| ||  | .|...       | |.|| .|.|||.|
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

LAISYIMRYMKMGSDDAYRYVKERRpSISPNFNFMGQLLEYENVLIK
|.. |.| . ||   .| | |...| .| ||  |. || |... | .
lvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkr
0051429 (Phosphotyrosine protein) phosphatases II 179-314 1.9e-17 59.3 In-house 19-222 (272) alignment 
Range on Protein: 179-314
Range on HMM: 19-222/272.0
ITPNIYLGSQI----DSLDETMLDALDISVVINLSMTC----PKSVCIKEDKNFMRIPVNDSYQEKLSPYF-----------------------------
. |.... |.     .  |   |  |.|.....|  ..     |  .  .. .....|..|.. .  . ..                             
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

-------------------PMAYEFLEKCRRaGKKCLIHCLAGISRSPTLAISYIMRyMKMG--------------SDDAYRYVKERRPSISPNFNFMGQ
                       |.|| ... |...|.|| ||..|. |..  ...  . ..               ..|.......|| . ..  .. .
arevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LLEYEN
|.|.. 
lyeall
0043147 (Phosphotyrosine protein) phosphatases II 180-316 5.9e-30 99.6 In-house 23-160 (172) alignment 
Range on Protein: 180-316
Range on HMM: 23-160/172.0
TPNIYLGSQIDSLDETMLDALDISVVINLSmTC--PKSVCIKEDKNFMRIPVNDSYQEkLSPYFPMAYEFLEK--CRRAGKKCLIHCLAGISRSPTLAIS
 .. ....  .. .  ||  |.|....||  ..  ... . ...  ....|. |     |. ... ..||...  ... |...|.|| ||..|..||.. 
iatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaa

YIMRyMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
|.|. ...  ..|...|.|.|| ...|.... .|...|. |
ylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_STYXL1_pd Subfamily STYXL1 180-318 2e-22 73.1 In-house 16-155 (157) alignment 
Range on Protein: 180-318
Range on HMM: 16-155/157.0
TPNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKED-KNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIM
  ..|||   .. ....   | .  ..|.|| . | .   .|  . ..|.|.|. . .| . .  | .|.|| .. |.  |.    ||||| ...|.|.|
PgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylm

RYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
 . |.   .|| |.|. .. . || .|. || |.|. |..
yskkitlkkaykylkkCkenvkPnrafveqlseWekqllg
subfamily_MSG5_pd Subfamily MSG5 180-318 4.4e-17 55.7 In-house 31-162 (165) alignment 
Range on Protein: 180-318
Range on HMM: 31-162/165.0
TPNIYLGSQidsldETMLDALDISVVINLSMTCPKSVCIKEDKNFMRIpvNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMR
 ...|| |.      .. . | . .|||..   ..        ..  |  .  .. |.   ..   . .   .  .|| |.||  |.||| .| ..|||.
peklylyse.....pklkellsfdlvinvakeindlellvpavkyyhi..ewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimk

YMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
| ..   |||  .| .   |||.. .. ||.|.| .| |
yynlslrdaydklksvaddispsiglifqlmewevalsk
subfamily_MKPLT_pd Subfamily MKPLT 181-316 3.2e-22 72.8 In-house 27-160 (164) alignment 
Range on Protein: 181-316
Range on HMM: 27-160/164.0
PNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSvcIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRY
 ..|||   .. .|..|..|.|  ..|.|  . .     .  ..... |.|  .|.||...  | .|| .   .| . |.||  | ||| . .. .....
dtlylGnakhatnekvlkdlkithivnvsqekkda..fpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

MKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
 .   ..|| |.||||  ..||  |. || ..|...
kgwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_MKPLV_pd Subfamily MKPLV 181-316 3.2e-22 72.8 In-house 27-160 (164) alignment 
Range on Protein: 181-316
Range on HMM: 27-160/164.0
PNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSvcIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRY
 ..|||   .. .|..|..|.|  ..|.|  . .     .  ..... |.|  .|.||...  | .|| .   .| . |.||  | ||| . .. .....
dtlylGnakhatnekvlkdlkithivnvsqekkda..fpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

MKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
 .   ..|| |.||||  ..||  |. || ..|...
kgwtlkeayeylkerrsivapnrGflkqlakfeeli
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 181-314 7.9e-18 58.3 In-house 8-150 (154) alignment 
Range on Protein: 181-314
Range on HMM: 8-150/154.0
PNIYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIK----ED---KNFMRIPVNDSYQEKLSPYFPMAYEFLEKCR--RAGKKCLIHCLAGISRSPT
 ..|..|.  .|.   |.  .|  ..| ..  .     .    .|    ..... . |  . ..   . .|.||...        | |.|. .|.||| .
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYEN
|.|||.|  .|.    |.  .|. |. |.||  |. ||  .| 
llisylmdklkislslalellkdsryiikPnqGflkqleifek
DSPc Dual specificity phosphatase, catalytic domain 183-314 1.6e-45 149.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 183-314
Range on HMM: 1-132/133.0
IYLGSQIDSLdETMLDALDISVVINLSMTCPKS-VCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYM
.||||. ..  ...|..|.|..|||.....|..    |......||||.|. ..|.|.....|.||.||... |||.|.|| ||||||.||.| |.|...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KMGSDDAYRYVKERRPSISPNFNFMGQLLEYEN
.. ...||..|||||..||||..|..||||||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 183-314 1.6e-45 149.3 In-house 1-132 (133) alignment 
Range on Protein: 183-314
Range on HMM: 1-132/133.0
IYLGSQIDSLdETMLDALDISVVINLSMTCPKS-VCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYM
.||||. ..  ...|..|.|..|||.....|..    |......||||.|. ..|.|.....|.||.||... |||.|.|| ||||||.||.| |.|...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KMGSDDAYRYVKERRPSISPNFNFMGQLLEYEN
.. ...||..|||||..||||..|..||||||.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 183-314 5e-25 81.7 In-house 15-145 (148) alignment 
Range on Protein: 183-314
Range on HMM: 15-145/148.0
IYLGSQIDSLDETMLDALDISVVINLSMTCPKSVCIKeDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMK
..|||.   .|  .| ||... ..| .  ... .  .   ... ....|  .| || .|. . .|..| . .|...|.|.  |.|||  ||. ..... .
LFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

MGSDDAYRYVKERRPSISPNFNFMGQLLEYEN
.   .|. .||..|. . ||  |. || |.|.
vslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 183-316 7.1e-20 64.6 In-house 6-141 (145) alignment 
Range on Protein: 183-316
Range on HMM: 6-141/145.0
IYLGSQIDSLDETMLDALDISVVINLSMTCP--KSVCIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRY
.| || . . | ..|. | || ..|.. .     .    |. . . |  .|     || .|    .|..| .  |   ..||.||.||| |......|.|
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

MKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVL
 .|   .| | |. .|    || .|. .||. |  |
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0038934 (Phosphotyrosine protein) phosphatases II 193-320 3.6e-20 67.9 In-house 48-180 (194) alignment 
Range on Protein: 193-320
Range on HMM: 48-180/194.0
DETMLDALDISVVINLSM---TCPKSVCIKEDKNFMRIPVNDSY----QEKLSPYFPMAYEFLEKcrRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGS
.   |   ..  ||.|.    .  ..   | .  ....|. | .    .| |  .. ...|||..   .|.....|| ||..|..||...|.. ...|  
rylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsa

DDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDH
..|.....|.||.. || ... .||.. . |.|..
eeAialfrekRpgaipnqdyleallkrykelrkav
0040439 (Phosphotyrosine protein) phosphatases II 195-318 1.2e-22 76.1 In-house 72-247 (249) alignment 
Range on Protein: 195-318
Range on HMM: 72-247/249.0
TMLDALDISVVINLSMTCPKSV-----------------------------------------CIKEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRR
 ||  |.|.|...|. ....                                             .|.   . |.. |    ...|.|. . .|.|..| 
rmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrk

------AGKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
       |...|.|| ||..|..|... |.|     .. ..  ..|.......|| . .|.... .|.|..  |..
aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0039614 (Phosphotyrosine protein) phosphatases II 195-319 3.6e-19 64.8 In-house 119-291 (297) alignment 
Range on Protein: 195-319
Range on HMM: 119-291/297.0
TMLDALDISVVINLSMTCPKSV-----------------------CI-----------------KEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRR-
 |.  ....|...|  ......                                          .. . |  ..  |     .. ..  ..|....... 
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--AGKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKD
   |...|.|| ||..|. |... |.|     .. ..  ..|.....|.|| . ...... .| ...  |.| 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0045450 (Phosphotyrosine protein) phosphatases II 196-318 5.1e-23 77.7 In-house 126-305 (307) alignment 
Range on Protein: 196-318
Range on HMM: 126-305/307.0
MLDALDISVVINLSMTCPK--------------------------SVCIKEDKNFMRIPVNDS-----------------YQEKLSPYFPMAYEFLEKCR
||  ....|...|. ....                          |. ....   ....| |.                    ...|.| .. .|.|..|
mlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

R------AGKKCLIHCLAGISRSPTLAISYIMRYMK--------MGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
.       |...|.|| ||..|..|... |.| ..         .  ..|.....|.|| . .|.... .| |..  |..
kaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0040438 (Phosphotyrosine protein) phosphatases II 196-334 1.7e-21 72.3 In-house 105-293 (317) alignment 
Range on Protein: 196-334
Range on HMM: 105-293/317.0
MLDALDISVVINLSMTCPKS-------------------------VCIKEDKNFMRIPVNDS----------------YQEKLSPYFPMAYEFLEKCRRA
|.  ....|...|  .....                         .  ... .  ...| |.                   .. |..    .|||..|.|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDHVLDYNQASRPHRHM
    |...|.|| ||..|. |... |.|     .....  ..|.....|.|| . ...... .| .... ..| .. . .  . .....
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkll
0043336 (Phosphotyrosine protein) phosphatases II 205-317 4.9e-16 54.5 In-house 159-277 (278) alignment 
Range on Protein: 205-317
Range on HMM: 159-277/278.0
VINLSMTCPKSVCIKEDKNFMRIPVND-SYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVKERRPS
|..| .|  ..   ..   .  ... | .  | ||... .  ...|...  ... |.|| ||..|. |... |..     .. ..  ..|.....|.||.
vrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpg

ISPNFNFMGQLLEYENVLI
. ...... .| |..  ..
avqtpsqyrflyealleyl
subfamily_STYX_pd Subfamily STYX 219-318 9.7e-22 70.8 In-house 60-159 (166) alignment 
Range on Protein: 219-318
Range on HMM: 60-159/166.0
KEDKNFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIK
...  .. . | |.  |..  |.|.  ||.... . | | |.|  |||||| .| |.|||  . .   .|..||.|||  |.||  |. || ||| . . 
pdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
subfamily_PTPMT1_pd Subfamily PTPMT1 223-317 3.1e-13 44.5 In-house 75-169 (171) alignment 
Range on Protein: 223-317
Range on HMM: 75-169/171.0
NFMRIPVNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLI
....... |  ..        . ||.|| .  ||.  .|| || .|| ||...|.|   |. ...| ...|..|. |  . . . .| |||. |.
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
0051299 (Phosphotyrosine protein) phosphatases II 228-305 6e-11 37.8 In-house 193-274 (288) alignment 
Range on Protein: 228-305
Range on HMM: 193-274/288.0
PvNDSYQEKLSPYFPMAYEFLEKCRRAGKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVKERRPSISPNFNF
| .... . ..... .  .. ....  |. ...|| ||..|. |... ...     .  ..   .|.....|.|| . .... 
p.dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
0036941 (Phosphotyrosine protein) phosphatases II 235-323 1.2e-17 59.6 In-house 181-283 (297) alignment 
Range on Protein: 235-323
Range on HMM: 181-283/297.0
EKLSPYFPMAYEFLEKCRR------AGKKCLIHCLAGISRSPTLAISYIM--------RYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEYENVLIKDH
 .. ...    .|.|..|.       |.. |.|| ||..|| |... ..|        .. ..   .|.....|.|| . ...... .| |..  |.| .
hgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

VLD
 ..
ltk
0047943 (Phosphotyrosine protein) phosphatases II 239-312 1.6e-12 42.9 In-house 183-267 (273) alignment 
Range on Protein: 239-312
Range on HMM: 183-267/273.0
PYFPMAYEFLEKCRR------AGKKCLIHCLAGISRSPTLAISYIM-----RYMKMGSDDAYRYVKERRPSISPNFNFMGQLLEY
|.. .  ||.|..|.       ... ..|| ||..|. |... ...     .. ..  ..|.......|| . ...... .| |.
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea
0050432 (Phosphotyrosine protein) phosphatases II 239-305 6.6e-10 34.3 In-house 152-287 (308) alignment 
Range on Protein: 239-305
Range on HMM: 152-287/308.0
PY--------------------------------------------------------------FPMAYEFLEKCRRA--GKKCLIHCLAGISRSPTLAI
.|                                                              . .  .|||..|.   |.....|| ||..|. |...
qYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfia

SYIM-----RYMKMGSDDAYRYVKERRPSISPNFNF
 ...     .  ..   .|.....|.||   .... 
ldllleqlekeggvdvfeavkklReqRpgmvqtpeq
0048567 (Phosphotyrosine protein) phosphatases II 239-302 9.7e-10 33.0 In-house 58-124 (157) alignment 
Range on Protein: 239-302
Range on HMM: 58-124/157.0
PYFPMAYEFLEKCRRAGKKCLIHCLAGI---SRSPTLAISYIMRYMKMGSDDAYRYVKERRPSISPN
 .. ....||. .. |||.  .|| ||    .|. ||. .|.. ....  ..|.....  ||.. | 
rFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf
0046845 (Phosphotyrosine protein) phosphatases II 241-306 1.5e-09 33.2 In-house 184-263 (284) alignment 
Range on Protein: 241-306
Range on HMM: 184-263/284.0
FPMAYEFLEKCRRA------GKKCLIHCLAGISRSPTLAISYIMRYM--------KMGSDDAYRYVKERRPSISPNFNFM
.    |||...|..      |.. ..|| ||..|. |... ... ..        ..   .|.....|.||    ..  .
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqy