Gene W01B6.6 in Caenorhabditis elegans

Synonym: CELE_W01B6.6, CELE_W01B6.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP197_AA protein Get Run
CeleP197_AA_75-346 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 67-361 6.3e-118 387.6 In-house 4-301 (302) alignment 
Range on Protein: 67-361
Range on HMM: 4-301/302.0
KKEKEQWSGDETAKKLVASgaFNTSTITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPDVT
..|||.|...|.|||||.|  ..|..... ||.... | ....|..||.|.||....|.||.|..|.||...| ....|.||.|||..|..|..|.|.|.
eeekekWveeeeakklvks..ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvd

VSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMT-AYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVG
.....|.||||.|||.|||.||.|.. |.. ||..|||..||.....||||.||.||..|.... .|..||||.|||||.|..||.|.|||||.......
sedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

ELVTTVEKV----LKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKCSDEEVQKKVVEF
||..|..||     |..||||..|.||.||||..|||.... ..||.||.| |||....| .|.  |....|......|..|..|.|....|..||..|.
eliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkkeev
0050432 (Phosphotyrosine protein) phosphatases II 69-349 2.7e-53 176.7 In-house 22-303 (308) alignment 
Range on Protein: 69-349
Range on HMM: 22-303/308.0
EKEQWSGDETAKKLVAsgAFNTSTITSGFKELSNPKPSAD-MCSIFKNNPKKSRAPDWPIADNKLIKLsHAPGNFICAAKVDVP--EFNRTMIVTQIPDV
.....| .. .|.|    |.... .   |.|| . ||. .  .. ...| .| | .| .. |.  .|| . . ..|.|  ||..   ..|..|.|| |  
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlp

TvsaNIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLLSG-TFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLEN
.   ..||||||......  ||    . | . ..  | .||  | .. ..||..........   .| .|||. . |...|.  |..| .||.  .  ..
n...tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

VGELVTTVEKVLKT--NENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKC
. .|.. .|.| |.  ....| ....|.||.||...| . .  ..| ..|.. |.. |||  | | |.. .|.  ..||.. ..|.| 
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 73-346 4.6e-48 159.5 In-house 5-287 (288) alignment 
Range on Protein: 73-346
Range on HMM: 5-287/288.0
WSGDETAKKLVASGAFNTSTITSGFKELSNPKPSAD-MCSIFKNNPKKSRAPDWPIADNKLIKLSH----APGNFICAAKVDVPEFNRTMIVTQIPDvtv
.| .| .| . .  | .....   |.|| . .|. .  ......| .| | .|..  |.  .|||.     ....|.|  .|.....|..|.|| |    
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl...

SANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLlsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPD----GCSNSLLSTVYHLHNWKQKQGLE
. ..||||||......  ||.   . | . ..  | .||  |.. ..|... .......   .| .|||| .     |...|.  |..| .||   .  .
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

NVGELVTTVEKVLKT----NENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFK
.. .|.. ...| |     .  .| ....|.||.||...|.. .  ..| ..|.. |.. .||  | |.|.. .|.  |..|.. ..|
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
0043336 (Phosphotyrosine protein) phosphatases II 74-345 6.7e-48 158.9 In-house 3-277 (278) alignment 
Range on Protein: 74-345
Range on HMM: 3-277/278.0
SGDETAKKLVASGAFNTSTITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAP----GNFICAAKVDVPEFNRTMIVTQIPdvtVSA
|  . .| |.  .. . ...  .|.|| . |.    ......| .| | .|... |....|||. .     ..|.|  ||.....|..|.|| |    . 
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgP...lpe

NIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPllsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELV
..||||||.... . .||  . . | . |. .| .|   |.. ..|... ...|...   .| .|||| . |...|.  |.|| ..|   .  |..  |.
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

TTVEKVLK----TNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
  ...|..     |. .. ....|.||.||...|.. .  ..| ..|.. |.. .||  | | |.. .|.  ...|.. ..
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 84-345 6.1e-19 63.3 In-house 15-283 (305) alignment 
Range on Protein: 84-345
Range on HMM: 15-283/305.0
ASGAFNTSTITSGFKELSNPKPSADMCSIfKNNPKKSRAPDWPIADNKLIKLSHAP----GNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIF
 . . .....   .|.| . . | |. .  ..| .|.|  .  . |.. |.|.. .     ..| |. ||  . . . ||.| |   .   ..||||.|.
earvysdkgleaqykslyeeeesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgP...lkntvadfWrliv

QEEIVSIVIAV-MPLECSVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLP-DGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKT
.| ...||. . .  .     .| .|   .   ..|.. .. |   .|   .   |..   |. ..|   . |.| .| ..   .  . |.. ...| |.
eekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkd

NENT-----VLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
 ..      .    .|.||.|. ...   .  ..| ..|.  |.| .|| .| ..|.. ||.. .| |...  
qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
0039614 (Phosphotyrosine protein) phosphatases II 85-348 1.4e-47 158.0 In-house 26-292 (297) alignment 
Range on Protein: 85-348
Range on HMM: 26-292/297.0
SGAFNTSTITSGFKELSNPKPSaDMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPG-----NFICAAKVDVPEF-NRTMIVTQIPdvtVSANIEDFWRMI
  |......   |.|| . ||.   .. ...| .| | .|... |.  .||.. .|     ..|.|  ||.... .|..|.|| |    . ..||||||.
ekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP...lpetvedFwrmv

FQEEIVSIVIAVMPLECSVTLQQLFPLLSGtfsNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSnsLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK--
... . .||    . |.... .| .|  .|   ..|... ...||.    .| .|||| ..|.|  .  |... ..|   .  ...  |   .|.| .  
weqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvreal

----TNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNK
     .. .. ....|.||.||...... .  ..| ..|...|.. .||  |.| |.. .|.  ...|.. ..|.|
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0047943 (Phosphotyrosine protein) phosphatases II 86-345 1.4e-50 167.6 In-house 7-272 (273) alignment 
Range on Protein: 86-345
Range on HMM: 7-272/273.0
GAFNTSTITSGFKELSNPKPSAD-MCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPDVTvsaNIEDFWRMIFQEEIV
........   |..| . ||. .  ......| .| | .|... |.  .||.. . ..|.|  ||.....|..|.|| |      ..||||||.... . 
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvr

SIVIAVMPLEC-SVTLQQLFPLLSGT-FSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK------
 ||  . . |   ..  | .||  |. . ..||.. .......   .| .|||. . |...|.  |..| ..|   .  ... .|.. .|.| |      
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

TNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
 |. .| ....|.||.||...|.. .  ..| ..|...|.. .||  | | |.. .|.  ...|.. ..
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 87-344 1.8e-21 71.5 In-house 17-278 (288) alignment 
Range on Protein: 87-344
Range on HMM: 17-278/288.0
AFNTSTITSGFKELSN-PKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSH----APGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQE
| | . ... .. |..  | ...  .   .| || | ..    | | .|| .    |  ..| |. .|. . ... | || |   . . ..|||......
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgP...ladtvndfWelvyen

EIVSIVIAVMPLECSV-TLQQLFPlLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLpdGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNEN
..  ||     .|    . .. .|  ...  |.|.. .  ...     ..  .|..      . |  | |.   | ...  |.  .|.  ...|  .|..
ktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

T----VLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALW
     .   ..|.||.|| ..| . .  |.... ..  ... ||| .|  ||..  |.  ......  
dtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 88-343 5e-18 60.4 In-house 24-288 (298) alignment 
Range on Protein: 88-343
Range on HMM: 24-288/298.0
FNTSTITSGFKELSNPKP----SADMCSIFKNNPKKSRAPDWPIADNKLIKLSH----APGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIF
.. .. .. |..|.. .          .  ..| || | .|    |   . |..      ...| |. ..  . . . |.|| |   . . .||||||. 
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP...ltetvedFWrmvt

QEEIVSIVIAVMPLEC-SVTLQQLFPLLSGtfSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKV---L
.|.| .||.     |   .. .. .|       ..|.. .. .. ..   ..  .|.|     ...      |  .| .|.  ||   ... ..||    
eedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasq

KTNE--NTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMAL
. .     ..   .|.||.||   . . .  |.|.. |   .... || .| |.|.  .|.  .. |.  
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_PTPN3_pd Subfamily PTPN3 88-341 8.9e-18 59.2 In-house 12-271 (280) alignment 
Range on Protein: 88-341
Range on HMM: 12-271/280.0
FNTSTITSGFKELSNPKPSADMCS-IFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDV--PEFN--RTMIVTQIPdvtVSANIEDFWRMIFQEE
... ..   |..|   ||. ..      .| .| |  |    |.  .||.... ..| |  |..  |  .     |.|| |   ..   .|||.|.....
lesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGP...laktatdfWqmvweqk

IVSIVIAVMPLEC-SVTLQQLFPLLSGTfSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKT----
.  ||.    .|   |   | .|  . . ...|.. .. .| |.  ..    | .     ...   .     .| ...  ..  .... ||.| |.    
sslivmlttlverGrvkChqyWPetede.leygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk

NENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
.| .|.    ||||.| ...| |..  ......|.| .|. ..|  |. ||..|.|.. |  |.
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_PTPN14_pd Subfamily PTPN14 88-347 1.2e-10 35.9 In-house 20-298 (300) alignment 
Range on Protein: 88-347
Range on HMM: 20-298/300.0
FNTSTITSGFKELSNPKPSADM-CSIFKNNPKKSRAPDW-PIADNK--LIKLSHAPGNFICAAKVD--VPEFNRTMIVTQIPDvtvSANIEDFWRMIFQE
.. . .   . .... .  |.. ..  ..| .|.| .|  |  ||.  |.   ..  ..| |...   |   .|. ||.| |       ..|||.|....
leegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeq

EIVSIVIAVMPL-ECSVTLQQLFPLL--SGTFSNHGKMFLNNKKVDSAVAMT--AYTLEVLPDGCSNsllsTVYHL--HNWKQKQGLENVGELVTTVEKV
..  ||.      .      . || |  .    ..||  . .| .... ...  ...|. || .       ||.||   .| ...  |.| . .  .|.|
gvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer....tvwhlqytDWpdhgvPeDvkgflsyLeev

----LKTNEN---------TVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
     |||..          ..   .|.||.| ...    . .... .|.. |..| .||  |  ||..  |.. |....  ..||
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0040438 (Phosphotyrosine protein) phosphatases II 89-361 1e-54 181.3 In-house 16-292 (317) alignment 
Range on Protein: 89-361
Range on HMM: 16-292/317.0
NTSTITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIV
.   . ..|..| . |..   ......|..| | ||... |.  .|||. .|    ..|.|  ||.|...|..|.|| |    .  .||||||.... . 
dftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...pntvedFwrmvweqgvt

SIVIAVMPLECS-VTLQQLFPLlsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKT----NE
.||  . . |.. .. .| .||  |.. ..|... ......    .| .|||| ..|.|.|.  |..| ..|      ..  .|.  .|.| .     ..
vivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpgg

NTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKCSDEEVQKKVVEF
 .. ....|.||.||...... .  ..| ..|...|.. .||  |.| |.. .|.  ...|.. ..|.|. .|.........
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 89-355 1.1e-17 59.2 In-house 21-293 (319) alignment 
Range on Protein: 89-355
Range on HMM: 21-293/319.0
NTSTITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIV
 . ..   ||.|.....     .  ..| || | ..    |.  ..||. .|    ..| |. .|  . ..  | || |   ..  |||||||...||. 
getllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaP...lentiedfWrmvWeeess

SIVIAVMPLE-CSVTLQQLFPllSGTFSNHGKMFL--NNKKVDSAVAMTAYTLEVLPDGCSNSLLsTVYHLHNWKQKQGLENVGELVTTVEKVLKTNEN-
 .|.     |   | |....|  . .| . |.. .  ....  . . .   .|. . .      . . ..  .| ...  |.   |.  .... |. |. 
ivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevetRev.khfqyteWpdhdvPekatslldllkrirksrekt

----TVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKCSDEEVQ
     |    .|.|| || ..|.  .  |..   ..  ..  .||  |  .|.. .|.. .. |.  . .   .. |||
qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 90-341 6.5e-18 59.6 In-house 18-273 (315) alignment 
Range on Protein: 90-341
Range on HMM: 18-273/315.0
TSTITSGFKELSNPKPSADMCSIFKNNPKKSRAPD-WPIADNKlIKL---SHAP-GNFICAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIV
|. ..  |..| .|...    .  ..| || |  .  |.  .. .||      |  ..| |...   . ... | .| |     | ..|||||..||.. 
talfseefhdlpdPdiyrqrvaretinfkknryknilPldsar.vkleviddsPdsdyinasyiksvdddkayiasqgPl...kasvddfwrmvlqekvt

SIVIAVMPLECS-VTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTAYTLeVLPDGcSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKT---NEN
.||.     |   .  .| .|   .   . |.. ..  ....   ..|  | |. ..  .|   | .....| .|   .... |.  . .|      .| 
tivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkef

TVL-MSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
..|   . |.||.| ....   .  ..... |.  ... .|| .|  ||   ...  .. |.
sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 90-256 2.4e-07 24.8 In-house 14-185 (301) alignment 
Range on Protein: 90-256
Range on HMM: 14-185/301.0
TSTITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHA------PGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEI
. .. . .|||.. ..   . .. ..| . .|  .  . |.. | |..         ..| |  .|    ..  |..| |   .   . ||||.|.||  
snkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgp...mkktlvdfWrliwqekp

VSIVIAVMPLECS-VTLQQLFPLLSGTFSNHGKMF--LNNKKVDSAVAMTAYTLeVLPDGCSNSLLSTVYHLHNWK
||||.     |..    .| .|  . . .. |..   |.|..|     .   .. .. || .|. .   .. .. |
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnv.kiqdgsnngyierkfkvksdk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 91-347 2.2e-14 48.2 In-house 16-279 (307) alignment 
Range on Protein: 91-347
Range on HMM: 16-279/307.0
STITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNK--LIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVI
....  |..|.. .| .     |. |..| |  | .  |.   ..|.. .  ..| |  . .    . .|..| |     . . .|| |. ||.. |...
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgp...lentqysfwamaiqekvesvim

AVMPLEC-SVTLQQLFPLLSG---TFSNHGKM-FLNNKKVDS----AVAMTAYTLEVLPDGCSNSLlsTVYHLHNWKQKqGLENVGE-LVTTVEkVLKTN
 .  .|   .  .| .||  |   .|.....   ..|  ..        .   ||.|   . | ..  . .  .|| .. |  ..    .  .|   . .
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrti..qhlqwenwpdr.gvpqinltainlle.avryd

ENTVLM-SMNGIGRAGTMLTLFTSMLSVQKS-KEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
.| |..    |.||.||....   .  . .     . |... .|| .|   ...  |.  .|| .  .| .
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 91-341 2.7e-11 37.5 In-house 20-232 (392) alignment 
Range on Protein: 91-341
Range on HMM: 20-232/392.0
STITSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKL----SHAPGNFICAAKVDVPEFNRTMIVTQIPDVtvsANIEDFWRMIFQEEIVSI
. ... |..| .|. . . ..  . | || |  .    |.  .||      .  ... |. ..  . ....| .| | .   | ..|||||.|||.. .|
alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpna...aslddfwrmvfqenvtti

VIAVMPLECSvtlqqlfpllsgtfsnhgkmflnnkkvdsavamtaytlevlpdGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK-TNENT---V
..     |                                                .    . .|. .| .|.  . .  |.  ...|     . |   .
amvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpli

LMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
.    |.||.| .... . .   .|.. |.  ... ..| .|  .|.  .|.  .. |.
ihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygav
0036941 (Phosphotyrosine protein) phosphatases II 92-360 4.7e-55 182.3 In-house 14-292 (297) alignment 
Range on Protein: 92-360
Range on HMM: 14-292/297.0
TITSGFKELSNPKPSAD-MCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPDVTvsaNIEDFWRMIFQEEIVSIVIAV
 . . |.|| . ... .  ......| .| | .|... |.  .||.. . ..|.|  ||.....|..|.|| |  .   ..||||||.... . .||  .
lllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmlt

MPLE-CSVTLQQLFPLLSGTFSNHGKMFLNNKKVDS--AVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK------TNENT
 . |   .. .| .||  | . ..|........|..     .| .||||.. |...|.  |..| ..|      |.. .|.  .|.|.|       .. .
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

VLMSMNGIGRAGTMLTLFTSMLSVQ---KSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKCSDEEVQKKVVE
. ....|.||.||...... .  ..   | ..|...|.. |||  | | |.. .|.  ...|.. ..|.|  .|...|.|..
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 93-341 1.1e-17 58.9 In-house 11-262 (283) alignment 
Range on Protein: 93-341
Range on HMM: 11-262/283.0
ITSGFKELSNPKPSADmCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVP---EFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIA
    .|.|| |. .|| ..  ..|..| |  .   ||.. ..|   . ..| |. . |    . ..  |..| |   .   . |||.|.|.|.|..||. 
frevlkrlsvpdldad.iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsP...ldrtvvdfWkmvfdekitaivml

VMPL-ECSVTLQQLFPLlSGTfSNHGKMFLNNKKVDSAVAMTAYTLEVLPD-GCSNSLLSTVYHLHNWKQKQGLENVGELV--TTVEKVL-KTNE-NTVL
     .  .   | .|   |.  ..|.. .  .|  .  ...   | .  .  . ..|| . | . .| . .    .  ||    |     . ..   |.
tklqedlrikCsqyWPk.rGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

MSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
   .||||....... .|.  .. .  |.  ...  .| .| ..| . ||.  || ..
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN13_pd Subfamily PTPN13 94-341 1.7e-15 52.0 In-house 14-265 (273) alignment 
Range on Protein: 94-341
Range on HMM: 14-265/273.0
TSGFKELSNPKPSaDMCSIFKN--NPKKSRAPDWPIADNKLIKLSHAPGnFICAAKVD--VPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIA
.  |||| . ||  | |.. |.  | .| |  .    |.  .||.   | .| |. .   | . . ..|..| |   .   ..|||.|... .   |.. 
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGP...lPetvkdfwqmvweqkaeviamv

VMPLEC-SVTLQQLFPLLSG-TFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNE---NTVLM
 .  |   |  .. .|   . .   .... ... ||    ...  .|.|     ..|   .  .. .|   .   .  ||.. | .| . ..     |  
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvh

SMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
   ||||.||..|. . .  ... ||.. |||. |||  | |.|   ||.  |..|.
csaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 94-342 1.9e-13 44.7 In-house 25-276 (303) alignment 
Range on Protein: 94-342
Range on HMM: 25-276/303.0
TSGFKELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHApgNFICAAKVDVPEfNRTMIVTQIPDVTVSAnieDFWRMIFQEEIVSIVIAVMPL
.  |.....  |       | .| .| |  |    |   .||| .   .| |. ...   ..  |.||.|    .|   |||.|| .. .  ... .   
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsds..syihasylelds.skkailtqlplshtaa...dfwqmiieqkvkcvlllltds

EC-SVTLQQLFPLlSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLP--DGCSNSLLsTVYHLHNWKQKQGLEN----VGELVTTVEKVLK---TNENTVL
|  ..  . .||     | .  . ..   .      .  ..| ||   .|  .|.|  |.| ..| ...   .    .   .  .. ||.    .. || 
eydklggdsvfpr.nqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksfl.hvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvy

MSMNGIGRAGTMLTLFTSMLSVQKSK-EVNPKEILIKLRGERSGLVENADQFNTVHRAMA
||. | |||||.  . |. ||... .  ..    | ..|  |   |.|  ||  |.  .|
mslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 95-345 5.5e-18 60.1 In-house 24-280 (318) alignment 
Range on Protein: 95-345
Range on HMM: 24-280/318.0
SGFKEL-SNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVI-
. ...|  ... .. . |. . | .| |  .    |.  .||..  |    ..| |  .|  . ... | .| |   ..  |||||||... .   ||. 
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaP...lpetieDfWrmvWeqnsavivml

AVMPLECSVTLQQLFPllSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTN-----ENTVL
. .  .. . ... .|  |    ..||.  . |.  .   ..  ...|  .....|     ||  .| ..  .|....|.  | .| |..     . .| 
tqeeergkakvhryWP..skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

MSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
    |.||.|. ... . .  ... . |.  ..  .|| .|  .|   ||.. .. ..    
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_PTPN23_pd Subfamily PTPN23 97-340 9e-16 52.5 In-house 21-275 (288) alignment 
Range on Protein: 97-340
Range on HMM: 21-275/288.0
FKELSNPK---PSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKV-DVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMP
|||| . .        ..| | ...| |  |    |.. .||     ..| |. | |.     ..|.|| |       . |||.|....    ||. . .
fkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPl...qstlnDFWlmvyeqkssviVmllsk

LECSVT-LQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQ---KQGLENVGELVTTVEKVLKTNEN-----TVL
 |   .  .. .|   |   ..|.. .  |.| ..  .  ..|..   . ..    .  .|..| .    .  |.. ...  ||. ......      |.
eelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvv

MSMNGIGRAGTMLTLFTSMLSVQKSKEV-NPKEILIKLRGERSGLVENADQFNTVHRA
    |.||.|..  ... .  ..| . . .  ... .|| .|   |.. .|.. .  |
hCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_PTPN9_pd Subfamily PTPN9 97-341 9.1e-12 39.6 In-house 22-286 (297) alignment 
Range on Protein: 97-341
Range on HMM: 22-286/297.0
FKELSNPKPSAD-MCSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVM
..|. | ...   ..|  . | .| |  |    |.  ..|.. ..    ..| |  ||  . ....| || |   .   ..|||||....|.. ||..  
yaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGp...lkktvsdfWrmvWeqevlvivmttr

PLEC-SVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVA------------------MTAYTLEVLPD-GCSNSLLSTVYHLHNWKQKQGLenVGELVTTV
 .|   .  .| .|| ... ...|.. ..| .|..  .                  .| . .   || |  .|  | .  |.. ..||.|  . . ..  
vvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal..avkelgde

EKVLKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
.|   ..   |.    ||||.||. ||  ..  ...   |.  | . .||  |.  .   .|..  . |.
wkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 99-191 7e-08 26.4 In-house 35-127 (310) alignment 
Range on Protein: 99-191
Range on HMM: 35-127/310.0
ELSNPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSH---APGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVM
 |   . |.     .|.. .| |  |    |.  .||       ...| |  |    .  |.|..| |   .   | |||||||||   ||.. . 
kldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgp...lqhtiidfwrmifqeraesilllck
DSPc_SM00195 100-345 1.1e-48 161.2 In-house 9-262 (263) alignment 
Range on Protein: 100-345
Range on HMM: 9-262/263.0
LSNP-KPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAP----GNFICAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMPLE
| .  .|.   ....|.| .| |  . .. |.. .||.. .     ..|.|  ..... ....|.|| |    .  .||||||...|..  ||. ... |
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeee

-CSVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAV-AMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGL---ENVGELVTTVEKVLKT-NENTVLMSMNG
 .. . .. .|  ||. ...||. .....|..    .. .|||.  .|....   |.|. .||....     ..| ||. .|.|  .| .. .| .. .|
ngkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

IGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
.||.||..|. . . .... |.|. .||. .|| .| |.|.. .|. ....|.. ..
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 100-345 1.1e-48 161.2 In-house 9-262 (263) alignment 
Range on Protein: 100-345
Range on HMM: 9-262/263.0
LSNP-KPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAP----GNFICAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMPLE
| .  .|.   ....|.| .| |  . .. |.. .||.. .     ..|.|  ..... ....|.|| |    .  .||||||...|..  ||. ... |
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeee

-CSVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAV-AMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGL---ENVGELVTTVEKVLKT-NENTVLMSMNG
 .. . .. .|  ||. ...||. .....|..    .. .|||.  .|....   |.|. .||....     ..| ||. .|.|  .| .. .| .. .|
ngkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

IGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
.||.||..|. . . .... |.|. .||. .|| .| |.|.. .|. ....|.. ..
vgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 100-321 4.3e-14 46.8 In-house 17-244 (281) alignment 
Range on Protein: 100-321
Range on HMM: 17-244/281.0
LSN--PKPSADMCSIFKN--NPKKSRAPDWPIADNKLIKLSH-----APGNFICAAKVDVPEFNRTMIVTQIPDVTVSAnieDFWRMIFQEEIVSIVIAV
.||    | .|.|..|..  | || |  . |  |   ..|          ..| |  .  | ..|  |.|| |     |   ||||||.||.  .||. .
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketra...dfwrmiwqenttaivmlc

MPLECSV-TLQQLFPLLSGTFSNHGKMFLNNKkvDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNENTVLMSMNGI
  ||       . ||  .    .  |. .. .  ||.|  .  |  .      .. | | .  ..| . |  |    ..  . |.       |.    |.
qfletnrekcaeyfprnahcclqfdklsvsye..dstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagv

GRAGTMLTLFTSMLSVQKSKEV-NPKEILIKLR
||.||....  .. |..    . . |.|. .||
grsgtlmaveialqsihshftlpdikqivshlr
0045098 (Phosphotyrosine protein) phosphatases II 102-347 1e-25 86.2 In-house 19-274 (278) alignment 
Range on Protein: 102-347
Range on HMM: 19-274/278.0
NPKPSADMCSIFKNNPKKSRAPDWPIADNKLIKlshapgNFICAAKVDVPefNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQ
 . ||   .... .| .| | .|..  |.  .|      ..| |  .|..  ....|.|| |      ...|||||.... | .|| .   .|   .   
lgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekca

QLFPllSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPD----GCSNSLLSTVYHLHNWKQKQGLENV-----GELVTTVEKVLK--------------T
| .|  .| . ..|..........    .|  ||.|           |.  |..|...|      ..       ||.  ....||               
qywp..eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

NENTVLMSMNGIGRAGTMLTLFTSMLSVqkSKEVNPKEILIKLRGERSG-LVENADQFNTVHRAMALWFKN
.. ..   . |.||.||.  ... .  .   . |.. |.. .||  | |  |.| .|.. ...........
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 103-342 9.6e-19 62.5 In-house 30-268 (288) alignment 
Range on Protein: 103-342
Range on HMM: 30-268/288.0
PKPSADMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVT-LQQ
 . | |. . | .|| . |  . |  |   .|||  |  .| |  |   ...| .| .| |   . . || .|.|......  ||.    ||      ..
neasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaP...lngtieelWkmllesdveyivmlcellekGkeksae

LFPLLSGTFSNHGKMFLNNKKV----DSAVAMTayTLEVLPDGcSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLT
 ||.  |     |..    ||     |  | ..  .| .   |  .. .  . ||..|...   ||    .  .| . ....  |..| .|.||.||.  
yfPsklGekarigrlctvvkkkradidklvkvs..llriskeg.eekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlil

LFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMA
 .  . |.. .  .  ...| ||| ||   ..   |.  ||| . 
ilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 106-344 2.2e-15 51.4 In-house 23-258 (267) alignment 
Range on Protein: 106-344
Range on HMM: 23-258/267.0
SADMCSIFKNNPKKSRAPDW-PIADNKlIKLSHAPGNFICAAKVDVPEFNRTMIVTQipdVTVSANIEDFWRMIFQEEIVSIVIaVMPLeCSVTLQQLFP
|   .|| ..| .. |  |  |  |.. . |.    ..| |. |.  . ....||||    ...  | ||. .| ....  ||. ...      .....|
stisqsiaeknqernrlddnlpyddtr.vilrtkeeeyinasyvegyktknafivtq...dplkntitdfltvihdqkvpvivl.ltkv.ftdnirlfwP

LLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSlLSTVYHLHNWKQKQGL-ENVGELVTTV--EKVLKTNENTVLMSMNGIGRAGTMLTLFTS
   |   ..  . ..             |||.     |     |.|. ..|. .      .  |.  .  ... . |   |.   .|.||.||.|.. . 
Pkmgqakkyqdltvehslekeendyqiitlelkfknesah.nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsq

MLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALW
.  ...   ..  . | |.|  | |||.  ...  .|. .| .
leraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 107-334 4.8e-14 46.7 In-house 44-272 (290) alignment 
Range on Protein: 107-334
Range on HMM: 44-272/290.0
ADM-CSIFKNNP--KKSRAPDWPIADNKLIKLS-HAPGNFICAAKVDvpEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLE-CSVTLQQ
  .  .|| .|.  || |  | .  |   . |.   .|... |  |.    . ..|.|| .   . . . |.|||. ||..  ||.    .|      .|
qylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk..GlkamfiltqGa...lkdtvidiwrmvlqekvaaivmlceliedGkakceq

LFPLLSGTFSNHGKMFLNNKKV-DSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFT
 .|  .|     |.. .   .  |    .   || |       .     ...  | .|        |. |.  . |..   |.    ||||.||. .. .
yypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaiev

SMLSVQKSKEVNPKEILIKLRGERSGLVENADQF
..  . . ||... ..   ||  | . |.   |.
glqilldGkeldlldlvralrnsrlnsvqvdiqy
0046845 (Phosphotyrosine protein) phosphatases II 108-349 1.4e-43 144.7 In-house 20-278 (284) alignment 
Range on Protein: 108-349
Range on HMM: 20-278/284.0
DMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPG-----NFICAAKVDVP-----EFNRTMIVTQIPDVTvsaNIEDFWRMIFQEEIVSIVIAVMPLECSV
  ......| .| | .| .. |.  .||.. .|     ..| |  ||..      .....|.|| |  .   ..||||||......  ||    . | ..
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelvengr

-TLQQLFPLLsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDG-CSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKT------NENTVLMSMNGI
    | .||  |.. ..|... ......    .| .|||. . | ...|.  |..| ..|   .  ...  |.. ...| .       .. .| ....|.
ekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRAGTMLTLFTSMLSVQKSK---EVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKC
||.||...| . .  ..| .   .|.. |.. .||  | | |.. .|.  |..|.. ..|.| 
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 108-347 5.4e-43 143.3 In-house 47-306 (307) alignment 
Range on Protein: 108-347
Range on HMM: 47-306/307.0
DMCSIFKNNPKKSRAPDWPIADNKLIKLSH-----APGNFICAAKV--------DVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMPLE
  .. ...| .| | .| .. |.  .|||.      ....| |  |        |.. ..|..|.|| |    . ..||||||.... .  ||    . |
ysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl...petvedFwrmlweqgvtvivmltelve

CSV-TLQQLFPLLsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPD-GCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK------TNENTVLMSM
.      | .|.  |.. ..|... ......    .| .|||| .  |...|.  |..| ..|   .  ... ||.  .|.|.|       .. .. ...
lgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCs

NGIGRAGTMLTLFTSMLSVQKSKE---VNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
 |.||.||...... .  ..| ..   |.. |.. .||  |.| |.| .|.  ...|.. ....
aGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 108-341 4.6e-16 53.5 In-house 38-279 (290) alignment 
Range on Protein: 108-341
Range on HMM: 38-279/290.0
DMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGN------FICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLE-CSVTLQ
 .  . ..| .. |  .  . |.. | | . .|.      .| |. ..  . ..  |.|| |   ||  . |||..| ||..  ||. .   |  .|. |
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgp...vsntlvdFWkliwqekvtiivmltniieegkvkCq

QLFPLLSGTFSNHGKMFLNNKKVDSavAMTAYTLEVLPDGC-SNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKT-----NENTVLMSMNGIGRAGT
| .|  . .  .. .. |.| .. .   ..  .|||  .    ..   | |.. ||...  ..|    ....|.. ||     |.  |.   ...||...
qYWpdsdtkaygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsav

MLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
 ... |..  ...   ..  ..| ..|  . |.|. ..|...... .
fcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 108-342 1.1e-13 45.8 In-house 39-275 (287) alignment 
Range on Protein: 108-342
Range on HMM: 39-275/287.0
DMCSIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSV-TLQQLFPLL
   .| ..| .| |  .  . ||. . |     ..| |. .|  . ..  |... |   ..  . .||..| ....  ||. .   |       | .|  
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesP...mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpee

SGTFSNHGKMFLNNKKvdSAVAMTAYTLEVLPDGC-SNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNEN-----TVLMSMNGIGRAGTMLTLFT
. .   . .. | |..      ..  .|||  ..  .. .  . |.. ||...  ...    .  .|.  ||.        |    ...||.....   |
ksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat

SMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMA
..  ...   ..  ..| . |  . | |  ..|.. .  .. 
tinkckteGviDvfqvlksqriqkpgsvqtveqykfindivl
0040439 (Phosphotyrosine protein) phosphatases II 110-347 1.8e-44 147.6 In-house 5-248 (249) alignment 
Range on Protein: 110-347
Range on HMM: 5-248/249.0
CSIFKNNPKKSRAPDWPIADNKLIKLSH----APGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFP
......|..| | ||... |.  .|||.     ....|.|  .|.. ..|..|.|| |    .  .||||||.... | .|| .  . |.  .. .| .|
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP...lpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

LlsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK------TNENTVLMSMNGIGRAGTMLTL
|  |.. ..|... ....|..   .| .|||. . ....|.  .... ..|   .  ... .|.  .|.|.|      ... .. ....|.||.||....
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

FTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
.. .  ..| ..|...|.. .||  |.| |.| .|.  ...|.. ....
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 110-346 2.3e-39 130.7 In-house 3-244 (245) alignment 
Range on Protein: 110-346
Range on HMM: 3-244/245.0
CSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPDVTvsaNIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFP
......|..| | .| .. |. ..|||. .|    ..| |  ||........|.|| |      ..||||||.... | .||    . | . |. .| .|
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqywp

LlsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK-----TNENTVLMSMNGIGRAGTMLTLF
|  |.. ..|... .......   .| .|||| ..|.. |.  ..|| ..|   .  ...  |.  .| |.|      |. .. ... |.||.||.....
l..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

TSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFK
. .  ..| ..|.. |.. .||  |.| |.. .|.  ...|.. ..|
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 110-345 1.9e-31 104.9 In-house 4-242 (243) alignment 
Range on Protein: 110-345
Range on HMM: 4-242/243.0
CSIFKNNPKKSRAPDWPIADNKLIKLSHapGNFICAAKVDVPEfnrTMIVTQIPDVTvsaNIED----FWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFP
......| .| | .| .  |.  .||.   ...|.|  ..|..   ..|.|| |      ..||    ||||.... | .||    . |   .   |..|
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvtp...rliatqgPlpe...tveddlasfwrmlwelgitvivmltelvElgrekcaqywp

llsGTFsNHGKMFLNNKKVDSAVAMTAYTLEVLPDG-CSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVL------------KTNENTVLMSMNGIGR
   |.. ..|... ..... .   .| .||.. . .    ..| . || ..|   .  ...  |.  ...|             .... .... . |.||
...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

AGTMLTLFTSMLSVqkskEVNPKEILIKLRGERSG-LVENADQFNTVHRAMALWF
.||...... .| .    .|.. |.. .||  |.|  |.. .|.  ...|.. ..
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 110-355 4.2e-16 54.0 In-house 42-296 (307) alignment 
Range on Protein: 110-355
Range on HMM: 42-296/307.0
CSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVT-LQQLFP
 |  |.|  | | .|    |.. .||.. .|    ..| |  .   . ... |. | |   | | |.|||||| . |.  ||.     | .    .. .|
vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdP...veatigDfWRmiaeqevtlivmlsnlteknrkkcakYWp

LLsgTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDG-CS----NSLLSTVYHLHNWKQKQGLENVGELVTTVEKV---LKTNENTV-LMSMNGIGRAGTM
    .  ..|..  .  . ...   .  .|.|   . .|    .|   . ||  .||  .  |    |.  .|.|    |.|.  . .   .| ||.|..
ie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif

LTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKCSDEEVQ
..|   .  ... ..|.  |.  .|| .|. ||.. .|.  ..||.. . .   .||.|.
valdsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvd
subfamily_PTPRD_pd Subfamily PTPRD 110-355 5.9e-16 53.2 In-house 42-289 (564) alignment 
Range on Protein: 110-355
Range on HMM: 42-289/564.0
CSIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFP
 .  . | .| |  .    |.  ..||. .|    ..| |  .|  . ... | || |   ..  |||||||...... .||.     | . | ... .|
aankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgP...laetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP

LLsGtFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNEN----TVLMSMNGIGRAGTMLTLFT
   |   ..|..  . ..      ..  |...     |.|   . .|  .| ..   |.  .|.. ..|| ..||.    .|    .|.|| || ...  
ek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfivida

SMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKnkCSDEEVQ
 .  ....| |.  .....|| .|  .|.. .|.  .|.|..   .  | ..||.
mlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala..cgnteve
subfamily_PTPRK_pd Subfamily PTPRK 111-341 4.8e-18 60.0 In-house 38-273 (314) alignment 
Range on Protein: 111-341
Range on HMM: 38-273/314.0
SIFKNNPKKSRAPDWPIADNKLIKLSHAPGN----FICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPL
.  ..| .|.|  |    |. ...|    |.    .| || .|  .  .  |||| |   .   ..||||....|.  |||.     | . |   . .| 
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgP...lqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

LSGTFSNHGKMFLnNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNE----NTVLMSMNGIGRAGTMLTLFTS
 . .. .   ... . .... . .  ...| |  | ..  .   ..  .| . .   .   |.. | .| |..|    ..|.  ..| ||.|| ... . 
dtevygdikvelv.etellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

MLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
.  ... . |.  ..  .|| ... .||  .|.. .. ..
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPRG_pd Subfamily PTPRG 111-348 4.8e-13 43.2 In-house 42-290 (563) alignment 
Range on Protein: 111-348
Range on HMM: 42-290/563.0
SIFKNNPKKSRAPDWPIADNKLIKLSHAPG-----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIvSIVIAVMPLE--CSVTLQQLF
|  ..| .| |  .    |.  .|||  ||     ..| |  .|  . ..  |.|| |   .   ..||||||....  .|.. .  |.       .. .
sqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgp...lkdtfddFWrmiWeqnv.aiivmitnlvergrrkcdvYW

PLlsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLP------DGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNEN----TVLMSMNGIGRAG
|    .  . |.. .. .. .  .  |  || .        . | . .| . ||  .| ...  |     .. |.|  ..|..    .|    .|.||.|
Pk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtG

TMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNK
| . | | .  .|. . ||  ..| ..| .|  ||.. .|.  .| |.  . . |
tyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_egg_pd Subfamily egg 111-348 1e-12 42.4 In-house 35-273 (307) alignment 
Range on Protein: 111-348
Range on HMM: 35-273/307.0
SIFKNNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECsVTLQQLFPLL
.. .|| .|.|..  . .|   .||    |    .|| | .|.   .  ..|..| |   .    .|||||.||||.  ||.     |     .  .|  
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqap...lkntvddfwrmvfqeevqyivmltsrkes.erceyywpka

SGTFSNH--GKMFLNNKKVDSAVA--MTAYTLEV-LPDgcsnsllSTVYHLHNWKQ-KQGLENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFT
         | . ..| ||||.    ..   | .  .|           .|  |.   . . .|   .  . |. .  . .|. ...|. .|.|.... .
esdslvtvpGslrienlkvdskadplfrvtklklvGgd.......deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaiei

SMLSVQKSkEVNP---KEILIKLRGERSGLVENADQFNTVHRAMALWFKNK
..||. .   .     ..    || .|   || . ..  |.| ....|.. 
allsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv
0049772 (Phosphotyrosine protein) phosphatases II 111-350 4.5e-11 38.5 In-house 41-285 (314) alignment 
Range on Protein: 111-350
Range on HMM: 41-285/314.0
SIFKNNPKKSRAPDWPIADnKLIK---LSHAPGNFICAAKVDVPefnRTMIVTQIPdvtVSANIEDF----------WRMIFQEeIVSIVIAVM------
. .  |..| | .|.. ||  . .   |..   ..| |  || .   .. |.|| |    . ...||          |||....    . . ||      
adlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgp...leitvvdfreepvlyyngwrmvlrg.dlnvrdivmsrdevl

-----------------------PLECSVTLQQLFpllsgtfsnhgkmflnnkkvdsavamtaytlEVLPDGCSNSLLSTVYHLHNWKQkQGLENVGELV
                       .. .  .|..|                                |.| |.   . |   |. ...    .      . 
adelsrLdaAlgKtpllildgngneptaadlellk...............................eelydpelferlgikylripvpD.gsaplledfd

TTVEKVLK--TNENTVLMSMNGIGRAGT-MLTLFtsmlsVQKSKEVNPKEILIKLRGERS-----GLVENADQFNTVHRAMALWFKNKCS
  .| ...  ......   . |.||.|| ... .     . |   |...|.|  .|  |.     |..|. .|.  ...|.  ..|.. .
eflefieeadkggpvlvHCkaGkgRtgtfvvaay.....lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkflkk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 111-340 2.9e-09 31.3 In-house 30-265 (285) alignment 
Range on Protein: 111-340
Range on HMM: 30-265/285.0
SIFKNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNR-TMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQL-FPLLSG
. .. ||   |  |    ..  . |     ..| |. . .|  .. | | || |   .   . |||.||.||.|  ... .  .|  |    | .|   |
tayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgp...lpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

TFSNHGKMFLNNKKV-DSAVAMT---AYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVG---ELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFTS
   . ||  .   .. . |.| |   | |.    | .|. |     ..  | ..   |.     ||   |.||   ..  ..    |.||. |.. .  .
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

MLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRA
 . . .  ...  .|. ..|  |   |..  ||  ..  
tirimenpniemldivremramrfqavqshmqflflyvv
subfamily_PTPRB_pd Subfamily PTPRB 114-348 2.8e-14 47.9 In-house 49-288 (293) alignment 
Range on Protein: 114-348
Range on HMM: 49-288/293.0
KNNPKKSRAPDWPIADNKLIKL----SHAPGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLLSG
. | .| |  .    |.  .||    ...  ..| |  ..  . .|  |.|| |   .   ..|||||.....   ||.    .|   |  .. .|  . 
avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP...lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee

TFsNHGKMFLNNKKVDSAVAMTAYTLEVLPdgCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTN------ENTVLMSMNGIGRAGTMLTLFTSM
.  ..|.. .. .. ..    .  .|..     ...   . ||   | .    |.   |.. |..| ..       . .|     |.||.|| ..| . .
pv.lyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

LSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNK
 .....  |.   |...|| ||  || . .|.  .|...   ...|
qaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPN1_pd Subfamily PTPN1 114-358 6.8e-14 46.3 In-house 30-284 (290) alignment 
Range on Protein: 114-358
Range on HMM: 30-284/290.0
KNNPKKSRAPDWPIADNKLIKLSHAPGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFPLLSG---T
..| .. |  |    |   ||| .|  ..| |. |...| .|  |.|| |   ..  .. ||.|.....  ..|.    .|  ..  .| .|        
penrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGP...lpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

FSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLK-----TN-ENTVLMSMNGIGRAGTMLTLFTSML
  .. |. ..  . ..    |  .||.    . ..   . .|   |      |  . ..  . || .     ..   .|.    ||||.||.  . | ..
lledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

SVQKSKE---VNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKCSDEEVQKKV
 ..|...   |. |. |..||  | ||.  |||..  . |.    |   .|  |||. 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqkrw
subfamily_PTPRA_pd Subfamily PTPRA 115-345 4.4e-13 43.8 In-house 57-295 (330) alignment 
Range on Protein: 115-345
Range on HMM: 57-295/330.0
NNPKKSRAPDWPIADNKLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFPLlSGT
.| .|.| ..    | . . ||.  |    ..| |. .|  .   . | .| |    .  .|||||||.. .  .||.     |      .| .|   |.
enkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk...eetvedfwrmiweqksativmltelkerkeekcaqywPd.eGl

FSnHGKMFLNNKKVDSAVAMT--AYTLEVLPDGC--SNSLLSTVYHLHNWKQKqGL--ENVG--ELVTTVEKVLKTNENT-VLMSMNGIGRAGTMLTLFT
.. .|.. .. ...  .|..|   . .. |||..   .| | . .|.. | .  |.  | .|  .|.  |.|. . . .. |.    |.||.||...| .
vt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda

SMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWF
 .  |.  . |.  |.. .||  |. .|    |.. .....  ..
vlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
Y_phosphatase Protein-tyrosine phosphatase 116-342 6.8e-43 142.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 116-342
Range on HMM: 1-234/235.0
NPKKSRAPDWPIADNKLIKLSHAPG--NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFPLLSGTFSN
| || | .| ...|.. .||.. .|  ..| |  |.  . ....|.|| |   ..  |||||||..||.. .||. .   |  .....| .|  .... .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGKMFLNNK-KVD-SAVAMTAYTLEVLPDGCSN-SLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTN----ENTVLMSMNGIGRAGTMLTLFTSMLSV
.|......| |.     ..| ..||.  .. .. .   ...|..||....  |.. .|. ...|| |..    ...| ....|.||.||...| . . ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMA
.. .||. ..|. .|| .| |.|....|.  ...|..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 116-342 6.8e-43 142.1 In-house 1-234 (235) alignment 
Range on Protein: 116-342
Range on HMM: 1-234/235.0
NPKKSRAPDWPIADNKLIKLSHAPG--NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFPLLSGTFSN
| || | .| ...|.. .||.. .|  ..| |  |.  . ....|.|| |   ..  |||||||..||.. .||. .   |  .....| .|  .... .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

HGKMFLNNK-KVD-SAVAMTAYTLEVLPDGCSN-SLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTN----ENTVLMSMNGIGRAGTMLTLFTSMLSV
.|......| |.     ..| ..||.  .. .. .   ...|..||....  |.. .|. ...|| |..    ...| ....|.||.||...| . . ..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

QKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMA
.. .||. ..|. .|| .| |.|....|.  ...|..
eaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 116-348 2.4e-15 52.0 In-house 1-174 (182) alignment 
Range on Protein: 116-348
Range on HMM: 1-174/182.0
NPKKSRAPDWPIADNKLiklshaPGNFICAAKVDVPEFNRTMIVTQIPDVTvsaNIEDFWRMIFQEEIVSIVIAVmpleCSVTLQQLFpllsgtfsnhgk
| .| | .|..  |. .      . ..| |  .. .  ....|.|| |      ...||.||. .. | .|| .     .     .|.            
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt....eelywpell............

mflnnkkvdsavamtaytlevlpdgcsnSLLSTVYHLHNWKQKQGLEnVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFtsmlsV---QkskEVN
                              | . |. ..|      . . ||.  .|.||. .....   . |.||.||.  ..     .   .   .|.
............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaay.....lmkkl...gvs

PKEILIKLRGERSGLVENADQFNTVHRAMALWFKNK
. |..  .|  |.| |.. .|.  ...|. .....|
leeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 116-188 9.4e-06 19.5 In-house 48-118 (305) alignment 
Range on Protein: 116-188
Range on HMM: 48-118/305.0
NPKKSRAPDWPIADNKLIKLSHA-PGNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVI
. .| |  |    ||. .||  . | ..| |  |  |   . .| || |   .     ||| | .|. . .| .
eagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqap...lektcadfwymclqdkveaifm
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 118-351 7.5e-12 39.5 In-house 57-295 (305) alignment 
Range on Protein: 118-351
Range on HMM: 57-295/305.0
KKSRAPDWPIADNKLIKLSH-APGNFICAAKVDVPEF-NRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLLSGTFSN-H
 | |  | |  |....||.. .| ..| |  | .|   .. .|..| |   .   |..|| |. |. .  ||. .  .|   .   | .|.  |   . .
tknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgp...ldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

GKMFLNN----KKVDSAVAMTAYTLEVlpdGCSNSLLSTVYHLH--NWKQKqGLENVGelVTTVE---KVLKTNENTVLMSMNGIGRAGTMLTLFTSMLS
. . ..|    | ..    .   .|..     | .   .| ||.  .| .. |.  .   .|..|    .  ..   |.    ||||.||....   .  
sgivvenvsgskpmerdaeiqitllnl...tysgdqkmsvrhlqwtewpdr.gvppck..ltslellsairgskvpivvhcsagigrtgtivaieyilek

VQKSKEVNPKEILIK-LRGERSGLVENADQFNTVHRAMALWFKNKCSD
. . |.. |   |.| || .|.  ..|  |.  .|| |  .| .|  .
iaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_PTPN6_pd Subfamily PTPN6 129-349 3.4e-14 47.5 In-house 67-301 (306) alignment 
Range on Protein: 129-349
Range on HMM: 67-301/306.0
DNKLIKL--SHAPG-NFICAAKVD--VPEFNRTMIVTQipdVTVSANIEDFWRMIFQEEIVSIVIAVMPLEC-SVTLQQLFPLLSGTFSnHGKMFLNNKK
|.  ..|  .. || ..| |  ..  |.. ... | ||    .... ..|||||..||.   ||.. . .|       . .|  . . . .||. ..| .
Dhtrvilkepsvpgsdyinanyikkevkgsdksyiatq...gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvs

VDSAVAMTAYTLEVLP-DGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNE--------NTVLMSMNGIGRAGTMLTL---FTSMLSVQKSKE
 .|. . .  .| |   .  ...     || ..| ..   .. | ..  .|.| . .|         .|    .|||| ||.. .      . .     .
eksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

VNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKNKC
.. ...  ..|  |||||  ..|.. |..|.. . ..| 
idiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 131-342 1.3e-12 42.7 In-house 76-288 (319) alignment 
Range on Protein: 131-342
Range on HMM: 76-288/319.0
KLIKLSHAPG----NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVmplecSVTLQQLFPLLSGTFSNHGKMflNNKKVDSA
. .|| .  |    ..| |. |.    .   | .| |       ..||||||.. .. .||.            | .||      ...|.  . . |. .
nvvklerliGeefsdyinasfvtGyqrkdkyiaaqGP...ldntladfWrmiweyncstivllt.....kdkcsqywplkivikeerfkv..kvdsveet

VAMTAYTLEVLPDGCSNSLLS-TVYHLHNWKQKQGLENVGELVTTVEKV------LKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIK
   .   .|.  ||  .   . | .|.  | ..   .   .|.. |.||       . ..| |.    |.||.|. ..| . .  ... | |.  ...  
aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrd

LRGERSGLVENADQFNTVHRAMA
|| .|. ||..  |.  .. |. 
lrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 133-341 7.1e-13 42.5 In-house 60-272 (515) alignment 
Range on Protein: 133-341
Range on HMM: 60-272/515.0
IKL---SHAP-GNFICAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMPLECSVT-LQQLFPLLSGTFSNHGKMFLNNKKVDSAV
.||     .|  ... |...   . ... | .| |     | ..||||...||..  |..     |       . .|   |   . |.. ..   ...  
vklevindnPhsdyfnasyipsfdndkayiasqgPn...kasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleact

AMTAYTLEVLPDgcSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVlKTNEN-----TVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRG
 ..  .|.|| .  ..|   | .|...| .|   ..   |.  . .| |....      ..  . |.||.| ....   .  ..... |.  ... ..| 
ggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirq

ERSGLVENADQFNTVHRAM
.|  ||   .|.  .. |.
krpylvqtqeqyafiygav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 138-352 3.2e-13 44.3 In-house 75-284 (315) alignment 
Range on Protein: 138-352
Range on HMM: 75-284/315.0
APGNFICAAKVDVPEFNRTMIVTQIPDVtvsANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQ-LFPLLsgtFSNHGKMFLNNKKVDSAVAMTAYTLev
   ... |. .|  . .|  | .| | |   | ..||||..|.|.|  ||.     |      .  .|        .||. .  |. .    .|  ||  
phsdyvnanfidGynkkrryiaaqgpnv...asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl..

lpDGCSNSLLSTVYHL--HNWKQKQGLENVGELVTTVEKVLKTNENTV----LMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVEN
     ... . .|. |    | . .  .    |.  . .| . ..|.|    .   .|.||.||..|| . .  ..  . ..  ... ..|  | ..|. 
..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqv

ADQFNTVHRAMALWFknKCSDE
|.|.. .. |.   |   | | 
aeqyqfiydalletf..vcgdt
subfamily_PTPN12_pd Subfamily PTPN12 140-350 1.6e-16 55.0 In-house 68-282 (290) alignment 
Range on Protein: 140-350
Range on HMM: 68-282/290.0
GNFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVT-LQQLFPLLSGTFSNHGKMFLNNKKVDSAV-AMTAYTLEVL
 ..| |  .  .| . . | .| |   ... ..||||||.. ..  .|.| . .|   .  .. .|   ..  ..|.. ..... .     ..  ||.| 
sdYinanfikgvegkleyiaaqgP...LpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkve

PDGCSNSLlsTVYHLHNWKQKQGL---ENVGELVTTVEKVLKTNENTVLM-SMNGIGRAGTMLTL--FTSMLSVQKS-KEVNPKEILIKLRGERSGLVEN
 .. |...  . .| ..|  ..     ... ||...|... ..... ...    |.||.||....    ..|  .|  .|..  .....|| .|. ||  
aqkesrkv..yqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt

ADQFNTVHRAMALWFKNKCS
 .|.. |..|.|  .... .
keqyelvykavaelvqkele
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 141-341 1.7e-17 58.5 In-house 38-238 (250) alignment 
Range on Protein: 141-341
Range on HMM: 38-238/250.0
NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQLFPLlsGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDG
..| |. ... . ... |.|| |   ..| |||||||...|.. .||.     |   | .| .|    .  ..|.. .. .. .    .|  .| .    
dyinasflhgyderkafiatqgP...lqatiedfWrmvleeksgtivmLtnLkesektyhqywPv..ekaekyGdvtvsllskeefadytkrklklskak

CSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNEN-----TVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFN
 ... .   .|  .|  |   |.    .  ..|| .....      ..   .|.||.|. ... . .  ..|.| |.  .....|| .| . ||  .|. 
kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv

TVHRAM
 |....
fvyeii
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 141-342 3.9e-15 50.7 In-house 80-281 (297) alignment 
Range on Protein: 141-342
Range on HMM: 80-281/297.0
NFICAAKVdvPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQLFPllSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDG
... |. |  . ..  .| || |     | ..|||.|...|..  ||.     |     .. ..    . .. |.. .  . |..   .   .|||  . 
Dyvnasfv..kgnkhrlittqmP...mkatvadfWamvldeqvstivmlnddnerdkkcaryWs..dkgvttfGdvsvvllsvsereGfikrelevtkgk

CSNSLLSTVYHLHNWKQKQ-----GLENVGELVTTVEKVLKTNEN--TVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQ
  .  .   |.  .| .|.       . . .|.. |.|. ..|..   ..  ..|.||.| .||.   .  ... |||.  ... ||| ||  ||   .|
akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

FNTVHRAMA
.. |. |. 
ykfvyvavl
subfamily_CG7180_pd Subfamily CG7180 141-341 7.2e-15 49.4 In-house 71-286 (296) alignment 
Range on Protein: 141-341
Range on HMM: 71-286/296.0
NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQLFPLLSgtFSNHGKMFLNNKKVDSAVAMTAYTLEVLPD-
..| |. ||    ..  |||. |   .   ...|||....||| ..|.   . . .   .. .|  |    ..|..|..  ....  ... .|. .    
dYinavyvdsflkkkeyivteap...kketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkki

---G------CSNSLLSTVYHLHNWKQKQGL--E--NVGELVTTVEKVLKTN------ENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKL
   .        .  . ....|  |. .. .      . ||.  |... . .      . .| .| .| .|.|  |..  ..  |.| .||.  | . .|
valteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktl

RGERSGLVENADQFNTVHRAM
| .| .|||| ...  .   .
rrsRpqLvenveeYkyiYdvl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 141-342 5.1e-14 47.1 In-house 70-273 (281) alignment 
Range on Protein: 141-342
Range on HMM: 70-273/281.0
NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPlLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPD
..| |  |.  . ..  |.|| |   | | ...||.|......  ||.    .| . .   . .|    .  . |.. .....  .   .   ....  .
DYinanfvpgykgekeyiatqgP...vPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfklere

GCSNSLLSTVYHlHNWKQKQGLENVGELVTTVEKVLKTN-----ENTVLMSMNGIGRAGTMLTLFTSMLSV-QKSKEVNPKEILIKLRGERSGLVENADQ
.. .  .. . .  .| ..   ..  ||.   ..|||..        |.    |.||.|| ..| . . .| .. .|...|... .|| ||  .|    |
sgetreveqlay.taWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq

FNTVHRAMA
.. |..|. 
yefvykavl
0043147 (Phosphotyrosine protein) phosphatases II 141-338 2.8e-10 35.7 In-house 6-154 (172) alignment 
Range on Protein: 141-338
Range on HMM: 6-154/172.0
NFICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVmPLecsvtlqqlfpllsgtfsnhgkmflnnkkvdsavamtaytlevLPDG
..| |  .|..   .  |.|| |    . ...|||||. .. |  || .  .|                                           | |.
dyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnlt.el...........................................lydp

CSNSLLSTVYHLHNWKQKQGL--ENVGELVTTVEK--VLKTNENTVLMSMNGIGRAGTMLTLFTSMlsvqksKEVNPKEILIKLRGERSGLVENADQFNT
   . |   |. ..|        | . |..  ...  .|. .. ..   . |.||.||.  ..  .      . ... |..  .|  |.| |.| .| . 
ellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

VH
..
ly
0036282 (Phosphotyrosine protein) phosphatases II 141-338 2e-09 32.9 In-house 3-163 (174) alignment 
Range on Protein: 141-338
Range on HMM: 3-163/174.0
NFICAAKVDVPEFNRTMIVTQIPDVtvsaniedFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLlsgtfsnhgkmflnnkkvdsavamtaytlevlpd
..| |  .|. . ..  |..| |          ||.|.... | ..|    . |   .   ...|                                   
dyinaspldlsyitprliagqgpla........fwemlkelgittvvmlleekelglykcinywpe..................................

gCSNSLLSTVYHLHNWKQK--Q--GLENVGELVTTVEKVLKT--NENTVLMSMNGIGRAGTMLTLFTSMLSVQkSKEVNPKEILIKLRGERSGLVENADQ
  ...|  ...... .     .   |. . |.|  ||..|.   .  ..   . |.||.||.  ..  .     .. |.  ... .||  |.| |.. .|
.lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

FNTVH
.  ..
yrfly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 141-346 2.6e-08 28.3 In-house 47-260 (290) alignment 
Range on Protein: 141-346
Range on HMM: 47-260/290.0
NFICAAKVDVPEfNRTMIVTQIPDVTV----SANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQ-----LFPLLSGTFSNHGKMFLNNKKVDSAVAMTA
..| | .| .|. .  .|.|| |   .     . ||.|| |. ||.. ..|      | |  ...      .|   |.  . . . .. |.      .  
dyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

YTLEVLPDGCSNsLLSTVYHLHNWKQKQGLENVGELVTTVEKVLkTNENTVLM-SMNGIGRAGTMLTLFTSMLSVQ-KSKEVNPKEILIKLRGERSGLVE
 .|.|  |.  . .  | . |..|.. .  |.   |.. ..||  ... .|..  ..|| |  .. ..  ..  .  .|..|. ...| .|| .|  .. 
Relvvkfddeee.ftvtHsllkgWnklnvqedtktllsliqkvk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralait

NADQFNTVHRAMALWFK
.| ..  |  .. | ..
salelafvdagivllai
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 142-342 7e-13 43.7 In-house 55-252 (284) alignment 
Range on Protein: 142-342
Range on HMM: 55-252/284.0
FICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVmplecSVTLQQLFPLLSGTFSNHGKMflNNKKVDSAVAMTAYTLEVLPDGC
.| |. .     .   | || |       ..||||||.. .. .||.            | .||      ...|.  . . |. .  ..   .|.  || 
yinasfitGyqrkdkyiatqGP...ldntladfWrmiweyncstivllt.....kdkcsqywplkivikeerfkv..kvdsveeseeyvvrdielsedgk

SNSLLS-TVYHLHNWKQKQGLENVGELVTTVEKV------LKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQF
 .   . . .|.  | ..   .   .|.. |.||       . ..| |.    |.||.|....| . .  ... | |.  ... .|| .|. ||..  |.
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

NTVHRAMA
  .. |. 
kfiysall
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 143-334 2.5e-08 28.0 In-house 78-270 (301) alignment 
Range on Protein: 143-334
Range on HMM: 78-270/301.0
ICAAKVDVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVT-LQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTA--YTLEVLpD
| |  .. .   . .|.|| |   ...  |||| |. | ..  ||.    .|  ..  .. .|.  .   . |.  .. |. .. .       ||||  |
ihanwiptsGhphrfiatqgP...lkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleve.d

GCSNSLLSTV--YHLHNWKQKQGLENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQF
   .    ||  |  ..| ...  .   ||   .| | |...  |.   .||||. ....       |.  .... .| | .|| .|   | .  |.
stgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 144-349 8.8e-15 49.6 In-house 80-292 (325) alignment 
Range on Protein: 144-349
Range on HMM: 80-292/325.0
CAAKVDVPEFNRTMIVTQIPDvtvSANIEDFWRMIFQEEiVSIVIAVMPLECS-VTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCS
 |. .       ... .| |    .| |.|.||.... .  |.|. .  |.       . .|   |   . | . .. . ..         |.|      
nasylrddkkkdvflaaqaPl...tatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG

NSLLSTVYHLHNWK----Q--KQGLENVGELVTTVEKVLKTNE----NTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENAD
...    ..|  |.    |     | .. .|| .|.. ...|       ..  ..|.||.|....|.. .  | .  .|.  . . ||| .|  .|| .|
etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvd

QFNTVHRAMALWFKNKC
|.  .. |..  . .  
qyiliyealveaymsgn
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 149-341 1.1e-08 29.5 In-house 45-236 (239) alignment 
Range on Protein: 149-341
Range on HMM: 45-236/239.0
DVPEFNRTMIVTQipdVTVSANIEDFWRMIFQEEIVSIVIAVMPLECSV-TLQQLFPLLSGTFSNHgKMFLNNKKVDSAVAMTAYTleVLPDGCSNSLLS
|     .. | ||    .|...  |||||..||  . ||.    .|      .| .|  .  . |  .. | . .| .   . ..   .   | ..    
dydgspkayiatq...gcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.rvtlrktevfadyiirtfv..msqvgqteeryv

TVYHLHNWKQKQGLENVGELVTTVEKV----LKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
  ||.  | .|   .    ..    |.    |      |.    |.||.|..| . . .   .| | |.  . .  .| .|  .|. ..|.  .| |.
yqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 149-341 1.2e-08 29.5 In-house 46-237 (239) alignment 
Range on Protein: 149-341
Range on HMM: 46-237/239.0
DVPEFNRTMIVTQipdVTVSANIEDFWRMIFQEEIVSIVIAVMPLECSV-TLQQLFPLLSGTFSNHgKMFLNNKKVDSAVAMTAYTleVLPDGCSNSLLS
|     .. | ||    .|...  |||||..||  . ||.    .|      .| .|  .  . |  .. | . .| .   . ..   .   | ..    
dydgspkayiatq...gcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.rvtlrktevfadyiirtfv..msqvgqteeryv

TVYHLHNWKQKQGLENVGELVTTVEKV----LKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
  ||.  | .|   .    ..    |.    |      |.    |.||.|..| . . .   .| | |.  . .  .| .|  .|. ..|.  .| |.
yqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPRN_pd Subfamily PTPRN 149-342 9.5e-08 26.1 In-house 94-289 (297) alignment 
Range on Protein: 149-342
Range on HMM: 94-289/297.0
DVPEFNRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSVTL-QQLFPLLSGTFSNHGKMFLNNKKVDSA-VAMTAYTLEVLPDgcSNSLL
|    . . | || |   ..... |||.|.... .| ||      | .|.  .. .|       .  .. |  ... .    . .. |  |    |..  
dhdprapayiatqgp...lastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqt..setrt

STVYHLHNWKQKQGLENVGELVT---TVEKVLKTNENT-VLMSMNGIGRAGTMLTLFTSMLSVQK-SKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
 | .|   |....   .   |.     |.|  .    . |. ...| ||.|. . .   .  ..|  ||..    | .|| .|.|||.  |||. .  |.
vtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

A
|
a
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 151-339 1.3e-26 87.0 In-house 111-303 (346) alignment 
Range on Protein: 151-339
Range on HMM: 111-303/346.0
PEFNRTMIVTQIPDVTVSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLSTVY
 .|.. .||.|.|..   . .|||| ||.||.|  . . |       |   ||    | .   ||||.||.. | .     ||.||||.| |.|..  |.
fqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvh

HLHNWKQKQGLENVGELVTTVEKVLKT----NENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHR
|   ||. |   .   ..  . . |      |    ..|. | ||| ...  . ..  ..   | |  ||. ... .| | ||   |. ... 
hhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiya
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 154-347 6.1e-19 63.2 In-house 72-270 (274) alignment 
Range on Protein: 154-347
Range on HMM: 72-270/274.0
NRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECSV-TLQQLFPLLSGT--FSNHGKMFLnnkKVDSAVAMTAYTLEVLPDGCSNSlLSTVY
... . || |   ..  ..||||||.|||.  ||.     |      .. ||   ..    ..|.. .   ||...|    |... |    ...   .|.
skayvatqGP...lpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdvei...kvekiverndysvrklvlkyler.ersvk

H--LHNWKQKQGLENVGELVTTVEKVLKTNENT-------VLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
|    .|  ..  ... .|. .|..| ...|..       |.    ||||.|  ..   ..  ..... |.  .|  .|| .| |.|....|.. .|||.
hywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral

ALWFKN
.|. |.
clylkr
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 154-341 7.9e-07 22.9 In-house 90-275 (439) alignment 
Range on Protein: 154-341
Range on HMM: 90-275/439.0
NRTMIVTQIPDvtvSANIEDFWRMIFQEEIVSIVIAVMPLECSVtlqqLFPLLSGTFsnHGKMFLnnkKVDSAVAMTAYTL---EVLPDGCSNSLLSTV-
..  | ||.|      . .||||.....  | ||     .|        .|  . ..  .| . .   .||  . .  |..    |. .  ..    || 
dklyiatqgpk...kettddfwrlviekktvtivmltnlvesyk....ywpsdaevc..ygdiav...rvdrnielpnyvirgfkvfnerdttekertvl

-YHLHNWKQKQGLE---NVGELVTTVEKVLKTNEN--TVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
 .|   | .|.       | ... ...    ..|    |.    |.||.||...|  ..  ..  ..|. | |.  || .|  .|..  |.  .. |.
qfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 154-340 3.9e-06 21.2 In-house 44-234 (237) alignment 
Range on Protein: 154-340
Range on HMM: 44-234/237.0
NRTMIVTQIPdvtVSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLLSgTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSL-LSTVYH
 .. | .| |   . .  .|||.|..||    ||.    .|   .   . .|      . .|.. .  || .     |  .| .   .  . . |   |.
pkkyiaaqgp...lesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyq

LHNWKQKQGLENVGELVTTVEKVLKTNEN------TVLMSMNGIGRAGTMLTLFtSMLSVQK-SKEVNPKEILIKLRGERSGLVENADQFNTVHRA
.  | ..   ..   |.    .... ..        ..    |.||.| .| .  .||   |  | |.  . .  .  .|  ...  ||.  .|..
ftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid.amlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
0051082 (Phosphotyrosine protein) phosphatases II 157-339 1e-06 23.9 In-house 15-147 (151) alignment 
Range on Protein: 157-339
Range on HMM: 15-147/151.0
MIVTQIPdvtvsanIEDFWRMIFQEEIVSIVIAVMPLECSvTLQQLFPLLSgtfsnhgkmflnnkkvdsavamtaytlevlpdgcsnsLLSTVYHLHNWK
..... |        .||.... .. | .||    . |   .. ...| |.                                     .  . .....|.
lyrsggp.......ladflellkelgiktivnlrseeerg.ycpeylpelg.....................................ievlhipildwp

QKQGLENVGELVTTVEKVLKT-NENTVLMSMNGIGRAGTMLTLFTSMLSvqkskeVNPKEILIKLRGERSGLVENADQFNTVHR
  .  ..  ...  .|..|.. | ...   . |.|| ||.  |.  .|       |.. |.|  .|  | |.|   .||  ...
dpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
0046846 (Phosphotyrosine protein) phosphatases II 167-347 2.4e-14 49.0 In-house 32-175 (176) alignment 
Range on Protein: 167-347
Range on HMM: 32-175/176.0
VSANIEDFWRMIFQEEIVSIVIAVMPLECSVTL-QQLFPLlsgtFSNHGKmflnnkkvdsavamtaytlevlpdgcsnsllstVYHLHNWK--QKQGLEN
.  ...||..|.... |  .|    . | .     ...|.    . ..|                                   |. ..|   .   || 
lprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi.................................qylhlpwpDhgvpdlel

VGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFtsmlSVQKSKEVNPKEILIKLRGERS-GLVENADQFNTVHRAMALWFKN
. ||.  ....|| .....   . ||||.||.. ..     ....| ... |.| ..|  |. | |.. .|   ..... |..|.
llellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefellllkk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 167-347 2.5e-13 44.7 In-house 73-266 (270) alignment 
Range on Protein: 167-347
Range on HMM: 73-266/270.0
VSANIEDFWRMIFQEEIVSIVIAVMPLECS-VTLQQLFPLLSGTFSNH--GKMFLNNKKVDSAVAMTAYTLEVLPDGCSNSLLstVYHLHNWKQKQGLEN
. . ...|||||..|.  .||..    |      .. .|  ...  .   ||.   . .   .    .  |..  .| .. |.   .. ..| ..   ..
lpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpre

VG------ELVTTVEKVLKTNENT------VLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
 .      .|......| ......      .    .|.||.||...| . .  ....|.|.. .|. .|| .|  ||.  .|.. ...|.... . 
edsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
0049260 (Phosphotyrosine protein) phosphatases II 167-338 7.1e-09 31.0 In-house 18-143 (152) alignment 
Range on Protein: 167-338
Range on HMM: 18-143/152.0
VSANIEDFWRMIFQEEIVSIVIAVMPLECSVTLQQLFPllsgtfsnhgkmflnnkkvdsavamtaytlevlpdgcsnsllstVYHLHNWKQKQGLENVGE
 . ...|||||. .  |  ||    .||         .                                             |. ..|      ..   
gpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsql

LVTTVEKV----LKTNENTVLMSMNGIGRAGTMLTLFTSMlsvqksKEVNPKEILIKLRGERSGLVENADQFNTVH
|   .. .    |. .....   . |.||.||.  ..  .      . |...|..  .|  |.| |.| .|   ..
llflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0051429 (Phosphotyrosine protein) phosphatases II 169-347 1.1e-10 37.1 In-house 33-227 (272) alignment 
Range on Protein: 169-347
Range on HMM: 33-227/272.0
ANIEDFWRMiFQEEIVSIVIAVMPLECSVTLQQLFPL-----------LSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVLPD-GCSNSLLSTVYHLHNWK
....||||.  .. | .||    . |.      ...             | .. ..|.... . ..     .. ..|..    . ....  ...| ..| 
ltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwp

QKQGLENVgeLVTTVEKVLKtNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVN--------PKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
     ..   |.. .| .|. ... .   . |..| ||.  |. ..| | ..  |.        . |.. .||  | | |.. .|.  ...|.. ....
dhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 193-346 2.4e-07 24.6 In-house 169-339 (347) alignment 
Range on Protein: 193-346
Range on HMM: 169-339/347.0
LECSVTLQQ--LFPLLSGTFSNHGKMFLNNKKVDS----AVAMTAYTLEVLPDGCSNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNENT-----
. |   |..  .||| .  . |    ..| ..|.        |  ||.||. .|||.. .. ||    |  |.  ...  ... |   .|   ..     
ircesnlhrssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianl

------VLMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFK
      |.|   |. |. |..     .  | . |  .  ... |.| .|.|.   .  .    ||  ...|
eklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 224-360 9e-08 26.2 In-house 168-303 (305) alignment 
Range on Protein: 224-360
Range on HMM: 168-303/305.0
DSAVAMTAYTLEvlPDGCsNSLLSTVYHLHNWKQKQGLENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVN-PKEILIKLRG
.. |  |  ..|    |. ...  | ||  .| ..        ..  .||   .   .|.    ||||.|... |   .  .   . ..  . || |.| 
kakvtetvlvie..gpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkire

ERSGLVENADQFNTVHRAMALWFKNK-CSDEEVQKKVVE
.|   ..  .|.  ||. .  .|..|   ||||..   .
qrnnsiqtdaqylfvhqvilnyfrkkklldeevkeayka
PTPc_DSPc_SM00012 248-342 1.2e-17 59.4 In-house 3-104 (105) alignment 
Range on Protein: 248-342
Range on HMM: 3-104/105.0
TVYHLHNWKQKQGLENVGELVTTVEKVLKT------NENTVLMSMNGIGRAGTMLTLFTSMLSVQKS-KEVNPKEILIKLRGERSGLVENADQFNTVHRA
..|| ..|....  |.. ........| |       ....|... .|.||.||. .| . . ...|. |||. ..|. .|| .|.|.|.. .|.  ..||
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

MA
..
ll
0048076 (Phosphotyrosine protein) phosphatases II 249-341 6.6e-07 24.6 In-house 49-139 (145) alignment 
Range on Protein: 249-341
Range on HMM: 49-139/145.0
VYHLHNWKQ--KQGL-ENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFTSMLsvqksKEVNPKEILIKLRGERSGLVENADQFNTVHRAM
 |.  .|     . | | . |..  .|..|| .....   . |.||.||.  ..  .|     . |.. |.| ..|  |.| |.| .|.. .... 
qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 250-339 9.6e-07 24.2 In-house 52-139 (144) alignment 
Range on Protein: 250-339
Range on HMM: 52-139/144.0
YHLHNWKQKQ--GL-ENVGELVTTVEKVLKTNENTVLMSMNGIGRAGTMLTLFTSMlsvqkSKEVNPKEILIKLRGERSGLVENADQFNTVHR
|.  .|   .   | | . |..  .|..|. .....   . |.||.||. ...  .      . ....|.|  .|  |.| |.| .|.. ...
ylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 283-347 5.8e-07 23.6 In-house 215-279 (287) alignment 
Range on Protein: 283-347
Range on HMM: 215-279/287.0
LMSMNGIGRAGTMLTLFTSMLSVQKSKEVNPKEILIKLRGERSGLVENADQFNTVHRAMALWFKN
.    ||||.|..|.... .   ..  .|..  ..|.||  | .||  . |.  .  |.. ..| 
vhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt