Gene W09C5.7 in Caenorhabditis elegans

Synonym: CELE_W09C5.7, CELE_W09C5.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP200_AA protein Get Run
CeleP200_AA_205-518 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 52-547 1.2e-166 547.5 In-house 6-532 (951) alignment 
Range on Protein: 52-547
Range on HMM: 6-532/951.0
LIGKISF--DEQHFLFFVVDSSVVACYRGTSAESSHSIRRIERVIAINVKSDGSVIKSQITPGSGTKLKQGTEKIMKFFAEKVTKA--------------
.||||..  .|...|..| .||...... ...||.... .||||.........|   ....  . ..|.....||..  .|...|.              
vigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldlsekdskelekeectgliglielegkiivatiegkskvnnkkwdlididssg

--------------EPRPALLDDVLKLFNDsKDFYFCRSRDVTISSQKYFEKREAHTS---EDSFFWNKRMVGNLGEAKISD--KFTCPIMQGYVATSQL
              . .  ||... ||..| ..||.... |.| . || .........   ...||||| .. .| ... ..  .|..|..||.|.|...
ylqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldkefltpviqGfvetkei

EITdqiNAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQRGFKYRPPLIINRSVEETHGVFTEHFKRLK
.|.   .. ...|.|||||..|||.|. |||||. .||||||||||||.. .. |||.|.|||.||||.|.| ||.|.. |.||.|||...|.||||.. 
sie...klkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkkykpkikitrseeetqpaFdehfkeql

AHYDTpLVAVSLVDQRGRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDR
 .|.. .| |.|..|...|  |.... |.. |....||....||.|....| .|.....||.......|..|....|....|...||||.||||.|||||
kkygk.vvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldr

TNLVQGQISLFVVLQQAQRLGIFGPLCEPP-EVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAIN
||.|| .||. |. .| ..||.| | .. . | |.|.....||||||.||.|||||.|||||.||.|||||.||.||||.|.|||||...||..|||.|.
tNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvid

IVTGQTEADENAEEEENEKEEEENISRMVTET
...|.....|..| ....|||.|. .|   | 
lllGklpkqevvelidpkkeekeeelrekeek
Sac_COG5329 52-538 3.3e-112 367.5 In-house 64-536 (1070) alignment 
Range on Protein: 52-538
Range on HMM: 64-536/1070.0
LIGKISFDEQHFLFFVVDSSVVAcyrgtSAESSHSIRRIERVIAINVKSDgSVIKSQITPgsgtkL----KQ-GTEkimkffaekvtkaeprpallDD--
..| | . .. || .. ..| ||         ...| .|. |  |... . .  ...| .          .. . |                    .   
vlGlielegslflivitgkskva.....qvipgetiykilavdfislnnn.kwddeeies.....deasteklrse....................hpcs

VLKLFNDSKDFYFCRSRDVTISSQKY-FEKREAHTS--EDSFFWNKR----MVGNLGEAKISDK-------FTCPIMQGYVATSQLEITDQinaYLTITI
 ||     . ||| .  |.| . ||  .|. |. .   ...|.||.     .. . ....  .|       |  .. .|.. | . ..  .     ..|.
elkkLlsngsFYfStdfditntLqkrlkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkk...tiaLtl

ISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQ-RGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYDTpLVAVSLV
|||||..|||.|.|.||.|. .||||||||| |.   ..  ||.| |||||.||.| ..  . |.. |.||.|.|  .| .||..|   |   .. | |.
ISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGd.vhivNLl

DQRGRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCW-VDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFV
.. ..| .| .|. .|. . .. .... .||.|....  .|.... |.  .|..|.. |.     |.|.... |.||.||||.|||||||..| .||. |
ktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrv

VLQQAQRLGIFGPLCEPpeVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEADENAE
.|.| . ... .   .    ..| ....|||||| || .| || |||...|| | | . | ..|  .|.||.|.    |...|.||....|. . .|. |
lleqfrsikvisaidde..dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeave

EEENEKEEEE
  .. .|  .
lydpineyvn
Syja_N SacI homology domain 52-371 3.6e-74 240.8 Pfam-A 4-318 (319) alignment 
Range on Protein: 52-371
Range on HMM: 4-318/319.0
LIGKISFDEQHFLFFVVDSSVVACYRgtsaeSSHSIRRIERVIAINVKSDGSVIKSQItpgsgtklkQgtekimkffaEKVTKAEPRPALLDDVLKLFnD
..| |.......|... ... || .|      .|.| .|..| .|...|. .  . .          .          || .. .    ||  . ||.  
ilGlirllsesyllvitkrekvakir.....gehpiykiksvefiplnseeeessaie.........e..........ekeeeekeeekllkllkkll.s

SKDFYFCRSRDVTISSQKYFEKRE-A-----------HTSEDSFFWNKRMVGNLGEAK-ISDKFTCPIMQGYVATSQLEITdqINAYLTITIISRRSTRR
|. |||. . |.| | |. .||.| .           .  .. |.||. .. .| |.|   .....|..||.| ....|.    .  ...|.|||||..|
sgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievk..skkkveltLIsRrsvkr

AGARYLRRGIDEASNVANFVETELILNIF----EHELSFVQCRGSIPVFWSQ-RGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYdTPLVAVSLVDQRG
||.||||||||. .|||||||||.|. .     .. .||||.|||.|.||.|  .....|.  |.|| |..  .|..|||.|. .|  . |.|.|....|
aGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLlekkg

RELPLAQRFLEHCVKA-----DDNDVTFFSFDLHQHCRGLNFQ
|| .| ... |.. |      ..... . .||.|..|.| .|.
rEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 52-371 3.6e-74 240.8 In-house 4-318 (319) alignment 
Range on Protein: 52-371
Range on HMM: 4-318/319.0
LIGKISFDEQHFLFFVVDSSVVACYRgtsaeSSHSIRRIERVIAINVKSDGSVIKSQItpgsgtklkQgtekimkffaEKVTKAEPRPALLDDVLKLFnD
..| |.......|... ... || .|      .|.| .|..| .|...|. .  . .          .          || .. .    ||  . ||.  
ilGlirllsesyllvitkrekvakir.....gehpiykiksvefiplnseeeessaie.........e..........ekeeeekeeekllkllkkll.s

SKDFYFCRSRDVTISSQKYFEKRE-A-----------HTSEDSFFWNKRMVGNLGEAK-ISDKFTCPIMQGYVATSQLEITdqINAYLTITIISRRSTRR
|. |||. . |.| | |. .||.| .           .  .. |.||. .. .| |.|   .....|..||.| ....|.    .  ...|.|||||..|
sgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievk..skkkveltLIsRrsvkr

AGARYLRRGIDEASNVANFVETELILNIF----EHELSFVQCRGSIPVFWSQ-RGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYdTPLVAVSLVDQRG
||.||||||||. .|||||||||.|. .     .. .||||.|||.|.||.|  .....|.  |.|| |..  .|..|||.|. .|  . |.|.|....|
aGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLlekkg

RELPLAQRFLEHCVKA-----DDNDVTFFSFDLHQHCRGLNFQ
|| .| ... |.. |      ..... . .||.|..|.| .|.
rEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
subfamily_SAC1_pd Subfamily SAC1 142-524 1e-114 374.7 In-house 68-456 (458) alignment 
Range on Protein: 142-524
Range on HMM: 68-456/458.0
LDDVLKLFNDSKDFYFCRSRDVTISSQKYFEK--------REAHTSEDSFFWNKRMVGNLGEAKISDKFTCPIMQGYVATSQLEITDQinaYLTITIISR
  ..|.|  .|..|||.   |.| | |.  .            .. .. ||||| .. .| . .  ..|. |...|.. ...|..  .    .. ..|||
ylkllelvlksetfYfsytydltnslqrlekvtsaalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnak...eikfilisR

RSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQRGF-KYRPPLIINrSVEETHGVFTEHFKRLKAHYdTPLVAVSLVDQR
||  |||.|| .||.|.  ||||||||| |... ..  |||| |||||..|||..  ||.| . .. . |...  |..|.......|  . | |.||||.
RsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqiely.genvlvnLvdqk

GRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQ
|.|..| ... .   ....... . .|| |..||   ...|..|| ..|..|. .|. ........|..|||||||||||||||||.||  ..  |. .|
GsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkq

AQRLGI--FGPLCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEAD
 ..||.   .  .|  . | .... .||||.| .|.|||||.||| | || | |.|.|...||.||.||||    .| .||..|....|.. ..
leslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrve
subfamily_Synaptojanin_pd Subfamily Synaptojanin 143-531 1.3e-74 243.0 In-house 64-446 (754) alignment 
Range on Protein: 143-531
Range on HMM: 64-446/754.0
DDVLKLFNdSKDFYFCRSRDVT--ISSQKYFEKREA-HTSEDSFFWNKRMVGNLGEAKI-SDKFTCPIMQGYVATSQLEITDQInayLTITIISRRSTRR
 .. ||.. |. |||. |.| .  .. ..  ..|.  ......||||. .  .|   .. .|..  ..| | |    . ....      ...||| |. |
ielkklla.sgtfyfsssadsasrldlslsaqrrkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakq...akaalisrlscer

AGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQRGFKYRP-PLIINRSVEETHGVFTEHFKRLKAHYDTpLVAVSLVDQRGRELP
|| |.  ||...  ||||||||| .. . .. .|||| |||.|.||.| | .     . ..|..| ..  |  |.. ||..| .  | |.|. ... |  
aGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGe.vvivnllGskegeev

LAQRFLEH-CVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEET-LKTIGFcWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQR
| . | .|   .. ..|| | .|| ||...| . .||..|.. . .. |.. .| .. | .||...|.||.|.||.||||||| ||  ..| |. .| . 
lskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasf.flskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlea

LGiFGPLCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTrngerklMGVMKDGYNSASRYYLTHTKDAQRQKAINIVT-GQTEADENAEEEE
|.  .   .  . . ......|  ||| ||. |||| ||.|..        .. .|||  | .|       |...|.||...  |.|  .| |..  
lk.lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgarsvartiqnnfldsskqeaidllllgntyveeladkar
subfamily_FIG4_pd Subfamily FIG4 173-524 1.1e-60 196.6 In-house 179-544 (569) alignment 
Range on Protein: 173-524
Range on HMM: 179-544/569.0
KREAHTSEDSFFWNKRMVGNLGEAKISDKFTCPIMQGYVATSQLEITDQinaYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELIL----N-IF
. .  .... | ||. ..  | .   . ..   |. |.|  |....  .    ...|.|.|||.. ||||.|.||.... .||| |||| |.    .  .
eakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgk...siyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsl

EH--ELSFVQCRGSIPVFWSQR--GFKYRPPLIINRsVEETHGVFTEHFKRLKAHYDTPLVAVSLVDQ---RGRELPLAQRFlEHCVK------ADDNDV
..    |||| |||.|..|||    .. .||. |.. |.    . . ||..|  .| .|.. . || .   | ||  | . | |....       ... .
dsdryssfvqlrGsvPlyWsqdasklvtkPpikidv.vdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleef.eaaieylneflPeekkl

TFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGIFG-PLCEPPEVLVQTM
.. |.|...  .  . . |..| .  |...|. |.    .. | ...|.|.|||||.|||||||  |  |.   .  | ..|||   .  |    .|. .
kyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrll

QTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEAD
. .. | || .. ||.|.   .   | .  ...    .|  .. .|||    .||..|.|||.  |. .  
eelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspr
hSac2 Inositol phosphatase 529-620 1.3e-20 62.1 Pfam-A 2-96 (115) alignment 
Range on Protein: 529-620
Range on HMM: 2-96/115.0
EEENEKEEEENISRMVTETIQFLVPTQQTVIAGWGLINAFQSS---DEIDTVVILTRSNLYIVTYEIDGEKMTDVQIVALEDINTIQTGTSGNNR
....| |.|| ..... .  ....|.....| || |... .|.   .| ..|..||.. ||...|  . ||.|... ..||.|..|. ||  .. 
skdpeiereelreqaiekckklvlpddeeliggWlLvsidhsnktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtysest