Gene Y116A8C.37 in Caenorhabditis elegans

Synonym: CELE_Y116A8C.37, CELE_Y116A8C.37

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP207_AA protein Get Run
CeleP207_AA_65-283 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 53-283 9.9e-38 125.6 In-house 16-249 (308) alignment 
Range on Protein: 53-283
Range on HMM: 16-249/308.0
EEKKEVDKEPWSGEEPAKRMVAngFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLaNGPESFICAAKITVP--DFNRTMIL
...  | ....| .. .|..     . ....   |..  ..|.... |. ....|..| | .|... .   ||| ... ..|.|  ....  ...|..|.
dtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIa

TQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLE---VTLQQILPLLSG-TYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQ
|| |  .    ..|||||.... .  .|    . |   ..  |  ||  | .. .|||..|.....|.  ..| . ||. . |...|.  |..|..||  
tqgPlpn...tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

KRGLEVVTDLVTTMEKVMKV--NENSVLMSMNGTGRAGIF
    . ...|.. .|.| |.  ... | ....| ||.| |
hgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 55-291 3.4e-95 312.9 In-house 2-243 (302) alignment 
Range on Protein: 55-291
Range on HMM: 2-243/302.0
KKEVDKEPWSGEEPAKRMVANgfFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVPDFNRTMILTQVPD
|.|..||.|..|| ||..|..  ..|..|  .||..|..|.....|..||.|..|....|.||....||||.. |.|...|.|..||...|..||.|.|.
kveeekekWveeeeakklvks..ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpk

LSRSPDTADFWRMIHQESIVSVVIAVMPLEV--TLQQILPLLSGTYSTYGKMFVNNKKVESAVGMT-EYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEV
.. ......||||..||.||||||.|.. |.  ||....|..||.|..||||||||.|||.|.... .|..|.||.|||||.|..||...||.||.... 
vdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvk

VTDLVTTMEKV----MKVNENSVLMSMNGTGRAGIFQEKPIEFR
...|..|..||    .|..||.|..|.||.||||.|    . . 
yaeliktaakvfakkikadentvivSknGaGRagafltlavave
0039614 (Phosphotyrosine protein) phosphatases II 60-283 1e-29 99.3 In-house 13-239 (297) alignment 
Range on Protein: 60-283
Range on HMM: 13-239/297.0
KEPWSGEEPAKRMvaNGFFTTTNVGGTFKQTDNFKTPmDSCPSFKNNMHKIRAPDCPIPEEKLVKLANGPE-----SFICAAKITVPDF-NRTMILTQVP
 .|.| .. ....  .  . .| .   |..  ..| .  |.  ...|..| | .|... .   |||   ..     ..|.|  ....|. .|..|.|| |
piplsvldlllll..ekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP

dlsRSPDTADFWRMIHQESIVSVVIAVMPLEVT--LQQILPLLSGtysTYGKMFVNNKKVESAVGMTEYCLEILPDGCSnsLLTTVYHMHNWRQKRGLEV
    .  ..|||||.... . ..|    . |     .|  |  .|   |||...|...|||   |.| . ||. ..|.|  .  |... ..|      . 
...lpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvpps

VTDLVTTMEKVMK------VNENSVLMSMNGTGRAGIF
...|   .|.|..       ..  . ....| ||.| |
lellleflelvrealaelpkggpvlVHCsaGvgRtGtf
0051299 (Phosphotyrosine protein) phosphatases II 61-283 1.5e-33 111.9 In-house 3-236 (288) alignment 
Range on Protein: 61-283
Range on HMM: 3-236/288.0
EPWSGEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLAN----GPESFICAAKITVPDFNRTMILTQVPDL
 ..| || .|.. .     .|..   |..  ....... |. ....|..| | .|..  .   ||| .    .. ..|.|  |......|..|.|| |  
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

SrspDTADFWRMIHQESIVSVVIAVMPLE---VTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPD----GCSNSLLTTVYHMHNWRQKRG
.    ..|||||.... .  .|.   . |   ..  |  ||  |.. |||...|.....|.  ..| . ||. .     |...|.  |..|..||     
n...tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

LEVVTDLVTTMEKVMKV----NENSVLMSMNGTGRAGIF
 . ...|.. ...|.|.    .   | ....| ||.| |
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtf
0043336 (Phosphotyrosine protein) phosphatases II 63-283 4.1e-33 110.5 In-house 2-227 (278) alignment 
Range on Protein: 63-283
Range on HMM: 2-227/278.0
WSGEEPAKRMVANGFFTTTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLANGP----ESFICAAKITVPDFNRTMILTQVPDLSrs
.| .. .|...  ..   | .   |.. ..||... |.  ...|..| | .|... . ..||| . .     ..|.|  .......|..|.|| |  .  
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe..

pDTADFWRMIHQESIVSVVIAVMPLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTT
  ..|||||.... . ..|  . . |   ..  .  .|.. |||...|...|.|.  ..| . ||. . |...|.  |.|| ..|      | ...|.  
.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

MEKVMK----VNENSVLMSMNGTGRAGIF
...|..     |.  . ....| ||.| |
lkavrealedsngpvlVHCsaGvgRTGtf
0040438 (Phosphotyrosine protein) phosphatases II 68-283 6e-37 123.0 In-house 8-226 (317) alignment 
Range on Protein: 68-283
Range on HMM: 8-226/317.0
PAKRMVANGFfttTNVGGTFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLANGP----ESFICAAKITVPDFNRTMILTQVPDlsrSPDTAD
  .......|   | .   |.. ...| .  |. ....|..| | ||... .   ||| . .     ..|.|  ...|...|..|.||.|    .  ..|
alldllksdf...talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...pntved

FWRMIHQESIVSVVIAVMPLEVT---LQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTME
||||.... . ..|  . . |      .|  ||  |.. |||...|.....|   |.| ..||. ..|.|.|.  |..|...|      .  ..|.  .|
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

KVMKV----NENSVLMSMNGTGRAGIF
.| ..    ..  . ....| ||.| |
avrealedpggpvlVHCsaGvgRtGtf
0047943 (Phosphotyrosine protein) phosphatases II 84-283 2.3e-35 117.8 In-house 15-222 (273) alignment 
Range on Protein: 84-283
Range on HMM: 15-222/273.0
GGTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMP
   |..  ..|.... |. ....|..| | .|... .   ||| .|. ..|.|  .......|..|.|| |  .   ...|||||.... .  .|  . .
leefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvrviVmLtel

LE---VTLQQILPLLSGT-YSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMK------VNENSVLM
 |   ..  |  ||  |. . ||||..|.....|.  ..| . ||. . |...|.  |..|...|      . ...|.. .|.|.|       |.  | .
velgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVH

SMNGTGRAGIF
...| ||.| |
CsaGvgRtgtf
0036941 (Phosphotyrosine protein) phosphatases II 85-283 8e-38 125.8 In-house 17-224 (297) alignment 
Range on Protein: 85-283
Range on HMM: 17-224/297.0
GTFKQTDNFKTPMD-SCPSFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPL
  |.. .... ... |. ....|..| | .|... .   ||| ... ..|.|  ....|..|..|.|| |  .    ..|||||.... . ..|  . . 
kefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmltelv

E---VTLQQILPLLSGTYSTYGKMFVNNKKVES--AVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMK------VNENSVLM
|   .. .|  ||  | . |||...|....||.    ..| . ||... |...|.  |..|...|      | ...|.  .|.| |       ..  . .
elgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVH

SMNGTGRAGIF
...| ||.| |
CsaGvgRsgtf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 86-284 3.7e-09 30.6 In-house 27-229 (303) alignment 
Range on Protein: 86-284
Range on HMM: 27-229/303.0
TFKQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLANgpESFICAAKITVpDFNRTMILTQVPdLSRspDTADFWRMIHQESIVSVVIAVMPLEV
 |..  ..  |  |   | .||.| |  |    .   |||..   |.| |. . . | ..  ||||.| ||    .||||.|| .. .  |.. .   | 
efekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd..ssyihasylel.dsskkailtqlp.lsh..taadfwqmiieqkvkcvlllltdsey

---TLQQILPLlSGTYSTYGKMFVNNKKVESAVGMTEYCLEILP--DGCSNSLLtTVYHMHNWRQKRGL-----EVVTDLVTTMEKVMK--VNENSVLMS
     . ..|     .  . . ..   .      .  . | .|   .|  .|.|  |.| ..| ..        ..| ..      . |   .. .| ||
dklggdsvfpr.nqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksfl.hvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvyms

MNGTGRAGIFQ
. | |||| | 
lsgcgragtfa
subfamily_CG7180_pd Subfamily CG7180 88-285 6.4e-07 23.3 In-house 24-242 (296) alignment 
Range on Protein: 88-285
Range on HMM: 24-242/296.0
KQTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLA--NG--PESFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPL
|.| ....    .   |.|. | | ...  .. . | |   .|   . .| |. .     ..  | |. |  .      .|||....| | .||.   . 
kltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkke...tvdefWrlvydeeisavvvLtktf

EVTL--QQILPLLSgtYSTYGKMFVNNKKVESAVGMTEYCLEILPD----------GCSNSLLTTVYHMHNWRQKRGLEVV-TDLVTTMEKVMKVNENS-
. .   .. .|  |     ||..||.  ....   .. . . .                .  . .....  |  .  . .. . |.  ...| .. |.  
dfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

--------VLMSMNGTGRAGIFQE
        | .| .|..|.|..  
edpeegPvvvvssdGasRsGvyla
subfamily_PTPN23_pd Subfamily PTPN23 89-261 1.2e-10 35.7 In-house 26-199 (288) alignment 
Range on Protein: 89-261
Range on HMM: 26-199/288.0
QTDNFKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKIT-VPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIVSVVIAVMPLEVTL
|... ..   |.   | . .| |  |.   ... ||| .. . .| |. .  .     ..| || |     .  .|||.|....    .|. . . |   
qkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPl...qstlnDFWlmvyeqkssviVmllskeelgk

Q---QILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKrGLE-VVTDLVTTMEK
.   .  |   |   ..|.. |  |.|...  . |. |..   . ..    .  ....| .  |.     .|.  ...
pkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpel.GvPasPetllqflde
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 93-209 8.1e-07 22.9 In-house 39-157 (310) alignment 
Range on Protein: 93-209
Range on HMM: 39-157/310.0
FKTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLAN---GPESFICAAKITVPDFNRTMILTQVPdLSRspDTADFWRMIHQESIVSVVIAVMPLEVTLQQ
 . .  .  ..|..||| |  |    ..  |||       | .| |  .    .  |.| .| | |       |||||| ||   |... .   |    .
kqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgp.lqh..tiidfwrmifqeraesilllckvgeegrpk

---ILPLLsGTYSTYGKMFVNNK
     | | |   ||| . | | 
cvgywpsl.gvtetygcirvtnl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 94-282 5.7e-08 27.1 In-house 31-220 (288) alignment 
Range on Protein: 94-282
Range on HMM: 31-220/288.0
KTPMDSCPSFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIVSVVIAVMPLEVTLQQ---I
....|.  || .|  . |  . |  .   ||| . |. .| |  ..   ..| .| .| |          .|.|. .. .  .|.    ||  ...    
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaey

LPLLSGTYSTYGKMFVNNKKVESAVGMT-E-YCLEILPDGcSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENSVLMSMNGTGRAGI
.|.  |    .|..    ||  . .  . .   | |   |  .. .  . |...| ..   |     .  .| . ....  |..| .|.||.| 
fPsklGekarigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 95-285 1.7e-08 28.9 In-house 41-232 (318) alignment 
Range on Protein: 95-285
Range on HMM: 41-232/318.0
TpMDSCPSFKNNMHKIRAPDCPipEEKLVKLANGPES-FICAAKITVPDFNRTMILTQVPdLsrsPD-TADFWRMIH-QESIVSVVIAVMPL--EVTLQQ
. ....  .||    | | |      || .|.. ..| .| |  |     ... | .| | |   |.   |||||.  |.| | |... .     . ...
s.lepvnkaknryanilaydht..rvkLqmlegeegsDyinanyidGyrrkkayiaaqaP.l...petieDfWrmvWeqnsavivmltqeeergkakvhr

ILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENS-----VLMSMNGTGRAGIFQ
  |  |    .|||. |. |.  .   ..   ...  .....|     ||. .| ..  .| ...|.  . .| |....|     |     | ||.|.| 
yWP..skgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfi

E
 
a
0045450 (Phosphotyrosine protein) phosphatases II 97-283 8.1e-30 100.0 In-house 46-251 (307) alignment 
Range on Protein: 97-283
Range on HMM: 46-251/307.0
MDSCPSFKNNMHKIRAPDCPIPEEKLVKLAN-----GPESFICAAKI--------TVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPL
  |. ....|..| | .|... .   ||| .     .. ..| |  .         ..|..|..|.||.|  .     .|||||.... .  .|    . 
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...tvedFwrmlweqgvtvivmltelv

EVTLQ---QILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPD-GCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMK------VNENSVLMS
| . .   |  |.  |.. |||...|.....|   |.| ..||. .  |...|.  |..|...|      . . .|.  .|.|.|       ..  . ..
elgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC

MNGTGRAGIF
. | ||.| |
saGvgRtGtf
0040439 (Phosphotyrosine protein) phosphatases II 99-283 3.7e-29 97.5 In-house 4-196 (249) alignment 
Range on Protein: 99-283
Range on HMM: 4-196/249.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLAN----GPESFICAAKITVPDFNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVIAVMPLEV---TLQQIL
|. ....|..| | ||.....   |||       . ..|.|  |......|..|.|| |    .  ..|||||.... | ..| .  . |    . .|. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP...lpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMK------VNENSVLMSMNGTGRAGIF
||  |.. .||...|....||.  ..| . ||. . ....|.  .......|      . . ||.  .|.|.|       ..  . ....| ||.|.|
pl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf
0046845 (Phosphotyrosine protein) phosphatases II 99-283 1.3e-28 95.6 In-house 21-221 (284) alignment 
Range on Protein: 99-283
Range on HMM: 21-221/284.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLAN-----GPESFICAAKITVP-----DFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLEV---
|.  ...|..| | .|... .   ||| .     .  ..| |  ....     ......|.|| |  .    ..|||||.... .  .|    . |    
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelvengre

TLQQILPLLsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDG-CSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKV------NENSVLMSMNGTG
   |  ||  |.. |||...|.....|   ..| . ||. . | ...|.  |..|...|      . ..||.. ...| ..      ..  | ....| |
kcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RAGIF
|.| |
RtGtf
0042113 (Phosphotyrosine protein) phosphatases II 99-283 9.4e-27 89.4 In-house 2-193 (245) alignment 
Range on Protein: 99-283
Range on HMM: 2-193/245.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLANGPES----FICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLE---VTLQQIL
|. ....|..| | .|... .  .||| . ...    .| |  ..........|.|| |  .   ...|||||.... | ..|    . |   |. .|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqyw

PLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLE---VVTDLVTTMEKVMK--VNENSVLMSMNGTGRAGIF
||  |.. |||...|.....|.  ..| . ||. ..|.. |.  ..|| ..|      .    . |..  ..|...   |.  . ... | ||.| |
pl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf
0037934 (Phosphotyrosine protein) phosphatases II 99-283 1.1e-25 86.1 In-house 3-195 (243) alignment 
Range on Protein: 99-283
Range on HMM: 3-195/243.0
SCPSFKNNMHKIRAPDCPIPEEKLVKLaNGpESFICAAKITVPDfnrTMILTQVPDLSRSPD-TADFWRMIHQESIVSVVIAVMPLEVTLQQILPLLSGT
|......|..| | .|..  .   ||| .| ...|.|  |.|..   ..|.||.|  .   | .|.||||.... | ..|    . | . ..  .. .|.
siallpenlsknrysdilpydhsrvkl.eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

YsTYGKMFVNNKKVESAVGMTEYCLEILPDG-CSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNEN------------SVLMSMNGTGRAGIF
. |||...|.....|.  ..| . |.. . .    ..| . || ..|      . ..||.  ...| .. |.             ... . | ||.| .
v.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl
DSPc_SM00195 100-283 4.6e-30 100.2 In-house 20-212 (263) alignment 
Range on Protein: 100-283
Range on HMM: 20-212/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLANGP----ESFICAAKITVPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIVSVVIAVMPLE---VTLQQILP
.  .|.|..| |  .... ... ||| . .    ...|.|  |.... ....|.|| |    .   .|||||. .| .  .|. ... |    . ..  |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp

LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLE---VVTDLVTTMEKVMKV-NENSVLMSMNGTGRAGIF
  ||...|.||. |....||.    .. . ||.  .|....  .|.|...|| ..   .    |..|. ...|  .  ..  | .. .| ||.|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf
PTPc_SM00194 100-283 4.6e-30 100.2 In-house 20-212 (263) alignment 
Range on Protein: 100-283
Range on HMM: 20-212/263.0
CPSFKNNMHKIRAPDCPIPEEKLVKLANGP----ESFICAAKITVPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIVSVVIAVMPLE---VTLQQILP
.  .|.|..| |  .... ... ||| . .    ...|.|  |.... ....|.|| |    .   .|||||. .| .  .|. ... |    . ..  |
eaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekcdrywp

LLSGTYSTYGKMFVNNKKVESAV-GMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLE---VVTDLVTTMEKVMKV-NENSVLMSMNGTGRAGIF
  ||...|.||. |....||.    .. . ||.  .|....  .|.|...|| ..   .    |..|. ...|  .  ..  | .. .| ||.|.|
eesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 100-284 3e-08 27.9 In-house 27-217 (283) alignment 
Range on Protein: 100-284
Range on HMM: 27-217/283.0
CPSFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVP---DFNRTMILTQVPdLSRSpdTADFWRMIHQESIVSVVIAVM---PLEVTLQQILPL
. | ..| .| |  .    . . |.| . ....| |. |.|    . ..  | .| | | |     |||.|...| |...|.       |..   |  | 
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsP.ldrt..vvdfWkmvfdekitaivmltklqedlrikCsqyWPk

lSGTySTYGKMFVNNKKVESAVGMTEYCLEILPD-GCSNSLLTTVYHMHNWRQKRGLEVVTDLVTtMEKVM----KVNENSVLM-SMNGTGRAGIFQ
  |.   ||.. |  .|  .   ..   | .  .  . ..|| . | . .| .     ..  ||  ..||.    . ..  ...   .| ||...| 
.rGs.edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqteskkgPivvhCstgiGrtavfi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 101-283 5.2e-07 23.9 In-house 49-229 (315) alignment 
Range on Protein: 101-283
Range on HMM: 49-229/315.0
PSFKNNMHKIRAPDCPIPEEKLVKLANGpESFICAAKITVPDFNRTMILTQVPDLSRspdTADFWRMIHQESIVSVVIAVMPLEVTLQQILPLLSGTYST
   ||  ..| | |   ..  |..  ..   .. |. |   . .|  | .| |  .      ||||....| |  .|.     |   ..          .
nkqknryiniiaydksrvqlpllendph.sdyvnanfidGynkkrryiaaqgpnvas...vkdfwrlvfeedigkivmltnlvegekrkaekywpdkkvi

YGKMFVNNKKVESAvgmTEYCLEILpDGCSNSLLTTVYHMH--NWRQKRGLEVVTDLVTTMEKVMKVNENSVL----MSMNGTGRAGIF
|||. |  |. |     |||.   |    ... . .|. .|   | .    .  . |.  . .|.. ..|||        .| ||.| |
yGkitvtrkseevn...teytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtf
0045098 (Phosphotyrosine protein) phosphatases II 102-283 1e-12 43.5 In-house 29-223 (278) alignment 
Range on Protein: 102-283
Range on HMM: 29-223/278.0
SFKNNMHKIRAPDCPIPEEKLVKlangpeSFICAAKITVPdfNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVIAVMPLEVT---LQQILPllSGTY
 . .|..| | .| .  .   ||       .| |  |...  ....|.|| |       .||||||.... | ..| .   .| .     |  |  .| .
lylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggs

STYGKMFVNNKKVESAVGMTEYCLEILPD----GCSNSLLTTVYHMHNWRQKRGLEVV--TDLVTTMEKVMK-----------------VNENSVLMSMN
 |||...|.....|    .|   |..           |.  |..|...|      .    . .   .| . .                  ..  .   . 
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GTGRAGIF
| ||.| .
GvgRtGtl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 102-267 6e-06 20.4 In-house 31-201 (285) alignment 
Range on Protein: 102-267
Range on HMM: 31-201/285.0
SFKNNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVPDFNR-TMILTQVPdLsrsP-DTADFWRMIHQESIVSVVIAVMPLEVTLQQI---LPLLSG
... |    |  |    ||  | | |    .| |. . .|  .. | | || | |   |   .|||.||.|| |  |.. .  .|  ...     |   |
ayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgp.l...petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

TYSTYGKMFV--NNKKVESAVGMTEYCLEIL--PDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNE
    .||  .   . | |.  |    .| ..   | .|. |     ..  | ..   |    ..   . | ||| 
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp
subfamily_PTPRK_pd Subfamily PTPRK 104-283 4.9e-09 30.4 In-house 41-227 (314) alignment 
Range on Protein: 104-283
Range on HMM: 41-227/314.0
KNNMHKIRAPDCPIPEEKLVKLAN---G-PESFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLEVTLQQILPLLSGTYS
..| .| |  |   ..  .|.|          .| || |      .  | || |  .    ..||||....|   |.|.     ||.  . |       .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe...tvkdfWrlvydencasivmltelvevgrvkClkyWPedte

TYGKMFVNNKKVESAVGMTE--YCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENS----VLMSMNGTGRAGIF
.||.. |.  ..|    .    . .| |  | ..  .   ..  .| .       | |.. . .| | .|..    |.  ..|.||.|.|
vygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 104-283 3e-07 24.8 In-house 45-229 (288) alignment 
Range on Protein: 104-283
Range on HMM: 45-229/288.0
KNNMHKIRAPDCPIPEEKLVKLANGPE----SFICAAKITVPDFNRTMILTQVPDLSRspdTADFWRMIHQESIVSVVIaVMPL----EVTLQQILPLlS
 .| .| | ..    .|| ||| ...|     .| |. | . . ... | || |  .      |||...... .  .|  .  |    . . ..  |  .
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladt...vndfWelvyenktstivm.ltelveggktkCeeYWPd.a

GTYSTYGKMFVNNKKVESAVGMTEYCLEILpdGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENS----VLMSMNGTGRAGIF
..   ||.. |  ....    ...  |..      . | .| |.   | ..   |  ..|.  ...|   |..     .   ..| ||.|.|
dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtF
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 105-283 6.1e-08 27.0 In-house 46-228 (287) alignment 
Range on Protein: 105-283
Range on HMM: 46-228/287.0
NNMHKIRAPDCPIPEEKLVKLANGPESFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLEVTLQQILPLLSGTY-STYGK
.| .| |  .  .|... | | .  . .| |. |     ..  |... |  .      .||..|... .  .|. .   | . ..     . .   ..|.
qnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfn...tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGe

MFVNNKKVESAVGMTEYCLEILPDG-CSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENSVLM-----SMNGTGRAGIF
  ..  . |   |..|  ||.  ..  .. .  . |.. || ... ..     .  .|. .| .  .          .. ||...|
yniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamf
subfamily_Ptp69D_pd Subfamily Ptp69D 105-283 6.9e-08 27.0 In-house 47-236 (307) alignment 
Range on Protein: 105-283
Range on HMM: 47-236/307.0
NNMHKIRAPDCPIPEEKLVKLAN----GPESFICAAKITVPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIVSVVIAVMPLEVTLQQILPLLS-GTYS
.|  | | .|    ... |||..       ..| |  |   . ... |  | |         |||||| . ..  .|.     | . ...    .  .  
enalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv...eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedev

TYGKMFVNNKKVESAVGMTEYCLEILPDG-CS----NSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKV---NENS-VLMSMNGTGRAGIF
 ||.. |.  . |..   ..  |..   . .|    .|   . ||  .|.     || . |.  .|.| ..   |.   |.   .|.||.|||
qygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif
Y_phosphatase Protein-tyrosine phosphatase 106-283 1.4e-27 92.1 Pfam-A 1-187 (235) alignment 
Range on Protein: 106-283
Range on HMM: 1-187/235.0
NMHKIRAPDCPIPEEKLVKL--ANGPESFICAAKITVPDFNRTMILTQVPDLSRSpdtADFWRMIHQESIVSVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... |||   .||. .| |  ..  . ....|.|| |  |     .|||||. || . ..|. .   |   ....|  |  .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKMFVNNK-KVE-SAVGMTEYCLEILPDGCSN-SLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVN----ENSVLMSMNGTGRAGIF
||...|..| |..    ..| . ||.  .. .. .  ....|..|| ..   | ...|. ...|| | .    .. | ....|.||.|.|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtf
Y_phosphatase Protein-tyrosine phosphatase 106-283 1.4e-27 92.1 In-house 1-187 (235) alignment 
Range on Protein: 106-283
Range on HMM: 1-187/235.0
NMHKIRAPDCPIPEEKLVKL--ANGPESFICAAKITVPDFNRTMILTQVPDLSRSpdtADFWRMIHQESIVSVVIAVMPLE---VTLQQILPLLSGTYST
|..| | .|... ... |||   .||. .| |  ..  . ....|.|| |  |     .|||||. || . ..|. .   |   ....|  |  .... |
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGKMFVNNK-KVE-SAVGMTEYCLEILPDGCSN-SLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVN----ENSVLMSMNGTGRAGIF
||...|..| |..    ..| . ||.  .. .. .  ....|..|| ..   | ...|. ...|| | .    .. | ....|.||.|.|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtf
0041856 (Phosphotyrosine protein) phosphatases II 106-283 4.5e-06 21.9 In-house 1-126 (182) alignment 
Range on Protein: 106-283
Range on HMM: 1-126/182.0
NMHKIRAPDCPIPEEKLvklangPESFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVmplevtL----Qqilpllsgtysty
|..| | .| . ..  .      . ..| |  .  .  ....|.||.| ||   ..|||.||.... | ..| .                          
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt......eelywp.............

gkmfvnnkkvesavgmteycleilpdgcsN--SLLTTVYHMHNWRQKRGLEvVTDLVTTMEKVMKVNENSVLMSMNGTGRAGIF
                             .    | . |. ..|      . . .|.  .|.| . ... .   . | ||.| .
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 109-271 8.9e-07 23.0 In-house 49-220 (290) alignment 
Range on Protein: 109-271
Range on HMM: 49-220/290.0
KIRAPDCPIPEEKLVKLA------NGPESFICAAKITVPDFNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVIAVMP---LEVTLQQILPLLsGTYS
. |  .. ..... . |       . ....| |. |     ..  |.|| |    |   .|||..| ||..  .|. .      .|. ||  |   .| .
lnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgp...vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka

tYGKMFVNNKKVESAVGMTEYCLEILPDGC-SNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKV----NENSVL
 ||.. ..  . |.  ...|  ||.  .    ..   | |.. || ..  ..  .  ....|...|      ..|..
.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsiv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 123-283 3e-09 31.2 In-house 61-227 (315) alignment 
Range on Protein: 123-283
Range on HMM: 61-227/315.0
VKL---ANGPE-SFICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLE---VTLQQILPLLSGTYSTYGKMFVNNKKVESAV
|||    . |.  .| |..|   | ... | .| |  .      |||||. || . ..|.     |   .  .|  |   .    .|.. |.  ..|.  
vkleviddsPdsdyinasyiksvdddkayiasqgPlka...svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadt

GMTEYCLeILPDGcSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVM---KVNENSVLM-SMNGTGRAGIF
...   | .. ..  .|   | .....| .|   . .. |.  . .|    . .| |.|.  . |.||.|..
dgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 123-283 1.9e-08 27.9 In-house 60-226 (515) alignment 
Range on Protein: 123-283
Range on HMM: 60-226/515.0
VKL---ANGPES-FICAAKITVPDFNRTMILTQVPDLSrspDTADFWRMIHQESIVSVVIAVMPLEV---TLQQILPLLSGTYSTYGKMFVNNKKVESAV
|||    . |.| .. |..|   | ... | .| |  .    . ||||.. || .  ...     |       .  |   |    .|.. |.   .|.  
vklevindnPhsdyfnasyipsfdndkayiasqgPnka...svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleact

GMTEYCLEILPDgcSNSLLTTVYHMHNWRQKrGLEVVTDLVTTMEKVMKVNENS-----VLMSMNGTGRAGIF
|..   |..| .  ..|   | .|...| .| | .  |  .  . | .| ...      ..  . | ||.|..
ggikrkltvlkg..ddsrtvtqfhfteWPdk.GvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 126-296 2.2e-10 34.6 In-house 61-230 (281) alignment 
Range on Protein: 126-296
Range on HMM: 61-230/281.0
AN-GPESFICAAKITVPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIVSVVIAVMPLEVTLQQ---ILPLLSGTYSTYGKMFVNNKKVESAVGMTEYC
 |     .| |  |  | ..|  |||| |        ||||||| ||   ..|. .  ||   ..    .|  .     . |. |. .       .    
pnknstdyihanyirspflkrgyiltqgpk...ketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttr

LEILPDGcsNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENSVLMSMNGTGRAGIFQEKPIEFRNIHTH
|..  .|  .. | | .  ..| . .  |    ..  . |.       |.    | ||.| .    | .. ||.|
lnlsyeg..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihsh
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 127-283 1.1e-08 29.6 In-house 75-234 (297) alignment 
Range on Protein: 127-283
Range on HMM: 75-234/297.0
NGPES-FICAAKitVPDFNRTMILTQVPDlsrSPDTADFWRMIHQESIvSVVIAVMPLEVTLQQILPL-LSGTYSTYGKMFVNNKKVESAVGMTEYCLEI
. |.| .. |.   |. ..  .| || |        ||||.|. .| . |... .  .. . ..        . .|.|.. |  . |..  |. .  ||.
ddpdsDyvnasf..vkgnkhrlittqmPm...katvadfWamvldeqv.stivmlnddnerdkkcaryWsdkgvttfGdvsvvllsvsereGfikrelev

LPDGCSNSLLTTVYHMHNWRQKR-----GLEVVTDLVTTMEKVMKVNEN-SVL-MSMNGTGRAGIF
  .   .  .   |.  .| .|        . . .|.. ..|. . |..  .|   ..| ||.|..
tkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl
subfamily_PTPN12_pd Subfamily PTPN12 128-282 1.4e-07 25.7 In-house 66-223 (290) alignment 
Range on Protein: 128-282
Range on HMM: 66-223/290.0
GPESFICAAKITVPDFNRTMILTQVPdLSRSpdTADFWRMIHQESIVSVVIAVMPLEVTL---QQILPLLSGTYSTYGKMFVNNKKVESAV-GMTEYCLE
  ...| |  |  .. . . | .| | |..     |||||| . ..  ||.| . .|.     ..  |   ..  ..|.. |.... .    ...  .|.
egsdYinanfikgvegkleyiaaqgP.Lpkt..lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLk

ILPDGCSNSLltTVYHMHNWRQK---RGLEVVTDLVTTMEKVMKVNENSVLM-SMNGTGRAGI
.  .. |...  . .| ..|  .   .. . . .|....... . ... ...    | ||.|.
veaqkesrkv..yqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 129-283 4.3e-08 27.6 In-house 73-233 (305) alignment 
Range on Protein: 129-283
Range on HMM: 73-233/305.0
PESFICAAKITVPDFNRTMILTQVPdLsrSPDTADFWRMIHQESIVSVVIAVM---PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEIL
 . .| |. .   . . . |..| | |      |||||.| .| ....|. .      .   .|  |   .    .|.. |. |  ..| . .|  |.| 
dsdyinasyvdgykrkkkyivaqgP.l..kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkis

P-DGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENS-----VLMSMNGTGRAGIF
  |. ..|   . |.. .| ..   .  | |.. ...|.|  ...     .    .| ||.|.|
iededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 130-283 5.7e-09 30.6 In-house 84-240 (298) alignment 
Range on Protein: 130-283
Range on HMM: 84-240/298.0
ESFICAAKITVPDFNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVIAVMPLEV---TLQQILPllSGTYSTYGKMFVNNKKVESAVGMTEYCLEILP
  .| |. .   . . . |.|| |     . ..|||||. .| | ..|.     |.   . ..  |  .    |||.. |. .. |.   ..   |..  
sdYiNAsflhaykgrnafiatqaP...ltetvedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvsllskeefadlivrklkvsk

DGCSNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNENSV-----LMSMNGTGRAGIF
   ...      |. .| .|   |. | ... ..|| . ....      .   .|.||.| |
kkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 132-283 6.4e-10 33.6 In-house 39-192 (250) alignment 
Range on Protein: 132-283
Range on HMM: 39-192/250.0
FICAAKITVPDFNRTMILTQVPdLsrSPDTADFWRMIHQESIVSVVIA--VMPLEVTLQQILPLlsGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGC
.| |. . . | ... | || | |  .. . |||||. .| . ..|.   .   | | .| .|    .  .||.. |. .. |    .|   | .     
yinasflhgyderkafiatqgP.l..qatiedfWrmvleeksgtivmLtnLkesektyhqywPv..ekaekyGdvtvsllskeefadytkrklklskakk

SNSLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNEN-----SVLMSMNGTGRAGIF
... .   .|  .|  |   || |  .  ..|| . ...      ..   .|.||.| |
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 132-283 1.2e-07 26.1 In-house 78-233 (319) alignment 
Range on Protein: 132-283
Range on HMM: 78-233/319.0
FICAAKITVPDFNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVI---AVMPLEVTLQQILPllSGTYSTYGKMFV--NNKKVESAVGMTEYCLEILP
.| |. |   . ..  | || |    .  . |||||. .| .  ||.    | .|.| |... |  . .. .||.. |  ....  . . . . .|... 
yinasfidgyqerekfiatqaP...lentiedfWrmvWeeessivvmltklveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkks

DGCSNsLLTTVYHMHNWRQKRGLEVVTDLVTTMEKVMKVNEN-----SVLMSMNGTGRAGIF
.        . ..  .| ..   |  | |.  .... |  |.      |    .| || | |
sevet.RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 132-283 4.6e-06 21.3 In-house 55-205 (284) alignment 
Range on Protein: 132-283
Range on HMM: 55-205/284.0
FICAAKITVPDFNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSN
.| |. ||    .   | || |   .    ||||||| .  . ..|.     .    |  ||   .  ..... |. . || .  ..   .|.  ||  .
yinasfitGyqrkdkyiatqGP...ldntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveeseeyvvrdielsedgkek

SL-LTTVYHMHNWRQKRGLEVVTDLVTTMEKV------MKVNENSVLMSMNGTGRAGIF
     . .|.  | ..   .  .||.. ..||      .. ..| |.    |.||.|..
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 132-283 9.2e-06 20.2 In-house 91-241 (319) alignment 
Range on Protein: 132-283
Range on HMM: 91-241/319.0
FICAAKITVPDFNRTMILTQVPdlsRSPDTADFWRMIHQESIVSVVIAVmplEVTLQQILPLLsgTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSN
.| |. .|    .   | .| |   .    ||||||| .  . ..|.     .    |  ||   .  ..... |. . || .   .   .|.  ||  .
yinasfvtGyqrkdkyiaaqGP...ldntladfWrmiweyncstivllt...kdkcsqywplk..ivikeerfkvkvdsveetaeyvvrdielsedgkek

SL-LTTVYHMHNWRQKRGLEVVTDLVTTMEKV------MKVNENSVLMSMNGTGRAGIF
     | .|.  | ..   .  .||.. ..||      .. ..| |.    |.||.|..
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 139-283 4.8e-18 58.9 In-house 109-259 (346) alignment 
Range on Protein: 139-283
Range on HMM: 109-259/346.0
TVPDFNRTMILTQVPDLSRSPDTADFWRMIHQESIVSVVIAVM--PLEVTLQQILPLLSGTYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTT
 . .|.. .|..|.|..       ||| ||.|| |  | . |    |  |   ..    | |   ||||.||.. . .    || .|.||.| |.|..  
vifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicq

VYHMHNWRQKRGLEVVT---DLVTTMEKVMKVNEN-SVLMSMNGTGRAGIF
|.|   |.. .          ..  .    .|..    ..|. |.|||  |
vhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsf
subfamily_PTPRD_pd Subfamily PTPRD 159-283 5.4e-07 23.6 In-house 102-231 (564) alignment 
Range on Protein: 159-283
Range on HMM: 102-231/564.0
PDTADFWRMIHQESIVSVVIAVMPLEV---TLQQILPLLsGtYSTYGKMFVNNKKVESAVGMTEYCLEILPDGCSNSLLTTVYHMHNWRQKRGLEVVTDL
. ..|||||. .. . ..|.     |     ...  |   |   |||.. |. .. |    ..   ...     |.|   . .|  .| ..   |  |.|
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatsl

VTTMEKVMKVNENS----VLMSMNGTGRAGIF
.. ..|| ..||.     |    .| || |.|
LdlirkvralnepdagPivVhCSaGVGRTGtf
subfamily_PTPRA_pd Subfamily PTPRA 160-283 5e-06 20.6 In-house 113-245 (330) alignment 
Range on Protein: 160-283
Range on HMM: 113-245/330.0
DTADFWRMIHQESIVSVVIAVMPL---EVTLQQILPllSGTYSTYGKMFVNNKKV--ESAVGMTEYCLEILPDGC--SNSLLTTVYHMHNWRQKrGLEV-
   |||||| .    ..|.        |   .|  |  .    |||.. |. ...    .. . ..... |||..   .| | . .|.. | .  |. . 
tvedfwrmiweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfe

VTDLVTTMEKVMKVNE---NS-VLMSMNGTGRAGIF
   ..  ..|| |.|.   .. |.    |.||.| |
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtf