Gene Y22D7AR.7 in Caenorhabditis elegans

Synonym: CELE_Y22D7AR.7, Y22D7AR.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP212_AA protein Get Run
CeleP212_AA_445-706 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 433-651 1.4e-17 58.7 In-house 9-218 (288) alignment 
Range on Protein: 433-651
Range on HMM: 9-218/288.0
FEKDEKLTSKSPTEVLKEYVTkLLAKDSEKIKSVGMTDyVKKHSLEQREELPLVmATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLhkildk
 .|  |   .. |.. .|| . | | ...| ...|    | ..    |. ||.   .|| |.      ..|.  |. |.  ..  . | ||.||      
vakvakksarnrtgfseeyns.Laalektksvtagrla.vnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl......

ASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsADGIVKIGGFKISCCDMEEDEDVEERTLVVQyEKEKEFTVTHHLYKSWSMCSVPENS
|.|| .||  | ..... |||| .. |.. .      .|.|. ||  .. | ...   . .| ||. .|.| ..  |..|...|.. |..|.  .|||..
adtvndfWelvyenktstivmltelveggkt...kCeeYWPd.adkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPesk

KTLLKLIKNVKCSKT----PVIVH
. ||.|...|| ...    |.|||
apllellrqvkvanqadtgpiivh
0045450 (Phosphotyrosine protein) phosphatases II 438-703 2.5e-37 124.7 In-house 20-303 (307) alignment 
Range on Protein: 438-703
Range on HMM: 20-303/307.0
KLTSKSPTEVLKEYVtKLLAKDSEKIKSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSR-LTSDFFHANRIKCP---------NGLQLILTQSPLHK
.|. ...| .|||.  |||    . . .  .. ... ... .  . ..   ||| |.. ...  .||...|. ...|         .... |.||.||..
lllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

ildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanWNRMFCKYFPESaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY--EKEKEFTVTHHLYKSWSMC
      || .||. .....||.|||| .  |    .... ..|.|.. .. . .| |.. . ..|.....  ||| |..  ......||||. |..|   
......tvedFwrmlweqgvtvivmltelvel...grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

SVPENSKTLLKLIKNVKC------SKTPVIVH---GISR-----NIDLGYQMFALNKK---TTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
.||.. ..||..|. |.       ...||.||   |..|      ..| ....  ...    .. ...| ||... | |  |  | | .. ....
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 438-680 7.4e-21 69.0 In-house 20-259 (290) alignment 
Range on Protein: 438-680
Range on HMM: 20-259/290.0
KLTSKSPTEVLKEYVTKLLAKDSEKIKSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGsrlTSDFFHANRIKCPNGlQLILTQSPLhkildkASTVFK
. ..|.. |. |||..||      .     . |   .   ..  ...    ||| |.  .     |. ||| .|  .   .|||| .|      ..||. 
dvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGy...dGdyvhanyvkGlka.mfiltqGal......kdtvid

FWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADGIVKIGGFKISCCDM-EEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLL
.|  | ||.|. |||| .. |.    .    .|.|| .  .. .| . . |.   ..|...  .|| |.  .. ||  . |.  |||   ||.  . .||
iwrmvlqekvaaivmlceliedG...kakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

KLIKNVKCSKTPVIVH---GISR-----NIDLGYQMFALNKKTTFVSVLKSLR
.... ..    ||.||   || |      |. | |..   |.   . . ..||
rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 440-734 2e-118 389.8 In-house 2-289 (290) alignment 
Range on Protein: 440-734
Range on HMM: 2-289/290.0
TSKSPTEVLKEyvtkllakdsekiksvgmTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGLQLILTQSPLHKI-LDKASTVFKF
.||..|.||..                  |||||||...||.|.|||.||||.|...|.|...|..||||..|||||.|||||||..||  ...||..||
rskestavllk..................tdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekf

WWAVRQERVTHIVMLGQVNEEDANWNRMFCK-YFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKL
||...||.|...|||....|..||.... |. |.|||.....|..|....|...|...|||.|.|||....|.||||||.|.|.|....|.|..||||.|
wwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsl

IKNVKCSKTPVIVH---GISRN-----IDLGYQMFA-LNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAYDPTAVPDDITKIMNYLTEAF
|..||.||||||||   ||||.     |.||||..| .........|||.||.... ......|..|...||...|.|..|..| .....|.... .|..
iqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeekety

TTWFKI
......
kkikql
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 440-652 3.8e-14 47.1 In-house 17-226 (305) alignment 
Range on Protein: 440-652
Range on HMM: 17-226/305.0
TSKSPTEVLKEYVTKLLAKDSEKIKSVGMTdyvKKHSLEQREELPLVMATRVPLnvHGsRLTSDFFHANRIKCP-NGLQLILTQSPLHKildkasTVFKF
  |.|. . .|.|.    .| ||.|.   .   ...  ..  ..  .   || |  .|     .. ||| .  | |  ..| ||.||.|      |   |
lekgpaglraefvamkrfndfekmkafkea...qeagknrykdvgcldnnrvkl..eg.pwpheyihanyvstptnpkrfictqaplek......tcadf

WWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESADGIVK--IGGFKIS---------CCDMEEDEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSV
|.   |..|  | || .. |  |   .  ..||.   . ...   .| |||             . . .|.|  ||..   ||   |||. .  |    |
wymclqdkveaifmlcnllekga...kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PENSKTLLKLIKNVKCSKTPVIVHG
|    ..|.|... . || |..|| 
paadlailellekarpskgpivvhc
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 445-694 4.2e-14 47.1 In-house 19-273 (290) alignment 
Range on Protein: 445-694
Range on HMM: 19-273/290.0
TEVLKEYVTKLLAKDSEKIKSVGMTDyvkKHSLEQREELPLVM-ATRVPLNVHGSR--LTSDFFHANRIK-CPNGLQLILTQSPLHKildkasTVFKFWW
.|  ..  ..| . .||.   ||.|    . .| .| .  .|    |..|.  ...   | .. .|  ||   .  | |.||.|...      |. .|| 
negfrnqfkmldsgesehtvtvglts...snkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn......tlvdFWk

AVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESaDGIVkIGGFKISCCDMEEDEDVEERTLVVQYEKE--KEFTVTHHLYKSWSMCSVPENSKTLLKLI
 . ||.|| |||| ...||.        .|.|.| |    .| |.|   . |. ..  ||.| |. ...  .. .||..  ..|      .| .| | .|
liwqekvtiivmltniieegk...vkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

KN-----VKCSKTPVIVH---GISRNIDLGYQMFALNK-----KTTFVSVLKSLRSHCEGPVMQPIEYG
..      |  .|...||   ...|   .   . ..||         ..||||.|.   | |    .| 
eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq
DSPc_SM00195 449-702 4.1e-34 113.5 In-house 3-260 (263) alignment 
Range on Protein: 449-702
Range on HMM: 3-260/263.0
KEYVTKLLAKDSEKikSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLhkildkASTVFKFWWAVRQERV
||...||....|.|  ..  ..  |..|  . .. .... ||| |.   .. .||. .|| ||.. .  . |.|| ||       ||| .||. | .|.|
keefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......pstvedFWrmvweekv

THIVMLGQVNEEdanWNRMFCKYFPESADGIVKIGGFKISCCDMEEDE-DVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
. |||| . .|.    ..   .|.||...|  ..| ... . . |... ... ||| ...|. |....||.. ||.|   .||.. | .|.|.. || ||
kiivmlteeeen...gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

T----PVIVH---GISRN-----IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFM
     |..||   |..|      ||. .. .. .||  . ...|.||..  | | .  .| |..  |  
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 449-702 4.1e-34 113.5 In-house 3-260 (263) alignment 
Range on Protein: 449-702
Range on HMM: 3-260/263.0
KEYVTKLLAKDSEKikSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLhkildkASTVFKFWWAVRQERV
||...||....|.|  ..  ..  |..|  . .. .... ||| |.   .. .||. .|| ||.. .  . |.|| ||       ||| .||. | .|.|
keefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......pstvedFWrmvweekv

THIVMLGQVNEEdanWNRMFCKYFPESADGIVKIGGFKISCCDMEEDE-DVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
. |||| . .|.    ..   .|.||...|  ..| ... . . |... ... ||| ...|. |....||.. ||.|   .||.. | .|.|.. || ||
kiivmlteeeen...gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

T----PVIVH---GISRN-----IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFM
     |..||   |..|      ||. .. .. .||  . ...|.||..  | | .  .| |..  |  
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 451-655 6.1e-10 33.0 In-house 14-234 (302) alignment 
Range on Protein: 451-655
Range on HMM: 14-234/302.0
YVTKLLAKDSEKIKSVGMTDYVKKHSlEQREELPLVMATRVPLNVHgsrLTSDFFHANRIKCpNGLQLILTQSPLH------K-----ILDKASTVFKFW
.  . . .  ||.|    | . |. | |.|..| .     ..  |    . .||  || .|  .... |..| |.       |     |  | ||. |.|
efleyveraleklkkktstnlekdis.errkslficepktmaklvd...fkndfinanvlkl.deikwimaqGpmdGtekkekvskkpivpkkstlekhw

WAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADGIVKIGGFKISCCDMEEDED--VEERTLVV--------QYEKEKEFTVTHHLYKSWSMCSVPE
  . | .|. .| | .. |..   .. . .|. .  .| .| | . .   ....| .   . .....        . .|....||   .. .|     |.
alieqynvaivvqlcsfvede...ekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapk

NSKTLLKLIKNVKCSKTPVIVH---GISR
...| |...|  .. |. |.||   |. |
eaytaldilkfcesykknvlvhcsaGvGr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 454-653 2.8e-18 61.1 In-house 29-227 (305) alignment 
Range on Protein: 454-653
Range on HMM: 29-227/305.0
KLLAKDsEKIKSVGMTDYvKKHSlEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVM
|.|... |.   || ..  .|.. .. .|  |    |. |. . |   ||.  |. ..  ..  . |..|.||.      .||  ||  . .|.|..|||
kslyee.eesidvgkkea.nkak.nrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk......ntvadfWrliveekvstivm

LGQVNEEDANWNRMfckYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQY--EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC----SK-
| .. |.. .  |.   |.|||    ...| |..   . .. .|  || | .    |.... ||...   .|    ||. . .||.|||.|.     .| 
ltklveggkdkCrq...YWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

TPVIVH---GI
.|..||   |.
vpllVhCsagv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 464-704 8.2e-16 52.8 In-house 10-264 (270) alignment 
Range on Protein: 464-704
Range on HMM: 10-264/270.0
KSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN--GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDA
..  . ...... |   ...    |||| |.   .  .. .. || ..  .    . | ...||      ..|...||  . .|.|| |||. ...|.  
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPl......pttlksfwrmiweekvtaivmttgleEkgr

NwnrmFC-KYFPESADGIVKIGGFKISCCDMEED--EDVEERTLVVQyEKEKEFTVTHHLYKSWSMCSVPENSK------TLLKLIKNVK--CS---K-T
.     | .|.|....  ||.   ||. . ..|   |    . | .. || .|  ..|. |..|   .||...        |||....|.  ..   | .
k....kCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PVIVH---GISR-----NIDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
|..||   |. |      .| . ..   .||   ..... || .    | .| .| |.  .. .||
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 464-651 1.2e-11 39.3 In-house 37-219 (318) alignment 
Range on Protein: 464-651
Range on HMM: 37-219/318.0
KSVGMTDYVKKHSLEQREELPLvMATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDan
 |.  .. | |.       |.    ||| |.   .  .||.  || |   .   . | .|.||      . |.  ||  | .   . |||| |..|.   
tslkslepvnkaknryanilay.dhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPl......petieDfWrmvWeqnsavivmltqeeerg..

wNRMFCKYFPESadGIVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKE-FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK-----TPVIVH
  .   .|.|..  |  ..|  ..   .  | .|   |.. |. ..|.|  .|  . | ||.  .|||.. .||.|...|.  .     .|..||
.kakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 464-562 7.7e-07 23.0 In-house 42-134 (310) alignment 
Range on Protein: 464-562
Range on HMM: 42-134/310.0
KSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLtSDFFHANRIKCpNGL--QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDA
 |. .  | |.   ..  ..    ..|| |..  ||   |. ||| .|  | |   .| .| || .      |.  ||  . |||   |..| .| ||  
ssltyeaykkymhknrysdvvcldtsrvklkidksry.edyihanyvkt.nylrstficsqgplqh......tiidfwrmifqeraesilllckvgeegr

N
 
p
0040438 (Phosphotyrosine protein) phosphatases II 465-735 4.1e-43 143.3 In-house 34-307 (317) alignment 
Range on Protein: 465-735
Range on HMM: 34-307/317.0
SVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEedaNW
.  .. ... ... .    ..  ..|| |.. |..| ||. .|. ...|| . . |.||.||       .||..||. | ...||.|||| .  |   ..
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl......pntvedFwrmvweqgvtvivmLtelee...lg

NRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS----KTPVIVH---GISR
......|.|.  .. ...|.|.. ....||..... ||| |.. ......||||. |..|   .||.. ..||.... |. .    ..||.||   |..|
rekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgR

N-----IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAYDPTAVPDDITKIMNYLTEAFTTWFKID
      ..| ....  ... .. ...| ||... | |  |  | | .. ...|    .  . ... ..|....|.. . ...|..
tGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 467-660 9.4e-13 42.8 In-house 36-222 (288) alignment 
Range on Protein: 467-660
Range on HMM: 36-222/288.0
GMTDYVKKHSLEQREELPLVMATRVPLNvhgsrLTSDFFHANRIKC--PNGLQLILTQSPLhKildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANWN
 .. .... . .. |.||   .||| |.       .||. | ..    ..  .|| .|.|| .     .|. ..|  . .. | .|||| .. |   .  
iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPl.n.....gtieelWkmllesdveyivmlcellekGkeks

rmfCKYFPESADGIVKIGGFkisCCDMEEDEDVEERTLVV---QYEKEKEFT--VTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVH---GISRN
    .|||      ..|| .   | .. .. .  .....|   . .|| | .  | .  .. |   .|||| .. |.|.. .|  . |..||   |. | 
...aeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrt

IDLG
  | 
gtli
0036941 (Phosphotyrosine protein) phosphatases II 469-704 1.5e-40 134.7 In-house 34-277 (297) alignment 
Range on Protein: 469-704
Range on HMM: 34-277/297.0
TDYVKKHSLEQREELPLVMATRVPLnvhgSRLTSDFFHANRIKCPN-GLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMF
. ...  .. .    .    ||| |    .   ||...|. ..... . . |.|| ||.      .|| .||. | ...||.|||| .. |   ..  ..
allpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlp......ntvedFWrmvweqnvtvIvmltelve...lgrekc

CKYFPESADGIVKIGGFKISCCDMEE--DEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISR
..|.|.  .. .. |.|.. . ..|.  ..|.  ||| |.. ......||||. |..|   .|||. ..||..|. |.       |..||.||   |..|
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

N-----IDLGYQMFA---LNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
      .|| .|..     ... ......|.||... | | ..  | | .. .... 
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 469-655 3.7e-21 70.2 In-house 46-227 (301) alignment 
Range on Protein: 469-655
Range on HMM: 46-227/301.0
TDYVKKHSlEQREELPLVMATRVPLNVHGSRLTsdfFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMF
  |..|.  ......|    | | . |.| |.     ||| |. . .  ..| ||.||.      .|   ||  . |  | .||||||  |   ..... 
yaylpkdk.hryptvPckPstavevivdGkrvP...ihanwiptsGhphrfiatqgPlk......ntsedfwamlvqydvekivmlgqkve...kleekc

CKYFPESADGIVKIGGFKISCCDMEE--DEDVEERTLVVQYEKE--KEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVH---GISR
 .|.| .    ..|| |||   ..|   .... .||| |.   .  .  ||||. |..|.   ||.    | .|.. || |. |..||   || |
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 469-652 4.6e-09 30.7 In-house 30-210 (285) alignment 
Range on Protein: 469-652
Range on HMM: 30-210/285.0
TDYVKKHSLEQREELPLVMATRVPLNVHGsrltSDFFHANRIKCPNGLQ--LILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrM
| |  .  |..  ..  .  ||| |. |      |. ||. .. |   |   | || || .      |.  ||  . ||......||  . |   .    
tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpe......tlsdfwhmiyqekiayvlmlctlfeggve...k

FCKYFPESADGIVKIGGFKISCCDMEEDED---VEERTLVVQYE-KEKEFT-VTHHLYKSWSMCSVPENSKTLLKL---IKNVKCSKTPVIVHG
 . |.||    .||.| ..|.  . .|.     . .   |.. |    |   . |     |     ||... ...|   .|.|.  ..|. || 
calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhc
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 470-598 1.8e-07 24.9 In-house 47-165 (302) alignment 
Range on Protein: 470-598
Range on HMM: 47-165/302.0
DYVKKHSLEQREELPLVMATRVPLNvhgsRLTSDFFHANRIKCP-NGLQLILTQSPLHkilDKASTVFKFWWAVRQERVTHIVMLgqVNEEDANWnrMFC
 . |. .  | |..|.. ...| |.        .. .| ... |  . ..||.| |     | .. | .|| .| ||.....|.|  | ||. .    . 
afkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkv...dsedsveeFWrmvfqekivsvvil..vgeeelkk..tls

KYFPESADGIVKIGGFKISCCDMEEDEDVE
..||. ..  .. | . .     |. |. .
elfpkksgdykeygkmfvNnrkVekaeeek
0047943 (Phosphotyrosine protein) phosphatases II 473-703 2.6e-35 117.6 In-house 37-271 (273) alignment 
Range on Protein: 473-703
Range on HMM: 37-271/273.0
KKHSLEQREELPLVMATRVPLnvhgSRLTSDFFHANRIKCPN-GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYF
. ... .   .. .  .|| |    .  .||. .|. ....| . . |.|| ||       .|| .||. | ...|..|||| .. |   .... ...|.
enkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPl......pntvedfwrmvweqnvrviVmLtelve...lgrekcaqYw

PESADG-IVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISRN----
|.. ..  .. | |.. . ..|...|.  ||| ... . ....||||..|..|   .||.. . ||..|. |.       |..||.||   |..|     
pleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

-IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
 .|| ....  ... .. ...| |||.  | |. |  | | .. ...|
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0050432 (Phosphotyrosine protein) phosphatases II 474-704 2.4e-36 121.1 In-house 68-299 (308) alignment 
Range on Protein: 474-704
Range on HMM: 68-299/308.0
KHSLEQREELPLVMATRVPLnvhgsRLTSDFFHANRIKCP---NGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKY
 ... .    .    .|| |       .||. .|. ....   .  . |.||.||       .|| .||. | ...|..|||| .  |   |    ...|
nkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPl......pntvedFwrmvweqnvrvIvmLtklve...ngrekcaqY

FPESAD-GIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS--KTPVIVH---GISR-----NID
.|.. . |....|.|.. . ..|...|.  ||| ... ......||||  |..|   .||.. . ||.... |. |  . |..||   |..|      .|
wplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfiald

LGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
| ....  ... .. ...| ||..  | |  |  | | .. ...|.
llleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0042113 (Phosphotyrosine protein) phosphatases II 474-702 3.7e-32 107.1 In-house 9-241 (245) alignment 
Range on Protein: 474-702
Range on HMM: 9-241/245.0
KHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFP
 ... . .. ..   ||| |...|..| ||. .|. .....   ..|.|| ||..      || .||. ......|.|||| .  |   ..   ...|.|
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe......tvedfwrmlwelgittivmLteeee...lgrvkcaqywp

EsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC-----SKTPVIVH---GISR-----NID
.  ......|.|.. . ..| ..|.  ||| |..  . ....|.|..| .|   .||.....||.... |.      |..||.||   |..|      ..
l..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

LGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFM
| ....  ... .. ...| |||.. | |. |  | | .. ...
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 474-703 8.4e-31 102.9 In-house 11-245 (249) alignment 
Range on Protein: 474-703
Range on HMM: 11-245/249.0
KHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanWNRMFCKYFP
 ... .    .    .|| |.. ...  ||. .|. |.... . ..|.|| ||..      || .||. ......|.|||| .  |    ..  ...|.|
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe......tvedfwrmlwelgitvivmLtslvel...grekcaqywp

EsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISR-----NI
.  .| ...|.|.. . ..|. .|.  ||| ... .. ...||.|  | .|   .||.. ..||..|. |.       ...||.||   |..|      .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
.| ....  ... .. ...| |||.. | |. |  | | .. ....
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0051299 (Phosphotyrosine protein) phosphatases II 477-704 2e-36 121.3 In-house 52-286 (288) alignment 
Range on Protein: 477-704
Range on HMM: 52-286/288.0
LEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKC-PNGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPEsa
  .   ..    .|| |.| ..  .||. .|. |.. ... . |.|| ||.      .|| .||. | ...|..|||| .. |   . .. ...|.|.  
knRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp......ntvedFWrmvweqnvrvIvmltklve...lgrekcaqYwpl..

DGIVKIGGFKISCCDMEEDEDVEERTLVVQY-----EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS----KTPVIVH---GISR-----NID
.| ...| ... . ..|...|.  ||| |..      .....||||. |..|   .||.. . ||.... |. .    . ||.||   |..|      .|
ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfiald

LGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
| ....  ... .. ...| ||..  | |  |  | | .. ...|.
llleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 477-703 2.5e-34 114.4 In-house 48-276 (278) alignment 
Range on Protein: 477-703
Range on HMM: 48-276/278.0
LEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPesa
. .    ..   .|| |.. |..| ||. .|. ....| . . |.|| ||..      || .||. |....||.|||| .  |   ...  ...|.|   
knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......tvedFwrmvwelgvttivmLtelve...lgrvkcaqYwp...

DGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC----SKTPVIVH---GISRN-----IDLGYQ
.| ...|.|.. . ..|...|.  ||| | .  . ...||||. |..|   .|||. ..||...| |.     |..||.||   |..|      ..| ..
ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllle

MFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
..  ... .. ...| ||... | |. |  | | .. ...|
qlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPRB_pd Subfamily PTPRB 477-651 7.8e-18 59.5 In-house 54-224 (293) alignment 
Range on Protein: 477-651
Range on HMM: 54-224/293.0
LEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPES
 .. ...    ..|| |.   .. .||.  || |.  |   . | || ||..      || .||  | ..... |||| |. |.     .. | .|.|. 
knrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe......tvddfWrmvwekkssiivmltqlvekg....kvkCeeYWPad

ADGIvKIGGFKISCCDMEEDEDVEERTLVVQYeKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVK------CSKTPVIVH
 . .   |  |..    || ||   |.| ..  ...| .|... ..||.   |||..||||.....|.      .||.|..||
eepv.lyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 478-651 8.4e-14 46.3 In-house 49-222 (319) alignment 
Range on Protein: 478-651
Range on HMM: 49-222/319.0
EQREELPLVMA---TRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRMFCKYFPE
...   . ..|   ||| |        ||.  |. |   .   . | ||.||..      |.  ||  | .|..  .||| ...|.     ....| ...
kkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen......tiedfWrmvWeeessivvmltklvek....lkvklkkywp

SADgIVKIGGFKISCCDMEEDEDVEERTLVVQYeKEKEF---TVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK-----TPVIVH
... ... | . .   . || ||.. | | ..  |  |    .|.|. |..|.   |||....||.|.|... |.      |..||
een.feeyGrlivtleeeeeledyiirklklnk.kssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvh
0046845 (Phosphotyrosine protein) phosphatases II 479-704 5.1e-36 119.9 In-house 33-274 (284) alignment 
Range on Protein: 479-704
Range on HMM: 33-274/284.0
QREELPLVMATRVPLNVHGSR-LTSDFFHANRIKCP------NGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYF
.   ..    .|| |.. ...  .||...|. ....      .  . |.|| || .      || .||. | ...|..|||| .  |   | . ....|.
RykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn......tvedFwrmvweqnvrvIVmltelve...ngrekcaqYw

PESaDGIVKIGGFKISCCDMEEDEDVEERTLVVQYE--KEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS------KTPVIVH---GISR-----
|.. .. ...|.|.. . ..|...|.  ||| ....  .....||||. |.||   .||.... ||.... |. .      . |..||   |..|     
ple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

NIDLGYQMFALNK---KTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
 .|| ....  ..   . .. ...| ||..  | | ..  | | .. ...|.
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_PTPN13_pd Subfamily PTPN13 479-654 3.3e-13 44.6 In-house 43-214 (273) alignment 
Range on Protein: 479-654
Range on HMM: 43-214/273.0
QREELPlVMATRVPLNVHGSrltsdFFHANRIKCP---NGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPES
 |. || . .|||.|. .|.     .  |. || |   .  . |..| || .      ||  ||  | . ... |.|. .  |..    .. | .|.|||
yrnvlP.ydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPe......tvkdfwqmvweqkaeviamvtlekekg....kvkchrywPes

ADGIVKIGG-FKISCCDMEEDEDVEERTLVVQYEKE-KEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK---TPVIVH---GIS
..  .|. . ....  .... ..   |.| |.  .  .   |.|  . .|   .|| ... ||.....|.  .   .|..||   || 
knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiG
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 480-651 1.1e-19 65.5 In-house 51-216 (315) alignment 
Range on Protein: 480-651
Range on HMM: 51-216/315.0
REELPLVmATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRM-FCKYFPESADG
.. |||   .|| |.|      ||.. |  ||  .     | .| ||.      ..|  ||  | ||.|| |||. . .|.|    ..   .|.|.    
knilPld.sarvkleviddsPdsdyinasyiksvdddkayiasqgPlk......asvddfwrmvlqekvttivmvtkkqegd....kikcrqywPdrkad

IVKIGGFKISCCDMEEDEDVEERTLvVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT----PVIVH
 |. | .|..  ..| | |   | | |  . |.  ||| . .. |    |.... .||||||.||...     ...||
svefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh
subfamily_PTPN6_pd Subfamily PTPN6 480-644 1.9e-14 48.4 In-house 61-218 (306) alignment 
Range on Protein: 480-644
Range on HMM: 61-218/306.0
REELPLvMATRVPLNvHGSRLTSDFFHANRIK--CPN-GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESAD
.  ||    ||| |. . |   ||.  || ||   ..   . | ||  |       .||  ||  | ||  . |||. . .|   .   . ..|.|.. .
knilPf.Dhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl......ettvsdFWrmvwqensrvivmttkevErgke...kCarYWPdeee

GIVkIGGFKISCCDMEEDEDVEERTLVVQ--YEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS
     |  ...... .. .| . |.|.|.   .|..| .| .. .|||   .||.. ...|.....|.  
kee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 480-652 1.4e-11 39.0 In-house 47-216 (307) alignment 
Range on Protein: 480-652
Range on HMM: 47-216/307.0
REELPLVMATRVPLNVHGsrLTSDFFHANRIKC-PNGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRMFCK-YFPEsADG
 .... .  .|. ....|  |.||. ||| .    .  ..| .| ||.      .|...||  . ||.|  ..|| .| |      .. |. |.|   .|
yqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgple......ntqysfwamaiqekvesvimlckviel....akikceqywpl.eeg

IVK---IGGFKI-----SCCDMEEDEDVEER-TLVVQYEkEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHG
  .     .  |      .  .  |||. .  || |..  .|  |..|  .. |    ||.   | . |.. |.  . ||.|| 
qklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhc
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 480-651 2.1e-10 34.6 In-house 52-175 (392) alignment 
Range on Protein: 480-651
Range on HMM: 52-175/392.0
REELPLVmATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwnrmfckyfpesadgi
.. ||.  ..|| |.|      ||.. |  |..  |    | .|.|       |...  ||  | ||.|| |.|. ...| |                  
knilpyd.sarvkleviddipdsdylnasyipsfdnekayiasqgpn......aaslddfwrmvfqenvttiamvtklkegd..................

vkiggfkisccdmeededveertlvvqyEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK---T-PVIVH
                              ..  ||. . .  |    ||. . .|||.||.||.     | |.|.|
............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliih
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 481-653 5.7e-20 66.1 In-house 44-208 (281) alignment 
Range on Protein: 481-653
Range on HMM: 44-208/281.0
EELPLVMATRVPLNV-HGSRLTSDFFHANRIKCPNG-LQLILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRM-FCKYFPESADG
 ..| .  .|| |.|    . ..|. ||| |. |      |||| |      |  |   ||  . ||  | |||| |. |     ||   ..|||  |  
lnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgp......kketradfwrmiwqenttaivmlcqflet....nrekcaeyfprnahc

IVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKEFtVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHGI
 ...  . .|  |   .. .    | . || |  . .|| |.| |    ||| |. .||.......  || ..|  
clqfdklsvsyedstvnkslvttrlnlsyegetrl.ithwlwkewpdwqvpessevmlkilrkirarstppvihcs
subfamily_PTPRN_pd Subfamily PTPRN 481-653 3.7e-10 34.0 In-house 64-232 (297) alignment 
Range on Protein: 481-653
Range on HMM: 64-232/297.0
EELPLvMATRVPLNVHGSRLTSDFFHANRIK--CPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGI
. ||    .|| |. . |. .||.  |  |    |     | ||.||      |||| .||  | .. |. ||.| ...||. .      .|.|.    .
avlpy.dhsrvklkeeasaeksdyinasaildhdprapayiatqgpl......astvadfwqmvweqGvvvivnltrleeegvk...qckrywpdeGsev

VKIGGFKISCCDMEEDeDVEERTLVV-QYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVK----CSKTPVIVHGI
 .|   ..    .  | |   |.. . . ....  |||   . ||   .|| ..|.||.. . |        .|..||. 
yhiyevhlvsehiwcd.dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcs
subfamily_PTPN14_pd Subfamily PTPN14 481-643 2.3e-09 31.6 In-house 57-214 (300) alignment 
Range on Protein: 481-643
Range on HMM: 57-214/300.0
EELPLvMATRVPLNVHGSRlTSDFFHANRIKCPNG---LQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPES--A
. ||    .|| |.      ....  | .|| . |   .. | .|.||..      || .||  | .. |. |||| . .|.    .    ||||..   
dvlPy.ednrvelsptken.stgyinassikvsvggkersyivaqgPlel......tvqdfWqmvWeqgvqlivmlteeeedg...keksfkyfPklesk

DGIVKIGGFKISCCDMEEDEDVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC
   |. | ||..    |. . |  ..| ...   ..| || |  |. |.   |||. |. |. ...|. 
kktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs
subfamily_ptpA1_pd Subfamily ptpA1 481-659 5.3e-08 27.0 In-house 54-232 (418) alignment 
Range on Protein: 481-659
Range on HMM: 54-232/418.0
EELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEE-----DANWNR-MFCKYFPES
 ..  |  ||| |.    .  ||.  || |      |.| || ||        |.  ||  | ..|.  |||| . .|.     |  |   .  . |   
tnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgpl......pntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiy

ADGIVKIGGFKISCCDMEEDEDVEE--RTLVVQYEKEKEfTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPvIVHGISRNIDL
 .|   .| . .   .. .| . |   | . . .| |    .|.. |. |    .|. .. . .|....   .   |.    ||. .
gngnevfgtysvelveviqdpereiitrnirltfegetr.ditqyqyegwpdhnipdhtqpfrqllhsitnrqnq.iipssdrnvpi
0039614 (Phosphotyrosine protein) phosphatases II 482-703 2.9e-34 114.3 In-house 64-288 (297) alignment 
Range on Protein: 482-703
Range on HMM: 64-288/297.0
ELPLVMATRVPLNVHGSR-LTSDFFHANRIKCPN--GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNrMFCKYFPESADgi
. .    .|| |.. ... | ||. .|. .....  . . |.|| ||..      || .||. |....||.|||| . .|   ... ....|.||. .  
dilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe......tvedFwrmvweqgvtvivmLtklve...lgr.kcaqywpeegg..

vKIGGFKISCCDMEEDEDVEERTLVVQYeKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISRN-----IDLGYQMF
 . |.|.. . . |.....  ||| |.. .....||||..| .|   .||.....||.... |.       ...||.||   |..|      ..| ....
.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql

ALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
  ... .. ...| ||... | |. |  | | .. ....
ekeggvdvleavkelreqRpgavqtpsqyrflydallel
subfamily_Ptp69D_pd Subfamily Ptp69D 482-652 1.4e-17 58.8 In-house 56-226 (307) alignment 
Range on Protein: 482-652
Range on HMM: 56-226/307.0
ELPLVMATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedanWNR-MFCKYFPESadGIV
..     ||| |..   . .||.  |. ||   .  . |  | |.       .|.. ||  . .  || |||| ...|    .||    ||.|.    .|
dikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve......atigDfWRmiaeqevtlivmlsnlte....knrkkcakYWpie..dev

KIGGFKISCCDMEEDEDVEERTLVVQYEK------EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNV----KCSKTPVIVHG
. |   . . . |. .|  .|.| |   |      |..  |. . |..|    ||| ...|||||..|    | ...|..|| 
qygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhC
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 483-651 5.7e-20 65.9 In-house 53-215 (515) alignment 
Range on Protein: 483-651
Range on HMM: 53-215/515.0
LPLvMATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKI
||.   .|| |.|      ||.| |  |.  .     | .| |..      ..|  ||  | ||.|| |.|. . .|.|        ||.|.     || 
lPy.dsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnk......asvddfWrlvlqenvttiamvtklkegdki...kcgkyWPdkpgdsvkf

GGFKISCCDMEEDEDVEERTLVVQYEKEkEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT----PVIVH
| .|..   .| . .   |.| |  ...   ||| . .. |    ||.....||||||.||...     |.|.|
Gsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliih
Y_phosphatase Protein-tyrosine phosphatase 484-697 1.6e-30 101.6 Pfam-A 11-230 (235) alignment 
Range on Protein: 484-697
Range on HMM: 11-230/235.0
PLVMATRVPLnvHGSRLTSDFFHANRIK-CPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESADGIVKIG
.    ||| |  .||  .||. .|| .|  ..  ..|.|| ||       ||. .||. | ||.|. |||| ...|..    . . .|.||. .. .. |
lpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPl......kstiedFWrmvwqekvkvivmltsleekgr...ekcaqYwpeeeeesltyg

GFKISCC-DME-EDEDVEERTLVVQYEKEKE--FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVH---GISRN-----IDLGYQMFAL
 .|. .  . . .....  |.| .. .||..  ..|... |..|   .|||..| ||.||..|. ||    .||.||   |..|      .|.  ...  
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

NKKTTFVSVLKSLRSHCEGPVMQPIEYGFAI
....  ....|.||..  | | .  .| | .
eeevdvlqivkelRkqRpgmvqsleqYifly
Y_phosphatase Protein-tyrosine phosphatase 484-697 1.6e-30 101.6 In-house 11-230 (235) alignment 
Range on Protein: 484-697
Range on HMM: 11-230/235.0
PLVMATRVPLnvHGSRLTSDFFHANRIK-CPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESADGIVKIG
.    ||| |  .||  .||. .|| .|  ..  ..|.|| ||       ||. .||. | ||.|. |||| ...|..    . . .|.||. .. .. |
lpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPl......kstiedFWrmvwqekvkvivmltsleekgr...ekcaqYwpeeeeesltyg

GFKISCC-DME-EDEDVEERTLVVQYEKEKE--FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVH---GISRN-----IDLGYQMFAL
 .|. .  . . .....  |.| .. .||..  ..|... |..|   .|||..| ||.||..|. ||    .||.||   |..|      .|.  ...  
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

NKKTTFVSVLKSLRSHCEGPVMQPIEYGFAI
....  ....|.||..  | | .  .| | .
eeevdvlqivkelRkqRpgmvqsleqYifly
subfamily_PTPN9_pd Subfamily PTPN9 484-645 1.1e-15 52.4 In-house 52-206 (297) alignment 
Range on Protein: 484-645
Range on HMM: 52-206/297.0
PLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPESADGIVKI
  .  ||| |.      .||. .|| .   .    .| || ||.|      ||  ||  | ...|  |||  .| |.     |. | .|.|.. .   . 
lcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk......tvsdfWrmvWeqevlvivmttrvverg....rlkcgqyWpleeessaef

GGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
| ...|  ..|| || ..|.|...  ..|.. .|||. . ||    ||.....||.....|.  .
gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq
subfamily_egg_pd Subfamily egg 484-653 3.1e-14 47.4 In-house 50-209 (307) alignment 
Range on Protein: 484-653
Range on HMM: 50-209/307.0
PLVMATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanwnrMFCK-YFPESADGIVKI
.    .|| |...  . . || ||||.|      ..||.|.||        ||  ||  | ||.| .||||    |         |. |.| . .  ...
hckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkn......tvddfwrmvfqeevqyivmltsrkes......erceyywpkaesdslvt

--GGFKISCCDMEEDEDVEER--TLVVQYEKEKEFTVtHHLYKSWSMCSvpeNSKTLLKLIKNVKCSKTPVIVHGI
  |...| . ....  |   |   | .   ...|  .  |    .   |   .  . |.... ..   .||.|. |
vpGslrienlkvdskadplfrvtklklvGgddeerfl.ehwqgdvnnss...dvysplrvlrklrnlskpvvvqdi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 487-651 4.3e-14 47.3 In-house 64-223 (297) alignment 
Range on Protein: 487-651
Range on HMM: 64-223/297.0
MATRVPLNVHGSRLTSDFFHANRIKCPNGlQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnrMFCKYFPESadGIVKIGGFKI
   || |.. ..   ||.. |  .|  .  .|| || | .      .||  ||  | .|.|. |||| . ||.|        .|....  |... |   .
dssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmk......atvadfWamvldeqvstivmlnddnerdk....kcaryWsdk..gvttfGdvsv

SCCDMEEDEDVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPE--NSKTLLKLIKNVKCS-----KTPVIVH
    ..| |   .|.|.|. .|  ..  |  . . .|   .|..  . ..|||||..|. .     ..|..||
vllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh
subfamily_CG42327_pd Subfamily CG42327 487-644 2e-06 21.7 In-house 41-193 (319) alignment 
Range on Protein: 487-644
Range on HMM: 41-193/319.0
MATRVPLNVHGSRLTSDFFHANRIKCPNGLQL--ILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESA--DGIVKIG
  ||| |.  |.   . ...|. .. ..  .   | .| .|       ..  .||  | . .   || | .. |      ..  .|.| ..  |.    |
PetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsl......edsssdfwrtvweqqsrvivqltdlselGi...kvcaeylPtketldntslyG

GFKISCCDMEEDEDVEERTLVVQ-YEKEKEFTVTHHLYkSWSMCSVPENSKTLLKLIKNVKCS
 ....  . | ..     ||...  .||.   .||. |  |  . || . ..|. .. .|. |
dilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0045098 (Phosphotyrosine protein) phosphatases II 488-655 2.4e-25 84.9 In-house 47-219 (278) alignment 
Range on Protein: 488-655
Range on HMM: 47-219/278.0
ATRVPlnvhgsrltsDFFHANRIKCPnGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsaDGIVKIGGFKIS
 .||           |. .|. |... . . |.|| ||       ||| .||  ......|.|||| .. | . .    ...|.||  .| . .|.|.. 
hsrVk..........dYINAsyidgy.pkkfIatqgPlp......stvadfwrmlwelgitvivmltelvelgre...kcaqywpe..ggsltygdftvt

CCDMEEDEDVEERTLVVQY-----EKEKEFTVTHHLYKSWSMCSVPENS--KTLLKLIKNVKC-----------------SKTPVIVH---GISR
. ..|. .|.  ||| |..     |  ....|||. |..|   .||...  | .|.|.. ..                  |..||.||   |..|
llseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 488-646 9.1e-19 62.6 In-house 42-195 (274) alignment 
Range on Protein: 488-646
Range on HMM: 42-195/274.0
ATRVPLNVHGSRLT-SDFFHANRIKCPNGLQ--LILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRM-FCKYFPESADG--IVKI
 .|| |. . |.   |..  || || ... .   . || ||      ..||. ||  . ||.|. |||| ...|.    |.    .|||.. |     . 
nsrvllesessededssyinanyikGydeeskayvatqGPl......pntvadfWrmiyqeevqvivmltklkea....neqkCavyfPdaedyeisery

GGFKISCCDMEEDEDVEERTLVVQYEKEkEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT
|...|   .. | .| . |.||..| .. | .|.|..| .|    .|.. .|||.|...|. |..
gdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesre
subfamily_PTPN12_pd Subfamily PTPN12 488-651 7.3e-17 56.2 In-house 54-213 (290) alignment 
Range on Protein: 488-651
Range on HMM: 54-213/290.0
ATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPESADGIVKIGGFK
 .|| |. . .   ||.  || || ..| |. | .|.||      . |.  ||  . . .|. .||. .. | .    .. | .|.||. .  ...| |.
ksrvelskieeeegsdYinanfikgvegkleyiaaqgPL......pktlddfWrmiweknveivvmaCrevelg....kkkCerYWpeegeeelefgefe

ISCCDMEE-DEDVEERTLVVQYEKEKEfTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVH
... . .  |.|   ||| |. .||.  .|.   |..|    ||.. |.||.||..|.. .    .|..||
vtleeekavdddflirtLkveaqkesr.kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvh
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 488-651 3.8e-15 50.8 In-house 55-214 (281) alignment 
Range on Protein: 488-651
Range on HMM: 55-214/281.0
ATRVPLNVHGSRLTSDFFHANRIKC-PNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRMFC-KYFPESADgIVKIGGFK
|||| .. . .  ..|.  || ..   .  . | ||.|.       ... .||. | ...|. |||. .  |.    ... | .|.|. .   .|.| ..
atrvkvtpneenkntDYinanfvpgykgekeyiatqgPv......PaslvafWqmvweqkvsaivmvtreiea....gklkChrYWPddns.elkygdvt

ISCCDMEEDEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNV-KCS----KTPVIVH
..    || .   ||.. .. |. .. .|..  |..|    ||...| ||.  |.| |..    |.|...|
vkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvih
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 488-645 1e-08 29.7 In-house 62-211 (325) alignment 
Range on Protein: 488-645
Range on HMM: 62-211/325.0
ATRVPLNVHGSRLTSDFFHANRIKCPNGLQL-ILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrmFCKYFPESADGIVKIGGFKI
 .|| |.  .    ||.. |. ..   . .  . .|.||      ..|.  .|  | . | . .|.| ...... .     ..|.|.     .. ||...
ksrvvletkkddpssdyinasylrddkkkdvflaaqaPl......tatindlWrlvldWrcsvvvvlneldlgkdr....cavywpkemgksktfGglev

SCCDMEEDEDVEERTLVVQYEKEK-EFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
.   .||  |   | | |.  |.    .|    ..||    |..   ||. ... ||  .
klrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs
0037934 (Phosphotyrosine protein) phosphatases II 489-655 4.8e-22 74.1 In-house 25-191 (243) alignment 
Range on Protein: 489-655
Range on HMM: 25-191/243.0
TRVPLnvHGsrltSDFFHANRIKCPNglQLILTQSPLHKildkasTVFK----FWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPesaDGIvKIGGF
.|| |   |    ||...|| |....  .||.|| || .      ||.     ||  . ....|.|||| .  |   ..    ..|.|   ...  .|.|
srvkl..eg....sdyinanliyvtp..rliatqgPlpe......tveddlasfwrmlwelgitvivmltelvE...lgrekcaqywp...gev.tygdf

KISCCDMEEDEDVEERTLVVQY--EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVK------------CSKTPVIVH---GISR
.. . ..|. .|.  |||....  ... ...|.|..| .|   .||.. . ||.... |.             |. ||.||   |..|
tvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR
subfamily_PTPN23_pd Subfamily PTPN23 489-651 3.3e-17 57.2 In-house 58-218 (288) alignment 
Range on Protein: 489-651
Range on HMM: 58-218/288.0
TRVPLNvhgsRLTSDFFHANRIK--CPNGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANWNRmfcKYFPESADGIVKIGGFKI
.|| |.      . |.  |  .|   |   ..| ||.||.      ||.  ||  | ....  |||| . .| . . .    .|.||. .  || | ...
nRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlq......stlnDFWlmvyeqkssviVmllskeelgkpkvd...rYwPedkgetvkfgdlsv

SCCDMEEDEDVEERTLVVQYEKEKE-FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC--------SKTPVIVH
.. . .| | . ||.| .. .....  .|.|  ..||.   ||.  .|||.....|.         ||||..||
tlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvh
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 489-651 2e-16 54.9 In-house 24-181 (250) alignment 
Range on Protein: 489-651
Range on HMM: 24-181/250.0
TRVPLNVHGSRLTSDFFHANRIKCPNGLQ-LILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrmFCKYFPesADGIVKIGGFKIS
.|| |. . .   ||.  |  ..  .. .  | ||.||..      |. .||  | .| .. |||| ...|.. .    . .|.|  ...  | |. ..|
srvvLekekgdkesdyinasflhgyderkafiatqgPlqa......tiedfWrmvleeksgtivmLtnLkesekt....yhqywP..vekaekyGdvtvs

CCDMEEDEDVEERTLVVQYEKEK-EFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC-----SKTPVIVH
  . ||  |.. |.|..  .|.. | .| .  . .|   .|||. .. |.|.|.|.       ..||||.
llskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 489-651 3.6e-16 54.3 In-house 71-229 (298) alignment 
Range on Protein: 489-651
Range on HMM: 71-229/298.0
TRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESadGIVKIGGFKIS
.|| |. . .   ||.  |  ..  .|    |.|| ||..      ||  ||  | .| .. |||| ...| |      . ||.|..  |  . | ...|
sRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte......tvedFWrmvteedigtiVmltnleeldkt...kyhkywPde..gketygeitvs

CCDMEEDEDVEERTLVV-QYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC-----SKTPVIVH
    ||  |.. |.| | ....||| .| .  . ||.  .||||....|.|...|.       ..||||.
llskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivq
subfamily_PTPRD_pd Subfamily PTPRD 489-651 5.6e-16 53.3 In-house 63-220 (564) alignment 
Range on Protein: 489-651
Range on HMM: 63-220/564.0
TRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESaDgIVKIGGFKIS
.|| |.       ||.  |. |.  .   . | || ||      |.|.  ||  | ..... |||| ...|.. .    . ||.||. .   ..|.....
sRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl......aetiedFWRmvweqnsstiVmltkleEkgkv...kchkYWPek.g.tetygeltVt

CCDMEEDEDVEERTLVVQYEKEKE-FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS----KTPVIVH
  . || .|.| ||. .. .|..|  .|..  . ||    |||. ..||.||..|. .    . |..||
leeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVh
subfamily_PTPRG_pd Subfamily PTPRG 489-652 2.1e-10 34.4 In-house 62-227 (563) alignment 
Range on Protein: 489-652
Range on HMM: 62-227/563.0
TRVPLN-VHGSRLTSDFFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPEsaDGIVKIGGFKI
.|| |. . |   . |.  || |.    . . | || ||.      .|.  ||  . ...|. |||. ...|. .   |    |.|.  |. ...| ...
sRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk......dtfddFWrmiWeqnvaiivmitnlvergr...rkcdvYWPk..desetygalqv

SCCDMEEDEDVEERTLVVQY---EK----EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS-KT---PVIVHG
   . |      .||||..    .|    ..| .|... | .|  ..||| |   |. .|  . . |.   |..|| 
tlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 489-642 2.4e-10 35.0 In-house 18-163 (237) alignment 
Range on Protein: 489-642
Range on HMM: 18-163/237.0
TRVPLNVHGSRltSDFFHANRIKCPNGL--QLILTQSPLHKILDkastvfKFWWAVRQERVTHIVMLGQVNEEdanwNRMFC-KYFPeSADGIVKIGGFK
.|| |.  ||   ||.  |. .|  .|   . | .| ||    |       ||  | ||. . ||||  . |     |.. | ||.| |.|     | . 
srvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscd......dfwqmvwqekcsvivmltglieg....nelkchkywp.stdqpaaygvlt

ISCCDMEEDEDVEERTLVVQYEK-EKEFTVTH-HLYKSWSMCSVPENSKTLLKLIKNVK
.| .  ||  |   |.|.....   ||  . | . . ||    ||... .||.. ||. 
vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrknii
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 489-641 4.5e-09 30.5 In-house 53-197 (287) alignment 
Range on Protein: 489-641
Range on HMM: 53-197/287.0
TRVpLNVHGSRLTSDFFHANRIKC-PNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEdANwNRmFCKYFPESaDGIVKIGGFKIS
||| | .. ..| ||.  || .    .  . | .|.|.      |.|| .|| || ..|.. .... .  || |  ..   ||.||  .  ...||. . 
trv.llsaegelGsdyinanyvasytddeafiaaqgPi......aatvrdfwravletrsasvitmtrevee.ar.lk.cykywPer.evPmrvGGysvv

CCDMEED-EDVEERTLVVQYEKEKEFTVTHHL-YKSWSMCSVPENSKTLLKLIKNV
  | .    .   |.| .   . .|  | . | . ||   ...  .  |.... .|
lldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldv
subfamily_PTPRA_pd Subfamily PTPRA 490-645 3.2e-11 37.7 In-house 74-224 (330) alignment 
Range on Protein: 490-645
Range on HMM: 74-224/330.0
RVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsaDGIVKIGGFKISC
|| |.|     .||.  |  |.  .   . | .| |      |. ||  ||  . . . . |||| ...| . .      .|.|.  .|.|  |  ... 
rvilsvkeGveesdyinasfidGykekdkfiaaqGP......keetvedfwrmiweqksativmltelkerkee...kcaqywPd..eGlvtyGnirvev

CDMEEDEDVEERTLVVQ-----YEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
 |... .|.  | ..||      ...|.  |.   ..||    || ... .|||.|.||  .
edetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 490-646 7.7e-11 36.5 In-house 65-209 (315) alignment 
Range on Protein: 490-646
Range on HMM: 65-209/315.0
RVPLNVHGSRLTSDFFHANRIKCPNGLQ-LILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESadgIVKIGGFKISC
|| | .      ||.  || |.  |  .  | .|.|.      ...|  ||  | .| ...|||| .. |..   .|.  ||.|.     |  | . .. 
rvqlpllendphsdyvnanfidGynkkrryiaaqgpn......vasvkdfwrlvfeedigkivmltnlvege...krkaekywpdk...kviyGkitvtr

CDMEEDEDVEERTLVVQYEKeKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT
 . |  ...  ||| | ... .  .|    | ||    ||. . .|..||..||  .|
kseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqhht
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 495-643 5e-09 30.4 In-house 52-196 (297) alignment 
Range on Protein: 495-643
Range on HMM: 52-196/297.0
VHGSRLTSDFFHANRIKCPN---GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDM
. ..   .|.  |. .  |.    |. ||.| ||..      ||  ||  | .. |  |||. ...|.  .       |.|.. ..  | | . .     
llrviterdyinadyvvfpdeeadlkyilaqGplsa......tvddfwtlvaeqdvrvivmvaklqedGrd...kcapywpsvvqerlkagdvvveflss

EEDE--DVEErTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNV-KC
  ||   |   | .  . ....  |.|  . ||    || . . | ..  .|  |
tsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_PTPRK_pd Subfamily PTPRK 496-650 1.6e-16 55.1 In-house 65-215 (314) alignment 
Range on Protein: 496-650
Range on HMM: 65-215/314.0
HGSRLTSDFFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVnEEDANWNrmFCKYFPESADGivkIGGFKISCCDMEED
      ||.  |. |    .  . | || ||.      .||  ||  | .|. . |||| ..  | ....   .||.|| ..     | .|. . ..| .
idgdpssdyinaalidsykrpaafivtqgPlq......etvkdfWrlvydencasivmltel.vevgrvk..ClkyWPedtev...ygdikvelvetell

EDVEERTLVVQY---EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTP----VIV
...  |.. |.     .|.  .| .  . .|..  || . ..||||...|| |. .    ..|
aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivv
subfamily_PTPN1_pd Subfamily PTPN1 500-645 1.7e-11 38.4 In-house 54-195 (290) alignment 
Range on Protein: 500-645
Range on HMM: 54-195/290.0
LTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESAD-GIVKIG--GFKISCCDMEEDE
   |.  |. .. ..   . |||| || .      ||  ||  | ...   .||| .| |.. .      .|.|.  .   ...    .|.     |. .
adndyinaslveleeakrsyiltqGPlpn......tvdhfWqmvWeqkskavvmlnkvvekeqi...kcaqywPqgeeekellledtklkvkliseerks

DVEERTLVVQYEKEK-EFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
    |.| ..  | .   ...|. | .|.  .|||   ..||.. .|. | 
yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresG
0046846 (Phosphotyrosine protein) phosphatases II 500-652 3.7e-06 22.3 In-house 10-116 (176) alignment 
Range on Protein: 500-652
Range on HMM: 10-116/176.0
LTSDFFHANRIKCPnglqliltqSPLHKILDKASTVFKFWWAVRQERVTHIVMLGQVNEEDANWNRMFCKYFPESADgivkiggfkisccdmeededvee
| .|. .|| | ..          |. .  .  .|. .|.  ......|..|.| .  | .  .   ..... .                          
ldldyinanlilgs.........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

rtlvvqyekekeftvtHHLYKSWSMCSVPENsKTLLKLIKNV---KCSKTPVIVHG
                ..|.  |   .||.  . ||.|.. .     .. ||.|| 
................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHC
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 501-655 1.2e-15 51.9 In-house 79-234 (305) alignment 
Range on Protein: 501-655
Range on HMM: 79-234/305.0
TSDFFHANRIKCPN--GLQLILTQSPLHKILDkastvfKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADGIVKI-GGF---KIS-CCDMEE
 ||. ||| . ||     ..| .| || . .|      .||| | |..| .|||| .  |     .   ..|.| .    ... .|    ..| .  || 
psdyihanyvgcpmipekrficaqgpldqtid......efwwmviqnkveqivmlcktvelg...klkcaqywpaaqgeklelksgivvenvsgskpmer

DEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHG---ISR
| ...  .| . |  .....| |  .  |    ||    | |.|.  .. || |..||    | |
daeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigr
0041856 (Phosphotyrosine protein) phosphatases II 502-652 2.8e-10 35.6 In-house 19-119 (182) alignment 
Range on Protein: 502-652
Range on HMM: 19-119/182.0
SDFFHANRIKCPNGL-QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGqvneedanwnrmFCKYFPesadgivkiggfkisccdmeededveer
.|. .|| . ..    . |.|| || .      || .|.  ......|.||.|              . |.|                            
ldyInanlylgslpatrfiatqgplls......tvadflrmlkelgittivnlt............eelywp............................

tlvvqyeKEKEFTVTHHLYKSWSMCSVPEnSKTLLKLIKNVKCSKTPVIVH---G
       .. | .....|| .|   .||.   .||..|. |. .. ||.||   |
.......ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaG
0051429 (Phosphotyrosine protein) phosphatases II 502-651 1.2e-07 27.2 In-house 4-156 (272) alignment 
Range on Protein: 502-651
Range on HMM: 4-156/272.0
SDFFHANRIKCPngLQ------LILTQSPLHKildkasTVFKFWWAvRQERVTHIVMLGQVNEEDANW-----N--RMFCKYFPESADGIVKIGGFKISC
|. ..|. .. .   .      |.... ||.       |.  ||.  .......||.| ...| ...         | ..  ......  . .| . . .
sgyiNardvggy..grvvkpgrlyrsggplpl......taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtl

CDMEEDEDVEERTLVVQYE--KEKEFTVTHHLYKSWSMCSVP-ENSKTLLKLIKNvkcsKTPVIVH
  .|  .|.  |.|.. ..   .. ..|.| .| .|   .|| |  ..||.|. .    . ||.||
lseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvH
0051082 (Phosphotyrosine protein) phosphatases II 502-651 1.8e-07 26.4 In-house 3-98 (151) alignment 
Range on Protein: 502-651
Range on HMM: 3-98/151.0
SDFFHANRIKcPNglqLILTQSPLHkildkastvfKFWWAVRQERVTHIVMLGQVNEEDanwnrMFCKYFPESAdgivkiggfkisccdmeededveert
||.......  ..   |.... ||.           |.  .... ...||.| .  | .     .. .|.||                            
sdyinfsyvt.gg...lyrsggpla..........dflellkelgiktivnlrseeerg.....ycpeylpelg..........................

lvvqyekekeFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS-KTPVIVH
          ..|.|  . .|.  ..|.. ...|.... .    . ||.||
..........ievlhipildwpdpglplsfdavleflellldkkngpvlvH
subfamily_PTPN3_pd Subfamily PTPN3 503-652 5e-18 60.0 In-house 66-215 (280) alignment 
Range on Protein: 503-652
Range on HMM: 66-215/280.0
DFFHANRIKC--PN---GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADgIVKIGGFKISCCDMEEDEDV
|.  || ..   |      . | || ||      |.|. .||  | ..... |||| .. |.        ..|.||. |  .. |.|.. |   .|.. .
dyinanyvnmeipstglvnryiatqGPl......aktatdfWqmvweqksslivmlttlverG...rvkChqyWPeted.eleygefsvkcekedetksy

EERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVHG
  | ||.. .. ..| ....  | .|.  .||..|. .|.....|.  .    .||.|| 
vlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC
0043147 (Phosphotyrosine protein) phosphatases II 503-651 7.4e-08 27.8 In-house 6-106 (172) alignment 
Range on Protein: 503-651
Range on HMM: 6-106/172.0
DFFHANRIKCPNGL-QLILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGQVneedanwnrmfckyfpesadgivkiggfkisccdmeededveert
|. .|. ....    ..| || |        .|. .||  .... .||||.| .                                              
dyinasyldlyyipdrfiatqgp......lrntladfwrmlkelgithivnltel.............................................

lvVQYEKEKEFTVTHHLYKSWSMCSVPeNSKTLLKLIKNVKC-----SKTPVIVH
  . . .  | .. ..|| .|   .|| ... ||.... ..      .. ||.||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVH
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 504-652 3.5e-06 20.9 In-house 69-216 (312) alignment 
Range on Protein: 504-652
Range on HMM: 69-216/312.0
FFHANRIK-CPNGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsADGIVKIGGFKI---SCCDMEE----DE
. ||| .| | .  ... ||.||..      |. .||  .     | |..|  . |. ..     .||  .   |.|..   ..   .| ..|      .
yihanfvkictkperfvctqgplen......tcthfwqlalslgstsiillcgfvedgse...kcakyisd.ivgfvdledhrvyteycteieiggkskd

DVEERTL-VVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHG
 .  | | ||     .|  . |. . ||    .|.   | |.|.  ||  | ||| | 
kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 512-652 5.2e-12 40.2 In-house 71-206 (283) alignment 
Range on Protein: 512-652
Range on HMM: 71-206/283.0
CPNGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQYE--KE
  .. . | .||||..      ||  ||  | .|..| |||| .. |.    .   ..|.|.  .| .. | | ..  .    .    . |.....   .
ykqdkkyiiaqsPldr......tvvdfWkmvfdekitaivmltklqedl...rikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssak

KEFTVTHHLYKSWSMCSVPENSKTL--LKLIKN--VKCSKTPVIVHG
... ..|. .  |  ..      .|  . ...    .  |.|..|| 
stlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhC
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 515-652 9.9e-14 46.0 In-house 85-218 (287) alignment 
Range on Protein: 515-652
Range on HMM: 85-218/287.0
GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADgiVKIGGFKISCCDMEEDEDVEERTLVVQYEK--EKEF
  . |...||. .      |. .||  . ...|| |||| | .|.| .   .  .|.||..   | .| ..|.  . |  ... ||.| |. ..  ... 
kkafiiaesPmfn......tarnfWkliddrnvtaivmlcqekendee...vcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkq

TVTHHLYKSWSMCS-VPENSKTLLKLIKN----VKCSKTPVIVHG
.|. . . .|     |.|    || . .      | ..|...|| 
qvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC
0036282 (Phosphotyrosine protein) phosphatases II 517-651 7.2e-08 27.8 In-house 18-110 (174) alignment 
Range on Protein: 517-651
Range on HMM: 18-110/174.0
QLILTQSPLHkildkastvfkFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPEsadgivkiggfkisccdmeededveertlvvqYEKEKEFTVTH
 ||..| ||            ||  ......|..||| . .|   . . ... |.||                                . .  | .. .
rliagqgpla...........fwemlkelgittvvmlleeke...lglykcinywpe................................lredlerlgiq

HLYKSWSMCSVPENSKtLLKLIKNVKCS-----KTPVIVH
.||  |   .||. |. ||...| |.       . ||.||
ylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 519-642 1.3e-06 23.2 In-house 71-179 (284) alignment 
Range on Protein: 519-642
Range on HMM: 71-179/284.0
ILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGqvneedanwNRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKE-FTVTH
| || ||        |.  ||  . . ... ||.|          . . ..|.|   .. .| . ||..   .|| |.   | . .    |||.  ... 
iatqGPld......ntladfWrmiweyncstivllt.........kdkcsqywpl..kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirq

HLYKSWSMCSVPENSKTLLKLIKNVK
. .. |    ||. .  |..|.|.|.
fhflgwpdvgvpdypsdlmrlvkkvr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 519-642 1.5e-06 22.8 In-house 107-215 (319) alignment 
Range on Protein: 519-642
Range on HMM: 107-215/319.0
ILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGqvneedanwNRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKE-FTVTH
| .| |      .  |.  ||  . . ... ||.|          . . ..|.|   .. .| . ||..   .|| ..   | . .    |||.   .| 
iaaqGP......ldntladfWrmiweyncstivllt.........kdkcsqywpl..kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitq

HLYKSWSMCSVPENSKTLLKLIKNVK
. .. |    ||. .  |..|.|.|.
fhflGwpdvGvpdypsdlmrlvkkvr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 532-708 1.1e-20 68.9 In-house 38-225 (255) alignment 
Range on Protein: 532-708
Range on HMM: 38-225/255.0
ASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYE-KEKEFTVTHHLYKSWSMCSVPEN
. || ||. .. | . . .|||.  .||. .      .|||   |.  |.   .... .   |  .  .... ..  | |  ||.|. || |     ||.
sltvdkfyqtivqtktevvvmlcdfaeegve...kcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

SKTLLKLIKNVKCSKtPVIVH---GISRN-----IDLGYQ--MFALNKKTT----FVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAY
.. .|...| |. || .|.||   || |      ..| ||  . .|..  |    ..|.|. |||. .. . .|..  |.|. .. . | . 
areilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg
subfamily_eak_pd Subfamily eak 532-642 1.3e-07 25.3 In-house 103-208 (332) alignment 
Range on Protein: 532-642
Range on HMM: 103-208/332.0
ASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKeFTVTHHLYKSWSMCSVPENS
 . || ||  | ...   ||.| .  |.. .    . ||||. .   .| | ... . .  . . .| | |...   |    | |. .  |.  ..|   
edkvfafwqmvleqkspaivqlledvelkle...ksdkyfpdktreelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkye

kTLLKLIKNVK
  .| | | .|
.dflalrkvmk
subfamily_hpo-7_pd Subfamily hpo-7 533-708 1.3e-18 61.9 In-house 45-231 (263) alignment 
Range on Protein: 533-708
Range on HMM: 45-231/263.0
STVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYE-KEKEFTVTHHLYKSWSMCSVPENS
 |. ||. ...| . . .|||.  |||. .      .|||   |.  |.   .... .. .|  .  . |. . . | |  ||.|. || |     ||..
qtidkfyqtivqtktevvvmLcDfneegve...kcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

KTLLKLIKNVKCSKTpVIVH---GISRN-----IDLGYQ--MFALNKKTT----FVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAY
.  |...| .. ||  ..||   || |      ..| ||  . .|..  |    ..|.|. |||. .. . .|.   |.|. .. . ....
reilnilkvarnsks.lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf