Gene Y39B6A.18 in Caenorhabditis elegans

Synonym: CELE_Y39B6A.18, CELE_Y39B6A.18

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP214_AA protein Get Run
CeleP214_AA_1009-1291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
WSN Domain of unknown function 27-93 9.4e-27 82.7 Pfam-A 2-68 (69) alignment
Range on Protein: 27-93
Range on HMM: 2-68/69.0
KPTDYLDHITIIAHIANGITLQAGLMNGTIQIDEVVGEMLNLGSANVSDLINYKPDKILELIKKLKE
.....|....|||...|||.|||||.||.| ||.|. |.||.||...|.|.....||. | ..||.|
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse

DUF2763 Protein of unknown function (DUF2763) 742-811 6.7e-06 13.0 Pfam-A 19-86 (91) alignment
Range on Protein: 742-811
Range on HMM: 19-86/91.0
QNVPSAFQSFDNFLQLFFASQQTISVPPPNPQSNSGGVNTGGTGNGNGSGGpsGDTGTGPTGSGTGTGAA
. .   | .. .|..||| .   . |  .. ...| . .  ... |.| .|  |  . |. | | |  | 
siivdfflgilefislFFrtllspevekarrknssskkkiddgrGgpgapg..Ggrrlgrigggggpsap

MFS_1 Major Facilitator Superfamily 805-877 5.8e-06 11.5 Pfam-A 127-189 (352) alignment
Range on Protein: 805-877
Range on HMM: 127-189/352.0
GTGTGAAAAVGSSTVSTVSdESSDFPILFVVIPVVLILVALviggiVFIWYRKREEKRKEKEAEEENEkliaE
..|....|..|    . .. .|  .. .|... .|..|.|.     .|...  .|..........| |     
sagfslGailgpllgglla.sslgWravfyilaivsllaav.....lfllllpeepperkrkspkeee....g

TMEM154 TMEM154 protein family 811-871 2.1e-07 22.4 Pfam-A 37-99 (146) alignment
Range on Protein: 811-871
Range on HMM: 37-99/146.0
AAAVGSSTVSTVSDES--SDFpILFVVIP-VVLILVALVIggIVFIWYRKREEKRKE--KEAEEEN
.| |... ..   ...   .. .| ..|| |||||. ||.  .... ..||  ...|  .| |.|.
sanvnleegelseksadqael.vlmiiiPsvvLillllvv..vilvikkkrkrrKqeetsedeked

DUF3377 Domain of unknown function (DUF3377) 818-857 5.6e-06 16.1 Pfam-A 18-57 (74) alignment
Range on Protein: 818-857
Range on HMM: 18-57/74.0
TVSTVSDESSDFPILFVVIPVVLILVALVIGGIVFIWYRK
.| .|.|.|.   .. ||||.|| |  ||.   ..   ||
ivvevddvsgtvnavaVviPlvLalCiLvlvytivqfkrk

DUF1510 Protein of unknown function (DUF1510) 831-943 2.5e-06 16.3 Pfam-A 15-125 (217) alignment
Range on Protein: 831-943
Range on HMM: 15-125/217.0
ILFVVIPVVLILVALVIGGIVFIWYRKREEKRKEKEAEEENEKLIAERERMRAIKEEEeRVKAEREK-----VKKEEERLKAEEEKVKVEKernkekVKA
.| . | .|..|...| . ... .  .......|.|.|.....  .| |..   ..|.   ....|.      |.||.. ..|||| |.|.       . 
vLniaiaiVvvlivivaaqllvgnskskkasadeeeeeksedeekteeeevkeeekea.akdedkeddsesekkdeeseeeeeeekekkee......ese

EEERLKAEEEKVKIEKEK
|.|. ..|.|. ..||| 
edeketeekeesnvekei

0045450 (Phosphotyrosine protein) phosphatases II 1005-1278 4.8e-59 195.9 In-house 7-295 (307) alignment
Range on Protein: 1005-1278
Range on HMM: 7-295/307.0
KLLKVKKVELWTMSLPNKDDHKPAKFYNttiENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK----RAPIHANWV--------PTP
......| .|. . |. .. .. .| ..   . ..||... ....... .   ||.||. ... ..| | . . ..       |.|..|        ...
lfidalkllllvllllldfltgllkefe...kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAARTLTHY
 ....|||||.| . |.|||| |. .. |..|||. . ||.....   | |   .  |. |.| .......   .... .| ..| |. |..  ||.||.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthf

QYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPT---IELTEALKHLHEHRWNGVQTNSQLYW
.|  | . |||.|  |. ...|.|.|      ...|..|||| |.||...||.  .. ||.|...|   . | ||.|.| |.|...||. .|...
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1008-1306 1.1e-179 590.6 In-house 2-300 (301) alignment
Range on Protein: 1008-1306
Range on HMM: 2-300/301.0
KVKKVELWTMSLPNKDDHKPAKFYNTTIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGKRAPIHANWVPTPGHPHRFIATQSPINA
||||.|.|..| ..|||.|.|||||||||||||||||||||||||||||.||||||||||||||||||||||||.||||||.||.||||||||||.|...
kvkkiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkn

TCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHV
|.||||||..||.||.|||.|.|||........|||......|..|||.||..|...|..|.|..|...|.|||||||.||.||||||.|..|||||||.
tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksha

ETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTLGTMYRLIKEYGFDMKIYDQQMAMFN
|...|||.|||||||||||||.|||||.||||||||||.||||||||||||||||.||||||||||||||||||||.||||||||||||||..|.|||.
elfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeqlamfd

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1025-1277 5.1e-30 99.4 In-house 16-268 (287) alignment
Range on Protein: 1025-1277
Range on HMM: 16-268/287.0
HKPAKFYNTTIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVeVIVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHI
.|  . ...    ..  | ..|..| . |   .|| |.  .  .    | .. . .   | | .. .  . ..||...||.  |  .|| .  . .|. |
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrv.llkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMVGRKVEYWKNIHNDYlpmWPRND-LQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERG-VPKSHVETYELMEMVKKS---
||. .. |  ...  .|   || .. . .| . |...| .  |... . | ..|  .. . . .... ||. .| ..| |..       . ||.|.    
vmlcqekendeevcyqy...WpeeksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

-EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
 . .||||||...|||  |.  .   .... . .|.. . ||.    . . ||| .|  
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqyk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1031-1278 7.4e-21 69.1 In-house 22-270 (439) alignment
Range on Protein: 1031-1278
Range on HMM: 22-270/439.0
YNTTIENVNVTTIDKDHITESYAY-LPEDKHRYPTVPCKPSTAVEV-IVD--GKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVM
..   |..| |  |   |.   |    . | ||  |     | | .  .    .   | ||..     .. .|||| | . |..||| . ..  . .|||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

VGRKVEYWKnihndylpMWPRNDLQV-GRFMIKMTNmdFIVQKNIMRRSFKVADSTGKF-AARTLTHYQYSQWAERGVPKSHVETYELMEMV-----KKS
.   || .|         || ..  . |  ....     |   | . | ||| .   .    ||. ...|  | .. ||       ...  .     |. 
ltnlvesyk........ywpsdaevcygdiavrvdr..nielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
  |.||||| |.||. . |  .    |. ..  ...   .| |...| . ||.  |  .
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvf

0040438 (Phosphotyrosine protein) phosphatases II 1032-1292 1.6e-60 200.4 In-house 19-276 (317) alignment
Range on Protein: 1032-1292
Range on HMM: 19-276/317.0
NTTIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK---RAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVG
    |  .. ....|...... .   ||.||| ... ... | . ..|.      |.|..|..| ....|||||.| . |.|||| |.... |..|||. 
alleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

RKVEYWKNIHNDYLPMwpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADStGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIV
. .|....    | |.  .. |..|.|........    ..|  | ..| |. |.   ||.||..|  | . |||.|. .  ...|.|...    ..|..
eleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvl

VHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMtlgtmYRLIKEYG
||||.|.||...||. ... .|.|   .. ..||.|.| |.|...||| .|....     |... || 
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl.....ydalleyl

0043336 (Phosphotyrosine protein) phosphatases II 1034-1278 7.8e-53 175.1 In-house 23-268 (278) alignment
Range on Protein: 1034-1278
Range on HMM: 23-268/278.0
TIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGKR---APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRK
  |  .......|... .. .   ||.||. ... ... | . ..|..     |.|..|... .|..||||| | . |.|||| |. .. |..|||. . 
llefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtel

VEYWKNIHNDYLPmwpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAaRTLTHYQYSQWAERGVPKSHVETYELMEMVKK----SEKPIVVH
||....    | |   .. |..|.| .......   ......| ..| .   ..  || |||.|  | . ||| |     .....|..    |..|..||
velgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVH

CSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
||.|.||...||. ..| .|.|   .. | ||.|.| |.|.. ||| ||...
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf

0049772 (Phosphotyrosine protein) phosphatases II 1034-1279 4.9e-20 67.9 In-house 24-272 (314) alignment
Range on Protein: 1034-1279
Range on HMM: 24-272/314.0
TIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPsTAVEVivD-----GkRAPIHANWVPTPghpHRFIATQSPINATCEDF----------WAMC--
.. ... ... . .|. .. .|  || ||. ... . . | .  .     |  . |.|..| ..    .||||| | . |..||          | |   
vlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil..pglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr

MQYEVEHIVM---------------------VGRKVEYWknihndylPMWPRNDLQVGRfmikmtnmdfivqknimrrsfKVADSTgKFAARTLTHYQYS
 .. |  |||                       .  ..         ....  ||.  .                     .. ..  ..  |.  .| . 
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk.....................eelydp.elferlgikylri

QWAERGVPkSHVETYELMEMVKK--SEKPIVVHCSNGIGRSMAFIGTEYLARQVeadpTIELTEALKHLHEHRW-----NGVQTNSQLYWM
 .   ..| .    .|..|....   ..|..|||. |.||.  |. . || ..      . | |||..... |      . ...  |....
pvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1035-1276 5.3e-17 56.7 In-house 12-248 (267) alignment
Range on Protein: 1035-1276
Range on HMM: 12-248/267.0
IENVNVTTIDKDHITESYAYLPEDKHRYPTVpcKPSTAVEVIVDGKRAP-IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKveY
 |...  . ..  |. |.|   ....|.  .   |     ||.  |    | | .| .    . ||.|| |.. |  ||. . ....|  ||.. .   .
felikkisdtsstisqsiaeknqernrlddn..lpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv..f

WKNIHNDYLPM----WPRNDLQVGRFMIKMTNMDFIVQKNImrrSFKvaDStgkfAARTLTHYQYSQWAERGVPKSHVETYE-L--MEMVKKSEKPIVVH
  ||.  . |        .|| | . . |  |   |.  ..    ||  .     .|. .| | | .|      | ...    .   . ... ..|.||.
tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfk..ne....sahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvva

CSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
||.|.||| .|.  .   ...  . . .. . |... . |   |.|  . 
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1040-1303 7.9e-36 118.7 In-house 32-298 (319) alignment
Range on Protein: 1040-1303
Range on HMM: 32-298/319.0
VTTIDKDHITESYAYLPEDKHRYP-TVPCKPSTAVEVIVDGKRA--PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKN
. . ..|.....     ..| ||.  ...  .  |   .||.     | |... .  . ..|||||.|.. | |||| |  ..|.  .||. . ||  | 
lkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkv

IHNDYlpmWPRND-LQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-----KPIVVHCSNG
  . |   ||...  . ||..... . .   ..... | .|.   ...  .|...|.|| .|.. .||..     .|.. ..||      .|||||||.|
klkky...wpeenfeeyGrlivtleeee..eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

IGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQlYWMTLGTMYRLIKEYGFDMKIYDQQMA
.||  .||  .    .|. . .... .  ..|   |   ||...| | .   ..   .. .  .... | .. 
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq.Ykfiyealleaveagdteievqdlrdr

0039614 (Phosphotyrosine protein) phosphatases II 1041-1279 1.6e-53 177.5 In-house 42-281 (297) alignment
Range on Protein: 1041-1279
Range on HMM: 42-281/297.0
TTIDKDhITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK----RAPIHANWVPTPGH-PHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWK
  .  | ..... .   ||.||. ... ... | . . ..       |.|..|... . ...||||| | . |.|||| |. .. |..|||. . ||...
lslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr

nIHNDYLPMWPRndlQVGRFMIKMTNMDFivQKNIMRRSFKVADsTGKFaaRTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSN
    .| |       . |.| ..... .    .....| ..| . .|.   ||.||.||  | . ||| |.   .|..|.|..      ...|..||||.
.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsa

GIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|.||. .||.  .. .|.|   .. . ||.|.| |.|...||| ||... 
GvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl

subfamily_PTPN13_pd Subfamily PTPN13 1041-1277 3.6e-31 103.4 In-house 24-259 (273) alignment
Range on Protein: 1041-1277
Range on HMM: 24-259/273.0
TTIDKDHITESYAylPEDKHRYPTVpcKPSTAVEVIVDGKRAPIHANWVPTP--GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIH
 ..|. ..... .   .|| ||  |   |  .  |..... . | |...  |   . ...||.| |.  |..||| |  . ..| |.||  ..|  |   
kpldtcevgkkke..nkdknryrnv..lPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

NDYLPMWPRNDLQVGR-FMIKmtNMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELME---MVKKSEKPIVVHCSNGIGRS
. | |   .. |.|   . ..  ...   ...   |...| ||  . ..| ..| .. .| . |||.| .|  ...     ..... ||||||| |||||
hrywPesknkklkvsnrleve..llkvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrs

MAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
 ..|  . .   .| |  ....| ...| | |   |||. |  
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyi

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1041-1281 1.2e-25 85.6 In-house 44-285 (319) alignment
Range on Protein: 1041-1281
Range on HMM: 44-285/319.0
TTIDKDHITESYAYLPE--DKHRYPTVPCKPSTAVEV-IVDGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkveywK
. .  .  . ..| |..  || |.  .     . | .  ..|.     | | .|    .. ..||.| | . | .||| |  .|..  ||..       |
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......k

NIHNDYLPMwpRNDLQVGRFMIKMTNMDFIVQknIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVK------KSEKPIVVHCSN
.   .| |   . . . .|| .|.. ..   .   . |...... . .   | .| . .  | . |||.. ..   |.. |.      . ...|||||| 
dkcsqywpl..kivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTL
|.||. ..|  . |  ... .  ... . .. | . | . ||   | ...  
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

subfamily_egg_pd Subfamily egg 1042-1252 8.4e-19 62.4 In-house 26-233 (307) alignment
Range on Protein: 1042-1252
Range on HMM: 26-233/307.0
TIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIV-DGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYwkNIH
..|.  .|....    .| | . |.|| |. |.. .  |.     |||| |        || .|.|.  | .||| | .| ||..|||.  ..|   .  
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

NDYlpmWPRNDLQVGRF---MIKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYsQWAERGvpKSHVeTYELMEMVKKSEKPIVVHCSNGIGRSM
. |   ||. . .  ..    ....|..   . . . |  |.    |.   | | |.|. .. . .  . .   .... ....  ||.||.. .|. .. 
eyy...wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss..dvys.plrvlrklrnlskpvvvqdilGvskaa

AFIGTEYLARQVEADPT
...  |    ..   |.
tlvaieiallsllrGpi

subfamily_PTPRB_pd Subfamily PTPRB 1043-1279 9.8e-36 118.3 In-house 37-277 (293) alignment
Range on Protein: 1043-1279
Range on HMM: 37-277/293.0
IDKD-HITESYAYLPEDKHRYPTVPCKPSTAVEV-IVDG--KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIH
..||  .. . .   ..| ||  .     . |..  ...  .   | ||..|    |. ||||| |.  | .||| |... ... |||. . ||  |   
vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

NDYlpmWPRN--DLQVGRFMIKMTNMDfiVQKNIMRRSFKVADstgKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS------EKPIVVHCSNG
..|   ||..  . . |   ..... .  .... . |..|.     . . |....|..  |.. |||..     .....|...      ..||||||| |
eeY...WPadeepvlyGdikvtlvaee..eledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaG

IGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
.||. .||  . | ...| . .....  . .| |.| . |||..|  ..
vGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi

0050432 (Phosphotyrosine protein) phosphatases II 1045-1279 2.2e-56 186.8 In-house 57-291 (308) alignment
Range on Protein: 1045-1279
Range on HMM: 57-291/308.0
KDHITESYAYLPEDKHRYPTVPCKPSTAVEVivDGKRAPIHANWVPTP--GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYL
   .. ..     ||.||. ...  .. | .  |..   |.|..|...  ..|..|||||.| . |.|||| |.....|..|||. . ||. ..    | 
lleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYw

PMWPR-NDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS--EKPIVVHCSNGIGRSMAFIG
|. .  . |..|.| .......   ......| ... .. ..   ||.||..|  | . ||| |  .  ...|.|.||  ..|||||||.|.||...|| 
plelgggsleygkftvtllseev..lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfia

TEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
 ..| .|.|.. .. . ||.|.| |.|.. ||| .|....
ldllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

DSPc_SM00195 1045-1279 9.1e-51 168.1 In-house 16-254 (263) alignment
Range on Protein: 1045-1279
Range on HMM: 16-254/263.0
KdHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDY
| ..||.     ..|.||  ...  .| |..  .    .   |.||.. .. .....|||| | . |.|||| |... .|. |||. . .|  |.  ..|
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

LPMWPRNDLQVGRFMIKMTNMDFIVqKNIMRRSFKVADSTGkFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEK----PIVVHCSNGIGRSMAF
 |    .  ..|.. .|... .    ..| .| ...   .    .|..|.||| .| ..|||.|. .. ||...||||..    |||||||.|.||. .|
wpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
. .... ...|.. .... | .|.| ..| . |||  |. ..
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

PTPc_SM00194 1045-1279 9.1e-51 168.1 In-house 16-254 (263) alignment
Range on Protein: 1045-1279
Range on HMM: 16-254/263.0
KdHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDY
| ..||.     ..|.||  ...  .| |..  .    .   |.||.. .. .....|||| | . |.|||| |... .|. |||. . .|  |.  ..|
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

LPMWPRNDLQVGRFMIKMTNMDFIVqKNIMRRSFKVADSTGkFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEK----PIVVHCSNGIGRSMAF
 |    .  ..|.. .|... .    ..| .| ...   .    .|..|.||| .| ..|||.|. .. ||...||||..    |||||||.|.||. .|
wpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
. .... ...|.. .... | .|.| ..| . |||  |. ..
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi

0045098 (Phosphotyrosine protein) phosphatases II 1046-1279 5.8e-48 159.0 In-house 23-264 (278) alignment
Range on Protein: 1046-1279
Range on HMM: 23-264/278.0
DHITESYAYLPEDKHRYPTVPCKPSTAVEvivdgkrAPIHANWVPTPghPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPmw
. ||..    . ||.||. ... ... |          |.|......  |..||||| | . |..||| |. .. ...|||. . ||. ..    | |  
seitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp..

PRNDLQVGRFMIKMTNMDFIvqKNIMRRSFKVADS---TGKFAARTLTHYQYSQWAERGVPKSH--VETYELMEMVKK-----------------SEKPI
... |. |.| ....... .  ...  | ..| .       .  |..||..|  | . ||| ..      ||.|....                 |..|.
eggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSNGIGRSMAFIGTEYLARQVeaDPTIELTEALKHLHEHRWN-GVQTNSQLYWM
.|||| |.||. ....  .. ...  .... | ||.|.| ..|..  ||. .|....
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1046-1277 4e-23 77.1 In-house 36-278 (325) alignment
Range on Protein: 1046-1277
Range on HMM: 36-278/325.0
DHITESYAYLPE--DKHRYPTV-PCKPSTAVEVI--VDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEvEHIVMVGRKVEYWKNIHND
| |.   | .||  .| |.. | . . | .| .    |..   | |... .    . |.|.|.|  || .|.| . ....   .|.|  ...  |.    
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcav

YLPMWPRNDLQVGRFMIKMTNMDFIvqKNIMRRSFKVADSTGkFAARTLTHYQYSQWAERGVPKSHVETYELMEM-------VK---KSEKPIVVHCSNG
| |    .  . | . .|.  .. |   . . | ..| .  .   .|..  .|.  | . ||.|       ....       |.   |.  ||.||||.|
ywpkemgksktfGglevklrtieei..sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

IGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
.||. .||    .. .|  .  ... . .|.| ..| . |.|  |  
vGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyi

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1047-1291 9.7e-10 32.5 In-house 38-278 (303) alignment
Range on Protein: 1047-1291
Range on HMM: 38-278/303.0
HITESYAYLPEDKHRYPTVPCKPSTAVEViVDgkRAPIHANWVPTPGHpHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKnIHNDYlpMWP
...        || |.  | |   . |..  |   . |||...    . .. | || |.. |. ||| | ..  |  ....    || | .  |.  ..|
svsknqfvknmdknrfvdvicldhskvkl.sd..ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydk.lggds..vfp

RND--LQVGRFMIKMTNMdfiVQKNIMRR-SFKV-ADSTGKFAARTLThYQYSQWAERGVPKS-----HVETYELMEMVKKS--EKPIVVHCSNGIGRSM
||.  |.    .|.. ..    . ...   ..|| . | |.. .     ..| .|    .|         . ..|  ...|    .| |     | ||. 
rnqdflkfeersirvgef...krvelgdgwvlkvlsvsngdyksflhv.hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

AF--IGTEYLARQVEaDPTIELTEALKHLHEHRWNGVQTNSQLYWmtlgtMYRLIKEY
.|  . | .|. . | .....|   |. . . |   ||  ||.       .| |. |.
tfalfetahlslhse.qasldlvkclenvrngrlhavqnlsqfsv.....vytllaeh

0046845 (Phosphotyrosine protein) phosphatases II 1048-1279 1.6e-53 177.3 In-house 20-266 (284) alignment
Range on Protein: 1048-1279
Range on HMM: 20-266/284.0
ITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK----RAPIHANWVPTP-----GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIH
.. ....   .|.||. ...  .. | . . ..       |.|..|...      ....||||| | . |.|||| |.....|..|||. . ||. .. .
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

NDYLPMWpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS------EKPIVVHCSNGIG
  | |..  . |. |.|........   ......| ... .   .   ||.||..| .| ..||| |     |....|...      ..|||||||.|.|
aqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RSMAFIGTEYLARQVEADP---TIELTEALKHLHEHRWNGVQTNSQLYWM
|...||  ..| .|.|..    .. . ||.|.| |.|.. ||| .|... 
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

0051299 (Phosphotyrosine protein) phosphatases II 1048-1279 1.6e-52 174.1 In-house 41-278 (288) alignment
Range on Protein: 1048-1279
Range on HMM: 41-278/288.0
ITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK---RAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPM
.. ..     .|.||. ...  .. | . | ..      |.|...... ....||||| | . |.|||| |.....|..|||. . ||. ..    | |.
lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl

wpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADST---GKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAF
  .. |..|..........   ..... | ..| . .   |.   || ||..| .| . ||| |  .  .....|.|.    ..|.|||||.|.||...|
..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtf

IGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|  ..| .|.|.  .... ||.|.| |.|.. ||| .|... 
ialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv

0040439 (Phosphotyrosine protein) phosphatases II 1049-1278 2.7e-51 170.0 In-house 4-237 (249) alignment
Range on Protein: 1049-1278
Range on HMM: 4-237/249.0
TESYAYLPEDKHRYPTVPCKPSTAVEVIVDGKRAP---IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMw
.... .   ||.||| ... ... | . . ... .   |.|...... ...|||||| | . |.|||| |. .. ...|||. . ||....    | |. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

pRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADStGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIG
 .. |..|.|........    .....| ... .. ..   || .|.||  | . |||.|  .. ...|.|.|      ...|..||||.|.||. .||.
.ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

TEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
  .. .|.|   .. | ||.|.| ..|...||. .|...
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1052-1314 4.3e-25 83.1 In-house 38-301 (312) alignment
Range on Protein: 1052-1314
Range on HMM: 38-301/312.0
YAYLP-EDKHRYPTVPCKPSTAVEVIVDgKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLP-MWPRND
 |.|   |  ||| . |       .  | .   ||||.|    .| ||..||.|.. ||  || ...      |...   ||   .    |.  .    |
taflkfkdlnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

LQVGRFMIK---MTNMDFIVQKNIMRRSFKVA-DSTGKfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLAR
|.  |   .     ..    . .|  | .||   .||.     | |||.. | . |.| |   .. |.  |||  ||.. ||| |.||. ...  | .  
ledhrvyteycteieiggkskdkithrvlkvvvkatgq..esklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmia

QVEADPTIELTEALKHLHEHRWNGVQTNSQlYWMTLGTMYRLIKEYGFdMKIYDQQMAMFNDVVKRLEA
 .      .. ...  |   |   |..  | | ..| ..  ..   |. .|  .|... |...  ...|
alrhprkqnvkdsfvllrkdrarsvrvfpq.yvyalrcvleflyskgl.ykrneqewtkfketyakika

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1053-1279 5.6e-36 119.1 In-house 38-268 (281) alignment
Range on Protein: 1053-1279
Range on HMM: 38-268/281.0
AYLPEDKHRYPTVPCKPSTAVEVIVDG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPmWPRND
|     |.||  .     | |.|  .    .   | ||.||.   ....||||.|. |....|| | ....|. |||| |..|  |     | |  ....
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnse

LQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKfaARTLTHYQYSQWAERGVPKSHVETYELMEMV-----KKSEKPIVVHCSNGIGRSMAFIGTEYLA
|..| ...|.|.     ... ..| ||.  ..|.  .|.... .| .| . |||..  |  |  . |     ||.. |.|.||| |.||. ..|. . |.
lkygdvtvkstaee..ekatyierkfkleresge..treveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

RQVEAD-PTIELTEALKHLHEHRWNGVQTNSQLYWM
..|||. ....... ...| ..|   |||  |  ..
kaveaeleeldvkavvaelrkernlmvqtvvqyefv

0037934 (Phosphotyrosine protein) phosphatases II 1054-1278 1.1e-42 141.7 In-house 8-233 (243) alignment
Range on Protein: 1054-1278
Range on HMM: 8-233/243.0
YLPEDKHRYPTVPCKPSTAVEVivDGkRAPIHANWVPTPGhphRFIATQSPINATCED----FWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPmwprND
.   .|.||..... . . | .  .|    |.||... ..   |.|||| | . |.||    || |. .. ...|||. . ||....    | |    ..
penlsknrysdilpydhsrvkl..eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....ge

LQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVK------------KSEKPIVVHCSNGIGRSMAF
 . |.|.......     .... | ...     .   |. .||.|  | . ||| |.   ......|.            .|..|..|||| |.||. ..
vtygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IGTEYLARQVeadpTIELTEALKHLHEHRWN-GVQTNSQLYW
|   .. ...    .. | ||.|.| |.|.. .||| ||...
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrf

0047943 (Phosphotyrosine protein) phosphatases II 1055-1279 8.4e-54 178.2 In-house 37-264 (273) alignment
Range on Protein: 1055-1279
Range on HMM: 37-264/273.0
LPEDKHRYPTVPCKPSTAVEViVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRN-DLQVG
   ||.||. ...  .. | .  ||.   |.|..|... ....||||| | . |.|||| |.... |..|||. . || ... .  | |..  .  |..|
enkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltyg

RFMIKMTNMDFivQKNIMRRSFKVADSTGKFaARTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIGTEYLARQV
.| .......    .... | ... ..  .   || ||..|  | . ||| |  .  |..|.|.|      |..|.|||||.|.||...||  ..| .|.
kftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldql

EADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|.  .. . ||.|.| ..|...||| .|....
ekeggvdvleavkllrsqRpgmvqtpeqyrfl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1055-1280 1.1e-34 114.5 In-house 54-282 (305) alignment
Range on Protein: 1055-1280
Range on HMM: 54-282/305.0
LPEDKHRYPTVPCKPSTAVEVIVDGKRAPIHANWVPTPGHPH-RFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDL--Q
. . | ||  |||.  .|| .        ||||.|  |  |. |||..| |.. | ..|| | .|  ||.|||. . ||  |    .| |.   . |  .
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

VGRFMIKMTNMDFIV-QKNIMRRSFKVADSTGKfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLA-RQVEA
 |  . ...    .  . .|    .... | ..    .. | |...| .||||  .. . ||.  .. |. ||||||| ||||. . .  ||.  .  | 
sgivvenvsgskpmerdaeiqitllnltysgdq..kmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaen

DPTIELTEALKHLHEHRWNGVQTNSQLYWMT
 |   . | .| | ..|   .|.. |  .. 
kpcppmpelvkalrdqrafsiqndvqylfih

0042113 (Phosphotyrosine protein) phosphatases II 1056-1279 9.5e-50 164.6 In-house 9-235 (245) alignment
Range on Protein: 1056-1279
Range on HMM: 9-235/245.0
PEDKHRYPTVPCKPSTAVEVIVDGKRA---PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwpRNDLQV
  ||.||. ... ..| | . .|| .    .|.|..|... ....||||| | . |.|||| |. .. ...|||. . .|....    | |.  .. |..
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslty

GRFMIKMTNMDFivQKNIMRRSFKVADsTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK-----SEKPIVVHCSNGIGRSMAFIGTEYLARQV
|.|........    .....| ..| . .|..  |. .||.|  | . ||| ..    ...|.|.|     |..|..|||| |.||...||.  ....|.
gdftvtllseeh..lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

EADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|.  .. | ||.|.| ..|.. ||| ||....
ekelgvsleeavkelrsqRpgavqtpsqyrfl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1056-1279 1.6e-35 117.6 In-house 41-269 (307) alignment
Range on Protein: 1056-1279
Range on HMM: 41-269/307.0
PEDKHRYPTVPCKPSTAVEVIVDGKRA-PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGR
  || ||  |.|.  . . | .||  .  ||||.. .  .|..||..| | ..|  .||||..| .|| ..|. . .|  |   ..| |.   . |  | 
ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfge

FMIKMTNMDFIVQKNIM-RRSFKVADSTGKF--AARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLAR-QVEAD
    ..  .. ..|        .|..   ..   .||..|.|...| .||||.  . . .|.| |.  . |.||||| |.||| . ..  ..    ..  
apntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGi

PTIELTEALKHLHEHRWNGVQTNSQLYWM
   .. . .. | ..|   .||. |  ..
nckdmkklveelrsqrhyaiqteaqylyl

subfamily_PTPN6_pd Subfamily PTPN6 1056-1278 2.1e-25 84.3 In-house 96-288 (306) alignment
Range on Protein: 1056-1278
Range on HMM: 96-288/306.0
PedkhryptvpckpstavevivdgkrapihanwvptpghPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLqVGRf
                                        ...||||  ...| .||| | .| . . |||. ..||  |.    | |   ...   |. 
s......................................dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGk.

mIKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS--------EKPIVVHCSNGIGRSMAFIGTEYLARQV
 |..||..   ... . |...|.  . |  .|.. .|.. .| . ||||.     ...| |..         . |||||||.||||  .|| .. | ...
.isvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkli

E---ADPTIELTEALKHLHEHRWNGVQTNSQLYW
|    |  |.. .. | ..|.|   |||..|  .
ekkgldadidiqklvksvreqrsglvqteqqykf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1056-1275 6.8e-21 69.2 In-house 37-257 (281) alignment
Range on Protein: 1056-1275
Range on HMM: 37-257/281.0
PEDKHRYPTVPCKPSTAVEVIV--DG--KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQ
 . | ||  .||   . |.. |          ||||.. .|   . .| || | . |  ||| |  | .   |||. . .|  ..   .|.|   .  ||
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

VGRFMIKMtnMDFIVQKNIMRRSFKVADStGkfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
. .. ..    |  |.| ..   ....   |   .| .||. . .| .  ||.|     ...  ..    | |.||| |.||| ...  |   . . .  
fdklsvsy..edstvnkslvttrlnlsye.g..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshf

TI-ELTEALKHLHE-HRWNGVQTNSQ
|. .. . . ||.   |   |||  |
tlpdikqivshlrvtgraasvqtlqq

subfamily_PTPN9_pd Subfamily PTPN9 1057-1278 3.4e-30 100.1 In-house 43-281 (297) alignment
Range on Protein: 1057-1278
Range on HMM: 43-281/297.0
EDKHRYPTVPCKPSTAVEVI-VDGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVG
  | ||  | |  .| | .  ||..     |.||.|    ... ||||| |.. |..||| |  . ||  |||. | ||  .   . |   || .. .. 
leknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqy...Wpleeessa

RF-MIKMTNMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK-----------------SEKPIVVHCSNGIGRSM
.|  ....|..  .... . |.... ... .   |..||.|.  | . |||.|  .  ...|.|..                 |. ||||||| ||||. 
efgdlsvsnveveeeedykvrvleiknvkte.esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtG

AFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
.||  ..   ..|   |....|..|.| . |   .||. | ..
tfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1057-1277 1e-27 92.0 In-house 29-258 (274) alignment
Range on Protein: 1057-1277
Range on HMM: 29-258/274.0
EDKHRYPTVPCKPSTAVEVIVDGKRAP----IHANWVPTPGH-PHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQ
. | || |.   . . | .  .  ...    | ||..  ...  . ..||| |.  | .||| |  | ||. |||. .  |  ..  . | |     ...
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

VGRFMIKMTNMDFIVQKNIMRRSFKVADSTGkfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-------KPIVVHCSNGIGRSMAFIGTEYLA
     ..... . . ...   |.. .  ..     |...|| |..| .. .|..  .  .|.. |..|.        |.||||| ||||  .||...   
erygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

RQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
||.... .... .   .|  .|   |||..|  
rqlreeivvdvlkivcnlrldrGGmvqtseqye

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1057-1290 7.3e-26 85.8 In-house 36-273 (285) alignment
Range on Protein: 1057-1290
Range on HMM: 36-273/285.0
EDKHRYPTVPCKPSTAVeVIVDGKRAPIHANWVPTPGHPH-RFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRF
 |  ||  | |   | | |. .  |  |||.|.  ||. .  .|.|| |.  |  ||| |  | .. ...|.   .|   .    | |    . ...|..
pdlnryadvrcieetrv.vlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

MIKMTNMDFIVQKNIMRRSFKVADSTGK-FAARTLTHYQYSQWAERGVPKSH---VETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
 | .|.         .  .. | ..         . | |   | ..  |.     .| |. .. |.  ||||.|||| |.||. .|.| .| . ..  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenp

TIELTEALKHLHEHRWNGVQTNSQLYWMTLGTMYRLIKE
 ||. . .. ..  |.. ||.  |. .. .  |  .| |
niemldivremramrfqavqshmqflflyvvlmeyfige

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1057-1278 2.8e-23 77.1 In-house 39-268 (287) alignment
Range on Protein: 1057-1278
Range on HMM: 39-268/287.0
EDKHRYPTVPCKPSTAVEVIVDGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWpRNDLQVGR
  | ||  |     | | .  .|.   . | ||.|..  . ..|||.|.|| ||  ||| . .. ..  .... |.||  ..    | |   .  ..|| 
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGG

FMIKMTNMDFIvQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETY-------ELMEMVKKSE--KPIVVHCSNGIGRSMAFIGTEYLAR
. . . . |   . .   |.....|  ..  || .  ... .| ..... . |          . .|. ....   |.|||.. |||||  .. |  | .
ysvvlldydik.ePeygvralrlidletr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
. |    .. . .. .| |.|   ||.  ||  
rledlGrvdvaavvirlreyraalvqavvqlrl

0036941 (Phosphotyrosine protein) phosphatases II 1058-1306 3.7e-62 205.6 In-house 41-295 (297) alignment
Range on Protein: 1058-1306
Range on HMM: 41-295/297.0
DKHRYPTVPCKPSTAVEViVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMI
.|.||. ... ..| | .  |..   |.|..|........||||| | . |.|||| |.... |..|||. . ||....    | |.. .. |..|.|..
eknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftv

KMTNMDFIVQKNIMRRSFKVADStGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIGTEYLARQVE---
...... .  ... .| ..| |  |.   ||.||..|  | . ||| |. .  ...|.|.|      |..|..||||.|.|||..||. ... .|.|   
tllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledkl

ADPTIELTEALKHLHEHRWNGVQTNSQLYWMtLGTMYRLIKEYGFDMKIYDQQMAMFN
  ... . ||.|.| |.|.. ||| .|....   ... |.| . ... .... .....
keggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepllklvlllls

Y_phosphatase Protein-tyrosine phosphatase 1058-1279 1.7e-51 170.3 Pfam-A 3-229 (235) alignment
Range on Protein: 1058-1279
Range on HMM: 3-229/235.0
DKHRYPTVPCKPSTAVEV-IVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
.|.||.....  .| |..   .|.   |.||.| .  ....||||| |.. |.||||.|..|..|. |||. . .|  ..  ..| |   .. |. |.. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT
.....     .|... | ... ..... . |......| .| ..|||.|  .  .|...|.||.    .|.|||||.|.||.. |.  ..| .|.||. .
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

IELTEALKHLHEHRWNGVQTNSQLYWM
... ...|.| ..| . ||. .|....
vdvlqivkelRkqRpgmvqsleqYifl

Y_phosphatase Protein-tyrosine phosphatase 1058-1279 1.7e-51 170.3 In-house 3-229 (235) alignment
Range on Protein: 1058-1279
Range on HMM: 3-229/235.0
DKHRYPTVPCKPSTAVEV-IVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
.|.||.....  .| |..   .|.   |.||.| .  ....||||| |.. |.||||.|..|..|. |||. . .|  ..  ..| |   .. |. |.. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT
.....     .|... | ... ..... . |......| .| ..|||.|  .  .|...|.||.    .|.|||||.|.||.. |.  ..| .|.||. .
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

IELTEALKHLHEHRWNGVQTNSQLYWM
... ...|.| ..| . ||. .|....
vdvlqivkelRkqRpgmvqsleqYifl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1058-1280 7.2e-39 128.3 In-house 50-280 (305) alignment
Range on Protein: 1058-1280
Range on HMM: 50-280/305.0
DKHRYPTVPCKPSTAVEVIVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVG----
.| ||  | |     | .        ||||.| ||  |.||| ||.|.. || ||| ||.|  || | |.   .|   .   .|..   .. |.      
gknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgq

RFMIKMT---NMDFIVQKN-IMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEA
. ..|.    ...|  . .  ....  | . .|.  ||  ||| . .| .|||| . .   ||.|  . |  ||||||| ||||. . .  ||.  |. |
kisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqlla

DPTIELTEA-LKHLHEHRWNGVQTNSQLYWMT
   || |.  |... | | | .||. |  .. 
gqiiedtdkilqkireqrnnsiqtdaqylfvh

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1058-1279 1.7e-35 117.4 In-house 49-271 (288) alignment
Range on Protein: 1058-1279
Range on HMM: 49-271/288.0
DKHRYPTVPCKPSTAVEVIV---DGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDL--QV
.| ||. .     ..|..       .   | |...   .. ...||||.|. .| .||| .  ..... |||.   ||  |.  ..|   || .|   . 
kknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeY...WPdadkpkny

GRFMIKMTNMDfiVQKNIMRRSFKVAdstGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS---E-KPIVVHCSNGIGRSMAFIGTEYLARQVE
| . .....     ..... |.. .     |   ...|.|||  |.. |||.|. .  ||...|| .   . .||.||||.|.||.  ||  . |  .||
Gsvtvtlvesk..eledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidave

ADPTIELTEALKHLHEHRWNGVQTNSQLYWM
.. .|........| ..| . ||| .|  ..
eedyiDvagtvaklRkqRallvqtlkqYefi

subfamily_PTPN3_pd Subfamily PTPN3 1058-1278 4.1e-33 109.5 In-house 43-266 (280) alignment
Range on Protein: 1058-1278
Range on HMM: 43-266/280.0
DKHRYPTVPCKPSTAVEViVDGKRAPIHANWV----PTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwPRNDLQVG
.| ||  .    .| |.. ....   | ||.|    |. |   |.|||| |.. |..||| |  . ... |||.   ||  .     | |  . . |. |
sknryrdilpydatrvkl.kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleyg

RFMIKMTNMDfiVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEA
.|..|... |   .|... | . . |.. |   |.... || .|.. |||... .  |..| |.|     |.|.||||| ||||.  .|  |     .||
efsvkceked..etksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea

DPTIELTEALKHLHEHRWNGVQTNSQLYW
   .   . .... . | . |||.||  .
aepvypldivrtmrdqramlvqtasqykf

0041856 (Phosphotyrosine protein) phosphatases II 1058-1281 7.4e-33 109.0 In-house 3-165 (182) alignment
Range on Protein: 1058-1281
Range on HMM: 3-165/182.0
DKHRYPTVPCKPSTAvevivdgKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrKVEYWKnihndylpmwprndlqvgrfmi
||.||. ... . .            |.||..  . .. |||||| | . |..||. |  .. . .||..   . ||                       
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywp......................

kmtnmdfivqknimrrsfkvadstgKFAARTLTHYQYSQWAERGVPKsHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQveadpTIELTE
                         ..  |. ..|.| .|   |||    |.....|.|.....|..|||| |.||. ....  .. ..      . |.|
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

ALKHLHEHRWNGVQTNSQLYWMTL
|.|.. ..|...|.| .|...  |
avklvrsrRpgmvitpnqyfflql

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1058-1296 3.9e-31 102.8 In-house 58-287 (290) alignment
Range on Protein: 1058-1296
Range on HMM: 58-287/290.0
DKHRYPTVPCKPSTAVeVIVDGK-RAPIHANWVPtpGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
 | ||  |.|   | | .. ||     .|||.|   |    || || ....|  |.| | .| .|  |||.   .|  |   ..| |    . |  | . 
kknrykdvvcndktrv.ilkdGydGdyvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

IKMTNMDfIVQKNIMRRSFKVADST-GKfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIEL
.  .. |   ..||... . | |   ||     | |..   | .. |..| .    .. ...|   |.||||| ||||. .|.  |  .. .     ..|
vlcseed.dkdaniikktlsvrdkdsGk..ehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldl

TEALKHLHEHRWNGVQTNSQlYWMTLgtmyRLIKEYGFDMK
 .  . | . | | || . | | . .    ... ..| |.|
ldlvralrnsrlnsvqvdiq.ylalv....eilldlGkdfk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1058-1279 9.3e-18 58.8 In-house 54-282 (310) alignment
Range on Protein: 1058-1279
Range on HMM: 54-282/310.0
DKHRYPTVPCKPSTAVEVIVDGKRA--PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRF
 | ||  | |. .. | . .|  |    ||||.| |      || .| |.. |  ||| | .|   | |... . .|  .     |   ||   .     
hknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy...wpslgvtetyg

MIKMTNMDFIVQK--------NIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQV
 |..||.    ..         ..     | .   ..    ..  .. .| .||||  .. |     . .    | ||||| |..|  . .  ..   ..
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkl

EADPTIELTEALKHLHEHRWNGVQTNSQLYWM
.    ... |   .|. .|   .||. |  ..
drglkvdaeevktellksraiciqtelqylii

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1059-1291 2.9e-32 106.9 In-house 46-276 (288) alignment
Range on Protein: 1059-1291
Range on HMM: 46-276/288.0
KHRYPTVPCKPSTAVEVIvDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIK
. ||  .|.   | | .  |     |.|| |..  ...|.| .|.|.|.| | .| | .. .||.|||. . .|  |.  ..|.|.   .  ..||.   
rdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctv

MTNMDFIVQKNIMRRSFKVADSTGKFAarTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEA
. .    ..| .    ...   . .     . .  . .| . |||....    |.|..|. .||||||.|.|.||....| .   ....  |  . . . 
vkkkradidklvkvsllriskegeekv..ivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsl

LKHLHEHRWNGVQTNSQ-LYWMTLGTMYRLIKEY
|..| |.| . .||. | ||   .   . |.| |
laklreerfkaiqtemqylyvhrcvleelllkky

subfamily_PTPN1_pd Subfamily PTPN1 1059-1279 8.7e-26 85.3 In-house 35-263 (290) alignment
Range on Protein: 1059-1279
Range on HMM: 35-263/290.0
KHRYPTVPCKPSTAVEvIVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPR-NDLQVGRFMI
. ||  |     . .. . ...   | |. |  .   ...| || |.  |.. || |  . .   .||. . ||  ..   .| |.  . . |..    .
lnryrdvspydhsrik.leradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtkl

KMTNMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS------EKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
|.. .   .... ..| ... . . .  .|...|. | .|.. |||.|     ...  |..|        | |.||| ||||| .|.  . .  ..|.  
kvkliseerksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkd

T---IELTEALKHLHEHRWNGVQTNSQLYWM
    ... . | .| ..|   .||  || . 
dlssvdikkvllelrkyrlGliqtadqlrfs

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1059-1278 5.8e-16 52.9 In-house 48-227 (392) alignment
Range on Protein: 1059-1278
Range on HMM: 48-227/392.0
KHRYPTVPCKPSTA--VEVIVDG-KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWknihndylpmwprndlqvgrf
| ||  .    |.   .||| |  ..  . | ..|.    . .||.|.|  |. .||| | .| .|  |.|| .  |                       
knryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....................

mikmtnmdfivqknimrrsfkvadsTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
                          |.  ||| . .....| ...|||      .... ||       .|...||| |.||.   |  . .  . .   
.........................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktr

TIELTEALKHLHEHRWNGVQTNSQLYW
 ... . .  ....|   |||. |  .
mvdvfnfvtnirrkrpymvqtkeqyaf

subfamily_CG42327_pd Subfamily CG42327 1060-1208 2.2e-08 28.1 In-house 32-182 (319) alignment
Range on Protein: 1060-1208
Range on HMM: 32-182/319.0
HRYPT-VPCKPST--AVEVIVDGKRAPIHANWVPTPGHP-HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRF
 |.   ||  ..     ..  | |   ..|..|  .      .||.| . . .  ||| .  .     || .    |   .   .|||     | .    
srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyG

MIKMTNMDFIVQKNiMRRSFKVADSTGKFAARTLTHYQYsQWAERGVPKSHVE
 |..|  .  |...    |  .     |  .| |||| | .| | .|| ..  
dilvtlkgrevkdr.yaistlllkrvdkeesrelthywy.kwleaevPaeeaa

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1061-1279 2.4e-30 100.4 In-house 25-256 (270) alignment
Range on Protein: 1061-1279
Range on HMM: 25-256/270.0
RYPTVPCKPSTAVEV---IVDGKRAPIHANWVP-TPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
||  .  .| | | .     | . | | ||.|.   |.....||...| ..| ..|| | .. .|. |||.   .|  ..  . | |  | . ...   .
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgk

IKMTNMDFIVQKNIMRRSFKVAdSTGKfaARTLTHYQYSQWAERGVPKSHV---ETYELMEMVKKS-------E--KPIVVHCSNGIGRSMAFIGTEYLA
||....    ..  ...  ..  ..|.   | |.|..| .| ..|||...    .| .|..|...        .  .|..||||.|.||.  .| ...  
ikvlalseekeegyiltrlrle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiav

RQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
| .| .  ..... ...| ..| . ||.  |  ..
rlLeetkkvdvlaiieelRkdRmalvqhpeqyefl

subfamily_PTPRK_pd Subfamily PTPRK 1077-1277 7.9e-31 102.0 In-house 65-267 (314) alignment
Range on Protein: 1077-1277
Range on HMM: 65-267/314.0
VDGK--RAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIKMTNMDfiVQKNIMRRS
.||      | |... .  .|. ||.|| |.. | .||| .  ...   |||.   ||  .     |   || .  . | . ... ...  ...... | 
idgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky...WPedtevygdikvelvete..llaelvvri

FKVAD-STGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNG
|.|   . |. . |.. ..|. .|.. .||.|     .|.  ||||.     .||||||.| ||. .||  . .   .| . .... .| | | ... | 
frveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnm

VQTNSQLY
|.|. |  
veteeqyk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1078-1276 1.1e-27 91.8 In-house 74-268 (315) alignment
Range on Protein: 1078-1276
Range on HMM: 74-268/315.0
DGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIkmTNMDFIVQKNIMRRSFkv
| .   . ||...   ...|.||.|.|  |. .||| . ..... .|||.   ||  |.  . |   || ...  |.. .  | ..  |....  |..  
dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky...wpdkkviyGkitv..trkseevnteytvrtl..

aDSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTN
   . .   |..  ..|. | . ||||. .   .|.  ||.    |  .||||||.|.||. .||  . .  |.||.  |.. .... . . | . ||. 
.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

SQL
 | 
eqy

subfamily_PTPRG_pd Subfamily PTPRG 1078-1279 4.5e-27 89.5 In-house 70-279 (563) alignment
Range on Protein: 1078-1279
Range on HMM: 70-279/563.0
DG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwpRNDLQVGRFMIKMTNMDFIVQK---NIM
 |   |   | ||..    . . ||||| |.. |..||| |  . .|. |||.   ||  ..  . | |    . ...| . ..... . ..     ...
pgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlv

RRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVetYELMEMVKKSE------KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEH
 . .|. .   .   .. ..|.|..| . |||.. .  ..|. ..|.|        |||||||.|.||.  .|  . | .|.... .... . |||.. .
iknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraq

RWNGVQTNSQLYWM
| . |||. | ...
RnflvqteEqYifl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1079-1204 1.4e-12 42.1 In-house 57-181 (297) alignment
Range on Protein: 1079-1204
Range on HMM: 57-181/297.0
GKRAPIHANWVPTPG--HPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFI-VQKNIMrRSF
 .|  | |..|  |   .. ..| .| |..|| .||| . .. .|  |||| .  |  ..    | |    . |. | ....         .. |.   .
terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.tel

KVADStgkFAARTLTHYQYSQWAERGVPK
..         | ..| |.  | . ||| 
qliyr...sesrvvrhvqflswpdhGvps

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1080-1276 3.1e-33 110.2 In-house 73-272 (305) alignment
Range on Protein: 1080-1276
Range on HMM: 73-272/305.0
KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVAD
..  | |..| .  . ...|..|.|.. | .||| . ... |..|||. . ||  |.  . | |   ... . |.|......      .. . | .|.. 
dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek..tasdyieRklkisi

STGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK----S-EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNS
  ..   ||...||  .| . |||..     .|.. |.|    . ..|..||||.|.||. .||  .    ..... .... | ||.| ..| . |||  
ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtld

QL
| 
qY

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1080-1277 8e-26 85.6 In-house 71-267 (315) alignment
Range on Protein: 1080-1277
Range on HMM: 71-267/315.0
KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRfmIKMTNMDFIVQKNIMRRSFKVAD
..  | |  ...  . . .||.| | .|. .||| | .|..|  ||||  | |  |   . | |    .  . |   ||.. ..   . . . | . . .
dsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGs..ikvellsleadtdgvarklvtrk

STgkfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQ
|    . ||.| .|. .| ..||.|      .|.  || .    | ...|||| |.||.  .|  .    |..   .... . .| | ..|   |||. .
se...esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteee

LY
  
ya

0044763 (Phosphotyrosine protein) phosphatases II 1081-1280 4.5e-20 67.5 In-house 18-164 (178) alignment
Range on Protein: 1081-1280
Range on HMM: 18-164/178.0
RAPIHANWVPtpghPHRFIATQSPinatcEDFWAMCMQYEVEHIVMVGRKVEYWkniHNDYLPMWP---Rndlqvgrfmikmtnmdfivqknimrrsfkv
  .|.|...     |. ..... |     .|....  .. . |||..   .|..   .....| ||                                  
sdyinaseil....pglylgslpp.....addlellkelgithivnlteelelg...flkcdpywpeeag..............................

adstgkfaartlTHYQYSQWAERGVPKSHVETYELMEMVK----KSEKPIVVHCSNGIGRSMAFIGTEYLARQveadpTIELTEALKHLHEHRWnGVQTN
             .|..  .   ||| .   ..|..|...    ....|..|||| |.||| ...   .. ..      . | ||.....|.|. .|.. 
............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnp

SQLYWMT
.||... 
gqlrqLy

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1082-1278 7.6e-32 105.7 In-house 85-281 (298) alignment
Range on Protein: 1082-1278
Range on HMM: 85-281/298.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPR-NDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADS
  | | .. .  . . ||||| |...| |||| | ...... |||.   .|  |   . |   ||  .  . |.. ... . .  .. ... | .||...
dYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhky...wPdegketygeitvsllske..efadlivrklkvskk

TGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS-----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQ
. .   |.. . ....|...|||. .    .|.. |..|     .||..|.||.|.||| .||  . .  .|... .... ...| | ..| . |||..|
kee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq

LYW
  .
Yvf

subfamily_Ptp69D_pd Subfamily Ptp69D 1082-1310 6.7e-31 102.5 In-house 77-303 (307) alignment
Range on Protein: 1082-1310
Range on HMM: 77-303/307.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWP-RNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADS
  | |... .  . ..||| | |..|| .||| | .. ||. |||.    |. ..  . |   ||  .  | |  ..|. . ..  ... ..|...|.  
dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY...Wpiedevqygdilvklvseek..hsdyiiReldvskk

TGK----FAARTLTHYQYSQWAERGVPKSHVETYELMEMV----KKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQT
  .     . | .. |.| .| .  ||..     .|.|.|    |... |||||||.| |||  |.  . |  |..|. .... |  |.|...|   || 
keesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

NSQLYWmtlgtMYRLIKEYGFDmKIYDQQMAMFNDVVK
  |  .     .|| . .|       |...  ..| ..
leqYvf.....lyralldyssy.gdtdedvddledaie

0043147 (Phosphotyrosine protein) phosphatases II 1082-1279 1.1e-30 102.0 In-house 6-153 (172) alignment
Range on Protein: 1082-1279
Range on HMM: 6-153/172.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKveywknihndylpmwprndlqvgrfmikmtnmdfivqknimrrsfkvaDST
  |.|...... .|.|||||| | . |..|||.|. .. . |||.. .                                                   .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................lyd

GKFAARTLTHYQYSQWAERGVPkSHVETYELMEMVKK-----SEKPIVVHCSNGIGRSMAFIGTEYLArqveadPTIELTEALKHLHEHRWNGVQTNSQL
...  |.  .|.|  |   ||| .    .|..| ...     ...|..|||| |.||. ...   ..         . | ||.... |.|...||. ||.
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

YWM
.. 
rfl

0046846 (Phosphotyrosine protein) phosphatases II 1082-1278 9.5e-24 79.5 In-house 13-164 (176) alignment
Range on Protein: 1082-1278
Range on HMM: 13-164/176.0
APIHANWVPTPghphRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLqvgrfmikmtnmdfivqknimrrsfkvadst
  |.||.. ..    |.|||| |.. |..||..|  .. ....|..   ||. .    .| | . ....                               
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

gkfaartltHYQYSQWAERGVPKShVETYELMEMVKKSE---KPIVVHCSNGIGRSMAFIGTEylarQVEADPTIELTEALKHLHEHRW-NGVQTNSQLY
         .|..  | . ||| .    .||.|....     .|..|||| ||||. ...        .| .  . . |||... |.|. . ||| .|..
.........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

W
.
f

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1082-1277 2.4e-21 70.7 In-house 71-283 (301) alignment
Range on Protein: 1082-1277
Range on HMM: 71-283/301.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTN----MDFIVQK---------
  | |...    . ..|||.|.|.. |  ||| . .|. . .||||  . |  |.  . | |    .. ..| | ....|     ||....         
eyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgs

--NIMRRSFKVADSTgkfAARTLTHYQYSQWAERGV---PKSHVETY--ELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKH
  . . |.|||  .    ...... .|  .| . ||   |.  ..     ..   | .  |.|||||....||  ..  .    |. |.  ... .  | 
nngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtka

LHEHRWNGVQTNSQLY
.   .   |.|  |  
vrrskpgaVtTLeqyt

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1083-1280 2.3e-34 113.9 In-house 76-272 (318) alignment
Range on Protein: 1083-1280
Range on HMM: 76-272/318.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWP-RNDLQVGRFMIKMTNmDFIVQKNIMrRSFKVADsT
 | ||...   . . .||.|.|.  |.|||| |  . .   |||. ...|  |.  . |   || ..  . |. ...... .. ... .. |.|||   |
yinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry...WPskgsrsygklvvelke.evelsdyvl.refkvtr.t

GKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQl
.. . |.   |.| .|...|||.| ..  .|.  |.| .     .||||||| |.||   ||  . | ....|. .... .  |.| |.|   |||..| 
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedq.

YWMT
| . 
yefi

subfamily_PTPN12_pd Subfamily PTPN12 1083-1277 1.3e-32 107.9 In-house 70-267 (290) alignment
Range on Protein: 1083-1277
Range on HMM: 70-267/290.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIvQKNIMRRSFKVADStg
 | ||..  .  ....||.|.|. .| .||| | ....|| .||. |.||  |.  . | |    ..|..| | ..... . . ..... |..||  .  
YinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav.dddflirtLkveaq..

kFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEAD---PTIELTEALKHLHEHRWNGVQTNSQ
  . |... ..| .| ..|||.|. .  ||.|.|..    ...|.||||| |.||  . |  .|  ....|.   ..... . . .| ..|   |||. |
.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq

LY
  
ye

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1083-1277 2.9e-29 96.9 In-house 78-273 (290) alignment
Range on Protein: 1083-1277
Range on HMM: 78-273/290.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDlqVGRFMIKMTNMDfIVQkNIMRRSFKVADSTG
 |.| ..    . ...||||.|.. |  ||| . .| .|  |||.   .|  |.  . | |  . ..  .| | ||..|   ... ....| ..| ... 
yinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllnee.tln.eyierklevknkns

KFAARTLTHYQYSQWAERG-VPKSHVETYELMEMVK----KSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
. |....|.|| . | . | |.. .  .  . ||.|    . ...||||||...|||  |. ..    ... .  |.. . ||..   . . |||. |. 
agakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq





subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1083-1276 7.8e-27 88.5 In-house 73-265 (515) alignment
Range on Protein: 1083-1276
Range on HMM: 73-265/515.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTG
 . |  .|.    . .||.| | .|. .||| . .|..|  |.|| .. |  |     | |  | . .. | . ...  ..     . ..| ..|  .  
yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsle..actggikrkltvlkgdd

kfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
   .||.| ... .| ..||||       |.  || .    . |...||| |.||   .|  .    ...   .... . .. . ..|   |||. | 
...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqy

0051082 (Phosphotyrosine protein) phosphatases II 1083-1278 4e-20 67.4 In-house 5-144 (151) alignment
Range on Protein: 1083-1278
Range on HMM: 5-144/151.0
PIHANWVPTPghphrFIATQSPinatCEDFWAMCMQYEVEHIVMVGRKVEYWknihnDYLPMWPRNDlqvgrfmikmtnmdfivqknimrrsfkvadstg
.|....|        ..... |     .||...  .. . .||..  ..|.       .   .|...                                 
yinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.....ycpeylpelg.................................

kfaaRTLTHYQYSQWAERGVPKSHVETYELMEMVKKS-EKPIVVHCSNGIGRSMAFIGTEYLARQveadptIELTEALKHLHEHRWNGVQTNSQLYW
    ....|...  | . |.| |  .  |..|.. .  ..|..|||| |.||. ....   ....      . | |||......|.. ||.| | . 
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

subfamily_PTPRD_pd Subfamily PTPRD 1084-1291 4.2e-39 129.6 In-house 79-280 (564) alignment
Range on Protein: 1084-1291
Range on HMM: 79-280/564.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWpRnDLQVGRFMIKMTNMDfiVQKNIMRRSFKVaDSTGK
| |... .  ... .|||| |.. |.|||| |....... |||. . .|  |.  ..| |   .   ..|........      .... |.||.   . .
INAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee..eladyeirtfkl.kkkks

FAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQlYWM
  .|. ..... .| ..|||.|  .  .|.. |...    ..|||||||.|.||. .||  ... ...... |... . .|.| ..|   |||..| |  
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQ.YiF

tlgtMYRLIKEY
    ... | |.
....iheailea

0051429 (Phosphotyrosine protein) phosphatases II 1084-1288 5.2e-33 110.2 In-house 7-226 (272) alignment
Range on Protein: 1084-1288
Range on HMM: 7-226/272.0
IHANWVPTPGH---PHRFIATQSPINATCEDFWAMcMQYEVEHIVMVGRK--------VEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMR
|.|..|...|.   |.|..... | ..|..|||..  .. . .||.. .           || .|.  .||.... . ..  ... .|.. .... ... 
iNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

RSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHveTYELMEMVKKsEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIE--------LTEALKHLHE
| . .    .  .||...|..| .|  .|||..     ||.|.. . ..|..|||| |..|.  ..   .|...|...  ..        | ||...| .
rellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelra

HRWNGVQTNSQLYWMTLGTMYRLI
.| . |||  |...     .  | 
qrpgavqteeqylflyeallellr

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1084-1293 1.7e-30 101.1 In-house 49-265 (290) alignment
Range on Protein: 1084-1293
Range on HMM: 49-265/290.0
IHANWVPTPgHPHRFIATQSPI-------NATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHN----DYLPMWPRNDLQVGRFMIKMTNMdfIVQKNIMR
|||| |  | .  |.|.||||        |.| |.|| | .| .|...||..   |  .| ..     | |.   ..|... . .| ...  . .... .
iHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCksk..ekeddvet

RSFKVAdsTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEyLARQVE--ADPTIELTEALKHLHEHRWNGV
|   |    ..    |.||.....| .. |....    .|...||.|. |..||| .|| || |.   . |. |        ..|...|| | ..| . .
Relvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.lgyQkiaetsgsvkledvlkalrkqralai

QTNSQLYWMTLGTMYRLIKEYGF
... .| ..  | . ..|...  
tsalelafvdagivllaievldq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1084-1281 9.2e-26 86.0 In-house 56-249 (284) alignment
Range on Protein: 1084-1281
Range on HMM: 56-249/284.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkveywKNIHNDYLPMwpRNDLQVGRFMIKMTNMDFIVQknIMRRSFKVADSTGK
| | ..    .....|||| | . | .||| |  .|..  ||..       |.   .| |   . . . .|| .|.. ..   .   . |...... . .
inasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl..kivikeerfkvkvdsveesee..yvvrdielsedgke

FAARTLTHYQYSQWAERGVPKSHVETYELMEMVK------KSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
   |... . .  | . |||.. ..   |.. |.      . ...|||||| |.||. ..|  . |  ... .  ... . .. | . | . ||   | .
kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

WMTL
..  
fiys

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1084-1278 2.8e-25 84.1 In-house 82-275 (297) alignment
Range on Protein: 1084-1278
Range on HMM: 82-275/297.0
IHANWVPtpGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIhNDYlpmWPRNDLQ-VGRFMIKMtnMDFIVQKNIMRRSFKVADSTG
. | .|.  |  ||.|.|| | .|| .||||| ....|  |||.  . |  |.    |   |. .  .  |   ...  .    ..  ..|...|. .  
vnasfvk..gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkc.ary...WsdkgvttfGdvsvvl..lsvsereGfikrelevtkgka

KfAARTLTHYQYSQWAERGVPK--SHVETYELMEMVKK-----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQ
| | | .  ||. .| .. |..  |     .|.. |.|     .| |..|||..|.||   ..  .    ... . .... . .|.| ..| . |||. |
k.arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

LYW
  .
ykf

0036282 (Phosphotyrosine protein) phosphatases II 1084-1278 2e-24 81.6 In-house 5-161 (174) alignment
Range on Protein: 1084-1278
Range on HMM: 5-161/174.0
IHANWVPTPGHPHRFIATQSPINatcedFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwprndlqvgrfmikmtnmdfivqknimrrsfkvadsTGK
|.|...     . |.||.| | .     ||.|. .. ....||. . .|  .    .| |.                                    . .
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lre

FAARTLTHYQYSQWAERGVPKSHVeTYELMEMVKKS-----EKPIVVHCSNGIGRSMAFIGTEYLARQVEaDPTIELTEALKHLHEHRWNGVQTNSQLYW
.  |.  .|.|  |  .||| ...  .|... |..      ..|..|||| |.||. ....  .. |. .  ....  . .. |. .| ..||| ||...
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf





subfamily_CG7180_pd Subfamily CG7180 1084-1275 3.1e-21 70.3 In-house 73-278 (296) alignment
Range on Protein: 1084-1275
Range on HMM: 73-278/296.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKnIHNDYLPMWPrnDLQVGRFMIKMTNMDFIvqKNIMRRSFKVADS---
| | .| .  ... .| |. | . | ..|| .  . |.. .|.. .. .. |   ..|.|       | | .........     |.  | ||.      
inavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqy..anlkirtfkltkkiva

------TGKFAARTLTHYQYSQWAE-RGVPKSHVETYELMEMVK----K-----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHE
        |   |.....|. .|     || |     ||...|.    |      |.|.||..|.| .|| .... .    .|| .  ... ||.| | .
lteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrr

HRWNGVQTNSQ
.| . |..  .
sRpqLvenvee

subfamily_ptpA1_pd Subfamily ptpA1 1084-1241 1e-11 39.2 In-house 78-250 (418) alignment
Range on Protein: 1084-1241
Range on HMM: 78-250/418.0
IHANWVPTpGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVE--------YWK-NIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMRRS
| ||..    .|..||.|| |.  |  ||| |  .  .  |||. |. |        ||  .|  . . ..   .  .| . ... ..    ...|. | 
inanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrn

FKVadsTGKFAARTLTHYQYSQWAERGVPKSHVETYELME--------MVKKSE--KPIVVHCSNGIGRSMAFIGTE
 ..   | .  .| .|.|||  | .. .|       .|.         ..  |.   ||.|||| |.||. .|  . 
irl...tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1084-1203 1.9e-06 21.7 In-house 125-237 (244) alignment
Range on Protein: 1084-1203
Range on HMM: 125-237/244.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRkVEYWKNIHNDYLPM-WPRNDLQVgrfmiKMTNMDfiVQKNIMRRSFKVaDSTG
| | .|   |    .| || |.  |  ||| | ..  |. .|..|  ||   .   |  |. |  .|. |      .|. |    |||    ... .|  
inasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veeedeywpdseplewyeeditv.....tltdrd..efknikasnlei.esdm

KFAARTLTHYQYSQWAERGV-P
. . ..|| .| |.|   |  |
neshqaltmfqisnwpsdgttp

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1084-1201 2.8e-06 21.7 In-house 16-125 (130) alignment
Range on Protein: 1084-1201
Range on HMM: 16-125/130.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRkVEYWKNIHNDYLPM-WPRNDLQVGrfMIKMTNMdfivqKNIMRRSFKVADSTg
|.|..|   |.   .. || |. .|. ||| | ..  |. .|..|  ||   .   |  |. |  .|. |   . .  ..     |||    ... .   
inasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeedeywpdsePlewyeediivt..ltdrdef.....knikasnleiesdl.

KFAARTLTHYQYSQWAERG
. . ..|| .| |.|   |
neshqaltmfqisnwpsdg

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1085-1276 3e-25 83.7 In-house 61-255 (283) alignment
Range on Protein: 1085-1276
Range on HMM: 61-255/283.0
HANWVP---TPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwpRNDLQVGRFMIKMTNMdfIVQKNIMRRSFKVADST
 | ..|      . ...|..|||.. |  ||| |  . ..  |||. .  |  .     | |   |   . | | . . .     ..  ... . .  ..
navfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rGsedyGeftvtlrke..ttsnsfiikelllrvns

GKFAARTLTHYQYSQWAERGvPKSHVETY---ELM-EMV-KKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
   ..  |.|||. .| | | ... ...    ...     .. . |||||||.||||. .||.      .. ..  ... . .| . |.|   |||  | 
sakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqy





subfamily_PTPRA_pd Subfamily PTPRA 1087-1291 4.2e-25 83.3 In-house 92-294 (330) alignment
Range on Protein: 1087-1291
Range on HMM: 92-294/330.0
NWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRND-LQVGRFMIKMTNMDFIVQKNImrRSFKV---ADSTG
 ..    . ..|||.| | . | |||| |  ...   |||.    |  ..  . |   || .  .  |   ... ..  .|.  .  | | |   .|.| 
sfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy...wPdeGlvtyGnirvevedetvlvdytv..rkflvqqlpdatr

KFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
. ..| .. . .  | . |||   .   .|.. ||| .     ||||||| |.||. .||  . .  .|.|.  ... |..|.|   | . |||. |  .
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef

mtlgtMYRLIKEY
     .|. ..||
.....iykvlley

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1088-1278 6.8e-30 99.1 In-house 44-233 (250) alignment
Range on Protein: 1088-1278
Range on HMM: 44-233/250.0
WVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNiHNDYLPMwpRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTgKFAAR
.. .    . |||||.|..|| |||| | ...... |||.   .|  |.  ..|.|.   .  . |  .... . .  .  ... | .|..  . |   |
flhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..ekaekyGdvtvsllske..efadytkrklklskak.kader

TLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
.. .... .| ..|||.      ||.. |..|.     .|..|.||.|.||| |||  . .  ... . .... . .| | ..| . |....|  .
ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf

0049260 (Phosphotyrosine protein) phosphatases II 1091-1279 7e-27 89.4 In-house 4-142 (152) alignment
Range on Protein: 1091-1279
Range on HMM: 4-142/152.0
TPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLpmwprndlqvgrfmikmtnmdfivqknimrrsfkvadstgkfaartlt
  ..|..||||| | . |..||| |  .. . .|||. . .| .|  .. |                                                 
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................

HYQYSQWAERGVPKSHVETYELMEMV----KKSEKPIVVHCSNGIGRSMAFIGTEYLArqveadPTIELTEALKHLHEHRWNGVQTNSQLYWM
.|.. .|   |||...   ..|....    .....|..|||| |.||. ...   ..         ..| ||.... |.|...|.. .||.. 
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

subfamily_PTPN23_pd Subfamily PTPN23 1091-1277 1.4e-26 87.9 In-house 79-270 (288) alignment
Range on Protein: 1091-1277
Range on HMM: 79-270/288.0
TPGHPhRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRfmIKMTNMDFIVQKNIMRRSFKVADsTGKFAARTLT
.|| |  |||||.|.. |  ||| | ..  .. |||.  | |  |.  . | |    .  . |   ...|  .    .. ..| .|.    .. | ....
spgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..lsvtlksvretethvervlklet.ldadavksvs

HYQYSQWAERGVPKSHVETYELMEMVKK--------SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTI-ELTEALKHLHEHRWNGVQTNSQLY
| |. .|.| |||.|  .  .... |..        |..|.||||| |.||. .|      .|..|... . .. . ...| | | . ||...|| 
hlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1092-1278 1.4e-20 68.5 In-house 41-230 (237) alignment
Range on Protein: 1092-1278
Range on HMM: 41-230/237.0
PGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRnDLQVGRFMIKMTNMDFIVQknIMRRSFKVADSTGKFAARTLTH
 | |...||.| |....|.||| |  |     |||.   .|  .    .| |   .     | . . ..  . . .     ||. ..  . .   | .  
dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paaygvltvslkkkeefsd..ytvrslllskrltlkevrlihq

YQYSQWAERGVPKSHVETYELM-EMVKKSEK-----PIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
||.. | .||||.       .  .....|..     | ..||| |.||.  |.  . . || .    ... . .. . | |   .||. |  .
yqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvf

subfamily_PTPN14_pd Subfamily PTPN14 1093-1276 5.4e-23 76.4 In-house 90-285 (300) alignment
Range on Protein: 1093-1276
Range on HMM: 90-285/300.0
GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMW--PRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKfAARTLT
|. . .|..|.|.. |..||| |  . .|. |||. .. |  |.    |.|     .. .. |.| .     .    . .. ...|.     |   ||. 
gkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfse..dsdsvittglklkhlpsk.eertvw

HYQYSQWAERGVPKSHVETYELMEMVK-------------KSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
| ||  |...|||.   .  . .|.|.             .|. |..||||.|.||.   | .. |   .| . .|.. ..|..| | |   ||| .| 
hlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqY

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1093-1281 5.7e-20 66.5 In-house 49-235 (239) alignment
Range on Protein: 1093-1281
Range on HMM: 49-235/239.0
GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFkVADSTGKFAARTLTHY
| |. .||||  ..... ||| |  |     |||.   .|  |.   .|   || .  .   . . . . .  |  . . |.| |    |.   | . .|
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy...wpdstskycnlrvtlrkte..vfadyiirtf.vmsqvgqteeryvyqy

QYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTL
... | ..|||.       |   . |      .| |.||| |.||. ||.  . . || . . |... . .| ..| |   |||. |  .. |
hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1093-1281 5.7e-20 66.5 In-house 48-234 (239) alignment
Range on Protein: 1093-1281
Range on HMM: 48-234/239.0
GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFkVADSTGKFAARTLTHY
| |. .||||  ..... ||| |  |     |||.   .|  |.   .|   || .  .   . . . . .  |  . . |.| |    |.   | . .|
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy...wpdstskycnlrvtlrkte..vfadyiirtf.vmsqvgqteeryvyqy

QYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTL
... | ..|||.       |   . |      .| |.||| |.||. ||.  . . || . . |... . .| ..| |   |||. |  .. |
hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1096-1266 4.5e-16 53.6 In-house 4-182 (198) alignment
Range on Protein: 1096-1266
Range on HMM: 4-182/198.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkvEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNI--MRRSFKVADSTGKFAARTLTHYQ
.|.|||| |.  |  ||| |  .    |||||    .  ||   ||  .||  .  .|..         |. |    .     . ..|   ..| ..|||
rryiatqhplretladfwqmvwetgsghivmvn...ddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YSQWAERGVPKSHVETY---ELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT--IELTEALKHLHEHR
.. | |.  |.  .         |. || |     |..||||.| | .  |.  .   |  |   |  ..| |  | | . |
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1096-1266 4.9e-16 53.5 In-house 5-183 (199) alignment
Range on Protein: 1096-1266
Range on HMM: 5-183/199.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkvEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNI--MRRSFKVADSTGKFAARTLTHYQ
.|.|||| |.  |  ||| |  .    |||||    .  ||   ||  .||  .  .|..         |. |    .     . ..|   ..| ..|||
rryiatqhplretmadfwqmvwetgsghivmvn...ddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YSQWAERGVPKSHVETY---ELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT--IELTEALKHLHEHR
.. | |.  |.  .         |. || |     |..||||.| | .  |.  .   |  |   |  ..| |  | | . |
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1096-1162 3.9e-09 30.7 In-house 104-165 (350) alignment
Range on Protein: 1096-1162
Range on HMM: 104-165/350.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRndLQVGRFMIKMTNM
...||||.|.  | .||. .... .|. |...  .||.  .  . |   |..  ...  . .|....
fkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY...Wqe..gsydditvklask

subfamily_eak_pd Subfamily eak 1096-1231 2.2e-08 27.9 In-house 93-222 (332) alignment
Range on Protein: 1096-1231
Range on HMM: 93-222/332.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIkmTNMDFIVQKNIMRRSFKVadSTGKFAaRTLTHYQYS
...| |  . .     || | ..     ||..  .||   . .. |.|   |. |. | . .  .  .|. ....  | ...  | |  .   . ||.. 
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv..erkefvkrniletrllel..skGnet.hrvlhykvf

QWAERGVPKSHvETYELMEMVKKSEKPIVVHCSNGI
 |.|  .|| . .   | ...|.   . ..   . .
Gwtettlpkye.dflalrkvmkevGvlllivmksal

subfamily_PTPRN_pd Subfamily PTPRN 1097-1277 7.7e-19 62.5 In-house 101-282 (297) alignment
Range on Protein: 1097-1277
Range on HMM: 101-282/297.0
RFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGR-FMIKMTnMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYS
 .||||.|...|  ||| |  .  |  ||.. |  |   .  . |   || .  .|   . ...   . |  .. . ||| . .   .  .||.| . . 
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry...wpdeGsevyhiyevhlv.sehiwcddylvrsfylknlqts.etrtvtqfhfl

QWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYL-ARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
 | |.||| |     |.   | ||      |||||||.| ||. ..|  . . .| .     |... .|.|| . | . |.|..|. 
swpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1103-1283 2.4e-16 54.1 In-house 98-284 (302) alignment
Range on Protein: 1103-1283
Range on HMM: 98-284/302.0
SPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMRRSFKVA------DSTGKFAARTLTHYQYSQ
 | . |.| .||.  ||.|  .| .   ||  ..   .|     .. |. ||. .|  ...  ...   ..|||.       . . |   .|.   ..| 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTLGT
| . | ||    . ...   .   | ..||||.|.||. ...   |       . . .| . .. . . |.  ||...|| .. |  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1106-1276 5.5e-22 73.1 In-house 38-210 (255) alignment
Range on Protein: 1106-1276
Range on HMM: 38-210/255.0
NATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNmdfiVQKNIMRRSFKVADSTG-KFAARTLTHYQYSQWAERGVPK
  | . |. . .| . | .||..   |  ..  . |.|.   . |..    .  |.       ... |  ..    | |  ..|..||.|  | |.  |.
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

SHVETYELMEMVKKSeKPIVVHCSNGIGRSMAFIGTEYLAR----QVEADPTIEL--TEALKHLHEHRWNGVQTNSQL
   |  ... .|..| |..|||||.||||| ||. .|.. .    ...  .|.||   . |..| ..|   ..|  ||
lareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql

subfamily_hpo-7_pd Subfamily hpo-7 1107-1276 3.3e-19 63.8 In-house 45-216 (263) alignment
Range on Protein: 1107-1276
Range on HMM: 45-216/263.0
ATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFivqkNIMRRSFKVADSTG-KFAARTLTHYQYSQWAERGVPKS
 | . |. .  | . | .||..   |  ..  . |.|.   . ...    .  |..      ... .. ..    | |   .|..||.|  | |.  |. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpel

HVETYELMEMVKKSeKPIVVHCSNGIGRSMAFIGTEYLAR----QVEADPTIEL--TEALKHLHEHRWNGVQTNSQL
  | .........| |..|||||.||||| ||  .| . .    ...  .|.||   . |..| ..|   ..|  ||
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqL

0048076 (Phosphotyrosine protein) phosphatases II 1161-1280 3.7e-16 54.6 In-house 21-136 (145) alignment
Range on Protein: 1161-1280
Range on HMM: 21-136/145.0
NMDFIVQKNIMR-RSFkvaDSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMV---KKSEKPIVVHCSNGIGRSMAFIGTeYLARQveadPTIELT
..... . .| .  ..    |. ..  |. ..|.|  |  .||| ..   .|..|..    |...|..|||| |.||. ....  || ..      . | 
dlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll....lgvsle

EALKHLHEHRWNGVQTNSQLYWMT
|||......|...|.. .||... 
ealelvrsqrpgavpnpgqlrfly

0048179 (Phosphotyrosine protein) phosphatases II 1177-1279 4.7e-15 51.1 In-house 37-137 (144) alignment
Range on Protein: 1177-1279
Range on HMM: 37-137/144.0
VADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS---EKPIVVHCSNGIGRSMAFIGTEYLArqveaDPTIELTEALKHLHEHRWNGVQTN
. .    |  |. ..|..  |  .||| .    .|..|....    ..|..|||| |.||. ...    .         . | |||......|...|.. 
teeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp

SQLYWM
.||...
gqlrfL

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1184-1280 3e-09 30.7 In-house 86-187 (440) alignment
Range on Protein: 1184-1280
Range on HMM: 86-187/440.0
FAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS-----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
  .||| .|.|  | ..||||      .... |..|     . |..|||| | ||.   |  . . |...    |..   .. ... | . |||  |  .
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

MT
. 
vh

PTPc_DSPc_SM00012 1189-1276 2.6e-19 64.7 In-house 2-96 (105) alignment
Range on Protein: 1189-1276
Range on HMM: 2-96/105.0
LTHYQYSQWAERGVPKSHVETYELMEMVKKSEK------PIVVHCSNGIGRSMAFIGTEYLARQVEAD-PTIELTEALKHLHEHRWNGVQTNSQL
..||.|..| . |||..  .  ||.. |||...      |.|||||.|.||.  |.  ..| .|.|.   .... . .|.| ..| . |||. | 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy

PTPc_motif_SM00404 1191-1274 8.8e-07 23.9 In-house 51-128 (140) alignment
Range on Protein: 1191-1274
Range on HMM: 51-128/140.0
HYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQveadpTIELTEALKHLHEHRwNGVQTNS
... ..  .  . |   .... .| ..|... ..|||  |. || ..|  ... ..      ..| ||.. ..| | . .. | 
qiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr.....qlslaeayefvkerR.piispnl

subfamily_CG42327_pd Subfamily CG42327 1217-1278 2.2e-06 21.6 In-house 244-306 (319) alignment
Range on Protein: 1217-1278
Range on HMM: 244-306/319.0
KKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEAD-PTIELTEALKHLHEHRWNGVQTNSQLYW
..|  |.|||||.|.||.   | ..   |..|    .... . . .. . | . |.|  |  .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef