Gene Y48G1C.5 in Caenorhabditis elegans

Synonym: CELE_Y48G1C.5, Y48G1C.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily hpo-7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP218_AA protein Get Run
CeleP218_AA_913-1124 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
WSN Domain of unknown function 46-112 1e-19 60.2 Pfam-A 1-68 (69) alignment 
Range on Protein: 46-112
Range on HMM: 1-68/69.0
DNLITAVERLQFASRLINAMYLQQELTKGTIPSMNLTLDLFKYDF-SMDQLNAIDYSSLESKLIALKE
..| |..|.|.. .|..|..|||..|..|.||....  .|....  |..||..|| ..|..||..|.|
selqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_hpo-7_pd Subfamily hpo-7 198-270 4.8e-15 50.2 In-house 100-168 (263) alignment 
Range on Protein: 198-270
Range on HMM: 100-168/263.0
ALNDLLKKSQDFLNIVENpKITLHGFKNNnsaasFFVLWPKVRDVMNFISSFKIVDINRGLRKLEEHMAS--IRN
. .|.|.|....|..... |...|..|..     ....|....|.........|....|....|..|...   | 
vqsdvllktlellstlge.Kkkthtvkhy.....sykgWiekndpelareilnilkvarnskslvvhcstGiGrs
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 911-1122 3.9e-38 126.2 In-house 53-259 (290) alignment 
Range on Protein: 911-1122
Range on HMM: 53-259/290.0
VVELDNGLKFVLMPAPQLPV-DKKSSdilAIAAFWESVKLNKPSTIVMLCDFAEIDHFIGAnKvNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQ
 |   |||...|. .||  .  |. |    |  ||  .|  |   .||||.| | ..  .  . .| .|.|.. .|.| . .||. |.. . .  ..||.
rvtcpnglrliltqsPqekitekrnS...tiekfwwmakqEkvkqvVmlcefeeksantsl.f.aCakYvpesvgeelkfkgltvkCkskekeddvetRe

LLLTFGKKRTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTsETGEINYRSLIEQTRSKRKCAAPDPI
|...|....   |||... || .   ..|   .  |.. |  |. || | |  |  ||||.  |.  .| |    .|... ...... |..|  |  ...
lvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiae.tsgsvkledvlkalrkqralaitsal

YLAFAFYTTLTLF
 |||. .  . |.
elafvdagivlla
0040438 (Phosphotyrosine protein) phosphatases II 914-1122 5.9e-36 119.7 In-house 82-276 (317) alignment 
Range on Protein: 914-1122
Range on HMM: 82-276/317.0
LDNGLKFVLMPAPQlpvdkKSsdilAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLT
 . . ||... .|.     ..     .. ||. |. .. ..||||... |       ....|..|.|.  .|.|   |.|.|... . ..  . |.| ..
pnlkrkfIatqgPl.....pn....tvedFwrmvweqgvtvivmLtelee......lgrekcaqYwpl..getltygdftvtllseeelagitlrtleve

F-GKKRTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTDS----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRKCAAPDP
  |.. . .|||..|||||.|  |.. ...  .|..| ..    . || | |. | ||...|.... ... ... .  .... . ... |..| .| . |
dlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtp

IYLAFAFYTTLTLF
 .. |  .  | ..
eqyrflydalleyl
0044763 (Phosphotyrosine protein) phosphatases II 914-1113 6.3e-14 47.5 In-house 26-162 (178) alignment 
Range on Protein: 914-1113
Range on HMM: 26-162/178.0
LDNGlkFVLMPAPQlpvdkkssdilaiAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDekliladltitctksiskpllktrqlllt
 ..|  . |...|.             |...| .| .. ..||.|..  |        ...||.|.|.| .                             
ilpg..lylgslpp.............addlellkelgithivnlteelelg......flkcdpywpeeag.............................

fgkkrtqevTHYQYTGWPEHMGPKDAEEIRYLLKLVT----DSERPVFVVCNTGGGRSAAFVLIESLFQAintsetgEINYRSLIEQTRSKRKcAAPDPI
          .|.....| |  |   | .. .....     ....||.| |. | |||...|..  . .         ... . ||. |..|  . | | 
.........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.......glsleeaielvrerRp.ivpnpg

YLAF
.| .
qlrq
0045450 (Phosphotyrosine protein) phosphatases II 915-1122 4.4e-34 114.0 In-house 104-304 (307) alignment 
Range on Protein: 915-1122
Range on HMM: 104-304/307.0
DNGLKFVLMPAPQLPvdkkssdilAIAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTElDEKLILADLTITCTKSISKPLLKTRQLLLTF
|...||... .|.            .. ||. .. .. ..||||... |       ... |..|.|.| .|.|   ..|.|...   .. .. |.| .| 
dlkrkfIatqgPlpe.........tvedFwrmlweqgvtvivmltelvel......grekcaqywPde.geeltygnftvtllseehldgytvrtlevtd

--GKKRTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTD------SERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGE-INYRSLIEQTRSKRKCAA
  |.. . .|||..|||||.|  |.. ||.  ....| .      .. || | |. | ||...|...  . . ... .| . ..... ... |..| .| 
ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

PDPIYLAFAFYTTLTLF
. | .. |  .  | |.
qnpeqyrflyeallell
subfamily_hpo-7_pd Subfamily hpo-7 917-1149 3.5e-90 296.5 In-house 8-256 (263) alignment 
Range on Protein: 917-1149
Range on HMM: 8-256/263.0
GLKFVLMP-------------APQLPVDKKSSDIL---AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSI
.|||...|             .|......|....|   .|..|.......|....||||||.|      .....|..|||.|.|||..||......||..
alkfgklPrilidedvctehfkPekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfne......egvekcssyfPlekdekqklanvnvcttkvq

SKPLLKTRQLLLTFG-KKRTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTDSeRPVFVVCNTGGGRSAAFVLIESLFQ----AINTSETGEINYRSLIE
|..||||..|| |.| ||.|..|.||.|.||.|...|..|.||...||....| ....|.|.||.||||||...|...|    ...|..|.|..|.||.|
sdvllktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLle

QTRSKRKCAAPDPIYLAFAFYTTLTLFYPANAHDDAY--VTQICRMYFDANEGLKK
..||.||.|...|..|||.....|.......|.....    .| . |. | . ..|
elrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeirksylharqmmhk
0040439 (Phosphotyrosine protein) phosphatases II 918-1121 9e-32 106.0 In-house 54-245 (249) alignment 
Range on Protein: 918-1121
Range on HMM: 54-245/249.0
LKFVLMPAPQLPvdkkssdilAIAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLTF-GK
 .|... .|            ....||. .. .. ..||||... |       ....|..|.|.  .. |   |.|.|... ..|. ...|.| ||. ..
rrfiatqgPlpe.........tvedfwrmlwelgitvivmLtslvel......grekcaqywpl..ggsleygdftvtllsvevkddytvrtleltnlyd

KRTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTD------SERPVFVVCNTGGGRSAAFVLIESLFQAINtsETGEINYRSLIEQTRSKRKCAAPDPIY
. . .|.|.|||.||.|  |.. |..  ....| .      .. ||.| |. | ||...|...  ... ..  ....... . ... ||.| .| . | .
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqle..kelgvdleeavkllrsqRpgavqnpeq

LAFAFYTTLTL
. |  .  | |
yrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 919-1119 8.2e-33 109.5 In-house 89-274 (278) alignment 
Range on Protein: 919-1119
Range on HMM: 89-274/278.0
KFVLMPAPQLPvdkkssdilAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPtelDEKLILADLTITCTKSISKPLLKTRQLLLTF-GKK
||... .|.            .. ||. |. .. .|||||... |       ..|.|..|.|   .. |   |.|.|..| ....  ..|.| .|  |..
kfiatqgPlpe.........tvedFwrmvwelgvttivmLtelve......lgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdg

RTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTD----SERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRKCAAPDPIYLAF
 ...||||.|.|||.|  | . . .  .|| | .    |. || | |. | ||...|.... |.. ...    .... . ... |..| .| . | .. |
esrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrf

AFYTTL
 ..  |
lyeall
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 925-1149 1.1e-97 321.1 In-house 26-247 (255) alignment 
Range on Protein: 925-1149
Range on HMM: 26-247/255.0
APQLPVDKKSSDILAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFG-KKRTQEVT
.|. ....|....|....|.......|....||||||||      .....|..|||.|.||||.|||...|.|||.....|.|.....|.| ||.|..|.
kPekdkkrknlysltvdkfyqtivqtktevvvmlcdfae......egvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvk

HYQYTGWPEHMGPKDAEEIRYLLKLVTDSeRPVFVVCNTGGGRSAAFVLIESLFQ----AINTSETGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTL
||.|.||.|...|..|.||...||.|.|| ..|.|.|.||.||||||||.|...|    ...|.||.|..|.||.|..|||||.|...|..|||.....|
hysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

TLFYPANAHDDAYVtQICRMYFDANEGLKK
.|..|.......|. .| . |. | . ..|
dlvfpkgeleakyq.eirksylharqmmhk
0039614 (Phosphotyrosine protein) phosphatases II 927-1120 1.5e-32 108.7 In-house 107-287 (297) alignment 
Range on Protein: 927-1120
Range on HMM: 107-287/297.0
QLPVDKkssdilAIAAFWESVKLNKPSTIVMLCDFAEIDhfiganKvNCDRYFPTELDeklILADLTITCTKSISKPLLKTRQLLLTFgKKRTQEVTHYQ
| | ..       .. ||. |. .. ..||||... | .      .  |..|.|.| .      |.|.|..| . ..  ..|.| .|  .. . .|||.|
qgPlpe......tvedFwrmvweqgvtvivmLtklvelg......r.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfq

YTGWPEHMGPKDAEEIRYLLKLVTD------SERPVFVVCNTGGGRSAAFVLIESLFQAINTSetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTLT
|||||.|  | ..| .  .|.|| .      ...|| | |. | ||...|...  ... ...   |.... . ... |..| .| . | .. | ..  | 
ytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydalle
0037934 (Phosphotyrosine protein) phosphatases II 927-1119 1.9e-25 85.3 In-house 50-239 (243) alignment 
Range on Protein: 927-1119
Range on HMM: 50-239/243.0
QLPVDKKSSDilAIAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPtelDEKlILADLTITCTKSISKPLLKTRQLLLTF--GKKRTQEVTH
|.| ..   |  . |.||. .. .. ..||||... |       ....|..|.|   .|.    |.|.|.... ...  . | |||.    .. |..|.|
qgPlpetved..dlasfwrmlwelgitvivmltelvEl......grekcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvih

YQYTGWPEHMGPKDAEEIRYLLKLVT------------DSERPVFVVCNTGGGRSAAFVLIESLFQAIntsetgEINYRSLIEQTRSKRKC-AAPDPIYL
|.|..||.|  | . | .  .|. |.            ||..|| | |  | ||.......  . . .      .... . ... |..| . | . | ..
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqy

AFAFYTTL
 |  .  |
rflyeall
0046845 (Phosphotyrosine protein) phosphatases II 932-1121 1.1e-32 108.9 In-house 88-273 (284) alignment 
Range on Protein: 932-1121
Range on HMM: 88-273/284.0
KkssdilAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTElDEKLILADLTITCTKSISKPLLKTRQLLLTFG--KKRTQEVTHYQYTG
.       .. ||  |  .. ..||||... |       ... |..|.|.| .|.|.. |.|.|...   |.  ..| | ||.   .. . .|||..||.
n......tvedFwrmvweqnvrvIVmltelve......ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyts

WPEHMGPKDAEEIRYLLKLVTDS------ERPVFVVCNTGGGRSAAFVLIESLFQAINTSE-TGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTLTL
||.|  | ..| .  .|.|| ..      . |. | |  | ||...|.... |.. ... . . .... ... . |..| ..   .  . | ... | .
wpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley
0042113 (Phosphotyrosine protein) phosphatases II 932-1119 5e-30 100.1 In-house 63-240 (245) alignment 
Range on Protein: 932-1119
Range on HMM: 63-240/245.0
KkssdilAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLTF-GKKRTQEVTHYQYTGW
.       ...||. .. .. .|||||... |       ..|.|..|.|.  .|.|   |.|.|...  ... ...|.| .|  |.. ..||.||.|..|
e......tvedfwrmlwelgittivmLteeee......lgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

PEHMGPKDAEEIRYLLKLVTD-----SERPVFVVCNTGGGRSAAFVLIESLFQAINTSetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTL
|.|  | . | .  .|..| .     |. ||.| |. | ||...|...  ... ...   ....  . ... ||.| .| . | .. |  .  |
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeall
0050432 (Phosphotyrosine protein) phosphatases II 936-1120 1.5e-34 115.1 In-house 119-297 (308) alignment 
Range on Protein: 936-1120
Range on HMM: 119-297/308.0
DilAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELD-EKLILADLTITCTKSISKPLLKTRQLLLTF-GKKRTQEVTHYQYTGWPEH
.   .. ||  |  .. ..||||... |       ....|..|.|.||. . |.  ..|.|...  ...  ..|.| ||. |.. . .|||..||.||.|
n..tvedFwrmvweqnvrvIvmLtklve......ngrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdh

MGPKDAEEIRYLLKLVTDS--ERPVFVVCNTGGGRSAAFVLIESLFQAINTSetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTLT
  | ..|..  .|.|| .|  . |. | |. | ||...|.... |.. ...   |.... ... . |..| .. ..| .. | ... | 
gvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralle
0036282 (Phosphotyrosine protein) phosphatases II 936-1114 2e-14 49.1 In-house 27-162 (174) alignment 
Range on Protein: 936-1114
Range on HMM: 27-162/174.0
DilaiaaFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTeldekliladltitctksiskpllktrqllltFGKKRTQEVTHYQYTGWPEHMG
.      ||| .| .. .|.|||..  |       ... | .|.|.                                . .  .... .|.|..|| |  
a......fwemlkelgittvvmlleeke......lglykcinywpe................................lredlerlgiqylylpwpDhgv

PKDAEeIRYLLKLVTDS-----ERPVFVVCNTGGGRSAAFVLIESLFQAINtseTGEINYRSLIEQTRSKRKCAAPDPIYLAFA
| ... .. ..|.| .      ..|| | |. | ||....|..  . . .    .. ..  .|. . |..| .. . | .. | 
pdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvrelRlqrpgmvqtpsQyrfl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 936-1101 1.2e-07 25.5 In-house 97-215 (392) alignment 
Range on Protein: 936-1101
Range on HMM: 97-215/392.0
DILAIAAFWESVKLNKPSTIVMLCDFAEIDhfigankvncdryfpteldekliladltitctksiskpllktrqllltfGKKRTQEVTHYQYTGWPEHMG
 . ..  ||. |  ....||.|. .. | |                                                   . .. |. ...| ||..  
naaslddfwrmvfqenvttiamvtklkegd.................................................kgddartvaqfhftewPdkdv

PKDAEEIRYLLKLVTD----SERPVFVVCNTGGGRSAAFVLIESLFQAINTseTGEINYRSLIEQTRSKR
|| .  .  ..| |        .|. . |..| ||..  . |.|.    ..  |  ..   .. . | ||
pkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakk..trmvdvfnfvtnirrkr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 938-1102 2.1e-14 48.2 In-house 103-259 (315) alignment 
Range on Protein: 938-1102
Range on HMM: 103-259/315.0
LAIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPtelDEKLILADLTITCTKSISKPLLKTRQLLLTFGkKRTQEVTHYQYTGWPEHMGPK
 ..  ||  |  .. ..|||| . .|       .| ....|.|   |.|.|   .|.|  .   .  .  | |  .|| .. .||  ..|| ||.   ||
asvkdfwrlvfeedigkivmltnlve......gekrkaekywp...dkkviyGkitvtrkseevnteytvrtlsvvfg.dnirevvqlhytswpdmgvpk

DAEEI----RYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
 .  .    |   .  |.|  .. | |. | ||. .|. ...... ... .   |.   .|.. |..|.
ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaena..idvynfitgvrqnri
0036941 (Phosphotyrosine protein) phosphatases II 939-1122 6.4e-37 122.9 In-house 90-277 (297) alignment 
Range on Protein: 939-1122
Range on HMM: 90-277/297.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSIS--KPLLKTRQLLLTF-GKKRTQEVTHYQYTGWPEHMG
 .. ||  |  .. ..||||... |       ....|..|.|.| .| |   |.|.|...  .  ..  ..|.| .|. |.. . .|||..|||||.|  
tvedFWrmvweqnvtvIvmltelve......lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgv

PKDAEEIRYLLKLVTD------SERPVFVVCNTGGGRSAAFVLIESLFQAINTS-ETGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTLTLF
| .....  ...|| .      |. || | |. | |||..|.... ..| .... ..|.... ... . |..| .| . .  . |  .. | |.
pespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 939-1119 1.6e-33 111.7 In-house 89-269 (273) alignment 
Range on Protein: 939-1119
Range on HMM: 89-269/273.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDE-KLILADLTITCTKSISKPLLKTRQLLLTF-GKKRTQEVTHYQYTGWPEHMGP
 .. ||  |. .. ..||||... |       ....|..|.|.| .| .|.  ..|.|...  .|.  ..|.| ||. | . . .|||..|||||.|  |
tvedfwrmvweqnvrviVmLtelve......lgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvp

KDAEEIRYLLKLVTD------SERPVFVVCNTGGGRSAAFVLIESLFQAINTSetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTL
 . |..  ...|| .      |. || | |. | ||...|.... |.. ...   |.... ... . ||.| .. . | .. |  .. |
pslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyeall
0051299 (Phosphotyrosine protein) phosphatases II 939-1119 9.6e-33 109.3 In-house 104-283 (288) alignment 
Range on Protein: 939-1119
Range on HMM: 104-283/288.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLTF-----GKKRTQEVTHYQYTGWPEH
 .. ||  |  .. ..||||... |       ....|..|.|.  ...|.. |.|.|...  ...  ..|.| .|      |.. ...|||..||.||.|
tvedFWrmvweqnvrvIvmltklve......lgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

MGPKDAEEIRYLLKLVTDS----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTL
  | ..|..  .|.|| ..    . || | |. | ||...|.... |.. ...   |.... ..... |..| .. . |  . | ... |
gvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyeall
DSPc_SM00195 939-1117 1.6e-32 108.3 In-house 81-257 (263) alignment 
Range on Protein: 939-1117
Range on HMM: 81-257/263.0
AIAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCTKSISKP-LLKTRQLLLTFGK-KRTQEVTHYQYTGWPEHMGP
 .. ||. |  .| ..||||... |       .| .||||.| | ..|    ........ ..|.  ...|.| ||. . . |..||.|||..||.|  |
tvedFWrmvweekvkiivmlteeeen......gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp

KDAEEIRYLLKLVTDSER----PVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRKCAAPDPIYLAFAFYT
....... ||. |. |..    |. |.| .| ||...||.|... . ... ..  ..  ..... |..|  .      ..|.  .
dstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyea
PTPc_SM00194 939-1117 1.6e-32 108.3 In-house 81-257 (263) alignment 
Range on Protein: 939-1117
Range on HMM: 81-257/263.0
AIAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCTKSISKP-LLKTRQLLLTFGK-KRTQEVTHYQYTGWPEHMGP
 .. ||. |  .| ..||||... |       .| .||||.| | ..|    ........ ..|.  ...|.| ||. . . |..||.|||..||.|  |
tvedFWrmvweekvkiivmlteeeen......gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp

KDAEEIRYLLKLVTDSER----PVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRKCAAPDPIYLAFAFYT
....... ||. |. |..    |. |.| .| ||...||.|... . ... ..  ..  ..... |..|  .      ..|.  .
dstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyea
0045098 (Phosphotyrosine protein) phosphatases II 939-1116 4.8e-25 83.9 In-house 76-266 (278) alignment 
Range on Protein: 939-1116
Range on HMM: 76-266/278.0
AIAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLTF-----GKKRTQEVTHYQYTGWPEH
 .|.||. .. .. ..||||... | .      .. |..|.|   .. |.  |.|.|...    .   .| ||.|          . .|||..|..||.|
tvadfwrmlwelgitvivmltelvelg......rekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh

MGPKDA--EEIRYLLKLVTD-----------------SERPVFVVCNTGGGRSAAFVLIESLFQAIntsEtGEINYRSLIEQTRSKRKC-AAPDPIYLAF
  | .     .  ||. . .                 |. ||.| |. | ||....|..  . . .   | | ... . ... ||.| . | . .  . |
gvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...e.ggvdlleavkelrsqRpglavqnleqyrf

AFY
 ..
lye
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 939-1104 6.1e-22 73.0 In-house 102-261 (288) alignment 
Range on Protein: 939-1104
Range on HMM: 102-261/288.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTElDEKLILADLTITCTKSISKPLLKTRQLLLTfGKKRTQEVTHYQYTGWPEHMGPKD
..  ||| |  || |||||| .. |       .| .|..|.|.. |..    ..|.| ..|  .    .|.|||   ||   |.|.|||..||.|  |..
tvndfWelvyenktstivmltelve......ggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPes

AEEIRYLLKLV---TDSE-RPVFVVCNTGGGRSAAFVLIESLFQAINTseTGEINYRSLIEQTRSKRKCA
....  ||. |    ...  |. |.|  | ||.  |. .. | .|...  .  |.  . ... | .|.  
kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRall
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 939-1104 7.9e-22 72.7 In-house 96-258 (281) alignment 
Range on Protein: 939-1104
Range on HMM: 96-258/281.0
AIAAFWESVKLNKPSTIVMLCdfaeidHFIGANKVNCDRYFPtELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRTQEVTHYQYTGWPEHMGPKD
...|||. |  .| |.|||.       . | |.|. | ||.| . ...|...|.|.. |.. .|.   .|.. |.  .  |.||.. .|| ||.|  |..
slvafWqmvweqkvsaivmvt......reieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPat

AEEIRYLLKLV---TD--SERPVFVVCNTGGGRSAAFVLIESLFQAINtSETGEINYRSLIEQTRSKRKCA
..|.    | |   |.  .. |. . | .| ||. ... .. |..|.. .|. |.. . .... | .|.  
tkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave.aeleeldvkavvaelrkernlm
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 939-1102 7.3e-18 59.7 In-house 64-222 (250) alignment 
Range on Protein: 939-1102
Range on HMM: 64-222/250.0
AIAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVnCDRYFPTELDEKliLADLTITCTKSISKPLLKTRQLLLTFGKKRTQ-EVTHYQYTGWPEHMGPK
.|  ||  |  .| .||||| .. | .      |. . .|.|.|  ||    |.|..  ..  .  ...|.| |.  ||  .  | ..... ||.   |.
tiedfWrmvleeksgtivmLtnLkese......kt.yhqywPvekaek..yGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPe

DAEEIRYLLKLVTDS-----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
 |. .  ||| |  |     ..|| | | .| ||| ||. |..... ......  .. . .|.. | .| 
vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekv..vdvfkvikvlrkdrp
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 939-1102 2.3e-17 58.2 In-house 111-270 (298) alignment 
Range on Protein: 939-1102
Range on HMM: 111-270/298.0
AIAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDEKLilADLTITCTKSISKPLLKTRQLLLTFG-KKRTQEVTHYQYTGWPEHMGPK
... ||  |  .. .||||| .  | |      |... .|.|.|  |.    ..|..  .. ..  | .|.| ..   .....|| . ..| ||..  |.
tvedFWrmvteedigtiVmltnleeld......ktkyhkywPdegkety..geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpe

DAEEIRYLLKLVTDS-----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
 |. .  ||. |  |     ..|| | |  | ||| .|. |.|... ......  .  .  ..  | || 
natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqv..vDvfqvvkvlRkkrp
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 939-1116 3.2e-17 57.4 In-house 76-258 (270) alignment 
Range on Protein: 939-1116
Range on HMM: 76-258/270.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCT--KSISKPLLKTRQLLLTfGKKRTQEVTHYQYTGWPEHMGP
.. .||  .  .| ..|||. .. |       .. .|.||.|.| .||. |.| .|. .  ..  .    ...| |.  |  .....|..|. ||.|  |
tlksfwrmiweekvtaivmttgleE......kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvp

KDAE------EIRYLLKLV------TDSERPVFVVCNTGGGRSAAFVLIESLFQAINtsETGEINYRSLIEQTRSKRKCAAPDPIYLAFAFY
....      .. ..|. |      .| . |. | |  | ||.  .....  .....  ||....  ..||. | .|      |   .|.. 
reedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe..etkkvdvlaiieelRkdRmalvqhpeqyeflyk
subfamily_Ptp69D_pd Subfamily Ptp69D 939-1102 8.2e-17 56.3 In-house 103-266 (307) alignment 
Range on Protein: 939-1102
Range on HMM: 103-266/307.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTEldEKLILADLTITCTKSISKPLLKTRQLLLTFGK------KRTQEVTHYQYTGWPE
 |  ||  .   .  .|||| .  |       |. .|..|.| |  ..    |. ... .. ...    |.| ..  |      . ...|. |.||||..
tigDfWRmiaeqevtlivmlsnlte......knrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkD

HMGPKDAEEIRYLLKLV----TDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
 . |. |. .  |.. |      .. |. | |..| |||. || ..||.| ... ..  ..    . . ||.|.
skvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedk..vdifetvkdLrsqRn
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 939-1082 1.1e-16 55.7 In-house 85-230 (274) alignment 
Range on Protein: 939-1082
Range on HMM: 85-230/274.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEK--LILADLTITCTKSISKPLLKTRQLLLTFGKKrTQEVTHYQYTGWPEHMGP
..| ||. .  .. . |||| .. |      ||.  | .|||.. | .      |. |. .| ...   . |.|.|   .. ...|.|| || ||.|  |
tvadfWrmiyqeevqvivmltklke......aneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksP

KDAEEIRYLLKLVTDSE-------RPVFVVCNTGGGRSAAFVLIESLFQAINT
.||...  |.. | .|.        || | |  | ||  .|. |.   . .. 
ddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre
0041856 (Phosphotyrosine protein) phosphatases II 939-1111 2.4e-16 55.3 In-house 46-162 (182) alignment 
Range on Protein: 939-1111
Range on HMM: 46-162/182.0
AIAAFWESVKLNKPSTIVMLCdfaeidhfigankvnCDRYFPTELdekliladltitctksiskpllktrqllltfgkkrTQEVTHYQYTGWPEHMGPKd
 .|.|.. .| .. .|||.|.               ...|.|..|                                   ......|.|..|| |  |  
tvadflrmlkelgittivnlt...............eelywpell...................................erlgiqylylpwpDhgvpd.

AEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAintsetgEINYRSLIEQTRSKRK--CAAPDPIYL
 .|.  ... | ....||.| |. | ||....|..  . .        ...... ... ||.|   .  |. ...
ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.......gvsleeavklvrsrRpgmvitpnqyff
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 939-1101 6.5e-15 49.8 In-house 99-256 (315) alignment 
Range on Protein: 939-1101
Range on HMM: 99-256/315.0
AIAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLlLTFGKKRTQEVTHYQYTGWPEHMGPKD
..  ||. |  .|..||||. .  | |      |..| .|.| .  .   .  . ..  .  .     .|.|  |   . .. || .|.|.||..  .|.
svddfwrmvlqekvttivmvtkkqegd......kikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkq

AEEIRYLLKLVTDS----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEInyRSLIEQTRSKR
.  .  |.| |  .    | ...| | .| ||.  .. |..  . |. ... ..    .... |.||
tssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdv..fnfvknlrakr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 939-1100 3e-14 47.8 In-house 104-262 (297) alignment 
Range on Protein: 939-1100
Range on HMM: 104-262/297.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKvNCDRYFPTELDEKliLADLTITCTKSISKPLLKTRQLLLTFGK-KRTQEVTHYQYTGWPEHMGPK
..| ||  |  ...|||||| |  |       .| .| ||.. .   .  . |.... .   ..     |.| .| || | .. |  ||.. ||..  ..
tvadfWamvldeqvstivmlnddne......rdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver

dAEEIRYLLKLVTD--------SERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSK
  .....||||...        .| |..| | .| || . .. |.|    ..  .  |..   |... | .
.kdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrek..evdifglvkklrqe
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 939-1102 8.6e-14 45.9 In-house 108-269 (305) alignment 
Range on Protein: 939-1102
Range on HMM: 108-269/305.0
AIAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCTKSISKPLLK-----TRQLLLTFGKKRTQEVTHYQYTGWPEH
.|  ||  |  ||   |||||   |.       |..| .|.|.   ||| |    .    | |||. .        | ||.  ...  | | |.| ||. 
tidefwwmviqnkveqivmlcktvel......gklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdr

MGPKDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEiNYRSLIEQTRSKRK
  |        ||  .  |. |. | | .| ||. . | || ... |            |.   | .| 
gvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcp.pmpelvkalrdqra
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 939-1120 2.2e-13 45.3 In-house 80-253 (284) alignment 
Range on Protein: 939-1120
Range on HMM: 80-253/284.0
AIAAFWESVKLNKPSTIVMLCdfaeidhfiganKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRTQEVTHYQYTGWPEHMGPKD
..| ||  .   . ||||.|             | .| .|.| . ..|    .. ..  .  ..  ..  .|     .|  .... . . |||..  |. 
tladfWrmiweyncstivllt............kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdy

AEEIRYLLKLV------TDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTLT
. ..  |.| |       . .... | | .| ||. ... .. |.. ..  .   ..   .... | .|.    | .   | . . | 
psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 939-1119 3.2e-13 44.7 In-house 116-288 (319) alignment 
Range on Protein: 939-1119
Range on HMM: 116-288/319.0
AIAAFWESVKLNKPSTIVMLCdfaeidhfiganKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRTQEVTHYQYTGWPEHMGPKD
..| ||  .   . ||||.|             |  | .|.| . ..|    .. ..  .  ..  ..  .|     .|  ...| . . |||..  |. 
tladfWrmiweyncstivllt............kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy

AEEIRYLLKLV------TDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTL
. ..  |.| |       . .... | | .| ||. ... .. |.. ..  .   ..   .... | .|.    | .   | . . |
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 939-1103 1.4e-11 38.9 In-house 94-252 (288) alignment 
Range on Protein: 939-1103
Range on HMM: 94-252/288.0
AIAAFWESVKLNKPSTIVMLCDFAEIdhfiGanKVNCDRYFPTELDEKLILADLtITCTKSISKPLLKTRQLLLTFGKKRTQE---VTHYQYTGWPEHMG
.|  .|. .  .    |||||.. |     |  | . . |||..| ||  .  |  | .|   . . |. .. |   .| ..|   | .  .  |...  
tieelWkmllesdveyivmlcellek....G..keksaeyfPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgv

PKDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTseTGEINYRSLIEQTRSKRKC
|..      ||. . . ..|. | ...| ||.....||    ...    .  .  |||... | .|. 
PenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrl..ddflgirsllaklreerfk
subfamily_PTPN14_pd Subfamily PTPN14 939-1102 1.7e-11 38.7 In-house 105-276 (300) alignment 
Range on Protein: 939-1102
Range on HMM: 105-276/300.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTE--LDEKLILADLTITCTKSISKPLLKTRQLLLTF-GKKRTQEVTHYQYTGWPEHMG
..  ||. |  .. . |||| .  |        |  . .||| .    ...      .|   | . . . |..| | .   |. ..| | ||| ||.|  
tvqdfWqmvWeqgvqlivmlteeee......dgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgv

PKDAEE-IRYLLK-----LVTDSER-------PVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRK
|.| .. . || .       |.||.       || | |  |.||.   .| . | ..... |  ||. .. ... | .| 
PeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehne..eidikkvlarLreqrm
subfamily_eak_pd Subfamily eak 939-1038 5e-11 36.6 In-house 105-197 (332) alignment 
Range on Protein: 939-1038
Range on HMM: 105-197/332.0
AIAAFWESVKLNKPSTIVMLCDFAEIDhfIgaNkvNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKrTQEVTHYQYTGWPEHMGPKD
 . |||. |  .|  .||.| .  | .  .  .  . |.||| .  |.|    | ... . . .  |.||.| |. | . | .| ||.. || |   || 
kvfafwqmvleqkspaivqlledvelk..l..e..ksdkyfpdktreelkfGildverkefvkrniletrllelskGne.thrvlhykvfGwtettlpky
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 939-1083 1e-09 32.5 In-house 100-249 (305) alignment 
Range on Protein: 939-1083
Range on HMM: 100-249/305.0
AIAAFWESVKLNKPSTIVMLCDFAEIdhfiGANKvnCDRYFPTELDEKLILAD----LTITCTKS-------ISKPLLKTRQLLLTFGKKRTQEVTHYQY
. | ||     .|  .| |||.. |     ||.|  |  ||... ...| . .    ... .  |        .|  ..  .|..    .... |||| .
tcadfwymclqdkveaifmlcnllek....gakk..cleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhw

TGWPEHMGPKDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTS
  ||.   |     |  ||.    |  |. | | .| ||. . |..| ... . . 
idwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllag
subfamily_ptpA1_pd Subfamily ptpA1 939-1071 1.9e-09 31.8 In-house 101-247 (418) alignment 
Range on Protein: 939-1071
Range on HMM: 101-247/418.0
AIAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEK-L--------ILADLTITCTKSISKPL--LKTRQLLLTFGkKRTQEVTHYQY
.|| ||  |  |.   ||||   .|        ...||||.| ..  . .        ..   ..   . |  |   . ||.. |||    |...|.|||
tiadfwrmvwenrcriivmlsrese......ncrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.getrditqyqy

TGWPEHMGPKDAEEIRYLLKLVTDS----------ERPVFVVCNTGGGRSAAFV
 |||.|  |  .. .| ||. .|.           . |. | |..| ||. .|.
egwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfc
subfamily_PTPRN_pd Subfamily PTPRN 939-1102 6.1e-09 30.0 In-house 112-272 (297) alignment 
Range on Protein: 939-1102
Range on HMM: 112-272/297.0
AIAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRTQEVTHYQYTGWPEHMGPKD
 .|.||. |  .    ||.|.  .| .        .|.||.| |  |   . .. .   .  ..  |     |  . ...|. || . .  |||.  |  
tvadfwqmvweqGvvvivnltrleeeg......vkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPas

AEEIRYLLKLVTDSER----PVFVVCNTGGGRSAAFVLIESLFQAINTSeTGEINYRSLIEQTRSKRK
|  .  . . |  | |    |. | |  | ||. ...||. . . ..     ||.  . .|  | .|.
aksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkG.vkeidiaatlehlrdqrp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 939-1102 1.1e-07 26.2 In-house 84-239 (267) alignment 
Range on Protein: 939-1102
Range on HMM: 84-239/267.0
AIAAFWESVKLNKPSTIVMLCDfaeidHFIGankvNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRTQEVTHYQYTGWPEHMGPKD
.|. |.. .. .| ..||.|        |..    |  ...| .. .     |||.  .    .   .   | | | .. ...|| | |  |      | 
titdfltvihdqkvpvivlltk.....vftd....nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkp

AeeIRYLLKL-----VTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEInYrSLIEQTRSKRK
   .. |. .     . . .||. | |. | ||| .|. |.| .. . | .. .| .  .. . ||.| 
y..lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdi.f.dflrkirsqri
Y_phosphatase Protein-tyrosine phosphatase 940-1103 8.6e-29 96.0 Pfam-A 55-218 (235) alignment 
Range on Protein: 940-1103
Range on HMM: 55-218/235.0
IAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCT-KSI-SKPLLKTRQLLLTFGKKRT--QEVTHYQYTGWPEHMG
|. ||. |  .| ..||||..  |       ....|..|.|.| .|.|   |...... |.   .    .|.| |.  |...  .||....||.||.|  
iedFWrmvwqekvkvivmltsleek......grekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgv

PKDAEEIRYLLKLVTDSE----RPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRKC
|......  |.. |  |.     || |.| .| ||.. ||... |.. ... |.  ..  ..... |..|  
pespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpg
Y_phosphatase Protein-tyrosine phosphatase 940-1103 8.6e-29 96.0 In-house 55-218 (235) alignment 
Range on Protein: 940-1103
Range on HMM: 55-218/235.0
IAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCT-KSI-SKPLLKTRQLLLTFGKKRT--QEVTHYQYTGWPEHMG
|. ||. |  .| ..||||..  |       ....|..|.|.| .|.|   |...... |.   .    .|.| |.  |...  .||....||.||.|  
iedFWrmvwqekvkvivmltsleek......grekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgv

PKDAEEIRYLLKLVTDSE----RPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRKC
|......  |.. |  |.     || |.| .| ||.. ||... |.. ... |.  ..  ..... |..|  
pespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpg
subfamily_PTPRD_pd Subfamily PTPRD 940-1102 2.4e-21 71.0 In-house 104-261 (564) alignment 
Range on Protein: 940-1102
Range on HMM: 104-261/564.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTElDeKLILADLTITCTKSISKPLLKTRQLLLT-FGKKRTQEVTHYQYTGWPEHMGPKD
|. ||  |  .. ||||||    |       .|| |..|.|.. . .    .||.| ...  .     |.. |.   .. ..||.....| ||.|  |. 
iedFWRmvweqnsstiVmltkleE......kgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

AEEIRYLLKLVTDS----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
|...  |.. |...    . |. | |. | ||. .|. |... . |....|  .. .. ... |..|.
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeekt..vDiyqyvkalrkqRn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 940-1102 1.6e-20 68.5 In-house 102-263 (305) alignment 
Range on Protein: 940-1102
Range on HMM: 102-263/305.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTF--GKKRTQEVTHYQYTGWPEHMGPK
.| ||. .   |.||||||..  |       .|  | .|.|..  ||  . ..... . . . . . .|.| ...  ..| .. |..|| | ||.|  |.
vadfWrliveekvstivmltklve......ggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpq

DAEEIRYLLKLVTD-----SERPVFVVCNTGGGRSAAFVLIESLFQAINTSetGEINYRSLIEQTRSKRK
 |  .  |.| |.       . |. |.|. | ||. .|. ..  .. ...   ....   .. | |||| 
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkE..evvdvfevlkqlRskrm
subfamily_PTPN23_pd Subfamily PTPN23 940-1115 1.2e-19 65.3 In-house 96-273 (288) alignment 
Range on Protein: 940-1115
Range on HMM: 96-273/288.0
IAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGK-KRTQEVTHYQYTGWPEHMGPKD
.. ||  |  .| |.|||| . .|       .| ..|||.|.. .|     ||..|. .  . .    |.| |.. . .....|.| |.| |||.  |. 
lnDFWlmvyeqkssviVmllskeel......gkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPas

AEEIRYLLKLVTD--------SERPVFVVCNTGGGRSAAFVLIESLFQAInTSETGEINYRSLIEQTRSKRKCAAPDPIYLAFAF
 |..  .|. | .        |. |. | | .| ||. .| |. .  ... . . | ..   .... | .|.    .   | |..
PetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsy
subfamily_PTPN12_pd Subfamily PTPN12 940-1103 1.4e-18 61.8 In-house 96-258 (290) alignment 
Range on Protein: 940-1103
Range on HMM: 96-258/290.0
IAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADLTITCTKS--ISKPlLKTRQLLLTFGkKRTQEVTHYQYTGWPEHMGPK
.  ||  .   . . .||.|   |.      .|  |.||.| | .|.|  .....|...   ...  .  |.| ...  | ...|. ..|| ||.|  |.
lddfWrmiweknveivvmaCrevel......gkkkCerYWpeegeeelefgefevtleeekavddd.flirtLkveaq.kesrkvyqfhYtaWPDhgvPs

DAEEIRYLLKLV----TDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSET-GEINYRSLIEQTRSKRKC
 |...  |..||    .... |. | |  | ||  . . |.   .....  .  |..  .|. . | .|..
saksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraa
subfamily_PTPN6_pd Subfamily PTPN6 940-1102 4.6e-18 60.3 In-house 111-277 (306) alignment 
Range on Protein: 940-1102
Range on HMM: 111-277/306.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLiLADLTITCTKSISKPLLKTRQLLLT--FGKKRTQEVTHYQYTGWPEHMGPK
.. ||. |  ..   |||.    |       .|  | ||.|.| ...    ....|.... |.   . |.|...    ||...|| .|... ||.|  ||
vsdFWrmvwqensrvivmttkevE......rgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpk

DAEEIRYLLKLVTD--------SERPVFVVCNTGGGRSAAFVLIESLFQAINTSET-GEINYRSLIEQTRSKRK
| . .  .|. |.         ...|. | |. | ||  .|..|. | . |... .  .|. ..|....|. |.
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrs
0043147 (Phosphotyrosine protein) phosphatases II 940-1116 5.1e-16 54.3 In-house 33-155 (172) alignment 
Range on Protein: 940-1116
Range on HMM: 33-155/172.0
IAAFWESVKLNKPSTIVMLCDFaeidhfigankvncdryfpteldekliladltitctksiskpllktrqllLTFGKKRTQEVTHYQYTGWPEHMGPkDA
.| ||. .| .. ..||.|...                                                  |. ... .... .|.|..|| |  | ..
ladfwrmlkelgithivnltel..................................................lydpellerlgiqylylpwpDhgvp.ll

EEIRYLLKLVTD-----SERPVFVVCNTGGGRSAAFVLIESLFqaintsetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFY
| .. .|... .     .. || | |  | ||....|..  .           ...   ... |.|| .| . | .. |  |
ellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsqyrflyy
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 940-1108 1.6e-15 52.0 In-house 104-269 (319) alignment 
Range on Protein: 940-1108
Range on HMM: 104-269/319.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLilADLTITCTKSISKPLLKTRQLLLTFG--KKRTQEVTHYQYTGWPEHMGPK
|  ||  |  .. |..|||.. .|        ||.. .|.|.|  |.     |..|  .   .  .  |.| |     .  | ||.|.||| ||.|  |.
iedfWrmvWeeessivvmltklve......klkvklkkywpeenfeey..GrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPe

DAEEIRYLLKLVTDS-----ERPVFVVCNTGGGRSAAFVLIESLFQAINtsETGEINYRSLIEQTRSKRKCAAPDP
.|  .  ||| .  |     ..|. | |  | ||  .|. ..  .. ..  | | ..  | . ..| .|..    |
katslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervk..eegvlDvfstvsrlRtqRnimvqrp
subfamily_PTPN1_pd Subfamily PTPN1 940-1113 6.5e-15 49.6 In-house 84-262 (290) alignment 
Range on Protein: 940-1113
Range on HMM: 84-262/290.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELD-EKLILA--DLTITCTKSISKPLLKTRQLLLTF-GKKRTQEVTHYQYTGWPEHMG
.. ||. |  .|  ..|||  . |       ... | .|.|.. . ..|.|    |...  .  .|   . |.| |.    ..|.|..|. || ||.   
vdhfWqmvWeqkskavvmlnkvve......keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgv

PKDAEEIRYLLKLVTD------SERPVFVVCNTGGGRSAAFVLIESLFQAINTSET-GEINYRSLIEQTRSKRKCAAPDPIYLAF
|.       .|  | .         |. . | .| ||| .|.|.....  |. ..    .. .  . . |. |      .  | |
pespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 940-1106 3.6e-14 47.5 In-house 95-261 (307) alignment 
Range on Protein: 940-1106
Range on HMM: 95-261/307.0
IAAFWESVKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFPTELDEKLILADL--TITCTKSIS------KPLLKTRQLLLTFGKKrTQEVTHYQYTGWP
.  ||  .  .|  ...|||.  |.       |..|..|.| |  .||. ..   ||. ..  .      . |..  .| . ...| .. ..|.|.. ||
qysfwamaiqekvesvimlckviel......akikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqk.srtiqhlqwenwp

EHMGPKDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETgEINYRSLIEQTRSKRKCAAP
..  |.       ||. |   . || | | .| ||| . | |  . . . . .    . . |.|. ||.|. |  
drgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin.ckdmkklveelrsqrhyaiq
0049260 (Phosphotyrosine protein) phosphatases II 940-1115 3.8e-14 48.1 In-house 22-143 (152) alignment 
Range on Protein: 940-1115
Range on HMM: 22-143/152.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFpteldekliladltitctksiskpllktrqllltfgkkrtqevtHYQYTGWPEHMGPKDA
.| ||. .| .. .|||||... |       .|. |..|.                                            .|... || |  |...
ladfwrmlkelgittivmltelle......lgklkceqyi............................................qylhlpwpDhgvpdls

EEIRYLLKLV----TDSERPVFVVCNTGGGRSAAFVLIESLFqaintsetGEINYRSLIEQTRSKRKCAAPDPIYLAFAF
. .. ||...     |.. ||.| |  | ||....|..  .           ...   ... |.||..| | | .| | .
qlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 940-1100 6.9e-14 45.8 In-house 99-254 (515) alignment 
Range on Protein: 940-1100
Range on HMM: 99-254/515.0
IAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKrTQEVTHYQYTGWPEHMGPKDA
.  ||  |  ....||.|. .  | |      |..| .|.|    . . .  . .      .      |.| .. |.. .. || ...|.||..  ||..
vddfWrlvlqenvttiamvtklkegd......kikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkht

EEIRYLLKLVTDS----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEInyRSLIEQTRSK
  .  |.| |  .    . |. . | .| ||   .. |.|    ..|... ..    .... | |
ssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdv..fnfvtnirqk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 940-1102 1e-13 46.1 In-house 102-260 (318) alignment 
Range on Protein: 940-1102
Range on HMM: 102-260/318.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTEldEKLILADLTITCTKSISKPLLKTRQLLLTF-GKKRTQEVTHYQYTGWPEHMGPKD
|  ||  |   . ..|||| .  |      . |. ..||.| .  .   . .|... .....   .  |.. .|  ... ...|  |.|| ||..  |..
ieDfWrmvWeqnsavivmltqeee......rgkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpes

AEEIRYLLKLVTDSE-----RPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
. ..  |.. |.  .     .|. | | .| ||   |. ...| . |.  ..  ..    ..| |..|.
gaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaeal..vDvfqtvkqlreqrn
subfamily_PTPRK_pd Subfamily PTPRK 940-1087 2.1e-13 44.8 In-house 99-244 (314) alignment 
Range on Protein: 940-1087
Range on HMM: 99-244/314.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEkliLADLTITCTKSISKPLLKTRQLLLTF---GKKRTQEVTHYQYTGWPEHMGP
.. ||  |  .. ..|||| .. |        .|.| .|.| . .      |. ... ..  .  | .| . ..    |.. ..|| ..|..|||.|  |
vkdfWrlvydencasivmltelve......vgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvP

KDAEEIRYLLKLVT----DSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGE
. |. .  |.. |     ... .. | | .|.||. .|. |... . |.. .. .
vsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvd
0046846 (Phosphotyrosine protein) phosphatases II 940-1117 5.3e-13 44.6 In-house 36-168 (176) alignment 
Range on Protein: 940-1117
Range on HMM: 36-168/176.0
IAAFWESVKLNKPSTIVMLCDFAEIDHfigankVNCDRYFPTELDEKLiladltitctksiskpllktrqllltfgkkrtqevtHYQYTGWPEHMGPKDa
.|.|.| .| .. ...|.|..  |...      ..|..|.| . ....                                    .|....||.|  | . 
ladflemlkelgitavvnlteevelgr......lkcpnywpeleklgi....................................qylhlpwpDhgvpdl.

EEIRYLLKLVTDSE---RPVFVVCNTGGGRSAAFVLIESLFQaintseTGEINYRSLIEQTRSKRK-CAAPDPIYLAFAFYT
| .  ||... .     .|| | |  | ||....|..  |           ...   ... |..|  .| . | .. |  . 
elllellefirealkeggpvlVHCsaGigRtgtlvaayllel......ekglsveealalvreqRplgavqtpeQyrflyef
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 940-1102 2.9e-12 41.1 In-house 104-263 (290) alignment 
Range on Protein: 940-1102
Range on HMM: 104-263/290.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTElDEKLiLADLTITCTKSISKPLLKTRQLLLTFGKK--RTQEVTHYQYTGWPEHMGPK
.. ||. .. .| . ||||..  |       .||.|  |.|.. | |  .   .|. ..  .     .|.| ..  ..  ..|.||.|| | |...   .
lvdFWkliwqekvtiivmltniie......egkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvt

DAEEIRYLLKLVTD-----SERPVFVVCNTGGGRSAAFVLIESLFQAINTseTGEINYRSLIEQTRSKRK
. . |  ... ...      .... | |  . |||| |. ..   .  .|  .| |.  ..... |... 
npqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckt..egvidvfqvlksqRiqkp
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 940-1087 3.3e-12 40.7 In-house 95-243 (312) alignment 
Range on Protein: 940-1087
Range on HMM: 95-243/312.0
IAAFWESVKLNKPSTIVMLCDFAEIDHFIGANKVnCDRYFPTELDEKLILADL-TITCTKSISKPLLKTRqLLLTFGKKRTQE--VTHYQYTGWPEHMGP
.. ||. .     ..|..|| | |      |. . .|     .|... . ..  |       ||  .  | .|    |   ||  . |||.. ||.|  |
cthfwqlalslgstsiillcgfvedgsekcakyi.sdivgfvdledhrvyteycteieiggkskdkithr.vlkvvvkatgqesklnhyqwaswpdhgmp

KDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGE
   .    ||  |    .||   | .| ||. ...||||.  |.      .
dscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqn
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 940-1101 9.5e-12 39.5 In-house 99-257 (287) alignment 
Range on Protein: 940-1101
Range on HMM: 99-257/287.0
IAAFWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDekLILADLTITCTKSISKPLLKTRQLLLTFGK--KRTQEVTHYQYTGWPEHM-GP
.  ||. .. .....|||||.  | |      .  | .|.|.|    ..| . .|. ..   .     |.| ..  .  . .|.|. ||.| |...   .
arnfWkliddrnvtaivmlcqekend......eevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvt

KDAEEIRYLLKLVTD----SERPVFVVCNTGGGRSAAFVLIESLFQAINTseTGEINYRSLIEQTRSKR
. .  .  . . .      .. .. | |  . |||| |. ..   .  .|   | |.  ..... | ..
epqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckt..eGviDvfqvlksqriqk
0051082 (Phosphotyrosine protein) phosphatases II 940-1101 1.2e-11 40.0 In-house 22-132 (151) alignment 
Range on Protein: 940-1101
Range on HMM: 22-132/151.0
IAAFWESVKLNKPSTIVMLCDFAEIDhfigankvNCDRYFPTELdekliladltitctksiskpllktrqllltfgkkrtQEVTHYQYTGWPEHMGPKDA
 |.|.| .| .. .|||.|..  |..        .| .|.| .                                      ||.|.....||..  |   
ladflellkelgiktivnlrseeerg........ycpeylpelg....................................ievlhipildwpdpglplsf

EEIRYLLKLVTDS-ERPVFVVCNTGGGRSAAFVLIESLFQAintsetgeINYRSLIEQTRSKR
.... .|.|. |  . ||.| |. | ||....|..  . .         ... . .|. |.||
davleflellldkkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 940-1114 5.4e-11 37.0 In-house 88-262 (285) alignment 
Range on Protein: 940-1114
Range on HMM: 88-262/285.0
IAAFWESVKLNKPSTIVMLCDFAEidhfIGANKvnCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLT--FGKKRTQE---VTHYQYTGWPEHM
.. ||  .  .| . ..||| . |     | .|  |  |.| .| | . .    || |.   . .  |    ||    .  . |   . | |   ||...
lsdfwhmiyqekiayvlmlctlfe....ggvek..calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdql

GPKDAEEIRYLL---KLVTDSERPVFVVCNTGGGRSAAFVLIEslFQAINTSETGEINYRSLIEQTRSKRKCAAPDPIYLAFA
 |.||  .  |    | |   |.|. | |..| ||.|.|| |.  . .|   |  .|.   .. . |. |  |    . . | 
apedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgid..yatirimenpniemldivremramrfqavqshmqflfl
subfamily_PTPRA_pd Subfamily PTPRA 940-1085 3e-10 34.5 In-house 114-260 (330) alignment 
Range on Protein: 940-1085
Range on HMM: 114-260/330.0
IAAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTEldEKLILADLTITCTKSISKPLLKTRQLLLT-----FGKKRTQEVTHYQYTGWPEHM
.  ||  .   | .||||| .. |       ..  | .|.|.|    .   .....  ..     .  |..|..       .|... |. . .|.||.  
vedfwrmiweqksativmltelke......rkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG

GPKDAEEIRYLLKLVTDS----ERPVFVVCNTGGGRSAAFVLIESLFQAINTSET
 | ..  .  ||| |         |. | | .| ||. .|. ...... ... . 
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 940-1043 7.9e-07 23.2 In-house 89-187 (297) alignment 
Range on Protein: 940-1043
Range on HMM: 89-187/297.0
IAAFWESVKLNKPSTIVMLCDFAEidhfIGANKvnCDRYFPTELDEKLILADLTITCTKSISKPLLK--TRQLLLTFGkKRTQEVTHYQYTGWPEHMGPK
.  ||. |  .   .|||.. . |     | .|  |  |.|   .|.|  .|. .    | |    .    .| | .  .... |.| |. .||.|  | 
vddfwtlvaeqdvrvivmvaklqe....dGrdk..capywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.sesrvvrhvqflswpdhGvps

DAEEIR
| |.. 
dledlv
subfamily_CG7180_pd Subfamily CG7180 940-1102 3.1e-06 21.0 In-house 98-270 (296) alignment 
Range on Protein: 940-1102
Range on HMM: 98-270/296.0
IAAFWESVKLNKPSTIVMLCDFAEIDH----FIGAN-KVNCDRYFpTELDEKLILADLTITCTKsISKPLLKTRQLlLTFGKKRTQEVTHYQYTGWPE-H
. .||. |  .. |..|.|..  .  .    ..  . | .    |  |. |.  .|.|.|   | . | .. . .   .  |  |  |...|.| |.  .
vdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeif.veiveekqyanlkirtfk.ltkkivalteq.ekqvkaetRivklfqlteWeled

MGPKDA-------EEIRYLLKLV--TDSERPVFVVCNTGGGRSAAFVLIESLFQAINtsETGEINYRSLIEQTRSKRK
  |  .       . .| . . |   . | || ||.. |..|| ... |.   . ..  ...|..    . . | .|.
kvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelve..keeevdvFeavktlrrsRp
subfamily_PTPRB_pd Subfamily PTPRB 941-1103 2.4e-20 67.8 In-house 108-266 (293) alignment 
Range on Protein: 941-1103
Range on HMM: 108-266/293.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDeKLILADLTITCTKSISKPLLKTRQLLLTFgKKRTQEVTHYQYTGWPEHMGPKDAE
  ||. |  .| |.|||| .  |        || |..|.|.. .   .  |...| ... ..    .|.|...  .|....|..|..| ||.|  |....
ddfWrmvwekkssiivmltqlve......kgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektk

EIRYLLKLVTDS------ERPVFVVCNTGGGRSAAFVLIESLFQAINTseTGEINYRSLIEQTRSKRKC
 .  ... | ..      .||. | |  | ||. .|. .. |.|||..  .  ..  ... . |..|..
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnl
subfamily_PTPN3_pd Subfamily PTPN3 941-1106 2.6e-20 67.5 In-house 98-259 (280) alignment 
Range on Protein: 941-1106
Range on HMM: 98-259/280.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTeLDEKLILADLTITCTKSISKPLLKTRQLLLTFGK-KRTQEVTHYQYTGWPEHMGPKDA
. ||. |. .| |.|||| .  |        .| | .|.|.  ...| .......|.|. ..    .|.|.|.  . |. ..... ||. ||.|  |.|.
tdfWqmvweqksslivmlttlve......rGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPdds

EEIRYLLKLVTD----SERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRKCAAP
...  ... | .    .|.|| | | .| ||.  ..|.|  .. |...|  ...   .. . | .|..  .
adflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaae..pvypldivrtmrdqramlvq
subfamily_PTPN13_pd Subfamily PTPN13 941-1103 3.1e-17 57.7 In-house 91-250 (273) alignment 
Range on Protein: 941-1103
Range on HMM: 91-250/273.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILAD-LTITCTKSISKPLLKTRQLLLTFG-KKRTQEVTHYQYTGWPEHMGPKD
. ||  |   | . |.|.    |       .|| |.||.| . ..|| . . |...  |   .  .. |.| ..    ....||.| ... ||.|  |. 
kdfwqmvweqkaeviamvtleke......kgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss

AEEIRYLL---KLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSEtgEINYRSLIEQTRSKRKC
|.|.  ..   . . ... |. | | .| ||| ... |. ... |.  .  |.. . .... | .|. 
aaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 941-1083 2.1e-16 54.4 In-house 108-246 (290) alignment 
Range on Protein: 941-1083
Range on HMM: 108-246/290.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRT--QEVTHYQYTGWPEHMGPKD
  .|  |  .| ..|||||.  |        |  |..|.| .  | | . ..|..|... .|     ...|    |.      . |..   ||..  .. 
idiwrmvlqekvaaivmlcelie......dGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals

AEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTS
.  .  .|. .     || | | .| ||. .|| ||   | .   
tlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldG
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 941-1085 3.2e-14 47.3 In-house 95-232 (281) alignment 
Range on Protein: 941-1085
Range on HMM: 95-232/281.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLTFgKKRTQEVTHYQYTGWPEHMGPKDAE
| ||  .  .. ..|||||.| |      .|. .|  ||| .    | .  |...   |  .  | | .| |.. .  |. .||. .  ||.   |. .|
adfwrmiwqenttaivmlcqfle......tnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsy.egetrlithwlwkewpdwqvpesse

EIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSET
 .  .|. .     |  . | .| ||| ... .|  .|.| .  |
vmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshft
subfamily_PTPRG_pd Subfamily PTPRG 941-1101 4.1e-14 46.7 In-house 105-266 (563) alignment 
Range on Protein: 941-1101
Range on HMM: 105-266/563.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLTF--GKK-----RTQEVTHYQYTGWPEH
  ||  .  .. ..|||. .. |       .. .||.|.|.  || . .  |..| ...  . |  .|.| .     ||       ..|..|.|| ||.|
ddFWrmiWeqnvaiivmitnlve......rgrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

MGPKD-AEEIRYLLKLVTDSER---PVFVVCNTGGGRSAAFVLIESLFQAINTSETGEInyRSLIEQTRSKR
  |.  . .. .  |  .  ..   |. | |..|.||.  .. ...| . |.. .. ..    .. . |..|
gvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnv..fgflkhiraqR
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 941-1081 1.1e-11 39.2 In-house 89-227 (283) alignment 
Range on Protein: 941-1081
Range on HMM: 89-227/283.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKliLADLTITCTKSISKPLLKTRQLLLTFG--KKRTQEVTHYQYTGWPEHmGPKD
  ||  |  .| ..||||  . |       ....| .|.| .  |.    ..|.|  |  ..  .  ..|||      | |  ..|||. .| |  |.. 
vdfWkmvfdekitaivmltklqe......dlrikCsqyWPkrGsed..yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWley.geqa

-AEEI---RYLLKLVTD-SERPVFVVCNTGGGRSAAFVLIESLFQAIN
  . .     .  | |.  . |. | | ||.||.|.|. . .  . . 
iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdal
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 941-1098 1.3e-10 35.9 In-house 59-218 (237) alignment 
Range on Protein: 941-1098
Range on HMM: 59-218/237.0
AAFWESVKLNKPSTIVMLCDFaeidhfIGANKVNCDRYFPTeLDEKLILADLTITCTKSISKPLLKTRQLLLTF--GKKRTQEVTHYQYTGWPEHMGPKD
  ||. |  .| | ||||  .      |  |.. | .|.|   |.      ||.. .|         | |||.    .|  . .  ||.| ||..  |. 
ddfwqmvwqekcsvivmltgl......iegnelkchkywps.tdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqq

AEE-IRYLLKLVTDSER-----PVFVVCNTGGGRSAAFVLIESLFQAINTSETGE-INYRSLIEQTR
.   .|.  ...  |.      |  . |..| ||.. |..|.....  .  .  .  ||   ||. |
taallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedr
subfamily_PTPN9_pd Subfamily PTPN9 941-1102 1.4e-10 35.7 In-house 99-270 (297) alignment 
Range on Protein: 941-1102
Range on HMM: 99-270/297.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADLTITCTKSISKPLLKTRQLLLT-FGKKRTQEVTHYQYTGWPEHMGPKDA
  ||  |  ..  .|||   . |        .. | .|.|.| ..    .||...  .  ..   |.|.| ..   ......|||.|...||..  |..|
sdfWrmvWeqevlvivmttrvve......rgrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssa

EEIRYLLKLVTDS-----------------ERPVFVVCNTGGGRSAAFVLIESLFQAINtsETGEINYRSLIEQTRSKRK
...  .|. | .                  . |. | | .| ||. .|. ..   . ..  |.| .. .  ... |..| 
aslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrle..evgtvdvvetvkllrtqra
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 941-1099 2.2e-09 31.8 In-house 65-220 (239) alignment 
Range on Protein: 941-1099
Range on HMM: 65-220/239.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELdEKLILADLTITCTKSISKPLLKTRqLLLTFGKKRTQEVTHYQYTGWPEHMGPKDAE
  ||  .  ..   ||||  . |        | .| .|.|     |     .|.  |. ..  ...|  ..   |.   . | .|..| ||..  |. | 
gdfwrmmwqerrcvivmltglie......ghkkkchqywpdst.skycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyat

EIRYLLKLVT-DS---ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEI-NYRSLIEQTRS
 .  | . .| ||    ||  . |..| ||. ||..|.....  .  .| .| ||   | . | 
avlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrp
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 941-1099 2.3e-09 31.8 In-house 66-221 (239) alignment 
Range on Protein: 941-1099
Range on HMM: 66-221/239.0
AAFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELdEKLILADLTITCTKSISKPLLKTRqLLLTFGKKRTQEVTHYQYTGWPEHMGPKDAE
  ||  .  ..   ||||  . |        | .| .|.|     |     .|.  |. ..  ...|  ..   |.   . | .|..| ||..  |. | 
gdfwrmmwqerrcvivmltglie......ghkkkchqywpdst.skycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqyhftvwpdkgvpqyat

EIRYLLKLVT-DS---ERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEI-NYRSLIEQTRS
 .  | . .| ||    ||  . |..| ||. ||..|.....  .  .| .| ||   | . | 
avlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrp
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 941-1102 6.1e-07 23.2 In-house 105-259 (439) alignment 
Range on Protein: 941-1102
Range on HMM: 105-259/439.0
AAFWESVKLNKPSTIVMLCDFAEIDHfigankvncdrYFPTelDEKLILADLTITCTKSISKPLLKTRQLLLTFGKKRT---QEVTHYQYTGWPEHMGPK
  ||  |  .| .|||||... |  .           |.|.  |.. .  |... . . |  |    | . .   . .|   . | ...|. ||..  | 
ddfwrlviekktvtivmltnlvesyk...........ywps..daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpa

DAEEIRYLLKLVT---DSE--RPVFVVCNTGGGRSAAFVLIESLFQAINTSETgeINYRSLIEQTRSKRK
.|  .  .|. .    |.|   || | | .| ||. . . ..  .. ... .   .. . ...  | .||
qashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenk..vdikgivkvlrkqrk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 942-1103 3.3e-21 70.3 In-house 105-262 (301) alignment 
Range on Protein: 942-1103
Range on HMM: 105-262/301.0
AFWESVKLNKPSTIVMLCDFAEidhfigANKVNCDRYFPTELDEKLILADL--TITCTKSISKPLLKTRQLLL--TFGKKRTQEVTHYQYTGWPEHMGPK
 ||  ..  .  .||||. . |       ..  |. |.|..  ||| .     .|. ...| .  .. |.| .  . ||  |. ||||||. |...  ||
dfwamlvqydvekivmlgqkve......kleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPk

DAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEINyrSLIEQTRSKRKC
   |.  |..|| .||.|. | |..| ||| ||.  | | .....  | |..    ... | .| .
shaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptielt..ealkhlrehrwn
subfamily_egg_pd Subfamily egg 942-1109 2e-06 21.7 In-house 98-257 (307) alignment 
Range on Protein: 942-1109
Range on HMM: 98-257/307.0
AFWESVKLNKPSTIVMLCDFAEIdhfigankVNCDRYFPTELDEKLIL--ADLTITCTKSIS--KPLLKTRQLLLTFGKKRTQEVTHYQYTgWPEhMGpk
 ||  |  ..   ||||    |          .|. |.|   .. |..    | |.. |  |   ||..  .| |  |..  . . |.|.  . . ..  
dfwrmvfqeevqyivmltsrkes........erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.vnn.ss..

DAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEINYRSLIEQTRSKRKCAAPDPI
|      .|... .  .|| | .  |  ..|..| ||  .  .    .     .  .   | .|. .   ..
dvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvl
0051429 (Phosphotyrosine protein) phosphatases II 943-1132 7.9e-18 60.5 In-house 38-235 (272) alignment 
Range on Protein: 943-1132
Range on HMM: 38-235/272.0
FWESvKLNKPSTIVMLCDFAEIdhfigaNKVNCDRYFP----------TELDEKLILADLTITCTKSISKPLLKTRQLLLTFG--KKRTQEVTHYQYTGW
||   | .. .|||.|..  |.      ....|||| |           . ..   . .|..|... . ..    | ||||.    . . ||.|..||.|
fwrl.kelgiktivdLrseeEr......grlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

PEHMGPKDAeeIRYLLKLVTDsERPVFVVCNTGGGRSAAFVLIESLFqaINTSETGEIN--------YRSLIEQTRSKRKCAAPDPIYLAFAFYTTLTLF
| |  |..|  .. ||.|. | ..|| | |. | .|.. .|..  |    . |..  ..        ..  .|. |..| .| ...  ..| .   | |.
pdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallell

YPANAHDDAY
..  . . .|
rsllsvraey
0049772 (Phosphotyrosine protein) phosphatases II 943-1108 5.5e-09 31.6 In-house 110-260 (314) alignment 
Range on Protein: 943-1108
Range on HMM: 110-260/314.0
FWESV--KLNKPSTIVM---------------------LCDFAEIDhfigankvncdrYFPTELDEK--LiladltitctksiskpllktrqLLLTFGKK
.|. |    ... .|||                     |... .               .||. | .                           |. ...
gwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............neptaadlellk......................eelydpel

RTQEVTHYQYTGWPEHMGPkDAEEIRYLLKLVTD--SERPVFVVCNTGGGRSAAFVLIESLFQAINtsetgeINYRSLIEQTRSKRKcAAPDP
 .... .| .. .| .  | . | .. .|... .   ..||.| |. | ||.. ||..  |  . .      ....  .|. |.||  . | |
ferlgikylripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRp.inpnp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 943-1101 8.1e-08 26.1 In-house 107-267 (302) alignment 
Range on Protein: 943-1101
Range on HMM: 107-267/302.0
FWESVKLNKPSTIVMLCDFAEIDhfiganKVNCDRYFPTELDEKLILADLTITcTKSISKPLLK----TRQLLLTF-------GKKRTQEVTHYQYTGWP
.|  ..  . . .| ||.| | .      .  |  |. ......| .   |.. |.|. . | .        | |         ||  . |   ....||
hwalieqynvaivvqlcsfvede......ekkcaeyysdkvggelkfgrytvk.tvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawp

EHMGPKDAEEIRYLLKLVTDSERPVFVVCNTGGGRSAAFVLIESLFQAINTSETGEINyrSLIEQTRSKR
.|  ||.|.    .||      . |.| | .| ||. ..| |    |   . .. ..   |..   |. |
dhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdll..sivlpvrqcr
0048076 (Phosphotyrosine protein) phosphatases II 978-1116 1.8e-12 42.6 In-house 2-137 (145) alignment 
Range on Protein: 978-1116
Range on HMM: 2-137/145.0
YFPTELDEKLILADLTITCTKSISKPLLKTR-QLLLTFGKKRTQEVTHYQYTGWPEHMGPKDAEEIRYLLKLVTDS---ERPVFVVCNTGGGRSAAFVLI
|.|.| ...| | .|. ..     | |  |.   | .  .  ......|.|..|| |  | ..| .. .|... .    ..||.| |. | ||....|..
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

ESLFQaintsetGEINYRSLIEQTRSKRKCAAPDPIYLAFAFY
  ...         ... . .|. ||.| .| | | .| | ..
ylmll.......lgvsleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 1012-1114 1.3e-11 40.0 In-house 48-137 (144) alignment 
Range on Protein: 1012-1114
Range on HMM: 48-137/144.0
LtfgkkrtqeVTHYQYTGWPEHMGPKDAEEIRYLLKLVTDS---ERPVFVVCNTGGGRSAAFVLIESLFqaintseTGEINYRSLIEQTRSKRKCAAPDP
          ...|....|| |  | ..| .. .|... .    ..||.| |. | ||....|..  ..       .  ... . ... ||.| .| | |
e.........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.......klglsleealalvrsrrpgavpnp

IYLAFA
 .| | 
gqlrfL
PTPc_DSPc_SM00012 1022-1102 3.6e-14 48.2 In-house 2-87 (105) alignment 
Range on Protein: 1022-1102
Range on HMM: 2-87/105.0
VTHYQYTGWPEHMGPKDAEEIRYLLKLVTDSER------PVFVVCNTGGGRSAAFVLIESLFQAINTSEtGEINYRSLIEQTRSKRK
|.||.|||||.|  |.....|  ||. | ....      || |.| .| ||.. ||... | | ..... .|..   .... |..| 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRp