Gene Y54F10BM.3 in Caenorhabditis elegans

Synonym: CELE_Y54F10BM.3, Y54F10BM.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP222_AA protein Get Run
CeleP222_AA_395-687 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 385-687 3.1e-48 160.1 In-house 6-294 (297) alignment 
Range on Protein: 385-687
Range on HMM: 6-294/297.0
KKLFTKMSYSPSMCSIIPGKERDPSKTVIANWFEWCQPEFEiPiELTAMSAGNPKLCRDPKVQAWDSTSYLV-------DDTHFIHASTVtaPGKEY-IG
..|.. .... |.. .. ..|.  |||.. ..||. .  .. .   .|..  | ...| . . ..|..   .        |. .|.|| |  .| ..   
dallesipiplsvldlllllekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltr

KAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVqKCGRYFPDETGateNYGFAEVQLLEKHEmlNGHLLTRKIELTSgtwkhsdDDP
| |..|.| ..       | |.||||||. . |..|| .. .|.|. || .|.|.|.|   .||   | ||. ..  ...  .|..|.|        ...
kfIatqgPlpe.......tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.......nge

PiRTITHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTRN--NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFW
. ||.||||...| ..   .  |  ......|... ..  .  |..||.| | ||...|..| .|......... ..      .| .| || |.  |. .
s.rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrf

VQNMAFELLIKKLK
......||| .||.
lydallellkrklt
0050432 (Phosphotyrosine protein) phosphatases II 396-687 3.3e-50 166.6 In-house 27-304 (308) alignment 
Range on Protein: 396-687
Range on HMM: 27-304/308.0
SMCSIIPGKERDPSKTVIANWFEWCQPEFEIPIELTAMSAGNPKLCRDPKVQAWDSTSYLVD-DTHFIHASTVTAPGKEYIGKAIICQAPFddkekghPD
|. ...   |.  ... .  .||  .  ....   .|.   | ...| . . ..|..   .| ....|.|| |. . . .  | |..|.|        |.
svldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPl.......pn

TRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETG-ATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGTwkhsddDPPIRTITHFQFLKWKEGE
| |.||||||. . ...|| ....|||..|| .|.|.|.|  ...||   | ||. ..  ...  .|..|||         |.. ||.|||... |... 
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlg......dgesrtvthfhytnWpdhg

GLEG-EMSMDAFNYVNHRTRNnlDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKLK
  .  |. .| ...|... ..   ||.||.| | ||...|. ............. ..      .|..| |. |.  |....  ...|.| .||.
vPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0036941 (Phosphotyrosine protein) phosphatases II 407-686 5.8e-52 172.2 In-house 9-281 (297) alignment 
Range on Protein: 407-686
Range on HMM: 9-281/297.0
DPSKTVIANWFEWCQPEFEIPIELTAMSAGNPKLCRDPKVQAWDSTSYLVDDTH--FIHASTVtaPGKEYIGKAIICQAPFddkekghPDTRESFWRMVW
  ... .  .||...| . ..   .|.. .| ...| . . ..|.|   .|| .  .|.|| |  .| ..  | |..|.|        |.| |.||||||
llflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv..dgydlkrkfIatqgPl.......pntvedFWrmvw

DTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGHLLTRKIELTSGtwkhsdDDPPIRTITHFQFLKWKEGEGLE-GEMSMDA
. . | .|| .. .|.| .|| .|.|.|.| . .||   |.||. ...|...  .|..|.|        .... ||.|||....| .    |  .  .| 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt......gngesrtvthfhytgwpdhgvpespaslldf

FNYVNHRTRN--NLDPIIVHSSLGTGRACAFVGAEYMFQMIN---TKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKL
...|... ..  .  |..||.| | ||...|..|..|.|...   . .. .   .   .|..| || |.  |. ..  . .||| |||
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 409-689 2.4e-50 167.0 In-house 16-283 (317) alignment 
Range on Protein: 409-689
Range on HMM: 16-283/317.0
SKTVIANWFEWCQPEFEIpIELTAMSAGNPKLCRDPKVQAWDSTSYLVDD------THFIHASTVtaPGKEYIGKAIICQAPFddkekghPDTRESFWRM
..|.. ..||...  .      .|.   |....| | .  .|..   . .      . .|.|| |  .| ..  | |..|.|        |.| |.||||
dftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPl.......pntvedFwrm

VWDTRATYVVMCCQIMENGVQKCGRYFPDetGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGtwkhsdDDPPIRTITHFQFLKWKEGEGL-EGEMSM
||. . |..|| .. .|.|..|| .|.|.  | | .||   |.||. .|  ...   |..|..        .|.. ||.|||... | ..      .   
vweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl......gdsesrtvthfhytgWpdhgvppspdlll

DAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKLKMH
| ...|..  ...  |..||.| | ||...|..|..|......... ..      .| .| || |.  |. ..  ...|.| .||.. 
dfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle
0047943 (Phosphotyrosine protein) phosphatases II 409-681 6.5e-48 158.9 In-house 10-271 (273) alignment 
Range on Protein: 409-681
Range on HMM: 10-271/273.0
SKTVIANWFEWCQPEFEIPIELTAMSAGNPKLCRDPKVQAWDSTSYLV--DDTHFIHASTVtaPGKEYIGKAIICQAPFddkekghPDTRESFWRMVWDT
..|...  ||. .. ...    .|.   | ...| . . ..|..   .  .....|.|| |  .| ..  | |..|.|        |.| |.||||||. 
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv..dgynlkrkfiatqgPl.......pntvedfwrmvweq

RATYVVMCCQIMENGVQKCGRYFPDETGA-TENYGFAEVQLLEKHEmlNGHLLTRKIELTSGTwkhsddDPPIRTITHFQFLKWKEGEGL-EGEMSMDAF
.....|| ....|.| .|| .|.|.| |  ...||   | ||. ..  ...  .|..|||.        ..  ||.|||....| .       |. .. .
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlg......tgesrtvthfhytgwpdhgvppslesllefi

NYVNHRTRN--NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFEL
..|..  ..  .  |..||.| | ||...|. ............. ..      .|..| |. |.  |. .. ....|.
elvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0051299 (Phosphotyrosine protein) phosphatases II 409-682 5e-47 156.1 In-house 21-286 (288) alignment 
Range on Protein: 409-682
Range on HMM: 21-286/288.0
SKTVIANWFEWCQPEFEIPIELTAMSAGNPKLCRDPKVQAWDSTSYLV------DDTHFIHASTVtaPGKEYIGKAIICQAPFddkekghPDTRESFWRM
..| ... ||.... .. .   .|.   | . .| . . ..|..   .      ... .|.|| .  .| ..  | |..|.|        |.| |.||||
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrkfIatqgPl.......pntvedFWrm

VWDTRATYVVMCCQIMENGVQKCGRYFPDetGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGTWKHsdDDPPIRTITHFQFLKWKEGEGLE-GEMSM
||. . ...|| ....|.|..|| .|.|.  | ...||   | ||. ..  ...  .|..|.|  .. .   |   ||.|||....| .    .  |. .
vweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlld..gdgesrtvthfhytnwpdhgvpdspelll

DAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELL
|  ..|..  ...  |..||.| | ||...|. ............. ..  .   .|..| |. |.  |. .|  ...|.|
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 411-684 1.3e-46 155.2 In-house 27-306 (307) alignment 
Range on Protein: 411-684
Range on HMM: 27-306/307.0
TVIANWFEWCQPEFE--IPIELTAMSAGNPKLCRDPKVQAWDSTSYLV-------DDTHFIHASTVTA------PGKEYIGKAIICQAPFDDkekghpdT
| .. .||. ...    .    .|..  | ...| . . ..|.|   .       .|...|.|| |.       .|     | |..|.| ..       |
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.......t

RESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGtwkhsDDDPPIRTITHFQFLKWKEGEGL
 |.||||.|. . |..||... .|.| .|| .|.||| | . .||   | ||....   ...  |..|.|       | . . ||.|||....| ..   
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdl.....dgtgesrtvthfhytgwpdhgvp

E-GEMSMDAFNYVNHRTRN--NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKC---GTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIK
.  |.  | ...|..  ..  .  |..||.| | ||...|..| .| ..... ..    ...     .| .| || ||  |. .......||| |
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
0043336 (Phosphotyrosine protein) phosphatases II 412-681 7.1e-46 152.3 In-house 21-276 (278) alignment 
Range on Protein: 412-681
Range on HMM: 21-276/278.0
VIANWFEWCQPEFEiPIELTAMSAGNPKLCRDPKVQAWDSTSYLVDD------THFIHASTVtaPGKEYIGKAIICQAPFDDkekghpdTRESFWRMVWD
.. . ||  .  .  .   .|..  | ...| . . ..|..   ...      . .|.||.|  .| ..  | |..|.| ..       | | ||||||.
llllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpe.......tvedFwrmvwe

TRATYVVMCCQIMENGVQKCGRYFPdetGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSgtwkhsDDDPPIRTITHFQFLKWKEGEGL-EGEMSMDAF
 . | .|| .. .|.|..|| .|.|   | ...||   | ||. ..  ...  .|..|.|         |.. ||.||...|.| ...     .. .|  
lgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtn......lgdgesrtvthyhylgwpdhgvpeslsllldfl

NYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFEL
..|... ...  |..||.| | ||...|............ .. ..     ..|..| ||.|.  |. .. ....|.
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045098 (Phosphotyrosine protein) phosphatases II 417-683 3.4e-40 133.6 In-house 13-273 (278) alignment 
Range on Protein: 417-683
Range on HMM: 13-273/278.0
FEWCQPEFEIPIELTAMSAGNPKLCRDPKVQAWDSTSYLvdDthFIHASTVTAPgKeyiGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQ
||.  . . .   ..|.  || ...| . ....|..     |  .|.|| .. . .    | |..|.|..       .| ..||||.|. . |..||...
fefllllgipseitpalylgnldknRykdilpydhsrVk..d..YINAsyidgy.p...kkfIatqgPlp.......stvadfwrmlwelgitvivmlte

IMENGVQKCGRYFPDetGATENYGFAEVQLLEKHEMlnGHLLTRKIELTSGTWKHSDDDppIRTITHFQFLKWKEGEGLEGE---MSMDAFNYVNHRTRN
 .|.|..|| .|.|.  | ...||  .| ||. ...  ..  .|....|  |....|.    |..||...| | ...  . .      ......... ..
lvelgrekcaqywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredle..srgvthlhylpwpdhgvpslpilksflellefirealkl

-------------NLDPIIVHSSLGTGRACAFVGAEYMFQMIntKKCGTARFFQVDFRTKRLG-ALQNGKQLFWVQNMAFELLI
             .  |..|| | | ||....|.| .| ...  ..  ..      .|..| | |.||  |. ..  .. ||| 
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 422-680 7.8e-10 32.8 In-house 34-277 (439) alignment 
Range on Protein: 422-680
Range on HMM: 34-277/439.0
PEFEIPIELTAMSAGNPKlCRDPKVQAWDSTSYLVDDTHFI-HASTVTApgkEYIgKAIICQAPFDDKEKGHPDTRESFWRMVWDTRATYVVMCCQIMEN
|...    |.| .  ..|  |  .| |.| |   ....  . |.  ..|   .|| |    .  .   .  . .| ..|||.|.. ... .|| ....| 
pdyaciaslaaqeydqtk.nrykdvgafdhtrvtlqeipgvphshyina...nyi.kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves

GVqkcgrYFPDETgaTENYGFAEVQLLEKHEMLngHLLTRKIELtsgtWKHSDDDPPIRTITHFQFLKWKEGEGLEGEMSMDAF-NYVNH-RTRNNLDPI
       |.| ..     ||   |.   . |.   .   | . .    ... |     ||. .|... | . .       .  |   .|    ...  |.
yk.....ywpsda..evcygdiavrvdrnielp..nyvirgfkv....fnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpv

IVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFE
.|| | | ||. . .  .  .. .....    .     .| .|   .|.  |  ...|  .|
vvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 423-688 5.4e-15 49.6 In-house 37-291 (302) alignment 
Range on Protein: 423-688
Range on HMM: 37-291/302.0
EFEIPIELTAMSAGNPKLCRDPKVQAWDSTSYLVD--DTHFIHASTVTAPGKEyiGKAIICQAPFDDKEkghpDTRESFWRMVWDTRATYVVMCcqIMEN
.. ...|   .   |.| .. ..|.. ||.   ..    ....||.|. |  .   . |. | |  | |    |  |.|||||.. . . ||.   ..|.
tmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt..rsiilaQlpkvdse....dsveeFWrmvfqekivsvvil..vgee

GVQK-CGRYFPDETGATENYGFAEVQLlEKHEMLNGHLLTRKIELTSGTWKHSdddpPIRTITHFQFlkWKEGEGLEGE-MSMDAFNYVNHRTRNNLDPI
 ..|    .|| ..|. ..||   |    | |  ...     ||.       |    .. .......  ||. ....     . .   | ... .  ...
elkktlselfpkksgdykeygkmfvNn.rkVekaeeektryviEvlPegcsns....vlanvyvltn..Wkqkkvpvkyaeliktaakvfakkikadent

IVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKLKM
.. |  |.||| ||. .   .. ....|   .       |..|  |... ||   .  ..  .. ||.. 
vivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
0046845 (Phosphotyrosine protein) phosphatases II 431-688 1.4e-45 151.2 In-house 22-280 (284) alignment 
Range on Protein: 431-688
Range on HMM: 22-280/284.0
TAMSAGNPKLCRDPKVQAWDSTSYLV-------DDTHFIHASTVTAPGK---EYIGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMEN
.|.   | ...| . . ..|..   .       .|...|.|| |. ..     .  | |..|.|        |.| |.||||||. .....|| ....||
vallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl.......pntvedFwrmvweqnvrvIVmltelven

GVQKCGRYFPDEtGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGtwkhsDDDPPIRTITHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTR--NNLDP
|..|| .|.|.| | . .||   | ||....  ...  .|..|||       . . . ||.|||....| .    .  |  .. ...|..  .  ..  |
grekcaqYwple.gevltygdftvtllseev..kddytvrtleltnl.....gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggp

IIVHSSLGTGRACAFVGAEYMFQMINTKK---CGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKLKM
|.||.| | ||...|. ............   . ..      .|..| |. |.  |. .| ....|.| .||..
ivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
subfamily_egg_pd Subfamily egg 431-638 5.7e-12 39.9 In-house 34-224 (307) alignment 
Range on Protein: 431-638
Range on HMM: 34-224/307.0
TAMSAGNPKLCRDPKVQAWDSTSYLVD------DTHFIHASTVTapGKEYIGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENgvQK
||.|. | . .|...|.  ||.   ..         ||||  |   ||  . . |..|||.        .| . |||||.  .  |.||     |.  ..
taasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplk.......ntvddfwrmvfqeevqyivmltsrkes..er

CGRYFPDETGATENY--GFAEVQLLEKHEMLNGHLLTRKIELTSGTwkhsdddppiR---TITHFQFlKWKEgeglEGEMSMdAFNyVNHRTRNNLDPII
|  |.|     .  .  |  ... |. ..  .  .   |. |  |           .    . |.|   ...     ... .  .. |  . ||   |..
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..........deerflehwqg.dvnn....ssdvys.plr.vlrklrnlskpvv

VHSSLGTGRACAFVGAEYM
|.. ||  .|...| .|  
vqdilGvskaatlvaieia
0040439 (Phosphotyrosine protein) phosphatases II 432-683 8.8e-41 135.5 In-house 6-247 (249) alignment 
Range on Protein: 432-683
Range on HMM: 6-247/249.0
AMSAGNPKLCRDPKVQAWDSTSYLVDD------THFIHASTVtaPGKEYIGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKC
|.   |....| | . ..|..   . .      . .|.|| .  .|  .  . |..|.| ..       | |.||||.|. . |..||... .|.| .||
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpe.......tvedfwrmlwelgitvivmLtslvelgrekc

GRYFPDetGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGtwkhsdDDPPIRTITHFQFLKWKEGEGL-EGEMSMDAFNYVNHRTRN--NLDPIIVHS
 .|.|.  | . .||   |.||. ..  .... .|..|||         |.. ||..|.|...| .       |  .| ...|..  ..  .  |..||.
aqywpl..ggsleygdftvtllsvev..kddytvrtleltnl......ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHC

SLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLI
| | ||...|..| .|......... ..     ..|..| || ||  |. .......||| 
saGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0037934 (Phosphotyrosine protein) phosphatases II 432-681 3e-34 114.1 In-house 5-241 (243) alignment 
Range on Protein: 432-681
Range on HMM: 5-241/243.0
AMSAGNPKLCRDPKVQAWDSTSYLVDDTHFIHASTVTAPGkeyigKAIICQAPFDDkekGHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPd
|..  | . .| . . ..| .   .... .|.|. .. ..     . |..|.| ..    . |. .|||||.|. . |..||... .|.|..|| .|.| 
allpenlsknrysdilpydhsrvklegsdyinanliyvtp.....rliatqgPlpe...tveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

etGATeNYGFAEVQLLEKHEMlnGHLLTRKIELTsgtwkHSDDDPPIRTITHFQFLKWKEGEGLE-GEMSMDAFNYVNHR--------TRNNLDPIIVHS
  | . .||  .|.||. ...  ..   |...|.     . | |.. |...|...| | ..   .  |  .| ...|.          ....  |..|| 
..gev.tygdftvtllseehl..ddytvrtllle.....nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SLGTGRACAFVGAEYMFQMIntkkCGTARFFQVDFRTKRLG-ALQNGKQLFWVQNMAFEL
| | ||. ... | .| ...    . ..     ..|..| | | |.  |. ... .. ||
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 432-683 2.6e-23 77.4 In-house 31-271 (285) alignment 
Range on Protein: 432-683
Range on HMM: 31-271/285.0
AMSAgNPKLCRDPKVQAWDSTSYLV--DDTHFIHASTVTAPGKEYiGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYF
|  | || | |   |.. . |  ..   |  .|||| .  |||.     |  | |.       |.|   ||.|... . .||.| | ..| ||.||  |.
ayea.npdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdq.styittqgpl.......petlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PDETGATENYGFAEVQLLE-KHEMLNGHLLTrkiELTSGTWKHSDDDPpiRTITHFQFLKWKEGEGLEGEMSMD-AFNYVNhRTRNNLDPIIVHSSLGTG
|.. |   ..|  |. | | | | . | .|     ||    . .  .|    . | |   | .    |    |   ...|. .   .  || || | | |
peklgevvkfgkyeitlteckeeaiagtiln...altvintedassep..lymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhcsagvg

RACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLI
|...||| .|    |  .          ..|. |. |.|.  |....  . .| .|
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfi
0042113 (Phosphotyrosine protein) phosphatases II 433-681 9.6e-41 135.2 In-house 5-242 (245) alignment 
Range on Protein: 433-681
Range on HMM: 5-242/245.0
MSAGNPKLCRDPKVQAWDSTSYLVD------DTHFIHASTVtaPGKEYIGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCG
.   |....| . . ..|.|   .       |. .|.|| |  .| .. .| |..|.| ..       | | ||||.|. . |..||... .|.| .|| 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpe.......tvedfwrmlwelgittivmLteeeelgrvkca

RYFPDetGATENYGFAEVQLLEKHEmlNGHLLTRKIELTSGtwkhsdDDPPIRTITHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTR-NNLDPIIVHSSL
.|.|.  | . .||   |.||. .   .... .|..|.|         |.. |...|...| | ..   .  |.  |....|..  . ..  |..||.| 
qywpl..gesltygdftvtllseeh..lddytvrtlevtnl......gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsa

GTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFEL
| ||...|..| .|...... .. ..     ..| .| || |.  |. ... ...||
GvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 437-677 2e-39 130.8 Pfam-A 1-232 (235) alignment 
Range on Protein: 437-677
Range on HMM: 1-232/235.0
NPKLCRDPKVQAWDSTSYLV----DDTHFIHASTVTAPGKeyIGKAIICQAPfddkekgHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDE
| | .| ... . |.|   .    ... .|.|..|.   .    | |..|.|        ..| |.||||||. . ...|| .. .|.| .|| .|.|.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgP.......lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

TGATENYGFAEVQLLEKHEMLNGHLLTRKIELTSGTWKHsdddpPIRTITHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACA
.. ...||  .|.| || .  . .  .||.||.. ....       |....... .|.. .  |  .  .|  . |.......  |..||.| |.||.. 
eeesltygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNM
|| .............     .   .|..| |. |. .|. .. ..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 437-677 2e-39 130.8 In-house 1-232 (235) alignment 
Range on Protein: 437-677
Range on HMM: 1-232/235.0
NPKLCRDPKVQAWDSTSYLV----DDTHFIHASTVTAPGKeyIGKAIICQAPfddkekgHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDE
| | .| ... . |.|   .    ... .|.|..|.   .    | |..|.|        ..| |.||||||. . ...|| .. .|.| .|| .|.|.|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke..kkkfIatQgP.......lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

TGATENYGFAEVQLLEKHEMLNGHLLTRKIELTSGTWKHsdddpPIRTITHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACA
.. ...||  .|.| || .  . .  .||.||.. ....       |....... .|.. .  |  .  .|  . |.......  |..||.| |.||.. 
eeesltygdikvelkekekedekeytlrklelkkkkees.....ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

FVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNM
|| .............     .   .|..| |. |. .|. .. ..
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka
0041856 (Phosphotyrosine protein) phosphatases II 439-685 1.4e-18 62.6 In-house 3-174 (182) alignment 
Range on Protein: 439-685
Range on HMM: 3-174/182.0
KLCRDPKVQAWDSTSylvdDTHFIHASTVTapGKEYIGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCqimengvqkCGRYFPdetgaten
.. | ...  .| .     | ..|.|. .   |  .  . |..|.| ..       | ..|.||... . |..|...         . .|.|        
dknrysdilpydhsr....dldyInanlyl..gslpatrfiatqgplls.......tvadflrmlkelgittivnlt.........eelywp........

ygfaevqllekhemlnghlltrkieltsgtwkhsddDPPIRTITHFQFLKWKEGEGLEgemsMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYM
                                    .   |.......| |  ..  .    .| ..   .. ...  |..|| | | ||....|.| .|
....................................ellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylm

FQMintkkCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKK
 ..       ...     .| .| |. ..  |.|..| ...|||  |
kkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 440-706 9.2e-11 36.0 In-house 46-297 (312) alignment 
Range on Protein: 440-706
Range on HMM: 46-297/312.0
LCRDPKVQAWDSTSYLV--DDTHFIHASTVTAPGKEyiGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATE
| | |..| ||   . .  |.  .|||  |    |    . ...|.|...       |   ||...    .| ... | ..|.| .|| .|  |  |  .
lnrypniqcwdrgrftlagdenfyihanfvkictkp..erfvctqgplen.......tcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

NyGFAEVQLLEKHEMLNGHLLTRKIelTSGTWKHSD-DDPPIRTITHFQFLKWKEgEGLEGemSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAE
      |      |.  |     ||  |    |           . |.|.  | .  |.    | |.   .    ...  |.| | | | ||. ...  |
l.edhrvyteycteieiggkskdki..thrvlkvvvkatgqesklnhyqwaswpd.hgmpd..scdtalrllsavkkdkkpviahcsagvgrtgtlalie

YMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKlkmhHLKFEMEEQWNFLKN-YS
 |   .   .    .   | .|  |  ...   |  ..    .|.|  |     |    |..|  .|. |.
smiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk....glykrneqewtkfketya
subfamily_PTPN3_pd Subfamily PTPN3 442-672 9e-26 85.4 In-house 46-265 (280) alignment 
Range on Protein: 442-672
Range on HMM: 46-265/280.0
RDPKVQAWDSTSYLVDDTH--FIHASTVT--APGKEYIGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDeTGATE
|   . ..|.|   .....  .| |..|    |... . . |..| |..       .| . ||.|||. ... .||  ...|.| .|| .|.|. |. . 
ryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPla.......ktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedel

NYGFAEVQLLEKheMLNGHLLTRKIELTSGTWKHSdddppiRTITHFQFLKWKEGEGLEGEM-SMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAE
.||  .|.. ..    .   ..|.. |.  . |..      |.|...|.| | . .  . .   ..  . |..  . . .|..|| | | ||.  ..  |
eygefsvkceke..detksyvlrelvlkdketkee......rkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

YMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLF
  ...|....           | .|   .|. .|  
talalieaaepvypldivrtmrdqramlvqtasqyk
0049772 (Phosphotyrosine protein) phosphatases II 444-686 2.4e-11 39.4 In-house 53-278 (314) alignment 
Range on Protein: 444-686
Range on HMM: 53-278/314.0
PKVQAWDsT-----SYLVDDTHFIHASTVTAPgkeyiGKAIICQAPfddKEkghpDTRESF----------WRMV--WDTRATYVVM-------------
.... .| .     .. |... .|.|| |  .      | |..|.|   .|     | ..|          ||||  .| .  ..||             
ldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgp...le....itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------CCQIMENGvqkcgryfpdetgatenygfaevqlL----------EkhemlnghlltrkieltsgTWKHSDDDPPIRTITHFQFlKWKEgEGL
         .....||                                    .                   .. ....... . |.....  .   .. 
daAlgKtpllildgng.........................neptaadlellk...................eelydpelferlgikylri.pvpD.gsa

EGEMSMDAFNYVNHRTrNNLDPIIVHSSLGTGRACAFVGAEYMFQMIntkKCgTARFFQVDFRTKRLgALQNGKQLFWVQNMAFELLIKKL
  .  .|.|  . ..  ..  |..|| . | ||.. || | |.       .. ...    |.| ||  .  |  .. . ... |.| ... 
plledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRp.inpnpgfieqleqyefilealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 446-685 1.7e-22 74.9 In-house 50-279 (281) alignment 
Range on Protein: 446-685
Range on HMM: 50-279/281.0
VQAWDSTSYLV------DDTHFIHASTVTApgKEYIGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGaTENY
. |.| |   |       .| .| |. | .   .   . |..|.|        |.. ..||.|||..... .||  . .|.|  || ||.||..  . .|
ivaYDatrvkvtpneenkntDYinanfvpg..ykgekeyiatqgPv.......PaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns.elky

GFAEVQllEKHEMLNGHLLTRKIELTSgtwkhsdDDPPIRTITHFQFLKWKEGEGLEGEMSMDAF-NYVNHRT-RNNLDPIIVHSSLGTGRACAFVGAEY
|   |.   ..|  . . ..||..|.        .. . |.........| .    .  . .  | . |.. | ...  |...| | | ||. .... . 
gdvtvk..staeeekatyierkfkler.......esgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr

MFQMINTK-KCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKK
... .... .    .    ..| .|   .|   |  .|  .  . | |.
lvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN13_pd Subfamily PTPN13 449-682 3.8e-23 77.1 In-house 49-269 (273) alignment 
Range on Protein: 449-682
Range on HMM: 49-269/273.0
WDSTSY-LVDDTHFIHASTVTAPGKEYIGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATEN-YGFAEVQL
.| |   | |.. .| || . .|  .   ..|.|| |.       |.| . ||.|||. .|. ..|  .  |.|  || ||.|.... .   ..  ||.|
ydetrvklgdeggyinaslikvpvgkdeyeyiacqGPl.......PetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevel

LEKHEMlNGhLLTRKIELTSGTWKHsdddppIRTITHFQFLKWKEGEGLEGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKK
|.  .. .| .  |.....    ..       | ..|..| || . .     ...  |     | ...  ||.|| | | ||. ...  . ....|. .|
lkvqkl.dg.fvvralavkdsesge......srevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk

CGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELL
    .    ..| .| | .|  .|  .| . . |.|
efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 455-687 1.7e-21 71.6 In-house 62-277 (288) alignment 
Range on Protein: 455-687
Range on HMM: 62-277/288.0
LVDDTHFIHASTVTApGKEYIGKAIICQAPFddKekGhpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHemln
| ||..|  |. | .  ..|  . | .|||.  .  |   | | .|.|. ..   |.|| |...| | .|   ||| . | .  .|    .  .|.    
lsddpdfyiaanvvs.sakykrrlicaqaPl..n..g...tieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr....

gHLLTRKIELTSGTWKHSDDDPPirTITHFQFLKWKEgEGLEgEMSMDAFNYVNHRtRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQ
   . . ....    ..  ...    . .  .|.|.. .|.  |  .  .. ..   ..   ||.|||| |.||. ...    . ...  .   . | . 
.adidklvkvsllriskegeekv..ivkilhlleWdd.dgvP.enylsplrllevl.kslqkPivvhssaGvGrtgtlililialeslrlddflgirsll

VDFRTKRLGALQNGKQLFWVQNMAF-ELLIKKLK
   | .|  |.|  .|  .|  . . |||.|| |
aklreerfkaiqtemqylyvhrcvleelllkkyk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 456-681 4.3e-23 76.9 In-house 71-282 (305) alignment 
Range on Protein: 456-681
Range on HMM: 71-282/305.0
VDDTHFIHASTVTapGKEYIGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMlNG
.||...| || |   | .   | |. |.|..       .| . |||...... . .|| ....|.| .|| .|.|.... ....|  .|.| ..... ..
lddsdyinasyvd..gykrkkkyivaqgPlk.......ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekta.sd

hLLTRKIELTSGTWkhsddDPPIRTITHFQFLKWKE-GEGLEGEMSMDAFNYVNHRTRNNLD-PIIVHSSLGTGRACAFVGAEYMFQmiNTKKCGTARFF
 ...||....         |   ||....|. .| . |   .    .. .. |... ... . |..|| | | ||. .|.  . ...    || ..  .|
.yieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdiale..rlkkEevvdvf

QV--DFRTKRLGALQNGKQLFWVQNMAFEL
.|    |.||....|. .|   . ..  ||
evlkqlRskrmkmvqtldqYvflhdaldel
DSPc_SM00195 457-681 6.7e-42 139.0 In-house 52-261 (263) alignment 
Range on Protein: 457-681
Range on HMM: 52-261/263.0
DDTHFIHASTVTAPgkEYIGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLnGH
... .|.|. .. .  ..  | |..|.|.       |.| |.||||||... ...|| .. .||| .|| ||.|.| | .|..|  .|.| |....   .
egsdYINAnyikga..nkkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk.de

LLTRKIELTSGTWkhsdddPPIRTITHFQFLKWKEGEGL-EGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQV
. .|..|||  .          |..|..|. .|.. .   . .  .. ...|.......  ||.||.| | ||...|| .... . ....|         
iilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

DFRTKRLGALQNGKQLFWVQNMAFEL
 .|..| |. |. .|. .. ... |.
elRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 457-681 6.7e-42 139.0 In-house 52-261 (263) alignment 
Range on Protein: 457-681
Range on HMM: 52-261/263.0
DDTHFIHASTVTAPgkEYIGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLnGH
... .|.|. .. .  ..  | |..|.|.       |.| |.||||||... ...|| .. .||| .|| ||.|.| | .|..|  .|.| |....   .
egsdYINAnyikga..nkkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk.de

LLTRKIELTSGTWkhsdddPPIRTITHFQFLKWKEGEGL-EGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQV
. .|..|||  .          |..|..|. .|.. .   . .  .. ...|.......  ||.||.| | ||...|| .... . ....|         
iilrtleltkegk......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivk

DFRTKRLGALQNGKQLFWVQNMAFEL
 .|..| |. |. .|. .. ... |.
elRkqRpgmvqtleqYlfiyeailey
subfamily_PTPN12_pd Subfamily PTPN12 457-688 5.4e-25 82.9 In-house 66-283 (290) alignment 
Range on Protein: 457-688
Range on HMM: 66-283/290.0
DDTHFIHASTVTAPGKEYigKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGh
..  .| |. .  . ..   . |  |.|.       |.| . ||||.|... . ||| |...|.| .|| ||.|.|.. . ..|  ||.| |.. . .. 
egsdYinanfikgvegkl..eyiaaqgPL.......pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd.

LLTRKIELTSGtwkhsdddPPIRTITHFQFLKWKEGEGLEGEM-SMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKC-GTARFFQ
.| | ....             |... |.. .| . .  ...   ..  . |... ...  |..|| | | ||. . .  .|. ......|   .   |.
flirtLkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfd

V--DFRTKRLGALQNGKQLFWVQNMAFELLIKKLKM
.  ..|..|  . |  .|   | .   ||. |.|..
lvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_Ptp69D_pd Subfamily Ptp69D 457-673 5.9e-24 79.7 In-house 74-277 (307) alignment 
Range on Protein: 457-673
Range on HMM: 74-277/307.0
DDTHFIHASTVTAPgkEYIGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtgATENYGfaEVQLLEKHEMLNGH
.|. .| || . .   .   | |. |.| .        | . ||||...   | .||  .. |   .|| .|.|.|   . .||  ..     .|   ..
edsdYinasfikgy..kekkkfiaaqdPvea.......tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg..dilvklvseekhsd

LLTRKIELTSGTwKHSDDDPPIRTITHFQFLKWKEGEGLEGEMSM-DAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQV
   |.....    ..| . .  | .. .... ||. .  |   .. .  . |..  ..|  ||.|| |.|.||.  ||  . ..| ... ..     .  
yiiReldvskkk.eesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvk

DFRTKRLGALQNGKQLFW
| | .|   .|. .|  .
dLrsqRnllvqsleqYvf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 457-697 1.9e-20 68.2 In-house 46-273 (290) alignment 
Range on Protein: 457-697
Range on HMM: 46-273/290.0
DDthFIHASTVTAPGKEyigKAIICQAPFDDKEKGHPDTRESFWRMVWDTRATYVVMCCQIMENGVQ----KCGRYFPDETGATENYGFAEVQLleKHEM
||  .|||. || |      . |. |.|  .  . .  | |.|| |. . ... ||| |. .|.  .     | .|.|.. |   ...  .|.   |. .
dd..yiHAnrvtcpngl...rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC..kske

LNGHLLTRKIELTSgtwkhsdDDPPIRTITHFQFLKWKEGEGLEGEMSM-DAFNYVNhrtrNNLDPIIVHSSLGTGRACAFVGAEYMFQMIN-TKKCGTA
 .  . ||.....        ||    |.|| ..  |.. .  | . .. .. ..|.    ..  |.|||   |  |  |.   .  .|.|  |..  . 
keddvetRelvvkf.......ddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkl

RFFQVDFRTKRLGALQNGKQLFWVQNMAFeLLIKKLKMHHLKFEMEE
.    . | .|  |... ..| .|   .. ||... ...  . | |.
edvlkalrkqralaitsalelafvdagiv.llaievldqfaeeetek
subfamily_CG42327_pd Subfamily CG42327 457-593 7.7e-14 46.1 In-house 54-175 (319) alignment 
Range on Protein: 457-593
Range on HMM: 54-175/319.0
DDTHFIHASTVTAPGKEyIGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGH
| .....|| |  . .      | .|.. .       |.  .|||.||. ..  .|  ... |.|...| .|.| . .  ..  . ....  |.   . .
dkdeyldasyvrGydda.pnsyiaaqvsle.......dsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdr

LLTRKIELtsgtwKHSdDDPPIRTITHFQFlKWKEGE
 ..  . |     |.  |.   | .||. . || | |
yaistlll.....krv.dkeesrelthywy.kwleae
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 458-711 2.3e-23 77.8 In-house 75-308 (319) alignment 
Range on Protein: 458-711
Range on HMM: 75-308/319.0
DTHFIHASTVTAPGKEyiGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETgaTENYGFAEVQLLEKHEMlNgHL
.. .| || . .  ..   | |  ||| .       .| | ||||||. ..  ||| ... |..  |. .|.|.|.   |.||   |.|.|..|. . ..
gsdyinasfidgyqer..ekfiatqaPle.......ntiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeel.e.dy

LTRKIELtsgTWKHSDDDPpiRTITHFQFLKWKEGEGLEGEM-SMDAFNYVNHRTRN-NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQV
  ||..|     | |. .   |...|||...| . .  |  .  .| .. ... ... .  ||.|| | | ||  .|.  . |.. ..         .  
iirklkl...nkkssevet..RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvs

DFRTKRLGALQNGKQLfwvqNMAFELLIKKLKMHHLKFEMEEQWNFLKNYSNKETD
  ||.|    |. .|     .. .| |.. ... . ..|...  . ||. ..|..|
rlRtqRnimvqrpeqY....kfiyealleaveagdteievqdlrdrlkqlaekvad
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 458-682 9.2e-22 72.6 In-house 83-290 (298) alignment 
Range on Protein: 458-682
Range on HMM: 83-290/298.0
DTHFIHASTVTAPGKEYigKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtgATENYGFAEVQLLEKHEmlNGHL
.. .| || . |  ..     |..|||.       . | | |||||..  .. .||  .. | .  |. .|.|||   .|.||  .|.||.|.|   . |
esdYiNAsflhaykgrn..afiatqaPl.......tetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskee..fadl

LTRKIELTSGTWKHSdddppiRTITHFQFLKWKEGEGLEGEMSMDA-FNYVNHRTRNNL-DPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQV
 .||..... . ...      |.. ...| .| .    | . |. .  . |.  ....   |.||. | |.||. .|.  . ... .....    .    
ivrklkvskkkeeke......revrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvk

DFRTKRLGALQNGKQLFWVQNMAFELL
 .|.|| ||.|  .|  .. ..  | |
vlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN14_pd Subfamily PTPN14 458-667 2.9e-18 60.9 In-house 75-281 (300) alignment 
Range on Protein: 458-667
Range on HMM: 75-281/300.0
DTHFIHASTVTAPGKEYIGKAIICQAPFddkEkghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGHL
.| .| ||.. ..      . |..|.|    |     | . ||.|||..  . .||  .. |.| .|. .|||...   ..  | . .. .|     . .
stgyinassikvsvggkersyivaqgPl...e....ltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsv

LTRKIELTSGTWKHSdddppiRTITHFQFLKWKEGE---GLEGEMS-MDAFNYVNHRTRNNLD------PIIVHSSLGTGRACAFVGAEYMFQMINTKKC
 |....|     |.       ||. |.|.  | . .    ..| .| .. .. | ..| .. .      |..|| | | ||.   . .. . . ... . 
ittglklkhlpskee......rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehnee

GTARFFQVDFRTKRLGALQN
   .      |..|   .|.
idikkvlarLreqrmllvqt
subfamily_PTPN1_pd Subfamily PTPN1 458-675 1.9e-17 57.9 In-house 55-264 (290) alignment 
Range on Protein: 458-675
Range on HMM: 55-264/290.0
DTHFIHASTVTAPGKEyiGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGaTENYGFA----EVQLLEKHEml
|...| || | ..  .   . |. | |.       |.| . ||.|||. ..  |||  ...|.. .|| .|.| .   ...  .     .|.|.....  
dndyinaslveleeak..rsyiltqGPl.......pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.ekellledtklkvkliseer..

NGHLLTRKIELTSgtwkhsDDDPPIRTITHFQFLKWKEGEGLEGEMSMDAFNYVNHR---TRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKC-G-
. .   |..||.             |.|.|| ...| .    |   ..  | .   .     ..  | ..| | | ||. .|. .. ..  |. |.    
ksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlss

-TARFFQVDFRTKRLGALQNGKQLFWVQ
   .   .. |  ||| .|  .|| .  
vdikkvllelrkyrlGliqtadqlrfsy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 458-645 2.2e-16 54.3 In-house 65-230 (281) alignment 
Range on Protein: 458-645
Range on HMM: 65-230/281.0
DTHFIHASTVTAPGKEYigKAIICQAPfdDKekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENygFAEVQLLEKHEMLNGHL
 | .|||  . .|  .     |. | |   |     .||  ||||.|.  .| .|| ||..|   .||  ||| .. .  .  | .. .  .   .|  |
stdyihanyirspflkr..gyiltqgp..kk.....etradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq..fdklsvsyedstvnksl

LTRKIELTSgtwkhsddDPPIRTITHFQFLKWKEgegLEGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTK
.| ...|.         .   | |||. . .| .    .   | . .  . .. |    | ..| | | ||. ...  |  .| | ..
vttrlnlsy........egetrlithwlwkewpd...wqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihsh
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 458-591 1.1e-09 32.5 In-house 58-176 (297) alignment 
Range on Protein: 458-591
Range on HMM: 58-176/297.0
DTHFIHASTVTAPGKEYIGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEmlnGHl
.. .| |  |. | .|   | |. | | .       .| . ||..|..     .|| ... |.| .||  |.|.  .   . |   |. | .      . 
erdyinadyvvfpdeeadlkyilaqGpls.......atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflssts...de.

lTRKIELTSGTWKHSdddPPIRTITHFQFLKWKE
   .. ||  .  .       | ..| ||| | .
.fdrviltelqliyr...sesrvvrhvqflswpd
subfamily_PTPRB_pd Subfamily PTPRB 459-685 2.8e-27 90.5 In-house 79-288 (293) alignment 
Range on Protein: 459-685
Range on HMM: 79-288/293.0
THFIHASTVtaPGKEYIGKAIICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATeNYGFAEVQLLEKHEMlnGHLL
. .| |. .  || .   . | .| |.       |.|.. ||||||..... .||  |..|.| .|| .|.|... .. .||  .|.|....|.   .  
sDYinanyi..pgynsprefiatqGPl.......petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeel..edwv

TRKIELTSgtwkhsddDPPIRTITHFQFLKWKEGEGLEGEMSMDAFN-YVNHRT--RNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQV
.|.....         .  .|......|. | . .  |   .. .|   |....   ..  ||.|| | | ||. .|.  . ..| |... .     . .
irelkiek........ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgiva

DFRTKRLGALQNGKQLFWVQNMAFELLIKK
..|..|   .|. ||  ....   .|| ||
elReeRnllvqtekqYifihqcvldllrkk
0043147 (Phosphotyrosine protein) phosphatases II 459-676 3.3e-17 58.2 In-house 5-155 (172) alignment 
Range on Protein: 459-676
Range on HMM: 5-155/172.0
THFIHASTVTAPGkeYIGKAIICQAPfddkekgHPDTRESFWRMVWDTRATYVVMCCQImengvqkcgryfpdetgatenygfaevqllekhemlnghll
...|.|| .  .    . . |..|.|        . | ..||||...   |..|....                                          
sdyinasyldlyy..ipdrfiatqgp.......lrntladfwrmlkelgithivnltel.........................................

trkieltsgtwkHSDDDPPIRTITHFQFLKWKEGEGLEGEMSMDAFNYVNH-RTRNNLDPIIVHSSLGTGRACAFVGAEYMFqmintkKCGTARFFQVDF
              | ..  |.. ....| |  .     |. .........   ...  |..|| | | ||....| | .|       .. ..      .
............lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalv

RTKRLGALQNGKQLFWVQN
|.|| || ||  |. ... 
rekRpgavqnpsqyrflyy
0044763 (Phosphotyrosine protein) phosphatases II 459-682 4e-17 57.9 In-house 18-171 (178) alignment 
Range on Protein: 459-682
Range on HMM: 18-171/178.0
THFIHASTVTapgkeyiGKAIICQAPFddkekghpdtrESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGatenygfaevqllekhemlnghll
. .|.|| ..       .  .....|            .........   |..|.... .|.| .|| .|.|.|.|                        
sdyinaseil.......pglylgslpp...........addlellkelgithivnlteelelgflkcdpywpeeag........................

trkieltsgtwkhsdddppirtiTHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMintkKCgTARFFQVDF
                        ..... .  .   .  |. .........   ..  |..|| | | ||....| | .| ..    .. ..      .
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RTKRLgALQNGKQLFWVQNMAFELL
| .|  . .|  || ... .. .||
rerRp.ivpnpgqlrqLyefelrll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 459-688 1.8e-14 48.1 In-house 80-295 (305) alignment 
Range on Protein: 459-688
Range on HMM: 80-295/305.0
THFIHASTVTAPGKEyiGKAIIC-QAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENygFAEVQLLEKHEmlNGHL
...|||  | .|      | .|| | |.|.       | . || || . .   .|| |. .| |  || .|.|   |   .  .    ..|.      . 
sdyihanyvgcpmip..ekrficaqgpldq.......tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle..lksgivvenvs..gskp

LTRKIELTSGTWKHSDDDPPIRTITHFQFLKWKEGeGLEgEMSMDAFNYVNhRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMI-NTKKCGTARFFQVD
. |  |.   . . .       .. |.|. .| .  |.     . ... .    |    ||.|| | | ||. . |  ||... | . |.|     .   
merdaeiqitllnltysgdqkmsvrhlqwtewpdr.gvp.pckltslells.airgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvka

FRTKRLGALQNGKQLFWVQNMAFELLIKKLKM
.| .|  ..||  | .... . .. ...| | 
lrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 460-687 1.2e-16 55.4 In-house 74-292 (305) alignment 
Range on Protein: 460-687
Range on HMM: 74-292/305.0
HFIHASTVTAPGKEyiGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGHLLT
..|||  |..| .    . | .|||...       |   || | .. .  .. | |...| | .||  ||. . . . ..   . ..  | |  .   ..
eyihanyvstptnp..krfictqaplek.......tcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfr

--RKIELTSGTWKHSDDDPPIRTITHFQFLKWKEGEGLEGEMSMdaFNyVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMF-QMINTKKCGTARFFQVD
   | ..|             | .||. .  | .      ....  .. . ...|    ||.|| | | ||. . |  ||.. |... ..   .    . 
kdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai..le.llekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqk

FRTKRLGALQNGKQLFWVQNMAFELLIKKLK
 | .|  ..|  .| ..| .. .. . ||  
ireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 461-690 9.9e-22 72.3 In-house 69-285 (307) alignment 
Range on Protein: 461-690
Range on HMM: 69-285/307.0
FIHASTVTAPGKEyiGKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLlEKHEmLNGHLLTR
.|||  .    |    | | .| | .       .|. ||| |. . .   |.| |...| .  || .|.| | | .  .| |   .    . |  . |. 
yihanylgiaikp..kkficaqgple.......ntqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapnti.svan.lgakklap

KIELTSGTWKHSDDDPPIRTITHFQFLKWKEgEGLeGEMSMDAFNYVNhRTRNNLDPIIVHSSLGTGRACAFVGAEYM-FQMINTKKCGTARFFQVDFRT
  .|   |  . |     |||.|.|. .| . .|   .. . | | ..  .| . .|..|| | | ||. . |.  ..  .||. . |   . .  ..|.
dedlinvttlkvdwaqksrtiqhlqwenwpd.rgv.pqinltainlle.avrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrs

KRLGALQNGKQLFWVQNMAFELLIKKLKMHH
.|  |.|.  | ...  . .| .... |  .
qrhyaiqteaqylylhrvlleyflelykety
0051429 (Phosphotyrosine protein) phosphatases II 461-684 3.7e-15 51.8 In-house 6-227 (272) alignment 
Range on Protein: 461-684
Range on HMM: 6-227/272.0
FIHASTVTAPGKEYI-GKAIICQAPFDDkekghpdTRESFWRMvWDTRATYVVMCCQIMENGVQKCGRYFP----------DETGATENYGFAEVQLLEK
 |.|. |  .|.. . |. . ...| .        | ..|||. .. . ...|. .. .| | .|| || |          |..  | .||.  | ||..
yiNardvggygrvvkpgrlyrsggplpl.......taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

HEMLNGHLLTRKIELTSGTWKHsdddppiRTITHFQFLKWKEGEGLEGEmSMDAFNYVNHrtrnnLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGT
. .|. .| .  ..|.... .        |...|.... |      . .   ........       |..|| | | .|   .| . .. . ..      
ellldyilrellltlllsagea.......revmhlhytdwpdhgvpqea.llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------ARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIK
        .. .    | .| || |.  |. .... . ||| .
dYlltnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 461-669 6e-10 33.2 In-house 81-277 (310) alignment 
Range on Protein: 461-669
Range on HMM: 81-277/310.0
FIHASTVTApgkEYIGKAIIC-QAPFDdkekgHpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDeTGATENYGFAEVQLLE-KHEMLNghLL
.|||  | .   .|. ...|| | |..     |  |   ||||... ||  ... |...|.|  ||  |.|   | || ||   |  |    | ..  . 
yihanyvkt...nylrstficsqgplq.....h..tiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygcirvtnlsesseefe..ic

TRKIELTSgTWKHSDDDPPIRTITHFQFLKWKEG--EGLEGEMSMDAFNYVNHRTRNnlDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVD
   . .        |..|        ...|| .    |.  |      . .  . |    | .|| | | .|  . |  .. .. ..  .   |   . .
nlavtfvp.dnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevkte

FRTKRLGALQNGK
.. .|.   |.  
llksraiciqtel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 462-689 5.1e-28 92.7 In-house 78-290 (301) alignment 
Range on Protein: 462-689
Range on HMM: 78-290/301.0
IHASTVTAPGKEYigKAIICQAPFDdkekghpDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGHLLTRK
|||  . ..|.    . |. |.|..       .|.| || |.       .|| .| .|. ..||  |.| ... . . |  .... .|. .|| ..  |.
ihanwiptsGhph..rfiatqgPlk.......ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrt

IELTSGTWKHsdddpPIRTITHFQFLKWKEGEGLEGemSMDAFNYVNHrTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKR
.|..  | |      . ||.||.|. .| . .  ..   .. |. ..   ..  .||.|| | | ||. ||.|.||. . .....         ..| .|
levedstgkf.....atrtvthyqysewtdrgvPks..haelfdlmel.vkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehr

LGALQNGKQLFWVQNMAFELLIKKLKM--H
  ..|. .||.|..  .   |||.  .  .
wngvqtnsqlywmtlGtvyrlikeygfdmk
0051082 (Phosphotyrosine protein) phosphatases II 462-662 1.5e-12 42.8 In-house 6-133 (151) alignment 
Range on Protein: 462-662
Range on HMM: 6-133/151.0
IHASTVTaPGkeyigkAIICQAPFDdkekghpdtreSFWRMVWDTRATYVVMCCQIMENGvqKCGRYFPDETgatenygfaevqllekhemlnghlltrk
|..| || .|       .....| .            |......   ...|.... .|.|  .| .|.|..                             
infsyvt.gg......lyrsggpla...........dflellkelgiktivnlrseeerg..ycpeylpelg............................

ieltsgtwkhsdddppiRTITHFQFLKWKEGEgleG----EMSMDAFNYVNHrtrNNLDPIIVHSSLGTGRACAFVGAEYMFQMintkkcGTARFFQVDF
                 ....|...| |..          .  .........   ..  |..|| | | ||  ..|..  | ..       ..     ..
.................ievlhipildwpdpg...lplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeey

RTKRL
| || 
rlkrp
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 473-680 2.3e-24 80.8 In-house 72-264 (283) alignment 
Range on Protein: 473-680
Range on HMM: 72-264/283.0
EYIGKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtgATENYGFAEVQLleKHEMLNGHLLTRKIELTSGtwkHS
.   | ||.|.|.|.       |.  ||.||.| ..| .||  ...|.  .|| .|.| .   .|.||   | |  ..|. .  .  ... |       |
kqdkkyiiaqsPldr.......tvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr..GsedyGeftvtl..rkettsnsfiikelllrvn...ss

DDDPPIrtITHFQFLKWKEGEGLEGEMSMDAFNYVNH-RTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQL
  .  .  ..|.|.  | | .      |.  || |   .|...  ||.|| | | ||. .|..|    . . |.            | .| .|.|.  | 
akstll..lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqy

FWVQNMAFE
  | ....|
klvhelvle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 476-633 4.4e-11 37.0 In-house 85-244 (301) alignment 
Range on Protein: 476-633
Range on HMM: 85-244/301.0
GKAIICQAPFDDkekghpdTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNG--HLLTRKIELTSG-----T
 | |. |.|..        |   |||..|. . . .|| ..  |.  .|| .|.|. .  .|..|. .|.| ... . .     |. ||. .|.      
kkfiaaqgpmkk.......tlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyier

WKHSDDDPPIRTITHFQFLKWKEgEGL--EGEMSMDAFNYVNHRTRN-NLDPIIVHSSLGTGRACAFV
  . . |   .... .|  .| . .|.  |  . . . . | ||..  .  |..|| | . .|.  ..
kfkvksdksswdvlqlqvtdWpq.dGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYc
0036282 (Phosphotyrosine protein) phosphatases II 477-676 1.2e-19 66.1 In-house 18-164 (174) alignment 
Range on Protein: 477-676
Range on HMM: 18-164/174.0
KAIICQAPFDdkekghpdtresFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDetgatenygfaevqllekhemlnghlltrkieltsgtwkhsDDDP
. |..|.|..            ||.|... . |.|||... .|.|  || .|.|.                                         . . 
rliagqgpla............fwemlkelgittvvmlleekelglykcinywpe.........................................lred

PIRTITHFQFLKWKEGEGLEGEMSMDAFNYVNHRTRN-NLDPIIVHSSLGTGRACAFVGAEYMFQMINtKKCGTARFFQVDFRTKRLGALQNGKQLFWVQ
. |.. ....| |  ..  . ..  .....|..   . .  |..|| | | ||. ..|.| .| ...   .   |  .    |..| |. |.  |. ...
lerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

N
 
y
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 479-683 1.4e-22 75.1 In-house 92-281 (318) alignment 
Range on Protein: 479-683
Range on HMM: 92-281/318.0
IICQAPFddkekghPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETgaTENYGFAEVQLLEKHEMlnGHLLTRKIELTSgtwKHSDDDppi
| .|||        |.| | ||||||.  .. .||  |..|.| .|. ||.|..   ...||   |.| |. |.  .... |....|    .....    
iaaqaPl.......petieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevel..sdyvlrefkvtr...teeees...

RTITHFQFLKWKEGEGLEGEMSM-DAFNYVNHRT-RNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQN
|..  ... .| .   .|  .|. |    |..   ... .||.|| | | ||.  |.  . . . |.  .      .   .|..|    |  .|  .. .
rqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiyd

MAFELLI
.  | |.
vlleala
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 487-683 1.1e-15 52.6 In-house 96-285 (297) alignment 
Range on Protein: 487-683
Range on HMM: 96-285/297.0
DKEKGHPDTRESFWRMVWDTRATYVVMCCQIMEnGVQKCGRYFPDETGATenYGFAEVQLLEKHEMlNGHlLTRKIELTSGTWKHSdddppiRTITHFQF
 ...  ..| . ||.||.| ... .||  .  | . .|| ||..|.. .|  .|   |.||  .|  .|  . |..|.| |  |        | .  .||
ttqmPmkatvadfWamvldeqvstivmlnddne.rdkkcaryWsdkgvtt..fGdvsvvllsvser.eGf.ikrelevtkgkakar......rvvkqyqf

LKWKEGEGLEGEMS---MDAFNYVNHRTRNNLD-PIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELL
..| . .  . .     ..  . |..   .| . |..|| . | ||.  ..  . .   .. .|      .   .| .|   .|  .|  .| ..  | |
veWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

I
.
l
0046846 (Phosphotyrosine protein) phosphatases II 488-682 1.4e-19 66.0 In-house 28-173 (176) alignment 
Range on Protein: 488-682
Range on HMM: 28-173/176.0
KEKGHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDetgaTENYGFaevqllekhemlnghlltrkieltsgtwkhsdddppirtitHFQFL
.  ..|.| ..|..|... . |.||.... .| |  || .|.|.     |..|.                                         ....|
tqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi.........................................qylhl

KWKEGEGLEGEMSMDAFNYVNHRTRNNlDPIIVHSSLGTGRACAFVGAEYMFQmintKKCGTARFFQVDFRTKRL-GALQNGKQLFWVQNMAFELL
 | ..   . |  ........ . ...  |..|| | | ||....| |  .      .|. ..      .| .|  ||.|. .|. ... .. .||
pwpDhgvpdlelllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 491-686 5.9e-14 46.2 In-house 99-292 (302) alignment 
Range on Protein: 491-686
Range on HMM: 99-292/302.0
GHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGHLLTRKIELTSGTWKHS-DDDPPIRTITHFQFLKW
   .|.| .| .. . . . ||  |...|.. .||  |. |. | . ..|   |. .. .. |.     ... | .  .| .   .   .|.  ..|  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

KE-GEGLEGEMSMDAFNYVNHRTRNnldpIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIKKL
 . |   | ....| ... .   .|    ..|| | | ||. ..|   |  |.  .||        .  |. | ||.|. .|| ..  .    |..| 
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmeka
subfamily_ptpA1_pd Subfamily ptpA1 491-642 1.8e-11 38.4 In-house 97-256 (418) alignment 
Range on Protein: 491-642
Range on HMM: 97-256/418.0
GHPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGA---------TENYGFAEVQLLEKHEMLNGHLLTRKIELTSgtwkhsddDPPIRTI
  |.|   ||||||. |.  .||  .  ||   || ||.|.. |           | .|   |.|.|  .  .  ..||.| ||         .   | |
plpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltf........egetrdi

THFQFLKWKEGEGLEGEMSMDAFNY-VNHRT------RNNLDPIIVHSSLGTGRACAFVGAEYMFQMI
|..|.  | . .  .    .  . . .  |        .   ||||| | | ||. .|. |  |.. .
tqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 492-679 1.8e-26 87.9 In-house 99-276 (288) alignment 
Range on Protein: 492-679
Range on HMM: 99-276/288.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtGATENYGFAEVQLLEKHEMlnGHLLTRKIELTsgtwKHSDDdppiRTITHFQFLKWKE
 .|| . ||..|...... .||  ...|.| .||..|.||. .  .|||  .|.|.|..|.  .. ..||..|     |. ..    ..||..|.| | .
ladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskel..edfvlrkllle....kkkte....leitqyqylaWpd

GEGLEGEMSMDAF-NYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAF
 .  | .. . .. . |.    ... ||||| | | ||.  |. .. . .......      .   .| .|    |. ||  .. ..  
hgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRG_pd Subfamily PTPRG 492-684 2e-24 80.8 In-house 100-289 (563) alignment 
Range on Protein: 492-684
Range on HMM: 100-289/563.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDetGATENYGFAEVQLLEKHEMLNGHllTRKIELTSGTWKHSDDDPPIRTITHFQFLKWKE
 .|| . ||||.|. ... .||  .. |.| .|| .|.|     .|.||  .|.| |.. .      .|.. .     |. ..    ........ || .
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalyt..vrtlviknlklkkkkqcdteklvrqyhytkWPd

GEglEGEMSMDAFNYVNHRTRNNLD---PIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLIK
      | |.   ..|... . | .   ||.|| | |.||.  ..  . . . |....      |   .|..|   .|.  |  .. .   |..  
hg..vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN6_pd Subfamily PTPN6 492-650 3.9e-23 76.9 In-house 107-262 (306) alignment 
Range on Protein: 492-650
Range on HMM: 107-262/306.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATEnYGFAEVQLLEKHEMLNGHLltRKIELTSGtwkhsDDDPPIRTITHFQFLKWKE
 ..| . ||||||.  .. .||  . .| | .|| ||.|||.  .| ||  .|. ...... .  |  |.. ..       ...   |.. ...| .| .
lettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYil..Relsvskk.....kkkkeerevfqyhfksWPd

GEG-LEGEMSMDAFNYVNHRTRNNL----DPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTA
     . .. .| .. ||.....       ||.|| | | ||  .|.  . . ..|..|.. . 
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad
subfamily_PTPRK_pd Subfamily PTPRK 492-680 4.1e-23 76.7 In-house 95-275 (314) alignment 
Range on Protein: 492-680
Range on HMM: 95-275/314.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETgatENYGFAEVQLLEKHemLNGHLLTRKIELTSgtwkHSDDDPPIRTITHFQFLKWKE
 ..| . |||.|.| ... .||  ...|.|  || .|.|..|   | ||  .|.|.| .  |.  |..|   ..      .     ||.. .||||.| .
lqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt...evygdikvelvete..llaelvvrifrvek....largqeeirevrqfqflgWpd

GEGLEGEMSMD-AFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFE
 .    . ..      |.. . ..  .|.|| | |.||. .|.  . . .||....     .   ..|...   ..  .|  .. ....|
hdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 492-709 1.8e-19 65.3 In-house 77-278 (284) alignment 
Range on Protein: 492-709
Range on HMM: 77-278/284.0
HPDTRESFWRMVWDTRATYVVMCCqimengVQKCGRYFPDETGATENYGFAEVQLLEKHEMlnghLLTRKIELTSGTwkHSDDdppIRTITHFQFLKWKE
 ..| . ||||.|. ... .|.         .|| .|.| ..  .|. .  .|...|. |        |.|||.  .  .  |   ||.|. | || | .
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee....yvvrdielsedg..kekd...irkirqfhflgwpd

-GEGLEGEMSMDAFNYVNHRT--RNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMafelLIKKLKM
 |    .   |   . |.| |   |.  .|.|| | |.||. ...  . ...... .|      |  |.| .|   .|.  | ...       |...  .
vgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa....lleehlf

HHLKFEMEEQWNFLKNYSNKE
 |    . .   .|.. ||| 
ghsdvalpdfpayleelsnks
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 492-709 2e-19 65.1 In-house 113-314 (319) alignment 
Range on Protein: 492-709
Range on HMM: 113-314/319.0
HPDTRESFWRMVWDTRATYVVMCCqimengVQKCGRYFPDETGATENYGFAEVQLLEKHEMlnghLLTRKIELTSGTwKHSDddppIRTITHFQFLKWKE
 ..| . ||||.|. ... .|.         .|| .|.| ..  .|. .  .|...|. .        |.|||.  . |. |    || || | || | .
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedg.kekd....irkitqfhflGwpd

-GEGLEGEMSMDAFNYVNHRT--RNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMafelLIKKLKM
 |    .   |   . |.| |   |.  .|.|| | |.||. ...  . ...... .|      |  |.| .|   .|.  | ...       |...  .
vGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysa....lleehlf

HHLKFEMEEQWNFLKNYSNKE
 |    | .   .|.. ||| 
ghsdvampdfpayleelsnks
subfamily_PTPN23_pd Subfamily PTPN23 492-633 3.7e-18 60.3 In-house 92-230 (288) alignment 
Range on Protein: 492-633
Range on HMM: 92-230/288.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMlnGHLLTRKIELTSGTWKHsdddppIRTITHFQFLKWKE
 . |   ||.||.. ..  .||  .  | | .|. ||.| ..|.|...|  .| | ...|.  ..   |...|.    ..      .....| |. .| |
lqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret..ethvervlkletldada......vksvshlqltsWpe

-GEGLEGEMSMDAFNYVNH----RTRNNLDPIIVHSSLGTGRACAFV
 |     |  .. .. |..    . |.   |..|| | | ||. .| 
lGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 492-680 7e-18 59.6 In-house 101-277 (315) alignment 
Range on Protein: 492-680
Range on HMM: 101-277/315.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtgateNYGFAEVQLLEKHEMLNGHLLTRKIeltSGTWKHSdddppIRTITHFQFLKWKE
 . . . |||.|..   . .||  ...|.  .|. .|.||.     .  . .. .  | |  | ..  | .   | . .       ||..  ...  | .
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kviyGkitvtrkseevnteytvrtl...svvfgdn.....irevvqlhytswpd

GEGLEGEMS-MDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFE
 .  .  .. |. .  |.    |.  .|.|| | | ||. .|.  . ... .....      |    | .| ...|  .|  .. .. .|
mgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 492-683 2e-17 58.0 In-house 96-278 (315) alignment 
Range on Protein: 492-683
Range on HMM: 96-278/315.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEmlNGHLLTRKIeLTsgtwKHSDDdppIRTITHFQFLKWKE
 . . . |||||.....| .||  .  |.   || .|.||. . . ..|  .|.||. .   ..   .||.  |    ..|..    ||.| ||| .| .
lkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslea..dtdgvarkl.vt....rksee...srtvtqfqftewPd

-GEGLEGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLI
 |   .    .     |    ...  ...|| | |.||.  .. .. . . |. ..      |   .|.||   .|  ..  .. .   | | 
kGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 492-652 4.1e-14 47.4 In-house 100-259 (325) alignment 
Range on Protein: 492-652
Range on HMM: 100-259/325.0
HPDTRESFWRMVWDTRaTYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMlNGHlLTRKIELTSGtwkhsdDDPPIRTITHFQFLKWKE
 ..| . .||.| | | . ||.   ....| ..|  |.|.| | . ..|  ||.|    |.   . . |....         ..   |..  ||.  |..
ltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdy.vhrvldvkqv......kkGetrsvkqfqlqswdd

-GEGLEGEMS---MDAFNYVNHRTRN---NLDPIIVHSSLGTGRACAFVGAEYMF-QMINTKKCGTARF
 |           ..  . |. | .       ||.|| | | ||. .|.    .  ..|.  .     |
mGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 492-683 1.1e-08 28.9 In-house 97-237 (392) alignment 
Range on Protein: 492-683
Range on HMM: 97-237/392.0
HPDTRESFWRMVWDTRATYVVMCCQIMENGvqkcgryfpdetgatenygfaevqllekhemlnghlltrkieltsgtwkhsdDDPPIRTITHFQFLKWKE
.. . . |||||.. ..| ..|  .. |                                                           ||.. |.| .| .
naaslddfwrmvfqenvttiamvtklkegd....................................................kgddartvaqfhftewPd

GEGLEGEMSMDAF-NYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLI
 .  .   |.  | . |.    .   |.|.| | | ||.   .  . .    .. .      | .. | ||   .|  .|  ..    .| |.
kdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_PTPRD_pd Subfamily PTPRD 493-683 2.3e-29 97.5 In-house 101-282 (564) alignment 
Range on Protein: 493-683
Range on HMM: 101-282/564.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtGaTENYGFAEVQLLEKHEMLNghLLTRKIELTSGTwkhsddDPPIRTITHFQFLKWKEG
..| | ||||||. . . .||  .. |.| .|| .|.|.. | ||.||  .|.| |..|. .     |...|.  .      .   |....|.| .| . 
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeelad..yeirtfklkkkk......ssesreVrqFhFtsWPdh

EG-LEGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLI
    ...  .|  . |.. ....  ||.|| | | ||  .|.  ..| . |...|    . .    |..|    |. .| ... ..  | | 
gvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 493-678 1.2e-22 75.2 In-house 74-260 (270) alignment 
Range on Protein: 493-678
Range on HMM: 74-260/270.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMLNGHLLTRKIELTsgTWKHsdddppIRTITHFQFLKWK-E
| | .|||||.|....| .||  ...|.| .|| ||.| |.. . .. . ... |  .|  .   ......|.  .. .      .| ..||.. .|  .
pttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekge......errlvHfwyntWpdh

GEGLEGEMSMDAFNYVN-----HRTRNNL---DPIIVHSSLGTGRACAFVGAEYMFQMINTK-KCGTARFFQvDFRTKRLGALQNGKQLFWVQNMA
|   | . |... . ..     .|....|   .|..|| | | ||.  ..  .......... |. ...  . . | .|   .|  .|  ....  
gvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiie.elRkdRmalvqhpeqyeflykav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 493-679 1.2e-22 75.1 In-house 101-280 (290) alignment 
Range on Protein: 493-679
Range on HMM: 101-280/290.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDEtgATENYGFAEVQLLEKhEMLNgHLLTRKIELTSgtwKHSDddPPIRTITHFQFLKWKEG
..|   ||...|. . | .|| ..|.|.| .||  |.||.   |..||  ...||.  |.|| .  .||.|...   |.|.   . ...|..|.  |.. 
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikllne.etln.eyierklevkn...knsa..gakqsvtqyqitnwdst

E-GLEGEMSMDAFNYVNHRT-RNNLDPIIVHSSLGTGRACAFVGAEYMFQmiNTKKCGTARFFQV--DFRTKRLGALQNGKQLFWVQNMAF
.   . . .. ... ...   ..   .|.|| | . ||.  |. |.   .   .|. |    |||    |... | .|  .|.  . .. .
gkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin..kcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 493-682 2e-20 68.1 In-house 62-242 (250) alignment 
Range on Protein: 493-682
Range on HMM: 62-242/250.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQkCGRYFPDEtgATENYGFAEVQLLEKHEMlnGHLLTRKIELTSGTWKHSdddppiRTITHFQFLKWKEG
..| | |||||..  .. .||  .. |.. . . .|.| |   .|.||   |.||.|.|.  . . .||. |.. . ...      |.. ...|. | . 
qatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaekyGdvtvsllskeef..adytkrklklskakkade......rivrqlhfvvWPdk

EGLEGEMSM-DAFNYVNHRTRN-NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELL
   |   .. .  . |.   .. .  |.||. | |.||. ||.  . ... ....|    . .   .|..| .|..  .|  .| ... . |
gvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPRN_pd Subfamily PTPRN 493-640 6e-20 66.1 In-house 110-249 (297) alignment 
Range on Protein: 493-640
Range on HMM: 110-249/297.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETgaTENYGFAEVQLLEKHEMLNGhLLTRKIELTSgtWKHSDddppIRTITHFQFLKWKEG
..|  .||.|||.  .. .|. ... |.||..| ||.|||   .| |.. ||.|. .|   .   | | . |     . |.     ||.| | || |.| 
astvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG..sevyhiyevhlvsehiwcdd.ylvrsfylkn..lqtse....trtvtqfhflswpee

EGLEGEMSMDAF-NYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQ
.      |.  |   ||   |    ||.||.| |.||. ...  . . .
gvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln
subfamily_PTPN9_pd Subfamily PTPN9 493-670 6.4e-20 66.4 In-house 95-278 (297) alignment 
Range on Protein: 493-670
Range on HMM: 95-278/297.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMlnGHLLTRKIELTsgtwkHSDDDpPIRTITHFQFLKWKE-
. | . ||||||. ..  .||  ...|.|  |||.|.|.|.......|. .|. .| .|.   .  .|..|..     .....  .|..|||||| | . 
kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveee..edykvrvleik.....nvkte.esrkvthfqflsWPdy

GEGLEGEMSMDAFN-----------YVNHRTR--NNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQ
|   ...  .|  .           .. ....   .  ||.|| | | ||. .|.  ..  . ....     .     .||.|  ..|  .|
GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 493-676 1.2e-19 65.5 In-house 83-262 (274) alignment 
Range on Protein: 493-676
Range on HMM: 83-262/274.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGA--TENYGFAEVQLLEKHEMlNGHlLTRKIELTSGTWKHSdddppirtITHFQFLKWK
| | . ||||.. .... .||  .. |.  ||| .||||....  .|.||  |..  .. |  |..   ||. | . . ..|        ..|. . .| 
pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiver.ndy.svrklvlkylerers........vkhywytdWP

EGEGLEGEM-SMDAFNYVNH-RTR--NNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQN
. .  .     .|  . |.. |..  ..| |..|| | | ||. .|....   . .. ..        ...| .| | .|. .|  .. .
dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 493-683 3.3e-19 63.4 In-house 96-277 (515) alignment 
Range on Protein: 493-683
Range on HMM: 96-277/515.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMlnGHLLTRKIELTSGtwkhsdDDppIRTITHFQFLKWK-E
. . . |||.|.. . | ..|  .  |.   |||.|.||  | . ..|  .|.|.  .    .  . ||.... |      ||  .||.| |.| .|  .
kasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac..tggikrkltvlkg......dd..srtvtqfhfteWPdk

GEGLEGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAFELLI
|   .    .     |   . .   |.|.| | | ||.  .. .. .   ..| .      |    | ||   .|   |  .. ..  | | 
GvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 493-672 1.2e-18 61.7 In-house 104-273 (290) alignment 
Range on Protein: 493-672
Range on HMM: 104-273/290.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLLEKHEMlNGHLLTRKIELTSgtwKhsdDDPPIRTITHFQFLKWKEG
 ||   .|||| .......|| |...|.|  || .|.|.. | .  .|   |   |...  . ..  . . .     |   |.     . |..   | . 
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk.daniikktlsvrd...k...dsGkehklkhlkikswpdk

EGLEGEMSMDAfnyVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMIN-TKKCGTARFFqVDFRTKRLGALQNGKQLF
     ....     . .  |.   |..|| | | ||. .||  |   |..   |.   .       |  ||...|   | .
svalstlallr...tlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlv.ralrnsrlnsvqvdiqyl
0049260 (Phosphotyrosine protein) phosphatases II 493-676 7.2e-18 60.2 In-house 19-144 (152) alignment 
Range on Protein: 493-676
Range on HMM: 19-144/152.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFpdetgatenygfaevqllekhemlnghlltrkieltsgtwkhsdddppirtitHFQFLKWKEG
| | ..||||...  .|..||... .|.|  || .|.                                                     ....| |  .
pntladfwrmlkelgittivmltellelgklkceqyi.....................................................qylhlpwpDh

EGLEGEMSMDAFNYVNHR-TRNNLDPIIVHSSLGTGRACAFVGAEYMFqmintkKCGTARFFQVDFRTKRLGALQNGKQLFWVQN
   . .. .. .. . ..  ...  |..|| | | ||. ..| | .|       .  ..  .   .|.|| || .|  ||.....
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 493-671 6.9e-13 43.0 In-house 90-266 (287) alignment 
Range on Protein: 493-671
Range on HMM: 90-266/287.0
PDTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFaEVQLLEKhEMLNGHLLTRKIELTsgtwkHSdDDPPIRTITHFQFLKWKEG
. |  .|||.|..||.. |..  . .|.. .|| .|.|.        |.  | ||.. .... .  .| . |      .  .    | .  ...|.| ..
aatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGy.svvlldy.dikePeygvralrli.....dl.etrearvvkqldllswPdk

EGLEGEMSMDAFN-----YV-NHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMI-NTKKCGTARFFqVDFRTKRLGALQNGKQL
      ...  |      ..   |  ..  |..|| . | ||.  ..    . ..  .. .  .|.   . .| .| . .|   ||
vlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavv.irlreyraalvqavvql
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 494-678 8.5e-21 69.2 In-house 97-274 (287) alignment 
Range on Protein: 494-678
Range on HMM: 97-274/287.0
DTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGatENYGFAEVQLLEKHemLNGHLLTRKIELTSgtwkhSDDDPPIRTITHFQFLKWKEGE
.|   ||....| . | .|| || .||  ..| .|.|.|.     .|  ...||...   | . . ||.|..      .. . . .... .|. .|..  
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee..vnagyierklevkn.....knkagdkqqvkqyqitnWdstg

-GLEGEMSMDAFNY--VNHRTRNNlDPIIVHSSLGTGRACAFVGAEYMFQmiNTKKCGTARFFQV--DFRTKRLGALQNGKQLFWVQNMA
   | . ..  ..    ..| | |  .|.|| | . ||.  |. |.   .  ..|. |.   |||    | .. |..|  .|   .... 
kvtepqtillvieemyktqrkrgn.tsivvhCsdtvGrsamfcaaattin..kckteGviDvfqvlksqriqkpgsvqtveqykfindiv
subfamily_PTPRA_pd Subfamily PTPRA 494-679 1.4e-20 68.4 In-house 112-292 (330) alignment 
Range on Protein: 494-679
Range on HMM: 112-292/330.0
DTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATenYGFAEVQLleKHEMLNGHLLTRKIELTsgTWKHSDDDPPIRTITHFQFLKWKE-G
.| | ||||.|. ... .||  .. |   .|| .|.|||   |  ||   |..  ..|..  ..  ||. ..     .. .. . | .. | |  | . |
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvt..yGnirvev..edetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvG

EGLEGEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQLFWVQNMAF
   |.   .. .. |..  ... .||.|| | |.||. .|.  . .........      |   .|..|   .|  .|  .. ..  
vPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvll
subfamily_CG7180_pd Subfamily CG7180 494-647 3.1e-18 60.5 In-house 96-255 (296) alignment 
Range on Protein: 494-647
Range on HMM: 96-255/296.0
DTRESFWRMVWDTRATYVVMCCQIMENGVqKCGRYFPDETgaTENYGFAEVQLLEKHEMLNGHLLTRKIELT--SGTWKHSDDDPPIRTITHFQFLKWKE
.| ..|||.|.|  .  ||. .. ..    ..  |.| ..   |.||  .|...|.... | .  | |.  .  . | .. . . . |....||. .|. 
etvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWel

GEGLEGE--MSMDAFNYVNHR-----TRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKC
.. .       ..  . |.        ...  |..|.|| |..|. ......   .... ...
edkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeee
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 494-658 2.3e-10 35.0 In-house 15-177 (198) alignment 
Range on Protein: 494-658
Range on HMM: 15-177/198.0
DTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLleKHEMLNGHLLTRKIELTSGTwkhsDDDPPIRTITHFQFLKWKEGE
.|   ||.|||.| . ..||  .   |       |.|    .| .||   |    |    .       . ||. |       |  | |.|.||  |||  
etladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt..ktittkpdytitaliltnnt....tappstreishyqftswkekt

GLEGEMSMD---AFNYVNHRTRN-NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFR
  .  . .    |   | ..  . .  |.||| | | | .  ||  .   .  .  |     .|.|  |
tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 494-658 2.6e-10 34.8 In-house 16-178 (199) alignment 
Range on Protein: 494-658
Range on HMM: 16-178/199.0
DTRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQLleKHEMLNGHLLTRKIELTSGTwkhsDDDPPIRTITHFQFLKWKEGE
.|   ||.|||.| . ..||  .   |       |.|    .| .||   |    |    .       . ||. |       |  | |.|.||  |||  
etmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt..ktittkpdytitaliltnnt....tappstreishyqftswkekt

GLEGEMSMD---AFNYVNHRTRN-NLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFR
  .  . .    |   | ..  . .  |.||| | | | .  ||  .   .  .  |     .|.|  |
tpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 495-690 7.6e-22 72.6 In-house 40-229 (255) alignment 
Range on Protein: 495-690
Range on HMM: 40-229/255.0
TRESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGatENYGFAEVQLLEKHEMLNGHLLTRKIELTSGTWKHSdddppiRTITHFQFLKWKEGEG
| . |....  |... ||| |   |.||.|| .||| |    |   .|.|..   . . .  | |..| .| |  |.       .|..|...  | |  .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekd..eklkladvnvtttkssadvvlrtleitstlgekkkt......htvkhysykGWiekna

LEgeMSMDaFNYVNHRTRNNlDPIIVHSSLGTGRACAFVGAEYMFQ----MINTKKCGTARFFQV--DFRTKRLGALQNGKQLFWVQNMAFELLIKKLKM
 |  .. .   .. .  |.   ...|| | | ||. ||| ||...|     ..| . .   . ..  . | || .|...  || .   | ..|.  | ..
Pe..lare.ilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgel

HH
 .
ea
subfamily_hpo-7_pd Subfamily hpo-7 496-687 3.3e-20 67.1 In-house 47-232 (263) alignment 
Range on Protein: 496-687
Range on HMM: 47-232/263.0
RESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGatENYGFAEVQLLEKHEMLngHLLTRKIELTSGTW-KHSdddppIRTITHFQFLKWKEGEG
 ..|....  |... ||| |   |.||.|| .||| |    |   .|.|..   . .    .| . .||.|    |       ..|..|...  | | ..
idkfyqtivqtktevvvmLcDfneegvekcssyfPlekd..ekqklanvnvcttkvqs..dvllktlellstlgeKkk.....thtvkhysykgWieknd

LEGemSMDAFNYVNHrTRNNlDPIIVHSSLGTGRACAFVGAEYMFQ----MINTKKCGTARFFQV--DFRTKRLGALQNGKQLFWVQNMAFELLIKKLK
 |   . . .| ..  .||   ...|| | | ||. ||. || ..|     ..| . .   . ..  . | .| .|...  || .   | ......   
pel..areilnilkv.arns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 497-650 1.8e-14 48.5 In-house 59-207 (237) alignment 
Range on Protein: 497-650
Range on HMM: 59-207/237.0
ESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDeTGATENYGFAEVQLLEKHEMlNGHlLTRKIELTS-GTWKhsdddpPIRTITHFQFLKWKEGEGL
. ||.|||. . . .||   ..|.  .|| .|.|. |   . ||   | |  | |.   .   | . |.  .| |       .| |  .||  | .    
ddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaaygvltvslkkkeef.sdy.tvrslllskrltlk......evrlihqyqftswpdrgvp

EGEMSMDAF--NYVNHRTR-NNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTA
.   ..  |  | .|.    ..  | |.| | | ||.  |.  . |..  . ||    
qqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdi
subfamily_eak_pd Subfamily eak 497-591 2.2e-09 31.2 In-house 107-191 (332) alignment 
Range on Protein: 497-591
Range on HMM: 107-191/332.0
ESFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGATENYGFAEVQllEKHEMLNGHLLTRKIELTSGTWKHsdddppirTITHFQFLKWKE
  ||.|| . ..  .|.  . .|....|  .||||.|    ..|. .|.   |. . .. | ||..||. |   |         . |...  | |
fafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve..rkefvkrniletrllelskGneth........rvlhykvfGwte
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 498-671 2.2e-09 31.8 In-house 67-230 (239) alignment 
Range on Protein: 498-671
Range on HMM: 67-230/239.0
SFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGateNYGFAEVQlLEKHEMLNGHLLTRKIELTSGTWKHsdddppiRTITHFQFLKWKEGeGLE-
 ||||.|. |   .||   ..|   .|| .|.|| |    .|    |  | | |..  ...   .    |  .        | . ...|  | .  |.  
dfwrmmwqerrcvivmltglieghkkkchqywpdsts...kycnlrvt.lrktevfadyiirtfvmsqvgqtee.......ryvyqyhftvwpdk.gvpq

-GEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQL
     .     . . .     | ..| | | ||. ||.  . |..  . .|      .    |  |   .|  .| 
yatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 498-671 2.2e-09 31.8 In-house 66-229 (239) alignment 
Range on Protein: 498-671
Range on HMM: 66-229/239.0
SFWRMVWDTRATYVVMCCQIMENGVQKCGRYFPDETGateNYGFAEVQlLEKHEMLNGHLLTRKIELTSGTWKHsdddppiRTITHFQFLKWKEGeGLE-
 ||||.|. |   .||   ..|   .|| .|.|| |    .|    |  | | |..  ...   .    |  .        | . ...|  | .  |.  
dfwrmmwqerrcvivmltglieghkkkchqywpdsts...kycnlrvt.lrktevfadyiirtfvmsqvgqtee.......ryvyqyhftvwpdk.gvpq

-GEMSMDAFNYVNHRTRNNLDPIIVHSSLGTGRACAFVGAEYMFQMINTKKCGTARFFQVDFRTKRLGALQNGKQL
     .     . . .     | ..| | | ||. ||.  . |..  . .|      .    |  |   .|  .| 
yatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy
0048076 (Phosphotyrosine protein) phosphatases II 571-680 4.7e-09 31.6 In-house 37-141 (145) alignment 
Range on Protein: 571-680
Range on HMM: 37-141/145.0
HSDDDPPIRTITHFQFLKWKEGEGLEG-EMSMDAFNYVNHRTRNNlDPIIVHSSLGTGRACAFVGAEYMFQmintKKCGTARFFQVdFRTKRLGALQNGK
 |. . . |.......| |   .  .  |. .........  ...  |..|| | | ||....|.|  |..    ...     ..  .|..| || .|  
tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lgvsleealel.vrsqrpgavpnpg

QLFWVQNMAFE
|| ...    |
qlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 572-676 3.3e-08 28.9 In-house 40-139 (144) alignment 
Range on Protein: 572-676
Range on HMM: 40-139/144.0
SDDDPPIRTITHFQFLKWKEGEGLEG-EMSMDAFNYVNHRTRNNlDPIIVHSSLGTGRACAFVGAEYMFqminTKKCGTARFFQVdFRTKRLGALQNGKQ
 . . ..|.......| |   .  .  |.  ........  ...  |..|| | | ||....| |  |.    ....     ..  .|..| || .|  |
yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klglsleealal.vrsrrpgavpnpgq

LFWVQN
| ....
lrfLle
PTPc_DSPc_SM00012 580-672 5.7e-12 41.1 In-house 1-97 (105) alignment 
Range on Protein: 580-672
Range on HMM: 1-97/105.0
TITHFQFLKWKEGEGLE-GEMSMDAFNYVNHRTRNNL--DPIIVHSSLGTGRACAFVGAEYMFQMINTKKcGTARFFQV--DFRTKRLGALQNGKQLF
|..|.....|.. .  | ..  ......|.. ....    |..||.| | ||.. || .... |...... ..  .||.   .|..| |. |.  | .
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqyl