Gene Y57G11C.6 in Caenorhabditis elegans

Synonym: CELE_Y57G11C.6, CELE_Y57G11C.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP223_AA protein Get Run
CeleP223_AA_167-435 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 159-440 7e-44 145.8 In-house 18-305 (308) alignment 
Range on Protein: 159-440
Range on HMM: 18-305/308.0
TITEGADKWVGEDVAKNWMDSIDLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKV--EKDYVNISRVEIP---LGRNIYIGQVPV
.|.    |.  .|..| ... .||  ...|||.|.|.|.. | ..  ...| . |.. |....|..  |.  . ||.| | | ..   | | . . | | 
silvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPl

KDTEETFWKAVFDKRIVSIDVIVGDEP------IEFFPKKAE-DYKNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQ
..| | ||. |.. ..  | ..   .        ...| . . ....||.........|   ||. .. .|. ..|...|.....    ||. ..|| . 
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

AIAIKEAFGLNSYLlkapADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTK
.| ..    ....|     . . .. . .| ||.| |.|| .... ....  .. . ..|| .|.||| .| .. ||. ||  ||...|.|.||
eilldflelvrksl....pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 160-449 1.1e-126 416.4 In-house 3-300 (302) alignment 
Range on Protein: 160-449
Range on HMM: 3-300/302.0
ITEGADKWVGEDVAKNWMDSIDLAEVKKEFEKLQSMKVDVEKeCKTWKANSKYNQSEDFPALDSNLLKVE---KDYVNISRVEIP-LGRNIYIGQVPVKD
..|...|||.|..||....|.| |||||||.|...||||.|| ||..|.|.|.|||||.|.|||||.|.|   ..|||.|.||.| |.|.|...|.|..|
veeekekWveeeeakklvksldtaevkkefkkidtmkvdlek.CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvd

TE---ETFWKAVFDKRIVSIDVIVGDEPI-----EFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQA
.|   |.||..||...|||....||.|..     |.||||..|||.||.|..||||||.......|..|||||.|||||...||.|..|||...||||.|
sedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

IAIKEAFGLnsYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGDKK
 .||.| ..  . .|..||.|..| |..||||||.||.|||||...... .||.| .|||||||||||||||..||.||||.||..||||||||.|..||
eliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkk

ST
..
ee
0039614 (Phosphotyrosine protein) phosphatases II 164-439 2.5e-39 130.9 In-house 13-294 (297) alignment 
Range on Protein: 164-439
Range on HMM: 13-294/297.0
ADKWVGEDVAKNWMDSIDLAEVKKEFEKLQSMKVDveKECKTWKANSKYNQSEDFPALDSNLLKVEK--------DYVNISRVEIPL--GRNIYIGQVPV
  ..  .|... ...  .   ...|||.|.|.|.|  ...  ...| . |.. |....|..  |.          ||.| | |. .   .|.... | | 
piplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

KDTEETFWKAVFDKRIVSIDVIVGDEPI-----EFFPKKAEdykNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSnsIICNVTVISNWKVDSVPVKQAI
..| | ||. |.. .. .|  .   ..      ...| . .   .||.......|||.  |..... .|| ..|.|   ....    .|  ..||   ..
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslel

AIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVT
 ..    ....| ..| .    . . .| ||.|.|.|.  ... ....  .... ..|| .|.||| || .. ||  ||  ||...|.|.|
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 164-432 6.2e-14 46.3 In-house 6-277 (303) alignment 
Range on Protein: 164-432
Range on HMM: 6-277/303.0
ADKWVGedVAKNWMDSiDLAEVKKEFEKLQSM-KVDVEKecKTWKANSKYNQSEDFPALDSNLLKV-EKDYVNISRVEIPLGRNIYIGQVPVKDTEETFW
 .|| .  .||. .|  |     .||||. |    .| |  . .  | . |.  |   ||   .|. .  |.  | .|.   ..  . |.|.  |   ||
kqkwkl..lakrtlde.daniavnefekvvsylppsvsk..nqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfw

KAVFDKRIVSIDVIVGDEPIEF------FPkKAEDYKNYGQMWINNRKVEYVS-DDVFRFSIEVLPHGCSNSIIcNVTVISNWKVDSVPVK-QAIAIKEA
. . ....  . ... |   .       || . .|. .. .  |   .   |   | . . .  .  |  .|..  |    .|  .|.| .  .  .|. 
qmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksfl.hvhhykawphnsipsdgspkfvkqi

FGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLY
. |.|.| |      ..  |  | |||| |  .  |  .. .. |   .|  .. .|  |  ||. ..|.  .|  |  
wqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
0040438 (Phosphotyrosine protein) phosphatases II 166-449 2.9e-44 147.0 In-house 1-291 (317) alignment 
Range on Protein: 166-449
Range on HMM: 1-291/317.0
KWVGEDVAKNWMDSIDLAEVKKEFEKLQSMKVDvEKECKTWKANSKYNQSEDFPALDSNLLKVE-------KDYVNISRVEIPL-GRNIYIGQVPVKDTE
|..... | ....  |   ...|||.|.|.|.| . ..  ...| ..|.. |.. .|..  |.         ||.| | |..|  .|.. . |.| ..| 
kvldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntv

ETFWKAVFDKRIVSIDVIVGDEPI------EFFPKkaEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIK
| ||. |.. .. .|  ..  |.       ...|   .....||.........|.  ...  . .|| ..|.|.| ....    .|  ..||    . ..
edFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

EAFGLNSYLLkaPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVaEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGDKKST
    ....|   . .   .. . .| ||.|.|.|. .... ....  .... ..|| .|.||| || .. ||. ||  ||...|.|.|..   ..|. 
fleavreale..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk
0043336 (Phosphotyrosine protein) phosphatases II 169-434 4.8e-42 139.7 In-house 6-277 (278) alignment 
Range on Protein: 169-434
Range on HMM: 6-277/278.0
GEDVAKNWMDSIDLAEVKKEFEKLQSMKVdVEKECKTWKANSKYNQSEDFPALDSNLLKVE-------KDYVNISRVEIPL-GRNIYIGQVPVKDTEETF
.   | ...   . . ...|||.|.|.|.  ....  ...| . |.. |....|... |..        ||.| | |. .  .|.... | | ..|.| |
dllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WKAVFDKRIVSIDVIVGDE------PIEFFPkkaEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAF
|. |.. .. .| ......        ...|   .....||.......|.|.  ||. .. .|| ..|...| ....    .|  ..||   .. ..   
wrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

GLNSYLLkaPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVaEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
 ....|   . .   .. . .| ||.|.|.|| .... ...   .... ..|| .|.||| || .. ||  ||  ||...
avreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 171-445 4.4e-48 159.5 In-house 1-288 (297) alignment 
Range on Protein: 171-445
Range on HMM: 1-288/297.0
DVAKNWMDSIDLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVEKD---YVNISRVEIPL-GRNIYIGQVPVKDTEETFWKAVFD
|..| ......|| ..||||.|...... ....  ...| . |.. |....|..  |....   |.| | |...  .|.. . | | ..| | ||. |..
dllkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

KRIVSIDVIVGDEPIEF------FPKKAEDYKNYGQMWINNRKVEYV-SDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSY
 .. .| ... ... ..      .| . .....||........||.| .||. .. .||...|...| ....  . .|  ..||   |. ..    ....
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

LLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDT--KVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGD
| ..| .   .. . .| ||.| |.|. .... ...  |  ...|...||..|.||| || .. ||. ||  ||...||| ||.   .
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0047943 (Phosphotyrosine protein) phosphatases II 174-434 9.2e-40 132.2 In-house 3-272 (273) alignment 
Range on Protein: 174-434
Range on HMM: 3-272/273.0
KNWMDSIDLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKV---EKDYVNISRVEI-PLGRNIYIGQVPVKDTEETFWKAVFDKRI
. .... .|. ...|||.|.|.|.......  ...| ..|.. |....|..  |.   . ||.| | |.  .|.|.. . | | ..| | ||. |.....
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

VSIDVIVGDEPI------EFFPKKAED-YKNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLK
  | ... ..         ..| . .. ...||.........|.  ||.  . .|. ..|...| ....    .|  ..||   .. ..    ....| .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

APADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
.| .   .. . .| ||.| |.|| .... . ..  .... ..|| .||||| .| ...||. ||  ||...
lpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 177-437 1.4e-18 62.0 In-house 15-282 (288) alignment 
Range on Protein: 177-437
Range on HMM: 15-282/288.0
MDSIDLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVEK-------DYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKR
..  . .....|...| ... . ...      | | |. ..  ..| . .|..|       ||.| | ..   ... ||  | |. || . ||. |....
ksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

IVSI---DVIV--GD-EPIEFFPKkAEDYKNYGQMWINNRKVEYVSDDVFRfSIEVLpHGCSNSIICNVTvISNWKVDSVPVKQAiaikEAFGLNSYLLK
.  |     .|  |. . .|..|. |.. ||||.. .  .... . | | | ....  .  ..  | .      |  ..||  .|    . ..| . .  
tstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlr.kllle.kkkteleitqyq.ylaWpdhgvPeska....pllellrqvkv

APADD--NAMINSQHGAGRAGYFLALAVAVHTIDTkVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
|  .|  . ..    | ||.| |.||  .......      ....|. .| ||.  |.   ||  .|  ||  |...
anqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_PTPN13_pd Subfamily PTPN13 178-435 3.7e-13 44.4 In-house 6-270 (273) alignment 
Range on Protein: 178-435
Range on HMM: 6-270/273.0
DSIDLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVE--KDYVNISRVEIPLGRNIY---IGQVPVKDTEETFWKAVFDKRIVSI
. .|  . ..||..|. .|   . |    |.| . |.  .    |   .|..    |.| | ...|.| . |   . | |. .| . ||. |....   |
kkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

DVIVGDEP---I---EFFPKKAED-YKNYGQMWINNRKVEYVSDDVFRfSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKeafgLNSYLLKAPA
 ..  .     .    ..|.....  | .... ... ||.  .. | | ...|     ..|.        .|   .|| . |  ..    . ... .   
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvr.alavkdsesgesrevahlnfvkwPdhgvPssaaellq....fvaevrrlqt

DDNAM-INSQHGAGRAGYFLALAVAVHTIDTKVaEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
|   . .    | ||.| .... |..  |. .  |  . .||...| ||   | .  ||   | ..|. .|
dagPivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN3_pd Subfamily PTPN3 178-424 9.4e-13 42.7 In-house 10-265 (280) alignment 
Range on Protein: 178-424
Range on HMM: 10-265/280.0
DSIDLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDS---NLLKVEKDYVNISRVE--IPLGR--NIYI-GQVPVKDTEETFWKAVFDKRI
....  .| ..||.|   | ... ..    .| . |.  |  . |.   .| . |.||.| . |.  ||     | ||  | |...| . ||. |.....
eglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqks

VSI---DVIV--GD-EPIEFFPKkAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNVTVIsNWKVDSVPVKQAIAIKEAFGLNSylLKA
  |     .|  |     ...|.  ||  .||.. .. .| .  .  |.|  .    .   .  | ..  . .|   .|| ..|  ..    ...  |..
slivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqyl.aWpdhgvPddsadflefvervrk..lrs

PADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYC
 ...  ..    | ||.| ...| .|.. |...  .  ..|||. .| ||   |..  || 
gkeePvvvhCsaGigrtGvlilletalalieaa.epvypldivrtmrdqramlvqtasqyk
subfamily_PTPN6_pd Subfamily PTPN6 178-437 1.1e-09 32.7 In-house 21-300 (306) alignment 
Range on Protein: 178-437
Range on HMM: 21-300/306.0
DSIDLAEVKKEFEKLQSMKV--DVEKECKTWKANSKYNQSEDFPALDSNLLKV------EKDYVNISRVE--IPLGRNIYIG-QVPVKDTEETFWKAVFD
.|.. | ...|||.|| ...   ....  . . | . |. .     | . ...      ..||.| . ..  ..  .. ||  |  ...| . ||. |..
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

KRI---VSIDVIV--G-DEPIEFFPKKAEDYKnYGQMWINNRKVEYVSDDVFR-FSIEVLPHGCSNSIICNVTvISNWKVDSVPVKQAIAIKEAFGLNSY
.     | .   |  | .  . ..|.. |. . ||.. ..| . .  .| ..| .|..   .. ..  . .     .|   .|| ..   ..    .|. 
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyh.fksWPdhgvpkdpgavLdfledvnrk

LLKAP--ADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAE--PCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
  .         ..    | || | |. . . ...| .|  .    | ..|||.|.||   |    ||  .| .. ..|..|
qeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 179-434 6.5e-16 53.4 In-house 23-290 (298) alignment 
Range on Protein: 179-434
Range on HMM: 23-290/298.0
SIDLAEVKKEFEKLQSMKVDVEKEC---KTWKANSKYNQSEDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDK
. .|.  ..||..|.|.. ..|.|.      ..| | |   |  ||||    .       | ||.| | ..   ||| .|  | |.. | | ||. | ..
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvtee

RIVSIDV---IVGD---EPIEFFPKKAEdyKNYGQMWINNRKVEYVSDdVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSyLL
 | .| .   ..     .  ...|.. .  ..||.. .. .. |  .| .    ..|  .  ...        ..|   .|| ..   ..     .    
digtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefad.livrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sq

KAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
.   .   ...  .| ||.| | |.   .  . ..     . ..|| .| .|| ||..  ||  .|   | ..
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqv.vDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 179-439 6.6e-09 30.2 In-house 15-276 (288) alignment 
Range on Protein: 179-439
Range on HMM: 15-276/288.0
SIDLAEVKKEFEklQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVEKDY---VNISRVE-IPLGRNIYIGQVPVKDTEETFWKAVFDKRI---VS
.| .. .|||..  .| .   ..  ... ||.  .. |. |  |   .|.. |    ..   |   .  | .   | |.. | | .|| .... .   | 
qiaveglkkeyr..dspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

IDVIV--G-DEPIEFFPKKAEDYKNYGQMwINNRKVEYVS-DDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKeafgLNSYLlkAPADD
.  ..  | ..  |.|| |  .   .|..  .  |....  | . . |.    .   ...|  .  . .|. |.|| .    ..    |   |     . 
lcellekGkeksaeyfPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr....llevl..kslqk

NAMINSQHGAGRAGYFLALAVAVHTIdTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVT
  .. |..|.||.| .    .|....   .    |  .... | .| .|. .  ||  ..  .|. .  |  
PivvhssaGvGrtgtlililialesl.rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
0045450 (Phosphotyrosine protein) phosphatases II 181-436 8.4e-39 129.5 In-house 25-306 (307) alignment 
Range on Protein: 181-436
Range on HMM: 25-306/307.0
DLAEVKKEFEKLQSMKV--DVEKECKTWKANSKYNQSEDFPALDSNLLKV--------EKDYVNISRVEIP---------LGRNIYIGQVPVKDTEETFW
.|. ..||||||.|..|    | ..  ...| ..|.. |....|..  |.        . ||.| | | .|         |.|.. . |.| ..| | ||
fltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFw

KAVFDKRIVSIDVIVGDEPI------EFFPKKaEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPH-GCSNSIICNVTVISNWKVDSVPVKQAIAIKEAF
. ......  |  . ....       ...| . .....||.........|.  |.. .. .|| .. |...|.....    .|  ..||   .....   
rmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfie

GLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAE--PCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
 ....| . | .   .. . .| ||.|.|.|. .. . ...      ... ..|| .|.||| || .. ||. ||  ||....|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
subfamily_PTPN14_pd Subfamily PTPN14 181-436 1.8e-12 41.9 In-house 21-298 (300) alignment 
Range on Protein: 181-436
Range on HMM: 21-298/300.0
DLAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKV------EKDYVNISRVEIPLGRN--IYI-GQVPVKDTEETFWKAVFDKRIVS
. ..| .|.|... .. | . .. . . | . |. .|.   . | ...      ...|.| |......| .   ||  | |.. | . ||. |... .  
eegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IDVIVGD------EPIEFFPKKA--EDYKNYGQMWINNRKVEYVS-DDVFRFSIEVLPHGCSNSIIcnVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLK
|  .  .        ...|||.   ..  ..|.  . .. .|  .      . .. || .   ...       .|  . ||      ..    ..|   |
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvw..hlqytDWpdhgvPeDvkgflsyLeevqsvrrk

APADD-------NAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
.             ..    |.||.|  .   . ..|...   |  |  ... .| ||   |....||  .|  |. ..|.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_PTPRD_pd Subfamily PTPRD 181-307 1.8e-06 21.9 In-house 308-448 (564) alignment 
Range on Protein: 181-307
Range on HMM: 308-448/564.0
DLAEVKKEFEKLQ-SMKVDVEK-ECKTWKANSKYNQSEDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIV
. .....||..|. . ....|.  . | . |.| |.  .  ||.|. ...       | ||.| | .|   ... .|  | |.|.| | ||. |... . 
emtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwrmvweeevk

SIDVIVGD-EPIE-FFPKKAED--YKNYGQMWINNRKVEYV
 | .. .  |..| .. .   |   ..||.. |.  | . .
iivmltkleekleeesseyysdleatkyGeitikvlkkkek
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 182-433 3.8e-09 30.6 In-house 10-268 (281) alignment 
Range on Protein: 182-433
Range on HMM: 10-268/281.0
LAEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNL--LKV------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSI
| ..|.|| .|          .     | | |.  . |.||     |||        ||.    .  |. .  ||  | | |.|   ||. ....   .|
lddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

DVIVG------DEPIEFFPKKAEDYKNYGQMWINnrkveYVSDDVFRfSieVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPaD
 ...       ..  |.||..|    .. .. ..     |    | . |  ..      |   .  .|. |     |  |     | .      ..|   
vmlcqfletnrekcaeyfprnahcclqfdklsvs.....yedstvnk.s..lvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar.s

DNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEPCIVDIVKSIRS-QRPRAVDSFCQYCSLYISLLYF
   .|    | ||.| ..|. .|...| .... | | .||  .|   |  .|... ||  ..  || |
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0051299 (Phosphotyrosine protein) phosphatases II 183-435 2.4e-36 121.1 In-house 23-287 (288) alignment 
Range on Protein: 183-435
Range on HMM: 23-287/288.0
AEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVE-------KDYVNISRVEI-PLGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDV
. ...|||.|.|...|..  .  ...| . |.. |....|..  |.         ||.| | ... .|.|   . | | ..| | ||. |.....  | .
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

IVGDE------PIEFFPKkaEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPH----GCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLkaP
. . .         ..|   .....||.........|   ||.  . .|| ..    |...|.....    ||  ..||      ..    ....|   .
ltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..s

ADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 .   .. . .| ||.| |.|| .... ....  .. . ..|| .|.||| .| ...||  .|  ||...|
gggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 183-432 4e-15 50.5 In-house 6-257 (267) alignment 
Range on Protein: 183-432
Range on HMM: 6-257/267.0
AEVKKEFEKLQSMKVDVEK-ECKTWKANSKYNQSEDFPALDSN---LLKVEKDYVNISRVEIPLGRNIY-IGQVPVKDTEETFWKAVFDKRIvSIDVI--
 |..||||... .  .  .  .   . | . |. .|    | .   | . |..|.| | ||    .| . . | |.| |   |.. . |... ...|.  
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkv.pvivllt

-VG-DEPIEFFPKKAEDYKNYGQMWINnRKVEYVSDDvfrFSIEVLPHGCSNSIICNVTVISnWKVDSVPVKQAIAIKEAFGLNSYLLKAPADDNAMINS
 |. |.   |.| |  . |.| .. .. . .|   .|   . | .|     |    |||.   .|   . ...   .|  ||. .      ..   ... 
kvftdnirlfwPPkmgqakkyqdltve.hslekeend...yqiitlelkfknesahnvtlyy.ykkwnintnnkpylkplfgilaknqlengnrPlvvac

QHGAGRAGYFLALAVAVHTIDTKVAEpCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLY
. | ||.| || .   .. . |      | | .. |||||.  ||.  .|  .. .|  
sdGvGrsGtflvidsqleraktegvs.difdflrkirsqriglvdtkeryiyihellae
subfamily_PTPRB_pd Subfamily PTPRB 183-438 1.2e-13 45.8 In-house 25-289 (293) alignment 
Range on Protein: 183-438
Range on HMM: 25-289/293.0
AEVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKR---IVS
.....|.|.|.... | .... . ..|.. |. ..  . | . .|.       ..||.| . ..    .. .|  | |. .| . ||. |..|.   || 
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

IDVIVGDEP---IEFFPKKAEDYkNYGQMWINNRKVEYVSDDVFR-FSIEVlphGCSNSIICNVTvISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPADD
.  .|        |..|.. |.  .||.. ..  . | ..| | | ..||    . ..  . .      |    || | .  ..    ..... |. .. 
ltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyh.ftsWpdhgvPektktlldfvrtvreaiektaskr

NAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKV
  ..    | ||.| |.||   ...|...     |. || ..|..|   | .  ||  .. ..| ...|| 
PivvhCsaGvGRtGtfialdrllqaieee.dyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_PTPN23_pd Subfamily PTPN23 183-435 6.8e-12 39.8 In-house 15-281 (288) alignment 
Range on Protein: 183-435
Range on HMM: 15-281/288.0
AEVKKEFEKLQSMKV--DVEKECKTWKANSKYNQSEDFPALDSNLLKVE---KDYVNISRVE--IPLGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDVI
....|.|..|.. .     .. .   | .|. |.|.|    |.|  |..    ||.| | |.   |   .. . | | . |   ||. |....   | ..
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVml

VGDEP------IEFFPKKAEDYKNYGQMWINNRKVEYVSDdVFRFSIEVLPHGCSNSI-ICNVtVISNWKVDSVPV--KQAIAIKEAFGLNSYLLKAPAD
.  |        ...|.. .. ...|.. .  ..|.  .  . .  ...  .. ..   .. .  . .|    ||   .. ... ..     .  . ...
lskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretet.hvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeavqrksk

DNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
   ...   | ||.| |  .  ||. ....   . |...|. .| ||   |    |.  .|   |  ..
tPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 184-436 5.4e-14 47.0 In-house 24-285 (319) alignment 
Range on Protein: 184-436
Range on HMM: 24-285/319.0
EVKKEFEKLQSMKVDVEKECkTWKANSKYNQSEDFPALDSNLL-------KVEKDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDVI
 ..|||..|.  . |  ... . . |.| |. ..  | |   .       . . ||.| | ..    |. .|  | |...| | ||. |.....  . ..
llekefkllkeavndtfdsa.skeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

VG-DEPIEFFPKKAEDYKN---YGQMWINNRKVEYVSDDVF-RFSIEVLPHGCSNSIICNVtVISNWKVDSVPVKQAiAIKEAFGLNSYLLKAPADDNAM
 .  |... . ||  ...|   ||.. ..  . |  .| .  ..... .        . .     .|  . || |   .. . ..      . . .   .
tklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhf.qyteWpdhdvPekat.slldllkrirksrektqsgPiv

INSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
.    |.|| | |..| ...  .    .   .  .|. .| ||.  |.   ||  .|  || ... 
vhCsaGvGRtGtfivldamlervkeegv.lDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPRK_pd Subfamily PTPRK 184-430 6.7e-13 43.1 In-house 23-273 (314) alignment 
Range on Protein: 184-430
Range on HMM: 23-273/314.0
EVKKEFEKLQSMkVDVEKEcktwKANSKYNQSEDFPALDSN---LLKVEKD----YVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSID--
 .|.|.| |     |. |.    . | . |.|.|  | |     |  .. |    |.| . ..     . .|  | |...| . ||. |.|..  ||   
gfkeeyeslfeg.wdaakk....denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivml

-VIVGDE---PIEFFPkkaEDYKNYGQMWINNRKVEYVSDDVFR-FSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNsyLLKAPADDN
  .|       ....|   || . ||.. ..  ..|  .. | | |..| | .| ..  . .     .|    |||..   .|    ..    ... . .
telvevgrvkClkyWP...edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvk..ksqeeeaGr

AMINSQHGAGRAGYFLALAVAVHTIDTKVAEpCIVDIVKSIRSQRPRAVDSFCQYCSLYISL
 ..    ||||.| |.|... .  |...     .  .||..||...  |.   ||  .|  .
ivvhCsaGaGrtGtfiaidivldmieregvv.dvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 184-434 1.7e-10 35.3 In-house 21-283 (290) alignment 
Range on Protein: 184-434
Range on HMM: 21-283/290.0
EVKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVE-----KD----YVNISRVE-IPLGRNIYIGQVPVKDTEETFWKAVFDKRIVSID
  ...|..|.| . . . . .. . |.. | ....   | | . .      ||    |.| . ..     .. .. | ||..|   ||| . ....  | 
gfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiiv

VIVG---DE---PIEFFPKKaeDYKNYGQMWINNRKVEYVSdDVFRFSIEVLPHGC-SNSIICNVTVISNWKVDSvPVKQAIAIKEAFGLNSYLLKAPAD
...    ..      ..|..  | |.||.. |.  . | .. .  .  .||  .    .. .     |.||. .   |..  .|  ..       . . .
mltniieegkvkCqqYWpds..dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrgn

DNAMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
   ..    . ||.. |.|.|...    |.     .....|| |.|.|  | .  ||  ..  .|  .
tsivvHCSdtvgrsavfcaaattinkcktegv.idvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
0046845 (Phosphotyrosine protein) phosphatases II 185-440 4.6e-37 123.3 In-house 2-280 (284) alignment 
Range on Protein: 185-440
Range on HMM: 2-280/284.0
VKKEFEKLQSMKVDV--EKECKTWKANSKYNQSEDFPALDSNLLKVE--------KDYVNISRVEIP------LGRNIYIGQVPVKDTEETFWKAVFDKR
...|||.|.|..|..  . ..  ...| . |.. |....|..  |.          ||.| | |. .        ... . | |...| | ||. |....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IVSIDVIVGDEP------IEFFPKKaEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPHG-CSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLL
.  | .. . .         ..| . .....||.........|.  ||. .. .|. ..| ...|.....  . .|  ..||   .. ..    ....| 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

KAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVA--EPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTK
. | .   .. . .| ||.|.|.|| .. . ....    .. . ..|| .|.||| .| .. ||. .|  ||...|.|.|.
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
DSPc_SM00195 185-435 1.8e-33 111.4 In-house 2-263 (263) alignment 
Range on Protein: 185-435
Range on HMM: 2-263/263.0
VKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVEK-------DYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV
.|.|||||.... . |.... .|.|.. |......  |..  |..|       ||.| . ....  .. ||  | | ..| | ||. |.....  | ...
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GDEP------IEFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVP--VKQAIAIKEAFGLNSYLLkapaDDN
 .|        ...|.........|.. .....|| ..|.. .  .|.  .|....  ...  . ||.  .||   |. ... .|.   .       .  
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgp

AMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 .. .. | ||.| |... .... ....   . | .|||..|.|||..|... ||  .|  .|..||
ivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 185-435 1.8e-33 111.4 In-house 2-263 (263) alignment 
Range on Protein: 185-435
Range on HMM: 2-263/263.0
VKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVEK-------DYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV
.|.|||||.... . |.... .|.|.. |......  |..  |..|       ||.| . ....  .. ||  | | ..| | ||. |.....  | ...
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GDEP------IEFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVP--VKQAIAIKEAFGLNSYLLkapaDDN
 .|        ...|.........|.. .....|| ..|.. .  .|.  .|....  ...  . ||.  .||   |. ... .|.   .       .  
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgp

AMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 .. .. | ||.| |... .... ....   . | .|||..|.|||..|... ||  .|  .|..||
ivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 185-437 2.5e-14 48.0 In-house 17-279 (281) alignment 
Range on Protein: 185-437
Range on HMM: 17-279/281.0
VKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV
 ..|.|||... ||   .  . ..| . |.  .  | |    ||       . ||.| . |.   | . ||  | || .. ..||. |.....  | .. 
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

G---DEPI---EFFPKKAEdYKNYGQMWINNRKVEYVSDDVFRfSIEVLPHGCSNSIICNVTViSNWKVDSVPVKQAIAIKeaFGLNSYLLKAPA-DDNA
     . .    ..| ...   .||.. ... . |  .  . |  ...  ... .  . ...   .|    || . .  ..  |  . . |. .  .   
reieagklkChrYWPddns.elkygdvtvkstaeeekatyier.kfkleresgetreveqlay.taWPdhGvPattkelle..frkevlkltekktkapl

MINSQHGAGRAGYFLALAVAVHTIDTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
.|    | ||.| ..||  .|...... .|  . ..|...| .|   | .  ||  .|  .|  ..|.
vihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Ptp69D_pd Subfamily Ptp69D 185-437 3.6e-12 41.0 In-house 24-289 (307) alignment 
Range on Protein: 185-437
Range on HMM: 24-289/307.0
VKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKVE-------KDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV
..||.|||.. ..| . .    | |   |..||  | |..  |..        ||.| | ..    .. .|  | ||  | . ||. . .. .  | .. 
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

--GDEPIEFFPKK--AEDYKNYGQMWINNRKVEYVSDDVFRfSIEVLPHG-CSNSIICNVTV----ISNWKvDSVPVKQAIAIKEAF-GLNSylLKAPAD
  .. . .  .|    || ..||.. ..  . |  || . | ...|   . .|. .  .  |      .|| ||   ..| .. .    ...  |.    
nlteknrkkcakYWpiedevqygdilvklvseekhsdyiiR.eldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvre..lyklnr

DNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
   ..  . |.||.| |.||.. .. . .   .  |...|| .||||.  |.|. ||  || .|| .... 
sPivvhCsaGvgrsgifvaldsllqqlkae.dkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRA_pd Subfamily PTPRA 185-433 1.8e-11 38.5 In-house 34-294 (330) alignment 
Range on Protein: 185-433
Range on HMM: 34-294/330.0
VKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLL-------KVEKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV
...||. | . ...   |  . . | . |.  .    | . .       . | ||.| | ..    .. .|  | | ..| | ||. .....  .| .. 
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

G------DEPIEFFPKkaEDYKNYGQMWINNRKVEYVSD-DVFRFSIEVLPHGCSNSIICNV--TVISNWKVDSVPVKQAIAIKEAFGLNSyLLKAPADd
       .    ..|.  |    ||.. .. .... . |  |  | .. ||... .     |       |    ||..    .|    ... | .  |. 
elkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk.lnqqsag.

NAMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYF
  ..    |.||.| |..|   .. . ..     . ..||..| |||. | .  ||  .|  || .
pivvhcsaGvGrtGtfivldavlervkaerk.vdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 185-442 2.3e-11 38.4 In-house 22-288 (318) alignment 
Range on Protein: 185-442
Range on HMM: 22-288/318.0
VKKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDS-------NLLKVEKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIdVIV
...|.|.|.  .  | .   . ..| . |.  .  | |.          ... ||.| . ..    .. ||  | |. .| | ||. |...    | |..
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi.vml

GDEpIEFFPKKAED------YKNYGQMWINNRKVEYVSDDVFRfSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQaIAIKEAFGLNSYLLKAPADDNAM
 .|  |   .| .        ..||.. .. ..   .|| | | ...|  .....| .     . .|   .|| .    . .  .  |.  . .  .  .
tqe.eergkakvhryWPskgsrsygklvvelkeevelsdyvlr.efkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaqqksgagpiv

INSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPA
.    | ||.| |.|. . .. |    |   . ..|| .|.||.  |    ||  .|  || ...   |.  
vhCsaGvGrtGvfiavdillerikae.alvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 185-424 2.7e-10 34.6 In-house 8-256 (283) alignment 
Range on Protein: 185-424
Range on HMM: 8-256/283.0
VKKEFEKLQSMKV-DVEKECKTWKANSKYNQSEDFPALDSNLLKVE---KDYVNISRVE----IPLGRNIYIGQVPVKDTEETFWKAVFDKRIVSID---
 |  .|.|. . | | . .... . | ..|. ..  . | . ....   .||.| . .        ...  | | |...|   ||| |||..|..|    
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

VIVGDEPI---EFFPKKAEdyKNYGQMWINNRKvEYVSDDvfrFSIEVLPHGCSNSIICNVTvISNWKVDS-VPVKQAIAIKEA--FGLNSYLLKAPADD
 .  |. |    ..||.    ..||.. .  || |. |.    |.|  |    ..|   ..  .. ..|.  . . .   |     | .   | .   . 
klqedlrikCsqyWPkrGs..edyGeftvtlrk.ettsns...fiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkg

NAMINSQHGAGRAGYFLALAVAVHTIDTKVAEpCIVDIVKSIRSQRPRAVDSFCQYC
  ..    | ||.. |.|....|. . |.     .  .|| .| ||. || .  || 
PivvhCstgiGrtavfiaasasvkdaltesvv.dvfavvkimreqrmmavqtldqyk
0045098 (Phosphotyrosine protein) phosphatases II 186-436 9e-20 66.6 In-house 10-274 (278) alignment 
Range on Protein: 186-436
Range on HMM: 10-274/278.0
KKEFEKLQSMKVDVEKECKTWKANSKYNQSEDFPALDSNLLKvekDYVNISRVEIPlGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPI----
. ||| | ..    | ..  .  | . |   |....|..  |   ||.| | .... ...  . | | ..| . ||. ... .| .|  . . ..     
llefefllllgipseitpalylgnldknRykdilpydhsrVk...dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

--EFFPKkaEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLP---HGCSNSIICNVTVISNWKVDSVPVKQ--AIAIKEAFGLNSYLL-----------KA
  ...|   .....||...... ..|...| . |. . .     .    |   ..  . .|   .||     .  ..    ....|              
caqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

PADDNAMINSQHGAGRAGYFLALAVAVHTIdtKvAEPCIVDIVKSIRSQRPR-AVDSFCQYCSLYISLLYFIKK
. .    .  ..| ||.| . |.    . .  .    .. ..|| .|||||  || .. ||  ||  ||.....
dsggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRG_pd Subfamily PTPRG 186-445 1.2e-11 38.5 In-house 22-298 (563) alignment 
Range on Protein: 186-445
Range on HMM: 22-298/563.0
KKEFEKLQSMKVDV--EKECKTWKANSKYNQSEDFPALDSNLLKV------E--KDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDV
..|||.|||  ..   . |    . | . |   .  | |.   |.      .  .||.| . ..     . .|. | |.||| . ||. .....   | .
seefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivm

IVG------DEPIEFFPKkaEDYKNYGQMWINNRKVEYVS-DDVFRFSIEVLPHGCSNSiICNVTVISNWKVDSVPVKqAIAIKEAFGLNSYLLKAPADD
|         .   ..||  .. ..||.. ..  . | ..   | ...|. |     ..   .. .. ...  . | . .   .... |.    .. |  
itnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdh.gvPehslpvLifvkkssaank

----NAMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGD
      ..  ..|.||.| ...|   .. | .. |   . ...| ||.||.  | .  ||  |.  ||  |. | |.  . .
aeaGPivvHcsaGvgrtGtyivldtllkqiqqena.vnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 186-434 6.6e-11 36.3 In-house 23-279 (439) alignment 
Range on Protein: 186-434
Range on HMM: 23-279/439.0
KKEFEKLQSMKVDVekECKTWKANSKYNQS----EDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSID
|..|||..|.. |   .|..  |  .|.|.    .|  |.|     .          |.|   ..     ..||  |.| |.| ..||. |..|. | | 
keifekinstspdy..aciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtiv

VIV-GDEPIEFFPKKAEDYknYGQMWIN-NRKVEYVSDDVFRFSIEVL-PHGCSNSIICNVTVIsNWKVDSVPVkQAIAIKEA-FGLNSYLLKAPAdDNA
..    |   ..| .|| .  ||.. .  .|..|     .  | .     ..  .  . ..  |  |    ||  ||  . .    .||   |       
mltnlvesykywpsdaevc..ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyi.awpdknvpa.qashvldflrainsandkeey.gpv

MINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
..    | ||.|  .|| .|.  . ..  .  |  ||| .| || . |...|||  .| ..|  |
vvhcsagvGrtGtiialdialeqlkle.nkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 187-431 7.6e-06 19.6 In-house 24-233 (392) alignment 
Range on Protein: 187-431
Range on HMM: 24-233/392.0
KEFEKLQSMKVDVEKECKTwKANSKYNQSEDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIVG-
.||  | . ..  .. ... . | | |. ..   .||. .|.       ..||.| | ..     . ||  | |   . . ||. ||.... .| ..   
eefhdlpgpdiypqtvaqk.einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl

---DepieffpkkaedyknygqmwinnrkveyvsddvfrfsievlpHGCSNSIiCNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLlkAPADDNAMINSQ
   |                                          .| ..   .    ...|  . || . .  .|    ...           .|   
kegd..........................................kgddart.vaqfhftewPdkdvpkhtssllkfikevkadf..Gqythpliihcs

HGAGRAGYFLALA-VAVHTIDTKVAEpcIVDIVKSIRSQRPRAVDSFCQYCSLYISLL
 | ||.|  ...  |  |.  |.. .  ....|  || .||  |..  ||. .| ..|
agvgrtgvvisidsvvahakktrmvd..vfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 190-432 9.1e-14 46.3 In-house 29-281 (305) alignment 
Range on Protein: 190-432
Range on HMM: 29-281/305.0
EKLQ----SMKVDVEKECKTWKANSK-YNQSEDFPALDSNLLKVEKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV----GDE
..|.    |..|. ... |. .....   . .|   |  .  . ..||.| | |.   ... ||  | |.|.| . ||. ... ....|  ..    |..
kslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggk

--PIEFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKeafgLNSYLLKAPADD---NAMINSQ
     ..|..  . |..|.. .. .  . .|| . |       .. ..|       . .|  . || . .  ..    |   . |.   |     ..   
dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls....likrvqkdqkkdkgvpllVhCs

HGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLY
 | ||.| |.|. .|.  . .   .  . ...| .||.|. .| .  || .|.  |  
agvgRtGvfiavdialerlkkE.evvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 197-312 3.6e-06 20.9 In-house 37-159 (301) alignment 
Range on Protein: 197-312
Range on HMM: 37-159/301.0
VDVEKECKTWKANSKYNQSEDFPALDSNLLKVEKDYVNISRVEIPLGR-NIYIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPI------EFFPKKAE
 . .|... .| .. |.. .   .  .|| . ...|.| | ..    . .  . | |.| |   ||. ..... ||| .. . .        ...|.  .
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnsea

DYKNYGQMWINNRKVEYVSDDVF
. ...|.. .   .   . | | 
eseefgpftvtlvneqvyPdfvi
0040439 (Phosphotyrosine protein) phosphatases II 201-436 8.3e-34 112.7 In-house 3-248 (249) alignment 
Range on Protein: 201-436
Range on HMM: 3-248/249.0
KECKTWKANSKYNQSEDFPALDSNLLKVEK-------DYVNISRVEIP-LGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPI------EFFPK
...  ...| ..|.. |....|..  |..        ||.| | .. .  .|.. . | | ..| | ||. ... .| .|  .  ...       ...| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

kaEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLAL
  .....||........||. .||. .. .|. ......|. ...  . .|  ..||   .....    ....| ..| .   .. . .| ||.|.|.|.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

AVAVHTIDtKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
  ... .. |  . .. ..|| .||||| || .. ||. ||  ||....|
ylmleqle.kelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 202-435 1.4e-31 105.2 In-house 2-244 (245) alignment 
Range on Protein: 202-435
Range on HMM: 2-244/245.0
ECKTWKANSKYNQSEDFPALDSNLLKVE-------KDYVNISRVEIPL-GRNIYIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPI------EFFPKk
..  ...| ..|...|....|... |.         ||.| | |  .   ......| | ..| | ||. ... .| .|  .  .|.       ...|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

aEDYKNYGQMWINNRKVEYvSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKaPADDNAMINSQHGAGRAGYFLALA
 .....||.........|.  ||. .. .|| ..|.. |  ...    .|  ..||   .. ..    ....| . ...   .. . .| ||.|.|.|. 
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaay

VAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 ... ...   . .. ..|| .||||| || .. ||  ||  ||...|
lmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 203-433 1.8e-17 59.2 In-house 4-241 (243) alignment 
Range on Protein: 203-433
Range on HMM: 4-241/243.0
CKTWKANSKYNQSEDFPALDSNLLKVE-KDYVNISRVEIPlgRNIYIGQVPVKDTEET----FWKAVFDKrivSIDVIV--------GDEP-IEFFPkka
.  ...| . |.  |....| .  |.|  ||.| . ....  ......|.| ..| |     ||. ...     |.|||        | |   ...|   
iallpenlsknrysdilpydhsrvklegsdyinanliyvt..prliatqgPlpetveddlasfwrmlwel...gitvivmltelvElgrekcaqywp...

EDYkNYGQMWINNRKVEYVSDdVFRFSIEVLPHGCSNSIICNVTVISNWKVD-SVPVKQAIAIKEAFGLNSYLLK------APADDNAMINSQHGAGRAG
... .||...... ..|. .| .  . ... ......    .. .      | .||   .. ..    ..... .      .. .    .   .| ||.|
gev.tygdftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

YFLALAVAVHTIdtkvaEPCIVDIVKSIRSQRPR-AVDSFCQYCSLYISLLYF
...|. .  . .     .  . ..|| .|.|||  || .. ||  ||  ||..
tliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN1_pd Subfamily PTPN1 203-395 2e-06 21.7 In-house 29-230 (290) alignment 
Range on Protein: 203-395
Range on HMM: 29-230/290.0
CKTWKANSKYNQSEDFPALDSNLLKVEKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKR---IVSIDVIVGDEPI---EFFPKKAEdyknYG
 .. ..  .|   . .     .| . ..||.| | ||..  .  ||  | |. .| . ||. |....   .| .. .|  | |   ...|.. |      
lpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee....ek

QMWIN--NRKVEYVSDDVFR-FSIEVLPHGC---SNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVA
.. ..  . ||...| .. . . ...|        ..          |   .||   |  .|  | . .    ..    |.|    | ||.| |  .   
ellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtc

VHTIDT
.  |. 
lvliek
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 206-439 7.8e-09 29.9 In-house 32-276 (285) alignment 
Range on Protein: 206-439
Range on HMM: 32-276/285.0
WKANSKYNQSEDFPALDSN---LLKVEKDYVNISRVEIPL-GRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV-----G-DEPIEFFPKKAEDYKNY
..||   |.  |  ...     | . ..||.  | . .|   .. ||  | |. .|   ||. .....|  . ...     | ..   ..|.|  .  ..
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

GQMWI--NNRKVEYVSDDVFRfSIEV--LPHGCSNSIICNVtVISNWKVDSVPVKQAIAIKEAFglnSYLLK-APADDNAMINSQHGAGRAGYFLALAVA
|.  |   . | | ..  ..  .. |      .|. .  |  |   |  | .  ..|  . | .    .. |  | .    .    | ||.  |. .  |
gkyeitlteckeeaiagtiln.altvintedasseplymnh.vqvpwwpdqlapedarpmiely...kwvkkvnpkekpicvhcsagvgrtatfvgidya

VHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLL-YFIKKKVT
   |  .  .  ..|||. .|. | .||.|. |.  ||. |. ||| . | 
tirimen.pniemldivremramrfqavqshmqflflyvvlmeyfigegvv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 207-434 6.9e-10 33.4 In-house 45-278 (287) alignment 
Range on Protein: 207-434
Range on HMM: 45-278/287.0
KANSKYNQSEDFPALDSN---LLKVEKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIVGDE------PIEFFPKKAEdyKNYGQ
. | . |.....   | .   | . ..||.| . ..    .. .|  . |. .|   ||| . |...  | ... ..        ...|...     .|.
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe

MWINNRKVEyVSDDVFRFSIEVLPHG-CSNSIICNVTVISNWKVDS-VPVKQAIAIKeaFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTID
  |.  . | |....    .||  ..  ..    .   | ||.    |. .|.| .   .       . ...   ..    . ||.. |.| |....  .
yniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillv..ieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkck

TKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
|  .   .....|| | |.| .|    ||  ..  .| ..
teGv.iDvfqvlksqriqkpgsvqtveqykfindivleyl
Y_phosphatase Protein-tyrosine phosphatase 209-430 1.4e-32 108.4 Pfam-A 1-233 (235) alignment 
Range on Protein: 209-430
Range on HMM: 1-233/235.0
NSKYNQSEDFPALDSNLLKV-----EKDYVNISRVE-IPLGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPI------EFFPKKAEDYKNYGQ
|.| |...|... |..  |.     ..||.| . |.  .  ... . | |.|.| | ||. |..... .| ... .|        ...|.. |....||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MWINNRKVEYVSDDVFRFSIEVLPHGCSNS---IIcNVTVISNWKVDSVP--VKQAIAIKEAFGLNSyllkAPADDNAMINSQHGAGRAGYFLALAVAVH
. ..... |   .. . ..   | . ...|   .. ..  . ||.  .||  .|. . . ...  ..    .. . . .. . .|.||.| |.|| ....
ikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldille

TIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISL
 ....   . ...|||..|.||| .|.|. ||. ||  .
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 209-430 1.4e-32 108.4 In-house 1-233 (235) alignment 
Range on Protein: 209-430
Range on HMM: 1-233/235.0
NSKYNQSEDFPALDSNLLKV-----EKDYVNISRVE-IPLGRNIYIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPI------EFFPKKAEDYKNYGQ
|.| |...|... |..  |.     ..||.| . |.  .  ... . | |.|.| | ||. |..... .| ... .|        ...|.. |....||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MWINNRKVEYVSDDVFRFSIEVLPHGCSNS---IIcNVTVISNWKVDSVP--VKQAIAIKEAFGLNSyllkAPADDNAMINSQHGAGRAGYFLALAVAVH
. ..... |   .. . ..   | . ...|   .. ..  . ||.  .||  .|. . . ...  ..    .. . . .. . .|.||.| |.|| ....
ikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldille

TIDTKVAePCIVDIVKSIRSQRPRAVDSFCQYCSLYISL
 ....   . ...|||..|.||| .|.|. ||. ||  .
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 209-432 1.3e-08 29.1 In-house 44-275 (315) alignment 
Range on Protein: 209-432
Range on HMM: 44-275/315.0
NSKYNQSEDFPALDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV----GDE--PIEFFPKKAEDYKNY
| | |. ..   |||. .|.       ..||.| | ..     . ||  | | | . . ||. |..... .| ..     ||      ..|..  |  ..
nfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvef

GQMWINNRKVEYVSDDVFRFSieVLPHGCSNSIICNVtVISNWKVDSVPVKQAIAIKEAFGLNSYllKAPADDNAMINSQHGAGRAGYFLALAVAVHTID
|.. ..  ..|  .| | |    |. .. .   . .     .|    |. ...  .|    . .   . . . . ..    |.||.| ....   |  | 
Gsikvellsleadtdgvarkl..vtrkseesrtvtqf.qftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidevvaqik

TKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLY
 .     . ..|| .|..||  | .  .|  .| ..| 
rt.rsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_egg_pd Subfamily egg 220-445 7.6e-12 39.5 In-house 68-281 (307) alignment 
Range on Protein: 220-445
Range on HMM: 68-281/307.0
AldsnllkvekDYVNISRVE-IPLGRNIYIGQVPVKDTEETFWKAVFDKR---IVSIDVIVGDEPIEF-FPKKAEDYKNY--GQMWINNRKVEYVSDDVF
           |..   ||.  ||  .  . | |.|.| . ||. || ..   || ..  .  |  |. .||  .|   .  | . |.| ||.  .| .|
d..........dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplf

RFSIEVLpHGCSnsiiCNVTVISNWKVDsvpVKQAIAIKEAFGLnsYLLKAPADDNAMINSQHGAGRAGYFLALAVAV-HTIDTKVAEPCIVDIVKSIRS
| .   |  |       .   .  |. |   |...  .   . .    .   .   ...... |  .|. ..|. .|. . .   .    .   |. .| 
rvtklkl.vGgd....deerflehwqgd...vnnssdvysplrv..lrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrl

QRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGD
.|. .|.|  .|  .|  .|.|..  .    | |
rrrlsvesvllylfvyrlvlfffrdvigsakeld
subfamily_PTPN12_pd Subfamily PTPN12 221-440 6.6e-12 39.9 In-house 52-283 (290) alignment 
Range on Protein: 221-440
Range on HMM: 52-283/290.0
LDSNLLKV-------EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVsIDVIVGDE-------PIEFFPKKAEDYKNYGQMWINNRKVE
 | . ...       ..||.| . .. . |.  ||  | |. .| . ||. ...|..  | |..  |          ..|.. |.  ..|.. ... . .
ydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknve.ivvmaCrevelgkkkCerYWpeegeeelefgefevtleeek

YVSDDVFRFSIEVLPHGCSNSIicNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLkaPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEPC--IV
 |.|| .  ...|  .. |...  .     .|    || ..   ..    ....      |   ..    | ||.|  .|.  . . . ..  ...  . 
avdddflirtLkveaqkesrkv..yqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvf

DIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTK
|.| ..| ||. .| .  ||  .| ... ...|... 
dlvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 228-431 1.4e-08 29.1 In-house 75-276 (315) alignment 
Range on Protein: 228-431
Range on HMM: 75-276/315.0
VEKDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIdvIVGDEPIEFFPKKAEDYKNYGQMWINNRKVEYVSDDVF-RFSIEVLpHGCSN
 . |||| . ..    .. ||. | |   . . ||. ||.. |  |  ..  . .|   .||| |    ..   .  |  .|..|. ....  |    ..
phsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigki..vmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl.svvfg

SIICNVTV--ISNWKvDSVPVKQAIAIKEAFGLNSYLLKAPAdDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEpCIVDIVKSIRSQRPRAVDSFCQY
. | .|    .. |  |.   | .|.. . .       .. .    ..  . | ||.| |..|   .. .... |   . .... .|..| ..|..  ||
dnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenai.dvynfitgvrqnrikmvqvaeqy

CSLYISLL
  .|  ||
qfiydall
subfamily_CG7180_pd Subfamily CG7180 229-434 9.7e-14 45.7 In-house 69-290 (296) alignment 
Range on Protein: 229-434
Range on HMM: 69-290/296.0
EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIVG--DEP---IEFFPKKAedYKNYGQMWINNRKVEYV---SDDVFRFSIEVL
..||.| . |.  |  . ||  . |.|.| . ||. |.|. | .. |.    |      ...|.|.   ..||.. ..  ...         |.   ...
ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkiv

PHGC------SNSIICNVTVISNWKV-DSVPVKQAIAIKEAFGLNSYLLKA---PADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSI
  .        .  |. .  .  |.. |.||.  .  |.     ...  |.   |     .. |. ||.|.| .||. ...  .. .  |  . . || .
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelveke.eevdvFeavktl

RSQRPRAVDSFCQYCSLYISLLYFI
| .||. |..  .|  .|  || ..
rrsRpqLvenveeYkyiYdvlleav
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 229-431 2.8e-13 44.7 In-house 36-239 (250) alignment 
Range on Protein: 229-431
Range on HMM: 36-239/250.0
EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV-----GDEPIEFFPkkAEDYKNYGQMWINNRKVEYVSDDVFRfSIEVLPHG
| ||.| | ..   .|. .|  | |...| | ||. |... . .| ..      . .  ...|  .|  ..||.. ..  . |  .| . |  . .  . 
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vekaekyGdvtvsllskeefadytkr.klklskak

CSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKApADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVaEPCIVDIVKSIRSQRPRAVDSFCQ
 ... |       .|   .|| .   ...    ...   .|  .   ...   | ||.| |.|.   .. . ..     . ...| .| .||.||.|  |
kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiaidavlerlkkek.vvdvfkvikvlrkdrphavesleq

YCSLYISLL
| ..|  .|
yvfvyeiil
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 229-432 7.7e-13 43.2 In-house 75-286 (325) alignment 
Range on Protein: 229-432
Range on HMM: 75-286/325.0
EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSI---DVIV--GDEPIEFFPKKAEDYKNYGQMWINNRKVEYVSDDVFR-FSIEVLPH
. ||.| | ..   ......  |.|  .| . .|. |.| |   .   ...    |.   ..||.  . |..| . .. | .| .|| | | . .    .
ssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk

GCSNSIicNVTVISNWK---VDSVPVKQaIAIKEAFGLNSYLLKA--PADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRA
| . |.  .   .  |.   |.  |    |.| .     |  ..|   |    ..    | ||.| |..|  |.  . .. ..  | . || .| .||  
Getrsv..kqfqlqswddmGvqkrpatl.isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviee.srvdifgfvkklrkdrpsm

VDSFCQYCSLYISLLY
|..  ||  .| .|  
vetvdqyiliyealve
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 229-433 2.4e-12 41.8 In-house 81-293 (319) alignment 
Range on Protein: 229-433
Range on HMM: 81-293/319.0
E-------KDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDVIVGDEPIEFFPKKAEdyKNYGQMWINNRKVEYVSDDVFRfSIEVLP
|        ||.| | |.    .. ||  | | ..| . ||. ... .. .| ..  |   ...|.|..  ...... ..   ||  .. | | .||.  
erliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkdkcsqywplkiv..ikeerfkvkvdsveetaeyvvr.dielse

HGCSNSI--ICNVtVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVD
.|  . |  | .   .  |    ||   .  ..    ..    |     | ..    |.||.| ...| | .. .. .     . ..|. .| ||.. |.
dgkekdirkitqf.hflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee.kqvdvynfvrdlrqqrntlvq

SFCQYCSLYISLLY---F
.. ||  .|..||    |
dlvqykfiysalleehlf
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 229-433 2e-07 25.5 In-house 78-283 (297) alignment 
Range on Protein: 229-433
Range on HMM: 78-283/297.0
EKDYVNISRVEIPLGRNIyIGQVPVKDTEETFWKAVFDKRIVSIDVIVGDEPIE-----FFPKKAedYKNYGQMWINNRKVEYVSDDVFRfSIEVLPHGC
. |||| | |.    | |   | | |.| . ||. |.|...  | ..  |.  .     ....|.   ...|.. .    |.  .  . | ..||     
dsDyvnasfvkgnkhrli.ttqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg..vttfGdvsvvllsvsereGfikr.elevtkgka

SNSIICNVTVISNWKVDSVPVKQ-AIAIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQ
 .  . .     .| ...|. |. | .. .         .  |.   ..    | ||.| .|..   |  .  .  |  | ..|| .| .||  |    |
karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakre.kevdifglvkklrqerpylvqtkeq

YCSLYISLLYF
|  .|  .| .
ykfvyvavlea
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 229-431 6.4e-07 22.8 In-house 70-273 (515) alignment 
Range on Protein: 229-431
Range on HMM: 70-273/515.0
EKDYVNISRVEIPLGRNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIV----GDEP--IEFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRfSIEVLPH
..||.| | ..     . ||  | | | . . ||. |.....  | ..     ||     ...|.|  |  ..|.. ..   .|  .. . |  ..||  
hsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikr.kltvlkg

GCsNSIICNvTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPadDNAMINSQHGAGRAGYFLALAVAVHTIDTK-VAEpcIVDIVKSIRSQRPRAVDSF
      .       .|    || .    .|    . .   .       .|    |.||.| ....   |  . |  . .  . ..|. || .||  |   
dd.srtvtq.fhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahakttrmvd..vfnfvtnirqkrpylvqtq

CQYCSLYISLL
 ||  .|  .|
eqyafiygavl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 230-434 1.1e-12 43.1 In-house 53-258 (284) alignment 
Range on Protein: 230-434
Range on HMM: 53-258/284.0
KDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDVIVGDEPIEFFPKKAEdyKNYGQMWINNRKVEYVSDDVFRfSIEVLPHGCSNS--
 ||.| | ..    .. ||  | | ..| . ||. ... .. .| ..  |   ...|.|..  ...... ..   ||  .. | | .||.  .|  .   
sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdkcsqywplkiv..ikeerfkvkvdsveeseeyvvr.dielsedgkekdir

IICNVtVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKvAEPCIVDIVKSIRSQRPRAVDSFCQYCSL
 | .   .  |    ||   .  ..    ..    |     | ..    |.||.| ...| | .. .. .     . ..|. .| ||.. |....||  .
kirqf.hflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkee.kqvdvynfvrdlrqqrntlvqdlvqykfi

YISLLY---FI
|..||    | 
ysalleehlfg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 230-436 1.4e-07 25.9 In-house 57-270 (274) alignment 
Range on Protein: 230-436
Range on HMM: 57-270/274.0
KDYVNISRVEIPLG-RNIYI-GQVPVKDTEETFWKAVFDKRIVSID---VIVGDEP---IEFFPKKAED--YKNYGQMWINNRKVEYVSDdvFRFSIEVL
 .|.|   .  . .  ..|.  | |.  | . ||. .. ...  |     .   .     ..||.. .    ..||.. |...|.    |  ..    ||
ssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekivernd..ysvrklvl

PHGCSnSIICNVTVISNWKVDSVPVKQAIAIKEAFGLNSYLLKAPAD-DNAMINSQHGAGRAGYFLALAVAVHTIDTKVAePCIVDIVKSIRSQRPRAVD
 .  . .  .     ..|    .| .    ..     ..   .. |    ...    | ||.| |.|  .||. .. .     .. ||  .| .|   |.
kyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeiv.vdvlkivcnlrldrGGmvq

SFCQYCSLYISLLYFIKK
.  ||  ..  |  . |.
tseqyelihralclylkr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 230-431 5.2e-07 24.1 In-house 35-237 (239) alignment 
Range on Protein: 230-431
Range on HMM: 35-237/239.0
KDYVNISRVEIPLG-RNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIVGDepIEFFPKKAEDYK-----NYGQMWINNRKVEYVSDDVFRFSIEVlPHG
 ||.| | .    |  . ||  |  |. .   ||. ....| . | .. |   || . ||. .|      .| .. .  || | ..| . |  .     |
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgl..ieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvms.qvg

CSNSIICNVTVISNWKVDSVPVKqAIAIkeaFGLNSYLLK--APADDNAMINSQHGAGRAGYFLALAVAVHTIdTKVAEPCIVDIVKSIRSQRPRAVDSF
 ..        .. |    ||   | |.   .||   . |   |     .|    | ||.| || .   ..    |     |.. ||.|| .||. |.. 
qteeryvyqyhftvwpdkgvpqy.atav...lglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa.kkqktvdifnyvkairedrphmvqts

CQYCSLYISLL
 ||  .....|
eqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 230-430 5.6e-07 24.0 In-house 36-237 (239) alignment 
Range on Protein: 230-430
Range on HMM: 36-237/239.0
KDYVNISRVEIPLG-RNIYI-GQVPVKDTEETFWKAVFDKRIVSIDVIVGDepIEFFPKKAEDYK-----NYGQMWINNRKVEYVSDDVFRFSIEVlPHG
 ||.| | .    |  . ||  |  |. .   ||. ....| . | .. |   || . ||. .|      .| .. .  || | ..| . |  .     |
sdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgl..ieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvms.qvg

CSNSIICNVTVISNWKVDSVPVKqAIAIkeaFGLNSYLLK--APADDNAMINSQHGAGRAGYFLALAVAVHTIdTKVAEPCIVDIVKSIRSQRPRAVDSF
 ..        .. |    ||   | |.   .||   . |   |     .|    | ||.| || .   ..    |     |.. ||.|| .||. |.. 
qteeryvyqyhftvwpdkgvpqy.atav...lglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa.kkqktvdifnyvkairedrphmvqts

CQYCSLYISL
 ||  .....
eqyvfihlav
0051429 (Phosphotyrosine protein) phosphatases II 231-441 4e-08 28.7 In-house 5-232 (272) alignment 
Range on Protein: 231-441
Range on HMM: 5-232/272.0
DYVNISRVEIPlGR----N-IYIGQVPVKDTEETFWKAvFDKRIVSIDVIVGDEPIEFFP----------------KKAEDYKNYGQMWINNRKVEYVSD
.|.| . |  . ||    . .| .. | . |.. ||.   . .| .|  . ..| .....                  ..   .||.... . ..|. .|
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

DVFRFSIEVLPHGCSNSIICNVTVISNWKVDSVPVKQAIAIKEAFGLnsyllkapaDDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEP-------CI
 . |. . .| .. ...    . .  .|  ..|| .. ... |..           . . ..   .| .| | . ||   .. ..  .          ..
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

VDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKP
 ..|. .|.||| || .  ||  ||  || ....  . .
eeaveelraqrpgavqteeqylflyeallellrsllsvr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 232-437 4.6e-07 24.1 In-house 50-267 (270) alignment 
Range on Protein: 232-437
Range on HMM: 50-267/270.0
YVNISRVEI-PLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDVIVG------DEPIEFFPKKAEDYKNYGQMWINNRKVEYVSDDVFRF-SIEVLPHG
|.|   |.     .. ||  . |.. | . ||. .....  .| .. |      ..   ..|.....  .. .. |. .... . .. ...  ...  .|
YinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekg

CSNSIIcnVTVISNWKVDSVPVKQAIA--IKEAFGLNSYL--LKAPADD--NAMINSQHGAGRAGYFLALAVAVHTIDTKVAEPCiVDIVKSIRSQRPRA
 .. ..       .|  ..|| ..  .   ..   .   .   .   |.    ..    | ||.| ..||  ||.......   . . |.. .| .|.  
eerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdv.laiieelRkdRmal

VDSFCQYCSLYISLLYFIKKK
|.   ||  || ... .....
vqhpeqyeflykavveyaerr
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 250-459 1.8e-29 96.5 In-house 121-328 (346) alignment 
Range on Protein: 250-459
Range on HMM: 121-328/346.0
QVPVKD---TEETFWKAVFDKRIVSIDVIVGDEPI-----EFFPKKAEDYKNYGQMWINNRKVEyVSDDVFRFSIEVLPHGCSNSIICNVTVISNWKVDS
|.|  .     | ||  .....|  . ..| |. .      .|  .   |.  |.|.||||. . || |   ..||||| | |.|.||.|   . ||   
qlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrrad.vsgdpkeytievlpegnsdsvicqvhhhapwkhlq

VPVKQAIAIKEAFGLNSYllKAPADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVaEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKvtkp
 | |    ||    . |   |   .    . |  |.|||  |.    |.. ..  . || |..|.|.|. ||| .|.|| ||.|.|  .. .| .|    
qppktlpiikmihqflse..kqvqnagvcvvslfgcgracsfigalyainqlnngi.epniceimknikqqrpggvesfaqyasiyaivfdyiark....

aEGDkKSTPTNKYLHKKS
  |  |..| ||....  
.rgg.kkapvnkdinrfi
PTPc_DSPc_SM00012 335-431 4.2e-15 51.2 In-house 8-104 (105) alignment 
Range on Protein: 335-431
Range on HMM: 8-104/105.0
SNWKVDSVPVKQaIAIKEAFGLNSYLLK-APADDNAMINSQHGAGRAGYFLALAVAVHTIDTKVAEPCIVDIVKSIRSQRPRAVDSFCQYCSLYISLL
..|.  .|| ..  .| |..       . .    . .. ...|.||.|.| ||..... ....  |..| .|||..|.|||..|... ||. ||  ||
tgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall