Gene Y62F5A.10 in Caenorhabditis elegans

Synonym: CELE_Y62F5A.10, Y62F5A.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP225_AA protein Get Run
CeleP225_AA_132-405 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 122-410 7.5e-48 158.9 In-house 6-295 (297) alignment 
Range on Protein: 122-410
Range on HMM: 6-295/297.0
TPALSEAPVKWKAEDVAVAYIGKLDASQTRPEYIDVCVATKaNiENCTVWKKNLAKNQTDVYPILDATLVKDPAKPD-----SYVNMSSVIVPHC-SYPI
 ..|.  |......|... .. ... .. . |. ...  .  .   .. ...|  ||.   ....| . ||   ...     .|.|.| | .... .  .
dallesipiplsvldlllllekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

LMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE---KYDFFPKTTGsflYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSnsVMMNVYVHTGWEPFG
.. | |  .  | |||  ....| .   |   ..     ....| ..|   .||...|...|||. ..   ..|.|| .|| |   ..... .|||  .|
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnnges..rtvthfqytgwpdhg

VPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV
||   .   . .  |............ || ...|.||.| ||..  ....|. . .. . |.|| .|.|||.||..  ||  || .||...|.| |.
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkltl
0050432 (Phosphotyrosine protein) phosphatases II 123-410 3.1e-50 166.6 In-house 17-305 (308) alignment 
Range on Protein: 123-410
Range on HMM: 17-305/308.0
PALSEAPVKWKAEDVAVAYIGKLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDpAKPDSYVNMSSVIVP--HCSYPILMGQI
. ..    |.  .|.. .. ..|| .. . |. ...  .  .  ... ...|  ||.   ....| . ||   ....|.| | | ..  ...  ... | 
tsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqg

PKRGLEEEFWRAAYNEQVVMMYVLVGSEDEK----YDFFPKTTG-SFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPI
|. .  | |||  ....| .  .|   .. .    . ..| ..| ..|.|| ..|.....|. ...  ..|.|. ..| ..| ..... .|.|. .||| 
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

RyantTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV
     .....| ...|..|..... .| ...|.||.| ||.|  ....|. . .. . |.|| .|.|||..|..  ||  || .||.|.|.|.| 
s....peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 126-419 2.4e-124 408.7 In-house 4-300 (302) alignment 
Range on Protein: 126-419
Range on HMM: 4-300/302.0
SEAPVKWKAEDVAVAYIGKLDASQTRPEYiDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGL
.|.. ||..|..|.... .||......|. . . ..|...|.|...||||.|||.. .||||..||| .|.||||||.|.| ||.....|...|.||.. 
eeekekWveeeeakklvksldtaevkkef.kkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvds

E---EEFWRAAYNEQVVMMYVLVGSEDEKY---DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYAN
|   |||||....|..|....|||.|. |.   ..|||..|....||.||||.|||||..||..||.|||||.|.||||..||||.| |..  ||..||.
edsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae

TTRSVVDVmnFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQKVE
.......|  |.|.....|....|||||.||||.|.|| .|...|....||.| ||||.||||||.||.|.|||.|||..||.|||||.| ||. ..|.|
liktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkkee
0043336 (Phosphotyrosine protein) phosphatases II 130-405 1.6e-45 151.1 In-house 2-278 (278) alignment 
Range on Protein: 130-405
Range on HMM: 2-278/278.0
VKWKAEDVAVAYIGKLDASQTRPEYIDVCVATKaNIENCTVWKKNLAKNQTDVYPILDATLVKDPAKP----DSYVNMSSVIVPHCSYPILMGQIPKRGL
...|    |...... . . .. |. ...  .. .  ... ...|  ||..  ....| ..||    .    ..|.| | | .....  ... | |  . 
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

EEEFWRAAYNEQVVMMYVLVGSEDEK----YDFFPkttGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTT
.| |||  ....| .  .|.. .. .    . ..|   |..|.||...|...|.|. ..   ..|.|| ..| ..| . ..| ..||  .|||   .   
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

RSVVDVMNFVKssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
. . .|.....  . ....|| ...|.||.| ||.|  ....|... .. . |.|| .|.|||.||..  ||  || .||.|.|
dflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 132-422 8.2e-51 168.5 In-house 2-294 (317) alignment 
Range on Protein: 132-422
Range on HMM: 2-294/317.0
WKAEDVAVAYIGKLDASQTRPEYIDVCVATKAnIENCTVWKKNLAKNQTDVYPILDATLVK----DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEE
.. .. |. .. |.|. . . |..|..  ..    ... ...|  ||.   ....|.. ||    ..  ...|.|.| | .|...  ... | |. .  |
vldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

EFWRAAYNEQVVMMYVLVGSEDEK----YDFFPKttGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIryanTTRS
 |||  ....| .   |. .|. .    . ..|   |..|.||...|.....|. ...   .|.|| ..| |.|...... .|||  .|||     ....
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp....spdl

VVDVMNFVKSS--NGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQKVEDL
..| ...|...  ......|| ...|.||.|.||..  ....|. . .. . |.|| .|.|||.||..  ||  || .||.|.|.|.| ..  ..|.. |
lldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkll

K
|
k
0036941 (Phosphotyrosine protein) phosphatases II 136-418 2.2e-53 176.9 In-house 1-291 (297) alignment 
Range on Protein: 136-418
Range on HMM: 1-291/297.0
DVAVAYIGKLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYN
|... ....|. .. . |. ...   .    ... ...|| ||.   ....| | || .  ...|.|.| | ...... ... | |. .  |.|||  ..
dllkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

EQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGEMFVNVRKVEKM-DEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNF
..| .  .|.  ..      . ..| ..|..|.||...|....||.. ...  ..|.||...| ..| ..... .|||  .|||  .|   . .  | ..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

VKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLN---DNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQKV
 | ...... || ...|.||.| ||..  ....|.    . .. | |.|| .|.|||.||..  ||  || .||...||| |... |....
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
subfamily_PTPN9_pd Subfamily PTPN9 139-406 2.2e-13 44.9 In-house 7-292 (297) alignment 
Range on Protein: 139-406
Range on HMM: 7-292/297.0
VAYIGKLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKP----DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAY
|||. . . .  . ||...   . .   ...  . || ||.      .| | |. . ..      |.| . |   .    ..  | | .   ..|||  .
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

NEQVV---MMYVLVGSEDEK-YDFFPKTTGSFLYYGEMFVNVRKVEKMDEER-SRYTIEVLPNGFSNsvMMNVYVHTGWEPFGVPIRY------ANTTRS
...|.   |.  .|     |   ..|....|   .|.. |.. .||.... . . ..|.   .. |    .  .  ..|  .|||          .. |.
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr..kvthfqflsWPdyGvPssaaslldvlekvre

----VVDVMNFV-KSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
    .|. .    |       ..|    | ||.| ||||  .   |.. .   . | || .|.||  ..   .||.  ||..| | ..
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
0047943 (Phosphotyrosine protein) phosphatases II 144-405 1.6e-47 157.7 In-house 8-273 (273) alignment 
Range on Protein: 144-405
Range on HMM: 8-273/273.0
KLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYV
.|. .. . |. ...  ..    .......|. ||.   ....| . || . ....|.| | | .....  ... | |. .  |.|||  ....| .  .
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LVGSEDE----KYDFFPKTTGS-FLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSE
|.  ..      . ..| . |. .|.||...|.....|. ..    .|.|. ..|...| ..... .|||  .|||  ..   . . .|... .......
LtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

KLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
. .| ...|.||.| ||.|  ....|. . .. . |.|| .|||||..|..  ||  || .||.|.|
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleylk
0051299 (Phosphotyrosine protein) phosphatases II 144-405 2.9e-40 133.9 In-house 19-287 (288) alignment 
Range on Protein: 144-405
Range on HMM: 19-287/288.0
KLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVK----DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVV
. . .. . |. ...  .  .  .......|| ||.   .. .| . ||    |.  ...|.| | . .....   .. | |. .  |.|||  ....| 
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

MMYVLVGSEDE----KYDFFPKttGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPN----GFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFV
.  .| . ..      . ..|   |..|.||...|. ...|. ...   .|.|| ..    | ..| . ... .|.|  .|||       . . .|... 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

KssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
.  .|.   .| ...|.||.| ||.|  ....|. . .. . |.|| .|.|||..|..  ||  .| .||.|.|
a..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_PTPN14_pd Subfamily PTPN14 144-406 2.3e-15 51.4 In-house 19-298 (300) alignment 
Range on Protein: 144-406
Range on HMM: 19-298/300.0
KLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQ-TDVYPILDATLVKDPAKP--DSYVNMSSVIVPHCS--YPILMGQIPKRGLEEEFWRAAYNEQV
||. ..  .||  .    .  . ...  ..|  ||.  || |  |. .   |.|   . |.| ||. |. ..  .  .. | | .   ..||.  ....|
kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv

VMMYVLVGS-E---DEKYDFFPKT--TGSFLYYGEMFVNVRKVEKMDEE-RSRYTIEVLPNGFSNSVMMNVYvhTGWEPFGVP------IRYANTTRSVV
 ..  |  . |   .  . .|||.    . . .|.  |  . .|. |    . .... || .   .|..  |  | |   |||      . | .  .|| 
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvr

DVMNFVKS-SNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
  .|  ..  . .  .||   .| ||.|  |.      .|. | |  | .... .| ||   |... ||  .|  |. |.|.
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_PTPN13_pd Subfamily PTPN13 145-405 2.5e-14 48.2 In-house 8-270 (273) alignment 
Range on Protein: 145-405
Range on HMM: 8-270/273.0
LDASQTRPEYIDVCVaTKaNIENCTVWKK--NLAKNQ-TDVYPIlDATLVKDPAKPDsYVNMSSVI--VPHCSYPILMGQIPKRGLEEEFWRAAYNEQvV
||  |   |. ..    |  ...|.| ||  | .||.  .| |. |.| ||  ..   |.| | .   | .  |  .. | |     ..||.  .. . .
ldqqqPaeefkelre.lk.pldtcevgkkkenkdknryrnvlPy.detrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk.a

MMYVLVGSEDEK-----YDFFPKTTGSFLYYGE-MFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKs
 . ..| .| ||       ..|..... |   . . |.. ||.|.|.   | ...|  .  ..|  .     . |   |||   |.  . |  | .. . 
eviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvr.alavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.

snGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
   .  ..|    | ||.| .||. ...  .. . |  . |||. .| ||   | . .||   |  .|. .|
..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 153-419 2.8e-19 64.4 In-house 27-300 (305) alignment 
Range on Protein: 153-419
Range on HMM: 27-300/305.0
EYIDVCVATK-ANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKP-DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLV----G
.|  ..   .  .... .. |.. . ... ...     | ... ..   |.| | |   . .   .. | | .   ..|||  ..|.|. .  |.    |
qykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveg

SEDEKYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiRYANTTRSVVDVMNFVKSSNGSEKLLVVSKN
 .|  . ..|....    .||. |...  ... .   |       .. ..|  .  |  | |   ||| ..| .  |... ..  ....    |||.  .
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvp.qfatsllslikrvqkdqkkdkgvpllVhCsa

GCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI--TVPEGLQQKVE
| ||.| ||..  |.  |.   .  . |..|..||.|...|.. .|| .|.  |  .|.      . . |. .|.
gvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 153-404 1.9e-16 55.1 In-house 28-284 (297) alignment 
Range on Protein: 153-404
Range on HMM: 28-284/297.0
EYIDVCVATKANIENCTVWKKN--LAKNQ-TDVYPIlDAT---LVKDPAKPDS-YVNMSSVivPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLV
.....    .||| . || .|.  . |.. ... |. |     |     .||| ||| | |  .   . ..  | |..   ..||.  ..||| .. .| 
fseeflclpeaniqpqtvaekkvnfeksRYkniLPy.dssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmln

G--SEDEKY-DFFPKTTGSFlyYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRyaNTTRSVVDVMNFVKSS---NGSEK
    .|.|   ...... .   .|.. | .  |..      | ..||  .   .  ... | .. |    |. .  ....|...... |. .   | .  
ddnerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikr.elevtkgkakarrvvkqyqfveWPdkaverk..dsassllklisevrkdfsqnaegP

LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYI
|||   .| ||.| ..|.    .  ... |  | ..|| .| .||. |   .||. .|  .| ..
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 154-408 1.6e-16 55.3 In-house 29-287 (319) alignment 
Range on Protein: 154-408
Range on HMM: 29-287/319.0
YIDVCVATKANIENCTVwKKNLAKNQTD-VYPiLDATLVKDPA---KPD-SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGsE
. ..  |.. ......  ..|  ||.   . .  | | |. ..   ...  |.| | .   .     .  | |.    |.|||  ..|.. .. .| .  
fkllkeavndtfdsask.eenkkknryqnila.ydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk.l

DEKYDF-FPKT--TGSFLYYGEMFVNVRKVEKMDE-ERSRYTIEVLPNGFSNsVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSN---GSEKLL
 || .  . |.  .  |  ||.. |.. . |.... . .. ... . .      ..  . .| |   .||    ....|..|... .. |     |  . 
veklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvP....ekatslldllkrirksrektqsgPiv

VVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI
|   .| || | ||.| |..  .. ..   . ..|. .| ||.  |.  .||  .|  || ...   
vhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPN23_pd Subfamily PTPN23 160-406 1.1e-19 65.4 In-house 29-282 (288) alignment 
Range on Protein: 160-406
Range on HMM: 29-282/288.0
ATKANIENCTVWKKNLAKNQ-TDVYPIlDATLVKDPAKPDSYVNMSSV--IVPHCSyPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEKY----
. .|.   ... |..  ||. .|. |  | . ||   . | |.| | |  ..| |  .... | |...   .||.  |.... .. .|.  |. .     
dkearkrsiaiaklyseknrsrdilPy.DhnRvklrgskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

DFFPKTTGSFLYYGEMFVNVRKVEKMDeERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFV-KSSNGSE-KLLVVSKNGCGR
 ..|. .|    .|.. | ...|.... . .......  .. ..  ..     | |  .|||    .  . .  | .   .  . |.  |.|    | ||
rYwPedkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

AGFFITLG-AAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
.| |  .  |.    ..|  . | ..|. .| || . |.  .|.  .|   | ....
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 161-407 1.5e-14 48.8 In-house 30-274 (288) alignment 
Range on Protein: 161-407
Range on HMM: 30-274/288.0
TKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSsvIVPHCSY--PILMGQIPKRGLEEEFWRAAYNE---QVVMMYVLVGSEDEK-YDF
 .|.|.  ... .| .... .  |  |.| ||    || |..    .|.   |   ..  | | .|  ||.|.   ..    .||.  |.    ||  ..
neasidiidsfianptrdryenlprcditrvklsddpdfyiaan..vvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaey

FPKTTGSFLYYGEMfVNVRKVEKMDEERSR-YTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRsvvdVMNFVksSNGSEKLLVVSKNGCGRAGF
||   |    .| .  .| |... | ..    ..    .   ..|.. .     |.  |||  |    |    ... .   .  . ..| |..| ||.| 
fPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr....llevl..kslqkPivvhssaGvGrtgt

FITL--GAAFCCLNDNSepRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.|     .   .|.|..   | ....  | .| .|... .||  .. |.|...  |
lililialeslrlddfl..girsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 161-406 1.1e-12 42.6 In-house 21-261 (267) alignment 
Range on Protein: 161-406
Range on HMM: 21-261/267.0
TKANIeNCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL-VGSEDEKYDFFPKTT
|...|  . . .|| ..|. |     | | |    | . |.| | |   .     .. |.| .    .|.    ...| .. .|    .|.   |.|   
tssti.sqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkm

GSFLYYGEMFVNvRKVEKmdeERSRYTIEVLPNGFSNSVMMNVYVHTgWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGA
|    | .. |. . .||   |   | | .|   | |    || ..  .. . .        . .. ..   .  ||.  |.|  ..| ||.| |... .
gqakkyqdltve.hslek...eendyqiitlelkfknesahnvtlyy.ykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvids

AFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 .  .  ..   | . .. |||||.  |..  .|  ..  |  | . 
qleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
0045450 (Phosphotyrosine protein) phosphatases II 165-407 7.4e-41 136.2 In-house 46-307 (307) alignment 
Range on Protein: 165-407
Range on HMM: 46-307/307.0
IENCTVWKKNLAKNQTDVYPILDATLVKDPA-----KPDSYVNMSSV--------IVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEK
  ... ...|  ||.   ....| | ||        ....|.|.| |         .....  ... | |. .  |.|||  ....| .   | .... .
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelg

Y----DFFPKTtGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPN-GFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKN
      ..| . |..|.||...|.....|. ...  ..|.|| .. | ..| . ... .|||  .|||   . . . .  |............ || .. 
rekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GCGRAGFFITLGAAFCCLNDNSE---PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
|.||.| ||..  . ..|... .   . . |.|| .|.|||.||..  ||  || .||....||
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllkk
0046845 (Phosphotyrosine protein) phosphatases II 167-411 8.4e-44 145.4 In-house 21-281 (284) alignment 
Range on Protein: 167-411
Range on HMM: 21-281/284.0
NCTVWKKNLAKNQTDVYPILDATLVKDPAKP-----DSYVNMSSVIVP-----HCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KY
.......|| ||.   ....| . ||    .     ..|.| | | ..     ...  ... | |. .  |.|||  ....| .  .| . ..      .
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

DFFPKTtGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNG-FSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRA
 ..| . |..|.||...|.....|. ..   ..|.|. ..|  ..|...... .|.|  .|||   ..  . . .| .. ....|... .| ...|.||.
qYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRt

GFFITLGAAFCCLNDNS---EPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVP
| ||.|  ....|. ..   .. . |.|| .|.|||..|..  ||  .| .||.|.|.|.|..
GtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
DSPc_SM00195 167-405 8.9e-42 138.6 In-house 19-263 (263) alignment 
Range on Protein: 167-405
Range on HMM: 19-263/263.0
NCTVWKKNLAKNQTDVYPILDATLVKDPA----KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKT
... .||| .||.   ... | | || .     ....|.| . . .....  . . | |.    |.|||  ..|.| . ..|.  |..     ....|..
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

TGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNG--SEKLLVVSKNGCGRAGFFIT
 |.   .|.. |....|||...|  ..|.|.  .| ...  ...| ...|.  |||    ..|.||......||.|.   |. ..|....|.||.| |.|
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp....dstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
.  .   |...... | ||||..|.|||..|.. .||. .| ..|.|||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 167-405 8.9e-42 138.6 In-house 19-263 (263) alignment 
Range on Protein: 167-405
Range on HMM: 19-263/263.0
NCTVWKKNLAKNQTDVYPILDATLVKDPA----KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKT
... .||| .||.   ... | | || .     ....|.| . . .....  . . | |.    |.|||  ..|.| . ..|.  |..     ....|..
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

TGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNG--SEKLLVVSKNGCGRAGFFIT
 |.   .|.. |....|||...|  ..|.|.  .| ...  ...| ...|.  |||    ..|.||......||.|.   |. ..|....|.||.| |.|
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp....dstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
.  .   |...... | ||||..|.|||..|.. .||. .| ..|.|||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
0040439 (Phosphotyrosine protein) phosphatases II 167-406 1.8e-40 134.5 In-house 4-248 (249) alignment 
Range on Protein: 167-406
Range on HMM: 4-248/249.0
NCTVWKKNLAKNQTDVYPILDATLVKDPA----KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKt
... ...|. ||.   ....| . ||        ...|.|.| . .....  ... | |  .  | |||  ..... .   |   .       . ..|  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

tGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLG
 |..|.||...|....||.  ..  ..|.|. ......|.. ... .|.|  .|||   . . . .  |...... . ....|| ...|.||.|.||.. 
.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 ....|. . .  . |.|| .|||||.||..  ||  || .||....|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 167-405 3.8e-38 126.7 In-house 2-244 (245) alignment 
Range on Protein: 167-405
Range on HMM: 2-244/245.0
NCTVWKKNLAKNQTDVYPILDATLVKDPAKP----DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKt
... ...|  ||.   ....| |.|| .  .    ..|.|.| | .....  ....| | ..  | |||  ..... .   |   |.      . ..|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

tGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKS---SNGSEKLLVVSKNGCGRAGFFI
 |..|.||...|.....|. ...  ..|.|| ..| . | . ..| ...|. .|||    .......|...||..   .......|| .. |.||.| ||
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvp....dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

TLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
..  ....|. . .  . |.|| .|||||.||..  ||  || .||...|
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 167-395 5.6e-12 40.1 In-house 26-257 (283) alignment 
Range on Protein: 167-395
Range on HMM: 26-257/283.0
NCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPH---CSYPILMGQIPKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKYD-FFPKtT
.... ..|  ||. .     |   |.  ... .|.| . ..| .    .   .. | | .    .||.  ..|..   ||.  |   ...|   ..||  
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.r

GSfLYYGEMFVNVRKvEKMDEERSRYTIEVLPNGF-SNSVMMNVYVHTGWepfgvpIRYANttRSVVDVM---NFVKSSNGSEK---LLVVSKNGCGRAG
||   |||. | .|| |   .  ..  . .  |.   .....  |   .|      . | .   .... .   | |.|    .|   ..|   .| ||..
Gs.edyGeftvtlrk.ettsnsfiikelllrvnssakstlllahyqvidW......leyge..qaiinslvkfnkvislqteskkgPivvhCstgiGrta

FFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYAS
 ||.. |.   .  .|   . ..|| .| ||. || .  ||  
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqykl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 167-403 4.4e-07 23.8 In-house 28-268 (281) alignment 
Range on Protein: 167-403
Range on HMM: 28-268/281.0
NCTVWKK--NLAKNQTDVYPILDATLV----KDPAKP-DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKY-DFF
 |||...  |  ||.    | || . |    | | |    |.    .  |      .. | ||.    .|||  ..|.   .||.  .. .. ||  ..|
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PKTTGSFLYYGEMFVNVrkvEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSsnGSEKLLVVSKNGCGRAGFFI
|. .   | . .. |.    |    ..|  |  .      .. ..  ..   |  . ||    ...  .. ..  ...   |   ..    | ||.| ..
prnahcclqfdklsvsy...edstvnkslvttrlnlsyegetrlithwlwkewpdwqvp....essevmlkilrkira..rstppvihcsagvgrsgtlm

TLGAAFCCLND-NSEPRIGEIVKAIRS-QRPNAVESIKQYASLYLCLLYY
..  |.  .    . | | .||  .|   |  .|....||  ..  || .
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 167-405 1.1e-06 23.0 In-house 34-278 (307) alignment 
Range on Protein: 167-405
Range on HMM: 34-278/307.0
NCTVWKKNLAKNQTDVYPILDAT--LVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL---VGSEDE-KYDFFPKTTG
.   .. |  ||. .  .  | .  .|| .     |.    . .      ..  | |.     .||  | .|.|  . .|   .        ...|   |
tveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

SFLYYGEM----FVNVRKVEKMDEERSRYTIEVLPNGFS-NSVMMNVYVHTGWEPFGVPiryaNTTrsvVDVMNFVKSSNGSEK-LLVVSKNGCGRAGFF
  | .||      |.   ..|.  .     .  |   .. .|  .. .  . |   |||    ..    .  .|.... .. .  ..|    | ||.|  
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvp....qin...ltainlleavrydtnpvvvhcsaGvGrsGti

ITLGAAFCC-LNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
...       ..      . ..|. .||||. |...  ||  |.  || |  
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl
0037934 (Phosphotyrosine protein) phosphatases II 168-404 1.7e-24 82.2 In-house 4-242 (243) alignment 
Range on Protein: 168-404
Range on HMM: 4-242/243.0
CTVWKKNLAKNQTDVYPILDATLVKDpaKPDSYVNMSSVIVPHcsYpILMGQIPKRGLEEE----FWRAAYNEQV---VMMYVLVGSEDEKYDFFPKttG
.  .. || ||.   .. .| . ||   ....|.| . . |.   . .  .| |  .  |.    |||  .....   ||.  ||  . ||.. .    |
iallpenlsknrysdilpydhsrvkl..egsdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

SFlYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKS------SNGSEKLLVVSKNGCGRAGFF
.. .||...|.. ..| .|.   |.   . ..    . .   | ...|  .|||   ..  . . .| .|...       ......||  . |.||.| .
ev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

ITLGAAFCCLndnsEPRIGEIVKAIRSQRPN-AVESIKQYASLYLCLLYYI
|..     .|    .  . |.|| .|.|||. ||..  ||  || .||...
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 168-406 6.8e-24 80.2 In-house 27-274 (278) alignment 
Range on Protein: 168-406
Range on HMM: 27-274/278.0
CTVWKKNLAKNQTDVYPILDATLVKdpakpDsYVNMSSVIVPhcSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE---K-YDFFPKttGSFL
. .. .||.||    .. .| . ||     | |.| | . ..  .   .. | |.    . |||  .....     | . ..    | . ..|   |..|
palylgnldknRykdilpydhsrVk.....d.YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsl

YYGEMFVNVRKVEKMdEERSRYTIEVLPN----GFSNSVMMNVYVHTGWEPFGVPIRY-ANTTRSVVDVMNFVKS------------SNGSEKLLVVSKN
.||...|.. ..| . ..    |..|           |  ....  ..|. .|||     .   .... .. . .             ..... ||  . 
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GCGRAGFFITLGAAFCCLndNSEPRIGEIVKAIRSQRPN-AVESIKQYASLYLCLLYYIKK
|.||.| .. .    ..|  ..   . |.|| .|||||. ||..  ||  || .||.....
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN3_pd Subfamily PTPN3 171-400 8.8e-15 49.4 In-house 38-271 (280) alignment 
Range on Protein: 171-400
Range on HMM: 38-271/280.0
WKKNLAKNQ-TDVYPiLDATLVKDPAKPDSYVNMSSVIVPHCSYPI----LMGQIPKRGLEEEFWRAAYNEQVVMM---YVLVGSEDEK-YDFFPKTTGS
  .||.||.  |. |  ||| ||  . .  |.| . | .   |  .    .  | | .   ..||.  ..... ..     || .   | . ..|.|. .
kpenlsknryrdilp.ydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetede

fLYYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSngSEKLLVVSKNGCGRAGFFITLGAAF
 | |||. |...| ..  .   |  . .  .  ... ..    .. |   |||   |.  . |  | .  ...  .| ..|    | ||.| .|.|  |.
.leygefsvkcekedetksyvlr.elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk..eePvvvhCsaGigrtGvlilletal

CCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCL
. .. . .  . .||. .| || . |.. .||  .  ..
alieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 171-404 1.6e-09 31.8 In-house 44-279 (303) alignment 
Range on Protein: 171-404
Range on HMM: 44-279/303.0
WKKNLAKNQTDVYPILDATLVKdpAKPDSYVNMSSVIVPhCSYPILMGQIPKRGLEEEFWRAAYNEQVVM-MYVLVGSEDEKY--D-FFPKTtGSFLYYG
. ||. ||.      || . ||      ||.  | . .  .|   .. |.|      .||.   ...|   . .|  || .|.  |  ||.    || . 
fvknmdknrfvdvicldhskvk..lsdssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkfe

EMFVNVRKVEKMDEeRSRYTIEVL--PNGFSNSvMMNVYVHTGWEPFGVPIR-YANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCC
| .. | .  ...     ... ||   ||  .| .. |. .  |    .|    ..  . . ..  ...    |.  . .|  |||||| |  . .|   
ersirvgefkrvel.gdgwvlkvlsvsngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

LND-NSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYI
| . ..   .   .. .|  |  ||. . |.. .|  |  ..
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 172-407 1.3e-08 28.9 In-house 53-292 (305) alignment 
Range on Protein: 172-407
Range on HMM: 53-292/305.0
KKNLAKNQTDVYPILDATLVK--DPAkPDSYVNMSSVIVPHCS-YPILMGQIPKRGLEEEFWRAA---YNEQVVMMYVLVGSEDEKY-DFFPKTTGSFL-
. . .||. .  |  | ..||  .|. |  |.    | .|      ..  | |     .|||        ||.||.   |     |  ...| . |  | 
diaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

-YYGEMFVNVRKVEKMDEErSRYTIEVLPNGFSNSVMMNVY--VHTGWEPFGVPIryanTTRSVVDVMNFVKSSNGseKLLVVSKNGCGRAGFFITLGAA
   | .  ||     |. . .   | .|   .| .  | |     | |   |||        . ....  .. |.    ..|    | ||.|  ...   
lksgivvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewpdrgvpp....ckltslellsairgskv..pivvhcsagigrtgtivaieyi

FCCLNDNSE-PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.  . .| . | . |.|||.| ||  ....  ||  ..  .| |. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_PTPRB_pd Subfamily PTPRB 173-407 2.5e-17 57.9 In-house 50-288 (293) alignment 
Range on Protein: 173-407
Range on HMM: 50-288/293.0
KNLAKNQTDVYPILDATLVKD----PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYD-FFPKTTGSFlY
.| |||.       |.. ||       . . |.| . .   ..    .  | |  .  ..|||  ....   .||.  ||    .| . ..|... .  .
vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.l

YGEMFVNVRKVEKMDEERSRyTIEVLPngFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFV----KSSNGSEKLLVVSKNGCGRAGFFITLGAA
||.. |.. . |....   | ....     ...  .. | .| |  .|||    ..|....| .. |    .... .. ..|    | ||.| ||.|   
yGdikvtlvaeeeledwvir.elkiek..ekeerkvrqyhftsWpdhgvP....ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl

FCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.  ....    |  || ..|..| . | . |||  .. |.| ...||
lqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
Y_phosphatase Protein-tyrosine phosphatase 174-401 2.5e-39 130.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 174-401
Range on HMM: 1-234/235.0
NLAKNQTDVYPILDATLVKD--PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGE
|. ||.   ... | | ||     .|  |.| . |   . .  ... | |     |.|||  ..|.| . ..|.  |..      ...|.... .|.||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MFVNVRkvEKMDEERSRYTIE--VLPNGFSNS--VMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAF
..|...  ||  |. ..||..   | .  ..|   ..... .|.|.  |||    ....|..|... |..|.   |....|....|.||.| |..| ...
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
..|....|. . .||| .|.|||..|.|..||. || ..|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 174-401 2.5e-39 130.5 In-house 1-234 (235) alignment 
Range on Protein: 174-401
Range on HMM: 1-234/235.0
NLAKNQTDVYPILDATLVKD--PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGE
|. ||.   ... | | ||     .|  |.| . |   . .  ... | |     |.|||  ..|.| . ..|.  |..      ...|.... .|.||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MFVNVRkvEKMDEERSRYTIE--VLPNGFSNS--VMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAF
..|...  ||  |. ..||..   | .  ..|   ..... .|.|.  |||    ....|..|... |..|.   |....|....|.||.| |..| ...
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
..|....|. . .||| .|.|||..|.|..||. || ..|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Ptp69D_pd Subfamily Ptp69D 174-407 5.9e-15 50.2 In-house 48-289 (307) alignment 
Range on Protein: 174-407
Range on HMM: 48-289/307.0
NLAKNQTDVYPILDATLVKDP----AKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYnEQVVMMYVLVGSEDEKYD-----FFPKTtgSFLY
|. ||. .     | | || .     .  .|.| | ..  . .   .. | |  .  ..|||    || | . |..  ..|| .     ..|.       
nalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia.eqevtlivmlsnlteknrkkcakYWpie..devq

YGEMFVNVRKVEKMDEERSRyTIEVLPNG-----FSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSngSEKLLVVSKNGCGRAGFFITLGA
||.. |.. . ||...   | ...|  ..       .|  .  | .|||. . ||       . .  | .  | .     ..|  ..| ||.| |..|  
ygdilvklvseekhsdyiiR.eldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvalds

AFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
 .  |. . .  | |.|| .||||.  |.|..||  ||  || |... 
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
0041856 (Phosphotyrosine protein) phosphatases II 174-411 6.6e-14 47.4 In-house 1-178 (182) alignment 
Range on Protein: 174-411
Range on HMM: 1-178/182.0
NLAKNQTDVYPILDATLvkdpakPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgseDEKYDFfpkttgsflyygemfvnvr
|| || .  ..  | ..      . .|.| . .. .. .  ... | |  .  ..|.|  ..... .   |    .| |.                    
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywp...................

kvekmdeersrytievlpN-GfsnSVMMNVYVHTGWEPFGVPIryantTRSVVDVMNFVKSsnGSEKLLVVSKNGCGRAGFFITLGAAFCClndnsEPRI
                  .       .   |....|. .|||      .....| .. |..   ... ||  . |.||.|... .    ..     .  .
..................ell...erlgiqylylpwpDhgvpd.....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

GEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVP
 |.|| .||.||..|..  ||  |.|.||.... |.|.|
eeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 174-404 1.9e-10 34.7 In-house 45-236 (392) alignment 
Range on Protein: 174-404
Range on HMM: 45-236/392.0
NLAKNQTD-VYPI--LDATL-VKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSED-Ekydffpkttgsflyygem
|| ||. . . |.      | | |    . |.| | .   ..    .  | |.    ..|||  ..|.|  . ..   .. .                  
nlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..................

fvnvrkvekmdeersrytievlpNGFSNSvMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGSEK--LLVVSKNGCGRAGFFITLGAAFCCLND
                       .| ..   .  .  | |   .||    . | |.. ... ||.  |.    |..    | ||.|  |.. .  .  . 
.......................kgddar.tvaqfhftewPdkdvp....khtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakk

NSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYI
     . ..|  || .||  |.. .||| .| ..|  .
trmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_PTPN1_pd Subfamily PTPN1 174-417 7.1e-08 26.5 In-house 32-283 (290) alignment 
Range on Protein: 174-417
Range on HMM: 32-283/290.0
NLAKN-QTDVYPIlDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEK-YDFFPKTTG-SFLYYGE
| ..|   || |  | . .|   .   |.| | | ...     .. | |     . ||.  ....   |||.  .|  |  | ....|.    . | . .
nrnlnryrdvspy.dhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellled

MFVNVRKVEKmdEERSRYTIEVL--PN-GFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCL
. ..|. ...  |..| ||...|   |    ..  .  . .| |  ||||   |.  . . .| .    |.     ..    | ||.| |. . . .  .
tklkvklise..erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli

NDNSE---PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKkKITVPEGLQQK
... .     | . . ..|..|   .   .|    || .|  .| .|. .  .|..
ekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak.vikgdssvqkr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 176-403 1.7e-12 41.6 In-house 58-282 (290) alignment 
Range on Protein: 176-403
Range on HMM: 58-282/290.0
AKNQTDVYPILDATLV--KDpAKPDSYVNMSSVivPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYV---LVGSEDEK-YDFFPKTTGSFLYYGEMF
 ||.    .  | | |  ||   .  ||    |       .... | . .    ..||   .|.| .. .   |.     |  ...|.. |  | .||. 
kknrykdvvcndktrvilkd.GydGdyvhanyv..kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

VNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVpiryANTTRSVVDVMNFVKSSNGSekLLVVSKNGCGRAGFFITLGAAFCCLNDNSE
|   . .. |..  . |. |       . ... .    |    |    |..| ... ..  ..  .|   . |    | ||.| |... ..  .| |  |
vlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv....alstlallrtlrilrkasGp..vvvhcsaGiGrtGtfvaievglqilldGke

PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY
 .. ..|.|.|  | |.|.   ||  |   || .
ldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 176-405 1.3e-08 28.9 In-house 40-278 (287) alignment 
Range on Protein: 176-405
Range on HMM: 40-278/287.0
AKN-QTDVYPILDA--TLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL---VGSEDEK-YDFFPKTTGSFLYYGEM
 ||  .|| || |.   |.... .  .|.|   |   .     .  | |      .|||| .....  . ..   |     | | ..|.     .  |  
kknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGys

FVNVrKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDV---MNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLN
 | . . .... | .  .. ..     .. ... .    |   ...       | |.||   ..  .....   |.|  . | ||.| .... .    |.
vvll.dydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrle

DNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
|  .  .  .|  .| .|   | .. |.  ||  |  | |
dlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 177-417 2.1e-07 25.0 In-house 51-300 (305) alignment 
Range on Protein: 177-417
Range on HMM: 51-300/305.0
KNQTDVYPILDATLVK-DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSED----EKYDFFPKTTGSFLYYGEMF--
||.      ||   || ... |  |.    |  |  .  ..  | |      .||   ....| ....|    .      ...|.   .  | . |    
knrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk

--VNVRKVEKM---DEERS--RYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGSekLLVVSKNGCGRAGFFITLGAAFC
  | .   ...   .. ..  . |. |.    ...  .. |    |   |||     .  .......  ..| |   . |    | ||.|  . |   . 
isvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvp....aadlailellekarpskgp..ivvhcsagigrtgsvvmleyild

-CLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQK
  |. .       |.. || || |.... .||  ..  .| |..||  . |  .. 
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea
subfamily_PTPN12_pd Subfamily PTPN12 190-410 7.7e-16 52.8 In-house 59-283 (290) alignment 
Range on Protein: 190-410
Range on HMM: 59-283/290.0
LVKDPAK-PDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSR
| |.  .  ..|.| ...  .. .   .  | |     ..|||  .. .|   ||.  .|  .  |   ..|..... | .||. |.. . ...|..   
lskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddfli

YTIEVLPNgfSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEP---RIGEIVKAIRS
 |..|  .  ..| ... . .| |   ||| .  .  . . .| .. .  . .. |.|    |.||.|  |..  .   |...  |    . ..|  .| 
rtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrk

QRPNAVESIKQYASLYLCLLYYIKKKITV
||. .| . .||  .| ... ...|....
qraalvqtkeqyelvykavaelvqkelei
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 191-434 1.4e-17 58.5 In-house 65-309 (315) alignment 
Range on Protein: 191-434
Range on HMM: 65-309/315.0
VKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLV-GSEDEK---YDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYT
| |    . |.| | .   ..    .  | |..   ..|||  ..|.|  . ..   .|..|     ..|.  .    .|.. |.. ..|   .   |  
viddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl

ieVLPNGfSNSVMMNVYVHTGWEPFGVPIRYAnttrSVVDVMNFVKSSNGSEK--LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRP
  |. ..  .|  .  .  |.|   ||. . .    |.. ..  ||..||...  |||    | ||.| .|..      .....   . ..|| .|..||
..vtrks.eesrtvtqfqftewPdkGvdkqts....sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrp

NAVESIKQYASLYLCLLYYIKKKITV--PEGLQQKVEDLKRGLEGITREDLT
  | . ..|| .|  .| ... . |.     . ....||.   .|  |  .|
ylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 191-406 3e-12 41.1 In-house 64-280 (287) alignment 
Range on Protein: 191-406
Range on HMM: 64-280/287.0
VKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVG----SEDEKYDFFPKTTGsfLYYGEMFVNVRKVEKMDEeRSRYT
|    . . |.| . .   . ..  .. . |      .||.   ...|  . .|.      |.  |...|...   ...||  ... . |....     .
vllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnag.yierk

IEVLPNG-FSNSVMMNVYVHTGWEPFGVpIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPN
.||  ..  ..  ... |  | |.  |  .   .|   |.. |.  .  .|   ..|   .. ||.. |.    .    . .    . ...|  | |.|.
levknknkagdkqqvkqyqitnWdstgk.vtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpg

AVESIKQYASLYLCLLYYIKK
.|  ..||  ..  .| |.. 
svqtveqykfindivleylds
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 193-433 1.3e-17 58.1 In-house 66-307 (515) alignment 
Range on Protein: 193-433
Range on HMM: 66-307/515.0
DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL-VGSEDEKY---DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRyTIE
. .    |.| | .   ..    .  | |..   ..|||  ..|.|  . ..   .|..|     ..|.  |  . .|.. |..  .|   .   | ...
ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikr.klt

VLPNGFSNSVmmNVYVHTGWEPFGVPIRyantTRSVVDVMNFVKSSNGS--EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNA
|| .  |. |    .  |.|   ||| .    |.|.. ..  ||...|     |..    | ||.| .|..       ..     . ..|. || .||  
vlkgddsrtv..tqfhfteWPdkGvpkh....tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpyl

VESIKQYASLYLCLLYYIKKKIT-VPE-GLQQKVEDLKRGLEGITREDL
|    ||| .|  .| ... . | .|   . ....||.   .|  |  .
vqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskm
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 193-404 3.8e-11 37.1 In-house 70-279 (439) alignment 
Range on Protein: 193-404
Range on HMM: 70-279/439.0
DPAKPDS-YVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgSEDEKYDFFPKTTGsfLYYGEMFVNVRKVEKMDEERSRyTIEVLP
 |  | | |.|   .   .     .  |.||.   ..|||  .....| . .|     | | ..|  .    .||.. | | .  .. .   |  . |. 
ipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt.nlvesykywpsdae..vcygdiavrvdrnielpnyvir.gfkvfn

N--GFSNSVMMNVYVHTGWEPFGVPIRyantTRSVVDVMNFVKSSNGSEK---LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNA
.     .   .  . .. |    || .    .  |.| .  ..|.| .|.   ..|    | ||.|  |.|  |.  |. . .  |  ||| .| || . 
erdttekertvlqfhyiawpdknvpaq....ashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqm

VESIKQYASLYLCLLYYI
|... ||  .| ..|  |
vqalcqyvfiynavledi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 194-405 2.2e-20 67.9 In-house 71-280 (288) alignment 
Range on Protein: 194-405
Range on HMM: 71-280/288.0
PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVl
  .   |.| | . . . .   .  | |     ..||.  |...   .||.  ||  ...| . .  ...    ||.. | .........   |  . . 
eeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.

pnGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGSE--KLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVE
     . . .. | ...|   |||    . .. ...... || .| ..  ...|.  .| ||.| ||.| |.   .. .    . ..|. .| ||.. |.
..kkkteleitqyqylaWpdhgvP....eskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvq

SIKQYASLYLCLLYYIK
  |||  .| .||  |.
tlkqYefiyevllslie
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 196-405 3.2e-18 61.0 In-house 82-291 (298) alignment 
Range on Protein: 196-405
Range on HMM: 82-291/298.0
KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKY-DFFPKTTGSflYYGEMFVNVRKVEKMDEERSRyTIEVLP
.   |.| | .   . . . .. | |     |.|||   .|.   .||.  |. ..  ||  ..|..      |||. |.... |.. .  .| ...|  
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivr.klkvsk

NGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFV---KSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVE
.  ... ..    .| |   |||    ....||.|... |   .. .| . ..|   .| ||.| || . . .  .. ..   . ..||..| .||.||.
kkeekerevrqlhftsWpdkgvp....enatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavq

SIKQYASLYLCLLYYIK
. .||. .|   | ...
teeqYvfiyeavleald
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 196-406 1.2e-12 42.4 In-house 71-285 (290) alignment 
Range on Protein: 196-406
Range on HMM: 71-285/290.0
KPD---SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVG-SEDEK---YDFFPKTtGSFLyYGEMFVNVRKVEKMDeERSRYTIE
..|   .|.| . .   . ..  .. | |      .||.  ..|.| .. .|.   |..|   . ..|.. ..   |||. ... . |... |  . ..|
hkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierkle

VLPNGF-SNSVMMNVYVHTGWEPFGvPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAV
|  .    .. ..  |  | |.. |  .   .|  .|.  |.  .  .| . ..|   .. ||.. |...  .    . .    . ...|  |.|.|. |
vknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsv

ESIKQYASLYLCLLYYIKK
.. .||  ..  .| |...
qtvqqyqgifqivltylds
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 196-405 3.4e-09 30.8 In-house 68-294 (301) alignment 
Range on Protein: 196-405
Range on HMM: 68-294/301.0
KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERS--------
.  .|.| | .     .    . | | .    .|||  ..|..| . .. . ...     . ..|... .  ..|.. | . .   . .           
cqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq

-----RYTIEVLPNGFS-NSVMMNVYVHTGWEPFGVpIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVK
      |..  .    . .|  .  .  | |   || .|  .|   |.| .   . . |  ...|   .. .|.| ....  .      .    . ...|
dgsnngyierkfkvksdksswdvlqlqvtdWpqdGv.vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtk

AIRSQRPNAVESIKQYASLYLCLLYYIK
|.| ..| ||  ..|| |.|  .  |..
avrrskpgaVtTLeqytsiydvidmylq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 197-405 3.2e-19 64.1 In-house 36-243 (250) alignment 
Range on Protein: 197-405
Range on HMM: 36-243/250.0
PDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNE---QVVMMYVLVGSEDEKYDFFPKTTGSflYYGEMFVNVRKVEKMDEERSRyTIEVLPNG
   |.| | . . . .   .. | |     |.|||  ..|    .||.  |. || .  ...|  .     ||.. |.. . |.. .  .| .. .  . 
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae..kyGdvtvsllskeefadytkr.klklskak

FSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGS---EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESI
 ......  . .. |   |||    .....|..... |..|.       ..|   .| ||.| ||.. | .  |. .    . ...|..| .||.|||| 
kaderivrqlhfvvWPdkgvP....evatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl

KQYASLYLCLLYYIK
.|| ..|  .| ...
eqyvfvyeiilkald
subfamily_CG7180_pd Subfamily CG7180 198-404 7.2e-14 46.1 In-house 70-290 (296) alignment 
Range on Protein: 198-404
Range on HMM: 70-290/296.0
DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEK--Y-DFFPKTTgsFLYYGEMFVNVRKVEKMDEERSRyTIEVLPN--
. |.| . |         .. . ||.   .||||  |.|..  . ||    | .  | ...|...     |||.||.. ..... . ..| |. .  .  
sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkir.tfkltkkiv

--G-----F-SNSVMMNVYVHTGWEP-FGVPIR---YANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIR
  .        .  .. ..  | ||    ||.    . .  | |  ... |.  .  . ..|||..| .|.| .... |.   .. . |  . | || .|
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

SQRPNAVESIKQYASLYLCLLYYI
 .||. ||....|  .|  || ..
rsRpqLvenveeYkyiYdvlleav
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 198-407 2.4e-12 41.6 In-house 69-279 (281) alignment 
Range on Protein: 198-407
Range on HMM: 69-279/281.0
DSYVNMSSVIVPH--CSYPILMGQIPKrgLEEEFWRAAYNEQVVMMyVLVGSEDEK-----YDFFPKTTgSFLYYGEMFVNVRKVEKMDEErSRYTIEVl
  |.| . |   .    | .  | .|.    ..||.  ....| .. |.|  | |.     . ..|  . | | ||.. |.  . |.  .   . .... 
tDYinanfvpgykgekeyiatqgPvPa..slvafWqmvweqkvsai.vmvtreieagklkChrYWPddn.selkygdvtvkstaeeekaty.ierkfkl.

PNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKS---SNGSEKLLVVSKNGCGRAGFFITLGAAFCCL-NDNSEPRIGEIVKAIRSQRPNA
 .  .... ..   .| |   |||    .||. ...  . |..   ..    |..    | ||.| .|.|  ..  . ....|  . ..|. .| .|   
eresgetreveqlaytaWPdhGvP....attkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlm

VESIKQYASLYLCLLYYIKKK
| .. ||. .|. .| ...|.
vqtvvqyefvykavldaldke
0043147 (Phosphotyrosine protein) phosphatases II 198-397 7.4e-11 37.6 In-house 5-154 (172) alignment 
Range on Protein: 198-397
Range on HMM: 5-154/172.0
DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSedekydffpkttgsflyygemfvnvrkvekmdeersrytievLPNGFSNS
. |.| | . ....   ....| | |   ..|||  ..... . . | .                                           | ..   .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpelle

VMMNVYVHTGWEPFGVPirYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLndnsepRIGEIVKAIRSQRPNAVESIKQYASLY
 .   | ...|. .|||   ..  ..... .. .   . ... ||  . |.||.|... .    ..|       . |.|. .|..||.||..  ||  ||
rlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 198-401 5.5e-07 24.0 In-house 46-257 (290) alignment 
Range on Protein: 198-401
Range on HMM: 46-257/290.0
DSYVNMSSVIVPHCSYPILMgQIPKR-------GLEEEFWRAAYNE---QVVMMYVLVGSEDEKYD-----FFPKTTGSFLYYGEMFVNVRKVEKMDEER
| |.  . |..|.    ||. | |.           |.|| .| .|   ||||.      . .. .     ..|.. |  | .. . |.  . || |.  
ddyiHAnrvtcpnglrlilt.qsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

SRyTIEVLPNGfSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGseKLLVVSKNGCGRAGFFITLGAAFCCLN-DNSEPRIGEIVKAIRS
 | ...|  ..  .   .. .   ||..  |.    ..|.........|| |.     .|  ..|  |   . ..  ..  .   ...  . ...||.|.
tR.elvvkfdd.eeeftvtHsllkgWnklnvq....edtktllsliqkvkaskt..pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRPNAVESIKQYASLYLC-LL
|| .|. | ...|      .|
qralaitsalelafvdagivl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 199-410 4.2e-21 70.4 In-house 77-295 (325) alignment 
Range on Protein: 199-410
Range on HMM: 77-295/325.0
SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAA--YNEQVVMMY-VLVGSEDEKYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSR-YTIEVLPNGF
 |.| | .         |  | |.    ...|| .  ..  ||..  .| . .|.   ..||  |    .| . |..| .|.. .   | . .    .| 
dyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe

SNSVmmNVYVHTGWEPFGVPIR---YANTTRSVVDVMNFVKS-SNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESI
. ||  . . . .|. .||. |    .. .. |  | . |.. ...|  .||   .| ||.| ||.| .|   . ..|.  | . || .| .||. ||..
trsv..kqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

KQYASLYLCLLYYI-KKKITV
 ||  .| .|  ..   .  |
dqyiliyealveaymsgntdv
subfamily_PTPRK_pd Subfamily PTPRK 199-401 1.4e-16 55.2 In-house 72-274 (314) alignment 
Range on Protein: 199-401
Range on HMM: 72-274/314.0
SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSE-DEKYDFFPKTTGSflyYGEMFVNVRKVEKMDEERSR-YTIEVLPNG
 |.| . .   . .   .. | |..   ..|||  |.|.   .||.  ||     . . ..|. |     ||.. |.. ..|   |  .| ...| |  |
dyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklarg

FSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSsnGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQY
 ..  ... . ..||  ..||       . |  | .  .   .  ...|   .|.||.| ||..      .. ..   . ..||..||...| ||  .||
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy

ASLYLCLL
  .|  .|
kfiydvil
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 199-401 4.5e-14 47.1 In-house 78-276 (315) alignment 
Range on Protein: 199-401
Range on HMM: 78-276/315.0
SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYD-FFPKTtgsFLYYGEMFVNVRKvEkmdEERSRYTIEVLPNGF
 ||| . .         .  | |.    ..|||  ..|.   .||.  ||  | .| . ..|      . ||.. |  .. |   |  ..||.  |   |
dyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrks.e...evnteytvrtlsvvf

SNSVMMNVYV-HTGWEPFGVPIRYANTTRSVVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQY
 . .   | . .| |   |||    .    .  |. . ..|     ..|  ..| ||.| |||| | .  .. .    . .... .|..| ..|....||
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy

ASLYLCLL
  .|  ||
qfiydall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 200-402 4.9e-15 50.8 In-house 55-253 (284) alignment 
Range on Protein: 200-402
Range on HMM: 55-253/284.0
YVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgsEDEKYDFFPKTTGsfLYYGEMFVNVRKVEKMDEeRSRYTIEVLPNGFSN-SV
|.| | .         .  | |.    ..|||  .. ..  . .|   .|   ...|. .     .... |.|  ||. .|      ||.  .|  .   
yinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkiv..ikeerfkvkvdsveesee.yvvrdielsedgkekdir

MMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYL
 .. .   ||   |||   ..  | |  |  . .  |. ....|    |.||.| .|.| . .  .....   . ..|. .| ||.. |... ||  .| 
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLLY
 || 
alle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 200-402 6.1e-15 50.3 In-house 91-289 (319) alignment 
Range on Protein: 200-402
Range on HMM: 91-289/319.0
YVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgsEDEKYDFFPKTTgsFLYYGEMFVNVRKVEKMDEeRSRYTIEVLPNGFSN-SV
|.| | |         .  | |.    ..|||  .. ..  . .|   .|   ...|. .     .... |.|  ||. .|      ||.  .|  .   
yinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplki..vikeerfkvkvdsveetae.yvvrdielsedgkekdir

MMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYL
 .. .   ||   |||   ..  | |  |  . .  |. ....|    |.||.| .|.| . .  .....   . ..|. .| ||.. |... ||  .| 
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLLY
 || 
alle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 200-405 1.7e-10 35.4 In-house 61-271 (285) alignment 
Range on Protein: 200-405
Range on HMM: 61-271/285.0
YVNMSSVIVPHCSYP-ILMGQIPKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVE--KMDE-ERSRYTIEVLP
|.  | . .|       .  | |      .||.  |.|..   .|.  |.    ||   ..|.  |  . .|.  . . ...   .        |.    
yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvinte

NGFSNSVMMNvYVHTGWEPFGVPiryANTTRSVVDVMNFVKSSNGSEKLLVV-SKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESI
.  |. . || .|.  | |  .     . .| .... ..||  |  || ..|    | ||.  |. .  |   . .| .  . .||. .|. | .||.| 
dasseplymn.hvqvpwwpdqla...pedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh

KQYASLYLCLLYYIK
 |.  ||. |. |. 
mqflflyvvlmeyfi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 200-403 1.4e-06 22.4 In-house 61-294 (297) alignment 
Range on Protein: 200-403
Range on HMM: 61-294/297.0
YVNMSSVIVPHCSYPI--LMGQIPKRGLEEEFWRAAYNEQVVMM---YVL-VGSEDEKYDFFPKTTGSFLYYGEMFVNVrkVEKMDEERSRYTIEVLPNG
|.|   |. |.   ..  .. | | .   ..||.  ....| ..     |  .  |  . ..|.. .  |  |.. |.   . .. .|  |  .  |   
yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvef..lsstsdefdrviltelqli

F-SNSVMMNVYVHTGWEPFGVP------IRY-A---------NTTRSVVD---------VMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN
. |.| ...   . .|   |||       |. |             ..|.         .  .      .  |||    | ||.|  .   .    |  .
yrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk

SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY
  | .  |.. .|.||.  |....|.  ||   |  
ripdvaailsilreqrarlvqtleqfellydavlkk
0044763 (Phosphotyrosine protein) phosphatases II 205-406 5.3e-08 28.2 In-house 24-173 (178) alignment 
Range on Protein: 205-406
Range on HMM: 24-173/178.0
SVIVPHcsyPILMGQIPkrgleEEFWRAAYNEQVVMmYVLVGSEDEK-----YDFFPKTTGsflyygemfvnvrkvekmdeersrytievlpngfsnsvm
| |.|.    .|... |     .....  ... . .  | . .|.|      .  .|. .|                                       
seilpg...lylgslpp.....addlellkelgith.ivnlteelelgflkcdpywpeeag.......................................

mNVYVHTGWEPFGVPIrYANTTRSVVDVMNFVKSSNGsEKLLVVSKNGCGRAGFFItlgAAFC---ClndnsEPRIGEIVKAIRSQRPnAVESIKQYASL
   |.|.... .|||      .. .|. .. . ...| .. ||  . | ||.| ..   ||.    .        . |... .|..|| .|..  |.  |
.iqylhipipDhgvpd.llehflefvefieealdekg.gpvlVHCsaGvgRsgtlv...aaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqL

YLCLLYYIKK
|.. |.. |.
yefelrllke
0049260 (Phosphotyrosine protein) phosphatases II 212-397 2.1e-09 32.8 In-house 8-143 (152) alignment 
Range on Protein: 212-397
Range on HMM: 8-143/152.0
SYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEKYDFFPKTTgsflyygemfvnvrkvekmdeersrytievlpngfsnsvmmnVYVHTGWEPF
..... .| | .   ..|||  .. ..    .|   .. .......                                             | |. |. .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPIRYANTTRsVVDVMNFVkSSNGSEKLLVVSKNGCGRAGFFITLGAAFcclndnSEPRIGEIVKAIRSQRPNAVESIKQYASLY
|||         .......    . ... ||  . |.||.|... .              . |.|. .|..||.||..  |.  ||
gvpdlsqlllf.lllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPRA_pd Subfamily PTPRA 214-404 1.1e-16 55.6 In-house 102-296 (330) alignment 
Range on Protein: 214-404
Range on HMM: 102-296/330.0
PILMGQIPKRGLEEEFWRAAYNE---QVVMMYVLVGSEDEKYDFFPKTTGSFlYYGEMFVNVRKVEKMDEERSR-YTIEVLPNGF--SNSVMMNVYVHTG
  .  | ||.   |.|||  ..     .||.  |   ..||   .  . |..  ||.. |.|.... . .   | . .. ||..    .| ... .  |.
kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhfts

WEPFGVPIryanTTRSVVDVMNFVKSSNGS--EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY-I
|  .|||.    ... ...... ||. |    . . |    | ||.| ||.| | .  .. .    . |.|| .| |||. | . .||  .|  || | .
wPdvGvPf....epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
0051429 (Phosphotyrosine protein) phosphatases II 215-414 1.2e-11 40.4 In-house 24-235 (272) alignment 
Range on Protein: 215-414
Range on HMM: 24-235/272.0
ILMGQIPKRGLEEEFWRAaYNEQVVMMYVLVGSE---DEKYDFFP-----------KTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMM
.. .. | .  ...|||  ..... .   | . |    .|.|...            ..  .  || ..| . ..| ..    |. . .|  . ... ..
lyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

NVYVHTGWEPFGVPIRYanttrsVVDVMNFVKSsngSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPR--------IGEIVKAIRSQRPNAVESIKQ
 ....|.|  .|||  .      ........ .   ....||  . |..| |... |      ....            . |.|. .|.|||.||..  |
mhlhytdwpdhgvpqea......llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeq

YASLYLCLLYYIKKKITVPEGL
|. || .|| .... ..|..  
ylflyeallellrsllsvraey
0036282 (Phosphotyrosine protein) phosphatases II 215-397 2.9e-11 38.8 In-house 19-163 (174) alignment 
Range on Protein: 215-397
Range on HMM: 19-163/174.0
ILMGQIPKRgleeeFWRAAYNEQVVMMYVLVGSEDEK----YDFFPKttgsflyygemfvnvrkvekmdeersrytievlpNGFSNSVMMNVYVHTGWEP
.. || | .     ||.  ..... .   |  ..  .    ....|                                   .  . . .   |....|. 
liagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lredlerlgiqylylpwpD

FGVPIRYAntTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNdNSEPRIGEIVKAIRSQRPNAVESIKQYASLY
.|||       ...|. .. . |.... ..||  . |.||.|... .    ..|  .|   . ..|...|.|||..|..  ||  ||
hgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_PTPRG_pd Subfamily PTPRG 216-422 2.2e-12 41.0 In-house 94-303 (563) alignment 
Range on Protein: 216-422
Range on HMM: 94-303/563.0
LMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYDFF-PKttGSFLYYGEMFVNVRKVEKMDEERSR-YTIEV--LPNGFS--NSVMMNVYVHT
.. | | .   . |||  ....   .||.  || .. .| | . ||     . ||.. |.  . |..    .|  .|.   | .. .  .  ..  |  |
iatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhyt

GWEPFGVPIRYANTTRSVVDVMNFVKSSNGseKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 |   |||   .     |.      |.  |   ..|  ..| ||.| .| | .    .....   . ...| ||.||.. |... ||  |.  ||  |. 
kWPdhgvPehslpvLifvkkssaankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

KITvpEGLQQKVEDLK
| |  | |...||.||
ket..ellaeqveelk
subfamily_egg_pd Subfamily egg 216-414 7.6e-08 26.4 In-house 86-280 (307) alignment 
Range on Protein: 216-414
Range on HMM: 86-280/307.0
LMGQIPKRGLEEEFWRAAYNEQVVMMYVLVG---SEDEKYdFFPKTTGSFLYY--GEMFVNVRKVEKMDEERSRYTIEVLpNGFSnsvMMNVYVhtgwEP
.. | | .   ..|||  ..|.|  . .|     ||  .| ..||.    | .  | . ..  ||..  .   | |   |  |       . ..    | 
ilaqaplkntvddfwrmvfqeevqyivmltsrkesercey.ywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd...deerfl....eh

FGVPIRYANTTRSVVDVMNFVKssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN--SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI
.   .....   | . |.  ..  | |.  .| ...|. .|. ....  |.. |         . . |. .| .|. .|||. .|  .|  .|....  |
wqgdvnnssdvysplrvlrklr..nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi

TVPEGL
   . |
gsakel
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 217-407 6.7e-10 33.2 In-house 94-284 (301) alignment 
Range on Protein: 217-407
Range on HMM: 94-284/301.0
MGQIPKRGLEEEFWRAA--YN-EQVVMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKM-DEERSRYTIEVLPN--GFSNSVMMnVYVHTGWE
  | | .   |.||     |. |..||.   |  . ||  ...| .... |  |   ..... |.. ... |. |.||      |.   ..  | .. | 
atqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvt.hyqysewt

PFGVPIRYANTtrsvVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
  |||  .|..     |.|..|| |.  . ..|   .| ||.  ||.       .. . .  . | .| .| .| |.|   .|   . |  .| . |.
drgvPkshael....fdlmelvkkse..kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 218-408 3.9e-35 115.1 In-house 123-313 (346) alignment 
Range on Protein: 218-408
Range on HMM: 123-313/346.0
GQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEKY---DFFPKTTGSFLYYGEMFVNVRKVEKMdEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVP
 |. .  . |.||   |.||. ..|..|  .  |     .|    | . | | ||.| |. .    .   |||||||.| |.||. .|. |. |  .  |
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvs.gdpkeytievlpegnsdsvicqvhhhapwkhlqqp

IRyantTRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI
 .    |  .. ..   .| .   .  . |||  |||||  ||    |   ||.  || | ||.|.|. ||| .|||. ||||.|  .. || .| 
pk....tlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 219-397 2.2e-10 35.2 In-house 51-232 (237) alignment 
Range on Protein: 219-397
Range on HMM: 51-232/237.0
QIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEK-YDFFPKTTgSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVP
| |     ..||.  ..|.   .||.  |. ....| ....|.|      || . | ..| |.. .   |  . .      .  ..  |  | |   |||
qgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvp

IRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLY
 . |   |   ...|  .  . |   ..    | ||.| |. . | .   ...    | . |..|  .||  ...  ||  ..
qqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 220-410 2.4e-07 24.5 In-house 98-294 (302) alignment 
Range on Protein: 220-410
Range on HMM: 98-294/302.0
IPKRGLEEEFWRAA--YNEQVVM-MYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKM-DE-----ERSRYTIEVLPNGFSNSVM--MNVYVHTG
.||.   | .|     ||  .|. .  .| .|..|. ... .  |  | .|.  |.  .|..  .|     .   ||.|.  .   . |   ... ....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WEPFGVPiryaNTTRSVVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFIT--LGAAFCCLNDNSEprIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
|   | |    . . . .|...| .|    ...||   .| ||.| ...   |  .|  .. ..  . .||. .|. |  || . .|   | ||.   . 
wpdhGap....keaytaldilkfcesyk..knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtd..llsivlpvrqcryGavqdeqqliylllcvtkglm

KKITV
.|..|
ekagv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 221-407 6.2e-18 59.7 In-house 72-267 (270) alignment 
Range on Protein: 221-407
Range on HMM: 72-267/270.0
PKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYT-IEVLPNGFSNSVMmnVYVHTGWEPFGVPI
|.    ..|||  ..|.|   ||.  |.    .|   ..|. ... . . .....|.....  || .. | ...  .| .. ..   . .. |   ||| 
PlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpr

RYA--NTTRSVVDVMNFVKSSNGSE----KLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.     .|.... ... |. |. .      |||   .| ||.| .|.|  |...|. ...  . .|....| .|.. |.  .||. ||  .. |....
eedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPRD_pd Subfamily PTPRD 223-422 1.1e-16 55.6 In-house 101-301 (564) alignment 
Range on Protein: 223-422
Range on HMM: 101-301/564.0
RGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYD-FFPKTtGsFLYYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPirya
    |.|||  ....   .||.  |. .. .|.. ..|.. |    |||. |.. . |.. .   | |...  .  |.| . . . .| |   |||    
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeir.tfklkkkkssesreVrqFhFtsWPdhgvp....

NTTRSVVDVMNFVKSSNGSEK--LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV--PEGL
....|..|... |...| ...  ..|   .| || | ||.. |    ....    | ..|||.|.||.  |.. .||. ..  .| ....  |    | |
esatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl

QQKVEDLK
.|... |.
kqhlqkLa
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 224-424 1.6e-13 45.4 In-house 100-302 (318) alignment 
Range on Protein: 224-424
Range on HMM: 100-302/318.0
GLEEEFWRAAYNEQvVMMYVLVGSE----DEKYDFFPKTTGSfLYYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYAN
   |.|||  .. .  .. |..  |     .| . .    ||   ||.. |....  ....   | ...|  .. ..| ..  | .| |   |||   |.
etieDfWrmvWeqn.savivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlr.efkvtrteeeesrqvrqyhytsWpdegvpesgas

TTRSVVDVMNfVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV--PEGLQQK
    | .| . .. ..| . ..|    | ||.| ||.. .    .....   . ..|| .|.||.  |   .||  .|  || ...   |    . |...
lldlvrqvsk.aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsr

VEDLKRG
...|.. 
irelreq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 227-407 1.8e-11 38.6 In-house 87-271 (274) alignment 
Range on Protein: 227-407
Range on HMM: 87-271/274.0
EEFWRAAYNEQV---VMMYVLVGSEDEK-YDFFPKTTGS--FLYYGEMFVNVRKVEKMDEersrYTIEVLPNGFS-NSVMMNVYVHTGWEPFGVPIRYAN
..|||  |.|.|   ||.  |  .. .|   .||....      ||.. ..|.|. . ..    |... |    . ..  .  | .| |    .| .  .
adfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekivernd....ysvrklvlkylerersvkhywytdWPdhksPddant

TTRSVVDVMNFVKSSNGS-EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
  . | .| .  ...|      .|    | ||.| ||.   |   |....   . .||  .| .|   |.. .||  ..  |  | |. 
lldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 227-401 2.6e-10 34.9 In-house 65-237 (239) alignment 
Range on Protein: 227-401
Range on HMM: 65-237/239.0
EEFWRAAYNEQVV---MMYVLV-GSEDEKYDFFPKTTGSflyYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiRYANTTR
 .|||  ..|. .   |.  |. | . . ....| .|     | .. | .|| | . .   | |. .   | ..   .  |  | |   ||| .|| .  
gdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...ycnlrvtlrktevfadyiir.tfvmsqvgqteeryvyqyhftvwpdkgvp.qyatavl

SVVDVMNfVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
 .   .    |  |.   ..    | ||.| |. . | .   . .    | . ||||| .||  |.. .||  ..|..|
glrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 227-401 2.9e-10 34.7 In-house 66-238 (239) alignment 
Range on Protein: 227-401
Range on HMM: 66-238/239.0
EEFWRAAYNEQVV---MMYVLV-GSEDEKYDFFPKTTGSflyYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiRYANTTR
 .|||  ..|. .   |.  |. | . . ....| .|     | .. | .|| | . .   | |. .   | ..   .  |  | |   ||| .|| .  
gdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...ycnlrvtlrktevfadyiir.tfvmsqvgqteeryvyqyhftvwpdkgvp.qyatavl

SVVDVMNfVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
 .   .    |  |.   ..    | ||.| |. . | .   . .    | . ||||| .||  |.. .||  ..|..|
glrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_PTPN6_pd Subfamily PTPN6 227-409 1.3e-09 32.4 In-house 112-302 (306) alignment 
Range on Protein: 227-409
Range on HMM: 112-302/306.0
EEFWRAAYNEQVVMMyVLVGSEDEK-----YDFFPKTTGSFLyYGEMFVNVRKVEKMDEERSRyTIEVLP-NGFSNSVMMNVYVHTGWEPFGVPIRYANT
..||| ...|.  .. |..  | |.     . ..|... .   ||.. |.  . .....   | .. |   .  ...  .  | .. |   |||      
sdFWrmvwqensrvi.vmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilR.elsvskkkkkkeerevfqyhfksWPdhgvpkdpgav

TRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN---SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKIT
   . || .  ....   .  ..|   .| || | || . .    .. .    .  | ..|| .|.||   |   .||  .|  . .||..| .
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk
0046846 (Phosphotyrosine protein) phosphatases II 263-406 7.4e-11 37.6 In-house 77-175 (176) alignment 
Range on Protein: 263-406
Range on HMM: 77-175/176.0
LyygemfvnvrkvekmdeersrytievlpngfsnsvmmnVYVHTGWEPFGVPIRyaNTTRSVVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFITlgaafC
.                                       | |..|. .|||    .   .... .. . ...  .. ||  . |.||.| ..      .
i......................................qylhlpwpDhgvpdl..elllellefirealkeg..gpvlVHCsaGigRtgtlva.....a

CLND-NSEPRIGEIVKAIRSQRP-NAVESIKQYASLYLCLLYYIKK
 |   .    . |... .|.||| .||.. .||  || ..|...||
yllelekglsveealalvreqRplgavqtpeQyrflyefellllkk
0048076 (Phosphotyrosine protein) phosphatases II 263-403 1.9e-10 36.1 In-house 11-142 (145) alignment 
Range on Protein: 263-403
Range on HMM: 11-142/145.0
LYYGEMFvNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSS---NgsEKLLVVSKNGCGRAGFFItlgA
||.| .  .....| . .   .. . . ..    . .   |....|. .|||    . .. . ....|...    .  .. ||  . |.||.|...   |
lylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvp....dllellleflefieealkeg..gpvlVHCsaGvgRtgtlv...a

AFCCLNDNsePRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY
|...|  .    . |... .|||||.||..  |.  ||...|..
aylmlllg..vsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 263-398 1.2e-09 33.5 In-house 11-139 (144) alignment 
Range on Protein: 263-398
Range on HMM: 11-139/144.0
LYYGEMFvNVRKVEKMDEERSRYTIEVLPNGFSNSVMMN--VYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSS-NGSEKLLVVSKNGCGRAGFFItlgA
||.| .   ....| . .   .. | . ..   ...  .   |.|..|. .|||    . .  . ....|...  . ... ||  . |.||.|...   |
lylgslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvp....dllellleflefieealeeggpvlVHCsaGvgRtgtlv...a

AFCCLNDNsePRIGEIVKAIRSQRPNAVESIKQYASLYL
|. ..  .    . |... .||.||.||..  |.  |..
aylmkklg..lsleealalvrsrrpgavpnpgqlrfLle
0049772 (Phosphotyrosine protein) phosphatases II 264-415 1.2e-10 37.1 In-house 167-291 (314) alignment 
Range on Protein: 264-415
Range on HMM: 167-291/314.0
YygemfvnvrkvekmdeersrytiEVL--PNGFSNSVmmNVYVHTGWEPFGVPiryanTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITlgAAF
                        |.|  |. |.. .    |... .. ...|     ... . ....|... .  ...||  | |.||.| |..  ||.
k.......................eelydpelferlg..ikylripvpDgsap.....lledfdeflefieeadkggpvlvHCkaGkgRtgtfvv..aay

CCLNDnSEpRIGEIVKAIRSQRP-----NAVESIKQYASLYLCLLYYIKKKITVPEGLQ
...       . |... .|..||     ...|. .||   . .||.|.|......| |.
lmkll.gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkfyeyle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 292-401 2.6e-07 24.4 In-house 84-191 (440) alignment 
Range on Protein: 292-401
Range on HMM: 84-191/440.0
NGFsNSVMMNVYVHTGWEPFGVPiRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIK
||  .|  .. | . ||   ||| ..|     ... .|  .   |.  ||| .  |.||.|  |.. . .   . . .  |  .....|..||. |.. .
ngi.esrtlkqyhyqgwpdkgvp.kfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYASLYLCLL
||| .. ..|
qyafvheavl
PTPc_DSPc_SM00012 300-402 4.9e-19 63.9 In-house 2-105 (105) alignment 
Range on Protein: 300-402
Range on HMM: 2-105/105.0
MNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN-SEPRIGEIVKAIRSQRPNAVESIKQYASLYL
...| .|||  .||| .  . .. . .|... . |. |. ..|....|.||.| |..|  . . |... .|. | .|||..|.|||..|..  ||  || 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLLY
.||.
alle
subfamily_CG42327_pd Subfamily CG42327 339-406 6.4e-06 20.0 In-house 249-317 (319) alignment 
Range on Protein: 339-406
Range on HMM: 249-317/319.0
KLLVVSKNGCGRAGFFITLGAAFCCLNDN-SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 | |   .| ||.|  |.   |.  |...     | ..|  .| .| .|| ...||. .|  |  | ||
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk