Gene Y69A2AR.19 in Caenorhabditis elegans

Synonym: CELE_Y69A2AR.19, CELE_Y69A2AR.19

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP226_AA protein Get Run
CeleP226_AA_1003-1255 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
WSN Domain of unknown function 169-234 1.4e-23 72.6 Pfam-A 2-67 (69) alignment 
Range on Protein: 169-234
Range on HMM: 2-67/69.0
KSADYLNHTTLIAHIANGIALQAGLMKGSIPIDAAVSELLNFGSVKVSDITAFKPDQITALIGKLK
. ...|.. . ||...|||.|||||..|||||| ...||||.||...|.......|.. . . ||.
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls
DUF4231 Protein of unknown function (DUF4231) 930-987 2.8e-07 17.0 Pfam-A 47-106 (112) alignment 
Range on Protein: 930-987
Range on HMM: 47-106/112.0
SGISITLIIIIVGSILALIGVAVGIY-FGVRWYEKKKAAEQMEHEIVVWV-KAQAYKSLE
..   ...  |.....|.. . .... .. ||......||....| . .  .|. |.. .
gsnwlkwvtvilsalvailaslatffklkerwrryrataEslkaekwqflaragpysdeq
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 973-1272 1e-141 466.1 In-house 5-300 (301) alignment 
Range on Protein: 973-1272
Range on HMM: 5-300/301.0
EIVVWVKAQAYKSLEAAIIVLVASLHVVWGTQTS-VSVEKSNAYLPKEKNRRPLAtPCNPETAVEVMSDGTRIPIHANWINTSpdvdGNTQKFIATQGPL
.| .|.... .|  . .     .... |  |  .   ...|.|||||.|.|.| . ||.|.|||||..||.|.|||||||.||    |....||||||||
kiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptv.PckPstavevivdGkrvPihanwipts....GhphrfiatqgPl

PNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQG
.|||.|||.|.....||..|||.|.|||.||||.||.||.... .|..|.|.|....|.|| ...||||..|||....|.|||.|||||..|.|.|.|..
kntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPks

HAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNIDMKHYKEQFEML
||..||||...|.|.|||||||||||||.|.||.|.|....|.|..|..|..|...||..||...||..|.||...|.||||.||...|||.|.||..|.
haelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeqlamf

D
|
d
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 980-1258 2.1e-45 150.1 In-house 5-283 (307) alignment 
Range on Protein: 980-1258
Range on HMM: 5-283/307.0
AQAYKSLEAAIIVLVASLHVVWGTQTS-VSVEKSNAYlpKEKNRRpLATPCNPETAVEVMSDGTRI-PIHANWINTSpdvdGNTQKFIATQGPLPNTSDD
    ..|.  .  ||  ..|.   .   |.||  .|    .|||     .|   . . |  ||     ||||.. ..     . .|||..|||| ||  .
pwvqrtldkgvqalvdefrvlakktpegvtveafsan..tdknry.qdvkcqdkgrivvkfdglasdyihanylgia....ikpkkficaqgplentqys

FWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDL-ERYKLKTVTQEQILGDSTSKRTIQVEDTSKEF--PTRTITHYQYHSWPDQGIPQGHAQ
||.|.  .|||.|.|||. .|  . ||..|.|.  ||     |. .  .|..  .   .  .  |.| .   ..   .|||.|.|.. |||.|.||    
fwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt

CFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANR-TLVLNQAVAELRDQRWCAIQTVEQ-MYWVQVGSVYRLSKEKN
. .|..  .  . |.|||||||.||. . .|  ..   ..|      ... | |||.||  ||||  | .|  .|   | | . |.
ainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 998-1242 2.6e-40 133.5 In-house 29-272 (305) alignment 
Range on Protein: 998-1242
Range on HMM: 29-272/305.0
HVVWGTQTSVSVEKSNAYLPKEKNRRPLATPCNPetaVEVMSDGTRIpiHANWINTSPdVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQ
. .  ...|. |.|..|   |.... .   . .    . .  . .    ....|| |  |||  . .|.|..||||.|| .||| ..   ||.|.|||..
kslyeeeesidvgkkeankaknrlkeitlldddr...iiltekesld..dsdyinasy.vdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

FVEKEEEKCHEYFPVRTGQIVDLERYKLKtVTQEQILGDSTsKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLM----NMAKESKK-PIV
 || ...||. |.| .... ......... ...|.   | . .| ...   ...  .||...||  .|||.|.||  .   .|.    .  |..|. |..
lveggkdkCrqYWpesktekkefgefsve.lksektasdyi.eRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQM
||||||.|||  ||| .     . .  .. . . . .|| .|  ..|| .| 
VhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqY
0050432 (Phosphotyrosine protein) phosphatases II 1004-1245 1.9e-63 210.0 In-house 55-291 (308) alignment 
Range on Protein: 1004-1245
Range on HMM: 55-291/308.0
QTSVSVEKSNAYLPKEKNRRPLaTPCNPETAVEVmsDGTRIPIHANWINTSPdvDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEK
... . . ..    |.||| .   ...  . | .  |..   |.|.....     ....|||||||||||| .||| ||  ..|...|||...||.. ||
kplleysvallpenkdkNrykd.ilpydhsRVkl..degsdYInAsyvdgys..sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrek

CHEYFPVRTG-QIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES--KKPIVVHCSAGIGRT
|..|.|  .| ...  ........ .|.   |.  .||......... ..||.||..|..|||.|.|.  ....|.......|  ..|||||||||.|||
caqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
  |||  .. . . ..... . .||. || ||....||.||....
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1005-1245 2.9e-41 136.6 In-house 36-275 (319) alignment 
Range on Protein: 1005-1245
Range on HMM: 36-275/319.0
TSVSVEKSNAYLPKEKNRRPLATPCNpETAVEVMS-DGTR--IPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEE
.........    |.||| .   ...  | | ... ||.     | |..|..      . .||||||.|| || .||| ||  ... .||||.. ||| .
vndtfdsaskeenkkknryqnilayd.rtrvvlseldgvegsdyinasfidgy....qerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

EKCHEYFPVRtgQIVDLERYKLKTVTQEQIlgDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAG
 |...|.|    ....  |. ..   .|.   .   .| ....  | |  ||...|.|| .|||...|.   .  ||..  ..     ...|||||||||
vklkkywpee..nfeeyGrlivtleeeeel..edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

IGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
.||| .||. . .   |  . .| . . | .|| || . .|. ||  ..
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi
subfamily_PTPRG_pd Subfamily PTPRG 1005-1260 8.5e-35 115.0 In-house 35-295 (563) alignment 
Range on Protein: 1005-1260
Range on HMM: 35-295/563.0
TSVSVEKSNAYLPKEKNRRPLATPCNpETAVEVMSDgTRIPIHANWINTSpDVDGN--TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEE
... .|.|..   |.|||    .. . .. |.. .  . .  . ..|| .  .||   ...||||||||..| |||| |.  ..|...||. ..||.. .
kdldaehsqkpenkrKnRylnivayd.rsRvklspl.pgkkkklDYinAn.yidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrr

KCHEYFPVrtGQIVDLERYKLKTVTQEQILgdSTSKRTIQVED-----TSKEFPTRTITHYQYHSWPDQGIPQghAQCFDLMNMAKESK------KPIVV
||. |.|    . ....  ... ...|..   . ..||.....     ...    .....|.| .|||.| |.   . ..|... |.|.       ||||
kcdvYWPk..desetygalqvtlieeevla..lytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe..hslpvLifvkkssaankaeaGPivv

HCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYR-LSKEKNID
|||||.|||  .|. . .   . .. .  . . .  .| ||   .|| || ...    .   .|||... 
HcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1005-1243 2.1e-23 77.5 In-house 32-283 (301) alignment 
Range on Protein: 1005-1243
Range on HMM: 32-283/301.0
TSVSVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDgtripIHANWINTSpDVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEE
..|.....|..| . ||  ..       .  . ..       . ..||.|  .||  ...||||.|||. .|  ||| ..  .|. ..||...  |. ..
ctvglseenkalnrfknitvyddnriilkpkpnldl.....cqreyinas.yidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtks

KCHEYFPVRTGQIVDLERYKLkTVTQEQILGDST-------------SKRTIQVEDTSKEFPTRTITHYQYHSWPDQGI---PQGHAQCFD--LMNMAKE
||..|.|  . .  .    .  |...||.. | .              .....  ...... ..... .|  .||..|.   |.   |  |  ..   | 
kceqywpnseaeseefgpftv.tlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki

SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
.. |.|||||....|.  ... .     . |.    . | .  .| ..  |..| ||  
gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyt
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1006-1170 5.1e-19 63.2 In-house 24-181 (297) alignment 
Range on Protein: 1006-1170
Range on HMM: 24-181/297.0
SVSVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDgtRIPIHANWInTSPDVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCH
| |. | |. | |.. |  |||  .      |...  |  | |... . || . .  |.| .|||| .| |||||.|  . | ..||.... |   .|| 
sfssakrnsslrknryrdilatddtrvkllrvite..rdyinadyv.vfpdee.adlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

EYFPVrtgqiVDLERYKLKTVTQEQILGDSTSKRTIQVEDTSK--EFPTRTITHYQYHSWPDQGIPQ
 |.|      |. || |   |  | .   |    .... .        .| ..| |. |||| |.| 
pywps.....vvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
0045450 (Phosphotyrosine protein) phosphatases II 1007-1246 2.2e-62 206.9 In-house 45-297 (307) alignment 
Range on Protein: 1007-1246
Range on HMM: 45-297/307.0
VSVEKSNAYLPKEKNRRPLaTPCNPETAVEVMSDGTRIP----IHANWINTSP----DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVE
 . . .. .  |.||| .   .... | | ..| . ...    |.|..... .    |.  ...||||||||||.| .||| |.. ..|...|||...||
geysiallpenkdknrykd.ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

KEEEKCHEYFPVRtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVH
.. |||..|.|   |. .  .... ...  |.   |.   ||. |.|.......||.||..|..|||.|.|.  ....|.......      ...|..||
lgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVH

CSAGIGRTVSFIATQYIPSAVLANRT---LVLNQAVAELRDQRWCAIQTVEQMYWVQ
||||.||| .|||  .. . . .. |   . | .||..||.||..|.|. ||.....
CsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
0040438 (Phosphotyrosine protein) phosphatases II 1008-1248 9.1e-65 214.3 In-house 34-271 (317) alignment 
Range on Protein: 1008-1248
Range on HMM: 34-271/317.0
SVEKSNAYLPKEKNRRPLaTPCNPETAVEVMSDGTRIP---IHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKC
. . .. .  |.||| |   .... . | . ..| . .   |.|...    |.   ..|||||||||||| .||| ||. ..|...|||....|.. |||
tysvaelpenkdknrypd.ilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

HEYFPVrtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGRT
..|.|   |. .  .... ...  |.   ..   ||..|||. .. ..||.||..|..|||.|.|. . ...|......|.    ..|..||||||.|||
aqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVG
 .|||  .. . .  .... . .||.||| ||..|.|| ||....   
GtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
DSPc_SM00195 1008-1243 1.3e-58 193.8 In-house 17-252 (263) alignment 
Range on Protein: 1008-1243
Range on HMM: 17-252/263.0
SVEKSNAYLPKEKNRRPlATPCNPETAVEVMSDG---TRIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKC
......    |.|||     ... .| |.. ..    .   |.||.|...     ...|.||||||||.| .|||.||  .||...|||....|...|||
etteaekkknksknRyk.nilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

HEYFPVRTGQIVDLERYKLKTVTQEQILgDSTSKRTIQVEDTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKK----PIVVHCSAGIGRT
..|.|   |.  . .....|.| .|.   |.. .||.... . |   ||..|.|||..|||.|.|. . ....|....|.||.    |||||||||.|||
drywpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
 .|.....| | . .. .. . . | |||.||  ..|| ||  
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYl
PTPc_SM00194 1008-1243 1.3e-58 193.8 In-house 17-252 (263) alignment 
Range on Protein: 1008-1243
Range on HMM: 17-252/263.0
SVEKSNAYLPKEKNRRPlATPCNPETAVEVMSDG---TRIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKC
......    |.|||     ... .| |.. ..    .   |.||.|...     ...|.||||||||.| .|||.||  .||...|||....|...|||
etteaekkknksknRyk.nilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

HEYFPVRTGQIVDLERYKLKTVTQEQILgDSTSKRTIQVEDTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKK----PIVVHCSAGIGRT
..|.|   |.  . .....|.| .|.   |.. .||.... . |   ||..|.|||..|||.|.|. . ....|....|.||.    |||||||||.|||
drywpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
 .|.....| | . .. .. . . | |||.||  ..|| ||  
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1008-1245 1.3e-44 147.4 In-house 38-271 (288) alignment 
Range on Protein: 1008-1245
Range on HMM: 38-271/288.0
SVEKSNAYLPKEKNRRPLATPCNpETAVEVMSdGTRIpIHANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHE
||....    ..||| .   | . |..|..   .      |..|| |  |......|.|||||||..| .||| .|  .|..|.||| ..||....||.|
svtagrlavnakknRyrnilpyD.ekrvklkk.leee.agaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCee

YFPVRTgQIVDLERYKLKTVTQEQIlgDSTSKRTIQVEdtsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNM---AKESK-KPIVVHCSAGIGRTVS
|.|    . .     ... | ...   ... .|.. .|   |.   ..||.||| .|||.|.|. .|. ..|...   |.... .||.||||||.|||  
YWPdad.kpknyGsvtvtlveskel..edfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgt

FIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
||| . .  || .. .. .  .||.|| ||   .||..|  ..
FialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi
subfamily_PTPRA_pd Subfamily PTPRA 1008-1264 1.4e-39 130.9 In-house 49-307 (330) alignment 
Range on Protein: 1008-1264
Range on HMM: 49-307/330.0
SVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDGTRipiHANWINTSPdVDGNTQ--KFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCH
..| ..    ||||| .   | . .  .  . .|.    ....||.|  .||  .  ||||.|||. .| .||| |.  .|  |.||| .. |..||||.
tlelaskeenkeknrvvnilPydfsrvilsvkeGve...esdyinasf.idGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca

EYFPVRtGqIVDLERYKLKtVTQEQILGDST-SKRTIQ-VEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGR
 |.|   | .|     ... | .|..| | |  |  .| . |...| ..| .. . ..|||| |.|      ..|..  |.       |||||||||.||
qywPde.G.lvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

TVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV-QVGSVYRLSKEKNIDMKHY
| .||. . .   | |.| . . ..| .|| ||   .|| ||  .. .|   | |  . ..|.   
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssl
0039614 (Phosphotyrosine protein) phosphatases II 1009-1246 3.8e-58 192.6 In-house 48-282 (297) alignment 
Range on Protein: 1009-1246
Range on HMM: 48-282/297.0
VEKSNAYLPKEKNRRPLaTPCNPETAVEVMS-DGT---RIPIHANWIntspDVDGN-TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEeK
 . .. .  |.||| .   .... . | . . ||.      |.|...    |.    |.||||||||||.| .||| ||. ..|...|||...||..  |
ysiallpenkdknrykd.ilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.k

CHEYFPVRTGqivDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEfptRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGI
|..|.| ..|     .... .... |.   |    ||. |......   ||.||.||..||| |.|. ............|      ...|..||||||.
caqywpeegg...tygdftvtllkveh..ldgytvrtlevtnnges...rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGv

GRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
||| .|||  .. . .  .... . .||.||| ||..|.|| .|.....
gRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly
0043336 (Phosphotyrosine protein) phosphatases II 1009-1245 2.8e-57 189.7 In-house 37-269 (278) alignment 
Range on Protein: 1009-1245
Range on HMM: 37-269/278.0
VEKSNAYLPKEKNRRPLaTPCNPETAVEVMSDGTRIP---IHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCH
 . .. .  |.||| .   .... . | . ..| . .   |.|...    |.   ..||||||||||.| .||| ||. ..|.|.|||...||.. .||.
ysiallpenkdknrykd.ilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkca

EYFPvrtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPtRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTV
.|.|   |. .  .... ... .|.   |    ||. |... . .. ||.|||.|..|||.|.|   .. .|......|    |..|..||||||.||| 
qYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTG

SFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 |||  .. . .  .... | .||.||| ||..|.|| .|....
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 1010-1245 1e-59 197.8 In-house 42-278 (288) alignment 
Range on Protein: 1010-1245
Range on HMM: 42-278/288.0
EKSNAYLPKEKNRRpLATPCNPETAVEVMSDGT---RIPIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHE
  ..    .||||     ...  . | . . .       |.|..|    |.  ...|||||||||||| .||| ||  ..|...|||...||.. |||. 
saallpenleknRy.sdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YFPVrtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTS---KEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGR
|.|   |. . ..... ...  |.   |.  .||..|....   ..  .||.||..|..|||.|.|.   ...|........    ..|.|||||||.||
Ywpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgR

TVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
|  |||  .. . ....... . .||. || ||....||.||...|
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
0047943 (Phosphotyrosine protein) phosphatases II 1012-1245 1e-61 204.1 In-house 33-264 (273) alignment 
Range on Protein: 1012-1245
Range on HMM: 33-264/273.0
SNAYLPKEKNRRPLaTPCNPETAVEVmSDGTRIPIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVR
..    |.||| .   ...  . | . .||.   |.|...    |.   ..|||||||||||| .||| ||  ..|...|||...||.. |||. |.|  
allpenkdknrykd.ilpydhsrvkl.gdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

TGQ-IVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGIGRTVSFI
 |.  .  .... ... .|.   |.  .||....... .  .||.||..|..|||.|.|.  ............      |..|.|||||||.||| .||
ggelsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

ATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
|  .. . . ..... . .||. ||.||....||.||....
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1014-1247 1.5e-36 120.9 In-house 39-266 (288) alignment 
Range on Protein: 1014-1247
Range on HMM: 39-266/288.0
AYLPKEKNRRPLATPCNPETAVEvMSDGTRIPIHANWINtspdVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTG
... .  . |    |.   | |  .|| .   |.|| .        . ...| .| ||  | . .| |.    || .||||...||  ||  ||||.. |
sfianptrdryenlprcditrvk.lsddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

QIVDLERYklKTVTQEQIlgdSTSKRTIQV--EDTSKEFPTRT-ITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIP
. . . |.   ||....    .  .....|     |||  ..  . .  .. |.|.|.|. .   . |... |. .||||||.|||.|||  .| .  . 
ekarigrl..ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililial

SAVLANRTLVLNQAVAELRDQRWCAIQTVEQ-MYWVQV
 ..  .  | ... .|.||..|  ||||  | .|  ..
eslrlddflgirsllaklreerfkaiqtemqylyvhrc
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1014-1145 2.2e-15 51.2 In-house 55-184 (350) alignment 
Range on Protein: 1014-1145
Range on HMM: 55-184/350.0
AYLPKEKNRRPLATPCNPETAVEVMSDGTRiPIHANWINTS-PDVDGNTQ-KFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVR
  || |..|  |    ..  |..    .    | ||... . . |. |.. |.||||.|||.| |||....   ||. ...| . || . |||..|..  
nilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg

TgqiVDLERYKLKTVTQEQILGDSTSKRTIQVED
.   .|    ||.   .. .  . .|... .|. 
s...ydditvklaskwenimgindsslysadvkk
0040439 (Phosphotyrosine protein) phosphatases II 1015-1246 3.1e-56 186.1 In-house 9-239 (249) alignment 
Range on Protein: 1015-1246
Range on HMM: 9-239/249.0
YLPKEKNRRPLaTPCNPETAVEVMSDGTRIP---IHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVr
.  |.||| |   .... . | . . . . .   |.|..|    |.   ...|||||||||.| .||| |.. ......|||...||.. |||..|.|  
penkdknrypd.ilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

tGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGIGRTVSFIA
 |. .  .... ...  |.   |.   ||...... .. ..||..|.||..|||.|.|.  ....|.......      ...|..||||||.|||  |||
.ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

TQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
  .. . .  .... | .||..||.||..|.|. ||.....
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfly
0045098 (Phosphotyrosine protein) phosphatases II 1015-1245 2.2e-54 180.1 In-house 30-264 (278) alignment 
Range on Protein: 1015-1245
Range on HMM: 30-264/278.0
YLPKEKNRRPLATPCNPETAVEvmsDgtriPIHANWINTSpdvdgNtQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRtGQ
||   .  |    .... . |    |     |.|..|..      . .||||||||||.| .||| |.. ......|||...||.. |||..|.|   |.
ylgnldknRykdilpydhsrVk...d....YINAsyidgy.....p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e.gg

IVDLERYKLKTVTQEQIlgDSTSKRTIQVEDT---SKEFPTRTITHYQYHSWPDQGIPQGH--AQCFDLMNMAKE-----------------SKKPIVVH
 .  ........  |..  |   .||. |...    .....|..||..|..||| |.|  .  .. ..|... .|                 |..|..||
sltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGIGRTVSFIATQYIPSAVlaNRTLVLNQAVAELRDQRWC-AIQTVEQMYWV
||||.|||  ..|  .. . .  .... | .||.||| ||.. |.|. ||....
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl
subfamily_PTPN6_pd Subfamily PTPN6 1015-1245 1e-37 124.8 In-house 52-289 (306) alignment 
Range on Protein: 1015-1245
Range on HMM: 52-289/306.0
YLPKEKNRRPLATPCnPETAVEVMSDGTRI--PIHANWINtsPDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRT
   |||||     |   .| | . ....     | || |.   .| |.....||||| |..|  ||| ||   . . .||. . ||. .|||  |.|  .
penkeknryknilPf.Dhtrvilkepsvpgsdyinanyik..kevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee

GQIVdLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMN---MAKES-K----KPIVVHCSAGIGRTVSFI
 .     ......|....   ..   |...|. ..|.  .|.. .|...||||.|.|.   .  |...   . .|. .     ||||||||||||| .||
ekee.yGkisvtnvseks..ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

ATQYIPSAVLANRTL---VLNQAVAELRDQRWCAIQTVEQMYWV
 .  . . .  . .     ....|  .|.||   .|| .|  .|
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfv
0046845 (Phosphotyrosine protein) phosphatases II 1016-1245 3.1e-60 199.3 In-house 27-266 (284) alignment 
Range on Protein: 1016-1245
Range on HMM: 27-266/284.0
LPKEKNRRPLaTPCNPETAVEVMSDGT----RIPIHANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPV
  ..||| .   ...  . | . | .        |.|.....   |.  ...|||||||||||| .||| ||  ..|...|||...||.. |||. |.| 
enlsknRykd.ilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

RtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES------KKPIVVHCSAGIGRTVSFI
  |. . ..... ...  |.   |.  .||....... . ..||.||..|.||||.|.|.  .. ........|.      ..|||||||||.|||  ||
e.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

ATQYIPSAVLANR---TLVLNQAVAELRDQRWCAIQTVEQMYWV
|  .. . . ...   .. . .||. ||.||....||.||...|
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1016-1257 7.2e-40 131.5 In-house 54-294 (305) alignment 
Range on Protein: 1016-1257
Range on HMM: 54-294/305.0
LPKEKNRRpLATPCNPETAVEVMSDGTRIPIHANWINtSPDVDgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQI
. . |||     ||. ..|| .        ||||..   | .    ..||..|||| .| |.|| ||  .||| .||||. ||    || .|.|.  |. 
iaitknry.qdvpcqdqsavkldkpspsdyihanyvg.cpmip..ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

VDLERyklkTVTQEQILGDSTSKRT--IQVEDTSKEF---PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIP
..|       .  |.. |    .|   ||.      .    . .. | |.  |||.|.|  .   ..|.   . || ||||||||||||| . .| .|| 
lelks....givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyil

SAVLANRTL-VLNQAVAELRDQRWCAIQTVEQMYW-VQVGSVYRLSKEK
  .  |.    . . |  |||||  .||.  |  .  .|   | | | |
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1016-1267 1.4e-30 101.5 In-house 16-273 (290) alignment 
Range on Protein: 1016-1267
Range on HMM: 16-273/290.0
LPKEKNRRPLATPCNPETAVEVMSDGTRIP---IHANWINTSpdvdgNTQKFIATQGPLPNT-------SDDFWTMVQFHKVETVVMLCQFVEKEEE---
. |..  . |. |   .| |     |.|.    |||| .  .     | ...|.|| |. ..         .|| |..  ||. |||||.| ||...   
vkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcp.....nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

-KCHEYFPVRTGQIVDLERYKLKTvtQEQILGDSTSKRTIQVE-DTSKEFptrTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRT
  | .|.| . |... ..  ..|   ....  |   .|.. |. |  .||   |.||.....| .  ... .    .|... | || |..|||  || | 
faCakYvpesvgeelkfkgltvkC..kskekeddvetRelvvkfddeeef...tvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrs

VSFIATQYIPSAVL-ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNIDMKHYKEQ
  . | .     .   .  ..|.... .|| ||  ||.. ... .|  | | .. ....  .....|.
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetek
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1016-1109 1.2e-09 31.9 In-house 58-154 (349) alignment 
Range on Protein: 1016-1109
Range on HMM: 58-154/349.0
LPKEKNRRPLATPCNPETAVEVMSDGTRIPIHANWINTS----PDVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFP
|| |  |  |    ..  ...     .   .  ..||.     . ..   .|.|||| ||| | |||....   .|. |. | .  |.. |||. |. 
lPyehsrvklkkslksskvikastsesdsgklddyinanylkltris.vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
0036941 (Phosphotyrosine protein) phosphatases II 1017-1269 2.7e-66 219.2 In-house 39-292 (297) alignment 
Range on Protein: 1017-1269
Range on HMM: 39-292/297.0
PKEKNRRPLaTPCNPETAVEVmSDGTRIPIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIV
 .|||| .   .... | | . .|.    |.|...    |. . ..|||||||||||| .||| ||  ..|...|||...||.. |||..|.|  .|. .
nleknRykd.ilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesl

DLERYKLKTVTQEQILGDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGIGRTVSFIATQYIP
  ......... |..| |.   ||..|.|| .. ..||.||..|..||| |.|. .|...|.......      |..|..||||||.||. .|||  .. 
tygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml

SAVL---ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVqVGSVYRLSKEKNIDMKHYKEQFE
. .     .... . .|| .||.||..|.||.||....    .. | | |.... ..|. ..
qqledklkeggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepllklvll
subfamily_PTPN13_pd Subfamily PTPN13 1017-1247 3.6e-45 149.4 In-house 37-263 (273) alignment 
Range on Protein: 1017-1247
Range on HMM: 37-263/273.0
PKEKNRRPLATPCNpETAVEVMSDGTriPIHANWINTSpdVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIV
 |.|||     |.. || |.. ..|.   | |..|.    |. .. ..||.|||||.| .||| ||   |.| ..|. . .||.. ||| |.|..... .
nkdknryrnvlPyd.etrvklgdegg..yinaslikvp..vgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

DLE-RYKLKTVTQEQIlgDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMN---MAKESKKPIVVHCSAGIGRTVSFIATQYIPSA
 .. |.... . ...   |. . |...|.|.  .  .| ..| .. .||| |.|.  |.   ..      .... ||||||||||||. ..|. . .   
kvsnrlevellkvqkl..dgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlgl

VLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQV
.  .. . ... | .||.||   .|| .|  .|  
ierdkefdvkeivrklreqrqgvvqtkdqyifvyk
0042113 (Phosphotyrosine protein) phosphatases II 1018-1246 8.9e-56 184.4 In-house 10-236 (245) alignment 
Range on Protein: 1018-1246
Range on HMM: 10-236/245.0
KEKNRRPlATPCNPETAVEVMSDGTRI---PIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVrtGQ
|.||| .   .... | | ...||..    .|.|...    |..  |.||||||||||.| .||| |.. ....|.|||....|.. .||..|.|   |.
kdknrys.dilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

IVDLERYKLKTVTQEQilGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYI
..  .... .... |.   |.   ||..|... .....|...||.|..|||.|.|  ... .|.......     |..|..||||||.|||  |||  ..
sltygdftvtllseeh..lddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

PSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
 . . ..... | .||.|||.||..|.|| .|.....
leqlekelgvsleeavkelrsqRpgavqtpsqyrfly
0037934 (Phosphotyrosine protein) phosphatases II 1018-1246 8.5e-51 168.2 In-house 11-235 (243) alignment 
Range on Protein: 1018-1246
Range on HMM: 11-235/243.0
KEKNRRPLaTPCNPETAVEVmsDGtRIPIHANWINTSPdvdgntqKFIATQGPLPNTSDD----FWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvrtG
..||| .   .... . | .  .|    |.||.|.  |       ..||||||||.| .|    || |.. ......|||...||.. |||..|.|   |
lsknrysd.ilpydhsrvkl..eg.sdyinanliyvtp.......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...g

QIvDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK------------ESKKPIVVHCSAGIGRTV
..   .... ... .|.  .|.   ||...| .. . .||...||.|..|||.|.|. .... |......             |..|..||||||.||| 
ev.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

SFIATQYIPSAVlanrTLVLNQAVAELRDQRWC-AIQTVEQMYWVQ
 .||  .. . .    .. | .||..||.||.. |.|| .|.....
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfly
Y_phosphatase Protein-tyrosine phosphatase 1019-1245 7.6e-57 187.8 Pfam-A 3-229 (235) alignment 
Range on Protein: 1019-1245
Range on HMM: 3-229/235.0
EKNRRPlATPCNPETAVEV-MSDGTRIPIHANWINTSPDvdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVD
.||| .   ..  .| |..  |.|.   |.||.... ..    ..|||||||||..| .||| ||  .||...|||.. .||..|||..|.| .... . 
kknRyk.dilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

LERYKLKTVTQEQILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAV
 ...|......|.   ...  |....... .|  .|......|..|||.|.|.   . .||... ..||    .|.|||||||.||| .|.| ... . .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 |.... . |.| ||| ||  ..|..|| ...
eaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 1019-1245 7.6e-57 187.8 In-house 3-229 (235) alignment 
Range on Protein: 1019-1245
Range on HMM: 3-229/235.0
EKNRRPlATPCNPETAVEV-MSDGTRIPIHANWINTSPDvdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVD
.||| .   ..  .| |..  |.|.   |.||.... ..    ..|||||||||..| .||| ||  .||...|||.. .||..|||..|.| .... . 
kknRyk.dilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

LERYKLKTVTQEQILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAV
 ...|......|.   ...  |....... .|  .|......|..|||.|.|.   . .||... ..||    .|.|||||||.||| .|.| ... . .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 |.... . |.| ||| ||  ..|..|| ...
eaeeevdvlqivkelRkqRpgmvqsleqYifl
subfamily_PTPN3_pd Subfamily PTPN3 1019-1255 4.9e-44 145.3 In-house 43-276 (280) alignment 
Range on Protein: 1019-1255
Range on HMM: 43-276/280.0
EKNRRPLATPCNpETAVEVMSDGTrIPIHANWINTSPDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVrTGQIVDL
.|||    .| . .| |.. .  |   | ||..|   .  |  ...|||||||..|. |||.||. .|....||| . ||.   |||.|.|  |.. ...
sknryrdilpyd.atrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeley

ERYKLKTVTQEQilGDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAVL
 ....|   ...    |   | . ..|....   |.|.. || .|||.|.|. .|. .....  .. .    .|.|||||||||||  .|. .   . . 
gefsvkcekede..tksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalie

ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVqVGSVYRLSK
|.. .   . | ..|||| . .||..|  .|   .. ....
aaepvypldivrtmrdqramlvqtasqykfv.Ceailkvye
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1019-1245 4.2e-41 135.8 In-house 30-260 (274) alignment 
Range on Protein: 1019-1245
Range on HMM: 30-260/274.0
EKNRRPLATPcNPETAVEVMSDG----TRIPIHANWINTspdVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQ
.|||     | |... | . |.         | ||.|      |.... ..||||||||| .||| |.  ..|. .||| .. |..|.||..||| ... 
tknryktilP.nensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

IVDlERYKLKTVTQ-EQILGDSTSKRTIQVEDTSKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK-------KPIVVHCSAGIGRTVSFIAT
 .. |||.   ..  . .  .  | |.. .. ...   .|...|| | .|||.  |.   . .||..  .||.        |.|||||||||||  |||.
eis.erygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

QYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
.     . .. .. . . |..|| .|   .|| ||  ..
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli
subfamily_CG7180_pd Subfamily CG7180 1019-1244 2.8e-22 73.7 In-house 44-281 (296) alignment 
Range on Protein: 1019-1244
Range on HMM: 44-281/296.0
EKNRRPLATPCNPETAVEVMSDGTRipiHANWINTSpDVDGNTQ--KFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEeKCHEYFPVR----T
|||| .   | .    |    ||     . ..||..  ||. ..  ..| |..|  .| |.||..|  .....||.|..  . .. ....|.| .     
eknrdvkvvPyDynRvvLekldGee...ksdYinav.yvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

GQIVdLERYKLKTVTQEQILGDSTSKR--TIQVEDTSKEFPTRTITHYQYHSWPD-QGIPQGHAQCFDLMNMAKE---------SKKPIVVHCSAGIGRT
|.|. .|  . |. .. .|      |.  ..  ...  . .||.....|.  |.  . .|   .   .|.....           ..|.||..| | .|.
geif.veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYW
  ..| .     |  .  . . .||  || .|   ...||.  .
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYky
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1020-1248 1.7e-38 127.0 In-house 59-277 (290) alignment 
Range on Protein: 1020-1248
Range on HMM: 59-277/290.0
KNRrPLATPCNPETAVeVMSDGTR-IPIHANWINtspdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDL
|||     .||  | | ...||     .|||...      |    || |||.| .|  |.| ||  .|| ..||||. .|.   ||..|.| . |... .
knr.ykdvvcndktrv.ilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

ERYKLkTVTQEQILGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRT
  . . . ..|.   . . |.|. | |  ..     . |..  ||||. ...     . .. . ..   |.||||||||||| .|.| .     .|  . 
Geitv.lcseeddkdaniikktlsvrdk.dsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGke

LVLNQAVAELRDQRWCAIQTVEQmYWVQVG
| | . |  ||. |  ..|   | | . | 
ldlldlvralrnsrlnsvqvdiq.ylalve
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1025-1246 4.1e-20 66.6 In-house 59-283 (310) alignment 
Range on Protein: 1025-1246
Range on HMM: 59-283/310.0
LATPCNPETAVEVMSDGTRI--PIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRT--GQIVDLER
    |  .. | .  | .|    ||||...|        . || .||||  |  ||| |.   . |....||. .|.   ||  |.|          .  
sdvvcldtsrvklkidksryedyihanyvktn....ylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirv

YKLKTVTQEQI---LGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANR
 .|   ..|     |  .     . |..   ..    ..  ..  |||.|.|. . .      .|.  . | |||||||..|.   .| ..    .    
tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrgl

TLVLNQAVAELRDQRWCAIQTVEQMYWVQ
 . ... ..||. .|   |||  |  ...
kvdaeevktellksraiciqtelqyliid
subfamily_PTPN9_pd Subfamily PTPN9 1028-1245 1.5e-38 127.5 In-house 52-282 (297) alignment 
Range on Protein: 1028-1245
Range on HMM: 52-282/297.0
PCNPETAVEVMS-DGT--RIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLK
 |  || | . . |..     |.||...       . . ||||||||..|..||| ||  ..| ..||  ..||.   || .|.|  ...  .   ....
lcydetrvvlakvdedeasdyinanfvdGy....kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs

TVTQEQIlgDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES-----------------KKPIVVHCSAGIGRTVSFIATQ
.| .|.   .   .|....... |.  .|..||.|. |||| |.|.  |...|......|                  . |||||||||||||  ||.  
nveveee..edykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitld

YIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
.  | .    |. . ..|  || ||  .||| || .. 
iclsrleevgtvdvvetvkllrtqrafsiqtpeqyefc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1028-1247 1.6e-35 117.4 In-house 45-264 (285) alignment 
Range on Protein: 1028-1247
Range on HMM: 45-264/285.0
PCNPETAVeVMSDGTRIPIHANWINTsPDVDGNTqkFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLK--T
 |  || | |. .  |  |||.|.   |  | .|  .|.||||||.|  ||| |.   |.  |.||| ..|   |||  |.| . |..| . .|..    
rcieetrv.vlknhdrdyihaswmrm.pgkdqst..yittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlte

VTQEQILGDSTSKRT-IQVEDTSKEfPtRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE---SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVL
. .| | |      | |. ||.| | |   . | |   ||||  |.      .| .  |.    .|||.||||||.||| .|.  .|    .. |  . .
ckeeaiagtilnaltvintedasse.p.lymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniem

NQAVAELRDQRWCAIQTVEQMYWVQV
 . | |.|  |. |.|.  |. .. |
ldivremramrfqavqshmqflflyv
subfamily_egg_pd Subfamily egg 1028-1245 9.6e-18 58.9 In-house 50-262 (307) alignment 
Range on Protein: 1028-1245
Range on HMM: 50-262/307.0
PCNPETAVEV-MSDGTRI--PIHANWINTSPDVdgntQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKeeEKCHEYFPVRTGQIVDL--ERYK
.|.  . |.. .  |  .   |||| ..  | .     .|| .| || || |||| ||   .|. .|||   .|   |.|. |.|    . . .    ..
hckdssrvklelrrGqylddfihanrvkGkpll....nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslr

LKTVTQEQ---ILGDSTSKRTIQVEdtskeFPTRTITHYQyhsWPDQGIPQGHaQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRT-
....  ..    |   |  . .  .        | . |.|   .  .   . .   . .. ....  ||.||..  |. .. ...| .     .|   . 
ienlkvdskadplfrvtklklvGgd.....deerflehwq...gdvnnssdvy.splrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpit

-LVLNQAVAELRDQRWCAIQTVEQMYWV
  .. .||  || .|  ....| .  .|
kslvlravvflrlrrrlsvesvllylfv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1030-1246 8.9e-43 141.2 In-house 32-257 (270) alignment 
Range on Protein: 1030-1246
Range on HMM: 32-257/270.0
NPETAV---EVMSDGTRIPIHANWINtspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTV
.|.| |   |. .| .   | ||...    .||...|.||..||||.|  .|| |.  .||...||. ...||  .||  |.| .... |.||  |.|..
sPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvl

TQEQILGDSTSKRTIQVEDTSKefpTRTITHYQYHSWPDQGIPQGHA---QCFDLMNMAKES-------K--KPIVVHCSAGIGRTVSFIATQYIPSAVL
....   .   .. ...|....   .| ..|..|..|||.|.|. .    .  .|..| ..        .  .|..||||||.|||  .||. ..  .. 
alseekeegyiltrlrleekge...errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe

ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
 .. . ... ..||| .|   .|..||. ...
etkkvdvlaiieelRkdRmalvqhpeqyefly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1033-1267 1.6e-22 74.4 In-house 62-251 (392) alignment 
Range on Protein: 1033-1267
Range on HMM: 62-251/392.0
TAVEVMSDGTripiHANWINTSP--DVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEeekcheyfpvrtgqivdleryklktvtqeq
  .||. | .    . ...|.|    .| | . .||.||| . . |||| ||  ..| |..|. .. | .                              
vkleviddip....dsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............................

ilgdstskrtiqvedtsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVA
                 |   .||.. ...  |||...|.  .  . ...  |       .|...|||||.|||   |. . . .     | . . . |.
.................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvt

ELRDQRWCAIQTVEQMYWVqVGSVYR--LSKEKNIDMKHYKEQ
..| .|   .|| ||  ..  |.|    | ..  | . |. ..
nirrkrpymvqtkeqyafi.ygavledllwrntlipvvhftdh
subfamily_CG42327_pd Subfamily CG42327 1033-1184 5.4e-15 49.9 In-house 43-192 (319) alignment 
Range on Protein: 1033-1184
Range on HMM: 43-192/319.0
TAV---EVMSDGTRIPIHANWINTSpdvDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIvDLERYKLKTVT-Q
| |   .. .|     ..|...      |     .||.| .| ..| ||| .|   .  ..| |..  |.  ..| ||.| . .   . . |    || .
trvvlqrigdddkdeyldasyvrGy...ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld.ntslyGdilvtlk

EQILGDSTSKRTIQVEDTSKEFpTRTITHYQYhSWPDQGIPQGHAQCFDLMNMAKE
..  .|     |. .    ||  .| .||| |  |.. ..|  .|  . ..  ...
grevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1034-1245 4.5e-34 112.6 In-house 49-258 (283) alignment 
Range on Protein: 1034-1245
Range on HMM: 49-258/283.0
AVEVMSDgTRIPIHANWINTSPDvDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqiVDLERYklkTVT-QEQIL
 ||. |. .|  | | .|  | . . . .|.|..|.|| .|  ||| ||  .|. ..||| .. | ...||  |.| |    .|   .   ||| ...  
rvelkse.srdyinavfipvsks.ykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs..edyGef...tvtlrkett

GDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGiPQGHAQCF---DLM--NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAE
 .| ... . .   |    |  ..|||.  | . | .|     .   ...  .  .. | |||||||.|||||  |||       .|..  . . . |  
snsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvki

LRDQRWCAIQTVEQMYWV
.| ||  |.|| .|   |
mreqrmmavqtldqyklv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1038-1244 9.2e-20 65.7 In-house 52-250 (267) alignment 
Range on Protein: 1038-1244
Range on HMM: 52-250/267.0
MSDGTRIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEeekCHEYFPVRTGQIvdlERYKLKTVTQeQILGDSTS
... ..  | | ....        ..||.||.|| ||  ||.|... .|| ..|.| .  . .    . ..| . ||    ..|.  || .  .  .   
lrtkeeeyinasyvegy....ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqa...kkyqdltveh.slekeend

KRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQ-CFDLM--NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWC
 . | .|   |.  .. .| | |. |  .   . . .  | ..  |  ..  .|.||.||.|.||. .|.  .     .  . .. . . . ..|.||  
yqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrig

AIQTVEQMYW
 ..| |.  .
lvdtkeryiy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1039-1259 5.1e-31 103.0 In-house 72-295 (325) alignment 
Range on Protein: 1039-1259
Range on HMM: 72-295/325.0
SDGTRIPIHANWINTspdvDGNTQKFIATQGPLPNTSDDFWTMVQFHKvETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlGDStSK
 |.    | |.....    | . . |.|.| ||..| .|.| .|   .  .||..   .......|  |.| . |. . .   ..| .| |.|  |   .
ddpssdyinasylrd....dkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdy.vh

RTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK----------ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAEL
| ..| ...|   ||..  .|. ||.| | ..  |    .... |          ..  ||.||||||.|||  ||.   .   |. .  . . . |  |
rvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkkl

RDQRWCAIQTVEQMYWVQVGSVYRL-SKEKNI
| .|   ..||.|   .  . |  . | . ..
rkdrpsmvetvdqyiliyealveaymsgntdv
0044763 (Phosphotyrosine protein) phosphatases II 1039-1246 1e-25 85.8 In-house 14-164 (178) alignment 
Range on Protein: 1039-1246
Range on HMM: 14-164/178.0
SDGTRIPIHANWINtspdvDGntqKFIATQGPlpntsDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqivdleryklktvtqeqilgdstsk
   .  .|.|..|      .|    ......|      |.. ... ... ..|.|.. .|   .||..|.| ..|                         
glersdyinaseil.....pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.........................

rtiqvedtskefptrtiTHYQYHSWPDQGIPQ---GHAQCFDLMNMAK-ESKKPIVVHCSAGIGRTVSFIATQYIPSAvlanrTLVLNQAVAELRDQRWc
                  .|..  .|| | |.      ....... |  |...|..||||||.||. ...|  .. .       | |..|....| .|. 
.................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.

AIQTVEQMYWVQ
.... .|.....
ivpnpgqlrqLy
0041856 (Phosphotyrosine protein) phosphatases II 1042-1247 1.7e-37 124.1 In-house 18-165 (182) alignment 
Range on Protein: 1042-1247
Range on HMM: 18-165/182.0
TRIPIHANWINTSPDVDGntqkFIATQGPLPNTSDDFWTMVQFHKVETVVMLCqfvekeeekCHEYFPvrtgqivdleryklktvtqeqilgdstskrti
    |.||..  |   .     ||||||||..|  ||..|.. ... |.|.|.         .. |.|                                
dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp................................

qvedtskEFPTRTITHYQYHSWPDQGIPQgHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAvlanrTLVLNQAVAELRDQRWCAIQTVEQ
       |. .|....|.|..||| |.|    ...|......|...|..||||||.||| ...|  .. .       . | .||...| .|.....| .|
.......ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnq

MYWVQV
....| 
yfflql
subfamily_PTPRN_pd Subfamily PTPRN 1042-1245 3.1e-27 90.1 In-house 78-284 (297) alignment 
Range on Protein: 1042-1245
Range on HMM: 78-284/297.0
TRIPIHANWINTSP--DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLerYKLKTVTqEQILGDSTSKR
.    . ..||.|.  | |  .  .|||||||..|  ||| ||  . |  .|.|..  |.. ..|..|.|    .. ..  |... |. | |  |    |
easaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi..yevhlvs.ehiwcddylvr

TIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGRTVSFIATQYIPSAVL-ANRTLVLNQAVAELRDQRWC
.. . .  ..  |||.| . . |||..|.|      ...      |      |||||||.| |||  .|. . . . .|   . . .  ..  |||||  
sfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpg

AIQTVEQMYWV
 ..| .|. ..
lvktkdqfefa
0043147 (Phosphotyrosine protein) phosphatases II 1043-1246 6.1e-37 122.4 In-house 5-154 (172) alignment 
Range on Protein: 1043-1246
Range on HMM: 5-154/172.0
RIPIHANWINTSPdvdgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFvekeeekcheyfpvrtgqivdleryklktvtqeqilgdstskrtiq
.  |.|......      ...||||||||.|| .||| |.. ... ..|.|...                                              
sdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

veDTSKEFPTRTITHYQYHSWPDQGIPqGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYIPsavlanRTLVLNQAVAELRDQRWCAIQ
   . .|. .|.. .|.|..|||.| |   ..  ....  .|     ...|..||||||.|||. ..|  ..       . | | .|||..|..|..|.|
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TVEQMYWVQ
. .|.....
npsqyrfly
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1043-1245 6.4e-36 118.8 In-house 63-270 (287) alignment 
Range on Protein: 1043-1245
Range on HMM: 63-270/287.0
RIP---IHANWINTSpDVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqiVDLERYKLKTVTQEqiLGDSTS
|..    | ..|| .  .||  . ..||....|. ||  .|| ... ..|...|||||  |..||.|..|.|  .   | |  |... . .|    ..  
rvllkgehpdyinav.fidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee..vnagyi

KRTIQVEDTSKEFPTRTITHYQYHSWPDQG-IPQGHAQCFDLMNMAK----ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQR
.|...|. ..|. ...... ||. .|...| ...  .  . . .| |    ... .||||||...||.  |.| .     .  . .. . | . . | |.
erklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqk

WCAIQTVEQMYWV
  ..|||||   .
pgsvqtveqykfi
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1044-1257 2.8e-30 100.1 In-house 68-279 (312) alignment 
Range on Protein: 1044-1257
Range on HMM: 68-279/312.0
IPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqIVDLERYKLKT--VTQEQILGDSTSKRTI
. ||||...       . ..|..||||| ||.  || ..      ....|| |||   ||| .|     | .|||| ... |  .|. .| | |  | | 
fyihanfvkic....tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdledhrvyteycteieiggkskdkith

QVEDTSKEF--PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
.|             . |||. ||||.|.|.    .. |.   |  |||.. |||||.||| ...  . . .|.   |   . ..   || .|  .....
rvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvf

EQMYWVqVGSVYRLSKEK
 |. .. . .|  .   |
pqyvya.lrcvleflysk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1045-1260 9.5e-42 137.8 In-house 75-294 (305) alignment 
Range on Protein: 1045-1260
Range on HMM: 75-294/305.0
PIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKT-VTQE---QILGDSTSKRT
 ||||.. |      |...|| || || .|  ||| |   .|||.. |||...||  .||.|||. . ......|    |  |  |   ..   . .| .
yihanyvstp....tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

-----IQVEDTSKEfpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVL-NQAVAELRDQRWC
     . .| . ..  .| .||| .  |||.|.|      ..|.. |. || ||||||||||||| | .  .||   .|| . .   .. .  .|.||  
vtetvlviegpgek..arkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnn

AIQTVEQMYWVQVGSVYRLSKEKNID
.||| .|  .|    .  . |.| .|
siqtdaqylfvhqvilnyfrkkklld
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1045-1246 2.8e-36 119.9 In-house 70-270 (315) alignment 
Range on Protein: 1045-1246
Range on HMM: 70-270/315.0
PiHANWINTSP--DVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlGDSTSKRTiq
| . ..||.|    || . . .||.||||. . |||| ||  .|| |.||. .  | .  ||  |.| | .. |..  .|....  |.  .| . ..   
P.dsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead.tdgvarkl..

VEDTSKEfpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
|   |.|  .||.| .|.. |||.|...  .  . |.   | ..     ...||||||.|||  .|. . . . .  .|.. . . | .||..|   .||
vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

VEQMYWVQ
 |.  .. 
eeeyafiy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1045-1245 6.9e-36 118.6 In-house 78-275 (290) alignment 
Range on Protein: 1045-1245
Range on HMM: 78-275/290.0
PIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIvdLERYKLKtVTQEQILGdSTSKRTIQVE
 |.| .|.       . ...||||||..||  ||| ... .||  .|||.. .|....||. |.| .  .   .. ...| ...|..|  .  .|...|.
yinAcyikgy....kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsik.llneetln.eyierklevk

DTSKEFPTRTITHYQYHSWPDQG---IPQGHAQCFDLMN--MAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
..... .....|.||  .|...|    ||.  . .  |.  . |. ...||||||...||.  |.|..     .  .    . | . ..| |.   .|||
nknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv

EQMYWV
.|.  .
qqyqgi
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1045-1243 1.1e-28 94.7 In-house 68-259 (281) alignment 
Range on Protein: 1045-1243
Range on HMM: 68-259/281.0
PIHANWINtSPDVdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKlktVTQE-QILGDStsKRTIQV
 ||||.|  || .    . .| ||||  .|  ||| |.   .  ..||||||.| . ||| ||||  .   ......    |. |   .  |    | ..
yihanyir.spfl...krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdkls...vsyedstvnks..lvttrl

eDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV-LNQAVAELRD-QRWCAIQTVEQ
 . | |  || |||. .. |||  .|.     . ..   .    | |.|||||.||. ...| .    .. .  ||  ..| |. ||   | ...||..|
.nlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq

MY
  
ym
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1045-1245 2.3e-10 34.6 In-house 71-271 (303) alignment 
Range on Protein: 1045-1245
Range on HMM: 71-271/303.0
PIHANWINTspdvDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRTGQIVDLERYKLKTVTQEQI-LGDSTSKRTIQV
 |||....     |  ..| | || ||. |. ||| |.   ||  |..|    | ..   .  || |  .....|   ..     .. |||  . . . |
yihasylel....d.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfeersirvgefkrvelgdgwvlkvlsv

EDTS-KEFptrtITHYQYHSWPDQGIPQG-----HAQCFDLMNMAKE--SKKPIVVHCSAGIGRTVSFIATQYIP-SAVLANRTLVLNQAVAELRDQRWC
 . . | |    .  ..|..|| . ||         | ..|  . .     .| |    .| ||. .|   .    |    . .| | . .  .|. |  
sngdyksf....lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlh

AIQTVEQMYWV
|.| . |.  |
avqnlsqfsvv
subfamily_PTPRB_pd Subfamily PTPRB 1046-1247 5.6e-45 148.6 In-house 82-279 (293) alignment 
Range on Protein: 1046-1247
Range on HMM: 82-279/293.0
IHANWINTspdVdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIvDLERYKLKTVTQEQIlgDSTSKRTIQVED
| ||.|.        ...|||||||||.| |||| ||  .|....||| | |||  .||.||.|  . ..      |.. |..|.   .    |....| 
inanyipg...y.nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeel..edwvirelkiek

tskEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK------KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
   |  .|....|.. |||| |.|.  ..  |.... .|..      .|||||||||.|||  ||| . . .|.  . .. .   ||||| .| . .||.
...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqte

EQMYWVQV
.|  ... 
kqYifihq
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1046-1246 4.1e-41 135.9 In-house 72-269 (281) alignment 
Range on Protein: 1046-1246
Range on HMM: 72-269/281.0
IHANWINTspdVDGnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRTGQIVDLERYKLKTVTQEQIlgDSTSKRTIQVed
| ||....   ..|  ...||||||.|.. ..|| ||  .||...||. . .|..  ||| |.|    . . .  ...|....|.    .  .|....  
inanfvpg...ykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeek..atyierkfkl..

TSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMA-----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLAN-RTLVLNQAVAELRDQRWCAIQTV
. .. .||.... .| .|||.|.|.  .. ..  .       |..| |.|.|||||.||| ..||   . .|| |. ..| ... ||||| .|   .|||
eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

EQMYWVQ
 |  .| 
vqyefvy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1046-1245 1.8e-38 127.4 In-house 72-272 (318) alignment 
Range on Protein: 1046-1245
Range on HMM: 72-272/318.0
IHANWINTSpDVDGN--TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDleryKLKTVTQEQILGDSTSKRTIQV
  ...|| .  .||.  ....||.|.|||.| .||| ||   .  ..||| | .|.  .|.| |.| .  .  .    ||.   .|..  ..   |...|
egsDyinan.yidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg....klvvelkeevelsdyvlrefkv

EDtSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
.  ..|  .|..  |.| ||||.|.|.  |.  ||.  ...     ...|||||||||.|||  ||| . .   . |. .. . | | .||.||   .||
tr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

VEQMYWV
 .|  ..
edqyefi
0051429 (Phosphotyrosine protein) phosphatases II 1046-1272 6.8e-37 122.9 In-house 7-244 (272) alignment 
Range on Protein: 1046-1272
Range on HMM: 7-244/272.0
IHANWINTSpdvdGN---TQKFIATQGPLPNTSDDFWTMvQFHKVETVVMLCQFVEKEEEKCHEYFP--------VRTGQIVDLERYKLKTVTQEQILGD
|.|.....     |.     ......||||.| .|||.. . ... |.|.|.. .|.. .||. | |        .      . . ..|   ... .| .
iNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

STSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHaqCFDLMNMAKEsKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV--------LNQAVA
 .  |..... ...   .|...|..|..||| |.||    . .|...  . ..|..||||||..||  ..|  ..   | ..  .         | .||.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

ELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNIDMKHYKEQFEMLD
|||.|| .|.|| ||.....   .  | .  .... ...  ....|
elraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid
0046846 (Phosphotyrosine protein) phosphatases II 1046-1246 3.2e-34 113.6 In-house 15-166 (176) alignment 
Range on Protein: 1046-1246
Range on HMM: 15-166/176.0
IHANWINTSpdvdgntqKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVdleryklktvtqeqilgdstskrtiqved
|.||.| .|        ..||||||||.|  ||. |.. .....||.|.. ||..  ||. |.|. ..  .                             
inanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

tskefptrtitHYQYHSWPDQGIPQGhAQCFDLMNMAKESK---KPIVVHCSAGIGRTVSFIATQyipsAVLANRTLVLNQAVAELRDQRW-CAIQTVEQ
           .|... ||| |.|.  .....|... .|     .|..||||||||||  ..|       .  .. | ...|.|..|.||. .|.|| ||
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

MYWVQ
.....
yrfly
0049772 (Phosphotyrosine protein) phosphatases II 1046-1246 6.4e-29 97.1 In-house 75-273 (314) alignment 
Range on Protein: 1046-1246
Range on HMM: 75-273/314.0
IHANWINTSpdvdgntQKFIATQGPLPNTSDDF----------WTMV--QFHKVETVVM---------------------LCQFVEKEeekcheyfpvrt
|.|.....        .|||||||||..| .||          |.||  . ..| ..||                     |... ..             
inasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............

GQIVDLERYKLKtvtqeqilgdstskrtiqveD--TSKEFPTRTITHYQYHSWPDqGIPQGHAQCFDLMNMAKE--SKKPIVVHCSAGIGRTVSFIATQY
.. .  .   ||                    .  ...|...|.. .| .. .|| | .   ..  ..... .|   ..|..|||.||.||| .|... |
neptaadlellk....................eelydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaay

ipsaVLANRTLVLNQAVAELRDQRW-----CAIQTVEQMYWVQ
    ..  . . |..|....| .|       .|.. ||.... 
....lmkllgvsleealedvrlkRpinpnpgfieqleqyefil
0051082 (Phosphotyrosine protein) phosphatases II 1046-1244 3.9e-27 90.1 In-house 6-144 (151) alignment 
Range on Protein: 1046-1244
Range on HMM: 6-144/151.0
IHANWINTSpdvdgntqkFIATQGPLPntsdDFWTMVQFHKVETVVMLCQFVEKEeeKCHEYFPVRTgqivdleryklktvtqeqilgdstskrtiqved
|.....            .....|||.    ||. ... ... |.|.|.. .| .  .|.||.|                                    
infsyvtgg.........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tskefptRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES-KKPIVVHCSAGIGRTVSFIATQYIPSAvlanrtLVLNQAVAELRDQRWCAIQTVEQMYW
       ....|.....|||.|.|.  ... ...... .  ..|..||||||.|||  ..|   .         . |..|..|.| .|. ..|. .|.. 
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1046-1243 1.2e-25 84.8 In-house 68-267 (287) alignment 
Range on Protein: 1046-1243
Range on HMM: 68-267/287.0
IHANWINTSPDvdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtGQIVDLERYKLKTVTQEQILGDsTSKRTIQVED
| ||.. .  |     ..|||.|||.. |  |||..|  ... .|... . ||.   ||..|.| |  . . .  | .  . ...   .  . |.... |
inanyvasytd....deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePe.ygvralrlid

TSKEfPTRTITHYQYHSWPDQGIPQG---HA----QCFDLMNMAKESK--KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAI
   .  .| .  ... ||||....      .    .. . ...|....   |.|||...||||.  ..||  . |  .    .   ..|. || .| . .
letr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalv

QTVEQMY
|.| |. 
qavvqlr
subfamily_PTPRD_pd Subfamily PTPRD 1047-1271 7.1e-47 155.3 In-house 80-300 (564) alignment 
Range on Protein: 1047-1271
Range on HMM: 80-300/564.0
HANWINTSPdvdgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtGqIVDLERYKLKTVTQEQiLgDSTSKRTIQVeDT
 |..|..      . ...|||||||..| .||| ||  ....|.||| . .||...|||.|.| . |     .... . . .|. |    . ||...  .
NAsfidgyr....krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeee.l.adyeirtfkl.kk

SKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK----ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQM
.|.  .|....... ||||.|.|.  ..  ||..  .    . ..|||||||||.|||  ||. ...   . ...|. . | |..|| ||   .|| || 
kkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQY

YWV-QVGSVYRLSKEKNIDMKHYKEQFEML
 .. ..   .  . .........|.....|
iFiheailealacgntevesenlkqhlqkL
subfamily_PTPN12_pd Subfamily PTPN12 1047-1246 9.4e-46 151.0 In-house 72-270 (290) alignment 
Range on Protein: 1047-1246
Range on HMM: 72-270/290.0
HANWINTspdVdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTqEQILGDSTSKRTIQVEDT
 ||.|.    |  .....||.|||||.| |||| |.. ..|| |||.|. || .  ||. |.| .... .  . ..... . |. . |    ||..||  
nanfikg...v.egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.ekavdddflirtLkveaq

SKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRT---LVLNQAVAELRDQRWCAIQTV
..   .|... ..|..|||.|.|... . ..|.....|    ...|.|||||||.|||   || .|. ... |...   | . . |.||| || ...|| 
ke...srkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk

EQMYWVQ
||   | 
eqyelvy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1047-1245 2e-35 116.9 In-house 70-268 (515) alignment 
Range on Protein: 1047-1245
Range on HMM: 70-268/515.0
HANWINTS--PDVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILGdsTSKRTIQVE
| ...|.|  | .| | . .||.|||.. . |||| .|  ..| |..|. .  | .  || .|.| . |. | .  .|...|. |   |  . ||...| 
hsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactg..gikrkltvl

DTSKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
  ..   .||.| .... |||.|.|.     . |.   | ..     |...|||||.|||  .|. . . . .   |.. . . |  .|..|   .|| |
kgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

QMYWV
|  ..
qyafi
subfamily_PTPRK_pd Subfamily PTPRK 1047-1245 2.6e-31 103.6 In-house 70-269 (314) alignment 
Range on Protein: 1047-1245
Range on HMM: 70-269/314.0
HANWINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILgdstsKRTIQVED
....||..  |   ....||.|||||..|  ||| .|  ..  ..||| ..||.   || .|.|  | .  |..   ..| ......     .|. .|| 
ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelv.....vrifrvek

TSKEF-PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMA----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
...    .|.. ..|. .||| ..|.     ..|.       .|.. .|||||||| |||  ||| . .   .  .... . .|| .||...   ..| |
largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvetee

QMYWV
|  ..
qykfi
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1047-1245 2.7e-30 100.4 In-house 76-271 (315) alignment 
Range on Protein: 1047-1245
Range on HMM: 76-271/315.0
HANWINTSpDVDGNT--QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtgqivDLErYKLKTVTQ-EQILGDSTSKRTIQV
|....|..  .|| .  ...||.|||.... .||| .|  ... ..||| . ||.|..|. .|.| .     ..  |   |||. ..   .  . ||. |
hsdyvnan.fidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kvi.yGkitvtrkseevnteytvrtlsv

EDTSKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK----ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
   ..    |..  ..| |||| |.|.      .|.  .|    .|  .||||||||.||| .||. . .   . |.. . . ...  .|..|  ..|..
vfgdn...irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

EQMYWV
||  ..
eqyqfi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1047-1247 7.5e-27 89.0 In-house 34-234 (239) alignment 
Range on Protein: 1047-1247
Range on HMM: 34-234/239.0
HANWINTS--PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERyklkTVTQEQILGDSTSkRTIQVE
|...||.|   | ||. . .||||| .  .| ||| |.   .   .|||  ..|  ..|||.|.|  | . ..|      |. . ... |    ||. . 
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv....tlrktevfadyii.rtfvms

DTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLM-NMAKES---KKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
.  .    | . .|..  |||.|.||  .  . |  ...|.|    .| |.|||||.||| .|.  . .      ..|. . . |  .|..|   .|| |
qvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QMYWVQV
|  ....
qyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1047-1246 7.8e-27 89.0 In-house 35-234 (239) alignment 
Range on Protein: 1047-1246
Range on HMM: 35-234/239.0
HANWINTS--PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERyklkTVTQEQILGDSTSkRTIQVE
|...||.|   | ||. . .||||| .  .| ||| |.   .   .|||  ..|  ..|||.|.|  | . ..|      |. . ... |    ||. . 
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv....tlrktevfadyii.rtfvms

DTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLM-NMAKES---KKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
.  .    | . .|..  |||.|.||  .  . |  ...|.|    .| |.|||||.||| .|.  . .      ..|. . . |  .|..|   .|| |
qvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QMYWVQ
|  ...
qyvfih
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1048-1245 3.8e-36 119.5 In-house 37-234 (250) alignment 
Range on Protein: 1048-1245
Range on HMM: 37-234/250.0
ANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEkCHEYFPVRTGQIVDLERyklKTVTQEQILGDSTSkRTIQVEDT
...|| |  ..  ... ||||||||..|  ||| ||  .|..|.||| ...|.|.. .|.|.|| . ..    .    .. .... .| |. |....  .
sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvt...vsllskeefadytk.rklklska

sKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES-----KKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQ
 |.   |.. .... .|||.|.|.     ..|..  . |     ..|..|.||||.||. .||| . .   .  .... . . .  || .|  |... ||
.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleq

MYWV
  .|
yvfv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1048-1245 1.4e-32 107.4 In-house 74-280 (302) alignment 
Range on Protein: 1048-1245
Range on HMM: 74-280/302.0
ANWINTSPDVDGNTQKFIATQG---PLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILGDSTSKRTIQV-
 .|| .   .||  .|   ..    |  .| . .|.... ..|  || ||.|||.||.|| ||.  . |. . . || .|||  .. | . | |..... 
ikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfkly

--E---DTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
  |   .  |.   .|.   .. .||| | |.   . .|...  .  || ..||||||.||| ...| .|     . ...  | . |  .|. |. |.|.
tveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd

VEQMYWV
 .|. ..
eqqliyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1048-1264 2.3e-31 104.0 In-house 79-296 (297) alignment 
Range on Protein: 1048-1264
Range on HMM: 79-296/297.0
ANWINTSpDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEeKCHEYFPVRTGQIvdLERYKLKTVTQEQILGdsTSKRTIQVEDTS
....| |  | || ...|.|| | ..| .|||.||  ..| |.||| .  |... ||  |.. .. .   .    ... . ..  |   .||...|.  .
sDyvnas.fvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereG..fikrelevtkgk

kEFPTRTITHYQYHSWPDQGIPQ--GHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
    .| .  ||. .|||. ...    ..  .|..  ..     .. |..|||.||.|||  ... . . . .  . .. . . |  ||..|   .|| |
.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtke

QMYWVQVGSV-YRLSKEKNIDMKHY
|  .| |  . . ||.. .|.....
qykfvyvavleallsedtriqasyf
subfamily_PTPN1_pd Subfamily PTPN1 1049-1245 2.2e-37 123.3 In-house 57-263 (290) alignment 
Range on Protein: 1049-1245
Range on HMM: 57-263/290.0
NWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTG-QIVDLE--RYKLKTVTQEQIlgDSTSKRTIQVE
..||.|  ...   ...| |||||||| | || ||  .|  .|||| ..||||. ||..|.|     . . ||  ..|.| ...|.   .    |....|
dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerk..syytvrllele

DTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES------KKPIVVHCSAGIGRTVSFIATQYIPSAVLA--N-RTLVLNQAVAELRDQRWCA
. . .  ||.|.|. | .||| |.|.  |. ....   .||      . | |.||||||||. .|.    .   . .  .  .. ... . ||| .|   
nlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGl

IQTVEQMYWV
||| .|. . 
iqtadqlrfs
subfamily_Ptp69D_pd Subfamily Ptp69D 1049-1246 2.2e-34 114.0 In-house 77-279 (307) alignment 
Range on Protein: 1049-1246
Range on HMM: 77-279/307.0
NWINTSPdVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtgQIVDLERYKLKTVTQEQiLGDSTsKRTIQVEDT
..|| |  . |  ...|||| |.|. .| .||| |.   .|...||| .  ||...||. |.|.   ..|  .    |.| .|.  .| . .|...|  .
dYinasf.ikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseek.hsdyi.iReldvskk

SKEF----PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMA----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
 .|      .| .. |.| .|.|  .|.     ..|....    | .. ||||||||| ||.  |.| . .   . |. .. . . | .|| ||   .| 
keesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

VEQMYWVQ
 ||  .. 
leqYvfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1049-1245 1e-30 101.7 In-house 30-231 (237) alignment 
Range on Protein: 1049-1245
Range on HMM: 30-231/237.0
NWINTS--PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRTGQIVDLERYKLKTVTQEQiLGDSTSkRTIQVEDT
..||..   ..||  .|.||.|||| .. |||| ||   |   .|||  ..|..|.|||.|.|  | |      . .    .|. . | |  |.. .   
dyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaaygvltvslkkkee.fsdytv.rslllskr

SKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLM-NMAKESK-----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
 .    | |  ||. ||||.|.||  |  . .  |. ..|.      | ..|||||.|||  |.  . .      .. . . . |  . ..|   ||| .
ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

QMYWV
|  ..
qyvfi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1049-1098 2.3e-07 24.7 In-house 71-121 (347) alignment 
Range on Protein: 1049-1098
Range on HMM: 71-121/347.0
NWINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVE
..||.|    |  ....| || |||.|  ||| ||.  ||  || . . ..
tyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1050-1245 2.7e-37 123.6 In-house 86-282 (298) alignment 
Range on Protein: 1050-1245
Range on HMM: 86-282/298.0
WINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVD---LeryklkTVTQEQILGDSTSkRTIQVED
.|| |  .   ... |||||.||..|  ||| ||  ....|.||| . .|... |.|.|.| .  .  .   .      .. ...  .| .. |...|..
YiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv......sllskeefadliv.rklkvsk

TSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----K-KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
...|  .|.. . .. ||||.|.|. .   .||..  . |    . ||..|.||||.||. .||| . .   | ..... . |.|  || .|  |.|| |
kkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

QMYWV
|  ..
qYvfi
subfamily_ptpA1_pd Subfamily ptpA1 1050-1206 5.3e-21 69.8 In-house 77-249 (418) alignment 
Range on Protein: 1050-1206
Range on HMM: 77-249/418.0
WINTSpDVDGN-TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQ----IVDL--ERYKLKTVTQEQILGDStsKRTIQ
.||.   .||   ..||.||||||||  ||| ||   ..  .||| .  |.   ||  |.| . |     |     | .   .|   ... |   .| | 
yinan.yidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdp..ereii

VED--TSKEFPTRTITHYQYHSWPDQGIPQgHAQCFDLM-----N------MAKESKKPIVVHCSAGIGRTVSFIAT
  .   . |  || ||.|||  |||. ||. |.| |  .     |       . . . ||.||||||.||| .| ..
trnirltfegetrditqyqyegwpdhnipd.htqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1050-1111 8e-07 22.9 In-house 124-181 (244) alignment 
Range on Protein: 1050-1111
Range on HMM: 124-181/244.0
WINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQfVEKEEekchEYFPVR
.||.|     | | ..| || || .|| ||| |.   .|. .|.|   ||.|.    ||.|  
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veeed....eywpds
subfamily_PTPN14_pd Subfamily PTPN14 1051-1245 1.2e-32 108.2 In-house 79-288 (300) alignment 
Range on Protein: 1051-1245
Range on HMM: 79-288/300.0
IN---TSPDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVR--TGQIVDLERYKLKTVTQEQILGDSTSKRTIQVED
||    .  | |.....|..||||..|  ||| ||  ..|. .||| .  |.  ||...|||      . |. ...|. |  .|.     |.. ...   
inassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp

TSKEfptRTITHYQYHSWPDQGIPQGHAQCFDLMNM-------------AKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQR
...|   ||. | ||  |||.|.|.   . .. ...             .|||| |..||||||.|||   | .. . ...  |... .....| || ||
skee...rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqr

WCAIQTVEQMYWV
   .||. |  .|
mllvqtlaqYkfv
subfamily_PTPN23_pd Subfamily PTPN23 1056-1242 5.6e-36 118.8 In-house 77-269 (288) alignment 
Range on Protein: 1056-1242
Range on HMM: 77-269/288.0
DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTvTQEQiLGDSTSKRTIQVEDTSKEfPTRTI
|.   . .|||||.||..|. ||| ||   |....||| .  |....|...|.| ..|. |  . ...    ...   .  ..|....|  ...  ....
dlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtl.ksvr.etethvervlkletldad.avksv

THYQYHSWPDQGIPQGHAQCFDLMNMAKE--------SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV-LNQAVAELRDQRWCAIQTVEQM
.| |..|||. |.|.   . ..... ...        ||.|.|||||||.|||  |     .  .. ..  |. . | |  || ||   .|..||.
shlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1057-1167 2.4e-06 21.9 In-house 23-125 (130) alignment 
Range on Protein: 1057-1167
Range on HMM: 23-125/130.0
VDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQfVEKEEekchEYFPVRTGqiVD-LERYKLKTVTQEQIlGDSTSKRTIQVEDTSKEFpTRTI
. |.|.... || || .|| ||| |.    |. .|.|   ||.|.    ||.|      ..  |   . |.|. .   .      ...|.  .|   ...
llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeed....eywpdseP..lewyeediivtltdrde.fknikasnleiesdlnes.hqal

THYQYHSWPDQG
| .|   || .|
tmfqisnwpsdg
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1058-1246 8.7e-21 68.9 In-house 85-272 (439) alignment 
Range on Protein: 1058-1246
Range on HMM: 85-272/439.0
DG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEekcheYFPVRT-----------GQIVDLERYKLKTVtqeqilgdstskRTIQVE
.|  . . .||||||  .|.|||| .|  .|. |.|||...||        |.|  .            . ..| .| .. .            . ..  
kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgf............kvfner

DTSKEfpTRTITHYQYHSWPDQGIPQGHAQCFDL---MNMAKESK--KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
||..    ||. ...| .|||. .|   .   |.   .| |....   |.|||||||.||| . || .     . ..  . ..  |  ||.||   .|..
dttek..ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal

EQMYWVQ
 |. ...
cqyvfiy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1060-1264 3.4e-34 113.6 In-house 102-303 (319) alignment 
Range on Protein: 1060-1264
Range on HMM: 102-303/319.0
NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCqfvekeEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlgdsTSKRTIQVEDTSKEFPTRTITHYQ
. .|.||.||||.|| .||| |.  ... |.|.|       ..|| .|.| .. .  .    |...|.. .        | |.. . .||   | || . 
rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirkitqfh

YHSWPDQGIPQGHAQCFDLMNM------AKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVY-R
.  |||.| |.  .. . |..        .. ...||||||||.|||  .|. . . . .  .. . . . | .||.||   .| . | ... .  .  .
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

LSKEKNIDMKHY
|    .. |  .
lfghsdvampdf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1060-1265 4.4e-34 113.3 In-house 66-268 (284) alignment 
Range on Protein: 1060-1265
Range on HMM: 66-268/284.0
NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCqfvekeEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlgdsTSKRTIQVEDTSKEFPTRTITHYQ
. .|.|||||||.|| .||| |.  ... |.|.|       ..|| .|.| .. .  .  . |...|.. .        | |.. . .||   |.|. . 
rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee....yvvrdielsedgkekdirkirqfh

YHSWPDQGIPQGHAQCFDLMNM------AKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVY-R
.  |||.| |.  .. . |..        .. ...||||||||.|||  .|. . . . .  .. . . . | .||.||   .| . |.... .  .  .
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

LSKEKNIDMKHYK
|    .. .  . 
lfghsdvalpdfp
0036282 (Phosphotyrosine protein) phosphatases II 1060-1246 1.4e-31 104.9 In-house 15-163 (174) alignment 
Range on Protein: 1060-1246
Range on HMM: 15-163/174.0
NTQKFIATQGPLPntsddFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVrtgqivdleryklktvtqeqilgdstskrtiqvedtSKEFPTRTITHYQ
 | ..||.||||.     || |.. ....|||||.. .|.. .||. |.|                                      .|...|.. .|.
itprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lredlerlgiqyl

YHSWPDQGIPQGHAqCFDLMNMAKES-----KKPIVVHCSAGIGRTVSFIATQYIPSAVLaNRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
|  ||| | |  .   ..... ..|      ..|..||||||.|||  ..|  ..    | ...    . |.||| || ...|| .|.....
ylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1060-1253 3.6e-12 40.3 In-house 88-285 (302) alignment 
Range on Protein: 1060-1253
Range on HMM: 88-285/302.0
NTQKFIATQGPLPNTS---DDFWTMVQFHKVETVVMLCQFVEKEEeKCHEYFPVRTGQIVDLERYKLKTVTQEQILGDStskRTIQVEDTSKEFPTRTIT
 |.. | .| |  ...   ..|| ||  .|. .||.| .  | ..   .|.|| ..|. .. ..  . .   |.  ..        .|   ...    ..
ltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek...tryviEvlPegcsnsvla

H-YQYHSWPDQGIPQGHAQCFDLMNMA----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVY
  |  . |... .|.  |.    .        ......|.    |.||  .|..     . . ..     .. |. .| || .|.....|   . .  ..
nvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

RL
 .
yi
0049260 (Phosphotyrosine protein) phosphatases II 1061-1246 1.2e-34 114.6 In-house 8-143 (152) alignment 
Range on Protein: 1061-1246
Range on HMM: 8-143/152.0
TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFpvrtgqivdleryklktvtqeqilgdstskrtiqvedtskefptrtitHYQY
 ..|||||||.||| .||| |.. ... |.|||....|. ..||..|.                                                .|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylh

HSWPDQGIPQGHAQCFDLMNM----AKESKKPIVVHCSAGIGRTVSFIATQYIPsavlanRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
. ||| | |. .    .|. .    |.....|..||||||.|||  ..|  ..       . . | .||| .| .|..|... .|.....
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_eak_pd Subfamily eak 1061-1191 2.7e-09 30.9 In-house 92-216 (332) alignment 
Range on Protein: 1061-1191
Range on HMM: 92-216/332.0
TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTvtQEQILGDSTSKRTIQVedtSKEFPTRTITHYQY
 .|.| |  .  .    || ||   |  ..|.| . ||.. ||   ||| .| . ..   .....  .| .  .    | ...   ||   |  . ||..
GrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver..kefvkrniletrllel...skGnethrvlhykv

HSWPDQGIPQgHAQCFDLMNMAKESKKPIVV
. | .  .|.   . . | .. ||   . ..
fGwtettlpk.yedflalrkvmkevGvllli
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1062-1220 2.5e-13 44.6 In-house 5-169 (199) alignment 
Range on Protein: 1062-1220
Range on HMM: 5-169/199.0
QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVdleRYKLKTVTQEQI--LGDSTSKRTIQVEDTSKEFPTRTITHYQ
...|||| || .|  ||| ||       .||. .   . |     |.|.         .|   .|| . |    | |    | ...|.    || |.|||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttktittkpdytitaliltnnttappstreishyq

YHSWPDQGIPQGHAQCfDLM--------NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV
. || ..  |.       ..        .  .|   |..|||| | | |  |.| .    .    .| |
ftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1062-1220 2.5e-13 44.6 In-house 4-168 (198) alignment 
Range on Protein: 1062-1220
Range on HMM: 4-168/198.0
QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVdleRYKLKTVTQEQI--LGDSTSKRTIQVEDTSKEFPTRTITHYQ
...|||| || .|  ||| ||       .||. .   . |     |.|.         .|   .|| . |    | |    | ...|.    || |.|||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttktittkpdytitaliltnnttappstreishyq

YHSWPDQGIPQGHAQCfDLM--------NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV
. || ..  |.       ..        .  .|   |..|||| | | |  |.| .    .    .| |
ftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1062-1114 6.1e-08 26.4 In-house 236-285 (440) alignment 
Range on Protein: 1062-1114
Range on HMM: 236-285/440.0
QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKeeeKCHEYFPVRTGQ
. ||||| ||  |  ||| .|. ... |..|| |. .|    |  |.|| |  
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrs
subfamily_hpo-7_pd Subfamily hpo-7 1073-1241 6.5e-27 89.1 In-house 45-215 (263) alignment 
Range on Protein: 1073-1241
Range on HMM: 45-215/263.0
NTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQilgdSTSKRTIQVED-TSKEFPTRTITHYQYHSWPDQGIPQG
.| | |. ...  | |.||||| | |.. ||| .|||.   .   |.  .. |    .     . ..|...    ..   |.|..||.|  |...  |. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpel

HAQCFDLMNMAKESkKPIVVHCSAGIGRTVSFIATQYIPS----AVLANRTLVLN--QAVAELRDQRWCAIQTVEQ
  . . ....|..| |..|||||.||||. .|  .  .      ..    |  |.  . . ||| .| .||.|  |
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1074-1241 8.8e-29 95.3 In-house 40-209 (255) alignment 
Range on Protein: 1074-1241
Range on HMM: 40-209/255.0
TSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTqeqILGDsTSKRTIQVEDT-SKEFPTRTITHYQYHSWPDQGIPQGH
| | |. ...  | |.||||| | |.. |||..|||.   .   |.  .. |        |    ||...  | ..   |.|..||.|. |...  |.  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssad.vvlrtleitstlgekkkthtvkhysykGWieknaPela

AQCFDLMNMAKESkKPIVVHCSAGIGRTVSFIATQYIPS----AVLANRTLVLN--QAVAELRDQRWCAIQTVEQ
 .   .. ....| |..|||||.||||. .|. ....      ..    |  |.  . . ||| .| .||.|  |
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq
0048076 (Phosphotyrosine protein) phosphatases II 1141-1246 1.5e-20 68.7 In-house 34-136 (145) alignment 
Range on Protein: 1141-1246
Range on HMM: 34-136/145.0
IQVeDTSKEFPTRTITHYQYHSWPDQGIP---QGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSavlanRTLVLNQAVAELRDQRWCAIQ
. .  . .|...|....|.| .||| |.|   .   ....... | ....|..||||||.||| ...|   . .     . . | .|....| ||..|..
lnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavp

TVEQMYWVQ
...|.....
npgqlrfly
0048179 (Phosphotyrosine protein) phosphatases II 1145-1246 1.1e-19 66.0 In-house 39-138 (144) alignment 
Range on Protein: 1145-1246
Range on HMM: 39-138/144.0
DTSKEFPTRTITHYQYHSWPDQGIPQG---HAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPsavlaNRTLVLNQAVAELRDQRWCAIQTVEQ
.  .||..|....|.. .||| |.|.      ....... | |...|..||||||.||| ...|   .       . | |..|.|..| .|..|... .|
eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

MYWVQ
.....
lrfLl
subfamily_PTPDC1_pd Subfamily PTPDC1 1148-1251 7.9e-09 30.2 In-house 76-174 (182) alignment 
Range on Protein: 1148-1251
Range on HMM: 76-174/182.0
KEFPTRTITHYQYhSWPDQGIPQGhAQCFDLM---NMAKESKkPIVVHCSAGIGRTVSFIATQYIPSavlanRTLVLNQAVAELRDQRWCAIQTVEQMYW
...  . |..|.. .|.| | .    . .|..   ..| . .  . ||| || |||   ||.  . .     . |  ..|.  .|..|  .||| ||.  
ealmeqgiyvynf.gwkDygvasl.eriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvel

VQVGSVY
|.  . .
vkefalf
PTPc_motif_SM00404 1148-1238 4e-07 25.0 In-house 42-127 (140) alignment 
Range on Protein: 1148-1238
Range on HMM: 42-127/140.0
KEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYipsavLANRTLVLNQAVAELRDQRWCAIQT
|| . ..| ... .    . . .   .. | .. |..... ..||| ||. |....|.  .     .  | | |..|.  ....| .  ..
kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl.....mryrqlslaeayefvkerRpiispn
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1151-1247 2.2e-10 34.5 In-house 87-188 (440) alignment 
Range on Protein: 1151-1247
Range on HMM: 87-188/440.0
PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK-----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 .||. .|.|..|||.|.|.  .  . ...  .||.      |..|||||| |||   || . |   .  .  . .   .  .|..|   .|| ||. .|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

QV
. 
he
DSPc Dual specificity phosphatase, catalytic domain 1151-1241 2.8e-07 25.5 Pfam-A 38-123 (133) alignment 
Range on Protein: 1151-1241
Range on HMM: 38-123/133.0
PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIAtQYIpsavLANRTLVLNQAVAELRDQRWCAIQTVEQ
. .. .... .   .. | .   .. . .. |....| ..||| ||| |. ..|.  |.    .  . | ||.|.. ....| .  .....
seieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii.aYl....mktknlslneAyefvkerrskispnagf
DSPc Dual specificity phosphatase, catalytic domain 1151-1241 2.8e-07 25.5 In-house 38-123 (133) alignment 
Range on Protein: 1151-1241
Range on HMM: 38-123/133.0
PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIAtQYIpsavLANRTLVLNQAVAELRDQRWCAIQTVEQ
. .. .... .   .. | .   .. . .. |....| ..||| ||| |. ..|.  |.    .  . | ||.|.. ....| .  .....
seieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii.aYl....mktknlslneAyefvkerrskispnagf
PTEN_1 1152-1245 9e-07 23.9 In-house 92-185 (196) alignment 
Range on Protein: 1152-1245
Range on HMM: 92-185/196.0
TRTITHYQYHsWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIAtqyipsAVLANRT-LVLNQAVAELRDQRWCA-IQTVEQMYW
 . ....... ..| | |  .  .  . ...       ... ..||| ||.||..  .|      | |  .  |  ..|.. .|..|... ... .|  .
ksgveylhfp.ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva......ayLmykgkltadeAlelvrekRppgapnspsqerl

V
.
l
PTPc_DSPc_SM00012 1154-1242 7.6e-21 69.7 In-house 1-96 (105) alignment 
Range on Protein: 1154-1242
Range on HMM: 1-96/105.0
TITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKK------PIVVHCSAGIGRTVSFIATQYIPSAVLAN-RTLVLNQAVAELRDQRWCAIQTVEQM
|..||.|..|||.|.|.     ..|..  |..|.      |.|||||||.|||  |.|  .. . . .. ... . | | |||.||  ..|| || 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
0038934 (Phosphotyrosine protein) phosphatases II 1156-1246 1.5e-08 30.1 In-house 68-170 (194) alignment 
Range on Protein: 1156-1246
Range on HMM: 68-170/194.0
THYQYHSWPDQGIPQGHAQCFDL------------MNM-----AKESKKPIVVHCSAGIGRTVSFIATQYIPSavlanRTLVLNQAVAELRDQRWCAIQT
. | .  ... ||   . .. |             ...     .. ... ..||| ||.|||  ..|   | .     . . ...|.| .|. |  ||..
ryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipn

VEQMYWVQ
.... ...
qdyleall
subfamily_CDKN3_pd Subfamily CDKN3 1159-1246 5.2e-07 23.4 In-house 103-189 (202) alignment 
Range on Protein: 1159-1246
Range on HMM: 103-189/202.0
QYHSWPDQGIPQgHAQCFDLMNM---AKESKKPIVVHCSAGIGRTVSFIATQYipsaVLANRTLVLNQAVAELRDQRW-CAIQTVEQMYWVQ
 ..  .| ..|.  |.| ....    . .. .  .|||  |.||.   ||       .. . |.  ..|...||| .   ||||| |  ...
hhypiadglvpd.iasclkileelrinlkayrktlvhcygglgrsslviacll....lylddtiepkdaidklrdlkgsraiqtvkqynyls
subfamily_DSP19_pd Subfamily DSP19 1160-1235 1.1e-07 26.3 In-house 63-133 (152) alignment 
Range on Protein: 1160-1235
Range on HMM: 63-133/152.0
YHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIaTQYIpsavLANRTLVLNQAVAELRDQRWCA
    |.. . .   ...| .. |....  ..|||.||. |..|..   |.    .....| |..|. ..|..| |.
ilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iayl....mkkeelsleealelvrearpci
subfamily_DSP23_pd Subfamily DSP23 1175-1244 2.8e-08 28.5 In-house 73-137 (148) alignment 
Range on Protein: 1175-1244
Range on HMM: 73-137/148.0
CFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIpsavlANRTLVLNQAVAELRDQRWCAIQTVEQMYW
   ... |.| .. . |||  | ||| ...|  ..      .| |   .|.||.| .|  ...||||   
fvrvveeaeekneavsvhcllgrgrtgtmlacylv.....kerklaaaeaiaevrrlrpgsvetveqekl
subfamily_CG42327_pd Subfamily CG42327 1182-1245 3.5e-09 30.8 In-house 243-307 (319) alignment 
Range on Protein: 1182-1245
Range on HMM: 243-307/319.0
AKESKKPIVVHCSAGIGRTVSFIATQYIPSAV-LANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 .||. |.||||| |.|||   ||.      .  ..|.. . | |  .| .|  |..|.||  ..
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1183-1243 2.1e-07 25.1 In-house 225-285 (297) alignment 
Range on Protein: 1183-1243
Range on HMM: 225-285/297.0
KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
.  . ...||||||.||.   . .. | . .  .|    .  .  ||.||   .||.||  
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1183-1214 2.2e-06 21.6 In-house 259-290 (350) alignment 
Range on Protein: 1183-1214
Range on HMM: 259-290/350.0
KESKKPIVVHCSAGIGRTVSFIATQYIPSAVL
..  .||.||||||.|||  ...  .. | ..
narsspilvhCsaGvGrtGtlvtlDsllsdfe