Gene Y71F9AL.4 in Caenorhabditis elegans

Synonym: CELE_Y71F9AL.4, Y71F9AL.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf11
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP228_AA protein Get Run
CeleP228_AA_157-431 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 153-441 2.1e-53 176.0 In-house 2-298 (305) alignment
Range on Protein: 153-441
Range on HMM: 2-298/305.0
KEQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKD--LNRYPNIQCWDRGRFTLAGDE-NFYIHANFVKICTKPERFVCTQGPMENTC
| |.   | |.   ..  .|. | .|..|.  .       || . ..   ||| .. | |. |  | |     |||||.|   |.|.||.||| |.|.||
kkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektc

THFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS----DIVGFVNlEDHR--VYTEYCTEIEIGGKSKDKITHRVLkVVVKATGQESKLNHYQWASWPDH
. || | |     .|.||| ..| |..||..|..    |.. | . ....  |  | ......  ..| |.|. || |.  . ..  | .|| |  ||| 
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee.kgqkisvkfessvtlkfrkdakakvtetvl.viegpgekarkvthyhwidwpdr

GMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDS-FVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQ
|.| .  . | ||   .  | |.. |||||.||||.. ..| ..  |   .. .  |  .. .|..|  |.||  ||..  . .|...  |.|.. . .
gvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevk

0050432 (Phosphotyrosine protein) phosphatases II 154-433 1.1e-73 243.6 In-house 26-302 (308) alignment
Range on Protein: 154-433
Range on HMM: 26-302/308.0
EQRAEMIKKWASAVMMSTPQQLTKEYKAVGNiVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLaGDENFYIHANFVKIC--TKPERFVCTQGPMENTCTH
    ...|.. .|  ..  ..  .|. .| . . . ..... . ||.|||..| ..|. |  | .... ||.|..|...   .| .|..||||..||. .
lsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntved

FWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDI--VGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSC
||.|    ... |.||. .||.| ||||.|  .    |... .. .|..  ...       .| .|.|.|... . .|.. ...|... .||||| |.| 
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

DTALRLLSAVKKD--KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
.  |..| .|.|   ..|.. |||||||||||..... ..  |.. .. .| . .  ||. |. .|||. ||..  |..||.|..|
eilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

subfamily_PTPRB_pd Subfamily PTPRB 154-433 6.9e-51 168.0 In-house 6-288 (293) alignment
Range on Protein: 154-433
Range on HMM: 6-288/293.0
EQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKF--KDLNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMEN
. ..|..... . .   .  ....||. . .. .| ...|  .   .. ||| ||  .|  |. |      ... || ||...  . |  |. ||||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIvgfvnledhrVYTEYCTEIEIGGKSKDKITHRV-LKVVVKATGQESKLNHYQWASWPDHGMP
|  .||.| .   |. |.||   || | .|| .|  .             . .  .|..  ..... .. |  .. .. . .| |...|.. ||||||.|
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad..........eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvP

DSCDTALRLLSAVKKD------KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
.. .| |... .|..       |.|...|||||||||||.  .. .. |...    ..    . ||..|.  |||  ||..  .|||..| .|
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 154-432 1.1e-43 144.6 In-house 8-292 (298) alignment
Range on Protein: 154-432
Range on HMM: 8-292/298.0
EQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVS-----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGP
|.  ....| |.     .  ....|.. . .. |      .| .   . |. |||..|  .|  |  |      .|  || | |..  .. . |. ||.|
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

MENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIgGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHG
...| . ||.|     ...|.||   .| .  |. ||  |       | .. | |   ..    ... ... | |||  | . .| .. . .. ||||.|
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPd.......egketygeitvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkg

MPDSCDTALRLLSAVKKD-----KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
.|    . | ||. |..      .|||| .|||||||.||   |.|..  ... ..  | .    |||.|. .|||  |||.    |||.| |
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 155-466 4.5e-227 746.5 In-house 1-312 (312) alignment
Range on Protein: 155-466
Range on HMM: 1-312/312.0
QRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQ
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
qraemikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwq

MALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALR
.||||||||||.|||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalr

LLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEWTKFKETYAKIK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||||||||||||||
llsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyakik

AKKLKIKDKSRG
||||||||||||
akklkikdksrg

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 156-447 1.4e-59 196.5 In-house 2-287 (288) alignment
Range on Protein: 156-447
Range on HMM: 2-287/288.0
RAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQM
. |.|  |   |.  . . | |||.   |  |    ..|..    .|| |. . |  |  |  | .|||.|| |     ..|..|.| |.. |   .|.|
kkevinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

ALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnlEDHRVyTEYCTEIEIGGKSKDKITHrVLKVVVKATGQESK-LNHYQWASWPDHGMPDSCDTALR
 |. .   |.||| ..| | || |.|    .|    |  |.   .|| .    .  ||. . |  . .. .|.|.. . .  .  |.|.|.|..  . ||
llesdveyivmlcellekGkeksaeyfPsklG....ekari.grlctvvkkkradidklvk.vsllriskegeekvivkilhlleWdddgvPenylsplr

LLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKgLYKRNEQEWTKFK
||  .|. .||.. |.||||||||||.||  .. .|| .    ..  .  ||..| ...||  ||.|. ||||| |  |  || . ....|. 
llevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk.kykvlredfvkla

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 156-429 4.5e-50 164.9 In-house 10-282 (290) alignment
Range on Protein: 156-429
Range on HMM: 10-282/290.0
RAEMIKKWASAVMMSTPQQLTKEYK-AVGNI--VSDSECTAFLKFK--DLNRYPNIQCWDRGRFTLA-GDENFYIHANFVKiCTKPeRFVCTQGPMENTC
..| ..|.|| |.  ....|.|||   .     |   |   | |      ||| .. | |. |  |  | .  |.|||.||  .|.  |. |||....| 
qteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk.Glka.mfiltqGalkdtv

THFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNleDHRVYTEYCTEIEiggKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSC
  .|.| |  . . |.|||  .|||  ||..|  .  | |       .|  |.| .   .  ..| ...| |  | .|.| ||.|..  ||||. .. | 
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevl..tfGeitvlcseed...dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst

DTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
 . ||.| ...|   ||. |||||.|||||.. ||  .  | . .. .. |    ||. |. |||   ||.  .. .|..
lallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

0036941 (Phosphotyrosine protein) phosphatases II 158-444 1.5e-72 239.7 In-house 5-291 (297) alignment
Range on Protein: 158-444
Range on HMM: 5-291/297.0
EMIKKWASAVMMSTPQQLTKEYKavgniVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMAL
 ..|.. .| ...  ..|.. ..       . ....... ...|||..| ..|. |  | .... ||.|..|...  . .|..||||..||. .||.| .
llekllflalllkefeellplll.....lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

SLGSTSIIMLCGFVEDGSEKCAKYISDI-VGFVNLEDHRVYTEYCTEIeiggkSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLL
 ...|.|.||. .||.| ||||.| ..   .... .| .| .  ....      .| .| |.|.|. . .|.. ...|... .|||||.|.| .. |...
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfi

SAVKK------DKKPVIAHCSAGVGRTGTLALIESMIAALR---HPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEWT
 .|.|      ...||. ||||||||.||..... |.  |.   . .. .... .  ||. |. .|||. ||..  ...||.|..| .. .  ....
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl

0051299 (Phosphotyrosine protein) phosphatases II 158-430 3.3e-69 228.8 In-house 8-286 (288) alignment
Range on Protein: 158-430
Range on HMM: 8-286/288.0
EMIKKWASAVMMSTPQQLTKEYKAVGNIVSDS--ECTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTH
| . |.  ..... . .| .|.... ..  |    .... . .. |||..| ..|. |  |      ... ||.|...... .. .|..||||..||. .
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVK----ATGQESKLNHYQWASWPDHGMPD
||.|    ... |.||...||.| ||||.| ..  |.....| .|..  ...       .|..|.|.|.|. .     .|.. . .|... .|||||.||
FWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

SCDTALRLLSAVKKD----KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
| .  |..| .|.|     ..||. |||||||||||..... ..  |.. .. .| . .  ||. |  .|||. ||..  ...||.|
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 159-431 4e-67 222.4 In-house 13-305 (307) alignment
Range on Protein: 159-431
Range on HMM: 13-305/307.0
MIKKWASAVMMSTPQQLTKEYKAVGNIVS----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFV--------KICTKPERFVCT
.. ..    . . .. | ||.. . ..      . ....... ||.|||..| ..|. |  |       ... ||.|..|        ... .. .|..|
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDhrvYTEYCTEIEIggksKDKITHRVLKVVVK-ATGQESKLNHYQWASW
|||...|. .||.|   .|.| |.||...||.|.||||.| .|  .... ..   .| .....|.    .|..|.|.|.|  .  ||.. ...|... .|
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgw

PDHGMPDSCDTALRLLSAVKK------DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRK---QNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
|||| |.| ...|... .|.|      ...||. |||||||||||....  |.  |..  .    .. . . |||. |  .||.. ||..  ...||.|.
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll





subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 159-452 3.1e-56 185.6 In-house 2-300 (307) alignment
Range on Protein: 159-452
Range on HMM: 2-300/307.0
MIKKWASAVMMSTPQQLTKEYKAVGNIVSD-SECTAFLKFKDLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQM
..| |    .    |.|. |.. . .   .     ||    | ||| ...| |.||  .   |    |||||.. |..|| .|.|.|||.|||  .|| |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwam

ALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRL
|.     |.||||  .| .  || .|     |  .   ..  |   ... ..  . |.    | .. |. ...   ..|.||  |||.|.|.   ||. |
aiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl

LSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAAL-RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSkgLYKRNEQEW---TKFKETYA
|.||. |. ||. ||||||||.||.  |  .   . .    ...|.    ||..|  ..||  ||.|  | .||..    |||   .|     ...| ||
leavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle..lyketyeellltknyeekya

K
|
k

subfamily_PTPRD_pd Subfamily PTPRD 160-449 1.4e-50 167.5 In-house 10-296 (564) alignment
Range on Protein: 160-449
Range on HMM: 10-296/564.0
IKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKF-KDLNRYPNIQCWDRGRFTL---AGDEN-FYIHANFVKICTKPERFVCTQGPMENTCTHFWQ
.|..   . ..  .....||| . .  . .  .|  .  |  ||| ||  .|. |  |    |||.  || |.|..  .|.. .. ||||...|.  ||.
lkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWR

MALSLGSTSIIMLCGFVEDGSEKCAKYISDIvGFVNLEDHRVYTEYCTEIeiggkskDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALR
|     |..|.||   .| | .||.||  .  |  . ..  |  | ..|.        ... | .|.  | . .  . ..... ||||||.|.|  . |.
mvweqnsstiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeel.......adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

LLSAVKK----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSkglyKRNEQEWTKFKET
|.. |..    |..|.. |||||||||||   |..|.  ... .. ..     .|||.|   |||  ||..  . .||.| .      .| |  ..|..
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac....gntevesenlkqh

subfamily_PTPN9_pd Subfamily PTPN9 161-361 1.5e-29 98.0 In-house 4-204 (297) alignment
Range on Protein: 161-361
Range on HMM: 4-204/297.0
KKWASAVMMSTPQQLTKEYKAVGNIVSDSECTA--FLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQ
..  . |     . |.|||... |     . .|         ||| .. |.|. | .||     ..  ||.||||    ... |. ||||...|.. ||.
eelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvNLEDHRVYTEYCTEiEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALR
|        |.|   .|| |  ||..|  .     . |.   ....  . ..  ..... ..|||..    |... |. |.|  ||||.|.|.|. . | 
mvWeqevlvivmttrvvergrlkcgqyWpl.....eeessaefgdlsvs.nveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslld

LLSAVKK
.|..|..
vlekvre

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 162-432 1.2e-41 137.8 In-house 12-285 (319) alignment
Range on Protein: 162-432
Range on HMM: 12-285/319.0
KWASAVMMSTPQQLTKEYKAVGNIVSDSECTA-FLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMA
.   |.  .. ..| ||.| . . |.|.  .|   . |. |||.||  .|| | .|.     ..  || |.|.    . |.|. ||.|.|||   ||.| 
erlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

LSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIGGKSKDKItHRVLKVVVKATGQE-SKLNHYQWASWPDHGMPDSCDTALRL
   .|  ..||.. || .  |. || ..       |.. .| ..  ..|   . .| |  | ||.  |..  |  .. |.|. .||||..|..  . | |
Weeessivvmltklveklkvklkkywpe.......enfeeyGrlivtleeeeeledyi.irklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
|  ..|     ...|.. |||||||||||   .. |.  ...    .|      ||  |   ||.  || .    .||.. .
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 164-433 1.9e-19 64.2 In-house 16-288 (302) alignment
Range on Protein: 164-433
Range on HMM: 16-288/302.0
ASAVMMS-TPQQLTKEYKAVGNI-VSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTC---THFWQMALS
| ... | . ....||.|.. .. |.  .|.|| |  . |. ..... |  .  |.. ...|..|  |..    .  . .| |  ..     .||.|. .
akklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

LGSTSIIMLCgfvedGSEKCAKYISDIVGfVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSA
   .|. .|      |.|.. | .|..    . .|.  | .    .    |.... |. |. |. .   .    | |    |... .|..  .. .    
ekivsvvilv.....geeelkktlselfp.kksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaak

V----KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
|     | .....     |.|| |..      .  | .  . |.|.    .|..|.|.|... |||   ...| ..  |
vfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 166-428 5.2e-44 145.6 In-house 15-281 (305) alignment
Range on Protein: 166-428
Range on HMM: 15-281/305.0
AVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDEN----FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGS
 . . . ..| ..||.. .  .  . .   . |  ||. .|.  |  |. |. .|.     || |..|.   . .... .|||..|| . ||.. .    
earvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

TSIIMLCGFVEDGSEKCAKYISDIVGfvnleDHRVYTEYCTEIEIGgKSKDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTALRLLSAVK
..|.||.. ||.| .|| .|  . ..     ... . |.  |..   |.    . | ||. .. . .||  . .||  .|||||.|..  . |.|.  |.
stivmltklveggkdkCrqYWpeskt.....ekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq

KD----KK-PVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
||    |. |.. ||||||||||.   .. ..  |..    .| .    ||. |   |||  |||.    . |
kdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde

subfamily_PTPRG_pd Subfamily PTPRG 166-435 4.9e-38 125.7 In-house 12-292 (563) alignment
Range on Protein: 166-435
Range on HMM: 12-292/563.0
AVMMSTPQQLTKEYKAVGNIVSDS--ECT--AFLKFKDLNRYPNIQCWDRGRFTL---AGDEN--FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMA
..  .. . ...|..|. . . ..  ...     . |  ||| ||   || | .|   .| ..   || ||...   | . |. ||||...|.  ||.| 
slhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmi

LSLGSTSIIMLCGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKaTGQESKLNHYQWASWPDHGMPDSCDTALRLL
    .. |.|.  .||.| .||  |     . ....  .|  .    . .  . . .| .. ||   . . .| .  .|....||||| |..    |   
WeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvLifv

S----AVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGL
     | |..  |.. |||||||||||.  .....  ...  . || .    .|  |   |||  ||..    .|| . ||  
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket

0039614 (Phosphotyrosine protein) phosphatases II 167-431 3.2e-67 222.4 In-house 26-290 (297) alignment
Range on Protein: 167-431
Range on HMM: 26-290/297.0
VMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENF-----YIHANFVKICTK-PERFVCTQGPMENTCTHFWQMALSLG
  .. ...| .|.. . ... | ..... . ||.|||..| ..|. |  | . ...     ||.|..|.   . . .|..||||...|. .||.|   .|
ekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqg

STSIIMLCGFVEDGSeKCAKYISDIVGfvNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVkaTGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK
.|.|.||. .||.|  |||.| .. .|  . .| .|..  ...       .| .|.|.|.|.   .|.. ...|.|. .||||| |.| .. |..| .|.
vtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.......ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

K------DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
.      ...||. |||||||||||....  |.  |.. .. .|.. .  ||. |  .|||. ||..  ...||.| 
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 169-443 9.5e-42 138.2 In-house 16-293 (318) alignment
Range on Protein: 169-443
Range on HMM: 16-293/318.0
MSTPQQLTKEYKAV-GNIVSDSECTAFLK-FKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGST
.|   .|..||...  .  . ..  .  .  |  ||| ||  .|. |  |   |      || ||..   .. . .. .|.|. .|.. ||.|    .|.
esGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

SIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIGGKSkDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-
 |.||   .| | .|...|  .       .. | | .   |..   .. .. . | .||  . . .. .   |...||||.|.|.|  . | |.  |.| 
vivmltqeeergkakvhryWPs.......kgsrsygklvvelkeevel.sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEW
    ...|.. ||||||||||.   .....  ...    .| .    ||. |   |||  ||..    .||.| |  ..   ..  
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlr

subfamily_PTPRN_pd Subfamily PTPRN 169-428 8e-25 82.1 In-house 25-290 (297) alignment
Range on Protein: 169-428
Range on HMM: 25-290/297.0
MSTPQQLTKEYKAVGNIVSDSECT---AFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVK-ICTKPERFVCTQGPMENTCTHFWQMALSLG
.. ...| ||..|. .  .. ...      |. . ||. ..  .|  | .|      ....|| | ..     .   .. ||||. .| ..||||    |
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

STSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK
.. |..|.   |.| ..|..|  |       | . ||  |  ..       |    | . .    | .   .  . . |||..|.| |  . | .   | 
vvvivnltrleeegvkqckrywpd.......eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn

KD----KKPVIAHCSAGVGRTGTLALIESMIAALRHP-RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
|       |.. |||.|.||||.  ||. ... | .  .. ..  .   || .|.  |.|  |. .|| .| |
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 170-435 5.9e-49 161.7 In-house 18-284 (288) alignment
Range on Protein: 170-435
Range on HMM: 18-284/288.0
STPQQLTKEYKAVGNIVSDSECTA--FLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTS
.. .....||... .. .... ||    . .. |||.||  .|  |  | .    ... || |....   | .....||||. .|  .||..     .. 
rnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IIMLCGFVEDGSEKCAKYISDivgfvnLEDHRVYTEYCTEIEiGGKSKDKITHRVLKVVvkATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK--
|.|| ..||.| .|| .|  |       .... | .   ..  . | ......| | ..   ...| ....||. .|||||.|.|    | ||. ||   
ivmltelveggktkCeeYWPd......adkpknyGsvtvtlv.eskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

--DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGL
  | .|.| |||||||||||   .. .| |...  . .| .    ||| ||  |||  ||..  ...|.  . .|.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 170-430 1.3e-27 91.3 In-house 12-293 (301) alignment
Range on Protein: 170-430
Range on HMM: 12-293/301.0
STPQQLTKEYKAVGNIVsDSECTAFL--KFKDLNRYPNIQCWDRGRFTLAGDEN------FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGS
   ... ..||.. .   | .||  |  . | |||. ||. .|  |..|.  .|       || |.... ... ..|. .||||..| . ||.. .    
khsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TSIIMLCGFVEDGSEKCAKYISD-------IVGF-VNLEDHRVYTEYCT---EIEIGGKSKDKITHRVLKVVVKAtgQESKLNHYQWASWPDHGMPDSCD
.||.|...  |.  .|| .| ..        . | | | .. || ..      . |   |... ..| .||  .   .  ..  .| ..||..|.     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrepr

TALRLLSAV-----KKDKKPVIAHCSAGVGRTGTLAlieSMIAALRHPRKQNVKDSFVL---LRKDRARSVQTFPQYVYALRCVLEFL
| |. .  |     | .. ||. |||..|.|.|.     |.  .|   . . | | | .   .|. .   |.|  ||.     . ..|
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYc...svsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Ptp69D_pd Subfamily Ptp69D 171-430 1.4e-39 131.1 In-house 20-286 (307) alignment
Range on Protein: 171-430
Range on HMM: 20-286/307.0
TPQQLTKEYKAVGNIVSDSECTAFLKFKD--LNRYPNIQCWDRGRFTLA----GDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSI
| . |.|||. . .  .| ....  |  .   |||..|. .|. |  |.     ..  || |.|.|   . ..|.. |.|.|.|   ||.|     .| |
tdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

IMLCGFVEDGSEKCAKYIS--DIVGFVnledhRVYTEYCTEieiggKSKDKITHRVLKVVVK-----ATGQESKLNHYQWASWPDHGMPDSCDTALRLLS
.||    |   .||||| .  |.| .       .  ..  |     ..... ..| |.|  |        .. |.  |.. .|.|  .|... . |.|..
vmlsnlteknrkkcakYWpiedevqyg.....dilvklvse.....ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

AV----KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
 |    |... |.. ||||||||.|..  ..|..  |.   | .. .    ||..|   || . |||.  | .|.. 
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_PTPRA_pd Subfamily PTPRA 171-433 3.8e-39 129.5 In-house 30-299 (330) alignment
Range on Protein: 171-433
Range on HMM: 30-299/330.0
TPQQLTKEYKAVGN--IVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLA---GDE-NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSI
  ... .|..|.    | .  | ..  . |. ||..||  .|  |  |.   | |   || | |..   . ..|. .||| |.|   ||.|     |..|
dnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati

IMLCGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEIEIGGKSKDKIThRVLKVVvkATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK-
.||  . |   ||||.|  |  | |   . ||  | .|...     |  .. .. .       ..  .. . . |||| |.|      |.|| .||| . 
vmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvq.qlpdat..rekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

---KPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF-LYSK
    |.. |||||||||||.  ...... ..  || .| .    ||. |.. |||  ||..  . .||. ||  
qsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 172-430 1.4e-45 150.6 In-house 14-276 (281) alignment
Range on Protein: 172-430
Range on HMM: 14-276/281.0
PQQLTKEYKAVGNIVSDSECTAFL--KFKDLNRYPNIQCWDRGRFTLA----GDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSII
 . ...||... .|  |.  ||    . .  ||| ||  .| .| ...      .. || ||||.  ....... ||||. .....|||| ..   . |.
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTeycteieIGGKSKDKITHRVLKVvVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV-----K
|.   .| |  || .|  |    ... | .| .       .  ..| .  .|..|.  . .|.. .... .. .|||||.|..    |   ..|     |
mvtreieagklkChrYWPddnselkygdvtvks.......taeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

KDKKPVIAHCSAGVGRTGTLALIESMIAAL-RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
| | |.. |||||||||||   .. .. |. .. .. .||.    |||.|   |||  || .  . ||. |
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 172-430 2.7e-39 129.9 In-house 4-268 (274) alignment
Range on Protein: 172-430
Range on HMM: 4-268/274.0
PQQLTKEYKAVGNIVsDSECTAFLKFKDLNRYPNIQCWDRGRFTLA---GDE--NFYIHANFVKICT-KPERFVCTQGPMENTCTHFWQMALSLGSTSII
...|.||.  .   . | | .   . .  ||| .|   .. | .|    ...    || ||..|    . . .| ||||. || . ||.|     .. |.
fkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLCGFVEDGSEKCAKYISdivgfvNLEDHRVYTEYcTEIEIGGKS-KDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK-
||  . |   .|||.|        . || ..  .| ...||  .. ...  ..| |.|.| . .| .. || ...||||  ||. .| |.|.  |.... 
mltklkeaneqkCavyfP......daedyeisery.gdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesre

----K--PVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
    |  ||. |||||.||||    |.  .  ||.  . .|    . || ||   |||  || .  | . ..|
eenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl

0040438 (Phosphotyrosine protein) phosphatases II 173-465 8.6e-72 237.4 In-house 18-311 (317) alignment
Range on Protein: 173-465
Range on HMM: 18-311/317.0
QQLTKEYKAV-GNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIML
..| .|.. .  ..... ....... ||.||||.| ..|. |  |  ..    . ||.|..|..  .. .|..||||..||. .||.|   .|.|.|.||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

CGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD----K
. ..|.| ||||.| ..  .... .| .| .  ..|       .. ||.|.|.|. . .... ...|... .||||| |.| |. |..|.||..     .
teleelgrekcaqYwpl.getltygdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

KPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEWTKFKETYAKIKAKKLKIKDK
.||. |||||||||||..... |.  |.. .. .|.. .  ||. |. .|||. ||..  ...||.|. |. ..   . ..|... ....  .. |.|.|
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkek

SR
..
el

subfamily_PTPN13_pd Subfamily PTPN13 173-430 1e-44 147.9 In-house 11-269 (273) alignment
Range on Protein: 173-430
Range on HMM: 11-269/273.0
QQLTKEYKAVGNIVSDSECTAFLK--FKDLNRYPNIQCWDRGRFTLAGDENfYIHANFVKICTKPERF--VCTQGPMENTCTHFWQMALSLGSTSIIMLC
|| ..|.| . .. .  .|.   |   || ||| |.  .|. | .| .. . || |...|.    ...  . .|||. .|.. ||||     .. |.|. 
qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

GFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYcteieIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK---KDKKP
  .|.|  || .|  .. .       |.  |      .. . .|  . | |.|  ...|.  .. | ....|||||.| | .  |.... |.   .|. |
lekekgkvkchrywPesknkklkvsnrlevel.....lkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagP

VIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
.. |||||.||.|||  |. ..  . . .. .||.    ||. |   |||  ||..  . .|| |
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 173-432 4.1e-36 119.9 In-house 34-294 (319) alignment
Range on Protein: 173-432
Range on HMM: 34-294/319.0
QQLTKEYKAVGNIV---SDSECTAFLKFKDLNRYPNIQCWDRGRFTL---AGDEN-FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSII
..|  |.... ..    .| . .   . || ||. ||  .|. .  |    | |   || | ||.   ...... .|||..||   ||.|     ...|.
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLCgfvedgSEKCAKYISDiVGFVNLEDHRVYTEYCTEIEIggkskdkITHRVLKVVVK--ATGQeSKLNHYQWASWPDHGMPDSCDTALRLLSAV----
.|        .||..|     . .. |   |  .  .| .         . | ...  .   ...  |.. . .  |||.|.||.    .||.  |    
llt......kdkcsqywpl.kivikeerfkvkvdsveetae.......yvvrdielsedgkekdi.rkitqfhflGwpdvGvpdypsdlmrlvkkvrhlt

--KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE-FLYS
  ........ ||||||||||.   .. ..  ... .. .| .    ||..| . || . || .    .|| .|..
skenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

0047943 (Phosphotyrosine protein) phosphatases II 174-430 7.4e-70 230.8 In-house 13-272 (273) alignment
Range on Protein: 174-430
Range on HMM: 13-272/273.0
QLTKEYKAVGNIVSDS--ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
.| .|.... ..  .   ..... . ||.|||..| ..|. |  | .... ||.|..|. . .. .|..||||..||. .||.|    ... |.||. .|
llleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelv

EDGSEKCAKYISDIVG--FVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK------DK
|.| ||||.| .. .|  ... .. .|..  ...       || .|.|.|... . ||.. . .|... .||||| |.| .  |... .|.|      ..
elgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

KPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
.||. |||||||||||..... ..  |.. .. .|.. . |||. |  .|||. ||..  ...||.|
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0045098 (Phosphotyrosine protein) phosphatases II 174-430 3.2e-61 202.5 In-house 10-272 (278) alignment
Range on Protein: 174-430
Range on HMM: 10-272/278.0
QLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTlagDenfYIHANFVKICtkPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVED
.|  |.. . .|.|. ..  .|. .|.|||..|...|. |     |   ||.|......  | .|..||||...|. .||.|  .||.|.|.||...||.
llefefllllgipseitpalylgnldknRykdilpydhsrVk...d...YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

GSEKCAKYISDiVGFVNLEDHRVYTEYCTEIeiggkskDKITHRVLKVVVK----ATGQESKLNHYQWASWPDHGMPDSC--DTALRLLSAVKK------
| ||||.|  .  |... .| .|... ....       |..|.|.|.|.      ..... ...|... .||||| |..   .  |.||  ...      
grekcaqywpe.ggsltygdftvtllseevl.......ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------DKKPVIAHCSAGVGRTGTLALIESMIAALrhPRKQNVKDSFVLLRKDRAR-SVQTFPQYVYALRCVLEFL
           ...||. ||||||||||||...  |.  |  ... .. . .  ||. |   .||.. ||..  ...||.|
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

0046845 (Phosphotyrosine protein) phosphatases II 175-434 3.5e-68 225.4 In-house 2-278 (284) alignment
Range on Protein: 175-434
Range on HMM: 2-278/284.0
LTKEYKAVGNIVS----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFVKIC-----TKPERFVCTQGPMENTCTHFWQMALSLG
| .|.... ...     . ....... ...|||..| ..|. |  |       ... ||.|..|. .      .. .|..||||..||. .||.| .  .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV
.. |.||...||.| ||||.| ... ......| .|..  ...       || .|.|.|... .  ||.. ...|... |||||| |.| .  |..| .|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.......kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

KKD------KKPVIAHCSAGVGRTGTLALIESMIAALRHPR---KQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKG
..       ..|.. |||||||||||..... ..  |.. .   . .| . .  ||. |  .|||. ||..  ...||.|..| 
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPN12_pd Subfamily PTPN12 175-432 8.5e-46 151.1 In-house 20-279 (290) alignment
Range on Protein: 175-432
Range on HMM: 20-279/290.0
LTKEYKAVGniVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGF
|...|||    |  .|..   . .  ||| .|  .|  | .|  .    .. || |||.|  ... ... .|||. .| . ||.|  .   . ..|.|  
lsekykaek..vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCre

VEDGSEKCAKYISDIVgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK----KDKKPV
|| |  ||..| .. .     |..  . |.. . |   . .| .. | ||| ..  ... |.. ... .|||||.| | .. |.|...|.    ....|.
velgkkkCerYWpeeg.....eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPl

IAHCSAGVGRTGTLALIESMIAALRHP---RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
. |||||||||||.  |. .  .|..     . .| |  . |||.||  |||  ||..  ..|.|.. .
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 175-430 2.1e-34 113.5 In-house 29-290 (310) alignment
Range on Protein: 175-430
Range on HMM: 29-290/310.0
LTKEYKAVGNIvSDS--ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE---NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCG
|.|.|. .     ||     |. |.   ||| .. | |  |  |  |    . |||||.||     . |.|.|||.. |   ||.| .   . ||..|| 
lvkqyrkldak.qdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

FVEDGSEKCAKYISDIVGFVNLEDHRV--YTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDS-CDTA-LRLLSAVKKdkKP
 .|.|  ||  |   .         ||  ..|   |.||   .   .   |      |  .| ...  .|  ||| |.||  | |   |||. |..   |
vgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gp

VIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
.. |||||..|..... ..  |  |..  | ....    |.|.||  .||  ||..  |  . | 
cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 175-430 1.1e-28 94.9 In-house 22-279 (439) alignment
Range on Protein: 175-430
Range on HMM: 22-279/439.0
LTKEYKAVGNIVSDSECTAFLKFKD----LNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIM
...... .. .  | .| | |  ..     ||| ..  .| .| ||          || ||..|   ... .. |||| ..|. .||.. .   .. |.|
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LCGFVEDGSekcakyisdivgFVNLEDHRVYTEYCTEIEIGGKsKDKITHRVLKVVVK--ATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV-----
|. .||               .   ... .| . .  ..   .   . . | .||. .   | .|  . .... .|||. .|  .   | .| |.     
ltnlvesyk............ywpsdaevcygdiavrvdrnie.lpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
|..  ||. |||||||||||.  ..  .  |.   | ..|    .|||.| . ||.. |||.   .||| .
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_PTPN14_pd Subfamily PTPN14 176-430 4.7e-39 129.2 In-house 26-296 (300) alignment
Range on Protein: 176-430
Range on HMM: 26-296/300.0
TKEYKAVGNIVSDSE--CTAFLKFKDLNRYPNIQCWDRGRFTLAGD---ENFYIHANFVKI--CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLC
 .||  . .   |..  ...  . .. ||....  ..  |  |.     .. || |  .|.  ..|   .. .|||.|.|.. ||||    | . |.|| 
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

GFVEDGSEKCAKYISDI---VGFVNLEDHRVYTEYCTeieiggKSKDKIThRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK-----
   ||| ||. ||. .       |. . ..|.|.. .      .|.  || . ||.    ...| .. | |.. |||||.|.  .. |  |  |.     
eeeedgkeksfkyfPkleskkktvefgkfkvttkfse......dsdsvit.tglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

--------KDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
        . | ||. |||||||||| | | . .||.| | .. ..| ..  ||. |   |||. || .  . ....|
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 176-428 4.8e-26 86.3 In-house 12-264 (283) alignment
Range on Protein: 176-428
Range on HMM: 12-264/283.0
TKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKIC---TKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVE
 . .| ..    |.....  . |  ||. .|   |. |  |  . . || | |. .     . .... .|.|...|   ||.|      |.|.||  . |
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

DGSEKCAKYISDiVGFvnlEDhrvYTEYCTEIEIGgKSKDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTA---LRLLSAV-KKDKKPVI
|  .||..|     |    ||   | |.   ..    ...  . . | . |... ...  | |||   | . |     ..     .. |   .. | |..
dlrikCsqyWPk.rGs...ed...yGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPiv

AHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
 |||.|.|||...  . . .  ..     .|      .|..|   |||  ||      |||
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 176-429 3e-21 70.6 In-house 9-258 (267) alignment
Range on Protein: 176-429
Range on HMM: 9-258/267.0
TKEYKAVGNIVSDS---ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVE
 ||.. . .| ..|    .    | .. ||. .   .|  |  |   |. || | .|.   . . |. ||.|..|| |.|...    . . |..|    .
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

DGSEKcakYISDIVGfvnleDHRVYTEYCTEIEIGGKSKD-KITHRVLKVVVKATgQEskLNHYQWASWPDHGMPDSC-DTALRLL--SAVKKDKKPVIA
|   .   .    .|     . . | .   |  .  . .| .|    ||.  ... ..  .  | .  |             . .|    ...  .|.. 
dnirl...fwPPkmg.....qakkyqdltvehslekeendyqiitlelkfknesa.hn..vtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

HCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
.||.||||.||.  |.|..  ...    .. | .  .|. |   |.|  .|.|  . . |.
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_CG7180_pd Subfamily CG7180 177-429 1e-21 71.8 In-house 21-289 (296) alignment
Range on Protein: 177-429
Range on HMM: 21-289/296.0
KEYKAVGNiVSDSECTAFLKFK--DLNRYPNIQCWDRGRFTL---AGDE-NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGF
.|.| . . ..  .| . |. .  . ||....   |  |  |    |.| . || | .|   .|.. .. |..|...|   ||..    .. ....|.  
lelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

VEDGSeKCAKYISDI--VGFVNLEDHRVYTEYCTEIEIggkSKDKITHRVLKVVVKATGQ---ESKLNHYQWASWPD-HGMPDSCDTALRLLSAVK----
 .    .. .|.       . ... . | ..  ....|    . |.|.... .  . ..    .  . ..|.  |.  . .| |  . . |.  |.    
fdfak.mypsywpnkskeqygeifveiveekqyanlki...rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre

K-----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
|     ...||. ..| |..|.|    |.  .  ...  . .| .    ||..| . |..  .| |    .||.
kvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

DSPc_SM00195 178-430 3.5e-62 205.5 In-house 5-262 (263) alignment
Range on Protein: 178-430
Range on HMM: 5-262/263.0
EYKAVGNIVS--DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
|.. . .  |  ....... | |. ||| || . |. |  |  .|    . ||.||..|. .|......||||...|. .||.| .  ... |.||. ..
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EDGSEKCAKYISDIVgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK----PVI
|.|.|||..|  .       ..  .....  ..    | ||.|. |.|..  ... .. |...||. .|||||.||| .  |.||.||||.|.    |..
engkekcdrywpees.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

AHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
 |||||||||||...|....  |..  | .... .  ||| |...|||. || .. ...||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 178-430 3.5e-62 205.5 In-house 5-262 (263) alignment
Range on Protein: 178-430
Range on HMM: 5-262/263.0
EYKAVGNIVS--DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
|.. . .  |  ....... | |. ||| || . |. |  |  .|    . ||.||..|. .|......||||...|. .||.| .  ... |.||. ..
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EDGSEKCAKYISDIVgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK----PVI
|.|.|||..|  .       ..  .....  ..    | ||.|. |.|..  ... .. |...||. .|||||.||| .  |.||.||||.|.    |..
engkekcdrywpees.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

AHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
 |||||||||||...|....  |..  | .... .  ||| |...|||. || .. ...||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 178-430 3.2e-36 119.4 In-house 16-269 (281) alignment
Range on Protein: 178-430
Range on HMM: 16-269/281.0
EYKAVGNIVSDSECTAFLKF--KDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGF
|.  .        ||.| .   .  ||| || | |  |  |       .   |||||...       .. |||| ..| . ||.|     .|.|.||| |
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

VEDGSEKCAKYISDIVgFVNLEDHRVYTEYcteiEIGGKSKDKITHRVlkvVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHC
.|   ||||.|.      . |.  ..  .|    |     |  .| |.    .   |.   . |. |  |||  .|.| .  |..|  ..    | . ||
letnrekcaeyfprna.hcclqfdklsvsy....edstvnkslvttrl...nlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihc

SAGVGRTGTLALIESMIAAL-RHPRKQNVKDSFVLLR-KDRARSVQTFPQYVYALRCVLEFL
||||||.|||  .|  . ..  |    ..|.    ||   || ||||. ||.   . .|.| 
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_ptpA1_pd Subfamily ptpA1 178-396 1.7e-24 81.3 In-house 26-262 (418) alignment
Range on Protein: 178-396
Range on HMM: 26-262/418.0
EYKAVGNIVSDSECTAFLKFK--DLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKiCTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
|.. . . |  || .   | .    ||| ||   .. |  |      . . || ||..   . |..|.|||||. || . ||.|        |.||    
efrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsres

EDGSEKCAKYISDIVGFVN----LEDHRVYTEYCTE-IEIGGKSKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD----
|.   || .|  . .|  .     .   |.  |  | .|.    . .|  | ... ..  |.   . .||.  |||| .||  .   .|| .. .     
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe..getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

------KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQ
      . |.| |||||||||||..    |.  | |  ||
ipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 180-441 9.7e-35 114.9 In-house 18-281 (285) alignment
Range on Protein: 180-441
Range on HMM: 18-281/285.0
KAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPE-RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKC
|  | .  .   ||.    ||||| ...| .  |  |   .  ||||.....  | .  .. ||||. .| . ||.|      . ..||| ..| | |||
kikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

AKYISDIVG-FVNLEDHRVYTEYCTEIEIGGKSKDKIThrVLkVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK---DKKPVIAHCSAGV
| |  . .|  |..  . .    | |  | |   . .|  |.     |. .   .|| |   |||.  |. .   . |   |||    .||.  ||||||
alyypeklgevvkfgkyeitlteckeeaiagtilnalt..vi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagv

GRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQ
||| |.  |.     .    . .. |    .|  | ..||.. |...    ..|..  .|. .|  |
grtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvvertgq

0043336 (Phosphotyrosine protein) phosphatases II 183-429 3.9e-64 212.1 In-house 31-276 (278) alignment
Range on Protein: 183-429
Range on HMM: 31-276/278.0
GNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKC
 . . . ....... ||.|||..| ..|. |  |  ..    . ||.|..|.   .|..|..||||...|. .||.|   ||.|.|.||...||.|..||
sfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkc

AKYISdiVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK----DKKPVIAHCSAGV
|.| .   |... .| .|..  ...       .| .|.|.|.|. . .|.. . .||.. .||||| |.| .. |..| ||..    ...||. ||||||
aqYwp..ggsltygdftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGv

GRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
|||||..... ..  |.. .. .. . .  ||. |. .|||. ||..  ...||.
gRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 183-438 4.1e-18 60.0 In-house 33-287 (303) alignment
Range on Protein: 183-438
Range on HMM: 33-287/303.0
GNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAgdENFYIHANFVKICTKpERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYI
. .  .     |.|  | ||. .. | |  .  |.  .  ||||..... ..  . . || |.  |.. |||| .      ...|    |  .      .
sylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

SDIVGFVNLEDHRVYTEYCTEIEIGgkskdkiTHRVLKVVVKATGQESKL-NHYQWASWPDHGMPDS-----CDTALRLLSAVKK--DKKPVIAHCSAGV
     |...|.  .      ..|.|          ||||.  . |.   .   ... .||   .|            .| | ..|  | .| .    .|.
prnqdflkfeersirvgefkrvelg.......dgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgc

GRTGTLALIESMIAALRHPR-KQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKR
||.||.||.|.   .|   .   ..   .  .|. |  .|| . |. .    . | .  .|. | 
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickl

subfamily_PTPN23_pd Subfamily PTPN23 186-428 9.5e-39 127.9 In-house 32-278 (288) alignment
Range on Protein: 186-428
Range on HMM: 32-278/288.0
VSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD
  .  ...  .. . ||. .|  .|. | .| | .. || | |||   .    |..||.|...|   ||.|  .  |  |.||    | | .|...|   
arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

IVGFVNLEDHrvyteYCTEIEIgGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK--------DKKPVIAHCSAGVGR
  |  .  ..     .   ..   .. ..  .||||. .. . .  .. | |. |||..|.|.| .| |..| .|..         |.|.. ||||||||
dkgetvkfgd.....lsvtlks.vretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

TGTLALIESMIAALR-HPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
||..||. . ...|. ..   .. . .  ||..|  .||.  |.  ..  |||
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 186-434 1e-33 111.5 In-house 33-287 (290) alignment
Range on Protein: 186-434
Range on HMM: 33-287/290.0
VSDSECTA--FLKFKDLNRYPNIQCWDRGRFTLA-----GD-ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEK
 |. . |     . | |||. ||   |  | ||       | .| ||.| ..|   . .... ||||..||  .||..     .| |.||.  .|.|..|
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CAKYISDivgfvnlEDHRVYTEYCTEIeIGGKSKDKITHRVLKVVVKAT-GQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCS
| .| .|       .| . | |.  .. .  .. .....| |.|  | . |..... .||  .|...|      | | ... . |      ..... |||
CqqYWpd.......sdtkaygefsikl.lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCS

AGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKG
..|||....  ..  |   .     .| .    .|  .  ||||  || .  . ||. |.|  
dtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 188-430 4.5e-43 142.2 In-house 11-264 (270) alignment
Range on Protein: 188-430
Range on HMM: 11-264/270.0
DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVK-ICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYI
.|.  .. . | |||| .|    . | .|.     ..  || ||.|. .  .........||...| ..||.| ..  .|.|.|. |..|.| .||..| 
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

SDivgfvnlEDHRVYTEYCTEIEIGGKSKDKI-THRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCD------TALRLLSAVK-----KDK-KPVIAH
.        | ..  .    .|..   |. |   ... .. .. .|.| .| |... .|||||.| . |        |..| ||.     .|| .|.. |
pa.......epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
||||||||||| ... .. .| . .| .|      |||||   ||.  || .. . |.|. 
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

0040439 (Phosphotyrosine protein) phosphatases II 189-431 7.4e-62 204.5 In-house 3-247 (249) alignment
Range on Protein: 189-431
Range on HMM: 3-247/249.0
SECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD
 ... ... ||.||||.| ..|. |. |   .    . ||.|.... .  . ||..||||...|. .||.|   ||.|.|.||. .|| | ||||.| ..
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

iVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK------DKKPVIAHCSAGVGRTG
  |... .| .| .  ...       ||..|.|.|... . .|.. . .|.|. .||||| |.| ...|... ||.|      ...||. ||||||||||
.ggsleygdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
|....  |.  |.. .. .... . |||. |  .||.. ||.. ....||.|.
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 189-432 2.5e-35 117.3 In-house 17-258 (284) alignment
Range on Protein: 189-432
Range on HMM: 17-258/284.0
SECTAFLKFKDLNRYPNIQCWDRGRFTL---AGDEN-FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvedgSEKCAKYISD
 . .   . || ||. .|  .|. .  |    | |   || | |..   ...... ||||..||   ||.|     ...|..|        .||..|   
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

iVGFVNLEDHRVYTEYCTEIEIggkskdkITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTALRLLSAV------KKDKKPVIAHCSAGVGRT
  . .. |  .|  .  .| |         . | ...  ..  .   |.. . .  |||.|.||.    .||.  |      ........ |||||||||
.kivikeerfkvkvdsveesee.......yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE-FLYS
|.   .. ..  ... .. .| .    ||..| . || . || .    .|| .|..
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

0042113 (Phosphotyrosine protein) phosphatases II 190-430 1.1e-60 200.4 In-house 2-243 (245) alignment
Range on Protein: 190-430
Range on HMM: 2-243/245.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDi
....... ||.|||..| ..|. |. |  |.    . ||.|..|. .  ...| .||||...|. .||.|  .||.|.|.||. ..|.| .|||.| .. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

VGFVNLEDhrvYTEYCTEIEIggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTL
 .... .|   .| .....|.    .|..|.|.|.|. . .... . .||.. .|||||.||. .. |..|..|.|     ...||. |||||||||||.
gesltygd...ftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf

ALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
...  |.  |.. .. .. . .  ||. |  .|||. ||..  ...||.|
iaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 190-419 5.3e-40 132.0 In-house 44-270 (301) alignment
Range on Protein: 190-419
Range on HMM: 44-270/301.0
ECTAFLKfKDLNRYPNIQCWDRGRFTLAGD-ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIV-G
|  |.|. || .|||.. |       .  | .   ||||...   .|.||..||||..||.  || |        |.||. .||.  |||..|..  .  
esyaylp.kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

FVNLEDHRVYTEYCTEIeiggkSKDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESM
 .... ... ..    |      ..||..| |.|.  .   ..  . |||...|.|.|.| |      |.  ||| .||.. |||||.||. ..   | .
kldigrfkikiknkeli.....lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteyl

IAALRHPRKQNVKDSFVLLRKDRARSVQTFPQY
  ..   .. ......  ||..| ..|||  | 
areveadptieltealkhlrehrwngvqtnsql

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 190-428 3.9e-17 57.0 In-house 40-342 (350) alignment
Range on Protein: 190-428
Range on HMM: 40-342/350.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLA------------GDENFYIHANFVKIC-----TKPE-RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
. .  ..    ||| ||  ... |  |                | || ||..|.       .|. ... ||.|. .|   |... |  . . |..|   |
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EDGSEKCAKYISDI------VGFVNLEDHRVYT----EYCTEIEIGGK------SKDKITHRVLKVVVKATGQE-SKLNHYQWASWPDH---GMPDSCDT
| . ||| .|  .       | . .  .  . .     | .....          . .. .    . ....  .   . . |.  |.|      | |  .
elnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilq

ALR--------LLSA---VKKDKKPVIAHCSAGVGRTGTLALIESMIA---ALR----HPRKQ----NVKDS----FVLLRKDRARSVQTFPQYVYALRC
||         | .     ..  .|.. ||||||||||||  ..|..     |.    . ||     ...|        ||| | . ||.  |...   .
alevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea

VLE
.| 
llf

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 190-306 6.6e-08 26.4 In-house 27-145 (332) alignment
Range on Protein: 190-306
Range on HMM: 27-145/332.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLA---GDENFYiHANFVKICTKPERFVCTQGPMEN-TCTHFWQMaLSLGSTSIIMLCGFVEDGSEKCAKY-ISD
    ||.  |.|| | . |.|. |  ||   | ..||  |..|   .|   .. .| |... |   ||.| .|    |.|.. | ...  .. | | |||
tydkflnnmdmnriphlycfdhsrvelapqdgkddfy.naswvdgyskksayifaqapfndhteyvfwrm.vserkpsmilvfgdidekqkrkapydisd

iVGFVNLEDHRVYTEYCTEIEI
  || .   | . ..   | |.
.rgfeksflhefgaksleecel

0037934 (Phosphotyrosine protein) phosphatases II 191-429 6.7e-55 181.6 In-house 4-241 (243) alignment
Range on Protein: 191-429
Range on HMM: 4-241/243.0
CTAFLKFKDLNRYPNIQCWDRGRFTLAGdeNFYIHANFVKICtkpERFVCTQGPMENTCTH----FWQMALSLGSTSIIMLCGFVEDGSEKCAKYISdiv
.  ..  .. |||..| ..|..|  | |  . ||.||....    .|. .||||...|. .    ||.|  .||.|.|.||. .|| | ||||.| .   
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

gfvnlEDHrVYTEYCTEiEIGGKSKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK------------KDKKPVIAHCSAG
     ... .| ... .  .. ...|..|.|.|... .  ....    ||.. .|||||.|||..  |..|..|.            ....||. |||||
.....gev.tygdftvt.llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTLALIESMIAALrhprKQNVKDSFVLLRKDRAR-SVQTFPQYVYALRCVLEF
|||||||...  |.  |    . .. . . |||. |   .|||. ||..  ...||.
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPN1_pd Subfamily PTPN1 194-428 1.8e-44 146.6 In-house 29-269 (290) alignment
Range on Protein: 194-428
Range on HMM: 29-269/290.0
FLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS--DIVGFVNL
. . ..|||| ... .|  | .|  ..| || |..|..     ... ||||. ||..|||||     | ...||  .|| .. |||.|    . .  . |
lpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

EDHRVYTEYCTEieiggKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK------KDKKPVIAHCSAGVGRTGTLALIES
|| ..  .. .|     ..|.. | |.|..  . | .  .. |. . .||| |.|.|  . |..|  |.      .|. |.. |||||.||.||..|...
edtklkvklise.....erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

MIAALRHPRK---QNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
... . .  .    ..|. .. ||| |   .||  |  ..   .||
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPN6_pd Subfamily PTPN6 194-432 8.3e-39 128.4 In-house 51-299 (306) alignment
Range on Protein: 194-432
Range on HMM: 51-299/306.0
FLKFKDLNRYPNIQCWDRGRFTLAGD---ENFYIHANFVK--ICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVgf
  . |  ||| ||  .|  | .|. .   .. || ||..|  . .. .... ||| .|.| . ||.|..   |. |.|.   || | ||||.|  |    
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee..

vNLEDhrvYTEYCTEiEIGGKSKDKITHRVLKVV-VKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD--------KKPVIAHCSAGVGRTGT
 . |.   | ..  . ..  ||... . | |.|  .|  ..| .. .|.. ||||||.| . .. | .|. |..         . |.. |||||.|||||
.ekee...yGkisvt.nvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGt

LALIESMIAALRHP---RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
. .|. ..  ...     . .....  ..|. |   |||  || .  . . ... .
fiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

0049772 (Phosphotyrosine protein) phosphatases II 194-431 3.5e-30 101.2 In-house 43-281 (314) alignment
Range on Protein: 194-431
Range on HMM: 43-281/314.0
FLKFKDLNRYPNIQCWDrGRFTLaGD----ENFYIHANFVKICtkpERFVCTQGPMENTCTHF----------WQMAL--SLGSTSIIM-----------
... .| |||..|...|  |  | .        ||.|..|. .    .|..||||.|.|.  |          |.| |   | .  | |           
lflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCGFVEDGSEKCAKYISDIVgfvnledhrvyteycteieI-------GgkskdkithrvlkvvvkatgqESKLNHYQWASWPDHGMPdSC
          |... . |.| .|... ..                                                  |    .| .  .||.. | . 
rLdaAlgKtpllildgngneptaadlellk...................eelydpelf.....................erlgikylripvpDgsap.ll

DTALRLLSAVKK--DKKPVIAHCSAGVGRTGTLALIESMIAALrhprKQNVKDSFVLLRKDRA-----RSVQTFPQYVYALRCVLEFLY
.  ...| ....  ...||. ||.||.|||||....  .. .|    . .... .  .|. |      ...... ||.. |...||.| 
edfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 196-433 9.9e-36 118.4 In-house 51-287 (297) alignment
Range on Protein: 196-433
Range on HMM: 51-287/297.0
KFkDLNRYPNIQCWDRGRFTLAGDENF----YIHANFVKICTKpeRFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFvEDGSEKCAKYISDiVGFVNL
.| . .|| ||   |. | .||  ..     |. | |||   .  |...|| ||..|   ||.| |    . |.||    ... .|||.| ||  | ...
nf.eksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsd.kgvttf

EDHRVYTEYCTEIEiGGkskdkiTHRVLKVVVKATGQESKLNHYQWASWPDHGMPD--SCDTALRLLSAVKKDK-----KPVIAHCSAGVGRTGTLALIE
 |  | ..  .| | |.       .| |.|   .. ..  .. ||. .|||. ..   |  . | |.| |.||       |.. ||.||||||| |  |.
Gdvsvvllsvsere.Gf......ikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltid

SMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
|..|  ..  . .. .    ||..|   |||  || .    |||.|.|.
svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 196-429 3.1e-32 106.7 In-house 48-278 (315) alignment
Range on Protein: 196-429
Range on HMM: 48-278/315.0
KFKDLNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIvgfvnl
. |. ||| ||   |. |  |      ..  |. |||..  .|..|....|||  ..   ||..      . |.|| . ||.  .|. ||  |       
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk......

edHRVYTEYcTEIEIGGKSKDKITHRVLKVVVKATGQEskLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMI
  . .| .. |   .  . ....| | | ||..   .|  .  ....|||| |.| .. . . |   ||. .     ... |||||||||||.  .....
..kviyGki.tvtrkseevnteytvrtlsvvfgdnire..vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

AALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
  .   .  .| .    .|. | . ||.  || .    .|| 
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_PTPRK_pd Subfamily PTPRK 197-429 3.9e-37 122.7 In-house 43-276 (314) alignment
Range on Protein: 197-429
Range on HMM: 43-276/314.0
FKDLNRYPNIQCWDRGRFTL---AGD-ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnle
 .. ||. .|   || | .|    || .. || |...   ..|. |. ||||...| . ||.. .  ...||.||  .|| |  || ||  .        
nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe........

DHRVYTEYCTEIeIGGKSKDKITHRVLKVVV--KATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESM
| .|| .   |. .  . . .. .|...|    ..  .  .....|. .||||..| |  . |.|.  ||| .     ... ||||| |||||   |...
dtevygdikvel.vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

IAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
.  ... .  .|      ||. .   |.|  ||..    .|| 
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 197-435 4.8e-35 115.9 In-house 47-283 (287) alignment
Range on Protein: 197-435
Range on HMM: 47-283/287.0
FKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRV
 ||.||. .|   |  |  | | .. || | |..   .  .|. ...|| ||   ||..      | |.|||   |.  |.| .| ..       |.  |
nkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe.......eksvv

YTEYCTEIEIGGkSKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHG-MPDScDTALRLL-SAV----KKDKKPVIAHCSAGVGRTGTLALIESMIaa
. ||  |.      ... . | |.|  |  .|.. ... || ..|...| ...   | | ..   .    |. . ... |||..|||....  ..  |  
lGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaatti..

lRHPRKQNVKDSFVLLR---KDRARSVQTFPQYVYALRCVLEFLYSKGL
 .. ... | | | .|.     .  ||||  || .    |||.| |  .
.nkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 197-431 2.1e-34 113.5 In-house 44-277 (515) alignment
Range on Protein: 197-431
Range on HMM: 44-277/515.0
FKDlNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVG----F
||  ||| ||  .|. |  |       .. |. | ...       ....||| . .   ||.. |    | |.|.    |.   ||.||  |. |    |
fkk.nryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

VNLEDHRVYTEYCTeieiggkskdKITHRVLKVVvKATGqESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIE
 ... . | .| ||            . | |.|. |       .  ...  |||.|.|  . . |.|. .|| |.     |.| |||||||||| .  |.
Gsikvelvsleact..........ggikrkltvl.kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

SMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
|..|  .  |  .| .    .|..|   |||  || .    ||| |.
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 197-432 2.1e-27 91.1 In-house 48-290 (325) alignment
Range on Protein: 197-432
Range on HMM: 48-290/325.0
FKDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGsTSIIMLCGFVEDGSEKCAKYISDIVGfvnle
 |. ||..|.   |. |  |       .  || |....   | . |. .| |. .|   .|...|    .|....   .. | ..||.|  . .|     
nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemg.....

DHRVYTEYCTEIEIGGKSKDKItHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK----------KDKKPVIAHCSAGVGRTGTLAL
. . .     ..    .  | . ||||.|     |.   .. .|. ||.| | .    | . .|  ||          |   |.. ||||||||||... 
ksktfGglevklrtieeisdyv.hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
. |..| . .  . .. ..   |||||   |.|  ||.    .. |.. |
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 198-434 4.8e-41 135.6 In-house 10-246 (250) alignment
Range on Protein: 198-434
Range on HMM: 10-246/250.0
KDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEkCAKYISdivgfvnLED
|. ||| .|  .|  |  |  ..      || | |..  .. . |. ||||...|  .||.| |   |..|.||  ..| . . . .|.         | 
keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.......vek

HRVYTEYCTEIEIGGKsKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIA
 . | .   ..    . .  .|.|.||.  .   .|  . .... .||| |.|.   ..| ||. |..     ...||| .|||||||.|.   |.... 
aekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

ALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKG
 |.. .. .| .    ||||| ..|..  |||.  . .|..| | .
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 198-428 1.6e-27 91.2 In-house 8-238 (239) alignment
Range on Protein: 198-428
Range on HMM: 8-238/239.0
KDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVG-FVNL
|  ||| ||  .|. |  |        . || |....     |. ...||| .| ..  ||.|        |.|| |..|   .|| .|  |    ..||
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

edhRVyTEYCTEIeiggkSKDKITHRVLKVVVKATgQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMi
   || |   ||.       | | . ..   |  | .|  . .|... |||.|.|. . . | |   . ||     .| . ||||||||||.. .|..| 
...rv.tlrktev.....fadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam.

aaLRHPRKQNVKDSF---VLLRKDRARSVQTFPQYVYALRCVLE
  ||. .||.  | |     .|.|| . |||  |||.   .|||
..lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 198-428 2e-27 90.9 In-house 9-239 (239) alignment
Range on Protein: 198-428
Range on HMM: 9-239/239.0
KDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVG-FVNL
|  ||| ||  .|. |  |        . || |....     |. ...||| .| ..  ||.|        |.|| |..|   .|| .|  |    ..||
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

edhRVyTEYCTEIeiggkSKDKITHRVLKVVVKATgQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMi
   || |   ||.       | | . ..   |  | .|  . .|... |||.|.|. . . | |   . ||     .| . ||||||||||.. .|..| 
...rv.tlrktev.....fadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam.

aaLRHPRKQNVKDSF---VLLRKDRARSVQTFPQYVYALRCVLE
  ||. .||.  | |     .|.|| . |||  |||.   .|||
..lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 198-427 5.2e-27 89.4 In-house 39-274 (287) alignment
Range on Protein: 198-427
Range on HMM: 39-274/287.0
KDLNRYPNIQCWDRGRFTLAGDENF---YIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEdh
   ||| ..  .|  |  |. . ..   || ||.|   |. |.|...|||.  |   ||.. |   |.|.|..   ||..  || ||  .    . .   
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG..

rVYTeyCTEIEIGGKSKDkITHRVLKVVvKATGQE-SKLNHYQWASWPDHGMPDSCDTALRLLSAV---------KKDKKPVIAHCSAGVGRTGTLALIE
  |.   . ..   |. .  . | |... .. ..|   .. ... ||||.... ..   .|.   |          ..  |.. |...|.||.|.|  . 
.Gys..vvlldydikePe.ygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

SMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVL
 ..  |    . .|    . ||. ||  ||.  |. .    . 
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

Y_phosphatase Protein-tyrosine phosphatase 199-428 9.9e-58 190.7 Pfam-A 3-235 (235) alignment
Range on Protein: 199-428
Range on HMM: 3-235/235.0
DLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISdivgfVNLEDHRV
. |||..| . |. |  |   .... ||.||.||  .....|..||||...|. .||.| .   ...|.||.  .| |.||||.| .      . |.   
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.....eeeeeslt

YTEYCTEIEIGGK-SKDKITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAAL
| ... |..   |  ....| |.|..  |.. . . ....... .|||||.|.| .  |.|. .|.|.|    .||. |||||||||||..... ..  |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
.. .. .|..    ||| |. .||.. ||..  ...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 199-428 9.9e-58 190.7 In-house 3-235 (235) alignment
Range on Protein: 199-428
Range on HMM: 3-235/235.0
DLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISdivgfVNLEDHRV
. |||..| . |. |  |   .... ||.||.||  .....|..||||...|. .||.| .   ...|.||.  .| |.||||.| .      . |.   
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.....eeeeeslt

YTEYCTEIEIGGK-SKDKITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAAL
| ... |..   |  ....| |.|..  |.. . . ....... .|||||.|.| .  |.|. .|.|.|    .||. |||||||||||..... ..  |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
.. .. .|..    ||| |. .||.. ||..  ...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0041856 (Phosphotyrosine protein) phosphatases II 199-433 4.6e-42 139.0 In-house 3-174 (182) alignment
Range on Protein: 199-433
Range on HMM: 3-174/182.0
DLNRYPNIQCWDRGRftlagdENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvedgsekCAKYISdivgfvnledhrvyt
|.|||..| ..|..|       . ||.||..  . .. ||..||||. .|. .|..|  .|| |.|..|.         .  |                 
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

eycteieiggkskdkithrvlkvvvkaTGQESKLNHYQWASWPDHGMPDsCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAAlrhprKQNV
                           .  |    .|.. .||||| ||  |..|... .|.....||. ||||||||||||...  |.       . ..
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

KDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
 . . |.|. |  .|.|  ||..  ...||.|. |
eeavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 199-431 3.3e-25 83.3 In-house 47-237 (392) alignment
Range on Protein: 199-431
Range on HMM: 47-237/392.0
DLNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGsekcakyisdivgfvnledh
  ||| ||  .|. |  |       .. |. | ...     . ....|||   .   ||.| .    |.|.|.  . |                      
kknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....................

rvyteycteieiggkskdkithrvlkvvvkaTGQESK-LNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAA
                                |.. .    .... |||...|    . |...  || |     .|.| |||||||||| .  |.|..| 
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

LRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
 .. |  .| .  . .|. |   |||  || .   .||| | 
akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_PTPN3_pd Subfamily PTPN3 200-429 9.8e-46 150.9 In-house 44-274 (280) alignment
Range on Protein: 200-429
Range on HMM: 44-274/280.0
LNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKP----ERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHR
 ||| .|  .|  | .|   |. || ||.|..         |.. ||||...|.|.||||     |. |.||   ||.|  || .|  .    ... . .
knryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefs

VYteyCTEIeiggKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAALR
|.   |..     ... ..  | | .  |.| .| |. . |. .|||||.||. .  |.... |.| .    .||. |||||.|||| | |.|  .| . 
vk...ceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalie

HPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
. .. .. |    .|  ||  |||  || .   ..|. 
aaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 200-433 2.5e-43 142.8 In-house 58-292 (305) alignment
Range on Protein: 200-433
Range on HMM: 58-292/305.0
LNRYPNIQCWDRGRFTLAGDE-NFYIHANFVKICTKPE-RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnlEDHRVY
 ||| .. | |.    |.      |||||.|     || ||.|.|||...|  .|| | .      |.|||  || |  |||.|     |    | . . 
knryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg....eklelk

TEYCTEIEIGGKSKDK---ITHRVLKVVVkATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPR
.    |   | |  ..   |   .|..   . .|.  . | ||. ||| |.|    |.| ||||..  | |.. |||||.|||||.  || ..  .   .
sgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenk

KQN-VKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
.   . .    || .|| |.|.  ||..  | .|...  |
pcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 200-431 2.9e-34 113.3 In-house 47-278 (315) alignment
Range on Protein: 200-431
Range on HMM: 47-278/315.0
LNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD----IVGFVNL
 ||| ||  .|. |  |       .. || | ..|   . . ....||| . .   ||.| |    |.|.|.    |.   ||..|  |     | | ..
knryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsi

EDHRVYTEYCTeieiggkskdKITHRVLkvVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK----PVIAHCSAGVGRTGTLALIESMI
. . . .| .|            ..| |  |.. . .  ..  .|.  |||.| .    . |.|. .|| |..    ... |||||||||| .  |....
kvellsleadt..........dgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

AALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
| ... |  .| .    ||..|   |||  .| .    ||| |.
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 200-428 3.5e-34 113.1 In-house 6-237 (237) alignment
Range on Protein: 200-428
Range on HMM: 6-237/237.0
LNRYPNIQCWDRGRFTLA--GDENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIvgfvnlEDHRV
 ||| ||...|  |  |   | .  || |...|     | .....|||.|..|  ||||      . |.|| |..|   .|| ||  .       .. . 
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst......dqpaa

YTEYCTEIEIGGKSKDkITHRVLKVVVKATGQESKLNH-YQWASWPDHGMPDSCDTALRLLSAV-KK-----DKKPVIAHCSAGVGRTGTLALIESMIAA
|  .   .    .  |  | | | .... | .| .| | ||..||||.|.|. . . ||.   . ..     .  | | |||||||||| . .|..|.  
ygvltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
 .  .  .. .    . .||   .||  |||.  . .||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_egg_pd Subfamily egg 201-431 1.1e-24 81.7 In-house 44-271 (307) alignment
Range on Protein: 201-431
Range on HMM: 44-271/307.0
NRYPNIQCWDRGRFTLAGDEN----FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDgsEKCAKYISDIVgfvnLEDHRV
 | . ..| |  | .|   .      .|||| ||     . |...| |. ||   ||.|        |.||   .|   |.|  |          .  ..
arskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae....sdslvt

--YTEYCTEIEIGGKSKDKITHRVLKVvVKATGQESKLNHYQWaswpDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIA-ALRHP
   .   . ...  |.    .   ||. | .  .|  |.|.|.    |        . ||.|  ...  |||. ..  || ...||  ||  .   || |
vpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGp

-RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
  |. |. . |.||. |  ||..  .|..  | || |. 
itkslvlravvflrlrrrlsvesvllylfvyrlvlfffr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-353 4.7e-20 66.6 In-house 37-187 (297) alignment
Range on Protein: 201-353
Range on HMM: 37-187/297.0
NRYPNIQCWDRGRFTLAG--DENFYIHANFVKICTKPE--RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFvNLEDHRV
||| .|   |  |  | .   |. || |..|    ...  .....|||...|   ||..    .   |.|.. . ||| .||| |  ..|.  .|.   |
nryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe.rlkagdv

YTEYCTEIEIGgksKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTAL
  |. ..        |..    |... .   .. ...| |. ||||||.|   .   
vveflsstsde...fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 217-284 1.4e-06 21.9 In-house 86-155 (349) alignment
Range on Protein: 217-284
Range on HMM: 86-155/349.0
AGDENFYIHANFVKICT--KPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD
.|  . || ||..|.      .....|| |.  |   |... |  |   .. |    | . ||| .|  .
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe

subfamily_CG42327_pd Subfamily CG42327 218-360 1e-16 55.5 In-house 53-191 (319) alignment
Range on Protein: 218-360
Range on HMM: 53-191/319.0
GDENFYIHANFVKICT-KPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnLEDHRVYTEYCTEIEiGGKSKDKITH
 |...|..|..|.     |  ....| ..|.. . ||..     |  |. |.   | | ..||.|.    .   |.....| ..   .  |...||.   
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket...ldntslyGdilvtlk.grevkdryai

RVLkVVVKATGQES-KLNHYQWaSWPDHGMPDSCDTALRLLSAVK
  | .. .  ..|| .| || .  |.. ..| .  . . .|  |.
stl.llkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 218-276 4.7e-06 20.4 In-house 119-176 (244) alignment
Range on Protein: 218-276
Range on HMM: 119-176/244.0
GDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTsIIMLCGFVEDGSE
   | || | ||    .   .. || |. .|   ||.| |      .... | ||.  |
smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvn.vlvvlgsveeede

0043147 (Phosphotyrosine protein) phosphatases II 219-423 8.4e-37 121.9 In-house 3-154 (172) alignment
Range on Protein: 219-423
Range on HMM: 3-154/172.0
DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFvedgsekcakyisdivgfvnledhrvyteycteieiggkskdkithrv
. . ||.|...... .| ||..||||. ||. .||.|  .|| | |..|...                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lkvVVKATGQESKLNHYQWASWPDHGMPdSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIaalrhpRKQNVKDSFVLLRKDRARSV
   .. ... |    .|.. .||||| | . .  |..|. ...     ...||. ||||||||||||...  |.      .. .. . . |.|. |  .|
...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav

QTFPQYVYAL
|.. || . .
qnpsqyrfly

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 220-276 1.9e-06 22.2 In-house 12-67 (130) alignment
Range on Protein: 220-276
Range on HMM: 12-67/130.0
ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLgSTSIIMLCGFVEDGSE
.| ||.|.|| .  .   .. || |. .|...||.| |      .... | ||.  |
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmler.yvnvlvvlgsveeede

0046846 (Phosphotyrosine protein) phosphatases II 221-429 3.7e-34 113.4 In-house 12-172 (176) alignment
Range on Protein: 221-429
Range on HMM: 12-172/176.0
NFYIHANFVKICtkpeRFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNledhrvyteycteieiggkskdkithrvlk
  ||.||..  .    |...||||...|. .|..| ..|| | ...|.  || |. ||. | ... ..                                
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

vvvkatgqesklnHYQWASWPDHGMPDScD---TALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIEsmiaALRHPRKQNVKDSFVLLRKDRA-RSVQTF
             .|..  ||||| ||. .   ..|...  . |...||. |||||.||||||...      |.. .  .| . . |.|. |  ..|||.
.............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

PQYVYALRCVLEF
 || .  ...|..
eQyrflyefelll

0036282 (Phosphotyrosine protein) phosphatases II 222-422 6.8e-33 109.2 In-house 3-162 (174) alignment
Range on Protein: 222-422
Range on HMM: 3-162/174.0
FYIHANFVKICTKPERFVCTQGPMEntcthFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnledhrvyteycteieiggkskdkithrvlkv
 ||.|.....   ..|....|||..     ||.|  .||.|...||.  .|.|..||  | ..                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

vvKATGQESKLNHYQWASWPDHGMPDSCDtALRLLSAVKKD-----KKPVIAHCSAGVGRTGTLALIESMIAALRhPRKQNVKDSFVLLRKDRARSVQTF
  . .  |    .|..  |||||.||.    |.....|..      ..||. ||||||||||||...  |.  |. .. ... | .  ||. | ..|||.
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

PQYVYA
 || . 
sQyrfl

0044763 (Phosphotyrosine protein) phosphatases II 222-425 2.1e-25 84.8 In-house 19-166 (178) alignment
Range on Protein: 222-425
Range on HMM: 19-166/178.0
FYIHANFVKictkPERFVCTQGPmentcTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnledhrvyteycteieiggkskdkithrvlkv
.||.|...     |  ......|      .....   || |.|..|.. .| | .|| .|  .  |                                  
dyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................................

vvkatgqesklNHYQWASWPDHGMPD---SCDTALRLLSAVK-KDKKPVIAHCSAGVGRTGTLALIESMIAAlrhprKQNVKDSFVLLRKDRArSVQTFP
            .|..  .|||| ||    .. ..... ..  ....||. ||||||||.|||...  |.       . .. . . |.|. |   |... 
...........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QYVYALRC
|. . ...
qlrqLyef

subfamily_eak_pd Subfamily eak 222-350 2.1e-08 27.9 In-house 79-199 (332) alignment
Range on Protein: 222-350
Range on HMM: 79-199/332.0
FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvNLEDHRVYTEYCTEIEIGgKSKDKITHRVLKV
 || |  ..     .... |  . |.    |||| |   | .|..|   || . ||  ||  |     .  .   .  .  |       ....  | |..
GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd.....ktreelkfGildverkef.vkrniletrllel

VVkaTGQESKLNHYQWASWPDHGMPDSCD
 .    .  .. ||.   | .  .|   |
sk..GnethrvlhykvfGwtettlpkyed

0051429 (Phosphotyrosine protein) phosphatases II 223-432 5e-38 126.6 In-house 6-227 (272) alignment
Range on Protein: 223-432
Range on HMM: 6-227/272.0
YIHANFVKICTK---PERFVCTQGPMENTCTHFWQMaLSLGSTSIIMLCGFVEDGSEKCAKYIS-----------DIVGFVNLEDHRVYTEYCTEIEIgg
||.|..|.  ..   | |. ...||...|. .||..  .|| ..|..|.. .| |..|| .|.            | . .... ..||.. ...  .   
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld..

kskdkITHRVLKVVVK-ATGQESKLNHYQWASWPDHGMPDSCdtALRLLSAVKKdKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQN--------VK
     ...|.| .. .  .|.  .. |... .||||| |..    |.||... . ..||. |||||..||||....  ... . .    .        . 
.....yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

DSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
.    ||. |. .|||  ||.. ....||.|.|
eaveelraqrpgavqteeqylflyeallellrs

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 223-453 1.4e-26 88.3 In-house 48-286 (290) alignment
Range on Protein: 223-453
Range on HMM: 48-286/290.0
YIHANFVKiCTKPERFVCTQGPMENT-------CTHFWQMALSLGSTSIIMLCGFVEDGSE----KCAKYISDIVG-FVNLEDHRVYteyCTEIEiggkS
|||||.|. | .  |.. || | |..         .|| ||    .....||| | |  ..     ||||. . ||  .....  |    |.. |     
yiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvk...Ckske....k

KDKITHRVLKVVVKaTGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALR-HPRKQNVKDSFVLLRKDR
.| . .| | |     ..| ...|..  .| .  ....  |.| |.. ||. | ||| ||  |. |  .|| |.     .     .....|    ||| |
eddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

ARSVQTFPQYVYALRCVLefLYSKGLYKRNEQEWTK------FKETYAKI
|  ...  .. ...  ..  |. .  ... ..| |.       |||| ||
alaitsalelafvdagiv..llaievldqfaeeetekkakaeeketykki

0051082 (Phosphotyrosine protein) phosphatases II 223-427 2.9e-26 87.3 In-house 5-150 (151) alignment
Range on Protein: 223-427
Range on HMM: 5-150/151.0
YIHANFVKictkpERFVCTQGPMEntctHFWQMALSLGSTSIIMLCGFVEDGseKCAKYISDIVgfvnledhrvyteycteieiggkskdkithrvlkvv
||....|      ... ...||..    .|...  .|| ..|..|.. .| |  .|..|  .                                      
yinfsyvt.....gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

vkatgqeSKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD-KKPVIAHCSAGVGRTGTLALIESMIaaLRhprkQNVKDSFVLLRKDRARSVQTFPQYVY
        .. |... .|||.|.|.| |..|..|... .. ..||. |||||.||||||...  |.  |.     .. . .  .|. |  .||.. |...
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqflf

ALRCVL
 |...|
qlfall

0049260 (Phosphotyrosine protein) phosphatases II 229-422 1.3e-33 111.2 In-house 2-142 (152) alignment
Range on Protein: 229-422
Range on HMM: 2-142/152.0
VKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIsdivgfvnledhrvyteycteieiggkskdkithrvlkvvvkatgq
.... .| .|..||||..||. .||.|  .|| | |.||. ..|.| .||..||                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

esklnHYQWASWPDHGMPDSCDTALRLLSAV----KKDKKPVIAHCSAGVGRTGTLALIESMIaalrhpRKQNVKDSFVLLRKDRARSVQTFPQYVYA
     .|..  ||||| ||. .  | || ..    .....||. ||||||||||||...  |.      .. .... . |.|. |  .|... |. . 
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 235-453 3e-24 80.5 In-house 27-241 (255) alignment
Range on Protein: 235-453
Range on HMM: 27-241/255.0
PERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS-DIVGFVNLEDHRVYteyCTEieiggkSKDKITHRVLKVVVKAT--GQESK
||. .  .     |  .|.|.    ... ..||| | |.| ||| .|.  .  .   |.|  |    .|.      |  ..  | |... . .   .  .
Pekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt...ttk......ssadvvlrtleitstlgekkktht

LNHYQWASWPDHGMPDSCDTALRLLSAVKKDkKPVIAHCSAGVGRTGTLALIES----MIAALRHPRKQNVKDSF--VLLRKDRARSVQTFPQYVYALRC
..||..  |...  |.     | .| .|..  |.|. |||.|.||. ...|.|.    || .|.     ..        ||. |.|...|  |  ...  
vkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilm

VLEFLYSKGlykRNEQEWTKFKETYAKI
||.... ||     |..... ...| . 
vldlvfpkg...eleakyqeirksylha

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 236-404 3.3e-13 44.3 In-house 5-175 (199) alignment
Range on Protein: 236-404
Range on HMM: 5-175/199.0
ERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvEDGSEKCAKYISDIVgFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHY
 |...|| |. .| . ||||    ||  |.|.    .|  .| | |       ..    .  .   |   |  |.   ||  .|   . |     .. ||
rryiatqhplretmadfwqmvwetgsghivmvn...ddqknkeadypfywp.ttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QWASWPDHGMPDSCD-----TALRLLSAVKKD--KKPVIAHCSAGVGRTGTLALIESMIAALrHPRKQNVKDSFVL
|..|| ..  |. .       | | .|   ..    ||| ||| | | || .  ..  . .     |  | | | .
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfev

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 236-404 3.3e-13 44.2 In-house 4-174 (198) alignment
Range on Protein: 236-404
Range on HMM: 4-174/198.0
ERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvEDGSEKCAKYISDIVgFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHY
 |...|| |. .| . ||||    ||  |.|.    .|  .| | |       ..    .  .   |   |  |.   ||  .|   . |     .. ||
rryiatqhplretladfwqmvwetgsghivmvn...ddqknkeadypfywp.ttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QWASWPDHGMPDSCD-----TALRLLSAVKKD--KKPVIAHCSAGVGRTGTLALIESMIAALrHPRKQNVKDSFVL
|..|| ..  |. .       | | .|   ..    ||| ||| | | || .  ..  . .     |  | | | .
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfev

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 243-433 7.1e-27 88.6 In-house 98-291 (302) alignment
Range on Protein: 243-433
Range on HMM: 98-291/302.0
GPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVnLeDHRVYTEYCTEIEIGG-KSKDKITHRVLKVVVKATGQESK----LNHYQW
 |  .|.  .| .      . .. ||.||||. .|||.| || || . |   . ||    ...    .  || . .. .| .| . ...|    ..  ..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgge.l.kfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

ASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
..||||| |.  .||| .|   .  || |. ||||||||||||  |   |    . .  .. .  . .|. |  .||.  | .| | ||   |  |
sawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek

subfamily_hpo-7_pd Subfamily hpo-7 247-451 6.9e-20 66.0 In-house 45-248 (263) alignment
Range on Protein: 247-451
Range on HMM: 45-248/263.0
NTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS-DIVGFVNLEDHRVYTEYCTEieiggkskD--KITHRVLKVVVKaTGQESKLNHYQWASWPDH
.|   |.|.    ... ..||| | |.| ||| .|   .  .   |..  | |    .        |  . |. .|... .   .  ...||..  |...
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs........dvllktlellstlge.KkkthtvkhysykgWiek

GMPDSCDTALRLLSAVKKDkKPVIAHCSAGVGRTGTLALIES----MIAALRHPRKQNVKDSFV--LLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYK
  |      |..| ....  |....|||.|.||.   ...|.    || .|.     ..    .   ||. |.|...|  |  ...  ||.|..      
ndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakg

RNEQEWTKFKETYA
  | .. . ...| 
eleakyqeirksyl

0048076 (Phosphotyrosine protein) phosphatases II 314-428 2.2e-19 65.0 In-house 30-141 (145) alignment
Range on Protein: 314-428
Range on HMM: 30-141/145.0
ITHrVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV---KKDKKPVIAHCSAGVGRTGTLALIESMIAalrhpRKQNVKDSFVLLRKDRA
||. || .    .. | .  .|.. .||||| ||. .. |..| ..    |...||. ||||||||||||...  |.      .. .. . . |.|. | 
itt.vlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrp

RSVQTFPQYVYALRCVLE
 .|... |. . ....||
gavpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 318-423 7.4e-18 60.1 In-house 33-138 (144) alignment
Range on Protein: 318-423
Range on HMM: 33-138/144.0
VLKVVVKATGQESKLN--HYQWASWPDHGMPDSCDTALRLLSAV---KKDKKPVIAHCSAGVGRTGTLALIESMIaalrhPRKQNVKDSFVLLRKDRARS
|. .. .   .. . .  .|.. .||||| ||. .  |..| ..    ....||. ||||||||||||...  |.      .. .... . |.|. |  .
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

VQTFPQYVYAL
|... |. . |
vpnpgqlrfLl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 330-432 2.5e-12 40.8 In-house 89-196 (440) alignment
Range on Protein: 330-432
Range on HMM: 89-196/440.0
SKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALR
  |..|.. .|||.|.|  .   |...  |..      . |.. |||||.|||| .  ..|..   ..  . ..      .|..| . |||  ||..   
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

CVLEFLYS
.||| | .
avlegllc

PTPc_motif_SM00404 330-423 2.8e-08 28.8 In-house 47-134 (140) alignment
Range on Protein: 330-423
Range on HMM: 47-134/140.0
SKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMiaalrHPRKQNVKDSFVLLRKDRaRSVQTFPQYVYAL
 .. ...        . .  | .|. .....|... |. || ||| |..||.. . |     . |. ...... .....|  ...   ..|. |
fqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm.....ryrqlslaeayefvkerR.piispnlnfvrqL

PTPc_DSPc_SM00012 332-428 4.8e-27 89.6 In-house 2-105 (105) alignment
Range on Protein: 332-428
Range on HMM: 2-105/105.0
LNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK------PVIAHCSAGVGRTGTLALIESMIAALRHP-RKQNVKDSFVLLRKDRARSVQTFPQYVYALR
..||.. .|||||.|...|  |.|| |||| |.      ||. |||||||||||..... ..  |..  .. .... .  ||| |...|||. ||.. .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVLE
..||
alle

0038934 (Phosphotyrosine protein) phosphatases II 334-418 2.1e-08 29.5 In-house 81-165 (194) alignment
Range on Protein: 334-418
Range on HMM: 81-165/194.0
HYQWASWPDHGMPDSCDTALRLLSAV-----KKDKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQ
.|    .||.| . | .. || |..|     .. .. |  || ||.||||||.     .|.| . .. .....  |.|  |  ....  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdy

subfamily_PTPDC1_pd Subfamily PTPDC1 334-418 4.5e-06 21.2 In-house 85-164 (182) alignment
Range on Protein: 334-418
Range on HMM: 85-164/182.0
HYQWaSWPDHGMPdSCDTALRLLSAVKK--DKKPVIAHCSAGVGRTGTLaliesMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQ
.|.. .|.|.|.. | ...| .   |.   ... |  || || |||| |     . . | . .. . ...  |.|. |..|.||  |
vynf.gwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvl.....iacylvyakrltaekaiklvrskrpksiqtreq

PTEN_1 337-419 4.6e-07 24.8 In-house 99-182 (196) alignment
Range on Protein: 337-419
Range on HMM: 99-182/196.0
WASWPDHG---MPDSCDTALRLLSAVKK--DKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDR-ARSVQTFPQY
  ...|||   .   .| . .. .....  ... |. || ||.||.||..     .| | . .| .... . |.|. | ....... | 
hfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgkltadeAlelvrekRppgapnspsqe

DSPc Dual specificity phosphatase, catalytic domain 341-410 3.5e-06 21.9 Pfam-A 51-115 (133) alignment
Range on Protein: 341-410
Range on HMM: 51-115/133.0
PDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDRA
 .  . .  . | . ........| |. || ||. |..||.     || |   .. .... . .....| 
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.....iaYlmktknlslneAyefvkerrs

DSPc Dual specificity phosphatase, catalytic domain 341-410 3.5e-06 21.9 In-house 51-115 (133) alignment
Range on Protein: 341-410
Range on HMM: 51-115/133.0
PDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDRA
 .  . .  . | . ........| |. || ||. |..||.     || |   .. .... . .....| 
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.....iaYlmktknlslneAyefvkerrs

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 357-428 5.3e-12 40.2 In-house 222-293 (297) alignment
Range on Protein: 357-428
Range on HMM: 222-293/297.0
SAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
 | .  . ... ||||||||.| . | . ..| ||. |  .|.     ||. ||| |||. |. .    ||.
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_CG42327_pd Subfamily CG42327 357-429 6.1e-11 36.6 In-house 241-314 (319) alignment
Range on Protein: 357-429
Range on HMM: 241-314/319.0
SAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHP-RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
|. .... |.. ||| ||||||..   .  |  | .. |  .. .    .|.|||..|.|  || .  . . |.
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 361-408 1.6e-07 25.0 In-house 263-310 (349) alignment
Range on Protein: 361-408
Range on HMM: 263-310/349.0
KDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKD
..  ... ||||| ||||.|  ...... |  .... .|  .  |.||
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD

subfamily_PTPN9_pd Subfamily PTPN9 363-433 3.7e-16 54.0 In-house 223-294 (297) alignment
Range on Protein: 363-433
Range on HMM: 223-294/297.0
KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL-YSK
. |.. |||||.|||||.. ..  .. |..  . .| ..  |||. || |.||  ||..   .|||.  ..|
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk