Gene ZK354.8 in Caenorhabditis elegans

Synonym: CELE_ZK354.8, CELE_ZK354.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf8
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP234_AA protein Get Run
CeleP234_AA_183-454 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 179-461 2.2e-59 195.7 In-house 2-295 (305) alignment
Range on Protein: 179-461
Range on HMM: 2-295/305.0
KKKRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFL--GNPTRNRYRNIPCCDITRVKLTD-DPHFYIHANLVSSGPNPRRFICTQAPLNGTI
||..   |  ... .|..| |||..|.         .   .|    .  .|||... | |  ||||    || ||||| ||.  ||.|||||||||. | 
kkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektc

EEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTK---IGRLCTVTKESRVDID----KTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGV
 .|| | .   .|.| |||.|.|||  | .|||.|. ... .    |.  .|  || | ..       ...   .   |  . .. |.| || .||| ||
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIG-VPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQS
|   |. . ||.  .    |||||||||.||||.. ..  ||. .   . |    ..| |.||.|  ..||. |||. |. .|.|.  || .. 
paadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkllde

0039614 (Phosphotyrosine protein) phosphatases II 180-456 1.1e-72 240.3 In-house 13-292 (297) alignment
Range on Protein: 180-456
Range on HMM: 13-292/297.0
KKRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHF-----YIHANLVSSGPN-PRRFICTQAPLNG
 ....|.  ...|  .|.  .|..|. . ..  |.   . .  | ..|||..|...| .||||.. ...     ||.|..|.     .|.||.||.||..
piplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

TIEEFWKMIIVTGIEYIVMLCELVEKGKpKSAEYFPSQIGqttKIGRLCTVTKESRVdiDKTLVMSTMRISKpgdNAVVKIVKHIHWRNWPDHGVPDNFL
|.| ||.|.   |...||||..|||.|. | |.|.|.  |   . |...  ...  .  ..  .. |.....   |  ...|.|... .|||||||... 
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppsle

SPFRLLTVVKN------CTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALK
. ...|  |..        .|..||||||||||||.......|| .     . |.  ...||| |  ||||. || . ....||.|  |
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 181-470 3.4e-158 520.1 In-house 1-288 (288) alignment
Range on Protein: 181-470
Range on HMM: 1-288/288.0
KRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWK
|..|||..|||||||..|.|||||||||||||..||..||..||||.||.|.|.||||||||.|||.|||.||.|||....||.||.||||||||||.||
kkkevinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWk

MIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVvkIVKHIHWRNWPDHGVPDNFLSPFRLLT
|......|||||||||.||||.||||||||..|....|||||||.|..|.||||....|..||||.|...|  |||..|...|.|.|||.|.|||.|||.
mllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv..ivkilhlleWdddgvPenylsplrlle

VVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKFAK
|.|...||||||.||||||||||.||||.|||..|.||.|...||||||||||.|.||||||||.||||||.|.||||...||||.|.|.
vlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlredfvklae

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 181-474 2.8e-59 195.4 In-house 1-298 (312) alignment
Range on Protein: 181-474
Range on HMM: 1-298/312.0
KRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWK
.|.|.|  |   |.      | |||.   |  ..   |.||     ||| || | |  |  |. |  ||||||.|    .| ||.|||.||. |.  ||.
qraemikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwq

MIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRlcTVTKESRVDID---KTLVMSTMRISKPGDNAVVK--IVKHIHWRNWPDHGVPDNFLSP
. .  |   |..|| .|| |  |.|.|    .|          |  |.  .|.   |.    | |. |   .|  .   ..|  |  |||||.||   . 
lalslgstsiillcgfvedgsekcakyisdivgfvdledh..rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdta

FRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK-YVQSREDFAKFAKDYEQ
.|||. ||.  ||.. |||||||||||||||  .. ..  |    |   .  || .| |.|..  ||.|| |||||.|  |  | .. ....|| . | .
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyak





0045450 (Phosphotyrosine protein) phosphatases II 182-453 1.1e-73 244.0 In-house 10-304 (307) alignment
Range on Protein: 182-453
Range on HMM: 10-304/307.0
RTEVICSWIRLVLQNGVAGLKKEYRDSPNEAP----EDIATSFLGNPTRNRYRNIPCCDITRVKLTD-----DPHFYIHANLV--------SSGPNPRRF
..........| |.....||.||... ... .    |  ..... | ..|||..|...| |||||..     ... ||.|. |        ..  ..|.|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

ICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWP
|.||.||..|.|.||.|.   |...||||.||||.|..| |.|.|.  |..  .|...  ...  .  .. ... |....  . .  . .|.|.|. .||
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPDNFLSPFRLLTVVKN------CTKPIVVHCSAGVGRTGTLALILIILESICLPDF---IGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|||||..| . ....  |..      . .|..||||||||||||.......|. .        . ..  ...||| |  |||.. || . ....||.|
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 184-459 3.3e-61 201.6 In-house 9-294 (305) alignment
Range on Protein: 184-459
Range on HMM: 9-294/305.0
EVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATS-FLG------NPTRNRYRNIPCCDITRVKLTD-DPHFYIHANLVSSGPNP-RRFICTQAPLNGT
 ..  ...  |. ||  |..|.|.  . .  |..   |        . |.|||...|| | . ||| .  |  ||||| |     | .||||.| ||. |
piveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqt

IEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKE---SRVDIDKTLVMSTMRISKPGDNAVVkiVKHIHWRNWPDHGVPDN
|.||| |.|   .| |||||  || || | |.|.|   |.  ..   . | .      .. |  . .......  ||. .   |.|..| .||| |||  
idefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkms..vrhlqwtewpdrgvppc

FLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPD-FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLaLKKYV
 |. . ||. ..    |||||||||.|||||.  |  ||| |.       .| |.  ||..|  ..|...|||. || .|.|. |.|| 
kltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf.lekyk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 184-459 1.3e-54 179.8 In-house 12-289 (290) alignment
Range on Protein: 184-459
Range on HMM: 12-289/290.0
EVICSWIRLVLQNGVAGLKKEYRDSPNEA-PE-DIA-TSFLGNP--TRNRYRNIPCCDITRVKLTDD-PHFYIHANLVSsGPNPrRFICTQAPLNGTIEE
|..  .   | . .| .| ||| .      |   .    |  |.  ..|||....| |.||| | |  .  |.||| |  | ..  || || .|. |. .
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk.Glka.mfiltqGalkdtvid

FWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLcTVTKESRVDIDKTLVMSTMRISKpGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFR
.|.|.. ... .|||||||.|.||.| ..|.| . |..  .| . ||.     | |. ... |. . .  |.   ...||.. . |||. |.   |. .|
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei.tvlcseeddkdaniikktlsvrd.kdsGkehklkhlkikswpdksvalstlallr

LLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYV
.| .... . |.|||||||.|||||.. | . |. .     . .  |   ||. |  .|| ..|||   . .|..    ||.
tlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyi

0051299 (Phosphotyrosine protein) phosphatases II 185-453 2.3e-75 249.0 In-house 9-286 (288) alignment
Range on Protein: 185-453
Range on HMM: 9-286/288.0
VICSWIRLVLQNGVAGLKKEYRDSPNEAPE--DIATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEF
 ...... .|.||..||..|... ..  |     |...  | ..|||..|...| .||||..    ... ||.|....  ...|.||.||.||..|.|.|
ellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedF

WKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPG---DNAVVKIVKHIHWRNWPDHGVPDNFLSP
|.|.   ....||||..|||.|. |.| |.|.  |.....|...  ...  |  ... .. |..... .    .  ...|.|.|. |||||||||.. . 
WrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

FRLLTVVKNC----TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
...|  |...     .|.|||||||||||||.......|| .     . |......||| |. .|||..||.. ....||||
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 185-476 1.2e-63 210.0 In-house 2-298 (307) alignment
Range on Protein: 185-476
Range on HMM: 2-298/307.0
VICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIAT-SFLGNPTRNRYRNIPCCDITRVKLTDDP--HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKM
|.  |..  |. ||  |. |.|   . .|| ... .|  |. .|||....| | .|. .. |     ||||| .    .|..|||.| ||. |. .|| |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwam

IIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLC---TVTKE--SRVDIDKT-LVMSTMRISKPGDnavVKIVKHIHWRNWPDHGVPDNFLSP
.|   .| ..|||...| .| |  .|.| . ||.   |      .|..    ..  |.  . ..|...   ..    . ..|. | ||||.|||.  |. 
aiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqk...srtiqhlqwenwpdrgvpqinlta

FRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESIC-LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLaLKKYVQSREDFAkFAKDYEQ
  ||  |.  | |.||||||||||.||.  | .. . .    .   . .|. .||..|  |.|||.|||| || .|||. |..| .. |..  ..|.||.
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf.lelyketyeell.ltknyee

AL
  
ky

0040438 (Phosphotyrosine protein) phosphatases II 186-459 1.4e-76 253.1 In-house 5-280 (317) alignment
Range on Protein: 186-459
Range on HMM: 5-280/317.0
ICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIA-TSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWK
.. .. ..|.... .|..|..| ..  ....  .... |. .|||..|...| .||||....    . ||.|..|.    .|.||.||.||..|.| ||.
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLT
|.   |...||||.||.|.|..|.|.|.|.  |.|...|...  ...  .  ..  .. |.....  ..  . .|.|.|. .|||||||... . ...| 
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

VVKNC----TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLalKKYV
 |...     .|..||||||||||||.......|| .    .. |.  ...||| |  ||||..|| . ....||||  |...
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..krkl

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 188-452 4.4e-44 145.3 In-house 16-289 (310) alignment
Range on Protein: 188-452
Range on HMM: 16-289/310.0
SWIRLVLQNGVAGLKKEYRDSPNEAPE-DIATSFLGNPTRNRYRNIPCCDITRVKLTDDP---HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMII
 .|    . |. || |.||    .        ..  .  .||| .. | | .||||. |    . ||||| | .      |||.| ||. || .||.||.
nfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmif

VTGIEYIVMLCELVEKGKPKSAEYFPSqIGQTTKIG--RLCTVTkESR-----VDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDN--FLS
    | |..||  .|.|.||.  |.|| .| |   |  |.  .. ||      ...  |.|   . . .   |     |. |.| |||| ||||.     
qeraesilllckvgeegrpkcvgywps.lgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv

PFRLLTVVKNCtkPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
| |||. |.    | |||||||..|..... . . .. .   . . .  . ..|. .|.  .|||.|||. .|  . .
pqrllaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 189-463 9.5e-51 167.7 In-house 10-291 (318) alignment
Range on Protein: 189-463
Range on HMM: 10-291/318.0
WIRLVLQNGVAGLKKEYRDS-PNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKLTDDPH----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMI
 .| . ..|   |..||    ..|.      |    | ..||| ||   | |||||..        || || .    . . .| .||||  |||.||.|.
hvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmv

IVTGIEYIVMLCELVEKGKPKSAEYFPSQigQTTKIGRLcTVTKESRVDIDKtLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVV
   .   |||| ...|.|| | . |.||.  .....|.| .|. ...|.... .|. ...... . .. ...|.  |. .|||.|||..  |   |.  |
WeqnsavivmltqeeergkakvhryWPsk..gsrsygkl.vvelkeevelsd.yvlrefkvtrteeee.srqvrqyhytsWpdegvpesgaslldlvrqv

KNCT-----KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL-KKYVQSRE
..       .||||||||||||||.   . |.|| |     . |     .|||.|   |||| || . .  .||.||  ...|....
skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasd

0043336 (Phosphotyrosine protein) phosphatases II 190-453 9.9e-70 230.5 In-house 11-277 (278) alignment
Range on Protein: 190-453
Range on HMM: 11-277/278.0
IRLVLQNGVAGLKKEYRDSPNEAPEDIA-TSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIV
.. .| |. ..|..|. . ..  ....  . .. | ..|||..|...| .||||....    . ||.|..|.  . ||.||.||.||..|.| ||.|.  
llelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwe

TGIEYIVMLCELVEKGKPKSAEYFPsqiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN
 |.. ||||.||||.|..|.|.|.|   |.....|..   ...  .  ... .. |..... ||. . ..| |.|. .|||||||... . ...| .|..
lgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavre

----CTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
    . .|..||||||||||||.......|| .    .. ..  ...||| |. ||||..|| . ....||||
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPN9_pd Subfamily PTPN9 190-455 7.9e-44 144.9 In-house 7-292 (297) alignment
Range on Protein: 190-455
Range on HMM: 7-292/297.0
IRLVLQNGVAGLKKEYRDSPNEAPEDIAT--SFLGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMII
.  | ..|  ||.||| .  ||..|  ..     .| ..||| .. | | |||.|.    |.   ||.|| |    ... || || ||. |...||.|. 
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

VTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK
   .  |||   .||.|. | ..|.|.. ..... | |   . | ..   .  ..... |..  ..   . | |     |||.|||..  | . .| .|.
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee..eedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvr

NC-----------------TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
.                    |||||||||.|||||.. . | |. .   . . |   . .||. |  ..||. || . . .||||   
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_PTPRK_pd Subfamily PTPRK 192-452 1.4e-41 137.4 In-house 15-277 (314) alignment
Range on Protein: 192-452
Range on HMM: 15-277/314.0
LVLQNGVAGLKKEYRDSPNEapEDIATSfLGNPTRNRYRNIPCCDITRVKLT---DD-PHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGI
|. ..   |.|.||   ..    | |     | ..||. .|   | .||.|.   .|    || |.|. |  .|. || || ||. |...||...   . 
llkraegygfkeeyeslfeg..wdaakk.denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydenc

EYIVMLCELVEKGKPKSAEYFPSQIGQTTKIgRLCTVtkesRVDIDKTLVMSTMRISK-PGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT
  |||| ||||.|. |  .|.| .  .  .| ..  |    ...... ||. ..|..|       ...|..... .||||.|| .  . ..|.  ||. .
asivmltelvevgrvkClkyWPedtevygdi.kvelv....etellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

K----PIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE-Y
.    .|||||||| |||||   | |.|. |   . . |     .||...   |.|| || . .  .||  
eeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileac

subfamily_PTPRD_pd Subfamily PTPRD 194-458 1.4e-59 197.2 In-house 18-286 (564) alignment
Range on Protein: 194-458
Range on HMM: 18-286/564.0
LQNGVAGLKKEYRDSPNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIE
 .|. . ...||..  ..  . . ..    |  .||| ||   | .||.|.    |.   || |. . .  ... .| ||.||. |||.||.|.    ..
kansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnss

YIVMLCELVEKGKPKSAEYFPSQiGqTTKIGRLcTVTKESRVDIDkTLVMSTMRIsKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC---
 |||| .|.|||| | ..|.|.. | |...|.| ||| |. ...  . .. |... |  ..  .. |.. |. .|||||||..  |  .|.. |...   
tiVmltkleEkgkvkchkYWPek.g.tetygel.tVtleeeeela.dyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnep

-TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKY
 ..|||||||||||||||   | ..|| |   . . .   ...||..|   |||| || . |. .||.||  . 
dagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 194-456 2e-50 166.7 In-house 18-286 (319) alignment
Range on Protein: 194-456
Range on HMM: 18-286/319.0
LQNGVAGLKKEYRDSPNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKLTDDPH----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIE
 ..|  .|.||...  .  .... ..    | ..|||.||  .| |||.|.. .      || |. . .  . ..|| |||||. |||.||.|.   .. 
astgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

YIVMLCELVEKGKPKSAEYFPSQigQTTKIGRLcTVTKESRVDIDkTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT--
 .|||..||||.| |  .|.|..  . .. ||| .|| |..   .  .... . . |  ..   . ||| .. .||||.||.. .|   ||  ... .  
ivvmltklveklkvklkkywpee..nfeeyGrl.ivtleeeeele.dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek

---KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALK
   .|||||||||||||||   . ..|| . .   . |     .||  |   ||.. || . .  .||..   
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 194-455 7.9e-48 158.0 In-house 10-278 (281) alignment
Range on Protein: 194-455
Range on HMM: 10-278/281.0
LQNGVAGLKKEYRDSPNEAPE--DIATSFLGNPTRNRYRNIPCCDITRVKLTDDPH----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGI
 ||  ||...||..  .   .    |.    | ..|||.||   | ||||.|.. .     || || |..  .....| ||.|.  ....||.|.. . .
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

EYIVMLCELVEKGKPKSAEYFPSQIgQTTKIGRLcTVTKESRVdIDKTLVMSTMRISKPGDNAvvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVV-----
. |||. . .|.|| |   |.| .  ...|.| . ||.....    .| .  ...... . ..  . |..... .|||||||..    .   . |     
saivmvtreieagklkChrYWPddn.selkygdv.tvkstaee.ekatyierkfkleresget..reveqlaytaWPdhGvPattkellefrkevlklte

KNCTKPIVVHCSAGVGRTGTLALILIILESICL-PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
|.   |.|.|||||||||||   .  .....      . |  ..|.||.||   ||| .|| . .. ||..|  
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

0036941 (Phosphotyrosine protein) phosphatases II 196-465 1.2e-79 263.1 In-house 10-289 (297) alignment
Range on Protein: 196-465
Range on HMM: 10-289/297.0
NGVAGLKKEYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
.. |.|.||... ..  .  .  ......| ..|||..|...| |||||.|... ||.|..|.    .|.||.||.||..|.|.||.|.   ... ||||
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

CELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN------CTK
.||||.|..| |.|.|. .|.. . |..   ...  |..... .. |..... |..  ...|.|.|. .|||||||... | ....  |..        .
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PIVVHCSAGVGRTGTLALILIILESIC---LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDF
|..|||||||||.||.... ..|. ..       . .. .. |||| |. ||||..||.. ....||.|  |... .  ..
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl

0050432 (Phosphotyrosine protein) phosphatases II 196-457 3e-78 258.6 In-house 39-303 (308) alignment
Range on Protein: 196-457
Range on HMM: 39-303/308.0
NGVAGLKKEYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLtDDPHFYIHANLVSSG--PNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIV
..  .|..|... ..  |  |  ....  | ..|||..|...| .|||| |... ||.|..|.     .||.||.||.||..|.| ||.|.   ....||
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIv

MLCELVEKGKPKSAEYFPSQIG-QTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC--TKP
||..|||.|..| |.|.|. .| .....|...  ...  |  ... .. |..... ||. . ..|.|.|. ||||||||... . ...|  |...   .|
mLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrkslpggp

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
||||||||||||||.......|| .     . |. ...|||| |  .|||..|||. .|..|||| ||.
ivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0047943 (Phosphotyrosine protein) phosphatases II 196-453 6.7e-74 244.1 In-house 9-272 (273) alignment
Range on Protein: 196-453
Range on HMM: 9-272/273.0
NGVAGLKKEYRDSPNEAPED--IATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
.|...|..|... ..  |.    ....  | ..|||..|...| .||||.|... ||.|..|.  . .|.||.||.||..|.|.||.|.   ....||||
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

CELVEKGKPKSAEYFPSQIGQ-TTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN------CT
.||||.|..| | |.|.  |. ... |...  ...  .  ... .. |..... |..  ...|.|.|. .|||||||... | .... .|..        
telvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsn

KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
.|.|||||||||||||.......|. .     . |. ....||. |. .|||. ||.. ....||||
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 196-451 1.1e-52 173.9 In-house 18-277 (288) alignment
Range on Protein: 196-451
Range on HMM: 18-277/288.0
NGVAGLKKEYRDSP--NEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEY
.. .|...||.  .  ..  .. |..   | ..||||||   | .||||..    .   || |. . .  . ...|.||.||  |...||...  . .. 
rnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLCELVEKGKPKSAEYFPSQiGQTTKIGRLcTVTKESRVDIDKTlVMSTMRISKPGDNavvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC----
|||| ||||.|| |  ||.|.. .. .. | . |||  .  . ... |. .. . | ...     ... ..  |||||||..    . ||. ||.     
ivmltelveggktkCeeYWPda.dkpknyGsv.tvtlveskeledf.vlrklllekkkte...leitqyqylaWpdhgvPeskapllellrqvkvanqad

TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
|.||.||||||||||||   .  ... .   |.| |   .||||..|.  |||. || . ....|.
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_PTPRG_pd Subfamily PTPRG 196-461 3.5e-42 139.4 In-house 16-295 (563) alignment
Range on Protein: 196-461
Range on HMM: 16-295/563.0
NGVAGLKKEYRDSPNEA-PEDIATSF---LGNPTRNRYRNIPCCDITRVKLTDDPH-----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTG
.|  |...|. .  .|  ..|. ...     |  .||| ||   | .||||.. |       || || .      . || || ||. |.. ||.||    
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IEYIVMLCELVEKGKPKSAEYFPSqiGQTTKIGRLCTVTKESR---VDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLspFRLLTVVK
 . |||. .|||.|. |   |.|.   .. ..| |    .|.    .   .|||.  ... |  .   .| |.. |. .|||||||.  |  . |  |.|
vaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkk

NC------TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQS
.       . |||||||||||||||.  .  .|. |   . . | ..| ..| .|   |||| ||.. |  .|| .| |.   .
ssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 196-468 4.5e-38 126.3 In-house 31-306 (319) alignment
Range on Protein: 196-468
Range on HMM: 31-306/319.0
NGVAGLKKEYRDSPNEAPEDIATSFL---GNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIE
. .  |. |.|  .. ...    .|     |  .||. ||   | ..|||      .   || |  |.   .. ..| .| ||. |...||.||    . 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

YIVMLCelvekgKPKSAEYFPSQIGQTTKIGRLCTvtkeSRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV------V
 ||.|       | | ..|.| .| .. . . .      . |.  .  |.  ...|. | .  .. ..  |.. |||.||||     .||.         
tivllt......kdkcsqywplkivikeerfkvkv....dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

KNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKF
.|  ..|||||||||||||.   . ..|. .   . . | ...  ||..| . ||  .|| . .  .||   . .   .  ||  .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 198-459 2.8e-25 83.4 In-house 25-289 (302) alignment
Range on Protein: 198-459
Range on HMM: 25-289/302.0
VAGLKKEYRDSPNE-APEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTI---EEFWKMIIVTGIEYIVML
 | .|||.    .  .. .  ..|  |. .|.  ..|. | ..|||.  | .|..|  |.     |  | .| |  ..    ||||.|.    |  .|.|
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

CELVEKGKpKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTlVMSTMRI-SKPGDNAVVKIVKHIHwrNWPDHGVPDNFLSPFRLLTVV----KNCTKP
    |  |    |.|| . |. .. |..   ..      ...  . .. .  .   |.|.  |....  ||... ||... .  .  . |     .....
vgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvlt..nWkqkkvpvkyaeliktaakvfakkikaden

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLalKKYV
.|.    |.|| |..    . .|..   .   .  .....|..| |||..  ||   ....| |.  || |
tvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi..kkkv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 199-453 2.2e-38 127.0 In-house 24-279 (315) alignment
Range on Protein: 199-453
Range on HMM: 24-279/315.0
AGLKKEYRDSPNE--APEDIATSfLGNPTRNRYRNIPCCDITRVKL---TDDPH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVM
 |.|..|   |     | |.|     |  .||| ||   | .||.|     |||  |. ||..     .||.|..|.|.  ....||...    |  |||
ngfkqdyesipggqlhpldvakk.ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivm

LCELVEKGKPKSAEYFPSQigqTTKIGRLcTVTKESRVDIDKtLVMSTMRISKpGDNavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK----NCTKP
| .|||. | |. .|.| .       |.. |||. |    .. . . |. .   |||  .. |  .|.  ||| |||   ..   |   ||    |   .
ltnlvegekrkaekywpdk...kviyGki.tvtrkseevnte.ytvrtlsvvf.gdn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvga

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
||||||||||||||.  .  .|. .   . | | ... ..|. | ..||.  || . .  .|| .
ivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 200-454 1.5e-49 163.9 In-house 28-291 (298) alignment
Range on Protein: 200-454
Range on HMM: 28-291/298.0
GLKKEYRDSPNEAP-----EDIATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYI
|...|..   .        |  ...   |  .||| .|   | .|| |..    .   || |  ...  .   || |||||. |.|.||.|..   |. |
gyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigti

VMLCELVEKGKPKSAEYFPSQigQTTKIGRLcTVTKESRVDiDKTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN----CT
||| .|.|..| |  .|.|..  .... |.. ||.  |. .    |.. .. .||   .   . |...|. .|||.||| |  | . ||. |.     . 
VmltnleeldktkyhkywPde..gketygei.tvsllskee.fadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqag

-KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
 ||..|.|||||||.||   |  .|| .     . | . .  ||..|  ||||| || . .  |||.|.
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 200-454 4e-47 155.9 In-house 23-284 (305) alignment
Range on Protein: 200-454
Range on HMM: 23-284/305.0
GLKKEYRDSPNE-APEDIATSfLGNPTRNRYRNIPCCDITRVKLTDDPHF----YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLC
||...|.  ..|  . |. ..   | ..||...|   |  |..|| ...     || |. | .  .  ..| .|.||. |...||..|. . .. ||||.
gleaqykslyeeeesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmlt

ELVEKGKPKSAEYFPSQIGQTTKIGRLcTVTKESRVDIdKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT-----KPI
.||| || |   |.| ........|.. .|. .|.  . . ...  ..||.  ..   . | . .  .|||||||.   |  .|.  |..       .|.
klveggkdkCrqYWpesktekkefgef.svelksekta.sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl

VVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
.|||||||||||.   . | || .   . . | ..| .||..|  .|||  || . |  . |.. 
lVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 200-457 4.6e-44 145.2 In-house 12-273 (281) alignment
Range on Protein: 200-457
Range on HMM: 12-273/281.0
GLKKEYRDSPNEAPEDIATSFL--GNPTRNRYRNIPCCDITRVKLTD-----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVM
 .|.|. . | . | |..| |    |  .||| |||| ||.||.|       .   ||||| . |    | .| || | . |  .||.||       |||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNavvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTKPIVVH
||...|  . | ||||| .     .. .|    ..| |  .|.|| . . .|  |.    ... |  |..|||  ||.     ...|  ..  . | |.|
lcqfletnrekcaeyfprnahcclqfdklsvsyedstv..nkslvttrlnlsyeget...rlithwlwkewpdwqvpessevmlkilrkirarstppvih

CSAGVGRTGTLALILIILESIC----LPDfigVPRLLAKLRE-ERFRAVQTEMQYLYAHRCVLEYLALKK
|||||||.|||  . | |.||     |||   . .....||   |  .|||  ||.   . .|..    |
csagvgrsgtlmaveialqsihshftlpd...ikqivshlrvtgraasvqtlqqymliwkvlldfgvayk

subfamily_Ptp69D_pd Subfamily Ptp69D 200-473 3.9e-42 139.4 In-house 23-303 (307) alignment
Range on Protein: 200-473
Range on HMM: 23-303/307.0
GLKKEYRDSP-NEAPEDIATSF-LGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
||.|||.  . .| . .  .|    |  .||| .|   | |||||.    ..   || |. . .  . ..||. |.|...||..||.||    .. ||||
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

CELVEKGKPKSAEYFP-SQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHiHWRNWPDHGVPDNFLSPFRLLTVV----KNCTKP
 .| || . | | |.|  .. |  .|   .  ...    | ..| .|..  . .  ..  |.|.. |. .|.|  ||.   . ..|.. |    |.   |
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqy.hytgWkDskvPevargllklieqvrelyklnrsP

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAlkkYVQSREDFAKFAKDYE
|||||||||||.|..  . ..|. . . | . .     .||..|   ||   || . .| .|.|     | .. ||  .... .|
ivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss...ygdtdedvddledaie

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 200-454 2e-41 136.9 In-house 6-269 (274) alignment
Range on Protein: 200-454
Range on HMM: 6-269/274.0
GLKKEYRDSPNEApEDIATSFLGNPTRNRYRNIPCCDITRVKL-----TDDPHFYIHANLVSS-GPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
 |.||. . | .  .   ..  |. |.|||..|   . .|| |     .|.   || || .   . . . .. || ||  |...||.||  . .. ||||
dlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

CELVEKGKPKSAEYFPSQIGQ--TTKIGRlCTVTKESRVDIDKTLVmSTMRISKPGDnavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC------
 .| |. . | |.||| ...   . . |    .. |. |. ..  |  .. ...  .    . |||. . .|||| .||.  . ..|.. |..       
tklkeaneqkCavyfPdaedyeiserygd.veikvekiverndysv.rklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeena

-TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
 . |.|||||||.||||    |.| .  .    .. | .. ..|| .|   |||. || . || . .|| 
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0046845 (Phosphotyrosine protein) phosphatases II 201-457 2.3e-73 242.4 In-house 2-278 (284) alignment
Range on Protein: 201-457
Range on HMM: 2-278/284.0
LKKEYRDSPNEAPE----DIATSFLGNPTRNRYRNIPCCDITRVKLTD-----DPHFYIHANLVSSG-----PNPRRFICTQAPLNGTIEEFWKMIIVTG
|..|..  ..  .       .. .. | ..|||..|.. | .||||.      . . ||.|..|.        ....||.||.||..|.|.||.|.   .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IEYIVMLCELVEKGKPKSAEYFPSQiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC-
...||||.||||.|. | | |.|.  |.. ..|...  ...  |  ... .. |..... | .  ...|.|.|. .|||||||... . ...|  |... 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----TKPIVVHCSAGVGRTGTLALILIILESICLPD---FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
      .|||||||||||||||.... ..|| .   .    . |. ....||| |. .|||..||.. ....|||| ||.
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 201-457 3.9e-43 142.3 In-house 20-280 (515) alignment
Range on Protein: 201-457
Range on HMM: 20-280/515.0
LKKEYRD--SPNEAPEDIATSFLgNPTRNRYRNIPCCDITRVKL---TDDPHF-YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLC
. .|..|   ||  |. .|   . | ..|||.||   | .||||    |.||  |. |  . |  | . .|..|.|.. ....||....   .  |.|. 
fseefhdlpgpniypqtvaqeei.nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

ELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKeSrVDIDKTLVMSTMRISKPGDnavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN----CTKPIV
.| |  | | ..|.| . |.. | | .   .  | .. .   .  .... |  |   .. |   |. .|||.||| .  | ..|.  ||      | |..
klkegdkikcgkyWPdkpgdsvkfGsikvelv.s.leactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

VHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
.|||||||||| .  |  ..  .   . . | ... ..|..|   |||. || . .  |||.|  ..
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 202-467 2.8e-42 139.7 In-house 22-291 (315) alignment
Range on Protein: 202-467
Range on HMM: 22-291/315.0
KKEYRDSPNEAPED-IATSFLGNPTRNRYRNIPCCDITRVKL---TDDPH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCEL
 .|..| |.  .    ..    | ..|||.||   | .||||    |.|.  || |  . |  . . .|..|.||. ....||.|.. . .  |||. ..
seefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkk

VEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTlvMSTMrISKPGDNavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN----CTKPIVVH
 |  | | . |.| . ..... | .   . .   | | .  .  . . . ...   . |   ....|||.||. .  | ..|.  ||      . ...||
qegdkikcrqywPdrkadsvefGsikvellsleadtdgv..arkl.vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

CSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAK
||||||||| .  |  ... |   . . | ... .||..|   |||| .| . .  |||.|  .. .     |. 
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftd

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 202-453 8.4e-32 105.6 In-house 26-288 (325) alignment
Range on Protein: 202-453
Range on HMM: 26-288/325.0
KKEYRDSPNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKL---TDDPHF-YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCEL
 .|.   |.. .    ..    |  .||..|.   | .|| |    |||.  || |. . .  .   |. .||||  ||...|....      .|.| ||
ahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel

vEKGKPKSAEYFPSQIGQTTKIGRLcTVTKESRVDIdKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDN---FLSPFRLLTVVKNC-------T
 ..|| . | |.| ..|.. . | |  |   .  .|    |.  . . .. .    . ||  ... |.| ||.     ..|  .|.  |...       .
.dlgkdrcavywpkemgksktfGgl.evklrtieei.sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
 ||.|||||||||||... .  .|. .     . .   . |||..|   |.|  ||   . .. |..
tpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

DSPc_SM00195 204-453 3.1e-71 235.1 In-house 5-262 (263) alignment
Range on Protein: 204-453
Range on HMM: 5-262/263.0
EYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELV
|.... ....  |   . .  | ..|||.||...| |||||....    . ||.|| ..   .....|.||.||. |.|.||.|.. .....||||.| .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGKPKSAEYFPSQIGQTTKIGrLCTVTKESRVDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK----PIVVHC
|.|| | ..|.|...|.....|   .|.  .    .. ... |....| |.    . |......|||||||||.  | ..|| .||....    ||||||
engkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

SAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|||||||||...| |||....  . . .  .. .||..|...|||..|||......|||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 204-453 3.1e-71 235.1 In-house 5-262 (263) alignment
Range on Protein: 204-453
Range on HMM: 5-262/263.0
EYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELV
|.... ....  |   . .  | ..|||.||...| |||||....    . ||.|| ..   .....|.||.||. |.|.||.|.. .....||||.| .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGKPKSAEYFPSQIGQTTKIGrLCTVTKESRVDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK----PIVVHC
|.|| | ..|.|...|.....|   .|.  .    .. ... |....| |.    . |......|||||||||.  | ..|| .||....    ||||||
engkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

SAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|||||||||...| |||....  . . .  .. .||..|...|||..|||......|||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 204-457 1.3e-27 91.2 In-house 25-240 (392) alignment
Range on Protein: 204-457
Range on HMM: 25-240/392.0
EYRDSPN--EAPEDIATSfLGNPTRNRYRNIPCCDITRVKL---TDDPH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELV
|..| |.    |. .|     |  .|||.||   | .||||    | |.  |. |  . |  | . .|..|.|   ....||.|.    .  |.|. .| 
efhdlpgpdiypqtvaqk.einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

EKGkpksaeyfpsqigqttkigrlctvtkesrvdidktlvmstmriskPGDNavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK----NCTKPIVVHC
|                                                ||.  .. |   |. .|||..||    | ....  ||    . |.|...||
egd.............................................kgdd..artvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc

SAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
|||||||| .  |  ..       .. |  .....|..|   |||. || . . .||| |  ..
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 210-455 1.8e-34 114.1 In-house 37-280 (287) alignment
Range on Protein: 210-455
Range on HMM: 37-280/287.0
NEAPEDIATSflgNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFP
.|   .||..   |  .||...|   |  || | .  . || |  . .  . ..|| ...|.  |. .|||.|    .. |||||.. |. . .  .|.|
devthniasq...nkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp

SQigQTTKIGRLCTVTKESRvdIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHG-VPDNFLSPFR----LLTVVKNCTKPIVVHCSAGVGRTGTLA
..  ... .|       .    . .  .. .... . . ..  . ||  .  ||...| |..   . .       |  |.   .||||||..|||.... 
ee..ksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfc

LILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
 . . ..       | | ..| . |  .  .|||  || .    |||||  
aaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 213-457 7.7e-39 128.4 In-house 25-274 (285) alignment
Range on Protein: 213-457
Range on HMM: 25-274/285.0
PEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVS-SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQ
|.   |..  ||  ||| .. | . ||| | .  . ||||. .   | .   .| || ||  |. .||.||    | |..||| |.| |  | | |.| .
pnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

IGQTTKIGRLCTVTKESRV-DIDKTLVmSTMRISKPGDN-AVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK---NCTKPIVVHCSAGVGRTGTLALI
.|.  |.|.      | .   |  |..  .. . .  |  .    ..|..   |||.  |..      |   ||      |||.|||||||||| |.  |
lgevvkfgkyeitlteckeeaiagtil.naltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgi

LIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
      |     | .  .. ..|  ||.|||. ||.|. .  ..||.  . 
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 213-452 3.1e-32 106.6 In-house 24-265 (283) alignment
Range on Protein: 213-452
Range on HMM: 24-265/283.0
PEDIATSfLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVS---SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFP
. |||..   |.. ||...|   |  ||.|  ... || |  .    |  . ...| .|.||. |. .||||.    |  |||| .| |  . | . |.|
dadiasa.denkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

SQigQTTKIGRLC-TVTKESRvDIDKTLVMSTMRISKPGDNAVVkiVKHIHWRNWPDH--GVPDNFLSPFRLLTVV--KNCTKPIVVHCSAGVGRTGTLA
..   . . | .  |. ||       .    ..| .    ....  . |    .| .   . . | |  | ..     ..   |||||||.|.|||... 
kr..GsedyGeftvtlrkett.snsfiikelllrvnssakstll..lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

LILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
 .   .. .     . |.  .  .||.|  ||||  ||   |  ||| 
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 215-346 8.1e-13 42.8 In-house 38-187 (350) alignment
Range on Protein: 215-346
Range on HMM: 38-187/350.0
D-IATSFLGNPTRNRYRNIPCCDITRVKLT------------DDPHFYIHANLVSSG-----PNPR-RFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCE
| | .. .   ..|||.||   . .||||               .  || || ..        ||  ..| |||||  |...|.|.|.  ... |..| .
DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

LVEKGKPKSAEYFPSQIGQT--TKIgrlcTVTKESRVDIDK-TLVMSTMRISKP
.|| .  |  .|..    .    |.    . ..|. ..|.. .|  . ...  .
dvelnlekcyrYWqegsydditvkl....askwenimgindsslysadvkkeas

subfamily_PTPRN_pd Subfamily PTPRN 217-451 6.6e-27 89.0 In-house 50-290 (297) alignment
Range on Protein: 217-451
Range on HMM: 50-290/297.0
ATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLV-SSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQ
...   | ..||....   | .||||..    . ..|| |  .  . |    .| ||.||. |. .||.|.   |.  ||.|..| |.|  . ..|.| .
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

IGQTTKIGRLCTVTKesRVDIDKTLVMSTMriSKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC----TKPIVVHCSAGVGRTGTLALIL
  .. .|  .  |..   .  |  || |     |  ..   . |   |.  ||..||| .  | . .   |  .    . |||||||.|.||||.  || 
Gsevyhiyevhlvse..hiwcddylvrsfy..lknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

IILESICLP-DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
..|. .      | .   | .||..|   |.|. |. .|  .| |
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

0040439 (Phosphotyrosine protein) phosphatases II 218-453 2.6e-65 215.8 In-house 6-246 (249) alignment
Range on Protein: 218-453
Range on HMM: 6-246/249.0
TSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiG
.... |. .|||..|...| .||||..     .. ||.|....    .||||.||.||..|.| ||.|.   ||..||||..|||.|. | |.|.|.  |
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..g

QTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN------CTKPIVVHCSAGVGRTGTLALIL
.....|..   ...  |   . ... |.....   .  .  |.||.. .|||||||..| . ....  |..      . .|..||||||||||||.....
gsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

IILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
..|| .     . ..  ...||. |. |||.. || . ....||.|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0045098 (Phosphotyrosine protein) phosphatases II 218-455 8.7e-64 210.9 In-house 28-274 (278) alignment
Range on Protein: 218-455
Range on HMM: 28-274/278.0
TSFLGNPTRNRYRNIPCCDITRVKltdDphfYIHANLVSSGpnPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQTTK
  .|||  .|||..|...| .|||   |   ||.|.....   |..||.||.||. |.. ||.|.   ||..||||.||||.|. | |.|.|.  |..  
alylgnldknRykdilpydhsrVk...d...YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggslt

IGRLCTVTKESRVDidKTLVMSTMRISKP---GDNAVVKIVKHIHWRNWPDHGVPDNF--LSPFRLLTVVKN-----------------CTKPIVVHCSA
.|...  ...  |   .. .. |...        .     |.|.|. .|||||||..    | ..||  ...                   .|..|||||
ygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRTGTLALILIILESIclPDFIGVPRLLAKLREERFR-AVQTEMQYLYAHRCVLEYLAL
||||||||... ..|| .  .. . ..  ...||. |   |||...|| . ....||.|  
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 218-451 2.5e-20 67.3 In-house 42-277 (303) alignment
Range on Protein: 218-451
Range on HMM: 42-277/303.0
TSFLGNPTRNRYRNIPCCDITRVKLTDDphFYIHANLVSSGPNpRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTK
  |. |  .||. .. | | ..|||.|    ||||. .    . .. | || ||. |  .||.|||   .  ...|    |  |      || .      
nqfvknmdknrfvdvicldhskvklsds..syihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

IGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIvkhIHWRNWPDHGVPDN----FLS-PFRLLTVVKNCT--KPIVVHCSAGVGRTGTLALILIIL
  |   | .  ||.. .  |.  . .|.   .. ...    |...||   .| .    |.   ..| .|... .  .| |    .|.||.||.||.    
eersirvgefkrvelgdgwvlkvlsvsngdyksflhv...hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

ESICL-PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
 |.      . . . | ..|. |. |||   |. . .  . |
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae

0042113 (Phosphotyrosine protein) phosphatases II 219-453 6e-64 211.1 In-house 5-243 (245) alignment
Range on Protein: 219-453
Range on HMM: 5-243/245.0
SFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQ
... |...|||..|...| |||||..|.    . ||.|..|.    ...||.||.||..|.| ||.|.   ||..||||.|..|.|..|.|.|.|.  |.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

TTKIGRLCTVTKESRVdiDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN-----CTKPIVVHCSAGVGRTGTLALILII
....|...  ...  .  ...... |.....   .  .. | |.|. .||||||||.  . ...|  |..       .|..||||||||||||.......
sltygdftvtllseeh..lddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|| .     . ..  ...||. |  ||||. || . ....||.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 219-453 2.4e-60 199.4 In-house 6-242 (243) alignment
Range on Protein: 219-453
Range on HMM: 6-242/243.0
SFLGNPTRNRYRNIPCCDITRVKLtDDpHFYIHANLVSSGPnprRFICTQAPLNGTIEE----FWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPsqiGQ
... | ..|||..|...| .|||| .. . ||.|||.   |   |.|.||.||..|.|.    ||.|.   ||..||||.||||.|. | |.|.|   |.
llpenlsknrysdilpydhsrvkl.eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

TtKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK------------NCTKPIVVHCSAGVGRTGT
.  .|...  ......   .  .. |.... .. . ... | |.|. .||||||||.. .  ..|  |.            .  .|..||||||||||||
v.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

LALILIILESIclpDfIGVPRLLAKLREERFR-AVQTEMQYLYAHRCVLEYL
|......|. .   . ...   ...||| |.  ||||. || . ....||.|
liaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 219-454 6.6e-43 141.6 In-house 16-265 (270) alignment
Range on Protein: 219-454
Range on HMM: 16-265/270.0
SFLGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVS-SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIG
..  ... |||..|     |||.|     |.   || || |     .....|....||. |...||.||. .  . |||. .|.|||. | . |.|.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

QTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNavVKIVkHIHWRNWPDHGVPD---NFLSPFRLLTVVKNC---------TKPIVVHCSAGVGRTG
...|.      .  .    ..  ..  .|. . |..   ..| | .. .|||||||    . ||.  ||.....          ..|..|||||||||||
ekvkledgkikvlalseekeegyiltrlrleekgee..rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

TLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
|| .. |... .     . | .....||..|   ||.  || .... |.||  
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPRA_pd Subfamily PTPRA 219-453 2.7e-41 136.5 In-house 54-295 (330) alignment
Range on Protein: 219-453
Range on HMM: 54-295/330.0
SFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQ
|   |  .||. ||   | .|| |.     .   || |  .    .  .|| .| |.. |.|.||.||       |||| || |. . | | |.|.. | 
skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.Gl

TTkIGRLCTVTKESRVDIDKTLVMSTMR-ISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILII
 |  | .    ... | .| |.    .. ...  ..  ...|. .|.. ||| ||| .    ..||  ||..      |||||||||||||||.  .  .
vt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldav

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|| .     . | . . .||  | . |||..|| . .. .||| 
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN1_pd Subfamily PTPN1 219-452 3.2e-39 129.4 In-house 28-270 (290) alignment
Range on Protein: 219-452
Range on HMM: 28-270/290.0
SFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIG-QTTK
 .  | ..||||..   | .|.|| ..   || |.||      |..| || ||  |.. ||.|.       .||| ..|||.. | |.|.|..   .. .
klpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekell

IGRLCTVTKESRVDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPD------NFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILE
.       |  . .. .. ....... .       . . | |.  ||| |||.      .||   |   ....   | |.|||||.||.||..|.  .| 
ledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

SICL---PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
 |      . . . . | .||. |.  .||  |  ...  .|| 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

subfamily_PTPN14_pd Subfamily PTPN14 219-454 1.7e-36 120.8 In-house 45-297 (300) alignment
Range on Protein: 219-454
Range on HMM: 45-297/300.0
SFLGNPTRNRYRNIPCCDITRVKLT---DDPHFYIHANLVS--SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQ--
.   |  .||....   . .||.|.   .. . || |  ..   | . | .| .|.||. |...||.|.  .|.. |||| |  |.|| || .|||..  
klpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

IGQTTKIGRLCTVTKeSRVDIDkTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDN---FLSPFRLLTVVK----------NCTKPIVVHCSAGVG
  .| . |.   .||  . | | ... .....         . | |. . .|||||||..   |||  . .  |.          .   |..||||||||
kkktvefgkfkvttk.fsedsd.svittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
||| | |  ......   . | ... ||.||| |   |||  || . .. ...|| 
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

0049772 (Phosphotyrosine protein) phosphatases II 219-455 2.2e-33 111.7 In-house 42-282 (314) alignment
Range on Protein: 219-455
Range on HMM: 42-282/314.0
SFLGNPTRNRYRNIPCCDiTRVKLtD----DPHFYIHANLVSSGpnpRRFICTQAPLNGTIEEF----------WKMII--VTGIEYIVM----------
... |...||| .|.. | .||.| .    . . ||.|. |..    ..||.||.||. |.. |          |.|..     . .|||          
dlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LCELVEKGkpksAEYFPSQIGQTTkigrlctvtkesrvdidktlvmstmrisKPG--DNAVVKIVKHIHWRNWPDHGVPdNFLSPFRLL
           |..| ..|    .|. .. . .                              .    .. . . . . .. ..||...|  .    ..|
srLdaAlgKtpllildgng....neptaadlellk............................eelydpelferlgikylripvpDgsap.lledfdefl

TVVKN--CTKPIVVHCSAGVGRTGT--LALILIILESICLPDFIGVPRLLAKlREERFRAVQTEMQYLYAHRCVLEYLAL
 ....    .|..|||.||.|||||  .| .|..|  ..| . .   ||       ....... .||.. ....||||  
efieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkf

subfamily_egg_pd Subfamily egg 219-453 7.5e-32 105.2 In-house 35-270 (307) alignment
Range on Protein: 219-453
Range on HMM: 35-270/307.0
SFLG-NPTRNRYRNIPCCDITRVKLTDDPH-F---YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKgkPKSAEYFPSQIG
..   | .. | . ..| | .||||      .   .|||| |. .|    ||..||||  | ..||.|.    ..|||||   .|    .   |.|    
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

QTTKI--GRLCTVTKESRVDIDKTLVMSTMRIskPGDNAVVKIVKHIHWrnwpDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILE
.. ..  | |   . .     |  . .. ...   | .   . ..|  .    |     .  ||.|.|  ..| .||.||..  || ...||  | | | 
dslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiall

SICLPDF--IGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|.         | |    || .|  .|.. ..||. .| || ..
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_PTPN23_pd Subfamily PTPN23 220-452 7.6e-46 151.2 In-house 40-279 (288) alignment
Range on Protein: 220-452
Range on HMM: 40-279/288.0
FLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSS-GPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKI
   ....||.|.|   | .|||| .    || |  | .  |    ||.|||||..|. .||.|.     . |||| .  |.|||| ..|.|.. |.|.| 
aklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GRLcTVTKESRVDIDkTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN--------CTKPIVVHCSAGVGRTGTLALILIIL
| | .|| .|  . . | |  .....  . .  || |.|... .||..|||.   . ...| .|..        . .|.||||||||||||..||.  ..
gdl.svtlksvrete.thvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ESIC-LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
. .   .  . ..... .|||.|   ||.. |.  .   |||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_PTPN3_pd Subfamily PTPN3 220-451 1e-45 150.9 In-house 38-273 (280) alignment
Range on Protein: 220-451
Range on HMM: 38-273/280.0
FLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNP----RRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqIGQT
   | ..||||.|   |.|||||.. .  || || |.   .      |.| || ||. | ..||.|.    .. |||| .|||.|. |  .|.|.  ...
kpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tede

TKIGRLCtVTKESRvDIDKTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILIILE
.. |..  |. |.. | .|. |.  . ...   .   . . .. . .||||||||.  . ..... |...     .|.|||||||.|||| | |. . | 
leygefs.vkceke.detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
 |   . . .. .. ..|. |   |||. || .   ..|.
lieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_PTPRB_pd Subfamily PTPRB 221-456 7.8e-57 187.5 In-house 49-288 (293) alignment
Range on Protein: 221-456
Range on HMM: 49-288/293.0
LGNPTRNRYRNIPCCDITRVKL----TDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIgQTT
  | ..|||.||   | .||||    ...   || || ..    || || || || .|...||.|.  .  . |||| .|||||| |  ||.|..  ...
avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epv

KIGRLcTVTKESRVDIDkTLVMSTMRISKpgdNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT------KPIVVHCSAGVGRTGTLALILIIL
  | . .||  .  . .   |. ...|.|   .   . |.. |.  |||||||..  .  ...  |.. .      .|||||||||||||||.  .  .|
lyGdi.kvtlvaeeele.dwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

ESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALK
..|   |.. .  ..|.|||||.  |||| ||.. |.|||..|  |
qaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 222-455 6.1e-45 148.4 In-house 8-244 (250) alignment
Range on Protein: 222-455
Range on HMM: 8-244/250.0
GNPTRNRYRNIPCCDITRVKLTDD----PHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPkSAEYFPSQigQTTK
 |  .||| .|   | .|| |  .       || |  . .  . . || ||.||. |||.||.|..   .. |||| .|.|..|    .|.| .  ...|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaek

IGRLcTVTKESRvDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC-----TKPIVVHCSAGVGRTGTLALILIILES
 | . ||.  |. ..   ... .. .||    |  .||...|. .||| |||..  . . ||. |.       ..|..|.|||||||.|.   |  .|| 
yGdv.tvsllsk.eefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

ICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
.     . | ... .||..| .||... || . .. .|..|  
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 222-468 3.8e-37 123.3 In-house 24-270 (284) alignment
Range on Protein: 222-468
Range on HMM: 24-270/284.0
GNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCelvekgKPKSAEYFPSQIGQTTK
 |  .||. .|   | ..|||      .   || |  ..   .. ..| || ||. |...||.||    .  ||.|       | | ..|.| .| .. .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

IGRLCTvtkeSRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV------VKNCTKPIVVHCSAGVGRTGTLALILIILE
 ...      . |.  .  |.  ...|. | .  .. ..  |.. |||.||||     .||.         .|  ..|||||||||||||.   . ..|.
rfkvkv....dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKF
 .   . . | ... .||..| . ||  .|| . .  .||   . .   .  ||. .
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpay

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 222-454 7.6e-35 115.2 In-house 45-284 (290) alignment
Range on Protein: 222-454
Range on HMM: 45-284/290.0
GNPTRNRYRNIPCCDITRVKLT------DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQigQT
 | ..||..||   |  |. |       | .. ||.|  .    . ...| ||.|.. |. .|||.|    .  ||||.. .|.|| |   |.|..  .|
snkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dt

TKIGRLC-TVTKESRVDidkTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHG-VPDNF--LSPFRLL--TVVKNCTKPIVVHCSAGVGRTGTLALILII
...|    ....|. ..   . .  .... .   ..  ..|.. .  ||...| |...   |. ..    |  |.  ..||||||..|||....  . . 
kaygefsikllneetln...eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaatt

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
..       | |  .| ..|  .   |||. || . .. ||.|| 
inkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 222-453 5.7e-32 105.6 In-house 37-277 (287) alignment
Range on Protein: 222-453
Range on HMM: 37-277/287.0
GNPTRNRYRNIPCCDITRVKLTDDPHF---YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQTTKI
 .  .||| ..   | ||| |. ....   || || |.|  .  .||..|.|.  |. .||.... |    ....   ||... |  .|.| .  .  ..
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GrLCTVTKESRVDIDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVV---------KNCTKPIVVHCSAGVGRTGTLALILII
|   .|.  ..   .    . ..|. .  .    ..|| ... .|||....   ..  |.   |          . . |.|||...|.||.|.|  .|..
G.GysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
..       . | . ...||| |   ||. .|. .    .  | 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

Y_phosphatase Protein-tyrosine phosphatase 223-451 2e-68 225.7 Pfam-A 1-235 (235) alignment
Range on Protein: 223-451
Range on HMM: 1-235/235.0
NPTRNRYRNIPCCDITRVKL--TDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
| ..|||..|...| |||||  ...|. ||.|| |.. .....||.||.||. |||.||.|..   ...||||..|.|||. | |.|.|.. ..... |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILIILESICLP
..  .||.  ...|  ........| ...   ..||..|. ||||||||..  | ..|.. |.. .    .|.|||||||||||||.... |.||..   
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
. . |  .. .||..|. .||.. || . ....||
eevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 223-451 2e-68 225.7 In-house 1-235 (235) alignment
Range on Protein: 223-451
Range on HMM: 1-235/235.0
NPTRNRYRNIPCCDITRVKL--TDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
| ..|||..|...| |||||  ...|. ||.|| |.. .....||.||.||. |||.||.|..   ...||||..|.|||. | |.|.|.. ..... |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILIILESICLP
..  .||.  ...|  ........| ...   ..||..|. ||||||||..  | ..|.. |.. .    .|.|||||||||||||.... |.||..   
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
. . |  .. .||..|. .||.. || . ....||
eevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_PTPN12_pd Subfamily PTPN12 223-454 1.5e-52 173.3 In-house 40-278 (290) alignment
Range on Protein: 223-454
Range on HMM: 40-278/290.0
NPTRNRYRNIPCCDITRVKLTDD----PHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKI
| ..|||..|   | .||.|. .       || ||..  . .. ..| .|.||  |...||.||. . .| .||.|..|| || | . |.|.. ......
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelef

GRLCtVTKESRVDIDKTLVMSTMRISKPgdnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILII---LE
| .. ||.|.   .|. ... |... .       ..|. .|...||||||| .. | ..|.. |..      .|.|||||||||||||.  | ..   |.
gefe.vtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellk

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
.  .|. . |  |...||..|  .|||. || . ...|.|.. 
aekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPN13_pd Subfamily PTPN13 223-454 1.3e-47 157.3 In-house 37-270 (273) alignment
Range on Protein: 223-454
Range on HMM: 37-270/273.0
NPTRNRYRNIPCCDITRVKLTDDPHfYIHANLVS--SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
| ..|||||.  .| ||||| |.   || |.|.    | .  ..| .| ||  |...||.|.     | |.|.   .|||| |   |.|.. ....|.  
nkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsn

LCTVTKESRVDIDkTLVMSTMRISKPGDNAVvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK---PIVVHCSAGVGRTGTLALILIILESICLPD
  .|...  .. | ..|.... ...   ... . | |... .||||||| . ..  .... |..  .   |||||||||.||.|||  | ..|. |    
rlevellkvqkld.gfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk

FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
 . |  .. |||| |   |||. ||.. .. .|| | 
efdvkeivrklreqrqgvvqtkdqyifvykailevlk

0041856 (Phosphotyrosine protein) phosphatases II 223-459 1.2e-44 147.4 In-house 1-177 (182) alignment
Range on Protein: 223-459
Range on HMM: 1-177/182.0
NPTRNRYRNIPCCDITRvkltddPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCelvekgkpkSAEYFPsqigqttkigrlc
| ..|||..|...| .|      .  ||.|||. ..  ..|||.||.||..|...|..|.   || .||.|.         .  |.|             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

tvtkesrvdidktlvmstmriskpgdNAVVKIVKHIHWRNWPDHGVPDnFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESiclpdFIGVP
                          . . . . .... .|||||||| . . ....  |..  .|..|||||||||||||... ....       ....
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

RLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYV
  .. .|. |. .|.|. || . ....||.| |||..
eavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_PTPN6_pd Subfamily PTPN6 223-459 9.4e-44 144.6 In-house 54-303 (306) alignment
Range on Protein: 223-459
Range on HMM: 54-303/306.0
NPTRNRYRNIPCCDITRVKLTDDPH---FYIHANLVS---SGPNpRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTT
| ..|||.||   | |||.|...      || || ..    | . ...| ||  |. |...||.|.     . |||. . ||.|| | | |.|..  ...
nkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

kIGRLcTVTKESRvDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN---C-----TKPIVVHCSAGVGRTGTLALILI
  |.. .||. |  .  .. .. ....||  ..   . | . |...||||||| .      .|. |..         . |||||||||.|||||. .| |
.yGki.svtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDi

ILESICLPD---FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYV
.|. |        | . .|  ..|| |   |||| || . .. . .|.  || .
llkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 223-457 1.8e-35 117.5 In-house 51-288 (297) alignment
Range on Protein: 223-457
Range on HMM: 51-288/297.0
NPTRNRYRNIPCCDITRVKLT---DDP-HFYIHANLVSSGPNprRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKpKSAEYFPSQiGQTTkI
|  ..||.||   |  ||||    |||   |. |  | .  .  |.|.|| | . |...||.|..   .  |||| .. |. | | | |.. . | ||  
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk.gvtt.f

GRLCtVTKESrVDIDKTLVMSTMRISKpGDNAVVKIVKHIHWRNWPDHGVPD--NFLSPFRLLTVVKN-----CTKPIVVHCSAGVGRTGTLALILIILE
| .  |. .| |.  .  .  .. ..| |.. . ..||  .. .|||. |.   .  |   |.. |..        |..|||.||||||| |  |. .. 
Gdvs.vvlls.vsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
 .   . . .  |. |||.||   |||. || . .  |||.|  ..
eakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 223-451 5.8e-28 92.7 In-house 7-238 (239) alignment
Range on Protein: 223-451
Range on HMM: 7-238/239.0
NPTRNRYRNIPCCDITRV---KLTDDPHF-YIHANLV-SSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQigqTTK
| ..||| ||   | .||   ||..|||  || |. .     .|. .|.||  .. .  .||.|.       ||||  |.|  | |  .|.|     |.|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

IGRLCTVTKESRVDIDktLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV-VK---NCTKPIVVHCSAGVGRTGTLALILIILESI
   |    ... |  |   .. |. .|. |.    . | . |.  |||.|||.   . . |     |     ..| |.||||||||||.. .|  .|   
ycnlrvtlrktevfad..yiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

CLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
     . .   .  .||.| . |||  ||.. | .|||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 223-457 6.6e-28 92.3 In-house 40-297 (301) alignment
Range on Protein: 223-457
Range on HMM: 40-297/301.0
NPTRNRYRNIPCCDITRVKLTDDPH------FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTT
| . ||..||   |  |. |.  |.       || |. ...  . ..|| .|.|.. |. .||..|.      |||...| |. | |. .|.|.   ...
nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaese

KIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVK------------HIHWRNWPDHGVPDNFLSPFRLL-----TVVKNCTKPIVVHCSAGVGR
. | . .  ... |  | ..   ...| .  .|. ..                ..  .||..||  .     . .     .  |    |.|||||..|.|
efgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsr

TGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
.|.   . | ||       . |  .   .|  .  ||.|  ||   .  . .||.|..
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 223-451 7.4e-28 92.3 In-house 8-239 (239) alignment
Range on Protein: 223-451
Range on HMM: 8-239/239.0
NPTRNRYRNIPCCDITRV---KLTDDPHF-YIHANLV-SSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQigqTTK
| ..||| ||   | .||   ||..|||  || |. .     .|. .|.||  .. .  .||.|.       ||||  |.|  | |  .|.|     |.|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

IGRLCTVTKESRVDIDktLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV-VK---NCTKPIVVHCSAGVGRTGTLALILIILESI
   |    ... |  |   .. |. .|. |.    . | . |.  |||.|||.   . . |     |     ..| |.||||||||||.. .|  .|   
ycnlrvtlrktevfad..yiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

CLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
     . .   .  .||.| . |||  ||.. | .|||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 223-452 6.2e-27 89.3 In-house 33-258 (267) alignment
Range on Protein: 223-452
Range on HMM: 33-258/267.0
NPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKgkpKSAEYFPSQIGQTTKIGRLC
|  |||. .    | ||| | .  . || |  | .    . || || ||. || .|...|.  ..  ||.|    .    .   ..| ..||. |   | 
nqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdlt

TVTKESRVDIDKTLVMSTMRISkpgdNAVVKIVKHIHWRNWPDHGVPDNFLSPF-RLLT--VVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFI
      . . |  ..   ...     |   . |   ....|        .| |.  .|.   ..|  .|.||.||.||||.||.  |   || .   .  
vehslekeendyqiitlelkfk....nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvs

GVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
 .  .| |.|. |   |.|  .|.| |. . ||
difdflrkirsqriglvdtkeryiyihellaey

subfamily_ptpA1_pd Subfamily ptpA1 223-411 5.5e-25 83.0 In-house 47-254 (418) alignment
Range on Protein: 223-411
Range on HMM: 47-254/418.0
NPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSsGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQT--T
| ..||| ||   . |||.|      .   || || .  |  |..||||| ||  || .||.|.       ||||    |. . |   |.| |||    .
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

KIGRLC-------TVTKESRVDIDKTLVMSTMRISKPGDNavvKIVKHIHWRNWPDHGVPDNfLSPFR-LLTVVKNC----------TKPIVVHCSAGVG
  |              |   | .. ..   .|..  |.    . . . ..  |||| .||    ||| ||  . |             ||.||||||||
iygngnevfgtysvelveviqdpereiitrnirltfeget...rditqyqyegwpdhnipdh.tqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTLALILIILE
||||..  .|...
rtgtfctavimmk

subfamily_eak_pd Subfamily eak 223-369 4.2e-10 33.5 In-house 52-195 (332) alignment
Range on Protein: 223-369
Range on HMM: 52-195/332.0
NPTRNRYRNIPcCDITRVKLTD---DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIG
.  || .. .|  |   |.||    ..  || | |.      |..| | .. .  .  ||.|..      ||.| | ||..  ||  ||| .  .  | |
avnrnvvkivp.ydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

RLCTVTKESrVDIdKTLVMSTMRISKpGDNAvvKIVKHIHWRNWPDHGVP
 |   .||  |   . | .  . .|| |...  . |.| .   | .  .|
ildverkef.vkr.niletrllelsk.Gnet..hrvlhykvfGwtettlp

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 224-465 1.2e-31 104.6 In-house 49-291 (439) alignment
Range on Protein: 224-465
Range on HMM: 49-291/439.0
PTRNRYRNIPCCDITRVKLTDD---PH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKpksaeYFPSQigQTTKIG
 |.|||...   | ||| | .    ||  || || .    ... .| ||.| . | ..||...|      ||||..|||  |     |.||.  . .  |
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcyg

RLcTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPD--NFLSPF-RLLTVV--KNCTKPIVVHCSAGVGRTGTLALILIILESIC
 . .|  .  ... .  .     . .   .   . | ..|.  |||. ||    ... | | .     |. . |.|||||||||||||.  . | || . 
di.avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDF
| . . .  ..  ||..| . ||.  ||.. . .||| .   .   . ..|
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 224-451 1.1e-28 95.0 In-house 4-237 (237) alignment
Range on Protein: 224-451
Range on HMM: 4-237/237.0
PTRNRYRNIPCCDITRVKLTD--DPHFYIHANLVSS-GPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQTTKIGR
  .||| || . | .|| |        || |. . .    |...|..| ||. . ..||.|.       ||||  |.|. . |  .|.||   | .  | 
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygv

LCTVTKESRVDIDKTlVmSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV-VKN-----CTKPIVVHCSAGVGRTGTLALILIILESIC
|    |      | | |  .. .|| .    |....  ..  |||.|||..  . .|.    ...      . | ..|||||||||| . .|  .|    
ltvslkkkeefsdyt.v.rslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
    . .   .  . |.|   .||. ||.. |. .||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 225-444 7.5e-49 161.1 In-house 52-272 (301) alignment
Range on Protein: 225-444
Range on HMM: 52-272/301.0
TRNRYRNIPCCDITRVKLTDDP-HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCT
 ..|| ..||   | |.. .|     |||| ...  .|.|||.||.||. | |.|| |..   .| ||||.. ||| . | .||.|..|... .|||   
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfki

VTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPR
 .|.. . ..| ..  |...    ..   . | |  . .|.|.|||      | |. .||.  ||||||||||.||. ..    ..   .     | . .
kiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptielte

LLAKLREERFRAVQTEMQYLY
 |..|||.|...|||. |  .
alkhlrehrwngvqtnsqlyw

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 225-380 8.8e-26 85.4 In-house 35-191 (297) alignment
Range on Protein: 225-380
Range on HMM: 35-191/297.0
TRNRYRNIPCCDITRVKLTDDP--HFYIHANLVS--SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
 .||||.|   | |||||   .  . || |. |     ... ..|..| ||. |...||...   ..  |||...| | |. | | |.||  ..  | | 
rknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

LCTVTKESRVDIDKTLVMSTMRISKPgdnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLT
.      |  |  ...... ...      .  . |.|. . .||||||| ..    |. .
vvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqa

subfamily_CG7180_pd Subfamily CG7180 226-453 1.3e-24 81.3 In-house 45-290 (296) alignment
Range on Protein: 226-453
Range on HMM: 45-290/296.0
RNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKpKSAEYFPSQIgqTTKIGRL
.||. ..   | .|| |.    ..   || |  | |   .. .| |.|| . |..|||...   .|. .|.|..  .  | .  .|.| .    .. | .
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygei

C--TVTKESRVDIDKTLVMSTMR-----ISKPGDNAVVKIVKHIHWRNWPD-HGVPDN---FLSPFRLLTVV-KNC-----TKPIVVHCSAGVGRTGTLA
   .|....  .. .  .  | .       . . .| ..|||..... |.  . ||     ..   |   .. ..      ..|.||..| |..|.|   
fveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyl

LILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
 | . || .   . . | . . .||..| . |..  .| |    .||..
aidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_CG42327_pd Subfamily CG42327 226-377 9.4e-15 49.1 In-house 31-185 (319) alignment
Range on Protein: 226-377
Range on HMM: 31-185/319.0
RNRYRN---IPCCDITRVKLTD-DPHFYIHANLVSSG-PNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQ-TT-KI
..|. |   .|   ..  . .| |  .|..|. |      |  .|..|..|. .  .||...       || |..| |.|  . |||.|.. .   |   
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GRLcTVTKESRVDiDKTLVMSTMRISKpGDNAVVKIVKHIHWrNWPDHGVPDNFLSPFR
| .  ||   |   ..  ..||. . .  |.   . . |  . .|.. .|| .  . . 
Gdi.lvtlkgrev.kdryaistlllkr.vdkeesrelthywy.kwleaevPaeeaalia

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 235-296 2.2e-08 28.0 In-house 58-119 (347) alignment
Range on Protein: 235-296
Range on HMM: 58-119/347.0
CDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCEL
 . ..   .||.. || |  .      . .| || ||  |. .||||. || .  .| . | 
peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 238-310 6.2e-06 20.5 In-house 8-71 (130) alignment
Range on Protein: 238-310
Range on HMM: 8-71/130.0
TRVKltddPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKgkpksAEYFPS
.|..     . ||.|..|    . . .. ||.||  |  .||||..   .. .|.|  . |.      ||.| 
srlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd

0046846 (Phosphotyrosine protein) phosphatases II 240-453 6.7e-38 125.5 In-house 5-173 (176) alignment
Range on Protein: 240-453
Range on HMM: 5-173/176.0
VKLTDDPHFYIHANLVSSGpnprRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTkigrlctvtkesrvdidktlvms
.   | .  ||.|||. ..    |.|.||.||..|...|..|.   ||...|.|.|.||.|. | . |.|   .                          
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tmriskpgdnavvkivkHIHWRNWPDHGVPDNfLSPFRLLTVVKNCT---KPIVVHCSAGVGRTGTLALILIILEsiclPDFIGVPRLLAKLREERF-RA
                 .... .||||||||     ..||  ....    .|..||||||.||||||......        .. |   ||..|| |. .|
.................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplga

VQTEMQYLYAHRCVLEYL
|||. || . ....|..|
vqtpeQyrflyefellll

0044763 (Phosphotyrosine protein) phosphatases II 241-456 2.6e-27 91.0 In-house 8-174 (178) alignment
Range on Protein: 241-456
Range on HMM: 8-174/178.0
KLTDDPH----FYIHANLVSSGpnprRFICTQAPlngtiEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGqttkigrlctvtkesrvdidktl
.|.  ..    .||.|. .  |     ..... |     .......   || .||.|.| .| |..|. .|.|.. |                       
llsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................

vmstmriskpgdnavvkivKHIHWRNWPDHGVPDNFLSPFRLLTVVK----NCTKPIVVHCSAGVGRTGTLALILIILESiclpdFIGVPRLLAKLREER
                    . .. ..||||||| .   ....  ..    .. .|..|||||||||.|||... ....       . ..  .. .|| |
...................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerR

FrAVQTEMQYLYAHRCVLEYLALK
. .|... |. . ... |..|. .
p.ivpnpgqlrqLyefelrllkes

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 243-469 1.7e-26 88.0 In-house 45-275 (290) alignment
Range on Protein: 243-469
Range on HMM: 45-275/290.0
TDDphfYIHANLVSSgPNPRRFICTQAPL-------NGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSA----EYFPSQIGQTTKIGRLcTVTKESRVD
.||   ||||| |.  ||  |.| ||.|.       | |||.|| |.    .. .|||||  || . .|     .|.| ..|.  |.. | ||   |.. 
ndd...yiHAnrvtc.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl.tvkCkskek

iDKTLVMSTMRISKpgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESIC-LPDFIGVPRLLAKLRE
 .. . . .. .    |. .   |.|   ..| .  |... ..   |.  ||. . |..|||  |. |  .|| | .    |  . . . .  .| .||.
.eddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

ERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKFA
.|  |....... ..   .. ..   .   ..|.. | |
qralaitsalelafvdagivllaievldqfaeeetekka

0043147 (Phosphotyrosine protein) phosphatases II 244-446 2.8e-36 120.2 In-house 2-154 (172) alignment
Range on Protein: 244-446
Range on HMM: 2-154/172.0
DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELvekgkpksaeyfpsqigqttkigrlctvtkesrvdidktlvmstmri
|... ||.|....    |.|||.||.||. |...||.|.   || .||.|.||                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

sKPGDNAVVKIVKHIHWRNWPDHGVPdNFLSPFRLLTVVKN-----CTKPIVVHCSAGVGRTGTLALILIILesiclpDFIGVPRLLAKLREERFRAVQT
       ... . .... .||||||| ..    ..|  ...       .|..|||||||||||||......|        . .   .| .|| |. |||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

EMQYLYAH
. || . .
psqyrfly

0036282 (Phosphotyrosine protein) phosphatases II 248-446 4.7e-36 119.5 In-house 3-163 (174) alignment
Range on Protein: 248-446
Range on HMM: 3-163/174.0
FYIHANLVSSGPNPRRFICTQAPLNgtieeFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqigqttkigrlctvtkesrvdidktlvmstmriskpG
 ||.|. ..    ..|.|..|.||.     ||.|.   ||...|||.|..|.|. |   |.|.                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................l

DNAVVKIVKHIHWRNWPDHGVPDNFLsPFRLLTVVKNC-----TKPIVVHCSAGVGRTGTLALILIILESIClPDFIGVPRLLAKLREERFRAVQTEMQY
 .  .. . .... .||||||||     ....  |...      .|..|||||||||||||......|  .. .... . .|...||  | ..|||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

LYAH
 . .
rfly

0051429 (Phosphotyrosine protein) phosphatases II 249-469 2e-42 141.1 In-house 6-239 (272) alignment
Range on Protein: 249-469
Range on HMM: 6-239/272.0
YIHANLVSSGPN---PRRFICTQAPLNGTIEEFWKMiIVTGIEYIVMLCELVEKGKPKSAEYFP----------SQIGQTTKIGRLCTVTKESRVDIDKT
||.|. |.   .   |.|......||. |...||..    || .||.|....|.|. |   | |          .   .|  .|.|.  . .  .  | .
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

LVMSTMRISKPGDNAvvKIVKHIHWRNWPDHGVPDNFlsPFRLLTVVKNcTKPIVVHCSAGVGRTGTLALILIILESICLPDFIG--------VPRLLAK
| . ....  . ..|    | |.|...|||||||..     .|| .. .  .|..||||||..||||....|..|. ..| . .         . . ...
lrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee

LREERFRAVQTEMQYLYAHRCVLEYlaLKKYVQSREDFAKFA
||. |  |||||.|||. ....||.  |... ..|... . |
lraqrpgavqteeqylflyeallel..lrsllsvraeyllaa

0051082 (Phosphotyrosine protein) phosphatases II 249-450 4.3e-28 93.2 In-house 5-150 (151) alignment
Range on Protein: 249-450
Range on HMM: 5-150/151.0
YIHANLVSSGpnprrFICTQAPLNgtieEFWKMIIVTGIEYIVMLCELVEKGkpKSAEYFPSQIgqttkigrlctvtkesrvdidktlvmstmriskpgd
||... | .|     ......||.    .|....   || .||.|....| |  . .||.|..                                     
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

navvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC-TKPIVVHCSAGVGRTGTLALILIILESiclpdfIGVPRLLAKLREERFRAVQTEMQYLYAHR
      |.||.. .|||.|.|..| .  ..| .. ..  .|..||||||.||||||......|.       . .   |. .|. |. .||...|.|. ..
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

CVL
..|
all

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 249-308 1.6e-07 25.0 In-house 92-153 (349) alignment
Range on Protein: 249-308
Range on HMM: 92-153/349.0
YIHANLVSSG--PNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYF
|| || ..       ...|.|||||  |...|.|.|.  |.. .. | .  |..  |   |.
yinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw

0049260 (Phosphotyrosine protein) phosphatases II 260-446 2.8e-33 110.1 In-house 7-143 (152) alignment
Range on Protein: 260-446
Range on HMM: 7-143/152.0
NPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFpsqigqttkigrlctvtkesrvdidktlvmstmriskpgdnavvkivkHIH
.|..||.||.|.. |...||.|.   || .||||.||.|.||.| ..|.                                                ...
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qyl

WRNWPDHGVPDNFLSPFRLLTVV----KNCTKPIVVHCSAGVGRTGTLALILIILesiclpDFIGVPRLLAKLREERFRAVQTEMQYLYAH
. .||||||||.      || ..    ..  .|..|||||||||||||......|        . .   .| .|| |  ||... |. . .
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 262-405 2.7e-12 41.3 In-house 4-153 (198) alignment
Range on Protein: 262-405
Range on HMM: 4-153/198.0
RRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRiSKPGDNAVVKIVKHIHWR
||.|.|| ||  |. .||.|.  ||  .|||. .   . .   . |.|.    |.| | |. .||   .  | |..   .  ..       . . |  . 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt.nnttappstreishyqft

NWPDHGVPDNFL-----SPFRLLTVV--KNCTKPIVVHCSAGVGRTGTLAL
 | ..  |.  |        | ..    ..   |..|||| | | || .  
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfva

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 262-405 2.9e-12 41.2 In-house 5-154 (199) alignment
Range on Protein: 262-405
Range on HMM: 5-154/199.0
RRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRiSKPGDNAVVKIVKHIHWR
||.|.|| ||  |. .||.|.  ||  .|||. .   . .   . |.|.    |.| | |. .||   .  | |..   .  ..       . . |  . 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt.nnttappstreishyqft

NWPDHGVPDNFL-----SPFRLLTVV--KNCTKPIVVHCSAGVGRTGTLAL
 | ..  |.  |        | ..    ..   |..|||| | | || .  
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfva

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 269-461 7.1e-28 91.9 In-house 98-296 (302) alignment
Range on Protein: 269-461
Range on HMM: 98-296/302.0
APLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDID-----KTLVMSTMRISKPGD-NAVVKIVKHIHWRN
 | . |.| .| .|    .  .| ||..||... | |||.  ..|.. | || .  |.. . |..     |.... |. |      ..| | |. ...  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQS
||||| |..  . . .|   .   | ..|||||||||||||  |   ..     .   .  ..  .|. |. |||.| | .|   ||   |  |. |  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekagvly

subfamily_hpo-7_pd Subfamily hpo-7 272-478 6.7e-25 82.5 In-house 44-253 (263) alignment
Range on Protein: 272-478
Range on HMM: 44-253/263.0
NGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVdidKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDN
  ||..|...|  |. | .||||.  |.|. |  .||| .  .  |.  .  .| ..     ..|. .   .|  |.   .. |||  .. |...  | .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpel

FLSPFRLLTVVKNCtKPIVVHCSAGVGRTGTLALILIILE----SICLPDFIG--VPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSRE-D
. . ...| |..|  |..|||||.|.||.   ... ..      |.   . ..    .|| .||..| ||..| ||  ..   ||...      .  |  
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleak

FAKFAKDYEQALAM
. .  | | .|  |
yqeirksylharqm

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 274-481 4.1e-26 86.6 In-house 40-247 (255) alignment
Range on Protein: 274-481
Range on HMM: 40-247/255.0
TIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKEsrvDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFL
|...|...|. |. | .||||.. |.|. |  .||| .  .  |.  .  .| .    . . ..     .|. |.    . ||| ... |...  |..  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SPFRLLTVVKNCtKPIVVHCSAGVGRTGTLALILIILE----SICLPDFI--GVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKyvQSREDFAK
    .| ||..  |..|||||.|.||. ...|. ..      |.   . .     .|| .||..| ||..| .|  ..   ||...  |.  .  ... .
eilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg..eleakyqe

FAKDYEQALAMCPK
  | | .|  |  |
irksylharqmmhk

0048076 (Phosphotyrosine protein) phosphatases II 345-452 1.2e-20 69.1 In-house 37-142 (145) alignment
Range on Protein: 345-452
Range on HMM: 37-142/145.0
KPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC---TKPIVVHCSAGVGRTGTLALILIILEsiclpDFIGVPRLLAKLREERFRAVQTEMQ
 .  . ... . .... .|||||||| .    ..|  ....    .|..|||||||||||||... ..|.       . ..  |...|. |. ||... |
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YLYAHRCVLEY
. . ....||.
lrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 346-447 9.2e-20 66.3 In-house 48-139 (144) alignment
Range on Protein: 346-447
Range on HMM: 48-139/144.0
PgdnavvkiVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC---TKPIVVHCSAGVGRTGTLALILIILesicLPDfIGVPRLLAKLREERFRAVQTEMQY
.        . .... .|||||||| .    ..|  ....    .|..|||||||||||||... ...    . . . .   || .|. |. ||... |.
e........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgql

LYAHR
 . ..
rfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 353-461 9.1e-14 45.6 In-house 89-202 (440) alignment
Range on Protein: 353-461
Range on HMM: 89-202/440.0
KIVKHIHWRNWPDHGVPDNFLSPFRLLTVV-----KNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHR
. .|. |.. |||.|||      ....  |     |    |..||||||.|||| .  .  ||      | | .  ..  .|..| . |||  || . | 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

CVLEYLALKKYVQS
.||| |     .  
avlegllcgdtlil

0038934 (Phosphotyrosine protein) phosphatases II 354-409 1.2e-08 30.4 In-house 78-138 (194) alignment
Range on Protein: 354-409
Range on HMM: 78-138/194.0
IVKHIHWRNWPDHGVPDNFLSPFRLLTVV-----KNCTKPIVVHCSAGVGRTGTLALILII
   ...   .||.|.. ..   .| | .|     ..  . ..||| ||.||||||.   .|
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLi

PTPc_DSPc_SM00012 355-451 4.3e-29 96.2 In-house 2-105 (105) alignment
Range on Protein: 355-451
Range on HMM: 2-105/105.0
VKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK------PIVVHCSAGVGRTGTLALILIILESICLP-DFIGVPRLLAKLREERFRAVQTEMQYLYAHR
|||.|. .|||||||..  | ..||  ||....      |.|||||||||||||.... |.|....   ... . ... .||..| ..||||.|||. .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVLE
..||
alle

0048567 (Phosphotyrosine protein) phosphatases II 358-404 4.8e-06 21.0 In-house 40-95 (157) alignment
Range on Protein: 358-404
Range on HMM: 40-95/157.0
IHWRNWPDHGvPDNFLSPFRLLT-------VVKNCTKPIVVHCSAGV---GRTGTLA
...  . |.| | |    .|. .       ..... |.|.|||.||    |||.||.
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLi

PTEN_1 359-405 1.3e-07 26.6 In-house 98-149 (196) alignment
Range on Protein: 359-405
Range on HMM: 98-149/196.0
HWRNWPDHGVPDNFLSPFRLLTVVKNC-----TKPIVVHCSAGVGRTGTLAL
. . ..|||.|.       .  .   .      . ..||| ||.||.||.. 
lhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_CDKN3_pd Subfamily CDKN3 359-447 6.6e-06 19.8 In-house 103-190 (202) alignment
Range on Protein: 359-447
Range on HMM: 103-190/202.0
HWRNWPDHGVPDN--FLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIIlesiCLPDFIGVPRLLAKLREER-FRAVQTEMQYLYAHR
|    .| .|||    |  .  |..  .  .  .|||  |.||.  ..  |..     | |.|     ..|||. .  ||.||  || | . 
hhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclll....ylddtiepkdaidklrdlkgsraiqtvkqynylse

subfamily_PTPDC1_pd Subfamily PTPDC1 362-443 3.3e-06 21.7 In-house 89-166 (182) alignment
Range on Protein: 362-443
Range on HMM: 89-166/182.0
NWPDHGVP--DNFLSPFRLLTVVKNCTkPIVVHCSAGVGRTGTLALILIILESIclpdfIGVPRLLAKLREERFRAVQTEMQYL
 |.|.||.  .. |   .... . .    . ||| || |||| |    ..  .      .   . . ..|..| ...||  |  
gwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqve

subfamily_CDC14_pd Subfamily CDC14 377-408 1.3e-06 22.5 In-house 254-285 (328) alignment
Range on Protein: 377-408
Range on HMM: 254-285/328.0
RLLTVVKNCTKPIVVHCSAGVGRTGTLALILI
..|.......  |.||| ||.||||||    .
kfleiaekaeGaiavhCkaGLGrtGtLiacyl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 384-457 1.8e-07 25.2 In-house 260-348 (350) alignment
Range on Protein: 384-457
Range on HMM: 260-348/350.0
NCTKPIVVHCSAGVGRTGTLALILIILESI-----CLPDF----------IGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
. ..||.|||||||||||||  .  .|. .        ..            .  .. .||. | . ||.  |... . ..| | ||.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLrk

subfamily_CG42327_pd Subfamily CG42327 385-453 1.9e-11 38.2 In-house 246-315 (319) alignment
Range on Protein: 385-453
Range on HMM: 246-315/319.0
CTKPIVVHCSAGVGRTGTLALILIILESICLP-DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
   |.||||| ||||||..    | ..|.  .   . .|.|.  .|..| .||.|  || . .. . || 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 385-457 8.5e-07 22.8 In-house 270-342 (347) alignment
Range on Protein: 385-457
Range on HMM: 270-342/347.0
CTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
   |.|| |  |. |. |. |  ||.| .       .  |. |.|..|       . | || |. | || || 
klapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylklkl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 385-457 7e-06 19.6 In-house 264-348 (349) alignment
Range on Protein: 385-457
Range on HMM: 264-348/349.0
CTKPIVVHCSAGVGRTGTLALILIILE--SICLPDF--IGVPR--------LLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
 . ...|||||| ||||.|  . ..|.  .    ..  | ..          . .||  |.  ||   |.   . ..|.|.||||
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 387-451 1.5e-09 32.2 In-house 229-293 (297) alignment
Range on Protein: 387-451
Range on HMM: 229-293/297.0
KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
 ...|||||||||.| . |  .||. .       |  .| .|||.| | |||  |. . .  ||.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 389-457 2.9e-07 24.8 In-house 1-69 (69) alignment
Range on Protein: 389-457
Range on HMM: 1-69/69.0
IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
.|||||.| |||||.  |.. .  |    .. .   .  .|  |   |  |..|.. |  . | | | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 390-457 1.4e-06 22.6 In-house 1-68 (69) alignment
Range on Protein: 390-457
Range on HMM: 1-68/69.0
VVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
|||||.| |||||.  |.. .  |    .. .   .  .|  |   |  | .|.. |  . | | | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk