Gene ZK484.7 in Caenorhabditis elegans

Synonym: CELE_ZK484.7, ZK484.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP237_AA protein Get Run
CeleP237_AA_37-319 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 28-322 6.3e-77 254.2 In-house 19-303 (308) alignment
Range on Protein: 28-322
Range on HMM: 19-303/308.0
GTTAEKKTHRKQIVKFVKNalEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhpPWPHDYIHANFVSTP--SNPRRFICTQ
 ..  .|.. ....|....   ... .|..|| .. .. . .......  . . ||||||. ..||.||||  . ..|||.|..|...   .||.||.||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq

APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDK-PVLEFEekghKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYH
.||.....||| |. ...|  | ||....|.| .||. |.  . .  .||..    |. |.. |. .       .. .| ......   .|   .||..|
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfh

WIDWPDRGVPTADMAIVELLAKTRPS--KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
...||| |||.   .....| . | |  .||.|||||||.|||| .......|.||  . .     ....|.||||....|| .||||.....| |...|
ytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

K
.
l

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 32-335 2.8e-194 638.7 In-house 1-304 (305) alignment
Range on Protein: 32-335
Range on HMM: 1-304/305.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKS
|||...|||.||||..||||||||||||.|||||||||||||||||||.||||||||||||.|||||..||||.|||||.||||.||.|||||||||.|.
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt

CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG
||||||||||.||..||||||..|||||||..|||.|||.||||||||.||.|||||....||.|...||.||||...||||. |.|||.||||||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLA
||.||.||.|||.|.||||||.||||||||||||||||.||||||||.||.||.|||||||||||||||||||.||||||||||||...||..|..|| |
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea

HLAF
. ||
ykaf

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 32-322 1.2e-75 248.9 In-house 4-293 (305) alignment
Range on Protein: 32-322
Range on HMM: 4-293/305.0
EKKTHRkQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMK-AFKEAQ----EHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNP-RRFICTQ
  .||   . .||. ||. |   || ||  . ..   .  . ||.  |    .  ||||.|| | |.. |||. | | ||||||.|  |  | .||||.|
ppqthp.iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaq

APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFeeKGhKIIVKFEStGKMKFEKntDAKITETVFTVEGPGGLAQKVTQYHWI
 |||..  .||.| .|.||. | |||. .| |  ||..|.       ||.  |.  |.|.  | |   .|.  ||.|  |.. .   |.    | . .| 
gpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel..ks.givvenvs.gskpmer..daeiqitllnltysgdqkmsvrhlqwt

DWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.||||||| . .. .|||.  | || | ||||||||||||..| |||||...   ..     .... .|.||  |||.| ||||.|.|.||| |.| 
ewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky

subfamily_PTPRB_pd Subfamily PTPRB 32-322 4.9e-57 188.2 In-house 4-289 (293) alignment
Range on Protein: 32-322
Range on HMM: 4-289/293.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPL
.|... ... ..||.  ..  ...  |.  .| ..  ...|| ..|... ||||...   ||.||||   .     ||| ||...  . || || || ||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

DKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVlefeEKGhKIIVKFESTGKMKfekntdaKITETVFTVEGpGGLAQKVTQYHWIDWP
 ..  ||| |....|.  | || ...||| .|| .|.  ...||      | .| |.. .. ...       . .   ...|  .   .||.|||.. ||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv....lyG.dikvtlvaeeele.......dwvirelkiek.ekeerkvrqyhftsWp

DRGVPTADMAIVELLAKTR------PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| ||| .  ...... . |       ||.|.|||||||.||||  . .. .|...   . .. .  |....||.||. .|| .||.|.||..|... .|.
dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdif.givaelReeRnllvqtekqYifihqcvldllrkke





subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 32-317 1.3e-51 170.7 In-house 6-289 (298) alignment
Range on Protein: 32-317
Range on HMM: 6-289/298.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFND---FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQ
|... .... |...   .|. .|. .||  ... ..    |.... .. . . |||| |.  ||. || |.        ||| | |... ..   || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEFEEKGHkIIVkfestgkMKFEKNTDAKITETVFTVEGP-GGLAQKVTQYHW
||| .. .||| |  .|.. .| || |. |..  |.  |.     |  . |. |. | |          .|.. |... . ..|.       ..| | |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkyw.....Pdegketyge.itv.......sllskeefadlivrklkvskkkeekerevrqlhf

IDWPDRGVPTADMAIVELLAKTRPS---KG--PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNY
. |||.|||.   ....||.| | |    |  | .|.||||.||.|. . |. .|...   | ..   .... .|..| ...|| .|| |.....|..
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvD.vfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 33-166 1.6e-17 58.3 In-house 8-151 (350) alignment
Range on Protein: 33-166
Range on HMM: 8-151/350.0
KKTHRKQIvkFVKNALEKGPAGLRAEFAamKRFNDFEKMKAfkeAQEHGKNRYKDVGCLDHNRVKLH-----------PPWPHDYIHANFVSTP-----S
|... | |  . ||.  | .  | ..       ||..  .     .   |||||..   .|.||||.              . ||| ||... .      
krsklkli..itknstvksrlsLesdse..spsnDvilseG...velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsvei

NPR-RFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
||  ..| ||||| .   ||. ..|. ||  | .| . .| . .||  |. 
npdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq

0051299 (Phosphotyrosine protein) phosphatases II 35-318 9.1e-76 250.4 In-house 5-286 (288) alignment
Range on Protein: 35-318
Range on HMM: 5-286/288.0
THRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKS
 . ....|.|.. | .|..||..|| .. ...   ...|..  . . ||||.|. ..||.||||... .   .|||.|...... ..|.||.||.||...
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-----PGGLAQKVTQYHWID
..||| |. ...|  | ||....|.| .||. |.    . .|....    | |.. |. .       ....| ....|.      ..|  ..||..|...
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytn

WPDRGVPTADMAIVELLAKTRPS----KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
||| |||.   .....| . | .    .||.|||||||.|||| .......|.||. . .  .  ......||||....|| .||.||....| |.
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 35-320 2.2e-72 239.7 In-house 9-306 (307) alignment
Range on Protein: 35-320
Range on HMM: 9-306/307.0
THRKQIVKFVKNALEKGPAGLRAEFAAMKRFND--FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFV--------STPSNPRR
  .......|.  | ....||..||  ......    ......  . . ||||||. ..||.||||... .    .|||.|..|        ... ..|.
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG--PGGLAQK
||.||.||.....||| |. ...|  | ||.. .|.| .||. |.  . . .|....    . |.. |. .       ....| ....|.   . |   .
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrt

VTQYHWIDWPDRGVPTADMAIVELLAKTRP------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQI--EETDKILQKIREQRNNSIQTDQQYLFV
||..|...||| |||.    ..... . |       ..||..||||||.||||..... ..|.||  .. .     .......|||| ...|. .|| |.
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

HQVILNYCLD
....| ..|.
yeallelllk

subfamily_PTPRD_pd Subfamily PTPRD 36-318 4.3e-61 202.2 In-house 6-281 (564) alignment
Range on Protein: 36-318
Range on HMM: 6-281/564.0
HRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAqEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSC
. ... ..|..   .. . .  |.  ... . |.. .| |.|    ||||...   ||.||.|..       ||| |.|. .  ... .| ||.|| ...
pvaelkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

ADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEfEEKGHKIIVKFESTGKMKFEKNTDAKITETVftvegpGGLAQKVTQYHWIDWPDRGV
.||| |. .... .| || .. ||| .|| .|.     |  . .|.  ...|..|.. ...    .. |....          ...|.|.|...|||.||
edFWRmvweqnsstiVmltkleEkgkvkchkYW.....Pekg.tetygeltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgv

PTADMAIVELLAKTR----PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|.   ....|. | |    | .||.|||||||.||||  . |...|...   ....   ......|.|||  .|| .|| |.|..||.. 
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvD.iyqyvkalrkqRnamVqteeQYiFiheaileal

subfamily_PTPN6_pd Subfamily PTPN6 36-320 1.8e-50 166.7 In-house 9-299 (306) alignment
Range on Protein: 36-320
Range on HMM: 9-299/306.0
HRKQIVKFVKNALEKGPAGLRAEFAAMKRF---NDFEKMKAFKeAQEHGKNRYKDVGCLDHNRVKL-HPPWPH-DYIHANFVS--TPSNPRRFICTQAPL
 .... .. |.  ... ||.  || ....    . ...... | .. . ||||| .   ||.||.| .|  |  ||| ||...  .... ...| ||  |
ieqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl

DKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKGHKIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWP
..  .||| | .||.   | |. . .|.| .||. |.  . .     || |.  . . ...      ...| .. | . . .  .. ...| |||. .||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek....eeyGkisvtnvsek......sladYilRelsvskkkkkkeerevfqyhfksWP

DRGVPTADMAIVELLAK----TRP----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLG--GQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
| |||.   |....| .    ..     ..||.||||||||||||....|. .|...     .   .  |. ...||||.  .||.||| ||...| .| 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

LD
  
et

0043336 (Phosphotyrosine protein) phosphatases II 37-318 9.4e-71 233.8 In-house 4-277 (278) alignment
Range on Protein: 37-318
Range on HMM: 4-277/278.0
RKQIVKFVKNALEKGPAGLRAEFAAMKRFNDfEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCA
.|...|.... | .....|..||  . .|.  . .. ..  . . ||||||. ..||.||||..     ..|||.|..|.... ||.||.||.||.....
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGV
||| |. ...| .| ||.. .|.| .||. |.    . .|....    . |.. .. .       .. .| ....|.    |  ..||.||...||| ||
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgv

PTADMAIVELLAKTRP----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|.    ....| . |     |.||..||||||.|||| .......|.||  .. .   .......|||| ...||..|| |.....| |.
peslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl

subfamily_PTPN14_pd Subfamily PTPN14 37-318 2.5e-39 130.1 In-house 9-296 (300) alignment
Range on Protein: 37-318
Range on HMM: 9-296/300.0
RKQIVKFVKNALEKGPagLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW--PHDYIHANFVSTP--SNPRRFICTQAPLDKSC
. . .| ... ||.|   . .|.  ... .   .... |  ..  |||.|||   ..|||.| |     ..|| |  ....  .. | .| .|.||.. .
kdkrakilekkleegk..vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltv

ADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIvkfestgkMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGV
 ||| |  ...|. | || .. |.| .|.  ||  ...   . | . .|..         || ...|. || ..     | .  ..|    ..||||.||
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvt........tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgv

PTADMAIVELLAKT----------R---PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|      .. | .           .    || | .||||||.|||| ... . ..  |  ...|.  .|.|...||||   .||  || ||..|...| 
PeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 38-324 4.3e-64 210.9 In-house 12-289 (290) alignment
Range on Protein: 38-324
Range on HMM: 12-289/290.0
KQIVKFVKNALEKGPAGLRAEFA-AMKRF--NDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPrrFICTQAPLDKSCAD
. . ||  .. .|.. .|  |.   .| .   .. . | | .  |  ||||||| | |  || |.   . ||.|||.|     .  || || .| ..  |
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkam..filtqGalkdtvid

FWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghKIIVKFEstgkmkfEKNTDAKITETVFTVE-GPGGLAQKVTQYHWIDWPDRGVP
.| | |||||  | |||...|.|  || .|.  |.  || | |     ..  |       |.. ||.|   ...|     |   |.  .. . |||. |.
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe...itvlcse.......eddkdaniikktlsvrdkdsGkehklkhlkikswpdksva

TADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKIlQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMF
 ...|.. .|   |   || ||||||||||||. | ||  |. || |....  | . . .|. | ||.| | ||| . ...|..  | | .
lstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlv.ralrnsrlnsvqvdiqylalveilldlGkdfkyi

subfamily_PTPRG_pd Subfamily PTPRG 38-327 1.8e-49 163.4 In-house 4-296 (563) alignment
Range on Protein: 38-327
Range on HMM: 4-296/563.0
KQIVKFVKNALEKGPAGLRAEFAAMKR--FNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSNPRRFICTQAPLDKS
|. .| | .   .|  |. .|| |...   ..  .... .. ... |||| ..   |. ||||.|       .||| ||..      . || || || . 
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkDKPvlefeEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG
. ||| |  ...|  | |. |. |.|..||  |.   |..     |.  .. |. ... ..        .| ..    .      ..|.|||. .||| |
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.des.....etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVD
||.  .  .    |    ..   ||.|||||||.||||  .... .| |.   ... .  ..|..|| |||. .||  ||.|.|...|.  . |.   ..
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraqRnflvqteEqYiflhdalleaiasketella





subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 38-318 3.3e-43 142.7 In-house 5-278 (287) alignment
Range on Protein: 38-318
Range on HMM: 5-278/287.0
KQIVKFVKNALEKGPAGLRAEFAAMKRFNDFE-KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
... .||..  .||  | .  |. ... .. | ..      | . |||....   | .|| |.    .||| | |. . .. ..|| ...|. .   .||
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfW

YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvLEFEEkgHKIIVKFEStgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG-VPTA
 .  ...|  | |||. .|.  ..| .|.. ..   . . |  ..| .  |        .|..  . .   . ..  |  |.|.||.  .|...| |.. 
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe..yniellnee.......vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep

--DMAIVELLAKT--RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
   . ..|   ||  ...... |||||...||..  . ..  ...      |.   ..|.. | |. .|.|| .|| |. ...|.| 
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleyl

0040438 (Phosphotyrosine protein) phosphatases II 39-331 5.1e-76 251.3 In-house 4-289 (317) alignment
Range on Protein: 39-331
Range on HMM: 4-289/317.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFeKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADF
.......  | ..  .|. ||  . ...    .. ..  . ..||||.|. ..||.||||.|. .   .|||.|..|..|. .|.||.||.||.....||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPVLEFeekgHKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPT
| |. ...| .| ||.. .|.| .||. |.    . .|..    ....|.. |. .       .| || ....||.  ..   .||..|...||| ||| 
wrmvweqgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp

ADMAIVELLAKTRPS----KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKL
    ....| . | .    .||..||||||.||||........|.||  ....   .......||||....|| .|| |.....|.|.. | ..  . .|
spdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel

A
.
k

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 39-318 4e-51 169.0 In-house 8-283 (305) alignment
Range on Protein: 39-318
Range on HMM: 8-283/305.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFekMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADF
.. ...|.|  .   || |.. .. . ..   ..  |. ... |||.|..  ||..|..| .   .   ||| |..| . ..  ..| .|.||..  |||
dlaayikearvysdkgleaqykslyeeees..idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf

WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFeeKGHKIIVKFESTGKMKFEKNTDAKITETvftvegpGGLAQKVTQYHWIDWPDRGVPTA
|.. ..||| .| ||....| | .||  |.. . . . ||     ....| |.| .  .|..  . | ..           . |.||.  |||| |||. 
WrliveekvstivmltklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiede.......dkesrtvlqyqltdWPdhGvpqf

DMAIVELLAK----TRPSKG-PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
  ....|. .     . .|| | .||||||.||||  ....  |..|   ....   ..|...|..| . .|| .|| |.|... .. 
atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvd.vfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 39-323 1.3e-50 167.1 In-house 5-276 (288) alignment
Range on Protein: 39-323
Range on HMM: 5-276/288.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFkeAQEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
 |  ...  |. . .||  |.      .  . ...|   ..  ..||... . |  ||||.   |. ||.|| ||.  ..||.||.||||.     .| |
vinawirlvlqiaveglkkeyrdspneasidiidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

CLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKghkiivkfESTGKMKFeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMA
 |.. |. | |||...||| .|  .||  |      .            .  | |  .. |  .. ... .. .|  .. | . |. .|.| |||   ..
llesdveyivmlcellekGkeksaeyfPsklGekarigrl........ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenyls

IVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKM
 . ||   .  . | |||.|||.|||| ...|  .|..|   .      ..|.| ||.| ..||| .|||.||...|.. | || 
plrllevlkslqkPivvhssaGvGrtgtlililialeslrl.ddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 39-318 3.1e-46 152.5 In-house 6-283 (290) alignment
Range on Protein: 39-318
Range on HMM: 6-283/290.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH-----DYIHANFVSTPSNPRRFICTQAPLDKSCA
.  .|| |   ||  | |..| ... ..  ....     ... .||....   | ||. |.|   |     .||.| ..   .. ...| ||.|. .  .
kfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVleFEEKGHKIivkfestgkmKFEKNTDaKITETVFTVEGPG--GLAQKVTQYHWIDWPDRG
||| .  ||||  | ||.||.|.| .||  |.. .|     ..|   |.            |.... ...|. . |.     | .|.||||.   |.. |
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikl..........lneetln.eyierklevknknsagakqsvtqyqitnwdstg

----VPTADMAIVELLA-KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
      |  ..| |    . .. ... |||||...||..  . ..  ...    ..|.   ..|.. | |. .|.|| ||| ...|..|.| 
kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvid.vfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_PTPN9_pd Subfamily PTPN9 39-248 9e-36 118.4 In-house 2-204 (297) alignment
Range on Protein: 39-248
Range on HMM: 2-204/297.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADF
.| ..|.   |||  ||. |.|.... .   ...|.|   .  ||||.|| |.|. ||.|         |||.||||    ... || || ||.| . ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKfestgKMKFEKNTDakITETVFTVE-GPGGLAQKVTQYHWIDWPDRGVPT
| |  ...|  | |   ..|.|  ||  |.  ... . || .    . |.     ... |.. |   ...|....    .  .||| .  . ||| ||| 
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgd....lsvs.....nveveeeed..ykvrvleiknvkteesrkvthfqflsWPdyGvPs

ADMAIVELLAKTRP
. ......| | | 
saaslldvlekvre

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 39-321 6.6e-28 92.0 In-house 15-288 (302) alignment
Range on Protein: 39-321
Range on HMM: 15-288/302.0
QIVKFVKNaleKGPAGLRAEFAAMKRF-NDFEKMKAFKEAQEhgKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSC---AD
. .|.||.      | ...|| ... .  | || ||||.  .  ||. .|| .||.|.|||.   | .|..|  |. |.  |  | .| |  .|    ..
eakklvks...ldtaevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvkle.aepdsyvnaskvevPeltrsiilaQlpkvdsedsvee

FWYMCLQEKVDSIFMLcnIMEKGAKKCCDYFACKDKPvlEFEEKGhKIIVKfestgKMKFEKNTDAKiteTVFTVE-GPGGLAQKV--TQYHWIDWPDRG
|| |  |||. |...|  ..|.  ||  . . .|     ...| | |. |      . | ||  ..|   | ...|  | | .. |  . |.   |..  
FWrmvfqekivsvvil..vgeeelkktlselfpkksg..dykeyg.kmfvN.....nrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkk

VPTADMAIVELL----AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
||.   ....      ||. ... .||.    |.|| |...     ...|  |..  .   |...||.|| ..... .|| ... ..| | . |
vpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkep.nikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 40-317 4e-53 175.4 In-house 8-278 (288) alignment
Range on Protein: 40-317
Range on HMM: 8-278/288.0
IVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
 |. |...  .. .|.  |. ..  ..  .. .| ..|. . ||||...  .|..||||.        ||| |...    . ...|.||.|| ..  |||
pvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLeFeekGHkIIVKfestgkMKFEKNTDAKITETVFTVegPGGLAQKVTQYHWIDWPDRGVPTAD
 .  ..|.  | || ...|.| .|| .|.  .|||.. .   |. . |.      .. .|...  .....  .    .   ..|||..  ||| ||| . 
elvyenktstivmltelveggktkCeeYWPdadkpkn.y...Gs.vtvt......lveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPesk

MAIVELLAK---TRPSK-GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNY
. ..||| .   . ... || .||||||.||||  . .. ..|..   ..|. .. ...|.|.||.. .|| .|| |...|.|. 
apllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevllsl

subfamily_PTPRN_pd Subfamily PTPRN 40-167 1.4e-15 51.8 In-house 17-148 (297) alignment
Range on Protein: 40-167
Range on HMM: 17-148/297.0
IVKFVKNALEKgPAGLRAEFAAMKRFNDFEKMK-AFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTpSNPRR--FICTQAPLDKSCA
....... |.. .  |..|. |.....  .. | . |. .   |||.|.|   ||.||||.       .||| | ..   ..||.  .| ||.|| .. |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastva

DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAC
||| |  .. |  | .|... |.| |.|  |.  
dfwqmvweqGvvvivnltrleeegvkqckrywpd

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 41-319 8.8e-51 167.8 In-house 8-281 (318) alignment
Range on Protein: 41-319
Range on HMM: 8-281/318.0
VKFVKNALEKGPAGLRAEFAAMKRF-NDFEKMKAfKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
 . |..  |.|   | .|. ...|  . . ..|.  |   . |||| ..   || ||||..       ||| ||..    . . .| .|||| . . |||
eshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfW

YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvLEFEekghKIIVKFESTGKMKFEKNTDAKITETvftvegPGGLAQKVTQYHWIDWPDRGVPTAD
 |  . .   | || ...|.| .|.  |.  |.    ...    |. |. ... ...       |.|.|           ..| |||. .|||.|||.  
rmvWeqnsavivmltqeeergkakvhryWPskgs..rsyg....klvvelkeevelsdyvlrefkvtrt......eeeesrqvrqyhytsWpdegvpesg

MAIVELLAKTR-----PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
. ...|. ...     ...||.|||||||.||||  .... .|...   . ..   .. ...|||||  .||..|| |...|.|..  
aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 41-341 1.1e-44 147.5 In-house 7-298 (312) alignment
Range on Protein: 41-341
Range on HMM: 7-298/312.0
VKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEhgKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCL
 |.    .   |  |  |. |.       .  ||   ..   ||| .. | |  |  |       |||||||   ..| ||.|||.||...|. || ..|
kkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlal

QEKVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFEEkgHKiiVKFESTGKMKFEKNTDAKITETVFTV-EGPGGLAQKVTQYHWIDWPDRGVPTADMAI
     || .|| ..| |..||. | .      ...|.  |.  |  |.  ...   ..  |||  |. |     |   |. .| |  ||| |.| .  . 
slgstsiillcgfvedgsekcakyisdi.vgfvdled..hr..vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdta

VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKlAHLAFTEKY
  ||.  .  | | . |||||.||||....|| ..  |   .. .   ...  .| .|  |...  ||... ...|..   | ..  . .  .  | | |
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqn.vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneq.ewtkfkety

MK
 |
ak

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 42-341 1.1e-74 246.2 In-house 5-300 (307) alignment
Range on Protein: 42-341
Range on HMM: 5-300/307.0
KFVKNALEKGPAGLRAEFAAMKRFNDF-EKMKAFKEAQEhgKNRYKDVGCLDHNRVKLH-PPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMC
 .|...|.||   |. ||  . . .     ..||.  ..  ||||.|| | |..|. .. .    ||||||.. .  .|..|||.| ||...  .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama

LQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEkntDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAI
.||||.|. |||...| .  || .|.  ..   | | |... | |.   ..|.  .   .  |  | . |.  .. .. .... | .|||||||  ... 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapd...edlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinlta

VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAHLAFTEKY
..||  .|  . | |||||||.||.|..| | .. |... |.   . .|.....|.||. .|||. |||..|.|.|.| |..     .  |    . |||
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeeky

MK
 |
ak

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 42-318 2.2e-52 172.9 In-house 4-276 (281) alignment
Range on Protein: 42-318
Range on HMM: 4-276/281.0
KFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
| .|.  ..  ||.  |.....  .  .  .| |. .   ||||...   |. |||..|       ||| ||||.. ......| ||.|. .|...|| |
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

CLQEKVDSIFMLCNIMEKGAKKCCDYFAcKDKPvlefEEKGHKIIVKFEStgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMA
 ...||. | |. . .|.|  ||  |.   |.     | |  ...||...       ... |.  | .|..|  .| ...|.| ... ||| |||.  ..
vweqkvsaivmvtreieagklkChrYWP.ddns....elkygdvtvksta.......eeekatyierkfkleresgetreveqlaytaWPdhGvPattke

IVELLAKT----R-PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..|  ..     .  .| | |.|||||.||||. . .. .....   ..  . . .....|..||  .||  || ||....|.. 
llefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 42-333 1.8e-51 170.1 In-house 12-295 (319) alignment
Range on Protein: 42-333
Range on HMM: 12-295/319.0
KFVKNALEKGPAGLRAEFAAMKRFNDFeKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
. .|.  ..|  .|. ||  .|  ... ...  .. . . ||||...   |. ||.| .       ||| |.|. .  . ..|| |||||..   ||| |
erlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

CLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEFEEKGhKIIVKFESTGKMKFEKNTDAKITETVFTVEGpgglaQKVTQYHWIDWPDRGVPTADMA
  .|..  . ||... ||.  |.  |.     |  .||| | ..||. |.  ...     . |. .    ||       .|..... .||| .||.  ..
vWeeessivvmltklveklkvklkkyw.....peenfeeyG.rlivtleeeeeledyiirklklnkkssevet.....RevkhfqyteWpdhdvPekats

IVELLAK-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCldkKMFDVDVKLAHL
...|| .      ....|| |||||||.||||. .... .|...   . ..   .. ...| |||  .|. .|| |.....|..    ...| .... .|
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlD.vfstvsrlRtqRnimvqrpeqYkfiyealleav...eagdteievqdl





subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 43-316 1.4e-40 134.2 In-house 14-277 (315) alignment
Range on Protein: 43-316
Range on HMM: 14-277/315.0
FVKNALEKGPAGLRAEFAAMKRfNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMC
.| .       |.. .. ..    ..  ..  |. ... |||| ..   |. ||.|         ||. |||.   . .||.|..|.|.  |  ||| . 
yvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv

LQEKVDSIFMLCNIMEKGAKKCCDYFACKdkpvlefeekgHKIIVKFESTgKMKFEKNTDAKItETVFTVEgpGGLAQKVTQYHWIDWPDRGVPTADMAI
 .|..  | || |..|.  .|.  |.  |           . |  |.  | ... |.||.  .  |. .|   |   ..| |.|.  ||| |||   ...
feedigkivmltnlvegekrkaekywpdk...........kviyGkitvt.rkseevnteytv.rtlsvvf..gdnirevvqlhytswpdmgvpkytipl

VELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILN
..|  .       | |. |||||||.||||. . .. .|||.   . |.   ......|..| . .|. .|| |.....|.
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalle

subfamily_PTPN3_pd Subfamily PTPN3 44-317 2.9e-51 169.0 In-house 8-274 (280) alignment
Range on Protein: 44-317
Range on HMM: 8-274/280.0
VKNALEKGPagLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPhDYIHANFVSTPSNP----RRFICTQAPLDKSCADFWYMC
.|..||.|   . |.|  . | .   ...| . ...  ||||.|.   |. ||||.     ||| ||.|.  ..      |.| || ||.|...|||.| 
lkeglesGa..vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmv

LQEKVDSIFMLCNIMEKGAKKCCDYFACKDkPVLEFEekghKIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAI
 ..|.  | || ...|.| .||. |.  ..   ||.     .. || |..      ..| . ..  .   .      .|..|  ...||| |||.    .
weqksslivmlttlverGrvkChqyWPete.deleyg....efsvkceke......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadf

VELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNY
.|.. . |  .     |.|||||||||||| ....|  |  .   ...   | |....|.|| . .|| .|| || . ||. 
lefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypld.ivrtmrdqramlvqtasqykfvCeailkv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 44-165 3.2e-11 37.1 In-house 18-153 (349) alignment
Range on Protein: 44-165
Range on HMM: 18-153/349.0
VKNALEKGPAGLRAEFAamKRFNDFEKMKAfkeAQEHGKNRYKDVGCLDHNRVKLH-----------------PPWPHDYIHANFVSTP--SNPRRFICT
 |..  | .  | ..       .|..  .     .   ||||||.   .| ||||.                    ..||| ||... .  |  ...|.|
tkysksksmlslesddd..seiddvilseG...velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiat

QAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYF
||||  .  ||. . | ..|  .. | .  |.. .||  |.
qaPlPstvddfykvillngvklvlsLnddkelslekcdiyw

subfamily_Ptp69D_pd Subfamily Ptp69D 45-320 5.4e-49 162.0 In-house 14-288 (307) alignment
Range on Protein: 45-320
Range on HMM: 14-288/307.0
KNALEKGPAGLRAEFAAMKRFnDFEKMKAFKEAQE-HGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCL
|.  ..   ||  |.  ...   ..|   . | .|   ||||.|.   |..||||..   .   ||| |.|. .  . ..||. |.|..    ||| |  
ksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia

QEKVDSIFMLCNIMEKGAKKCCDYFACKdkPVLEFEekghKIIVKFESTGKMKFEKNTDAKITETVFTVeGPGGLAQKVTQYHWIDWPDRGVPTADMAIV
. .|  | || |. ||  |||  |..       ...    .|.||. |. |..   . . .....  .. |     .||.|||.  |.|  || .  ...
eqevtlivmlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvPevargll

ELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.|. .     . ...| ||||||| ||.| .| .. .|.||   ....   .. ...|.|||  .|  .|| |... .|.|   
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif.etvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_PTPN23_pd Subfamily PTPN23 45-318 5.5e-43 141.8 In-house 7-280 (288) alignment
Range on Protein: 45-318
Range on HMM: 7-280/288.0
KNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEA--QEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVS--TPSNPrRFICTQAPLDKSCADFWYMCL
...  .| ..| ..|. ... .| |  |    .      |||..|.   |||||||.     ||| | ||   .|  |  ||.|||||... .||| |  
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvy

QEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkiivkfeSTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIV
..|.  | || .  |.| .|.  |.  .     .|..           .  .| ...|.  .  ..     .    ..|.  ..  ||. ||| .   ..
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetll

ELLA--------KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..|         . |.|| | |||||||.|||| . ..  .. .|  |. . .. ......|||| ...|. .|. |. ...|.. 
qfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 48-322 2.7e-35 117.1 In-house 18-292 (325) alignment
Range on Protein: 48-322
Range on HMM: 18-292/325.0
LEKGPAGLRAEFAAMKRFNDFEKMKAFKeAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKv
  .   |.  ||  .   .   |  | |  ..  |||.|.|  ||..|| |         ||| |... .  .   |. .|||| ..  |.| . |. . 
kaqdqdgfahefgllpsddgiakkvamk.penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.

DSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMkfeknTDakITETVFTVEGP-GGLAQKVTQYHWIDWPDRGVPTADM---AIV
 |. .. |....| ..|. |.  .     .|      . ||. .  ..     .|      |. | .. .| .. | |...  |.| ||.       .|.
csvvvvlneldlgkdrcavywpkemgksktfG....glevklrtieei.....sd..yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

ELLA-------KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.|.            . .| .||||||.||||  . .  .|....   ...   . ..|.|..| . ..|  || .... . .. .  .
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdif.gfvkklrkdrpsmvetvdqyiliyealveaymsgn

0039614 (Phosphotyrosine protein) phosphatases II 50-321 2.8e-70 232.5 In-house 29-292 (297) alignment
Range on Protein: 50-321
Range on HMM: 29-292/297.0
KGPAGLRAEFAAMKRFNDfEkMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSN-PRRFICTQAPLDKSCADFWYMCLQEKV
... .|..||  ...... . .. ..  .   ||||||. ..||.||||.|.      .|||.|..|....  .|.||.||.||.....||| |. ...|
nsktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

DSIFMLCNIMEKGAkKCCDYFACKDKpvlefeeKGHKIIVKFESTGKmkfekntDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAIVELLA
 .| ||.. .|.|  ||..|.  .         . ... |.. .. .       .. .| ....|.  .|   .||......||| |||     . |.| 
tvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslelllefle

KTRP------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
. |       ..||..||||||.||||..... ..|.||  ....   .......||||....||..|| |.....| ... |
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk

0047943 (Phosphotyrosine protein) phosphatases II 51-318 1.7e-71 236.2 In-house 10-272 (273) alignment
Range on Protein: 51-318
Range on HMM: 10-272/273.0
GPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFML
|...|..|| ..... .  ......  . . ||||||. ..||.|||| .. ..|||.|..|...  .|.||.||.||.....||| |. ...|  | ||
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

CNIMEKGAKKCCDYFACKDKP-VLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP
....|.| .||. |.  .    .|....    ..|.. |. .       .. .| ......    |   .||..|. .||| |||.    ..|.. . | 
telvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
      |.||.|||||||.||||........||||  ....   .......|.|| ...|| .||.|.....|.|.
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 51-319 1.1e-38 128.3 In-house 32-292 (319) alignment
Range on Protein: 51-319
Range on HMM: 32-292/319.0
GPAGLRAEFAAM-KRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDS
    |..|| .. |.  .  ...     |.  |||. ..   |.|.|||..       ||| | ||.   .. ..| .| ||| . |||| |  . .. .
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IFMLCnimekgAKKCCDYFACKdkpvleFEEKGHKIIVKFESTGKMKFekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK-
| .|        .||..|.  |       ..|  .  || .|  . .        . .   . .|     .|.||.|.  ||| |||   . .. |. | 
ivllt......kdkcsqywplk......ivikeerfkvkvdsveetae.....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv

-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
         . . |||||||.||||  .... .||..   .|..   .... .|.|||. .|   || |..  .|.  |
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalleehl

0036941 (Phosphotyrosine protein) phosphatases II 52-333 6.5e-77 254.1 In-house 12-292 (297) alignment
Range on Protein: 52-333
Range on HMM: 12-292/297.0
PAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
.|.|. ||  . ..    ......  .   ||||||. ..||.|||| .. ..|||.|..|.... .|.||.||.||.....||| |.....| .| ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NIMEKGAKKCCDYFACKDKPVLEFeekgHKIIVKFESTGKMkfeknTDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP--
. .|.| .||. |.  .   .|..    ....|.. |. ..     ... .| ....|.   .|   .||..|...||| |||.    ..... . |   
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLG--GQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAHL
    |.||..||||||.||.|........|.|| .   ..     ....|.||||....|| .||.|.....|.... |...  ..||..|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 53-321 3.8e-34 112.7 In-house 20-239 (392) alignment
Range on Protein: 53-321
Range on HMM: 20-239/392.0
AGLRAEFAAMKRFNDFEKMKAFKEaQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
| .  ||  .   . ...  | ||  .  |||||..  .| .||||        .||. | .. .  | . .|..|.|   |  ||| | .||.| .| |
alffeefhdlpgpdiypqtvaqke.inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

LCNIMEKGakkccdyfackdkpvlefeekghkiivkfestgkmkfekntdakitetvftvegPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS
. .. |                                                         |  |. |.|.|. .|||..||    ...... . .  
vtklkegd......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad

KG----PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
 |    | ..|||||.|||| |. |. .. .    . . .  ... .||..|   .||..|| |..  .|.  | .
fGqythpliihcsagvgrtgvvisidsvvahakktrmv.dvfnfvtnirrkrpymvqtkeqyafiygavledllwr

0046845 (Phosphotyrosine protein) phosphatases II 54-322 1.5e-73 242.9 In-house 1-278 (284) alignment
Range on Protein: 54-322
Range on HMM: 1-278/284.0
GLRAEFAAMKRFNDFE--KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTP-----SNPRRFICTQAPLDKSCADFWYMCLQE
||..|| .. ... .   ......  . . ||||||. ..||.||||... .    .|||.|..|...      ....||.||.||.....||| |....
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFeekgHKIIVKFESTGKmkfekNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVEL
.|  | ||....|.| .||. |.  . . ||..    ....|.. |. .     . | ....   | .|..|   .||..|...|||.|||.    ..|.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef

LAKTRPS------KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQ--IEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| . | .      .||.|||||||.|||| .......|.||  ...       ......||||....|| .||.||....|.|.. |.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

subfamily_PTPN12_pd Subfamily PTPN12 54-319 9.3e-55 180.5 In-house 16-278 (290) alignment
Range on Protein: 54-319
Range on HMM: 16-278/290.0
GLRAEFAAMKRFNDFEKMKAfKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFML
 |... ...|. . ... .. .. ..  ||||||.   |..||.|.    .   ||| |||.  .... ..| .|.|| |   ||| |  . .|  . |.
klkklsekykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvma

CNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKFEStgkmkfEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
|...| | |||  |.. . .  |||.|    . |. |.      ||..|  ..   ..||   .  .||.|.|. .|||.|||..   ..||... |   
CrevelgkkkCerYWpeegeeelefge....fevtlee......ekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelq

---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD--KILQKIREQRNNSIQTDQQYLFVHQVILNYCL
   . | |||||||.|||| .. |.|. ..|  ..  || |  ......|.||.  .|| .|| .|.. ..... 
esedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

DSPc_SM00195 55-318 4.4e-74 244.5 In-house 2-262 (263) alignment
Range on Protein: 55-318
Range on HMM: 2-262/263.0
LRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
|..||  ... .  ....  .. ... |||||.. . ||.||||...    ..|||.||...........|.||.||.. ..||| |...|||  | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntdAKITETVFTVEGPGG-LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
. .|.| .|| .|.  . .   .|.    || ||. .. |.|      ..|. ......  |   ..|||||.. .|||.|||   . ..||| . . | 
eeeengkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
   .||.|||||||.||||..|.|..||..|  .... . ..|....|.|| ...||..||||....||.|.
stssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 55-318 4.4e-74 244.5 In-house 2-262 (263) alignment
Range on Protein: 55-318
Range on HMM: 2-262/263.0
LRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
|..||  ... .  ....  .. ... |||||.. . ||.||||...    ..|||.||...........|.||.||.. ..||| |...|||  | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntdAKITETVFTVEGPGG-LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
. .|.| .|| .|.  . .   .|.    || ||. .. |.|      ..|. ......  |   ..|||||.. .|||.|||   . ..||| . . | 
eeeengkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
   .||.|||||||.||||..|.|..||..|  .... . ..|....|.|| ...||..||||....||.|.
stssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 55-318 5.9e-43 141.9 In-house 7-268 (274) alignment
Range on Protein: 55-318
Range on HMM: 7-268/274.0
LRAEFAAMKRFNDFEKMKAFKeaqEHGKNRYKDVGCLDHNRVKLHPPWPH----DYIHANFVSTPSN-PRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
|..||  .    | |... |.   .. |||||..   .. || |..  ..    .|| ||..  ...  . .. || || .  |||| |  ||.|. | |
lekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

LCNIMEKGAKKCCDYFAckDKPVLEFEEKGHKIIVKFESTgkmkfEKNTDAKITETVFTVEGPgglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS
| .. |.  .||  ||   |.  .| .|.  .. .|.|..      .. | .... |          ..|. | . ||||. .|    ....|..... |
ltklkeaneqkCavyfP..daedyeiserygdveikveki.....verndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvlevees

-------KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
        .|.||||||||||||  . |.  . ||   . ..   ||  ..| .|   .||..|| ..|...  | 
reeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclyl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 55-318 1.2e-35 117.6 In-house 17-293 (301) alignment
Range on Protein: 55-318
Range on HMM: 17-293/301.0
LRAEFAAMKRFNDFEKMKAFKEaQEHGKNRYKDVGCLDHNRVKLHPPWP-----HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
. ... ..|. .| . .  ..| ...  ||.|..  .|.||. |.|        ..|| |....  |. ..|| .|.|..|  .||| . .|||. || |
feeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LCNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKFEST----------GKMKFEKNTDAKITETVFTVEGPGgLAQKVTQYHWIDWPDRGV---P-TA
..|  |.  .||  |.   ..   || .    . |.. ..           ..| .. .. . .|  | |.     ...|.|.. .|||. ||   | | 
vtnlkegtkskceqywpnseaeseefgp....ftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtv

DMAIVEL-LAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
 ..| .   .. ....|| |||||....|.|  . ..  |.|    . . .  .. . .| ..   ..| .|| ....||  | 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 55-318 2.2e-24 80.9 In-house 8-259 (267) alignment
Range on Protein: 55-318
Range on HMM: 8-259/267.0
LRAEFAAMKRFNDFEKM-KAFKEAQEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
.. ||  .|.  | .     .   . . .||. |.   |..|| |     ..|| | .| .    . || || ||... .||. .  ..||  | .| ..
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

MEKGAKKccdYFackdKPVLEFEEKGHKIIVKFeStgkMKFEKNTDAKI-TETVFTVEGpgglAQKVTQYHWIDWPDRGVPTAD-MAIVELLAKTRPSKG
 .   ..   ..     | .   .| . . |.. |   .. |.|    |  |  |  |     |..|| |..  |            .. .||| .  .|
ftdnirl...fw....PPkmgqakkyqdltveh.s...lekeendyqiitlelkfknes....ahnvtlyyykkwnintnnkpylkplfgilaknqleng

--PTVVHCSAGIGRTGSVVMIEYILDQLLgGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
  | ||.||.|.||.|. ..|.  |...   ... .  . |.|||.||   ..| ..|...|... .| 
nrPlvvacsdGvGrsGtflvidsqlerak.tegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_PTPN13_pd Subfamily PTPN13 56-316 5.3e-47 155.4 In-house 14-267 (273) alignment
Range on Protein: 56-316
Range on HMM: 14-267/273.0
RAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPhdYIHANFVSTPSNPRR--FICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
  ||  .. .   .. .  |..... ||||..|   |. ||||    .  || |...  | .  .  .| .| || ....||| |  . |.. | |. . 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

MEKGAKKCCDYFACKDKPVLEFEEKghkIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTR---PSK
 |||  ||  |.  . .  |  ...   . |. . .      .. |.    ..   .   | ...|.. ....||| |||.. . .....|. |    ..
kekgkvkchrywPesknkklkvsnr...levellkv......qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILN
|| ||||||||||.|... |. .|. .   ....   .|..|.||||.  .||..||.||...||.
gPivvhcsaGiGrsGtlitidvvlglierdkefd.vkeivrklreqrqgvvqtkdqyifvykaile

subfamily_PTPRA_pd Subfamily PTPRA 56-326 9.8e-44 144.6 In-house 35-304 (330) alignment
Range on Protein: 56-326
Range on HMM: 35-304/330.0
RAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCN
| || |.   .    ... .. ... |||. ..   |..|| | .       ||| | |.    .  .|| .| |....  ||| |  . |  .| || .
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte

IMEKGAKKCCDYFAckDKPVLEFEEkghkIIVKFESTGKMKFEKNTDAKITetVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP----
. |.  .||  |.   |. .. . .    | |. | .  ..     .  ..    . .     .. |.|.|.  ||| |||.  . ...||.| .     
lkerkeekcaqywP..deGlvtyGn....irvevedetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq

SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK-MFDV
| || |||||||.||||. .... .|...   ....   ......| || . .|||.|| |...|.|.| |     .||
sagpivvhcsaGvGrtGtfivldavlervkaerkvd.vfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 56-318 1.3e-34 114.4 In-house 13-277 (287) alignment
Range on Protein: 56-318
Range on HMM: 13-277/287.0
RAEFAAMKRFNdfEKM-KAFKEAQE---HGKNRYKDVGCLDHNRVKL--HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
 .|. |.|.    | .   ||.|.|     |||| ||  .|..|| |  ..    ||| ||.|..  .  .||..|.|.  .  ||| . |.... |. .
dkevdalkeds..esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LCNIMEKGAKKCCDYFACKDKPVLEFeekGHKIiVKFESTgkmkfEKNTDaKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIV----EL---
.   .|.. .||  |.  ...|..     |. . | .. .      |. .   . ..  ..  .  |. | |.....|||.... . ....    .    
mtreveearlkcykywPerevPmrvG...Gysv.vlldyd.....ikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqh

--LAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
  ||.     || |||...||||.| .. .  ....|.   ... . ... ..||.|.  .|.  |. .. . .  | 
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 58-322 9.2e-45 147.5 In-house 16-273 (281) alignment
Range on Protein: 58-322
Range on HMM: 16-273/281.0
EFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
||. .      .   .|..  .  |||| .. |||  ||.|.   |     ||||||.. .|   | .| || |  .. |||| |  ||.  .| |||..
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

MEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntDAKITETVFTVEGPgglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPT
.|   .||..||  . . .|.|.    |. |..| .   |         |   .. ||    .. .|.. | .|||  || .   ....| | |    | 
letnrekcaeyfprnahcclqfd....klsvsyedstvnk.....slvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkirarstpp

VVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIRE-QRNNSIQTDQQYLFVHQVILNYCLDKK
|.|||||.||.|... .|  |. .     . .  .|. ..|   |  |.|| |||... .|.|.. .  |
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk

subfamily_eak_pd Subfamily eak 64-323 1.6e-14 48.1 In-house 34-310 (332) alignment
Range on Protein: 64-323
Range on HMM: 34-310/332.0
RFNDFEKMKAFKEAQEH---GKNRYKDVgCLDHNRVKLHPPW--PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGA
 ..|...... .|..      .| .| |   |.. |.| .    .  || |  .  .   |..| | .. ..    || | |..|  .| .| . .|.. 
dlddyqrllsisetarleavnrnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

KKCCDYFACKDKPVLEFEEK--GHKIIVKFESTGKMKFEKNTDAKIT-ETVFTVEGPGGLAQKVTQYHW-I--DWPDRGVPTADMA-------IVELLAK
.|   ||  | . .|.|       |  || .     ..| .   .      ..| |   ..  . .    .     . ||.            ..    .
eksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyih

TRPSKGPtVVHCSAGIGRTGSVVMIEyILDQLLGGQQIE--ETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKM
| ||  | .. .. |  |.|  |.|. .| .|. ... .    .... |....|. |. ...|. |.....|.| | .. 
tppsfap.iiqsarGsaraGvfvvid.llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn

subfamily_egg_pd Subfamily egg 66-320 3.4e-33 109.6 In-house 27-272 (307) alignment
Range on Protein: 66-320
Range on HMM: 27-272/307.0
NDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgaKKCC
 | . ..   .. .  | | | | | |  ||||. .   .  |.|||| |.       ||..||||  .  ||| |  ||.|. | ||    |   ..| 
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

DYFACKDKPVLEFEEKGHKIivkfestGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWiDWPDRGVPTadmAIVELLAKTRPSKGPTVVHCSAGIG
 |.   ..  | .   . .|         .| ....|   . | . . |.    . .  . . |.   .        ...| | |    |.||..  |. 
yywpkaesdslvtvpGslri.......enlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvy...splrvlrklrnlskpvvvqdilGvs

RTGSVVMIEYILDQLLGGQQIE-ETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.....| ||  | .|| |        .  . .| .|. |...  .||||....| .  |
kaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_PTPN1_pd Subfamily PTPN1 67-316 2.8e-50 165.7 In-house 21-269 (290) alignment
Range on Protein: 67-316
Range on HMM: 21-269/290.0
DFEKmKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
||.  .. |. .....|||.||   || |.||.     ||| |..|  .   |..| || || . .. || |  ..|  .. || ...||.  || .|. 
dfpt.reaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

CKDK-PVLEFEEKGHKIivKFESTGKMKFEKNTDAKITEtvftveGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS------KGPTVVHCSA
....   |..|.   |.  |. |. . .. .    ....           .......|.. ||| ||| .  | ...| | | |      .||.|.||||
qgeeekellledtklkv..kliseerksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GIGRTGSVVMIEYILDQLLGGQQI--EETDKILQKIREQRNNSIQTDQQYLFVHQVILN
||||.|...... .| ..   ...   .  | | ..|..|   ||| .|  | .. ||.
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRK_pd Subfamily PTPRK 68-320 1.2e-47 157.3 In-house 32-279 (314) alignment
Range on Protein: 68-320
Range on HMM: 32-279/314.0
FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY
||   | |. ... |||..|.   |. ||.|..       ||| |... .  .|. || || ||..  .||| . ..|.  || || ...|.|. ||. |
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

FACKDKpvLeFeekgHKIIVKFestgkmkFEKNTDAKITETVFTVEG---PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHC
.  . .    .     .| |..        | ...|..   .|.||    .    ..| |.... ||| .||.   ....|...    . ...|..||||
WPedte..v.y....gdikvel.......vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

SAGIGRTGSVVMIEYILDqLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
||| ||||  ..|. .|| ..  ... .  .. ...|... | ..| .|| |...|||. || 
saGaGrtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 68-322 4.2e-42 139.1 In-house 33-281 (315) alignment
Range on Protein: 68-322
Range on HMM: 33-281/315.0
FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY
  . .. .| ... |||||..  ||..||||        .||| | .. .  . . .|..|.||. |  ||| | ||||| .| |. .  |    ||  |
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

FACKDKPVLEFEEkghkIIVKfestgKMKFEKNTDAKITETvftVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG----PTVVHCSAG
.  ..    || .    | |.      .. | .||. . .    |   .   ..|||... .|||.||.    ....|. . . ..|    . .||||||
wPdrkadsvefGs....ikve.....llsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaG

IGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.|||| |. |. ...|.  .. ..   ......|..|   .||...| |.....|.. | ..
vGrtGvvisidevvaqikrtrsvd.vfnfvknlrakrpylvqteeeyafiydavledllwrn

subfamily_CG7180_pd Subfamily CG7180 70-320 2.2e-26 87.2 In-house 33-292 (296) alignment
Range on Protein: 70-320
Range on HMM: 33-292/296.0
KMKAFKEAQEHGKNRYKDVGCLDHNRVK---LHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAkKCCDYFA
. ..  ...  .|||. .|   |.|||    |.     ||| | .| .   .. .| |.|| ...  .|| .  .|..... .|.. ..    .. .|. 
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

CKDkpvlefEEKGHKIIVKFESTGKMKFEKNTDAKITETVF-TVE---GPGGLAQKVTQYHWIDWPD-RGVPTADMAIVELLAK-------T--RPSKGP
 |       .|.  .|.|.  .. ..   |    |.| ..  . |   .       |.....  |.    ||    |..||. .       .  .| .||
nks......keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

TVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.||..| | .|.|  . |.  |...   ....   . ....|..|.. ... ..| .. .|.|.. | 
vvvvssdGasRsGvylaidanlelvekeeevdvF.eavktlrrsRpqLvenveeYkyiYdvlleavlc

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 70-156 1.1e-08 29.0 In-house 87-174 (244) alignment
Range on Protein: 70-156
Range on HMM: 87-174/244.0
KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP-PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEK
 ||   . ..  |||      .| ||| |        || | ||        .| || ||  .  ||| | |. .|. . .|  . |.
vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 71-321 4.1e-48 158.5 In-house 46-293 (310) alignment
Range on Protein: 71-321
Range on HMM: 46-293/310.0
MKAFKeaQEHGKNRYKDVGCLDHNRVKLHP--PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFack
..|.|  ..  |||| || |||  ||||.      .||||||.| |      |||.| ||...  ||| | .||. .||..||...|.|  ||  |.   
yeayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw...

dkPVLEFEEKGHKIIVKFESTGKMKFE--KNTDAKITETVFTVEGPGGLAQ-KVTQYHWIDWPDRGVPTADMAIVE--LLAKTRpsKGPTVVHCSAGIGR
  | |   |    | |   |    .||  . . . . . |   | |  | . .|.  .| .|||||||      |   |||. |  .|| |||||||..|
..pslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr..hgpcvvhcsagkdr

TGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.. || ... .|.|  |.... ....  ... .|   |||. |||....| . ..  .
lyvvvalklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifarge

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 71-327 2.4e-36 120.1 In-house 24-277 (283) alignment
Range on Protein: 71-327
Range on HMM: 24-277/283.0
MKAFKEA-QEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVS---TPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
    . | ... |||....   | .||.|..  ..||| | |.       . ...| .|.|||.   ||| |  .||. .| || ...|   .||. |. 
dadiasadenkrknrnqeivpadqwrvelkse.srdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

CKDkpVLEFEEkgHKIIVKFEsTGKMKFEKN-TDAKITetvftveGPGGLAQKVTQYHWIDWPDRGV--PTADMAIVELL--AKTRPSKGPTVVHCSAGI
 .     .. |    . .. | |..  | .     .         .    .  .. |  ||| . |   .   .  ....   .|.  ||| |||||.||
krG..sedyGe..ftvtlrke.ttsnsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgi

GRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNY--CLDKKMFDVD
|||.  . .   ....|    . .  .... .||||   .|| .|| .||...|.   | | ..  ||
Grtavfiaasasvkdalte.svvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd

0037934 (Phosphotyrosine protein) phosphatases II 73-317 1.1e-60 200.6 In-house 4-241 (243) alignment
Range on Protein: 73-317
Range on HMM: 4-241/243.0
AFKEAQEHGKNRYKDVGCLDHNRVKLhPPwpHDYIHANFVSTPsnPrRFICTQAPLDKSCAD----FWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAck
 ..  . . ||||.|. ..||.|||| ..  .|||.||..  .  | |.|.||.||.....|    || |. ......| ||.. .|.|..||. |.   
iallpenlsknrysdilpydhsrvkl.eg..sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

DKPvlEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG--PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTR------------PSKGPTV
..   ....    ..|.. |.          ...| .....|   ...| . |..||.. ||| |||.    ....| ..|            .|.||..
gev..tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSAGIGRTGSVVMIEYILDQLlggQqiEETDKILQKIREQRNN-SIQTDQQYLFVHQVILNY
||||||.|||| .... ..|..|   .     .......||||.. ..|| .|| |.....| .
VHCsaGvgRtGtliaaylmllll...g..vdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 74-235 1.1e-24 81.9 In-house 25-182 (297) alignment
Range on Protein: 74-235
Range on HMM: 25-182/297.0
FKEAQE---HGKNRYKDVGCLDHNRVKLHPPW-PHDYIHANFVSTPSNPR--RFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAC
|  |.      ||||.|.   | .||||      .||| |..|  | ..   ..|..| ||...  ||| .  .. |  | |.... | | .||  |.  
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

KDKPvlefEEKGHKIIVKFESTGKMKFEKntdAKITETVFTVEgpgGLAQKVTQYHWIDWPDRGVPTA
 ..       |  ...|.| |.   .|..    ..||  .         ..|.   .. ||| |||. 
vvqe....rlkagdvvveflsstsdefdr...viltelqliyr...sesrvvrhvqflswpdhGvpsd

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 75-318 9.5e-48 157.6 In-house 5-242 (250) alignment
Range on Protein: 75-318
Range on HMM: 5-242/250.0
KEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKkCCDYFackdkP
|. |.. |||| |.  ||. || |..       ||| | |. . .. . || ||.|| ..  ||| | |.||...| || |. |.. . . .|.     |
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw.....P

VLEFEEKGHkIIVKFESTgkmkfEKNTDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-----KGPTVVHCSAGIGRTGS
| . |. |. . |.  |.     |. .| .... . . .      . | |.|.. |||.|||    |..||| | . |     ..| .|.||||.||.|.
vekaekyGd.vtvsllsk.....eefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
 . |. .|..|   ....   |.....|..| ..... .|| ||...||.. 
fiaidavlerlkkekvvd.vfkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 75-319 6e-47 154.9 In-house 16-265 (270) alignment
Range on Protein: 75-319
Range on HMM: 16-265/270.0
KEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVS-TPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdk
. |...  |||.|.    . ||.|..        || ||.|    ......|....||. .  .|| | ..||| .| |. ...||| |||  |..    
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...

pvlefeEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEgPGGLAQKVTQYHWIDWPDRGVPTADM------AIVELLAKTR-----PSKG-PTVVHCS
      |...|. ...     .. ... .     |  ..|   |  .... ... .|||.|||...        ....|.. |      .|. |..||||
......epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
||.|||| ........  |   ..  .. .|....|..| . .|. .|| |.......|. 
aGvgRtGtlialDiavrlLee.tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 75-320 6.7e-42 138.2 In-house 39-278 (515) alignment
Range on Protein: 75-320
Range on HMM: 39-278/515.0
KEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKP
.|  .. |||||..  .| .||||   .    .||. | .. .  | . .|..|.|.. |  ||| . |||.|  | |. .  |    ||  |.  |   
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

VLEFEEkghkIIVKFESTgkmkfEKNTDAkITETVFTVEGPGglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG----PTVVHCSAGIGRTGSV
 ..| .    | |.  |.     |  |.. |  ..  . |    .. |||.|. .|||.|||    ... |. . . ..|    | ..|||||.|||| |
svkfGs....ikvelvsl.....eactgg.ikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv

VMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
. |. .. .   .. ..   .....||..|   .||..|| |.....|.. | 
isidsvvahakttrmvd.vfnfvtnirqkrpylvqtqeqyafiygavledllw

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 75-315 5.1e-33 109.2 In-house 4-238 (239) alignment
Range on Protein: 75-315
Range on HMM: 4-238/239.0
KEAQEHGKNRYKDVGCLDHNRVKLHP--PWPH-DYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdk
|.  .. |||| ..   ||.|| |      || ||| |...     .|. .|.||  .  |. ||| |  ||.   | ||  ..|   ||| .|.     
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

pvlefEEKGHKIIVKFEstgkmKFEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGS
       |  .. | .      | |  .|  |   |..  |     . | |||.  |||.|||    |.. |  |    . |   | |.|||||.||||.
.....tskycnlrvtlr.....ktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
...|. .| |    |.  .  . .. |||.|   .|| .||.|.|  .|
flvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl

0040439 (Phosphotyrosine protein) phosphatases II 76-320 1.2e-63 210.3 In-house 8-248 (249) alignment
Range on Protein: 76-320
Range on HMM: 8-248/249.0
EAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPV
    . ||||.|. ..||.||||..    ...|||.|......  .||||.||.||.....||| |. .... .| ||.. .|.| .||. |.    . .
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggs

LEFeekgHKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP------SKGPTVVHCSAGIGRTG
||.    ... |.. |. .        ...| ......    |   .|......|||| |||     ..... . |       ..||..||||||.||||
ley....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

SVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
 .... ..|.||   ...   . .....|.||....|...|| |.....| ..|.
tfiaaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk

0042113 (Phosphotyrosine protein) phosphatases II 76-317 3.7e-63 208.5 In-house 6-242 (245) alignment
Range on Protein: 76-317
Range on HMM: 6-242/245.0
EAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPV
    . ||||.|. ..||.|||| |. .   .|||.|..|...  ...||.||.||.....||| |. .... .|.||.. .|.| .||. |.    . .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

LEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP-----SKGPTVVHCSAGIGRTGS
|....    ..|.. |. .       ....| ....|.  . .  ..|..||...||| |||. .  ....|   |      |.||..||||||.|||| 
ltygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNY
.... ..|.||   . .   .......|.|| ...||..|| |.....|..
fiaaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallel

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 76-316 5.8e-33 109.0 In-house 4-238 (239) alignment
Range on Protein: 76-316
Range on HMM: 4-238/239.0
EAQEHGKNRYKDVGCLDHNRVKLHP--PWPH-DYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdkp
.  .. |||| ..   ||.|| |      || ||| |...     .|. .|.||  .  |. ||| |  ||.   | ||  ..|   ||| .|.      
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...

vlefEEKGHKIIVKFEstgkmKFEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGSV
      |  .. | .      | |  .|  |   |..  |     . | |||.  |||.|||    |.. |  |    . |   | |.|||||.||||..
....tskycnlrvtlr.....ktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

VMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
..|. .| |    |.  .  . .. |||.|   .|| .||.|.|  .|.
lvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 77-319 7.4e-38 125.7 In-house 23-256 (284) alignment
Range on Protein: 77-319
Range on HMM: 23-256/284.0
AQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCnimekgAKKCCDYFACKDKpvl
 |.  |||. ..   |.|.|||..       ||| | |..   .. ..| || ||| . |||| |  . .. .| .|        .||..|.  | .   
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv...

efeEKGHKIIVKFESTGKMKFekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK------TRPSKGPTVVHCSAGIGRTGSV
   .| ..  || .|  . .        . .   . .|     .|..|.|.  ||| |||   . .. |. |          . . |||||||.||||  
...ikeerfkvkvdsveesee.....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

VMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
.... .||..   .|..   ......|.|||. .|   || |..  .|.  |
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 78-321 3.2e-39 129.8 In-house 49-287 (297) alignment
Range on Protein: 78-321
Range on HMM: 49-287/297.0
Q-EHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVstPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNImEKGAKKCCDYFAckDKPVL
. .  |.|||..   | .||||.    .   ||. | ||  ..|  |.|.|| | . . |||| | |.|.|  | || .  ... |||  |..  || | 
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWs..dkgvt

EFeekGhKIIVKFESTGKMKfekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTAD--MAIVELLAKTR-----PSKGPTVVHCSAGIGRTGS
.|   | .. |. .|. . .        |  ..   .|     . | ||....|||. |.  |   ....|.   |      ..|| .|||.||.|||| 
tf...G.dvsvvllsvsere......GfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.. |. .. .    ....   ....|.|..| . .||..|| ||....|.. | .
lltidsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 78-316 1.7e-37 123.9 In-house 47-277 (439) alignment
Range on Protein: 78-316
Range on HMM: 47-277/439.0
QEHGKNRYKDVGCLDHNRVKL--HPPWPH-DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAkkccdYFACKDKPVLe
 .. |||||||| .|| || |   |  ||  || ||..    ... .| ||.| .... ||| . ...|.  | ||.|..|        |. .... .  
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy.

feekgHKIIVKFESTGKMkfekNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELL-----AKTRPSKGPTVVHCSAGIGRTGSVVM
       |.|. .   ..       .     ||     .   . | |.|.| |||. ||.    ....|     |. .   || |||||||.||||... 
.....gdiavrvdrniel....pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiia

IEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILN
..  |.||   ....  . |.. .|.||.. .|.  ||.|... .|.
ldialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 78-326 2.9e-24 80.2 In-house 46-287 (303) alignment
Range on Protein: 78-326
Range on HMM: 46-287/303.0
QEHGKNRYKDVGCLDHNRVKLHPpwpHDYIHANFVSTPSNpRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgAKKCCDYFACKDKPVLEFEE
..  |||. || |||| .|||       ||||...   |. .. | || || ...|||| | ...||  ...|    |   |   |.   ...  |.|||
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdsey.dklggdsvfprnqdflkfee

KGHKIivkfestGKMKFEKNTDAKITEtVFTVEgPGGLAQKVTQYHWIDWPDRGVPTAD-----M---AIVELLAKTRPSKgPTVVHCSAGIGRTGSVVM
.  ..       |..|  . .|      | .|   |     .  .|. .||   .|.            .  .| |  .|. |||    .| ||.|.  .
rsirv.......gefkrvelgdgwvlk.vlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

IEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDV
.|     |   |   .  | |...|. |  ..|   |. .|. .. .. ||. .  .
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickl

subfamily_ptpA1_pd Subfamily ptpA1 78-270 3.1e-21 70.6 In-house 46-249 (418) alignment
Range on Protein: 78-270
Range on HMM: 46-249/418.0
QEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTpSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKD-KPVL
..  |||| ..  ..| ||.|.        ||| ||..   . |..||||| || .. |||| |  ....  | ||    |.   ||  |.  .     .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

EFEEKGHKIIVKFeSTGKMKFEKNTDAKI-TETV-FTVEGpggLAQKVTQYHWIDWPDRGVPTADMAIVELLAK-------TRPS---KGPTVVHCSAGI
    .| ...  . |   ..  .. . .| |  . .|.||    .. .|||..  |||. .|     . .||           ||   . | .||||||.
siygngnevfgty.svelveviqdpereiitrnirltfeg...etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGSVVMI
||||...  
grtgtfcta

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 78-151 8.2e-06 19.6 In-house 36-117 (347) alignment
Range on Protein: 78-151
Range on HMM: 36-117/347.0
QEHGKNRYKDVGCLDHNRVKLHPP--------WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
..  ||| |||   |  || | |          .. || |  .      . .| || || ..  ||| |    ||  .  . 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

0045098 (Phosphotyrosine protein) phosphatases II 79-320 7e-65 214.5 In-house 33-274 (278) alignment
Range on Protein: 79-320
Range on HMM: 33-274/278.0
EHGKNRYKDVGCLDHNRVKlhppwphDYIHANFVSTPsnPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckDKPVLEFeek
   ||||||. ..||.|||       |||.|......  |..||.||.||.. .|||| |. .... .| ||.. .|.| .||. |.   .. .|..   
nldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggslty...

gHKIIVKFESTGKMkfEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTAD--M---AIVELLAKTRP--------------SKGPTVVHCSA
 ... |...|.  .  .. |  ... | .||| ...   .||..|.. ||| |||. .  .    ..| . . .               |.||..|||||
.gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GIGRTGSVVMIEYILDQLlggQQIEETDKILQKIREQRNN-SIQTDQQYLFVHQVILNYCLD
|.|||| .|.. ..|..|   ..    .......|.||.. ..|. .|| |.....| . | 
GvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 79-325 3.7e-48 158.8 In-house 50-293 (301) alignment
Range on Protein: 79-325
Range on HMM: 50-293/301.0
EHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEk
.. |.||. | |  .  |..        ||||...|. .|.|||.||.||.... ||| |. | .|. | ||.. .||  .|| .|.. | .  |. .  
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr.

gHKIivKFESTgKMKFEKNTdakiTETVFTV-EGPGGLA-QKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQ
 .||  | ... .. ..|..    ..  . | .  | .| . || | . .|.||||| . . . .|.   . |. | ||||||||||. . .  ||.  .
.fki..kiknk.elilnkki....skrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylare

LLGGQQIEETDkILQKIREQRNNSIQTDQQYLFV-----HQVILNYCLDKKMFD
..  ..|| |.  |...||.| |..|| .|  ..     ...| .| .| |...
veadptielte.alkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiye

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 79-315 2.6e-39 129.9 In-house 3-236 (237) alignment
Range on Protein: 79-315
Range on HMM: 3-236/237.0
EHGKNRYKDVGCLDHNRVKLHPPW-PHDYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVlefe
.. |||| .. . ||.|| |. .    ||| |...      |...|..| ||. || ||| |  |||   | ||  ..|.  .|| .|.   |.|     
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa....

EKGHkIIVKFestgkMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELL----AKTR--PSKGPTVVHCSAGIGRTGSVVMI
  |  . | .      | |. .|  .   . ....     . . ||..  |||||||    |.. .      ...  .  || ..|||||.|||| ...|
aygv.ltvsl.....kkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

EYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
. .| |    ... .  . .. | |.|   ||| .||.|.||.||
damlrqake.kkvvdiynyvysieedrpyiiqtkdqyvfihqtil

0049772 (Phosphotyrosine protein) phosphatases II 79-318 1.7e-36 121.9 In-house 46-280 (314) alignment
Range on Protein: 79-318
Range on HMM: 46-280/314.0
EHGKNRYKDVGCLDhNRVKLhPP---WPHDYIHANFVSTPsnpRRFICTQAPLDKSCADF----------WYMCL--QEKVDSIFM--------------
 . ||||.|. . | |||.| |      .|||.|..|...   ..||.||.||.  . ||          | | |  . .|  | |              
nrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCNIMEKGakkccDYFACKDKPVLEfeekghkiivkfestgkmkfE-------KntdakitetvftvegpgglAQKVTQYHWIDWPDRGVPTA
       |......|     ..   .| . |.                    |                            . . .|..|..|| ..|. 
aAlgKtpllildgng.....neptaadlellk....................eelydpelf...................erlgikylripvpDgsapll

DM--AIVELLAKTrPSKGPTVVHCSAGIGRTGSVVMIEYILDQLlggqQIeETDKILQKIREQRN-----NSIQTDQQYLFVHQVILNYC
..  ...|.. .  . .||..|||.||.||||. | . |.. .|    ..   ...|. .|..|      ..|.. .||.|.....|.|.
edfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 79-162 9.2e-08 25.9 In-house 34-119 (332) alignment
Range on Protein: 79-162
Range on HMM: 34-119/332.0
EHGKNRYKDVGCLDHNRVKLHPPWP-HDYIHANFVSTPSNPRRFICTQAPLDK-SCADFWYMCLQEKVDSIFMLCNIMEKGAKKCC
.   ||   . |.||.||.| |     |.  |..|   |.   .| .|||..  .   || |  . |   |... .| ||  .|. 
nmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

Y_phosphatase Protein-tyrosine phosphatase 81-316 2.8e-70 231.8 Pfam-A 3-235 (235) alignment
Range on Protein: 81-316
Range on HMM: 3-235/235.0
GKNRYKDVGCLDHNRVKL-HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKG
 ||||||. . |..|||| . . |.|||.||.|.. .....||.||.||.....||| |..|||| .|.||.. .||| .|| .|.  ...     ... 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slty

HKIIVKFEstgkmKFEKNTDAKITETVFTVEGPGG--LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYI
..| |. .     . ||. ....| ......  ..    ..|.|.|. .|||.|||.   ....|. | . ||    ||.|||||||.||||..|.....
gdikvelk.....ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

LDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
|.||  ...  .  .|....|.||....|. .|| |....||.
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 81-316 2.8e-70 231.8 In-house 3-235 (235) alignment
Range on Protein: 81-316
Range on HMM: 3-235/235.0
GKNRYKDVGCLDHNRVKL-HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKG
 ||||||. . |..|||| . . |.|||.||.|.. .....||.||.||.....||| |..|||| .|.||.. .||| .|| .|.  ...     ... 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slty

HKIIVKFEstgkmKFEKNTDAKITETVFTVEGPGG--LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYI
..| |. .     . ||. ....| ......  ..    ..|.|.|. .|||.|||.   ....|. | . ||    ||.|||||||.||||..|.....
gdikvelk.....ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

LDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
|.||  ...  .  .|....|.||....|. .|| |....||.
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

0041856 (Phosphotyrosine protein) phosphatases II 81-322 1.4e-45 150.5 In-house 3-175 (182) alignment
Range on Protein: 81-322
Range on HMM: 3-175/182.0
GKNRYKDVGCLDHNRvklhppwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCnimekgakkCCDYFAckdkpvlefeekgh
 ||||.|. . ||.|       . |||.||..  .  ..|||.||.||....|||. |  .... .| .|.         .. |..              
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............

kiivkfestgkmkfekntdakitetvftvegpGGLAQKVTQYHWIDWPDRGVPTaDMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQllgg
                                  | . ..||... ||| |||.    ..... . . ..||..||||||.||||..|.. ... .    
................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl....

qQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
 .    ..... .|..|.....| .|| |.....| ..| ||
.g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 81-321 3.3e-36 119.7 In-house 37-273 (285) alignment
Range on Protein: 81-321
Range on HMM: 37-273/285.0
GKNRYKDVGCLDHNRVKLHPpWPHDYIHANFVSTPSNP-RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKG
  ||| || |..  || |.    .|||||...  | .    .| || || .. .|||.|  |||.  ..||| ..| | .||. |.  |   |..| .  
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye

HKII-VKFESTGKMKFEKNTdakITETVFTVEGPggLAQKVTQYHWidWPDRGVPTADMAIVELL---AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILD
  .  .| |.     ..  |   ...|  .   |  |  .  |  |  |||.  |     ..||     |  | . | .||||||.||| ..| |.|   
itlteckeeaiagtilnalt...vintedassep..lymnhvqvpw..wpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

QLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
...   .||  | |....|  | ...|.  |.||.. |...| . .
rimenpniemld.ivremramrfqavqshmqflflyvvlmeyfige

0044763 (Phosphotyrosine protein) phosphatases II 91-320 5.1e-30 99.8 In-house 2-173 (178) alignment
Range on Protein: 91-320
Range on HMM: 2-173/178.0
LDHNRVKLHPPWP---HDYIHANFVStpsnPRRFICTQAPldkscADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvlefeekghkiivkfe
||..||.|...      |||.|...     |. ..... |     ||.. .  ......| .|.. .| |  ||. |.  .                   
ldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

stgkmkfekntdakitetvftvegpgglaqkvTQYHWIDWPDRGVPT---ADMAIVELLAKTR-PSKGPTVVHCSAGIGRTGSVVMIEYILDQllggqQI
                                 ||..| .|| |||.     ...||.. . . ...||..||||||.||.|..|.. ... .     ..
................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl

eETDKILQKIREQRNnSIQTDQQYLFVHQVILNYCLD
   ..... .||.|.  .... |. ..... | ..  
.sleeaielvrerRp.ivpnpgqlrqLyefelrllke

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 93-189 5.9e-08 27.1 In-house 7-89 (130) alignment
Range on Protein: 93-189
Range on HMM: 7-89/130.0
HNRVKlhppwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgakkcCDYFaCKDKPvLE-FEEkghKIIVKFEST
 .|..      ..||.|.||    . . .. ||.|| ... ||| | |.  |. . .|  . |.      .|.    .| || .||   .|||     
vsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deyw.pdseP.lewyee...diivtltdr

0046846 (Phosphotyrosine protein) phosphatases II 97-317 3.4e-40 133.0 In-house 5-172 (176) alignment
Range on Protein: 97-317
Range on HMM: 5-172/176.0
KLHPPWPHDYIHANFVSTPsnprRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdkpvleFEEKGHkiivkfestgkmkfek
.|..... |||.||.. ..    |.|.||.|| ...|||. | ...... ...|.. .|.|  ||..|.         .|. |.                
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.......leklgi................

ntdakitetvftvegpgglaqkvtQYHWIDWPDRGVPTAD--MAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQIEETDKILQKIR
                        ||....||| |||. .  . ..|.. . . ..||..||||||||||| .|..  .       ..    ...|...|
........................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvr

EQRN-NSIQTDQQYLFVHQVILNY
|||  ...||..|| |.....| .
eqRplgavqtpeQyrflyefelll

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 102-320 8.7e-30 98.8 In-house 44-261 (290) alignment
Range on Protein: 102-320
Range on HMM: 44-261/290.0
WPHDYIHANFVSTPSNpRRFICTQAPLDKS-------CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCdyFACKDkpvleFEEKGHKIIVKFESTGKMKF
   ||||||.|. |..  |.| ||.|. |          .||.|  ||||... |||. .|| |..    |||.      .  .    ..||.       
fnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl..faCak.....YvpesvgeelkfkgltvkCk

EKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIR
.| ..  . .   .|.  ..   .|| .   .| .. |.     ...|. | . || | .|||  || |   .  |.     . . ..  .. ..|...|
skekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

EQRNNSIQTDQQYLFVHQVILNYCLD
.||.. |...... ||  .|. .  .
kqralaitsalelafvdagivllaie

0043147 (Phosphotyrosine protein) phosphatases II 104-312 2.1e-39 130.3 In-house 5-155 (172) alignment
Range on Protein: 104-312
Range on HMM: 5-155/172.0
HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNImekgakkccdyfackdkpvlefeekghkiivkfestgkmkfekntdakit
.|||.|......  |.|||.||.||.  .|||| |. ..... |..|..                                                   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

etvftVEGPGGLAQKVTQYHWIDWPDRGVPtADMAIV---ELLAK--TRPSKGPTVVHCSAGIGRTGSVVMIEYILdqllG-GqqieETDKILQKIREQR
     .  | .| . . ||... ||| |||     .    |.. .   . ..||..||||||.|||| .|.. ..|             ..... .||.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl....sleeavalvrekR

NNSIQTDQQYLFVHQ
....|...|| |...
pgavqnpsqyrflyy

0036282 (Phosphotyrosine protein) phosphatases II 104-312 2.5e-39 130.1 In-house 2-164 (174) alignment
Range on Protein: 104-312
Range on HMM: 2-164/174.0
HDYIHANFVSTPSNPRRFICTQAPLDkscadFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdkpvlefeekghkiivkfestgkmkfekntdakit
.|||.|....    ..|.|..|.||.     ||.|. .... ...||.. .|.|  ||..|.                                      
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

etvftveGPGGLAQKVTQYHWIDWPDRGVPTADMaIVELLAKTRPS-----KGPTVVHCSAGIGRTGSVVMIEYILDQLLggQQIEETDKILQKIREQRN
        .  | . . ||... |||.|||. .. . |..   .       .||..||||||.|||| .|.. ..| .||  .  ..  ......| || 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp

NSIQTDQQYLFVHQ
...||..|| |...
gmvqtpsQyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 104-314 3.3e-29 96.8 In-house 3-149 (151) alignment
Range on Protein: 104-314
Range on HMM: 3-149/151.0
HDYIHANFVSTPsnprrFICTQAPLDkscaDFWYMCLQEKVDSIFMLCNIMEKGakKCCDYFACKDkpvlefeekghkiivkfestgkmkfekntdakit
 |||....|        ......||.    ||. .  ......|..|.. .| |  .| .|.   .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

etvftvegpgglaQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-KGPTVVHCSAGIGRTGSVVMIEYILDQllggqqiEETDKILQKIREQRNNSIQ
              .|......|||| |.|.   |..|.| . .   .||..||||||.|||| .|..  .| .          ...|. .|..| ...|
.............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq

TDQQYLFVHQVI
. ||.||.....
pnqqflfqlfal

subfamily_CG42327_pd Subfamily CG42327 104-249 1.2e-17 58.6 In-house 56-193 (319) alignment
Range on Protein: 104-249
Range on HMM: 56-193/319.0
HDYIHANFVSTP-SNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvlefeEKGHKIIVKFESTGKMKFEKntDAKI
  |..|..|  . . |  .|..|..|..| .||| .  . .   |  |... |.| |.| .|.  |.        ....   ..  | | .  |  |  .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket......ldntslyGdilvtlkgrevk..drya

TETVFTVEGPGGLAQKVTQYHWiDWPDRGVPTADMAIVELLAKTRPS
. |.   .  . .....| | . .|.. .||. . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

0051429 (Phosphotyrosine protein) phosphatases II 105-332 2.9e-45 150.3 In-house 5-239 (272) alignment
Range on Protein: 105-332
Range on HMM: 5-239/272.0
DYIHANFVSTPSN---PRRFICTQAPLDKSCADFWYMcLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEK-GHKIIVKFESTGKMKFEKNTDA
.||.|..|... .   |.|......||. ..||||..  ......|..|.. .|.|. ||  | .  .  .| ...     | . . .   ...|  .| 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

KITETVFTVEGPGGLAQKVTQYHWIDWPDRGVP-TADMAIVELLAKtrpsKGPTVVHCSAGIGRTGSVVMIEYILdQLLGGQQIEE--------TDKILQ
 ..| . | . . | | .|...|..||||.|||  |  ...|||..    .|| .||||||..||| ||.. ..| . .. ..| .         .....
ilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeave

KIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAH
..|.|| ...||..||||.....|..       .... ||.
elraqrpgavqteeqylflyeallellrsllsvraeyllaa

0049260 (Phosphotyrosine protein) phosphatases II 116-312 1.8e-34 114.0 In-house 6-144 (152) alignment
Range on Protein: 116-312
Range on HMM: 6-144/152.0
SNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkpvlefeekghkiivkfestgkmkfekntdakitetvftvegpggl
 .|..||.||.|.. ..|||| |  . ... | ||.. .|.|  ||  |.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

aqkvtQYHWIDWPDRGVPTADMAIVELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILdqllggqQIEETDKILQKIREQRNNSIQTDQQYLFVH
     ||... ||| |||. .. . .||       . ..||..||||||.|||| .|.. ..|       .  . ..... .||.|...... .|. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

Q
.
e

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 119-313 8.6e-09 29.8 In-house 4-198 (198) alignment
Range on Protein: 119-313
Range on HMM: 4-198/198.0
RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNiMEKgaKKCCDYFACKdkPVLefeEKGHKIIVKFESTGKMKfEKNTDAKITETVFTVEGPG-GLAQ
||.|.|| || .. |||| |  .     | |. .  .|  .| .||      |.    | |      .  | |     . |  ||  ..| .      ..
rryiatqhplretladfwqmvwetgsghivmvnd.dqk..nkeadypfyw..ptt...esgtgkygslsvttkti.ttkpdytitaliltnnttappstr

KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK-------GPTVVHCSAGIGRTGSVVMIEYILDQL-LGGQQIEETDKILQKIREQRNNSIQTDQQYLF
....| .  | ..  |   . .  ..|    ||        | .|||| | | ||  | ..  .         . .  .. ...|. |   | . |.| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

VHQV
..||
iyqv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 119-313 9.1e-09 29.8 In-house 5-199 (199) alignment
Range on Protein: 119-313
Range on HMM: 5-199/199.0
RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNiMEKgaKKCCDYFACKdkPVLefeEKGHKIIVKFESTGKMKfEKNTDAKITETVFTVEGPG-GLAQ
||.|.|| || .. |||| |  .     | |. .  .|  .| .||      |.    | |      .  | |     . |  ||  ..| .      ..
rryiatqhplretmadfwqmvwetgsghivmvnd.dqk..nkeadypfyw..ptt...esgtgkygslsvttkti.ttkpdytitaliltnnttappstr

KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK-------GPTVVHCSAGIGRTGSVVMIEYILDQL-LGGQQIEETDKILQKIREQRNNSIQTDQQYLF
....| .  | ..  |   . .  ..|    ||        | .|||| | | ||  | ..  .         . .  .. ...|. |   | . |.| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

VHQV
..||
iyqv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 127-320 1.1e-23 78.2 In-house 99-290 (302) alignment
Range on Protein: 127-320
Range on HMM: 99-290/302.0
PLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIvkfeSTgKMKFEKNTDAKiTETVFTVEGPGG-----LAQKVTQ
|  ...  .| .  | .|  .  ||...|.. ||| .|.. | . .|.| .   | .    |  | ..|. || | . ...|||         . . |  
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktv....sv.ktdleeftdkk.sfklytveiknekkkkkvkktvdi

YHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILdQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
 ..  ||| | |    . ...|      |   .||||||.||||..| | | . ||   ... .  .|.. .|. |  ..|..|| ...  ..    ..
lafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme

subfamily_hpo-7_pd Subfamily hpo-7 130-321 4.5e-17 56.8 In-house 45-230 (263) alignment
Range on Protein: 130-321
Range on HMM: 45-230/263.0
KSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckdkpvLEFEEKGHKIIVKFESTGKMKfekNTDAKITETVFTVEGpGGLAQKVTQYHWIDWPD
.  . |. .  | | . . |||.  |.| .||  ||       || .||     |.  .|  ..   ..  |  | . |..      ..|..| .  |..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfP......lekdekqklanvnvcttkvqs...dvllktlellstlge.KkkthtvkhysykgWie

RGVPTADMAIVELLAKTRPSKgPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD-----KILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.  |.    |...|  .| || . |||||.||||. . ...| .  ...   .  .|      ..|...|..|. .|.|  |  |   ..|.. |. 
kndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 131-325 9.5e-20 65.7 In-house 40-228 (255) alignment
Range on Protein: 131-325
Range on HMM: 40-228/255.0
SCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkiiVKFESTGkmkfeKNTDAK-ITETVFTVEGPGGLAQKVTQYHWIDWPD
. . |. .  | | . . |||.  |.| .||  ||  .    | ...      |.  .|        .|    | .. .  |    ...|. |..  |..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad......vnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGWie

RGVPTADMAIVELLAKTRPSKgPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD-----KILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMF
.  |     | ..|   | || . |||||.||||. . |..|..  ...   .  ||      ..|...|..|. .|.|  |  |   ..|..   |. .
knaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgel

D
.
e

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 132-321 1.7e-06 20.9 In-house 131-312 (346) alignment
Range on Protein: 132-321
Range on HMM: 131-312/346.0
CADFWYMCLQEKVDSIFMLCNiMEKGAKKCCDyfackdkpVLEFEEKGhkiivkFESTGKMKFE-KNTDAKITETVFTVEG-PGGLAQKV-TQ-YHWIDW
  |||||  ||... ....    .|  .            ... |. |      .. ||||  . . .|       .|.|  | | .. |  | .|   |
vedfwymiyqeqihlvylmvp.ddklknttts........lfndengg......yqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapw

PDRGVPTADMAIVELLAKT-----RPSKGPTVVhCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
     |   . |. .. .        . |  ||    | ||. | .   | ..||  | . .   .|...|..||  ....  ||  .. ....|   |
khlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepn.iceimknikqqrpggvesfaqyasiyaivfdyiark

0048179 (Phosphotyrosine protein) phosphatases II 175-312 3.4e-21 70.9 In-house 25-139 (144) alignment
Range on Protein: 175-312
Range on HMM: 25-139/144.0
FEEKGHKIIVKFESTGKMKFEKNTdakitetvftvegpgglaqkVTQYHWIDWPDRGVPTA---DMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIE
. . |.. .. . ..  . |....                    ..||....|||.|||.      ...|.. . ....||..||||||.||||..|.. 
lkklgittvinlteeyepeflere....................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

YILdqllgGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQ
 ..      ..    ...|. .|..| .......|. |...
lmk.....klg.lsleealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 202-316 1.2e-22 75.5 In-house 30-141 (145) alignment
Range on Protein: 202-316
Range on HMM: 30-141/145.0
ITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTA---DMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQiEETDKILQKIREQRN
||  .     . .| ....||....|||.|||.     ....|.. . ....||..||||||.||||..|..  .|      ..    ...|...|.|| 
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrp

NSIQTDQQYLFVHQVILN
.......|. |.....| 
gavpnpgqlrflyefele

subfamily_PTPDC1_pd Subfamily PTPDC1 204-314 1.1e-11 39.5 In-house 68-172 (182) alignment
Range on Protein: 204-314
Range on HMM: 68-172/182.0
ETVFTVEgPGGLAQKVTQYHWIDWPDRGVPTADM--AIVELLAKTrPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLggqqieETDKILQKIREQRNNSI
|. |. . .  |...   .. . |.| ||.. .    || ..| .  ..| . ||| || |||| ..    .  . |      ...| ....|..| .||
esGfsYd.lealmeqgiyvynfgwkDygvasleriLdivkvvafa.lqegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksi

QTDQQYLFVHQVI
|| .|  .|..  
qtreqvelvkefa

subfamily_PTPRN_pd Subfamily PTPRN 217-314 3e-18 60.6 In-house 187-288 (297) alignment
Range on Protein: 217-314
Range on HMM: 187-288/297.0
QKVTQYHWIDWPDRGVPTADMAIVELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQ
. |||.|.. ||..|||..  ...|.  |     |    | |||||.| ||||  ..|. .|..|| | .  .    |...|.||.. ..| .|. |. .
rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

VI
..
av

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 217-323 6.1e-17 56.1 In-house 89-201 (440) alignment
Range on Protein: 217-323
Range on HMM: 89-201/440.0
QKVTQYHWIDWPDRGVPTADMAIVELLAK-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVH
. . |||.  |||.|||     .....        . ..|| .|||||| |||| .. .. || .    .||.    ... .|..| . .|| .|| |||
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyafvh

QVILNY--CLDKKM
...|.   | |  .
eavlegllcgdtli

PTPc_DSPc_SM00012 218-315 4.2e-29 96.2 In-house 1-104 (105) alignment
Range on Protein: 218-315
Range on HMM: 1-104/105.0
KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG------PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVH
.|..||. .||| |||.   .|.|||.... .|       |.|||||||.|||| .|.....|.||  ...  .  .|....|.||....||..||||..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QVIL
...|
rall

0038934 (Phosphotyrosine protein) phosphatases II 218-311 9.4e-09 30.7 In-house 78-170 (194) alignment
Range on Protein: 218-311
Range on HMM: 78-170/194.0
KVTQYHWIDWPDRG-VPTADMAI-----VELLAkTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllGGQqieETDKILQKIREQRNNSIQTDQQYLFVH
   .|. . .||.| ||. ..       |.     . ..|  .||| ||.|||| .|    |      |      .. .. .|| |...|.. ...  ..
agieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr...lgm...saeeAialfrekRpgaipnqdyleall





PTEN_1 220-269 1.3e-08 29.9 In-house 95-149 (196) alignment
Range on Protein: 220-269
Range on HMM: 95-149/196.0
TQYHWIDWPDRGVPTADMAI--VELLAKTRP---SKGPTVVHCSAGIGRTGSVVM
 .|. ....| |.|. .. .  .. ..  .    ...  .||| ||.||.| ||.
veylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_DSP19_pd Subfamily DSP19 225-299 8.7e-07 23.4 In-house 64-132 (152) alignment
Range on Protein: 225-299
Range on HMM: 64-132/152.0
IDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDqllggQQIEETDKILQKIREQRNN
.| |.  . .   .... . ..| ..|  .|||.||. |. ||| | |..      ..  .. . |...||.| .
lDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iaylmk.....keelsleealelvrearpc

subfamily_CDKN3_pd Subfamily CDKN3 225-312 1.2e-06 22.3 In-house 105-190 (202) alignment
Range on Protein: 225-312
Range on HMM: 105-190/202.0
IDWPDRGVPT--ADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVmiEYILDQLlgGQQIEETDkILQKIREQRN-NSIQTDQQYLFVHQ
   .| .||   . . |.| |  .  .   |.|||  |.||.  |.    .|  |   ..||  |  ..|.|. .  ..||| .|| ....
ypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslvi..aclllyl..ddtiepkd.aidklrdlkgsraiqtvkqynylse

subfamily_DSP23_pd Subfamily DSP23 225-312 6.8e-06 20.8 In-house 57-140 (148) alignment
Range on Protein: 225-312
Range on HMM: 57-140/148.0
IDWPDRGVPTADM--AIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQIEETDKIlQKIREQRNNSIQTDQQYLFVHQ
.  .|   |. .    .|... ..   .    |||  | ||||...   ..       ...  .. |  ..|..|  |..| .|   |..
lriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvke.....rklaaaeai.aevrrlrpgsvetveqeklvrd

subfamily_CDC14_pd Subfamily CDC14 231-312 2e-06 21.9 In-house 245-320 (328) alignment
Range on Protein: 231-312
Range on HMM: 245-320/328.0
GVPTaDMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIeYILDQLlggqQIEETDkILQKIREQRNNSIQTD-QQYLFVHQ
..|. |. . ..|. .  ..|  .||| ||.||||...   |.. .     ..  .. ..  .|  |  |. .  |..|  .|
stPs.daivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkhy....rftaae.aiawlricrPGsvigpqqkfleekq

DSPc Dual specificity phosphatase, catalytic domain 239-294 1.4e-06 23.2 Pfam-A 62-114 (133) alignment
Range on Protein: 239-294
Range on HMM: 62-114/133.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDQLlgGQQIEETDKILQKIR
.|| ..| . ...  .||| ||| |..... | |....   . ...|  ..... |
avefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktk..nlslneAyefvkerr

DSPc Dual specificity phosphatase, catalytic domain 239-294 1.4e-06 23.2 In-house 62-114 (133) alignment
Range on Protein: 239-294
Range on HMM: 62-114/133.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDQLlgGQQIEETDKILQKIR
.|| ..| . ...  .||| ||| |..... | |....   . ...|  ..... |
avefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktk..nlslneAyefvkerr

PTPc_motif_SM00404 239-276 2.8e-06 22.3 In-house 69-106 (140) alignment
Range on Protein: 239-276
Range on HMM: 69-106/140.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQ
... . . . ..|  .||| ||. |...... ...  .
vldfienaekkggkvlVHCqaGvSRSatliiaYlmryr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 240-316 1.5e-16 55.2 In-house 218-293 (297) alignment
Range on Protein: 240-316
Range on HMM: 218-293/297.0
VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLlGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
.| |    | . ...||||||.||.| ||. . ||..|   ..| ..  ||...||||   .|| .|. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilakl.rkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_PTPN9_pd Subfamily PTPN9 245-322 1.4e-19 65.3 In-house 218-294 (297) alignment
Range on Protein: 245-322
Range on HMM: 218-294/297.0
KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| .||. | ||||||||||||  . ... |..|   ....   . ....|.||  ||||..|| | .. .|.| | .|
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvd.vvetvkllrtqrafsiqtpeqyefcylavleyalelk

subfamily_CG42327_pd Subfamily CG42327 246-318 1.4e-13 45.2 In-house 243-315 (319) alignment
Range on Protein: 246-318
Range on HMM: 243-315/319.0
TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|| |.|| ||||| |.|||| |.  .  . .|   ..  .  .... .|..| ....| .|| |...|. .|.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 249-315 2.7e-07 24.5 In-house 270-335 (347) alignment
Range on Protein: 249-315
Range on HMM: 270-335/347.0
SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
 . | || |  |. |. .||.   |..|.| |.   . |....|.|.||   .     | .  .  |
klapvvvmcdlgldrsatvvltsiiieqvldgkt.pdcddlfkkmrdqragvftmsifytyairaal

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 251-318 1.6e-09 31.9 In-house 263-344 (350) alignment
Range on Protein: 251-318
Range on HMM: 263-344/350.0
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEE-----------TD---KILQKIREQRNNSIQTDQQYLFVHQVILNYC
 | .||||||.|||| .| ....| ...  .....            |    |....|.|| . .|. .|..|... .|.| 
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 251-318 1.1e-06 22.3 In-house 266-344 (349) alignment
Range on Protein: 251-318
Range on HMM: 266-344/349.0
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQ----QI----EETDKI---LQKIREQRNNSIQTDQQYLFVHQVILNYC
 . .|||||| |||| .| ....|. |   |    .|       | |   . ..| || . .|  .|. .... .|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_PTEN_pd Subfamily PTEN 253-311 3.6e-06 22.1 In-house 117-173 (184) alignment
Range on Protein: 253-311
Range on HMM: 117-173/184.0
TVVHCSAGIGRTGSVVmIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVH
 |||| || |||| .. . |.| .||  .. ||. .. ...| . .....   |  .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve