Gene ZK484.7 in Caenorhabditis elegans

Synonym: CELE_ZK484.7, ZK484.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP237_AA protein Get Run
CeleP237_AA_37-319 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 28-322 6.3e-77 254.2 In-house 19-303 (308) alignment 
Range on Protein: 28-322
Range on HMM: 19-303/308.0
GTTAEKKTHRKQIVKFVKNalEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhpPWPHDYIHANFVSTP--SNPRRFICTQ
 ..  .|.. ....|....   ... .|..|| .. .. . .......  . . ||||||. ..||.||||  . ..|||.|..|...   .||.||.||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq

APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDK-PVLEFEekghKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYH
.||.....||| |. ...|  | ||....|.| .||. |.  . .  .||..    |. |.. |. .       .. .| ......   .|   .||..|
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfh

WIDWPDRGVPTADMAIVELLAKTRPS--KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
...||| |||.   .....| . | |  .||.|||||||.|||| .......|.||  . .     ....|.||||....|| .||||.....| |...|
ytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

K
.
l
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 32-335 2.8e-194 638.7 In-house 1-304 (305) alignment 
Range on Protein: 32-335
Range on HMM: 1-304/305.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKS
|||...|||.||||..||||||||||||.|||||||||||||||||||.||||||||||||.|||||..||||.|||||.||||.||.|||||||||.|.
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt

CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG
||||||||||.||..||||||..|||||||..|||.|||.||||||||.||.|||||....||.|...||.||||...||||. |.|||.||||||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLA
||.||.||.|||.|.||||||.||||||||||||||||.||||||||.||.||.|||||||||||||||||||.||||||||||||...||..|..|| |
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea

HLAF
. ||
ykaf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 32-322 1.2e-75 248.9 In-house 4-293 (305) alignment 
Range on Protein: 32-322
Range on HMM: 4-293/305.0
EKKTHRkQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMK-AFKEAQ----EHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNP-RRFICTQ
  .||   . .||. ||. |   || ||  . ..   .  . ||.  |    .  ||||.|| | |.. |||. | | ||||||.|  |  | .||||.|
ppqthp.iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaq

APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFeeKGhKIIVKFEStGKMKFEKntDAKITETVFTVEGPGGLAQKVTQYHWI
 |||..  .||.| .|.||. | |||. .| |  ||..|.       ||.  |.  |.|.  | |   .|.  ||.|  |.. .   |.    | . .| 
gpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel..ks.givvenvs.gskpmer..daeiqitllnltysgdqkmsvrhlqwt

DWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.||||||| . .. .|||.  | || | ||||||||||||..| |||||...   ..     .... .|.||  |||.| ||||.|.|.||| |.| 
ewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
subfamily_PTPRB_pd Subfamily PTPRB 32-322 4.9e-57 188.2 In-house 4-289 (293) alignment 
Range on Protein: 32-322
Range on HMM: 4-289/293.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPL
.|... ... ..||.  ..  ...  |.  .| ..  ...|| ..|... ||||...   ||.||||   .     ||| ||...  . || || || ||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl

DKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVlefeEKGhKIIVKFESTGKMKfekntdaKITETVFTVEGpGGLAQKVTQYHWIDWP
 ..  ||| |....|.  | || ...||| .|| .|.  ...||      | .| |.. .. ...       . .   ...|  .   .||.|||.. ||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv....lyG.dikvtlvaeeele.......dwvirelkiek.ekeerkvrqyhftsWp

DRGVPTADMAIVELLAKTR------PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| ||| .  ...... . |       ||.|.|||||||.||||  . .. .|...   . .. .  |....||.||. .|| .||.|.||..|... .|.
dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdif.givaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 32-317 1.3e-51 170.7 In-house 6-289 (298) alignment 
Range on Protein: 32-317
Range on HMM: 6-289/298.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFND---FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQ
|... .... |...   .|. .|. .||  ... ..    |.... .. . . |||| |.  ||. || |.        ||| | |... ..   || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEFEEKGHkIIVkfestgkMKFEKNTDAKITETVFTVEGP-GGLAQKVTQYHW
||| .. .||| |  .|.. .| || |. |..  |.  |.     |  . |. |. | |          .|.. |... . ..|.       ..| | |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkyw.....Pdegketyge.itv.......sllskeefadlivrklkvskkkeekerevrqlhf

IDWPDRGVPTADMAIVELLAKTRPS---KG--PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNY
. |||.|||.   ....||.| | |    |  | .|.||||.||.|. . |. .|...   | ..   .... .|..| ...|| .|| |.....|..
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvD.vfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 33-166 1.6e-17 58.3 In-house 8-151 (350) alignment 
Range on Protein: 33-166
Range on HMM: 8-151/350.0
KKTHRKQIvkFVKNALEKGPAGLRAEFAamKRFNDFEKMKAfkeAQEHGKNRYKDVGCLDHNRVKLH-----------PPWPHDYIHANFVSTP-----S
|... | |  . ||.  | .  | ..       ||..  .     .   |||||..   .|.||||.              . ||| ||... .      
krsklkli..itknstvksrlsLesdse..spsnDvilseG...velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsvei

NPR-RFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
||  ..| ||||| .   ||. ..|. ||  | .| . .| . .||  |. 
npdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq
0051299 (Phosphotyrosine protein) phosphatases II 35-318 9.1e-76 250.4 In-house 5-286 (288) alignment 
Range on Protein: 35-318
Range on HMM: 5-286/288.0
THRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKS
 . ....|.|.. | .|..||..|| .. ...   ...|..  . . ||||.|. ..||.||||... .   .|||.|...... ..|.||.||.||...
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt

CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-----PGGLAQKVTQYHWID
..||| |. ...|  | ||....|.| .||. |.    . .|....    | |.. |. .       ....| ....|.      ..|  ..||..|...
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytn

WPDRGVPTADMAIVELLAKTRPS----KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
||| |||.   .....| . | .    .||.|||||||.|||| .......|.||. . .  .  ......||||....|| .||.||....| |.
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 35-320 2.2e-72 239.7 In-house 9-306 (307) alignment 
Range on Protein: 35-320
Range on HMM: 9-306/307.0
THRKQIVKFVKNALEKGPAGLRAEFAAMKRFND--FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFV--------STPSNPRR
  .......|.  | ....||..||  ......    ......  . . ||||||. ..||.||||... .    .|||.|..|        ... ..|.
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG--PGGLAQK
||.||.||.....||| |. ...|  | ||.. .|.| .||. |.  . . .|....    . |.. |. .       ....| ....|.   . |   .
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrt

VTQYHWIDWPDRGVPTADMAIVELLAKTRP------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQI--EETDKILQKIREQRNNSIQTDQQYLFV
||..|...||| |||.    ..... . |       ..||..||||||.||||..... ..|.||  .. .     .......|||| ...|. .|| |.
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

HQVILNYCLD
....| ..|.
yeallelllk
subfamily_PTPRD_pd Subfamily PTPRD 36-318 4.3e-61 202.2 In-house 6-281 (564) alignment 
Range on Protein: 36-318
Range on HMM: 6-281/564.0
HRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAqEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSC
. ... ..|..   .. . .  |.  ... . |.. .| |.|    ||||...   ||.||.|..       ||| |.|. .  ... .| ||.|| ...
pvaelkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti

ADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEfEEKGHKIIVKFESTGKMKFEKNTDAKITETVftvegpGGLAQKVTQYHWIDWPDRGV
.||| |. .... .| || .. ||| .|| .|.     |  . .|.  ...|..|.. ...    .. |....          ...|.|.|...|||.||
edFWRmvweqnsstiVmltkleEkgkvkchkYW.....Pekg.tetygeltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgv

PTADMAIVELLAKTR----PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|.   ....|. | |    | .||.|||||||.||||  . |...|...   ....   ......|.|||  .|| .|| |.|..||.. 
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvD.iyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_PTPN6_pd Subfamily PTPN6 36-320 1.8e-50 166.7 In-house 9-299 (306) alignment 
Range on Protein: 36-320
Range on HMM: 9-299/306.0
HRKQIVKFVKNALEKGPAGLRAEFAAMKRF---NDFEKMKAFKeAQEHGKNRYKDVGCLDHNRVKL-HPPWPH-DYIHANFVS--TPSNPRRFICTQAPL
 .... .. |.  ... ||.  || ....    . ...... | .. . ||||| .   ||.||.| .|  |  ||| ||...  .... ...| ||  |
ieqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl

DKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKGHKIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWP
..  .||| | .||.   | |. . .|.| .||. |.  . .     || |.  . . ...      ...| .. | . . .  .. ...| |||. .||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek....eeyGkisvtnvsek......sladYilRelsvskkkkkkeerevfqyhfksWP

DRGVPTADMAIVELLAK----TRP----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLG--GQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
| |||.   |....| .    ..     ..||.||||||||||||....|. .|...     .   .  |. ...||||.  .||.||| ||...| .| 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

LD
  
et
0043336 (Phosphotyrosine protein) phosphatases II 37-318 9.4e-71 233.8 In-house 4-277 (278) alignment 
Range on Protein: 37-318
Range on HMM: 4-277/278.0
RKQIVKFVKNALEKGPAGLRAEFAAMKRFNDfEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCA
.|...|.... | .....|..||  . .|.  . .. ..  . . ||||||. ..||.||||..     ..|||.|..|.... ||.||.||.||.....
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGV
||| |. ...| .| ||.. .|.| .||. |.    . .|....    . |.. .. .       .. .| ....|.    |  ..||.||...||| ||
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgv

PTADMAIVELLAKTRP----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|.    ....| . |     |.||..||||||.|||| .......|.||  .. .   .......|||| ...||..|| |.....| |.
peslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN14_pd Subfamily PTPN14 37-318 2.5e-39 130.1 In-house 9-296 (300) alignment 
Range on Protein: 37-318
Range on HMM: 9-296/300.0
RKQIVKFVKNALEKGPagLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW--PHDYIHANFVSTP--SNPRRFICTQAPLDKSC
. . .| ... ||.|   . .|.  ... .   .... |  ..  |||.|||   ..|||.| |     ..|| |  ....  .. | .| .|.||.. .
kdkrakilekkleegk..vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltv

ADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIvkfestgkMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGV
 ||| |  ...|. | || .. |.| .|.  ||  ...   . | . .|..         || ...|. || ..     | .  ..|    ..||||.||
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvt........tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgv

PTADMAIVELLAKT----------R---PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|      .. | .           .    || | .||||||.|||| ... . ..  |  ...|.  .|.|...||||   .||  || ||..|...| 
PeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 38-324 4.3e-64 210.9 In-house 12-289 (290) alignment 
Range on Protein: 38-324
Range on HMM: 12-289/290.0
KQIVKFVKNALEKGPAGLRAEFA-AMKRF--NDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPrrFICTQAPLDKSCAD
. . ||  .. .|.. .|  |.   .| .   .. . | | .  |  ||||||| | |  || |.   . ||.|||.|     .  || || .| ..  |
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkam..filtqGalkdtvid

FWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghKIIVKFEstgkmkfEKNTDAKITETVFTVE-GPGGLAQKVTQYHWIDWPDRGVP
.| | |||||  | |||...|.|  || .|.  |.  || | |     ..  |       |.. ||.|   ...|     |   |.  .. . |||. |.
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe...itvlcse.......eddkdaniikktlsvrdkdsGkehklkhlkikswpdksva

TADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKIlQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMF
 ...|.. .|   |   || ||||||||||||. | ||  |. || |....  | . . .|. | ||.| | ||| . ...|..  | | .
lstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlv.ralrnsrlnsvqvdiqylalveilldlGkdfkyi
subfamily_PTPRG_pd Subfamily PTPRG 38-327 1.8e-49 163.4 In-house 4-296 (563) alignment 
Range on Protein: 38-327
Range on HMM: 4-296/563.0
KQIVKFVKNALEKGPAGLRAEFAAMKR--FNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSNPRRFICTQAPLDKS
|. .| | .   .|  |. .|| |...   ..  .... .. ... |||| ..   |. ||||.|       .||| ||..      . || || || . 
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkDKPvlefeEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG
. ||| |  ...|  | |. |. |.|..||  |.   |..     |.  .. |. ... ..        .| ..    .      ..|.|||. .||| |
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.des.....etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg

VPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVD
||.  .  .    |    ..   ||.|||||||.||||  .... .| |.   ... .  ..|..|| |||. .||  ||.|.|...|.  . |.   ..
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 38-318 3.3e-43 142.7 In-house 5-278 (287) alignment 
Range on Protein: 38-318
Range on HMM: 5-278/287.0
KQIVKFVKNALEKGPAGLRAEFAAMKRFNDFE-KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
... .||..  .||  | .  |. ... .. | ..      | . |||....   | .|| |.    .||| | |. . .. ..|| ...|. .   .||
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfW

YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvLEFEEkgHKIIVKFEStgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG-VPTA
 .  ...|  | |||. .|.  ..| .|.. ..   . . |  ..| .  |        .|..  . .   . ..  |  |.|.||.  .|...| |.. 
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe..yniellnee.......vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep

--DMAIVELLAKT--RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
   . ..|   ||  ...... |||||...||..  . ..  ...      |.   ..|.. | |. .|.|| .|| |. ...|.| 
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleyl
0040438 (Phosphotyrosine protein) phosphatases II 39-331 5.1e-76 251.3 In-house 4-289 (317) alignment 
Range on Protein: 39-331
Range on HMM: 4-289/317.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFeKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADF
.......  | ..  .|. ||  . ...    .. ..  . ..||||.|. ..||.||||.|. .   .|||.|..|..|. .|.||.||.||.....||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPVLEFeekgHKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPT
| |. ...| .| ||.. .|.| .||. |.    . .|..    ....|.. |. .       .| || ....||.  ..   .||..|...||| ||| 
wrmvweqgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp

ADMAIVELLAKTRPS----KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKL
    ....| . | .    .||..||||||.||||........|.||  ....   .......||||....|| .|| |.....|.|.. | ..  . .|
spdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel

A
.
k
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 39-318 4e-51 169.0 In-house 8-283 (305) alignment 
Range on Protein: 39-318
Range on HMM: 8-283/305.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFekMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADF
.. ...|.|  .   || |.. .. . ..   ..  |. ... |||.|..  ||..|..| .   .   ||| |..| . ..  ..| .|.||..  |||
dlaayikearvysdkgleaqykslyeeees..idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf

WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFeeKGHKIIVKFESTGKMKFEKNTDAKITETvftvegpGGLAQKVTQYHWIDWPDRGVPTA
|.. ..||| .| ||....| | .||  |.. . . . ||     ....| |.| .  .|..  . | ..           . |.||.  |||| |||. 
WrliveekvstivmltklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiede.......dkesrtvlqyqltdWPdhGvpqf

DMAIVELLAK----TRPSKG-PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
  ....|. .     . .|| | .||||||.||||  ....  |..|   ....   ..|...|..| . .|| .|| |.|... .. 
atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvd.vfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 39-323 1.3e-50 167.1 In-house 5-276 (288) alignment 
Range on Protein: 39-323
Range on HMM: 5-276/288.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFkeAQEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
 |  ...  |. . .||  |.      .  . ...|   ..  ..||... . |  ||||.   |. ||.|| ||.  ..||.||.||||.     .| |
vinawirlvlqiaveglkkeyrdspneasidiidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

CLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKghkiivkfESTGKMKFeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMA
 |.. |. | |||...||| .|  .||  |      .            .  | |  .. |  .. ... .. .|  .. | . |. .|.| |||   ..
llesdveyivmlcellekGkeksaeyfPsklGekarigrl........ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenyls

IVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKM
 . ||   .  . | |||.|||.|||| ...|  .|..|   .      ..|.| ||.| ..||| .|||.||...|.. | || 
plrllevlkslqkPivvhssaGvGrtgtlililialeslrl.ddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 39-318 3.1e-46 152.5 In-house 6-283 (290) alignment 
Range on Protein: 39-318
Range on HMM: 6-283/290.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH-----DYIHANFVSTPSNPRRFICTQAPLDKSCA
.  .|| |   ||  | |..| ... ..  ....     ... .||....   | ||. |.|   |     .||.| ..   .. ...| ||.|. .  .
kfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVleFEEKGHKIivkfestgkmKFEKNTDaKITETVFTVEGPG--GLAQKVTQYHWIDWPDRG
||| .  ||||  | ||.||.|.| .||  |.. .|     ..|   |.            |.... ...|. . |.     | .|.||||.   |.. |
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikl..........lneetln.eyierklevknknsagakqsvtqyqitnwdstg

----VPTADMAIVELLA-KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
      |  ..| |    . .. ... |||||...||..  . ..  ...    ..|.   ..|.. | |. .|.|| ||| ...|..|.| 
kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvid.vfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN9_pd Subfamily PTPN9 39-248 9e-36 118.4 In-house 2-204 (297) alignment 
Range on Protein: 39-248
Range on HMM: 2-204/297.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADF
.| ..|.   |||  ||. |.|.... .   ...|.|   .  ||||.|| |.|. ||.|         |||.||||    ... || || ||.| . ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKfestgKMKFEKNTDakITETVFTVE-GPGGLAQKVTQYHWIDWPDRGVPT
| |  ...|  | |   ..|.|  ||  |.  ... . || .    . |.     ... |.. |   ...|....    .  .||| .  . ||| ||| 
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgd....lsvs.....nveveeeed..ykvrvleiknvkteesrkvthfqflsWPdyGvPs

ADMAIVELLAKTRP
. ......| | | 
saaslldvlekvre
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 39-321 6.6e-28 92.0 In-house 15-288 (302) alignment 
Range on Protein: 39-321
Range on HMM: 15-288/302.0
QIVKFVKNaleKGPAGLRAEFAAMKRF-NDFEKMKAFKEAQEhgKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSC---AD
. .|.||.      | ...|| ... .  | || ||||.  .  ||. .|| .||.|.|||.   | .|..|  |. |.  |  | .| |  .|    ..
eakklvks...ldtaevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvkle.aepdsyvnaskvevPeltrsiilaQlpkvdsedsvee

FWYMCLQEKVDSIFMLcnIMEKGAKKCCDYFACKDKPvlEFEEKGhKIIVKfestgKMKFEKNTDAKiteTVFTVE-GPGGLAQKV--TQYHWIDWPDRG
|| |  |||. |...|  ..|.  ||  . . .|     ...| | |. |      . | ||  ..|   | ...|  | | .. |  . |.   |..  
FWrmvfqekivsvvil..vgeeelkktlselfpkksg..dykeyg.kmfvN.....nrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkk

VPTADMAIVELL----AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
||.   ....      ||. ... .||.    |.|| |...     ...|  |..  .   |...||.|| ..... .|| ... ..| | . |
vpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkep.nikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 40-317 4e-53 175.4 In-house 8-278 (288) alignment 
Range on Protein: 40-317
Range on HMM: 8-278/288.0
IVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
 |. |...  .. .|.  |. ..  ..  .. .| ..|. . ||||...  .|..||||.        ||| |...    . ...|.||.|| ..  |||
pvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLeFeekGHkIIVKfestgkMKFEKNTDAKITETVFTVegPGGLAQKVTQYHWIDWPDRGVPTAD
 .  ..|.  | || ...|.| .|| .|.  .|||.. .   |. . |.      .. .|...  .....  .    .   ..|||..  ||| ||| . 
elvyenktstivmltelveggktkCeeYWPdadkpkn.y...Gs.vtvt......lveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPesk

MAIVELLAK---TRPSK-GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNY
. ..||| .   . ... || .||||||.||||  . .. ..|..   ..|. .. ...|.|.||.. .|| .|| |...|.|. 
apllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevllsl
subfamily_PTPRN_pd Subfamily PTPRN 40-167 1.4e-15 51.8 In-house 17-148 (297) alignment 
Range on Protein: 40-167
Range on HMM: 17-148/297.0
IVKFVKNALEKgPAGLRAEFAAMKRFNDFEKMK-AFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTpSNPRR--FICTQAPLDKSCA
....... |.. .  |..|. |.....  .. | . |. .   |||.|.|   ||.||||.       .||| | ..   ..||.  .| ||.|| .. |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastva

DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAC
||| |  .. |  | .|... |.| |.|  |.  
dfwqmvweqGvvvivnltrleeegvkqckrywpd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 41-319 8.8e-51 167.8 In-house 8-281 (318) alignment 
Range on Protein: 41-319
Range on HMM: 8-281/318.0
VKFVKNALEKGPAGLRAEFAAMKRF-NDFEKMKAfKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
 . |..  |.|   | .|. ...|  . . ..|.  |   . |||| ..   || ||||..       ||| ||..    . . .| .|||| . . |||
eshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfW

YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvLEFEekghKIIVKFESTGKMKFEKNTDAKITETvftvegPGGLAQKVTQYHWIDWPDRGVPTAD
 |  . .   | || ...|.| .|.  |.  |.    ...    |. |. ... ...       |.|.|           ..| |||. .|||.|||.  
rmvWeqnsavivmltqeeergkakvhryWPskgs..rsyg....klvvelkeevelsdyvlrefkvtrt......eeeesrqvrqyhytsWpdegvpesg

MAIVELLAKTR-----PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
. ...|. ...     ...||.|||||||.||||  .... .|...   . ..   .. ...|||||  .||..|| |...|.|..  
aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 41-341 1.1e-44 147.5 In-house 7-298 (312) alignment 
Range on Protein: 41-341
Range on HMM: 7-298/312.0
VKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEhgKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCL
 |.    .   |  |  |. |.       .  ||   ..   ||| .. | |  |  |       |||||||   ..| ||.|||.||...|. || ..|
kkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlal

QEKVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFEEkgHKiiVKFESTGKMKFEKNTDAKITETVFTV-EGPGGLAQKVTQYHWIDWPDRGVPTADMAI
     || .|| ..| |..||. | .      ...|.  |.  |  |.  ...   ..  |||  |. |     |   |. .| |  ||| |.| .  . 
slgstsiillcgfvedgsekcakyisdi.vgfvdled..hr..vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdta

VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKlAHLAFTEKY
  ||.  .  | | . |||||.||||....|| ..  |   .. .   ...  .| .|  |...  ||... ...|..   | ..  . .  .  | | |
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqn.vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneq.ewtkfkety

MK
 |
ak
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 42-341 1.1e-74 246.2 In-house 5-300 (307) alignment 
Range on Protein: 42-341
Range on HMM: 5-300/307.0
KFVKNALEKGPAGLRAEFAAMKRFNDF-EKMKAFKEAQEhgKNRYKDVGCLDHNRVKLH-PPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMC
 .|...|.||   |. ||  . . .     ..||.  ..  ||||.|| | |..|. .. .    ||||||.. .  .|..|||.| ||...  .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama

LQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEkntDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAI
.||||.|. |||...| .  || .|.  ..   | | |... | |.   ..|.  .   .  |  | . |.  .. .. .... | .|||||||  ... 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapd...edlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinlta

VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAHLAFTEKY
..||  .|  . | |||||||.||.|..| | .. |... |.   . .|.....|.||. .|||. |||..|.|.|.| |..     .  |    . |||
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeeky

MK
 |
ak
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 42-318 2.2e-52 172.9 In-house 4-276 (281) alignment 
Range on Protein: 42-318
Range on HMM: 4-276/281.0
KFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
| .|.  ..  ||.  |.....  .  .  .| |. .   ||||...   |. |||..|       ||| ||||.. ......| ||.|. .|...|| |
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm

CLQEKVDSIFMLCNIMEKGAKKCCDYFAcKDKPvlefEEKGHKIIVKFEStgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMA
 ...||. | |. . .|.|  ||  |.   |.     | |  ...||...       ... |.  | .|..|  .| ...|.| ... ||| |||.  ..
vweqkvsaivmvtreieagklkChrYWP.ddns....elkygdvtvksta.......eeekatyierkfkleresgetreveqlaytaWPdhGvPattke

IVELLAKT----R-PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..|  ..     .  .| | |.|||||.||||. . .. .....   ..  . . .....|..||  .||  || ||....|.. 
llefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 42-333 1.8e-51 170.1 In-house 12-295 (319) alignment 
Range on Protein: 42-333
Range on HMM: 12-295/319.0
KFVKNALEKGPAGLRAEFAAMKRFNDFeKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
. .|.  ..|  .|. ||  .|  ... ...  .. . . ||||...   |. ||.| .       ||| |.|. .  . ..|| |||||..   ||| |
erlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm

CLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEFEEKGhKIIVKFESTGKMKFEKNTDAKITETVFTVEGpgglaQKVTQYHWIDWPDRGVPTADMA
  .|..  . ||... ||.  |.  |.     |  .||| | ..||. |.  ...     . |. .    ||       .|..... .||| .||.  ..
vWeeessivvmltklveklkvklkkyw.....peenfeeyG.rlivtleeeeeledyiirklklnkkssevet.....RevkhfqyteWpdhdvPekats

IVELLAK-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCldkKMFDVDVKLAHL
...|| .      ....|| |||||||.||||. .... .|...   . ..   .. ...| |||  .|. .|| |.....|..    ...| .... .|
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlD.vfstvsrlRtqRnimvqrpeqYkfiyealleav...eagdteievqdl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 43-316 1.4e-40 134.2 In-house 14-277 (315) alignment 
Range on Protein: 43-316
Range on HMM: 14-277/315.0
FVKNALEKGPAGLRAEFAAMKRfNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMC
.| .       |.. .. ..    ..  ..  |. ... |||| ..   |. ||.|         ||. |||.   . .||.|..|.|.  |  ||| . 
yvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv

LQEKVDSIFMLCNIMEKGAKKCCDYFACKdkpvlefeekgHKIIVKFESTgKMKFEKNTDAKItETVFTVEgpGGLAQKVTQYHWIDWPDRGVPTADMAI
 .|..  | || |..|.  .|.  |.  |           . |  |.  | ... |.||.  .  |. .|   |   ..| |.|.  ||| |||   ...
feedigkivmltnlvegekrkaekywpdk...........kviyGkitvt.rkseevnteytv.rtlsvvf..gdnirevvqlhytswpdmgvpkytipl

VELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILN
..|  .       | |. |||||||.||||. . .. .|||.   . |.   ......|..| . .|. .|| |.....|.
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN3_pd Subfamily PTPN3 44-317 2.9e-51 169.0 In-house 8-274 (280) alignment 
Range on Protein: 44-317
Range on HMM: 8-274/280.0
VKNALEKGPagLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPhDYIHANFVSTPSNP----RRFICTQAPLDKSCADFWYMC
.|..||.|   . |.|  . | .   ...| . ...  ||||.|.   |. ||||.     ||| ||.|.  ..      |.| || ||.|...|||.| 
lkeglesGa..vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmv

LQEKVDSIFMLCNIMEKGAKKCCDYFACKDkPVLEFEekghKIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAI
 ..|.  | || ...|.| .||. |.  ..   ||.     .. || |..      ..| . ..  .   .      .|..|  ...||| |||.    .
weqksslivmlttlverGrvkChqyWPete.deleyg....efsvkceke......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadf

VELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNY
.|.. . |  .     |.|||||||||||| ....|  |  .   ...   | |....|.|| . .|| .|| || . ||. 
lefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypld.ivrtmrdqramlvqtasqykfvCeailkv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 44-165 3.2e-11 37.1 In-house 18-153 (349) alignment 
Range on Protein: 44-165
Range on HMM: 18-153/349.0
VKNALEKGPAGLRAEFAamKRFNDFEKMKAfkeAQEHGKNRYKDVGCLDHNRVKLH-----------------PPWPHDYIHANFVSTP--SNPRRFICT
 |..  | .  | ..       .|..  .     .   ||||||.   .| ||||.                    ..||| ||... .  |  ...|.|
tkysksksmlslesddd..seiddvilseG...velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiat

QAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYF
||||  .  ||. . | ..|  .. | .  |.. .||  |.
qaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
subfamily_Ptp69D_pd Subfamily Ptp69D 45-320 5.4e-49 162.0 In-house 14-288 (307) alignment 
Range on Protein: 45-320
Range on HMM: 14-288/307.0
KNALEKGPAGLRAEFAAMKRFnDFEKMKAFKEAQE-HGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCL
|.  ..   ||  |.  ...   ..|   . | .|   ||||.|.   |..||||..   .   ||| |.|. .  . ..||. |.|..    ||| |  
ksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia

QEKVDSIFMLCNIMEKGAKKCCDYFACKdkPVLEFEekghKIIVKFESTGKMKFEKNTDAKITETVFTVeGPGGLAQKVTQYHWIDWPDRGVPTADMAIV
. .|  | || |. ||  |||  |..       ...    .|.||. |. |..   . . .....  .. |     .||.|||.  |.|  || .  ...
eqevtlivmlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvPevargll

ELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.|. .     . ...| ||||||| ||.| .| .. .|.||   ....   .. ...|.|||  .|  .|| |... .|.|   
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif.etvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPN23_pd Subfamily PTPN23 45-318 5.5e-43 141.8 In-house 7-280 (288) alignment 
Range on Protein: 45-318
Range on HMM: 7-280/288.0
KNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEA--QEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVS--TPSNPrRFICTQAPLDKSCADFWYMCL
...  .| ..| ..|. ... .| |  |    .      |||..|.   |||||||.     ||| | ||   .|  |  ||.|||||... .||| |  
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvy

QEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkiivkfeSTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIV
..|.  | || .  |.| .|.  |.  .     .|..           .  .| ...|.  .  ..     .    ..|.  ..  ||. ||| .   ..
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetll

ELLA--------KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..|         . |.|| | |||||||.|||| . ..  .. .|  |. . .. ......|||| ...|. .|. |. ...|.. 
qfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 48-322 2.7e-35 117.1 In-house 18-292 (325) alignment 
Range on Protein: 48-322
Range on HMM: 18-292/325.0
LEKGPAGLRAEFAAMKRFNDFEKMKAFKeAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKv
  .   |.  ||  .   .   |  | |  ..  |||.|.|  ||..|| |         ||| |... .  .   |. .|||| ..  |.| . |. . 
kaqdqdgfahefgllpsddgiakkvamk.penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.

DSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMkfeknTDakITETVFTVEGP-GGLAQKVTQYHWIDWPDRGVPTADM---AIV
 |. .. |....| ..|. |.  .     .|      . ||. .  ..     .|      |. | .. .| .. | |...  |.| ||.       .|.
csvvvvlneldlgkdrcavywpkemgksktfG....glevklrtieei.....sd..yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

ELLA-------KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.|.            . .| .||||||.||||  . .  .|....   ...   . ..|.|..| . ..|  || .... . .. .  .
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdif.gfvkklrkdrpsmvetvdqyiliyealveaymsgn
0039614 (Phosphotyrosine protein) phosphatases II 50-321 2.8e-70 232.5 In-house 29-292 (297) alignment 
Range on Protein: 50-321
Range on HMM: 29-292/297.0
KGPAGLRAEFAAMKRFNDfEkMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSN-PRRFICTQAPLDKSCADFWYMCLQEKV
... .|..||  ...... . .. ..  .   ||||||. ..||.||||.|.      .|||.|..|....  .|.||.||.||.....||| |. ...|
nsktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv

DSIFMLCNIMEKGAkKCCDYFACKDKpvlefeeKGHKIIVKFESTGKmkfekntDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAIVELLA
 .| ||.. .|.|  ||..|.  .         . ... |.. .. .       .. .| ....|.  .|   .||......||| |||     . |.| 
tvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslelllefle

KTRP------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
. |       ..||..||||||.||||..... ..|.||  ....   .......||||....||..|| |.....| ... |
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
0047943 (Phosphotyrosine protein) phosphatases II 51-318 1.7e-71 236.2 In-house 10-272 (273) alignment 
Range on Protein: 51-318
Range on HMM: 10-272/273.0
GPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFML
|...|..|| ..... .  ......  . . ||||||. ..||.|||| .. ..|||.|..|...  .|.||.||.||.....||| |. ...|  | ||
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

CNIMEKGAKKCCDYFACKDKP-VLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP
....|.| .||. |.  .    .|....    ..|.. |. .       .. .| ......    |   .||..|. .||| |||.    ..|.. . | 
telvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
      |.||.|||||||.||||........||||  ....   .......|.|| ...|| .||.|.....|.|.
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 51-319 1.1e-38 128.3 In-house 32-292 (319) alignment 
Range on Protein: 51-319
Range on HMM: 32-292/319.0
GPAGLRAEFAAM-KRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDS
    |..|| .. |.  .  ...     |.  |||. ..   |.|.|||..       ||| | ||.   .. ..| .| ||| . |||| |  . .. .
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

IFMLCnimekgAKKCCDYFACKdkpvleFEEKGHKIIVKFESTGKMKFekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK-
| .|        .||..|.  |       ..|  .  || .|  . .        . .   . .|     .|.||.|.  ||| |||   . .. |. | 
ivllt......kdkcsqywplk......ivikeerfkvkvdsveetae.....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv

-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
         . . |||||||.||||  .... .||..   .|..   .... .|.|||. .|   || |..  .|.  |
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalleehl
0036941 (Phosphotyrosine protein) phosphatases II 52-333 6.5e-77 254.1 In-house 12-292 (297) alignment 
Range on Protein: 52-333
Range on HMM: 12-292/297.0
PAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
.|.|. ||  . ..    ......  .   ||||||. ..||.|||| .. ..|||.|..|.... .|.||.||.||.....||| |.....| .| ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NIMEKGAKKCCDYFACKDKPVLEFeekgHKIIVKFESTGKMkfeknTDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP--
. .|.| .||. |.  .   .|..    ....|.. |. ..     ... .| ....|.   .|   .||..|...||| |||.    ..... . |   
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLG--GQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAHL
    |.||..||||||.||.|........|.|| .   ..     ....|.||||....|| .||.|.....|.... |...  ..||..|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 53-321 3.8e-34 112.7 In-house 20-239 (392) alignment 
Range on Protein: 53-321
Range on HMM: 20-239/392.0
AGLRAEFAAMKRFNDFEKMKAFKEaQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
| .  ||  .   . ...  | ||  .  |||||..  .| .||||        .||. | .. .  | . .|..|.|   |  ||| | .||.| .| |
alffeefhdlpgpdiypqtvaqke.inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam

LCNIMEKGakkccdyfackdkpvlefeekghkiivkfestgkmkfekntdakitetvftvegPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS
. .. |                                                         |  |. |.|.|. .|||..||    ...... . .  
vtklkegd......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad

KG----PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
 |    | ..|||||.|||| |. |. .. .    . . .  ... .||..|   .||..|| |..  .|.  | .
fGqythpliihcsagvgrtgvvisidsvvahakktrmv.dvfnfvtnirrkrpymvqtkeqyafiygavledllwr
0046845 (Phosphotyrosine protein) phosphatases II 54-322 1.5e-73 242.9 In-house 1-278 (284) alignment 
Range on Protein: 54-322
Range on HMM: 1-278/284.0
GLRAEFAAMKRFNDFE--KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTP-----SNPRRFICTQAPLDKSCADFWYMCLQE
||..|| .. ... .   ......  . . ||||||. ..||.||||... .    .|||.|..|...      ....||.||.||.....||| |....
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFeekgHKIIVKFESTGKmkfekNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVEL
.|  | ||....|.| .||. |.  . . ||..    ....|.. |. .     . | ....   | .|..|   .||..|...|||.|||.    ..|.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef

LAKTRPS------KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQ--IEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| . | .      .||.|||||||.|||| .......|.||  ...       ......||||....|| .||.||....|.|.. |.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
subfamily_PTPN12_pd Subfamily PTPN12 54-319 9.3e-55 180.5 In-house 16-278 (290) alignment 
Range on Protein: 54-319
Range on HMM: 16-278/290.0
GLRAEFAAMKRFNDFEKMKAfKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFML
 |... ...|. . ... .. .. ..  ||||||.   |..||.|.    .   ||| |||.  .... ..| .|.|| |   ||| |  . .|  . |.
klkklsekykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvma

CNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKFEStgkmkfEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
|...| | |||  |.. . .  |||.|    . |. |.      ||..|  ..   ..||   .  .||.|.|. .|||.|||..   ..||... |   
CrevelgkkkCerYWpeegeeelefge....fevtlee......ekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelq

---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD--KILQKIREQRNNSIQTDQQYLFVHQVILNYCL
   . | |||||||.|||| .. |.|. ..|  ..  || |  ......|.||.  .|| .|| .|.. ..... 
esedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
DSPc_SM00195 55-318 4.4e-74 244.5 In-house 2-262 (263) alignment 
Range on Protein: 55-318
Range on HMM: 2-262/263.0
LRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
|..||  ... .  ....  .. ... |||||.. . ||.||||...    ..|||.||...........|.||.||.. ..||| |...|||  | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntdAKITETVFTVEGPGG-LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
. .|.| .|| .|.  . .   .|.    || ||. .. |.|      ..|. ......  |   ..|||||.. .|||.|||   . ..||| . . | 
eeeengkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
   .||.|||||||.||||..|.|..||..|  .... . ..|....|.|| ...||..||||....||.|.
stssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 55-318 4.4e-74 244.5 In-house 2-262 (263) alignment 
Range on Protein: 55-318
Range on HMM: 2-262/263.0
LRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
|..||  ... .  ....  .. ... |||||.. . ||.||||...    ..|||.||...........|.||.||.. ..||| |...|||  | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntdAKITETVFTVEGPGG-LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
. .|.| .|| .|.  . .   .|.    || ||. .. |.|      ..|. ......  |   ..|||||.. .|||.|||   . ..||| . . | 
eeeengkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
   .||.|||||||.||||..|.|..||..|  .... . ..|....|.|| ...||..||||....||.|.
stssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 55-318 5.9e-43 141.9 In-house 7-268 (274) alignment 
Range on Protein: 55-318
Range on HMM: 7-268/274.0
LRAEFAAMKRFNDFEKMKAFKeaqEHGKNRYKDVGCLDHNRVKLHPPWPH----DYIHANFVSTPSN-PRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
|..||  .    | |... |.   .. |||||..   .. || |..  ..    .|| ||..  ...  . .. || || .  |||| |  ||.|. | |
lekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

LCNIMEKGAKKCCDYFAckDKPVLEFEEKGHKIIVKFESTgkmkfEKNTDAKITETVFTVEGPgglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS
| .. |.  .||  ||   |.  .| .|.  .. .|.|..      .. | .... |          ..|. | . ||||. .|    ....|..... |
ltklkeaneqkCavyfP..daedyeiserygdveikveki.....verndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvlevees

-------KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
        .|.||||||||||||  . |.  . ||   . ..   ||  ..| .|   .||..|| ..|...  | 
reeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 55-318 1.2e-35 117.6 In-house 17-293 (301) alignment 
Range on Protein: 55-318
Range on HMM: 17-293/301.0
LRAEFAAMKRFNDFEKMKAFKEaQEHGKNRYKDVGCLDHNRVKLHPPWP-----HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
. ... ..|. .| . .  ..| ...  ||.|..  .|.||. |.|        ..|| |....  |. ..|| .|.|..|  .||| . .|||. || |
feeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivm

LCNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKFEST----------GKMKFEKNTDAKITETVFTVEGPGgLAQKVTQYHWIDWPDRGV---P-TA
..|  |.  .||  |.   ..   || .    . |.. ..           ..| .. .. . .|  | |.     ...|.|.. .|||. ||   | | 
vtnlkegtkskceqywpnseaeseefgp....ftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtv

DMAIVEL-LAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
 ..| .   .. ....|| |||||....|.|  . ..  |.|    . . .  .. . .| ..   ..| .|| ....||  | 
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 55-318 2.2e-24 80.9 In-house 8-259 (267) alignment 
Range on Protein: 55-318
Range on HMM: 8-259/267.0
LRAEFAAMKRFNDFEKM-KAFKEAQEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
.. ||  .|.  | .     .   . . .||. |.   |..|| |     ..|| | .| .    . || || ||... .||. .  ..||  | .| ..
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv

MEKGAKKccdYFackdKPVLEFEEKGHKIIVKFeStgkMKFEKNTDAKI-TETVFTVEGpgglAQKVTQYHWIDWPDRGVPTAD-MAIVELLAKTRPSKG
 .   ..   ..     | .   .| . . |.. |   .. |.|    |  |  |  |     |..|| |..  |            .. .||| .  .|
ftdnirl...fw....PPkmgqakkyqdltveh.s...lekeendyqiitlelkfknes....ahnvtlyyykkwnintnnkpylkplfgilaknqleng

--PTVVHCSAGIGRTGSVVMIEYILDQLLgGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
  | ||.||.|.||.|. ..|.  |...   ... .  . |.|||.||   ..| ..|...|... .| 
nrPlvvacsdGvGrsGtflvidsqlerak.tegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_PTPN13_pd Subfamily PTPN13 56-316 5.3e-47 155.4 In-house 14-267 (273) alignment 
Range on Protein: 56-316
Range on HMM: 14-267/273.0
RAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPhdYIHANFVSTPSNPRR--FICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
  ||  .. .   .. .  |..... ||||..|   |. ||||    .  || |...  | .  .  .| .| || ....||| |  . |.. | |. . 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

MEKGAKKCCDYFACKDKPVLEFEEKghkIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTR---PSK
 |||  ||  |.  . .  |  ...   . |. . .      .. |.    ..   .   | ...|.. ....||| |||.. . .....|. |    ..
kekgkvkchrywPesknkklkvsnr...levellkv......qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILN
|| ||||||||||.|... |. .|. .   ....   .|..|.||||.  .||..||.||...||.
gPivvhcsaGiGrsGtlitidvvlglierdkefd.vkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRA_pd Subfamily PTPRA 56-326 9.8e-44 144.6 In-house 35-304 (330) alignment 
Range on Protein: 56-326
Range on HMM: 35-304/330.0
RAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCN
| || |.   .    ... .. ... |||. ..   |..|| | .       ||| | |.    .  .|| .| |....  ||| |  . |  .| || .
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte

IMEKGAKKCCDYFAckDKPVLEFEEkghkIIVKFESTGKMKFEKNTDAKITetVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP----
. |.  .||  |.   |. .. . .    | |. | .  ..     .  ..    . .     .. |.|.|.  ||| |||.  . ...||.| .     
lkerkeekcaqywP..deGlvtyGn....irvevedetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq

SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK-MFDV
| || |||||||.||||. .... .|...   ....   ......| || . .|||.|| |...|.|.| |     .||
sagpivvhcsaGvGrtGtfivldavlervkaerkvd.vfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 56-318 1.3e-34 114.4 In-house 13-277 (287) alignment 
Range on Protein: 56-318
Range on HMM: 13-277/287.0
RAEFAAMKRFNdfEKM-KAFKEAQE---HGKNRYKDVGCLDHNRVKL--HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
 .|. |.|.    | .   ||.|.|     |||| ||  .|..|| |  ..    ||| ||.|..  .  .||..|.|.  .  ||| . |.... |. .
dkevdalkeds..esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit

LCNIMEKGAKKCCDYFACKDKPVLEFeekGHKIiVKFESTgkmkfEKNTDaKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIV----EL---
.   .|.. .||  |.  ...|..     |. . | .. .      |. .   . ..  ..  .  |. | |.....|||.... . ....    .    
mtreveearlkcykywPerevPmrvG...Gysv.vlldyd.....ikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqh

--LAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
  ||.     || |||...||||.| .. .  ....|.   ... . ... ..||.|.  .|.  |. .. . .  | 
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 58-322 9.2e-45 147.5 In-house 16-273 (281) alignment 
Range on Protein: 58-322
Range on HMM: 16-273/281.0
EFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
||. .      .   .|..  .  |||| .. |||  ||.|.   |     ||||||.. .|   | .| || |  .. |||| |  ||.  .| |||..
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

MEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntDAKITETVFTVEGPgglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPT
.|   .||..||  . . .|.|.    |. |..| .   |         |   .. ||    .. .|.. | .|||  || .   ....| | |    | 
letnrekcaeyfprnahcclqfd....klsvsyedstvnk.....slvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkirarstpp

VVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIRE-QRNNSIQTDQQYLFVHQVILNYCLDKK
|.|||||.||.|... .|  |. .     . .  .|. ..|   |  |.|| |||... .|.|.. .  |
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_eak_pd Subfamily eak 64-323 1.6e-14 48.1 In-house 34-310 (332) alignment 
Range on Protein: 64-323
Range on HMM: 34-310/332.0
RFNDFEKMKAFKEAQEH---GKNRYKDVgCLDHNRVKLHPPW--PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGA
 ..|...... .|..      .| .| |   |.. |.| .    .  || |  .  .   |..| | .. ..    || | |..|  .| .| . .|.. 
dlddyqrllsisetarleavnrnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

KKCCDYFACKDKPVLEFEEK--GHKIIVKFESTGKMKFEKNTDAKIT-ETVFTVEGPGGLAQKVTQYHW-I--DWPDRGVPTADMA-------IVELLAK
.|   ||  | . .|.|       |  || .     ..| .   .      ..| |   ..  . .    .     . ||.            ..    .
eksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyih

TRPSKGPtVVHCSAGIGRTGSVVMIEyILDQLLGGQQIE--ETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKM
| ||  | .. .. |  |.|  |.|. .| .|. ... .    .... |....|. |. ...|. |.....|.| | .. 
tppsfap.iiqsarGsaraGvfvvid.llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
subfamily_egg_pd Subfamily egg 66-320 3.4e-33 109.6 In-house 27-272 (307) alignment 
Range on Protein: 66-320
Range on HMM: 27-272/307.0
NDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgaKKCC
 | . ..   .. .  | | | | | |  ||||. .   .  |.|||| |.       ||..||||  .  ||| |  ||.|. | ||    |   ..| 
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

DYFACKDKPVLEFEEKGHKIivkfestGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWiDWPDRGVPTadmAIVELLAKTRPSKGPTVVHCSAGIG
 |.   ..  | .   . .|         .| ....|   . | . . |.    . .  . . |.   .        ...| | |    |.||..  |. 
yywpkaesdslvtvpGslri.......enlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvy...splrvlrklrnlskpvvvqdilGvs

RTGSVVMIEYILDQLLGGQQIE-ETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.....| ||  | .|| |        .  . .| .|. |...  .||||....| .  |
kaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_PTPN1_pd Subfamily PTPN1 67-316 2.8e-50 165.7 In-house 21-269 (290) alignment 
Range on Protein: 67-316
Range on HMM: 21-269/290.0
DFEKmKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
||.  .. |. .....|||.||   || |.||.     ||| |..|  .   |..| || || . .. || |  ..|  .. || ...||.  || .|. 
dfpt.reaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

CKDK-PVLEFEEKGHKIivKFESTGKMKFEKNTDAKITEtvftveGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS------KGPTVVHCSA
....   |..|.   |.  |. |. . .. .    ....           .......|.. ||| ||| .  | ...| | | |      .||.|.||||
qgeeekellledtklkv..kliseerksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa

GIGRTGSVVMIEYILDQLLGGQQI--EETDKILQKIREQRNNSIQTDQQYLFVHQVILN
||||.|...... .| ..   ...   .  | | ..|..|   ||| .|  | .. ||.
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPRK_pd Subfamily PTPRK 68-320 1.2e-47 157.3 In-house 32-279 (314) alignment 
Range on Protein: 68-320
Range on HMM: 32-279/314.0
FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY
||   | |. ... |||..|.   |. ||.|..       ||| |... .  .|. || || ||..  .||| . ..|.  || || ...|.|. ||. |
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

FACKDKpvLeFeekgHKIIVKFestgkmkFEKNTDAKITETVFTVEG---PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHC
.  . .    .     .| |..        | ...|..   .|.||    .    ..| |.... ||| .||.   ....|...    . ...|..||||
WPedte..v.y....gdikvel.......vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

SAGIGRTGSVVMIEYILDqLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
||| ||||  ..|. .|| ..  ... .  .. ...|... | ..| .|| |...|||. || 
saGaGrtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 68-322 4.2e-42 139.1 In-house 33-281 (315) alignment 
Range on Protein: 68-322
Range on HMM: 33-281/315.0
FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY
  . .. .| ... |||||..  ||..||||        .||| | .. .  . . .|..|.||. |  ||| | ||||| .| |. .  |    ||  |
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

FACKDKPVLEFEEkghkIIVKfestgKMKFEKNTDAKITETvftVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG----PTVVHCSAG
.  ..    || .    | |.      .. | .||. . .    |   .   ..|||... .|||.||.    ....|. . . ..|    . .||||||
wPdrkadsvefGs....ikve.....llsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaG

IGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.|||| |. |. ...|.  .. ..   ......|..|   .||...| |.....|.. | ..
vGrtGvvisidevvaqikrtrsvd.vfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_CG7180_pd Subfamily CG7180 70-320 2.2e-26 87.2 In-house 33-292 (296) alignment 
Range on Protein: 70-320
Range on HMM: 33-292/296.0
KMKAFKEAQEHGKNRYKDVGCLDHNRVK---LHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAkKCCDYFA
. ..  ...  .|||. .|   |.|||    |.     ||| | .| .   .. .| |.|| ...  .|| .  .|..... .|.. ..    .. .|. 
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp

CKDkpvlefEEKGHKIIVKFESTGKMKFEKNTDAKITETVF-TVE---GPGGLAQKVTQYHWIDWPD-RGVPTADMAIVELLAK-------T--RPSKGP
 |       .|.  .|.|.  .. ..   |    |.| ..  . |   .       |.....  |.    ||    |..||. .       .  .| .||
nks......keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP

TVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.||..| | .|.|  . |.  |...   ....   . ....|..|.. ... ..| .. .|.|.. | 
vvvvssdGasRsGvylaidanlelvekeeevdvF.eavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 70-156 1.1e-08 29.0 In-house 87-174 (244) alignment 
Range on Protein: 70-156
Range on HMM: 87-174/244.0
KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP-PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEK
 ||   . ..  |||      .| ||| |        || | ||        .| || ||  .  ||| | |. .|. . .|  . |.
vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 71-321 4.1e-48 158.5 In-house 46-293 (310) alignment 
Range on Protein: 71-321
Range on HMM: 46-293/310.0
MKAFKeaQEHGKNRYKDVGCLDHNRVKLHP--PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFack
..|.|  ..  |||| || |||  ||||.      .||||||.| |      |||.| ||...  ||| | .||. .||..||...|.|  ||  |.   
yeayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw...

dkPVLEFEEKGHKIIVKFESTGKMKFE--KNTDAKITETVFTVEGPGGLAQ-KVTQYHWIDWPDRGVPTADMAIVE--LLAKTRpsKGPTVVHCSAGIGR
  | |   |    | |   |    .||  . . . . . |   | |  | . .|.  .| .|||||||      |   |||. |  .|| |||||||..|
..pslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr..hgpcvvhcsagkdr

TGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.. || ... .|.|  |.... ....  ... .|   |||. |||....| . ..  .
lyvvvalklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifarge
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 71-327 2.4e-36 120.1 In-house 24-277 (283) alignment 
Range on Protein: 71-327
Range on HMM: 24-277/283.0
MKAFKEA-QEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVS---TPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
    . | ... |||....   | .||.|..  ..||| | |.       . ...| .|.|||.   ||| |  .||. .| || ...|   .||. |. 
dadiasadenkrknrnqeivpadqwrvelkse.srdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

CKDkpVLEFEEkgHKIIVKFEsTGKMKFEKN-TDAKITetvftveGPGGLAQKVTQYHWIDWPDRGV--PTADMAIVELL--AKTRPSKGPTVVHCSAGI
 .     .. |    . .. | |..  | .     .         .    .  .. |  ||| . |   .   .  ....   .|.  ||| |||||.||
krG..sedyGe..ftvtlrke.ttsnsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgi

GRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNY--CLDKKMFDVD
|||.  . .   ....|    . .  .... .||||   .|| .|| .||...|.   | | ..  ||
Grtavfiaasasvkdalte.svvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd
0037934 (Phosphotyrosine protein) phosphatases II 73-317 1.1e-60 200.6 In-house 4-241 (243) alignment 
Range on Protein: 73-317
Range on HMM: 4-241/243.0
AFKEAQEHGKNRYKDVGCLDHNRVKLhPPwpHDYIHANFVSTPsnPrRFICTQAPLDKSCAD----FWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAck
 ..  . . ||||.|. ..||.|||| ..  .|||.||..  .  | |.|.||.||.....|    || |. ......| ||.. .|.|..||. |.   
iallpenlsknrysdilpydhsrvkl.eg..sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

DKPvlEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG--PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTR------------PSKGPTV
..   ....    ..|.. |.          ...| .....|   ...| . |..||.. ||| |||.    ....| ..|            .|.||..
gev..tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl

VHCSAGIGRTGSVVMIEYILDQLlggQqiEETDKILQKIREQRNN-SIQTDQQYLFVHQVILNY
||||||.|||| .... ..|..|   .     .......||||.. ..|| .|| |.....| .
VHCsaGvgRtGtliaaylmllll...g..vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 74-235 1.1e-24 81.9 In-house 25-182 (297) alignment 
Range on Protein: 74-235
Range on HMM: 25-182/297.0
FKEAQE---HGKNRYKDVGCLDHNRVKLHPPW-PHDYIHANFVSTPSNPR--RFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAC
|  |.      ||||.|.   | .||||      .||| |..|  | ..   ..|..| ||...  ||| .  .. |  | |.... | | .||  |.  
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

KDKPvlefEEKGHKIIVKFESTGKMKFEKntdAKITETVFTVEgpgGLAQKVTQYHWIDWPDRGVPTA
 ..       |  ...|.| |.   .|..    ..||  .         ..|.   .. ||| |||. 
vvqe....rlkagdvvveflsstsdefdr...viltelqliyr...sesrvvrhvqflswpdhGvpsd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 75-318 9.5e-48 157.6 In-house 5-242 (250) alignment 
Range on Protein: 75-318
Range on HMM: 5-242/250.0
KEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKkCCDYFackdkP
|. |.. |||| |.  ||. || |..       ||| | |. . .. . || ||.|| ..  ||| | |.||...| || |. |.. . . .|.     |
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw.....P

VLEFEEKGHkIIVKFESTgkmkfEKNTDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-----KGPTVVHCSAGIGRTGS
| . |. |. . |.  |.     |. .| .... . . .      . | |.|.. |||.|||    |..||| | . |     ..| .|.||||.||.|.
vekaekyGd.vtvsllsk.....eefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
 . |. .|..|   ....   |.....|..| ..... .|| ||...||.. 
fiaidavlerlkkekvvd.vfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 75-319 6e-47 154.9 In-house 16-265 (270) alignment 
Range on Protein: 75-319
Range on HMM: 16-265/270.0
KEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVS-TPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdk
. |...  |||.|.    . ||.|..        || ||.|    ......|....||. .  .|| | ..||| .| |. ...||| |||  |..    
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...

pvlefeEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEgPGGLAQKVTQYHWIDWPDRGVPTADM------AIVELLAKTR-----PSKG-PTVVHCS
      |...|. ...     .. ... .     |  ..|   |  .... ... .|||.|||...        ....|.. |      .|. |..||||
......epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
||.|||| ........  |   ..  .. .|....|..| . .|. .|| |.......|. 
aGvgRtGtlialDiavrlLee.tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 75-320 6.7e-42 138.2 In-house 39-278 (515) alignment 
Range on Protein: 75-320
Range on HMM: 39-278/515.0
KEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKP
.|  .. |||||..  .| .||||   .    .||. | .. .  | . .|..|.|.. |  ||| . |||.|  | |. .  |    ||  |.  |   
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

VLEFEEkghkIIVKFESTgkmkfEKNTDAkITETVFTVEGPGglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG----PTVVHCSAGIGRTGSV
 ..| .    | |.  |.     |  |.. |  ..  . |    .. |||.|. .|||.|||    ... |. . . ..|    | ..|||||.|||| |
svkfGs....ikvelvsl.....eactgg.ikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv

VMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
. |. .. .   .. ..   .....||..|   .||..|| |.....|.. | 
isidsvvahakttrmvd.vfnfvtnirqkrpylvqtqeqyafiygavledllw
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 75-315 5.1e-33 109.2 In-house 4-238 (239) alignment 
Range on Protein: 75-315
Range on HMM: 4-238/239.0
KEAQEHGKNRYKDVGCLDHNRVKLHP--PWPH-DYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdk
|.  .. |||| ..   ||.|| |      || ||| |...     .|. .|.||  .  |. ||| |  ||.   | ||  ..|   ||| .|.     
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..

pvlefEEKGHKIIVKFEstgkmKFEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGS
       |  .. | .      | |  .|  |   |..  |     . | |||.  |||.|||    |.. |  |    . |   | |.|||||.||||.
.....tskycnlrvtlr.....ktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
...|. .| |    |.  .  . .. |||.|   .|| .||.|.|  .|
flvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl
0040439 (Phosphotyrosine protein) phosphatases II 76-320 1.2e-63 210.3 In-house 8-248 (249) alignment 
Range on Protein: 76-320
Range on HMM: 8-248/249.0
EAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPV
    . ||||.|. ..||.||||..    ...|||.|......  .||||.||.||.....||| |. .... .| ||.. .|.| .||. |.    . .
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggs

LEFeekgHKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP------SKGPTVVHCSAGIGRTG
||.    ... |.. |. .        ...| ......    |   .|......|||| |||     ..... . |       ..||..||||||.||||
ley....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

SVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
 .... ..|.||   ...   . .....|.||....|...|| |.....| ..|.
tfiaaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 76-317 3.7e-63 208.5 In-house 6-242 (245) alignment 
Range on Protein: 76-317
Range on HMM: 6-242/245.0
EAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPV
    . ||||.|. ..||.|||| |. .   .|||.|..|...  ...||.||.||.....||| |. .... .|.||.. .|.| .||. |.    . .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

LEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP-----SKGPTVVHCSAGIGRTGS
|....    ..|.. |. .       ....| ....|.  . .  ..|..||...||| |||. .  ....|   |      |.||..||||||.|||| 
ltygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNY
.... ..|.||   . .   .......|.|| ...||..|| |.....|..
fiaaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 76-316 5.8e-33 109.0 In-house 4-238 (239) alignment 
Range on Protein: 76-316
Range on HMM: 4-238/239.0
EAQEHGKNRYKDVGCLDHNRVKLHP--PWPH-DYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdkp
.  .. |||| ..   ||.|| |      || ||| |...     .|. .|.||  .  |. ||| |  ||.   | ||  ..|   ||| .|.      
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...

vlefEEKGHKIIVKFEstgkmKFEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGSV
      |  .. | .      | |  .|  |   |..  |     . | |||.  |||.|||    |.. |  |    . |   | |.|||||.||||..
....tskycnlrvtlr.....ktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

VMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
..|. .| |    |.  .  . .. |||.|   .|| .||.|.|  .|.
lvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 77-319 7.4e-38 125.7 In-house 23-256 (284) alignment 
Range on Protein: 77-319
Range on HMM: 23-256/284.0
AQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCnimekgAKKCCDYFACKDKpvl
 |.  |||. ..   |.|.|||..       ||| | |..   .. ..| || ||| . |||| |  . .. .| .|        .||..|.  | .   
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv...

efeEKGHKIIVKFESTGKMKFekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK------TRPSKGPTVVHCSAGIGRTGSV
   .| ..  || .|  . .        . .   . .|     .|..|.|.  ||| |||   . .. |. |          . . |||||||.||||  
...ikeerfkvkvdsveesee.....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

VMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
.... .||..   .|..   ......|.|||. .|   || |..  .|.  |
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 78-321 3.2e-39 129.8 In-house 49-287 (297) alignment 
Range on Protein: 78-321
Range on HMM: 49-287/297.0
Q-EHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVstPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNImEKGAKKCCDYFAckDKPVL
. .  |.|||..   | .||||.    .   ||. | ||  ..|  |.|.|| | . . |||| | |.|.|  | || .  ... |||  |..  || | 
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWs..dkgvt

EFeekGhKIIVKFESTGKMKfekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTAD--MAIVELLAKTR-----PSKGPTVVHCSAGIGRTGS
.|   | .. |. .|. . .        |  ..   .|     . | ||....|||. |.  |   ....|.   |      ..|| .|||.||.|||| 
tf...G.dvsvvllsvsere......GfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.. |. .. .    ....   ....|.|..| . .||..|| ||....|.. | .
lltidsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 78-316 1.7e-37 123.9 In-house 47-277 (439) alignment 
Range on Protein: 78-316
Range on HMM: 47-277/439.0
QEHGKNRYKDVGCLDHNRVKL--HPPWPH-DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAkkccdYFACKDKPVLe
 .. |||||||| .|| || |   |  ||  || ||..    ... .| ||.| .... ||| . ...|.  | ||.|..|        |. .... .  
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy.

feekgHKIIVKFESTGKMkfekNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELL-----AKTRPSKGPTVVHCSAGIGRTGSVVM
       |.|. .   ..       .     ||     .   . | |.|.| |||. ||.    ....|     |. .   || |||||||.||||... 
.....gdiavrvdrniel....pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiia

IEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILN
..  |.||   ....  . |.. .|.||.. .|.  ||.|... .|.
ldialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 78-326 2.9e-24 80.2 In-house 46-287 (303) alignment 
Range on Protein: 78-326
Range on HMM: 46-287/303.0
QEHGKNRYKDVGCLDHNRVKLHPpwpHDYIHANFVSTPSNpRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgAKKCCDYFACKDKPVLEFEE
..  |||. || |||| .|||       ||||...   |. .. | || || ...|||| | ...||  ...|    |   |   |.   ...  |.|||
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdsey.dklggdsvfprnqdflkfee

KGHKIivkfestGKMKFEKNTDAKITEtVFTVEgPGGLAQKVTQYHWIDWPDRGVPTAD-----M---AIVELLAKTRPSKgPTVVHCSAGIGRTGSVVM
.  ..       |..|  . .|      | .|   |     .  .|. .||   .|.            .  .| |  .|. |||    .| ||.|.  .
rsirv.......gefkrvelgdgwvlk.vlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

IEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDV
.|     |   |   .  | |...|. |  ..|   |. .|. .. .. ||. .  .
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickl
subfamily_ptpA1_pd Subfamily ptpA1 78-270 3.1e-21 70.6 In-house 46-249 (418) alignment 
Range on Protein: 78-270
Range on HMM: 46-249/418.0
QEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTpSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKD-KPVL
..  |||| ..  ..| ||.|.        ||| ||..   . |..||||| || .. |||| |  ....  | ||    |.   ||  |.  .     .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

EFEEKGHKIIVKFeSTGKMKFEKNTDAKI-TETV-FTVEGpggLAQKVTQYHWIDWPDRGVPTADMAIVELLAK-------TRPS---KGPTVVHCSAGI
    .| ...  . |   ..  .. . .| |  . .|.||    .. .|||..  |||. .|     . .||           ||   . | .||||||.
siygngnevfgty.svelveviqdpereiitrnirltfeg...etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRTGSVVMI
||||...  
grtgtfcta
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 78-151 8.2e-06 19.6 In-house 36-117 (347) alignment 
Range on Protein: 78-151
Range on HMM: 36-117/347.0
QEHGKNRYKDVGCLDHNRVKLHPP--------WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
..  ||| |||   |  || | |          .. || |  .      . .| || || ..  ||| |    ||  .  . 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
0045098 (Phosphotyrosine protein) phosphatases II 79-320 7e-65 214.5 In-house 33-274 (278) alignment 
Range on Protein: 79-320
Range on HMM: 33-274/278.0
EHGKNRYKDVGCLDHNRVKlhppwphDYIHANFVSTPsnPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckDKPVLEFeek
   ||||||. ..||.|||       |||.|......  |..||.||.||.. .|||| |. .... .| ||.. .|.| .||. |.   .. .|..   
nldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggslty...

gHKIIVKFESTGKMkfEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTAD--M---AIVELLAKTRP--------------SKGPTVVHCSA
 ... |...|.  .  .. |  ... | .||| ...   .||..|.. ||| |||. .  .    ..| . . .               |.||..|||||
.gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GIGRTGSVVMIEYILDQLlggQQIEETDKILQKIREQRNN-SIQTDQQYLFVHQVILNYCLD
|.|||| .|.. ..|..|   ..    .......|.||.. ..|. .|| |.....| . | 
GvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 79-325 3.7e-48 158.8 In-house 50-293 (301) alignment 
Range on Protein: 79-325
Range on HMM: 50-293/301.0
EHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEk
.. |.||. | |  .  |..        ||||...|. .|.|||.||.||.... ||| |. | .|. | ||.. .||  .|| .|.. | .  |. .  
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr.

gHKIivKFESTgKMKFEKNTdakiTETVFTV-EGPGGLA-QKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQ
 .||  | ... .. ..|..    ..  . | .  | .| . || | . .|.||||| . . . .|.   . |. | ||||||||||. . .  ||.  .
.fki..kiknk.elilnkki....skrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylare

LLGGQQIEETDkILQKIREQRNNSIQTDQQYLFV-----HQVILNYCLDKKMFD
..  ..|| |.  |...||.| |..|| .|  ..     ...| .| .| |...
veadptielte.alkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiye
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 79-315 2.6e-39 129.9 In-house 3-236 (237) alignment 
Range on Protein: 79-315
Range on HMM: 3-236/237.0
EHGKNRYKDVGCLDHNRVKLHPPW-PHDYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVlefe
.. |||| .. . ||.|| |. .    ||| |...      |...|..| ||. || ||| |  |||   | ||  ..|.  .|| .|.   |.|     
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa....

EKGHkIIVKFestgkMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELL----AKTR--PSKGPTVVHCSAGIGRTGSVVMI
  |  . | .      | |. .|  .   . ....     . . ||..  |||||||    |.. .      ...  .  || ..|||||.|||| ...|
aygv.ltvsl.....kkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

EYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
. .| |    ... .  . .. | |.|   ||| .||.|.||.||
damlrqake.kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
0049772 (Phosphotyrosine protein) phosphatases II 79-318 1.7e-36 121.9 In-house 46-280 (314) alignment 
Range on Protein: 79-318
Range on HMM: 46-280/314.0
EHGKNRYKDVGCLDhNRVKLhPP---WPHDYIHANFVSTPsnpRRFICTQAPLDKSCADF----------WYMCL--QEKVDSIFM--------------
 . ||||.|. . | |||.| |      .|||.|..|...   ..||.||.||.  . ||          | | |  . .|  | |              
nrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCNIMEKGakkccDYFACKDKPVLEfeekghkiivkfestgkmkfE-------KntdakitetvftvegpgglAQKVTQYHWIDWPDRGVPTA
       |......|     ..   .| . |.                    |                            . . .|..|..|| ..|. 
aAlgKtpllildgng.....neptaadlellk....................eelydpelf...................erlgikylripvpDgsapll

DM--AIVELLAKTrPSKGPTVVHCSAGIGRTGSVVMIEYILDQLlggqQIeETDKILQKIREQRN-----NSIQTDQQYLFVHQVILNYC
..  ...|.. .  . .||..|||.||.||||. | . |.. .|    ..   ...|. .|..|      ..|.. .||.|.....|.|.
edfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 79-162 9.2e-08 25.9 In-house 34-119 (332) alignment 
Range on Protein: 79-162
Range on HMM: 34-119/332.0
EHGKNRYKDVGCLDHNRVKLHPPWP-HDYIHANFVSTPSNPRRFICTQAPLDK-SCADFWYMCLQEKVDSIFMLCNIMEKGAKKCC
.   ||   . |.||.||.| |     |.  |..|   |.   .| .|||..  .   || |  . |   |... .| ||  .|. 
nmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
Y_phosphatase Protein-tyrosine phosphatase 81-316 2.8e-70 231.8 Pfam-A 3-235 (235) alignment 
Range on Protein: 81-316
Range on HMM: 3-235/235.0
GKNRYKDVGCLDHNRVKL-HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKG
 ||||||. . |..|||| . . |.|||.||.|.. .....||.||.||.....||| |..|||| .|.||.. .||| .|| .|.  ...     ... 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slty

HKIIVKFEstgkmKFEKNTDAKITETVFTVEGPGG--LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYI
..| |. .     . ||. ....| ......  ..    ..|.|.|. .|||.|||.   ....|. | . ||    ||.|||||||.||||..|.....
gdikvelk.....ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

LDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
|.||  ...  .  .|....|.||....|. .|| |....||.
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 81-316 2.8e-70 231.8 In-house 3-235 (235) alignment 
Range on Protein: 81-316
Range on HMM: 3-235/235.0
GKNRYKDVGCLDHNRVKL-HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKG
 ||||||. . |..|||| . . |.|||.||.|.. .....||.||.||.....||| |..|||| .|.||.. .||| .|| .|.  ...     ... 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slty

HKIIVKFEstgkmKFEKNTDAKITETVFTVEGPGG--LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYI
..| |. .     . ||. ....| ......  ..    ..|.|.|. .|||.|||.   ....|. | . ||    ||.|||||||.||||..|.....
gdikvelk.....ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

LDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
|.||  ...  .  .|....|.||....|. .|| |....||.
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 81-322 1.4e-45 150.5 In-house 3-175 (182) alignment 
Range on Protein: 81-322
Range on HMM: 3-175/182.0
GKNRYKDVGCLDHNRvklhppwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCnimekgakkCCDYFAckdkpvlefeekgh
 ||||.|. . ||.|       . |||.||..  .  ..|||.||.||....|||. |  .... .| .|.         .. |..              
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............

kiivkfestgkmkfekntdakitetvftvegpGGLAQKVTQYHWIDWPDRGVPTaDMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQllgg
                                  | . ..||... ||| |||.    ..... . . ..||..||||||.||||..|.. ... .    
................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl....

qQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
 .    ..... .|..|.....| .|| |.....| ..| ||
.g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 81-321 3.3e-36 119.7 In-house 37-273 (285) alignment 
Range on Protein: 81-321
Range on HMM: 37-273/285.0
GKNRYKDVGCLDHNRVKLHPpWPHDYIHANFVSTPSNP-RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKG
  ||| || |..  || |.    .|||||...  | .    .| || || .. .|||.|  |||.  ..||| ..| | .||. |.  |   |..| .  
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye

HKII-VKFESTGKMKFEKNTdakITETVFTVEGPggLAQKVTQYHWidWPDRGVPTADMAIVELL---AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILD
  .  .| |.     ..  |   ...|  .   |  |  .  |  |  |||.  |     ..||     |  | . | .||||||.||| ..| |.|   
itlteckeeaiagtilnalt...vintedassep..lymnhvqvpw..wpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

QLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
...   .||  | |....|  | ...|.  |.||.. |...| . .
rimenpniemld.ivremramrfqavqshmqflflyvvlmeyfige
0044763 (Phosphotyrosine protein) phosphatases II 91-320 5.1e-30 99.8 In-house 2-173 (178) alignment 
Range on Protein: 91-320
Range on HMM: 2-173/178.0
LDHNRVKLHPPWP---HDYIHANFVStpsnPRRFICTQAPldkscADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvlefeekghkiivkfe
||..||.|...      |||.|...     |. ..... |     ||.. .  ......| .|.. .| |  ||. |.  .                   
ldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

stgkmkfekntdakitetvftvegpgglaqkvTQYHWIDWPDRGVPT---ADMAIVELLAKTR-PSKGPTVVHCSAGIGRTGSVVMIEYILDQllggqQI
                                 ||..| .|| |||.     ...||.. . . ...||..||||||.||.|..|.. ... .     ..
................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl

eETDKILQKIREQRNnSIQTDQQYLFVHQVILNYCLD
   ..... .||.|.  .... |. ..... | ..  
.sleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 93-189 5.9e-08 27.1 In-house 7-89 (130) alignment 
Range on Protein: 93-189
Range on HMM: 7-89/130.0
HNRVKlhppwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgakkcCDYFaCKDKPvLE-FEEkghKIIVKFEST
 .|..      ..||.|.||    . . .. ||.|| ... ||| | |.  |. . .|  . |.      .|.    .| || .||   .|||     
vsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deyw.pdseP.lewyee...diivtltdr
0046846 (Phosphotyrosine protein) phosphatases II 97-317 3.4e-40 133.0 In-house 5-172 (176) alignment 
Range on Protein: 97-317
Range on HMM: 5-172/176.0
KLHPPWPHDYIHANFVSTPsnprRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdkpvleFEEKGHkiivkfestgkmkfek
.|..... |||.||.. ..    |.|.||.|| ...|||. | ...... ...|.. .|.|  ||..|.         .|. |.                
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.......leklgi................

ntdakitetvftvegpgglaqkvtQYHWIDWPDRGVPTAD--MAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQIEETDKILQKIR
                        ||....||| |||. .  . ..|.. . . ..||..||||||||||| .|..  .       ..    ...|...|
........................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvr

EQRN-NSIQTDQQYLFVHQVILNY
|||  ...||..|| |.....| .
eqRplgavqtpeQyrflyefelll
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 102-320 8.7e-30 98.8 In-house 44-261 (290) alignment 
Range on Protein: 102-320
Range on HMM: 44-261/290.0
WPHDYIHANFVSTPSNpRRFICTQAPLDKS-------CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCdyFACKDkpvleFEEKGHKIIVKFESTGKMKF
   ||||||.|. |..  |.| ||.|. |          .||.|  ||||... |||. .|| |..    |||.      .  .    ..||.       
fnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl..faCak.....YvpesvgeelkfkgltvkCk

EKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIR
.| ..  . .   .|.  ..   .|| .   .| .. |.     ...|. | . || | .|||  || |   .  |.     . . ..  .. ..|...|
skekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr

EQRNNSIQTDQQYLFVHQVILNYCLD
.||.. |...... ||  .|. .  .
kqralaitsalelafvdagivllaie
0043147 (Phosphotyrosine protein) phosphatases II 104-312 2.1e-39 130.3 In-house 5-155 (172) alignment 
Range on Protein: 104-312
Range on HMM: 5-155/172.0
HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNImekgakkccdyfackdkpvlefeekghkiivkfestgkmkfekntdakit
.|||.|......  |.|||.||.||.  .|||| |. ..... |..|..                                                   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

etvftVEGPGGLAQKVTQYHWIDWPDRGVPtADMAIV---ELLAK--TRPSKGPTVVHCSAGIGRTGSVVMIEYILdqllG-GqqieETDKILQKIREQR
     .  | .| . . ||... ||| |||     .    |.. .   . ..||..||||||.|||| .|.. ..|             ..... .||.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl....sleeavalvrekR

NNSIQTDQQYLFVHQ
....|...|| |...
pgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 104-312 2.5e-39 130.1 In-house 2-164 (174) alignment 
Range on Protein: 104-312
Range on HMM: 2-164/174.0
HDYIHANFVSTPSNPRRFICTQAPLDkscadFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdkpvlefeekghkiivkfestgkmkfekntdakit
.|||.|....    ..|.|..|.||.     ||.|. .... ...||.. .|.|  ||..|.                                      
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

etvftveGPGGLAQKVTQYHWIDWPDRGVPTADMaIVELLAKTRPS-----KGPTVVHCSAGIGRTGSVVMIEYILDQLLggQQIEETDKILQKIREQRN
        .  | . . ||... |||.|||. .. . |..   .       .||..||||||.|||| .|.. ..| .||  .  ..  ......| || 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp

NSIQTDQQYLFVHQ
...||..|| |...
gmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 104-314 3.3e-29 96.8 In-house 3-149 (151) alignment 
Range on Protein: 104-314
Range on HMM: 3-149/151.0
HDYIHANFVSTPsnprrFICTQAPLDkscaDFWYMCLQEKVDSIFMLCNIMEKGakKCCDYFACKDkpvlefeekghkiivkfestgkmkfekntdakit
 |||....|        ......||.    ||. .  ......|..|.. .| |  .| .|.   .                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

etvftvegpgglaQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-KGPTVVHCSAGIGRTGSVVMIEYILDQllggqqiEETDKILQKIREQRNNSIQ
              .|......|||| |.|.   |..|.| . .   .||..||||||.|||| .|..  .| .          ...|. .|..| ...|
.............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq

TDQQYLFVHQVI
. ||.||.....
pnqqflfqlfal
subfamily_CG42327_pd Subfamily CG42327 104-249 1.2e-17 58.6 In-house 56-193 (319) alignment 
Range on Protein: 104-249
Range on HMM: 56-193/319.0
HDYIHANFVSTP-SNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvlefeEKGHKIIVKFESTGKMKFEKntDAKI
  |..|..|  . . |  .|..|..|..| .||| .  . .   |  |... |.| |.| .|.  |.        ....   ..  | | .  |  |  .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket......ldntslyGdilvtlkgrevk..drya

TETVFTVEGPGGLAQKVTQYHWiDWPDRGVPTADMAIVELLAKTRPS
. |.   .  . .....| | . .|.. .||. . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0051429 (Phosphotyrosine protein) phosphatases II 105-332 2.9e-45 150.3 In-house 5-239 (272) alignment 
Range on Protein: 105-332
Range on HMM: 5-239/272.0
DYIHANFVSTPSN---PRRFICTQAPLDKSCADFWYMcLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEK-GHKIIVKFESTGKMKFEKNTDA
.||.|..|... .   |.|......||. ..||||..  ......|..|.. .|.|. ||  | .  .  .| ...     | . . .   ...|  .| 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

KITETVFTVEGPGGLAQKVTQYHWIDWPDRGVP-TADMAIVELLAKtrpsKGPTVVHCSAGIGRTGSVVMIEYILdQLLGGQQIEE--------TDKILQ
 ..| . | . . | | .|...|..||||.|||  |  ...|||..    .|| .||||||..||| ||.. ..| . .. ..| .         .....
ilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeave

KIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAH
..|.|| ...||..||||.....|..       .... ||.
elraqrpgavqteeqylflyeallellrsllsvraeyllaa
0049260 (Phosphotyrosine protein) phosphatases II 116-312 1.8e-34 114.0 In-house 6-144 (152) alignment 
Range on Protein: 116-312
Range on HMM: 6-144/152.0
SNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkpvlefeekghkiivkfestgkmkfekntdakitetvftvegpggl
 .|..||.||.|.. ..|||| |  . ... | ||.. .|.|  ||  |.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

aqkvtQYHWIDWPDRGVPTADMAIVELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILdqllggqQIEETDKILQKIREQRNNSIQTDQQYLFVH
     ||... ||| |||. .. . .||       . ..||..||||||.|||| .|.. ..|       .  . ..... .||.|...... .|. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

Q
.
e
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 119-313 8.6e-09 29.8 In-house 4-198 (198) alignment 
Range on Protein: 119-313
Range on HMM: 4-198/198.0
RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNiMEKgaKKCCDYFACKdkPVLefeEKGHKIIVKFESTGKMKfEKNTDAKITETVFTVEGPG-GLAQ
||.|.|| || .. |||| |  .     | |. .  .|  .| .||      |.    | |      .  | |     . |  ||  ..| .      ..
rryiatqhplretladfwqmvwetgsghivmvnd.dqk..nkeadypfyw..ptt...esgtgkygslsvttkti.ttkpdytitaliltnnttappstr

KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK-------GPTVVHCSAGIGRTGSVVMIEYILDQL-LGGQQIEETDKILQKIREQRNNSIQTDQQYLF
....| .  | ..  |   . .  ..|    ||        | .|||| | | ||  | ..  .         . .  .. ...|. |   | . |.| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

VHQV
..||
iyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 119-313 9.1e-09 29.8 In-house 5-199 (199) alignment 
Range on Protein: 119-313
Range on HMM: 5-199/199.0
RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNiMEKgaKKCCDYFACKdkPVLefeEKGHKIIVKFESTGKMKfEKNTDAKITETVFTVEGPG-GLAQ
||.|.|| || .. |||| |  .     | |. .  .|  .| .||      |.    | |      .  | |     . |  ||  ..| .      ..
rryiatqhplretmadfwqmvwetgsghivmvnd.dqk..nkeadypfyw..ptt...esgtgkygslsvttkti.ttkpdytitaliltnnttappstr

KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK-------GPTVVHCSAGIGRTGSVVMIEYILDQL-LGGQQIEETDKILQKIREQRNNSIQTDQQYLF
....| .  | ..  |   . .  ..|    ||        | .|||| | | ||  | ..  .         . .  .. ...|. |   | . |.| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

VHQV
..||
iyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 127-320 1.1e-23 78.2 In-house 99-290 (302) alignment 
Range on Protein: 127-320
Range on HMM: 99-290/302.0
PLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIvkfeSTgKMKFEKNTDAKiTETVFTVEGPGG-----LAQKVTQ
|  ...  .| .  | .|  .  ||...|.. ||| .|.. | . .|.| .   | .    |  | ..|. || | . ...|||         . . |  
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktv....sv.ktdleeftdkk.sfklytveiknekkkkkvkktvdi

YHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILdQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
 ..  ||| | |    . ...|      |   .||||||.||||..| | | . ||   ... .  .|.. .|. |  ..|..|| ...  ..    ..
lafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme
subfamily_hpo-7_pd Subfamily hpo-7 130-321 4.5e-17 56.8 In-house 45-230 (263) alignment 
Range on Protein: 130-321
Range on HMM: 45-230/263.0
KSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckdkpvLEFEEKGHKIIVKFESTGKMKfekNTDAKITETVFTVEGpGGLAQKVTQYHWIDWPD
.  . |. .  | | . . |||.  |.| .||  ||       || .||     |.  .|  ..   ..  |  | . |..      ..|..| .  |..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfP......lekdekqklanvnvcttkvqs...dvllktlellstlge.KkkthtvkhysykgWie

RGVPTADMAIVELLAKTRPSKgPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD-----KILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.  |.    |...|  .| || . |||||.||||. . ...| .  ...   .  .|      ..|...|..|. .|.|  |  |   ..|.. |. 
kndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 131-325 9.5e-20 65.7 In-house 40-228 (255) alignment 
Range on Protein: 131-325
Range on HMM: 40-228/255.0
SCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkiiVKFESTGkmkfeKNTDAK-ITETVFTVEGPGGLAQKVTQYHWIDWPD
. . |. .  | | . . |||.  |.| .||  ||  .    | ...      |.  .|        .|    | .. .  |    ...|. |..  |..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad......vnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGWie

RGVPTADMAIVELLAKTRPSKgPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD-----KILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMF
.  |     | ..|   | || . |||||.||||. . |..|..  ...   .  ||      ..|...|..|. .|.|  |  |   ..|..   |. .
knaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgel

D
.
e
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 132-321 1.7e-06 20.9 In-house 131-312 (346) alignment 
Range on Protein: 132-321
Range on HMM: 131-312/346.0
CADFWYMCLQEKVDSIFMLCNiMEKGAKKCCDyfackdkpVLEFEEKGhkiivkFESTGKMKFE-KNTDAKITETVFTVEG-PGGLAQKV-TQ-YHWIDW
  |||||  ||... ....    .|  .            ... |. |      .. ||||  . . .|       .|.|  | | .. |  | .|   |
vedfwymiyqeqihlvylmvp.ddklknttts........lfndengg......yqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapw

PDRGVPTADMAIVELLAKT-----RPSKGPTVVhCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
     |   . |. .. .        . |  ||    | ||. | .   | ..||  | . .   .|...|..||  ....  ||  .. ....|   |
khlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepn.iceimknikqqrpggvesfaqyasiyaivfdyiark
0048179 (Phosphotyrosine protein) phosphatases II 175-312 3.4e-21 70.9 In-house 25-139 (144) alignment 
Range on Protein: 175-312
Range on HMM: 25-139/144.0
FEEKGHKIIVKFESTGKMKFEKNTdakitetvftvegpgglaqkVTQYHWIDWPDRGVPTA---DMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIE
. . |.. .. . ..  . |....                    ..||....|||.|||.      ...|.. . ....||..||||||.||||..|.. 
lkklgittvinlteeyepeflere....................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

YILdqllgGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQ
 ..      ..    ...|. .|..| .......|. |...
lmk.....klg.lsleealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 202-316 1.2e-22 75.5 In-house 30-141 (145) alignment 
Range on Protein: 202-316
Range on HMM: 30-141/145.0
ITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTA---DMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQiEETDKILQKIREQRN
||  .     . .| ....||....|||.|||.     ....|.. . ....||..||||||.||||..|..  .|      ..    ...|...|.|| 
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrp

NSIQTDQQYLFVHQVILN
.......|. |.....| 
gavpnpgqlrflyefele
subfamily_PTPDC1_pd Subfamily PTPDC1 204-314 1.1e-11 39.5 In-house 68-172 (182) alignment 
Range on Protein: 204-314
Range on HMM: 68-172/182.0
ETVFTVEgPGGLAQKVTQYHWIDWPDRGVPTADM--AIVELLAKTrPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLggqqieETDKILQKIREQRNNSI
|. |. . .  |...   .. . |.| ||.. .    || ..| .  ..| . ||| || |||| ..    .  . |      ...| ....|..| .||
esGfsYd.lealmeqgiyvynfgwkDygvasleriLdivkvvafa.lqegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksi

QTDQQYLFVHQVI
|| .|  .|..  
qtreqvelvkefa
subfamily_PTPRN_pd Subfamily PTPRN 217-314 3e-18 60.6 In-house 187-288 (297) alignment 
Range on Protein: 217-314
Range on HMM: 187-288/297.0
QKVTQYHWIDWPDRGVPTADMAIVELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQ
. |||.|.. ||..|||..  ...|.  |     |    | |||||.| ||||  ..|. .|..|| | .  .    |...|.||.. ..| .|. |. .
rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt

VI
..
av
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 217-323 6.1e-17 56.1 In-house 89-201 (440) alignment 
Range on Protein: 217-323
Range on HMM: 89-201/440.0
QKVTQYHWIDWPDRGVPTADMAIVELLAK-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVH
. . |||.  |||.|||     .....        . ..|| .|||||| |||| .. .. || .    .||.    ... .|..| . .|| .|| |||
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyafvh

QVILNY--CLDKKM
...|.   | |  .
eavlegllcgdtli
PTPc_DSPc_SM00012 218-315 4.2e-29 96.2 In-house 1-104 (105) alignment 
Range on Protein: 218-315
Range on HMM: 1-104/105.0
KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG------PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVH
.|..||. .||| |||.   .|.|||.... .|       |.|||||||.|||| .|.....|.||  ...  .  .|....|.||....||..||||..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QVIL
...|
rall
0038934 (Phosphotyrosine protein) phosphatases II 218-311 9.4e-09 30.7 In-house 78-170 (194) alignment 
Range on Protein: 218-311
Range on HMM: 78-170/194.0
KVTQYHWIDWPDRG-VPTADMAI-----VELLAkTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllGGQqieETDKILQKIREQRNNSIQTDQQYLFVH
   .|. . .||.| ||. ..       |.     . ..|  .||| ||.|||| .|    |      |      .. .. .|| |...|.. ...  ..
agieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr...lgm...saeeAialfrekRpgaipnqdyleall
PTEN_1 220-269 1.3e-08 29.9 In-house 95-149 (196) alignment 
Range on Protein: 220-269
Range on HMM: 95-149/196.0
TQYHWIDWPDRGVPTADMAI--VELLAKTRP---SKGPTVVHCSAGIGRTGSVVM
 .|. ....| |.|. .. .  .. ..  .    ...  .||| ||.||.| ||.
veylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_DSP19_pd Subfamily DSP19 225-299 8.7e-07 23.4 In-house 64-132 (152) alignment 
Range on Protein: 225-299
Range on HMM: 64-132/152.0
IDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDqllggQQIEETDKILQKIREQRNN
.| |.  . .   .... . ..| ..|  .|||.||. |. ||| | |..      ..  .. . |...||.| .
lDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iaylmk.....keelsleealelvrearpc
subfamily_CDKN3_pd Subfamily CDKN3 225-312 1.2e-06 22.3 In-house 105-190 (202) alignment 
Range on Protein: 225-312
Range on HMM: 105-190/202.0
IDWPDRGVPT--ADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVmiEYILDQLlgGQQIEETDkILQKIREQRN-NSIQTDQQYLFVHQ
   .| .||   . . |.| |  .  .   |.|||  |.||.  |.    .|  |   ..||  |  ..|.|. .  ..||| .|| ....
ypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslvi..aclllyl..ddtiepkd.aidklrdlkgsraiqtvkqynylse
subfamily_DSP23_pd Subfamily DSP23 225-312 6.8e-06 20.8 In-house 57-140 (148) alignment 
Range on Protein: 225-312
Range on HMM: 57-140/148.0
IDWPDRGVPTADM--AIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQIEETDKIlQKIREQRNNSIQTDQQYLFVHQ
.  .|   |. .    .|... ..   .    |||  | ||||...   ..       ...  .. |  ..|..|  |..| .|   |..
lriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvke.....rklaaaeai.aevrrlrpgsvetveqeklvrd
subfamily_CDC14_pd Subfamily CDC14 231-312 2e-06 21.9 In-house 245-320 (328) alignment 
Range on Protein: 231-312
Range on HMM: 245-320/328.0
GVPTaDMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIeYILDQLlggqQIEETDkILQKIREQRNNSIQTD-QQYLFVHQ
..|. |. . ..|. .  ..|  .||| ||.||||...   |.. .     ..  .. ..  .|  |  |. .  |..|  .|
stPs.daivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkhy....rftaae.aiawlricrPGsvigpqqkfleekq
DSPc Dual specificity phosphatase, catalytic domain 239-294 1.4e-06 23.2 Pfam-A 62-114 (133) alignment 
Range on Protein: 239-294
Range on HMM: 62-114/133.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDQLlgGQQIEETDKILQKIR
.|| ..| . ...  .||| ||| |..... | |....   . ...|  ..... |
avefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktk..nlslneAyefvkerr
DSPc Dual specificity phosphatase, catalytic domain 239-294 1.4e-06 23.2 In-house 62-114 (133) alignment 
Range on Protein: 239-294
Range on HMM: 62-114/133.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDQLlgGQQIEETDKILQKIR
.|| ..| . ...  .||| ||| |..... | |....   . ...|  ..... |
avefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktk..nlslneAyefvkerr
PTPc_motif_SM00404 239-276 2.8e-06 22.3 In-house 69-106 (140) alignment 
Range on Protein: 239-276
Range on HMM: 69-106/140.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQ
... . . . ..|  .||| ||. |...... ...  .
vldfienaekkggkvlVHCqaGvSRSatliiaYlmryr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 240-316 1.5e-16 55.2 In-house 218-293 (297) alignment 
Range on Protein: 240-316
Range on HMM: 218-293/297.0
VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLlGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
.| |    | . ...||||||.||.| ||. . ||..|   ..| ..  ||...||||   .|| .|. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilakl.rkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_PTPN9_pd Subfamily PTPN9 245-322 1.4e-19 65.3 In-house 218-294 (297) alignment 
Range on Protein: 245-322
Range on HMM: 218-294/297.0
KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| .||. | ||||||||||||  . ... |..|   ....   . ....|.||  ||||..|| | .. .|.| | .|
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvd.vvetvkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_CG42327_pd Subfamily CG42327 246-318 1.4e-13 45.2 In-house 243-315 (319) alignment 
Range on Protein: 246-318
Range on HMM: 243-315/319.0
TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|| |.|| ||||| |.|||| |.  .  . .|   ..  .  .... .|..| ....| .|| |...|. .|.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 249-315 2.7e-07 24.5 In-house 270-335 (347) alignment 
Range on Protein: 249-315
Range on HMM: 270-335/347.0
SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
 . | || |  |. |. .||.   |..|.| |.   . |....|.|.||   .     | .  .  |
klapvvvmcdlgldrsatvvltsiiieqvldgkt.pdcddlfkkmrdqragvftmsifytyairaal
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 251-318 1.6e-09 31.9 In-house 263-344 (350) alignment 
Range on Protein: 251-318
Range on HMM: 263-344/350.0
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEE-----------TD---KILQKIREQRNNSIQTDQQYLFVHQVILNYC
 | .||||||.|||| .| ....| ...  .....            |    |....|.|| . .|. .|..|... .|.| 
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 251-318 1.1e-06 22.3 In-house 266-344 (349) alignment 
Range on Protein: 251-318
Range on HMM: 266-344/349.0
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQ----QI----EETDKI---LQKIREQRNNSIQTDQQYLFVHQVILNYC
 . .|||||| |||| .| ....|. |   |    .|       | |   . ..| || . .|  .|. .... .|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_PTEN_pd Subfamily PTEN 253-311 3.6e-06 22.1 In-house 117-173 (184) alignment 
Range on Protein: 253-311
Range on HMM: 117-173/184.0
TVVHCSAGIGRTGSVVmIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVH
 |||| || |||| .. . |.| .||  .. ||. .. ...| . .....   |  .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve