Gene ZK616.65 in Caenorhabditis elegans

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf13
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP238_AA protein Get Run
CeleP238_AA_246-521 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 235-512 3.1e-27 90.0 In-house 3-276 (303) alignment
Range on Protein: 235-512
Range on HMM: 3-276/303.0
EETREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPgdpPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKvmpnknSTDYIHANYIRSPFLKRGyILTQG
|| .. .. | |..     ... ..|..  | ||   ||     | .  | .|||. .. ||| |.|.|        . ||||.|.     |.  |||| 
eekkqkwkllakrtldedaniavnefekvvsylp...psvsknqfvk..nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltql

PKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHcCLQFDKMSVS---YEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGS
|   | ||||.|| ...   ...|   .| ..      ||||    |.|.. |.    .    . .  |   | .|      ..    .|.||  ..|. 
plshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsd

-SEVMLK-------ILRKIrARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
 |  ..|       .|||  . |||.|    .|.||.||.   | |  |.||  .  |. . .  .|  ||  .|| | |. ... .| 
gspkfvkqiwqlqsvlrky.sdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvr.ngrlhavqnlsqfsvvytlla

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 237-525 1.1e-42 140.7 In-house 6-300 (310) alignment
Range on Protein: 237-525
Range on HMM: 6-300/310.0
TREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDL-CTAFNQpvNNKKNRYLNIPCLDISRVQLKVMPNKnSTDYIHANYIRSPFLKRGYILTQGP
    | | ...| ....|. .. . ... .|  .  | |   |...  . .|||| .. ||| |||.||.   .   |||||||... .|.  .| .|||
hhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgp

KKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPR----NAHCCLQFDKMSVSYEDSTVNKSLVTT-RLNLSYEGE-----TRLITHWLWKEWPD
 . |  ||||||.|| . .|..||. .|  | ||  |.|     ... |..  ..| | |.  . .  ||    |.  . .        ..   | .|||
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

WQVPGSS--EVMLKILRKIraRSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQITE
  ||      |  ..| ..  |  | |.|||||..| ....|...... ..      |.......|.   ||  .||  ||..| .| . |  . ....|
rgvpdekchtvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrg.lkvdaeevktellk.sraiciqtelqyliidrvriifargetevae

EL
..
ki

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 238-514 4.8e-56 185.2 In-house 7-289 (298) alignment
Range on Protein: 238-514
Range on HMM: 7-289/298.0
REAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPP---SDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQG
 | ...... .|  ..|..|  ...|| .|        ..  .. ..| |.||||| .|  || ||| |. . ... .||| | .. .   .  .|.||.
aedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqa

PKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHccLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSS
| .|| .|||||...|. ..|||| . .|... |. .|.| . .   ......||   . .   |....|..| .   ..| . .  . .||| .||  .
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena

EVMLKILRKIRARS-----TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
. .|..|||.||       .| ...|||||||||| .|..  |. ..   .. |. |.|  ||.. |...||| .||. |... |..
tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkk.rpgavqteeqYvfiyeavlea

subfamily_PTPRB_pd Subfamily PTPRB 240-514 8.8e-69 226.7 In-house 7-284 (293) alignment
Range on Protein: 240-514
Range on HMM: 7-284/293.0
AYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKET
   . |... .. .. .   |..|...|     .  ..| ...||..|||| ||   | |||.|. . .....||| ||||.    .| .| ||||  ||
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

RADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCClQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKIL
. |||||.|......|||| |  |  ..|| ||.|.. . . .. ...|.   ... .  |.  |... | |.| .... .. |||. || ... .|...
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfv

RKIRARS------TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
|..| .       .| |.||||||||.||..|..  ||.|... .. ||  ||..|| . |.  ||| .||. | ...||.
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyv.difgivaelRee.RnllvqtekqYifihqcvldl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 243-521 1.8e-58 192.5 In-house 12-289 (290) alignment
Range on Protein: 243-521
Range on HMM: 12-289/290.0
KLFKDFAMSSQKMTLDDFKQEFSN--LPGDPPSDL-CTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpNKNSTDYIHANYIRSpfLKRGYILTQGPKKET
. |. || .  |.. |.. .|. .   |  |   |    |..  . ||||| ...| |..|| ||   .    ||.||||..   ||  .|||||. |.|
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkG..lkamfiltqGalkdt

RADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTR-L--NLSYEGETRLITHWLWKEWPDWQVPGSSEVML
  |.|||. ||...||||||.  |  . ||..|.| ..   | | ...|    .. . . .  . |      .|    . |.  | |||  |. |.  .|
vidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

KILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQI
..|| .|  | | |.|||||.||.||..|.|..|| .     | |. ..|  ||   |..|||   ||... ..|||.|...| |
rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkel.dlldlvralrn.srlnsvqvdiqylalveilldlGkdfkyi

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 243-533 3.6e-42 139.3 In-house 5-299 (439) alignment
Range on Protein: 243-533
Range on HMM: 5-299/439.0
KLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTA--FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETR
. |..     .|   . ||..| ..    |   | |    |  .. |||| ..  .| .|| |. .|    . || ||||.  . .. || |||||||| 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

ADFWRMIWQENTTAIVMLCQFTETNRekcaeYFPRNAHCCL-----QFDKmSVSYEDSTVNKSLVTTRLNLSYegETRLITHWLWKEWPDWQVPGSSEVM
 ||||......|. ||||... |. .     |.| .|..|      . |.  .   . ..    |  . . .     | . .. .  ||| .||  .  .
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdr.nielpnyvirgfkvfnerdtte..kertvlqfhyiawpdknvpaqashv

LKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDfGVAYKQITEELAE---
|. || | .        | |.||||||||.||..|..|||. ...   . ||| ||. ||   |   ||.| ||..|.. .|.  . | .|.  . |   
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkv.dikgivkvlrk.qrkqmvqalcqyvfiynavle.divyGdiavtidefkk

KFNATY
.||| .
efnagf

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 245-513 4.6e-48 158.6 In-house 7-281 (290) alignment
Range on Protein: 245-513
Range on HMM: 7-281/290.0
FKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNS--TDYIHANYIRSPFLKRGYILTQGPKKETRAD
| .| .  ..   . |...|  |     .   |  . . |...||. ||   |  |. |. .....    .||.| ||     |. ||.|||| ..| .|
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCClqFDKMSVSY-EDSTVNkSLVTTRLNLSYE---GETRLITHWLWKEWPDWQ-VPGSSEVMLK
||..||||..|.||||.. .| ...||  |.| .      ....|.   ...|.| . ....|..  .   |... .|..  . |..   |.  . ..| 
FWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

ILRKIR----ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
| . ..       |. |.|||..||||....|......  ..     |. |.. ..|.  .  |||| ||| .| ...| 
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi.dvfqvlksqRiq.kpgsvqtvqqyqgifqivlt

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 245-514 2.3e-45 149.8 In-house 7-277 (287) alignment
Range on Protein: 245-514
Range on HMM: 7-277/287.0
FKDFAMSSQKMTLDDFKQEFSNLPG-DPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADF
| .|. . ..   ..||. |  |   .   |  |    . |..|||. .|   |  || ||    ..  ||| | .| .   |. .|....|  .|  .|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHccLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG---ETRLITHWLWKEWPDWQ-VPGSSEVMLKIL
|..|...| |||||||| .|...|.| .|.| ..   . . . ...  . .||.. .  .|..  ..   ... .. .   .|..   |.    ..| | 
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

RKIRAR----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
......     |. |.|||..||||....|......  .   .. |. |.. . |.  .  |||| .||. | ...| .
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGvi.Dvfqvlksqriq.kpgsvqtveqykfindivley

subfamily_PTPRD_pd Subfamily PTPRD 246-514 7.4e-71 234.5 In-house 11-280 (564) alignment
Range on Protein: 246-514
Range on HMM: 11-280/564.0
KDFAMSSQKMTLDDFKQEFSNLPGDpPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWR
|..  . ..    .|..|. ..    ..  ..| |.|.| .|||| ||   | ||| |. .......||| |..| .   .. || ||||..|| .||||
kehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWR

MIWQENTTAIVMLCQFTETNREKCAEYFPRNaHcCLQFDKMSVSYEDSTVNKSLVTTRLNL--SYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR
|.|..|.. |||| .  | ...||..|.| . .   ..... |. |...  .  . . ..|  . . |.| .... . .|||  || | . .|...||.|
mvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvr

AR----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|     . | |.||||||||.|| ..... |. |..  |. || |.|..|| . | | ||| .||. |....|..
alnepdagPivVhCSaGVGRTGtfividamlerikeektv.Diyqyvkalr.kqRnamVqteeQYiFiheailea

0040438 (Phosphotyrosine protein) phosphatases II 247-516 5e-79 261.1 In-house 7-277 (317) alignment
Range on Protein: 247-516
Range on HMM: 7-277/317.0
DFAMSSQKMTLDDFKQEFSNLPGDPPSdLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRM
.. .   |.    ...|| .|.  ...  .. .. |.| .|||| .|...| |||.|..... ...|||.|.|.  | ||| .|.||||...| .|||||
lalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

IWQENTTAIVMLCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA
.|....| ||||....| .|||||.|.|      |......| . . ..... . ..| ..  ...|.| .||. .. |||  || | . .|..|...|.
vweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

R----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFtLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGV
     ..| ..||||||||.||. |....|. .. .   .|....| .||   |. .|||..||. . ..||..  
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelre.qRpgavqtpeqyrflydalleylk

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 247-514 6.7e-45 148.5 In-house 14-283 (297) alignment
Range on Protein: 247-514
Range on HMM: 14-283/297.0
DFAMSSQK-MTLDDFKQEFSNLPGDPPSDLcTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSpfLKRGYILTQGPKKETRADFWR
|||   || .  | |..||  ||        |  .. || .|.|| ||   | |||.|... .. . ||. | ....   |  .| || |.|.| ||||.
dfatlvqknrhtdvfseeflclpeaniqpq.tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWa

MIWQENTTAIVMLCQFTETNReKCAEYFPRNAHCClqFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPG--SSEVMLKILRK
|...|....|||| .  |... ||| |.. ..     | ..||  .  .  .  .   |... .    .|..  . . |||| .|.   | . .||..  
mvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklise

IRA-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
.|       ..| ..||.||||| | |....  .  .. . .. || ..|..||   |   ||| .|| ......|..
vrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekev.difglvkklr.qerpylvqtkeqykfvyvavlea

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 248-527 5.4e-205 673.1 In-house 1-281 (281) alignment
Range on Protein: 248-527
Range on HMM: 1-281/281.0
FAMSSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKV-MPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRM
||||||||||||||||||||||||||||||.||||||||||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||
famssqkmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrm

IWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS
|||||||||||||||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
iwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars

TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLLDFGVAYKQITEELAE
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqiteelae

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 248-516 5.5e-49 161.4 In-house 14-290 (305) alignment
Range on Protein: 248-516
Range on HMM: 14-290/305.0
FAMSSQKMTLDDFKQEFSNLPGDPPSDLC-TAFN----QPVNNKKNRYLNIPCLDISRVQLKVMPnknSTDYIHANYIRSPFL-KRGYILTQGPKKETRA
| . .  . .| ...|| .|      |.  .|||      ..  |||| ..|| | | |.|.  .    .|||||||.  |.. .. .| .|||  .|  
fvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtid

DFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVsYEDSTV------NKSLVTTRLNLSYEGETR-LITHWLWKEWPDWQVPGSSEV
.|| |. |..   |||||.  |. . |||.|.|      |..    |  |. .       .  .  | |||.| |. .  . |  | ||||  ||     
efwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgiv.venvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklt

MLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
 |..|  ||    | |.|||||.||.||..|.|  |. |      | . ..|  ||   || |.|.  ||. | .|.|.. .
slellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalr.dqrafsiqndvqylfihrvmlnyfl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 249-517 1.1e-60 200.3 In-house 14-285 (319) alignment
Range on Protein: 249-517
Range on HMM: 14-285/319.0
AMSSQKMTLDDFKQEFSNLPGDPPSDLCTAfNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIW
 .  .. .   ...|| .| .  . .. .| ... |.||||| ||   | .||.|. .......||| |..| .   .. .| ||.|...|  |||||.|
lkalastgetllekefkllkeavndtfdsa.skeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

QENTTAIVMLCQFTETNREKCAEYFPRNahCCLQFDKMSVSYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-
.|..  .|||.. .|  . |. .|.|..  .  .. .. |  |.    . ..  .|.|     | ||| ..|. ..|||| .|| ..  .|..|..||  
eeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVA
     | | |.|||||||| || ......|. ..   .| |. ..||.|| | |   ||. .|| .|...||..  |
rektqsgPivvhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlR.tqRnimvqrpeqYkfiyealleavea

0050432 (Phosphotyrosine protein) phosphatases II 251-518 1.9e-81 269.1 In-house 35-302 (308) alignment
Range on Protein: 251-518
Range on HMM: 35-302/308.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpnKNSTDYIHANYIRSP--FLKRGYILTQGPKKETRADFWRMIW
  ... |  ...||  |.  .|.  ......| | .|||| .|...| ||| |     ....|||.|.|.. .   |.| .|.||||...| .|||||.|
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

QENTTAIVMLCQFTETNREKCAEYFPRNAH-CCLQFDKMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR
..|.. ||||....| .|||||.|.| . .  .|...|..| . . .|... ... | |..  .||.| .||. .. ||| .|| | | .|..|...| .
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

--STPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAY
  . | |.||||||||.||. |....|. .. .   .|. ..| .||   |. .|||..||... ..||..   .
lpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReq.Rpgmvqtpeqylflyralleylklk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 251-514 1.5e-60 199.7 In-house 14-278 (288) alignment
Range on Protein: 251-514
Range on HMM: 14-278/288.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
  .... ..|..|. .|.    ..  || ...||.||||| ||  .|  ||.|| .......||| |.|| .   |. || ||||  .|  |||......
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

NTTAIVMLCQFTETNREKCAEYFPRNAHcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----
.|. |||| .. | ...|| ||.| . .   .. .. |   .|   .. |. .| |  ... . ||.. .. ||| .|| |.. .|..||..   .    
ktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadt

TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
 | ..||||||||.|| .|.. ... .... .. |.  .|..||   ||  ||||.||. |..|||. 
gpiivhCsaGvGrtgtFialdalidaveeedyi.DvagtvaklRkq.RallvqtlkqYefiyevllsl

subfamily_Ptp69D_pd Subfamily Ptp69D 251-517 1.2e-54 180.5 In-house 15-288 (307) alignment
Range on Protein: 251-517
Range on HMM: 15-288/307.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
|... |   ...|. .|.    .  ... ..  |. |||| .|   |  ||.||... |...||| |..|..   |. .|  |.|  .|  ||||||.. 
srkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

NTTAIVMLCQFTETNREKCAEYFPRNahCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG-------ETRLITHWLWKEWPDWQVPGSSEVMLKILRKI-
. | |||| . ||.||.||| |.| .     |.... | . ..   .  .   |..|  .       ..| .. . ...|.| .|| ... .||..... 
evtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

---RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVA
   .   .| |.||||||||||...|... || ..   .. || ..| .||   |   || |.||. ... |||.   
elyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkv.difetvkdLrsq.RnllvqsleqYvflyralldyssy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 251-536 2.1e-52 173.1 In-house 9-301 (307) alignment
Range on Protein: 251-536
Range on HMM: 9-301/307.0
SSQKMTLDDFKQEFSNLPGDPPSDLCT-AFNqpVNNKKNRYLNIPCLDISRVQLKVmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQ
 . .. .. ...||..|    |  . . ||.   |..|||| ...| | .|. .|.  .  ..|||||||.      . .| .|||...|. .|| |. |
rtldkgvqalvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiq

ENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKM--SVSYEDSTV------NKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRK
|.  ...|||.  |. . || .|.| .    | | .   ..| ..  .      .. .  | |.. . ...| |.|. |..|||  ||      . .|  
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

IRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV-AYKQITEEL--AEKFNATYRRS
.|    | |.|||||||||||..|. .  . . .     |.|..|  ||   |  ..||  ||. . .|||.. .  ||.  |||  .....  | . 
vrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsq.rhyaiqteaqylylhrvlleyflelyketyeellltknyeekyakw

subfamily_PTPN6_pd Subfamily PTPN6 251-516 2.6e-52 172.7 In-house 19-298 (306) alignment
Range on Protein: 251-516
Range on HMM: 19-298/306.0
SSQKMTLDDFKQEFSNLPGDPPSDLCT--AFNQPVNNKKNRYLNIPCLDISRVQLKvMPNKNSTDYIHANYIR--SPFLKRGYILTQGPKKETRADFWRM
......  .|..|| .|  .  ..| .    ..| |..|||| ||   | .|| ||  |.   .||| ||||.  ..  .. || |||  ..| .|||||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLqFDKMSVSYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR
.||||.. |||. . .| ..|||| |.| . .    . |.||.  ... ... .  .|..|    ..|.| . .. .|.|||  || . ...|. |....
vwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

ARS--------TPPVIHCSAGVGRSGTLMAVEIALQSIHSHF--TLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
...         | |.|||||.|| ||.. ..| |. |...   .  ||...|  .| . |   ||| ||| ...|..  .  
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvr.eqrsglvqteqqykfvykaikkyie

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 251-514 3.7e-52 172.4 In-house 15-282 (305) alignment
Range on Protein: 251-514
Range on HMM: 15-282/305.0
SSQKMTLDDFKQEFSNLPGDppSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
...... ....... .|. .  .. .   .. .|..|||. .|  || .|..|.  .... .||| |.|. .   |  ||..||| |.| |||||.|..|
earvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrlivee

NTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST
 .. ||||..  | ...||  |.| .     .|...||  ....  . ... .|..|    . |.| ....   .|||  || ..  .|....... .  
kvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqk

-----PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
     | ..||||||||.|. .||.|||. ..   .. |. ... .|| . |   ||||.||. .. .| . 
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevv.dvfevlkqlRsk.rmkmvqtldqYvflhdaldel

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 252-513 8.8e-51 167.5 In-house 14-274 (515) alignment
Range on Protein: 252-513
Range on HMM: 14-274/515.0
SQKMTLddFKQEFSNLPGdPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQEN
... ||  | .|| .||| |     |  .. .| ||||| ||  .| .||.|.|. ..   ||. | ||.|    . || .|||.| .  ||||...|||
nrhttl..fseefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

TTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----T
.|.|.|. .  | .. ||..|.|      ..| ...|.          .  .|..  . ..| .| . ..||||  ||  .  .||......|       
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth

PPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
| .||||||||| | .....  .  ..      |. ..|  .|   |   ||| .|| .|. ..|.
pliihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirq.krpylvqtqeqyafiygavle

0036941 (Phosphotyrosine protein) phosphatases II 253-520 9.4e-79 260.1 In-house 8-282 (297) alignment
Range on Protein: 253-520
Range on HMM: 8-282/297.0
QKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENT
... |  ...||. |.   ..  ..... | | .|||| .|...| .||.|    .....|||.|.|.  . ||| .|.||||...| .|||||.|..|.
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

TAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTV--NKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----
| ||||....| .|||||.|.| .    |......| . . .|  ... ... | ...  .||.| .||. .. |||  || | . .|......|     
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--RSTPPVIHCSAGVGRSGTLMAVEIALQSIHS--HFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKQ
  ...| ..|||||||||||. |....|| ...  .   .||...| .||   |. .||||.||. .  .||..   ...
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq.Rpgavqtleqyrflyeallellkkklt

0047943 (Phosphotyrosine protein) phosphatases II 253-513 2.9e-76 251.9 In-house 7-270 (273) alignment
Range on Protein: 253-513
Range on HMM: 7-270/273.0
QKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENT
..  |. ...||  |.  .|.  ..... | | .|||| .|...| ||| |    . ...|||.|.|.. . ||| .|.||||...| .|||||.|..|.
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

TAIVMLCQFTETNREKCAEYFPRNAHC-CLQFDKMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-----
. ||||....| .||||| |.| .     |...|..| . . ..... ... | |..   ||.| .||.....||| .|| | | .|......|      
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 ...| |.||||||||.||. |....|. .. .   .|....| .||   |  .|||..||... ..||.
psngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsq.Rpgmvqtpeqyrflyealle

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 253-512 5.4e-37 122.1 In-house 10-290 (301) alignment
Range on Protein: 253-512
Range on HMM: 10-290/301.0
QKMTLDDFKQEFSNLPGDPpSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPN--KNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
 ..  ..|......|     .. ||   .  |.. ||. ||  .|  |. || .||  . ...|| |.|| .   |. .| .||| |.| .||||.||||
aakhsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

NTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTT-----------------RLNLSYEGETRLITHWLWKEWPDWQVPGSSE
 ...|||...  |. ..|| .|.|.  .   .| ...|   ...|  . |                   ... . . ... .. .   .||.  |     
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

VMLKI-----LRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFtLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLL
 .|..      |. .    | |.|||..|.|||. ..|.|.|    .     |. |..  .| . .   |.||.||. |..|. 
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrs.kpgaVtTLeqytsiydvid

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 253-516 2.1e-28 93.6 In-house 21-286 (302) alignment
Range on Protein: 253-516
Range on HMM: 21-286/302.0
QKMTLDDFKQEFSNLPGD-PPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKVMPNknstDYIHANYIRSPFLKRGYILTQGPKKETR---ADFWRMIW
....    |.|| ..     . . |.|| .  | |||.  ..|.||  .|.|.  |.    .|..|  .  | |.|  ||.| ||...    ..||||..
ksldtaevkkefkkidtmkvdlekCkafkk..nlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvf

QENTTAIVMLCQFTETNReKCAEYFPRNAHCCLQFDKMSVSYEDstVNKSLVTTrLNLSYE------GETRLITHWLWKEWPDWQVPGSSEVMLKILRKI
||. . .|.| .  | ..    |.||...   ....|| |      |.|.  ..  ....|       .. |..  . . |.. .|| .   . |   |.
qekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk..Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
       . . ||    |.|| |..... .|.......   | ||.||  .| . |...|..|.||. .. .|| .. 
fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiR.sqRpravdslkQyvslyialllyik

0051299 (Phosphotyrosine protein) phosphatases II 254-514 3.7e-79 261.5 In-house 19-285 (288) alignment
Range on Protein: 254-514
Range on HMM: 19-285/288.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
.  |  ...||  |.   |.  ..|.. | | .|||| .|...| |||.|.|... ...|||.|.||. . ||| .|.||||...| .|||||.|..|..
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

AIVMLCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS------YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR--
 ||||....| .||||| |.|   . .|......| . . .|... ... | ..      ..||.| .||. .. ||| .|| | | .|..||..|    
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

--STPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
  . | |.||||||||.||. |....|. .. .   .|. ..| .|| . |  .|||..||... ..||..
sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlr.eqRpgmvqtpeqyrfvyealley

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 254-513 4.8e-60 198.0 In-house 11-274 (281) alignment
Range on Protein: 254-513
Range on HMM: 11-274/281.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
.     |..|...|     ..  || ... | .|||| ||   | .||...   ....|||| ||.. .   ...|| ||||  .. ..||.|.|... .
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

AIVMLCQFTETNREKCAEYFPRNAHcCLQFDKMSVSYEDSTVNKSLVTTRLNL-SYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKI---RAR--ST
||||. .  |... ||  |.| ...  |.. .. |. . .. ... .. ...|   .|||| ...  .. |||  || ... .|.  ...   . .   .
aivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
| ||||||||||.|| .|.. ........ .  |.|..| .|| . |   |||. ||  ..|..||
plvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrke.rnlmvqtvvqyefvykavld

subfamily_PTPN13_pd Subfamily PTPN13 254-513 2e-50 166.6 In-house 7-267 (273) alignment
Range on Protein: 254-513
Range on HMM: 7-267/273.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnkNSTDYIHANYIRSPFLKR--GYILTQGPKKETRADFWRMIWQEN
|.  .. ..|| .|    | | |.  ..  |..|||| |.   | .||.|.     ... || |..|. |  |    ||..|||  || .|||.|.|. .
kldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

TTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDK-MSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---
.. |.|. .  |... ||  |.| ...  |.    . |. .. .  ...|  .|...    ||.| ..|  . .||| .|| |.. .|......|     
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd

STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
..| |.|||||.||||||......|. |.    . |.|.|| .||   | . ||| .||....|..|.
agPivvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreq.rqgvvqtkdqyifvykaile

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 254-516 1.5e-48 160.4 In-house 20-280 (315) alignment
Range on Protein: 254-516
Range on HMM: 20-280/315.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQpVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
  | . |||.. ..||     | .| .   | .|||| ||   | ||||| .. |.. .||. ||.|     || || .|||. ..  ||||....|. .
astkngfkqdyesipggqlhpldvakki.enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedig

AIVMLCQFTETNREKCAEYFPRNahcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPP
 |||| .  | ...|. .|.| .    . . |..|.  .  ||. .    |   .. . | .  . .  ||| .|| ..  .... |...       .. 
kivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgai

VIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
|.||||||||.||.....  |. ..    . |. ...  .|   |   ||...|| .|...||.  |
vvhcsaGvGrtGtfitldavldqaeae.naidvynfitgvrqn.rikmvqvaeqyqfiydalletfv

0043336 (Phosphotyrosine protein) phosphatases II 255-513 9.7e-76 250.2 In-house 17-275 (278) alignment
Range on Protein: 255-513
Range on HMM: 17-275/278.0
MTLDDFKQEFSNLPGDPPsDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
     ...|| .|.  .. | .. .. | | .|||| .|...| |||.|..... ...|||.|.|.  .  .|..|.|||| .|| .|||||.|....| 
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLCQFTETNREKCAEYFPrnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----RSTP
||||....| .|.|||.|.|      |......| . . ....  ... |...  ..||.| .||. .. ||| .|| | . .|..|...|     ...|
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

PVIHCSAGVGRSGTLMAVEIALQSIHSHFtLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 ..||||||||.||..|....|. ....   .|. ..|..||   |. .|||..||. . ..||.
vlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreq.Rpgavqtpsqyrflyealle

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 255-516 1.3e-44 147.4 In-house 16-272 (288) alignment
Range on Protein: 255-516
Range on HMM: 16-272/288.0
MTLDDFKQEFSNLPGDPPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
....  |.|. . | . . |  ..| .  |  ..|| |.|. ||.||.|.     ..  ||.|| . |   ||  | .| | . |   .|.|. ...   
iaveglkkeyrdspneasidiidsfia..nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdvey

IVMLCQFTETNREKCAEYFPRNAHCCLQFDKMS--VSYEDSTVNKSLVTTRLNLSYEGETRL-ITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPVI
|||||.. |  .|| ||||| .     .. ..   |  . . ..| .. . |. | |||..  . .  ..||.|  || .    |..|  ...   | |.
ivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivv

HCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
|.||||||.|||. . |||.|. ..  |  |......||   |  ..|| .||. .....|.  .
hssaGvGrtgtlililialeslrlddfl.girsllaklree.rfkaiqtemqylyvhrcvleell

subfamily_PTPN9_pd Subfamily PTPN9 257-520 6.8e-62 204.2 In-house 15-295 (297) alignment
Range on Protein: 257-520
Range on HMM: 15-295/297.0
LDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
    ..|. ..   |..   .|.....| .|||| .. |.| .||.|. ..... .|||.||..     |...| |||| |.|  |||||.|....  ||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---------
|  .. |. | ||..|.| . . . .| ..|||  .  ...  ... |...   ..|.| .||.    |||. || |.. .|..|.|.| .         
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

-------STPP-VIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVAYKQ
       | || |.|||||.||.||.....|.|. ...  |. |. . |..|| | || |.|| .||.. .. .|.. .  |.
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtv.dvvetvkllr.tqrafsiqtpeqyefcylavleyalelka

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 257-515 1.8e-46 154.0 In-house 33-294 (319) alignment
Range on Protein: 257-515
Range on HMM: 33-294/319.0
LDDFKQEFSNLPGDPPSDLCTA-FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAI
|  .. || ...  ...    .  | . |  |||. ||   | ..|.|. .  .. .||| | ..     |  || .|||...| ||||||||. |...|
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLCqftetnREKCAEYFPRNAHCclQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR------ARS
|.|       ..||..|.| ..    . ... |. .  .  .  |   ..||    | . | || . .. |||  || ..  ......|.|         
vllt......kdkcsqywplkivi..keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

TPPVIHCSAGVGRSGTLMAVEIALQSIHsHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD---FG
.. |.||||||||.|. ..... |. .. .    |. ..|  ||   |   || | ||..|.  ||.   ||
anivvhcsaGvGrtGvyivldvlldrmk.eekqvdvynfvrdlrq.qrntlvqdlvqykfiysalleehlfg

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 257-514 1.7e-42 140.7 In-house 22-287 (325) alignment
Range on Protein: 257-514
Range on HMM: 22-287/325.0
LDDFKQEFSNLPGDPPSDLcTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMI--WQentTA
 | | .||  || | .    ..  .| | .|||. |.  || ||| |. . .. |.||| |.|.|.   |  .. .| |. .|  |.||..  |.   ..
qdgfahefgllpsddgiak.kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...cs

IVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNL--SYEGETRLITHWLWKEWPDWQV---PGSSEVMLKIL----RKIRA-
.|..    ... ..|| |.|..     .|  . |.          |  .|..    .|||| .  . .. |.|  |   | .   .|...     ...| 
vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

--RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDF
   ||| ..||||||||.|.....  ||. .  .  . || . | .||   | . |.|  ||.||.. | ..
tkastpilvhcsaGvGrtGvfislysalakvieesrv.difgfvkklrk.drpsmvetvdqyiliyealvea

0045098 (Phosphotyrosine protein) phosphatases II 258-515 2e-66 219.6 In-house 7-272 (278) alignment
Range on Protein: 258-515
Range on HMM: 7-272/278.0
DDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQlkvmpnknstDYIHANYIRSPflKRGYILTQGPKKETRADFWRMIWQENTTAIVM
 |...|| .|.  .. . .| .. . | .|||| .|...| |||           |||.|.||...  .. .|.||||...| ||||||.|....|.|||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

LCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS------YEGETRLITHWLWKEWPDWQVPGSS--EVMLKILRKIRA-----
|....| .|||||.|.|   . .|......| ... .|..  ....|..       ...|.| .||. .. |||  || ..    .|..|. ||.     
ltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

------------RSTPPVIHCSAGVGRSGTLMAVEIALQSIhsHfTLPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLLDFG
            ...| ..||||||||.||| |. . |. .  .    |. ..|..||   .  .||.|.||. . ..||.. 
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_PTPRA_pd Subfamily PTPRA 258-515 3.6e-60 198.6 In-house 32-295 (330) alignment
Range on Protein: 258-515
Range on HMM: 32-295/330.0
DDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
  |..|| .||  |    . . ..  |..|||..||   | ||| | |.  ....||| | .|     |  .| .||||.||  |||||||. ....|||
klfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativm

LCQFTETNREKCAEYFPRNAhcCLQFDKMSVSYEDS------TVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----ST
| .. | ..|||| |.| .   .. . .. |. ||.      || | ||.   . . | ..||.. . .. |||  ||  .  |||.|.|...     . 
ltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
| |.||||||||.||.....  |. ...   . |. ..|..||   |.  |||..|| .|.||||.. 
pivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlq.rpqmvqtdeqyefiykvlleyy

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 258-513 3.4e-51 169.0 In-house 19-275 (315) alignment
Range on Protein: 258-513
Range on HMM: 19-275/315.0
DDFKQEFSNLPGDPPSDlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
  | .|| .||. ...   ..  ...| ||||| ||  || .||.|.|. ..   ||| | ||.|    . || .|||.| .  |||||..||..|.|||
alfseefhdlpdPdiyr.qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPPVIHC
. .  | .. ||. |.| .     .| ...|.  .   .   |. .| .    |.| .| . ..||||  |.  .  .||......|       . ..||
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

SAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
||||||.| .....  .. |.      |. ..|  ||   |   ||| ..| .|. ..|.
saGvGrtGvvisidevvaqikrt.rsvdvfnfvknlra.krpylvqteeeyafiydavle

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 258-513 2.3e-33 110.2 In-house 10-275 (287) alignment
Range on Protein: 258-513
Range on HMM: 10-275/287.0
DDFKQEFSNLPGDPpSDLCTAFN---QPVNNKKNRYLNIPCLDISRVQLKVMPNKnSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
|| ..|. .|  |        |    .  . ||||| ..  .| .|| |   ...  .||| |||. |   .  .| .|||   |  ||||.........
ddvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsas

IVMLCQFTETNREKCAEYFPRNaHCCLQFDKMSVSYEDSTVNKSL---VTTRLNLSYEGETRLITHWLWKEWPDWQVPGS----SEVMLKILRKIR----
.... .  |  | || .|.| . .  ..    ||   | .. .      . ||      |.|..    . .|||  .. .       .|.. ..|     
vitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard

-ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 .   |.|.|...|.||||.|.|. . ..   .     |. ..| .||   ||| ||.  |. |... |  
asevGPlvvhddvGiGrsGillatlvlvsrledl.Grvdvaavvirlrey.raalvqavvqlrllyealvt

0039614 (Phosphotyrosine protein) phosphatases II 259-514 5.1e-75 248.0 In-house 33-288 (297) alignment
Range on Protein: 259-514
Range on HMM: 33-288/297.0
DFKQEFSNLPGDPPSdlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNK-NSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIV
 ...|| .|.  .|.  .. .. |.| .|||| .|...| |||.||....  ...|||.|.|.  . | .| .|.|||| .|| .|||||.|....|.||
llllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

MLCQFTETNReKCAEYFPRNAHcclQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA------RSTPPV
||....| .| |||.|.| .     ......| . . ....  ... |.....||.| .||...  ||| .|| |.|..|..|...|       ...| .
mLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

IHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
.||||||||.||. |  ..|. ....   .|....|..||   |  .|||..||. . ..||..
VHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelr.eqRpgavqtpsqyrflydallel

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 259-526 6.5e-61 201.1 In-house 21-293 (318) alignment
Range on Protein: 259-526
Range on HMM: 21-293/318.0
DFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 ...|. .|  .. .   .  ..|||..|||| ||   | .||.|. . .....||| ||||     |. || .|.|  ||  |||||.|. |.. ||||
llseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

CQFTETNREKCAEYFPRNAhcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS-----TPPVI
 | .|  ..|.. |.| .     ...|. |  ....  ...|  ..... ..  |.| .  . . .|||  || |.  .|...|....       .| |.
tqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKQITE--ELA
|||||||| |. .||.| |. |.   .. |. |.|..||   | . ||| .|| .|..|||..  .... ..  .|.
hCsaGvGrtGvfiavdillerikaealv.Dvfqtvkqlreq.rnlmvqtedqyefiydvllealasgdtevdasdlr

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 259-514 3.2e-56 185.4 In-house 6-267 (274) alignment
Range on Protein: 259-514
Range on HMM: 6-267/274.0
DFKQEFSNLPGDPPSDlctAFNQPVNNKKNRYLNIPCLDISRVQLKV-MPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIV
|...|| .|| . . .     . . ...|||| .|   . ||| |.   .... ..|| ||||. .   .. |. ||||  .| |||||||.||... ||
dlekeflelPlnfdqe...eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLCQFTETNREKCAEYFPRNAHC--CLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-------RST
|| ...|.|..|||.||| . ..    .......  |. . ..    ..| |.|  ..| ..|... .||| ..| . . .|.......        . .
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakla

PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
| |.|||||.|| |  .|..||.. .. . .. |. .||..||.  |   ||| .|| ||...|  .
pvvvhCsaGiGrtGcfiaisiavrqlreeivv.dvlkivcnlrld.rGGmvqtseqyelihralcly

subfamily_PTPRK_pd Subfamily PTPRK 259-536 2.6e-52 172.6 In-house 23-296 (314) alignment
Range on Protein: 259-536
Range on HMM: 23-296/314.0
DFKQEFSNLPGDppsdlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 ||.|. .|.         | ..  |..|||. .|   | |||.|... . .|.||| |..| |    . .| ||||..|| .||||....||...||||
gfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivml

CQFTETNREKCAEYFPRNAHC--CLQFDKMSVSYEDSTVNKSLVTTRLNLSYEgETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST----PPVIH
 ...|. | || .|.| ...    ..   .... .   |.. .  ..|. ..| |.|.. .. .  |||..|| | . .||..|.. . .     . |.|
telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqe.eirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKqiTEELAEKFNATYRRS
|||| ||.|| .|..| |. |. . .. |. ..|  || . .   |.| .||..|. |.|.  .. .  |   . .|.|.|  |
CsaGaGrtGtfiaidivldmieregvv.dvfnavktlrsr.kvnmveteeqykfiydvileaclcge..taipvsefkalyles

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 259-529 3.7e-51 168.7 In-house 23-301 (305) alignment
Range on Protein: 259-529
Range on HMM: 23-301/305.0
DFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 ...||...      .   || .  ...|||| .. |||  ||.|.   .    .||||||. .|   . .| || | ..| |||| | .|..  || ||
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkle...gpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

CQFTETNREKCAEYFPRNAHCCLQFD----KMSVSYEDSTVNKS-------LVTTRLNLSYEG-ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS
|.. |   .||.|||. . .  |.|.    |.|| .| |.  |        .  | | .   | ..| .||. | .|||  || .   .|..| | |.  
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk

TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQITEELAEKF
 | |.|||||.||.|... .|  |. . .   . | ..|. ..|   |  |.|| .||... .|.|..    | . ||  | .
gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkire.qrnnsiqtdaqylfvhqvilnyfrkkklldeevkeay

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 259-513 3.7e-40 132.5 In-house 21-234 (392) alignment
Range on Protein: 259-513
Range on HMM: 21-234/392.0
DFKQEFSNLPGdPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 | .|| .||| |.    |. ....| ||||| ||  .| .||.|.|. . . .||. | ||.|   .. || .|||.  .  |||||..|||.|.|.|.
lffeefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

CQFTETNrekcaeyfprnahcclqfdkmsvsyedstvnkslvttrlnlsYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----STPPVIHCS
 .. | .                                             ..| .. . . |||| .||  .  .||......|     . | .||||
tklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcs

AGVGRSGTLMAVEIALQSIHsHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
|||||.| .....  .   . .  . |. ..|. .|   |   ||| .|| .|.  .|.
agvgrtgvvisidsvvahak.ktrmvdvfnfvtnirr.krpymvqtkeqyafiygavle

0046845 (Phosphotyrosine protein) phosphatases II 260-518 3.7e-77 254.8 In-house 2-277 (284) alignment
Range on Protein: 260-518
Range on HMM: 2-277/284.0
FKQEFSNLPGDPPSD--LCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNK-NSTDYIHANYIRSP-----FLKRGYILTQGPKKETRADFWRMIWQEN
...||  |.   ..    ..... | | .|||| .|...| ||| ||..... ...|||.|.|.. .       |. .|.||||...| .|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TTAIVMLCQFTETNREKCAEYFPRNaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---
.. ||||....| .||||| |.| . . .|......| . . .|... ....| |..   .||.| .||. ...||| .|| |.| .|..||..|     
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

---STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFT--LPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAY
   . | |.||||||||.||. |....|. .. . .   .|. ..|..||   |  .||||.||... ..||..   .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre.qRpgmvqtleqyrfvyealleylklk

DSPc_SM00195 260-514 3.9e-76 251.2 In-house 2-261 (263) alignment
Range on Protein: 260-514
Range on HMM: 2-261/263.0
FKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
.|.||..|    ... .|  ... |..|||| ||.. | .||.||  ..|...|||.||||. .  |. ||.||||...| .|||||.|.|... ||||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNK-SLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----STPPVIH
.. | ..|||..|.|....   .|.|.||   . .  | ..... |.|..||  ||| .|.. .|.||| .|| | . .|..||... .    |.| |.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTLMAVEIALQSIHSHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||||||.||.....|.|........ .||..||..|| . |. .||||.||. | ...|..
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelR.kqRpgmvqtleqYlfiyeailey

PTPc_SM00194 260-514 3.9e-76 251.2 In-house 2-261 (263) alignment
Range on Protein: 260-514
Range on HMM: 2-261/263.0
FKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
.|.||..|    ... .|  ... |..|||| ||.. | .||.||  ..|...|||.||||. .  |. ||.||||...| .|||||.|.|... ||||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNK-SLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----STPPVIH
.. | ..|||..|.|....   .|.|.||   . .  | ..... |.|..||  ||| .|.. .|.||| .|| | . .|..||... .    |.| |.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTLMAVEIALQSIHSHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||||||.||.....|.|........ .||..||..|| . |. .||||.||. | ...|..
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelR.kqRpgmvqtleqYlfiyeailey

0045450 (Phosphotyrosine protein) phosphatases II 260-514 2.3e-73 243.0 In-house 29-303 (307) alignment
Range on Protein: 260-514
Range on HMM: 29-303/307.0
FKQEFSNLPGDPP--SDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNK-NSTDYIHANYI--------RSPFLKRGYILTQGPKKETRADFWRMIW
...||  |.   .  .. ..... |.| .|||| .|...| .||.|...... ...|||.|.|.         .. ||| .|.||||..|| .|||||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

QENTTAIVMLCQFTETNREKCAEYFPRNaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-
....|.||||....| .|||||.|.| .    |..... | . . .. .... ..|...   ..||.| .||. ...||| .|| | | .|......|. 
eqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTL--PDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
     ...| ..||||||||.||..|  ..|. .... ||  .|. ..|..||   |  .||...||. . ..||..
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllr.eqRpgavqnpeqyrflyeallel

subfamily_PTPRG_pd Subfamily PTPRG 260-514 6e-51 168.3 In-house 21-286 (563) alignment
Range on Protein: 260-514
Range on HMM: 21-286/563.0
FKQEFSNLPGDPPSD--LCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNST-DYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
|..|| .|     |.   ... ..| | .|||||||   | |||.|. .|.|... ||| ||||     .. .| |||| |.|  |||||||..|.. ||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY-----E---GETRLITHWLWKEWPDWQVPGSSEVMLKILRKI-RARST
|. ...| .|.||  |.|.     .......|  ... |  .  . .| .       .    . .|.... . .||| .|| .|   |.  .|  .|. .
mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

---PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
   | |.||||||||.||.....  |. |... .  .. ... |.|   |   |||  ||. ....||. 
eaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraq.RnflvqteEqYiflhdallea

subfamily_PTPN14_pd Subfamily PTPN14 260-514 3.7e-46 152.5 In-house 25-295 (300) alignment
Range on Protein: 260-514
Range on HMM: 25-295/300.0
FKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMpNKNSTDYIHANYIRSPF--LKRGYILTQGPKKETRADFWRMIWQENTTAIVM
  .|. ..|      |... . |.|..|||. ..   . .||.|.   ..|||.|| |  |. .    .| || .||| . |  |||.|.|..... |||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelspt.kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LCQFTETNREKCAEYFPRN--AHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA---R-----
| . .|  .||. .|||..   .  ..|.|  |. . |.  .|..|| |.| .   .| | . |  ...||| .||   . .|. |.....   .     
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

-----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
     . | ..||||||||.| |. ... .....   .. |||.....|| . |   |||| ||  ..|||. .
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneei.dikkvlarLr.eqrmllvqtlaqYkfvYkvliky

subfamily_CG7180_pd Subfamily CG7180 260-517 4.6e-36 119.0 In-house 19-292 (296) alignment
Range on Protein: 260-517
Range on HMM: 19-292/296.0
FKQEFSNLPGdPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
.|.|.   |    .. | .  .  | .|||. ..   |  || |. .  ....||| | |. |   |. || |..|||||  .|||....|.. |.|.|.
yklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

QFTETNReKCAEYFPRNAhcCLQFDKMSVSYEDST-----------VNKS-LVTTRLNLSYEGETRLITHWLWKEWPD-WQVPGSSEVMLKILRKIRA--
. .. .. .. .|.| ..    |. .. | .  .            ..|  . .|  .   . |||....  ..||.   .|| |.. .....|..|   
ktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

-R------STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVA
 .        | |...| |..|||  .|....|. .. .  . |. . |  ||   |   |.. ..|. |. |||.. ..
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeev.dvFeavktlrr.sRpqLvenveeYkyiYdvlleavlc

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-534 2.4e-35 116.7 In-house 21-297 (312) alignment
Range on Protein: 260-534
Range on HMM: 21-297/312.0
FKQEFSNLPGDPPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKVmpNKNstDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
. .|.  .    .   |||| .   .  ||| || | |  |  |    ..|   |||||...       .. |||| ..| . ||..     .|.|..||
ltkeykavgnivsdsectaflk..fkdlnrypniqcwdrgrftlag..den..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QFTETNREKCAEYFPRnAHCCLQFDKMSVSYEDST------VNKSLVTTRL---NLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPV
 | |   ||||.|        ....   |  |  |        |  .| |.    .   |.   . |. |  |||  .| | .  |..|  ..    | .
gfvedgsekcakyisd.ivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpvi

IHCSAGVGRSGTLMAVEIALQSIhSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVA---YKQiTEELAEKFNATYR
 ||||||||.|||. .|  . ..  |    ..|..   ||   || ||... ||.   ...|.|  .   ||.  |.   ||. || 
ahcsagvgrtgtlaliesmiaal.rhprkqnvkdsfvllr.kdrarsvrvfpqyvyalrcvleflyskglykr.neqewtkfketya

subfamily_CG42327_pd Subfamily CG42327 260-444 8.9e-26 85.3 In-house 7-192 (319) alignment
Range on Protein: 260-444
Range on HMM: 7-192/319.0
FKQEFSNLPgdppSDLCTAFNQPVN-NKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIVM
  .|| .||      .  | . ||  ..|.|..|.  |  .|| |. ....... |..|.|.| .   .  || .| . ... .||||..|. ..  || 
vaeefrdlP....qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

LCQFTETNREKCAEYFPRNAHC--CLQFDKMSVSYEDSTVNKSLVTTRLNLS-Y-EGETRLITHWLWkEWPDWQVPGSSEVMLKILRKIRA
|..  |   ..||||.| ..       . .. |.  .  |..  ... | |    . |.| .||. . .|.. .|| . . .. .| ..|.
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

subfamily_PTPN3_pd Subfamily PTPN3 263-510 2.1e-50 166.2 In-house 20-270 (280) alignment
Range on Protein: 263-510
Range on HMM: 20-270/280.0
EFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIR----SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
.| .|    |.  ..| ..| | .|||| .|   |. ||.||    ...|||| |||.     |  |   || |||| ..| .|||.|.|..... ||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

CQFTETNREKCAEYFPRNAHcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----RSTPPVIH
 . .|  | || .|.|.. .  |.. ..||  | .  .|| |.  | |. .   | | |..  . .||| .|| .|. .|......|.    ...| |.|
ttlverGrvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKV
||||.||.| |...|.||. | ..  .  . .||...|   ||. ||| .|| .. . 
CsaGigrtGvlilletalalieaaepv.ypldivrtmr.dqramlvqtasqykfvCea

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 270-360 2.9e-08 27.6 In-house 24-118 (347) alignment
Range on Protein: 270-360
Range on HMM: 24-118/347.0
DPPSDlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVM-----PNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQ
  ||. .|. .   . .|||  .    | .|| |        .  ..  || | .|.    .. ||||| |  .|  |||.|.   . | .| . .
yspsk.ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

0049772 (Phosphotyrosine protein) phosphatases II 271-515 4.7e-43 143.5 In-house 33-280 (314) alignment
Range on Protein: 271-515
Range on HMM: 33-280/314.0
PPSDLCTAFNQPVNNKKNRYLNIPCLDiSRVQLKVMPNKNsTDYIHANYIRSPflkRGYILTQGPKKETRADF----------WRMI--WQENTTAIVM-
.|.  ........| .|||||.|.. | .||.|. .|... .|||.|.|....   . .| ||||...|  ||          |||.  .. |.  ||| 
lpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LCQFTETNREKCAEYFPRNAhcclqfdkmSVSYEDSTVnkslvttrlnlsyegeTRLITHWLWKEWPDWQVPgSSEVMLK
                    |..... . | .|....            .. |... .                .||. ..|.  .||...| ..| ...
rdevladelsrLdaAlgKtpllildgngneptaadlellk.........eelydpelf................erlgikylripvpDgsap.lledfde

ILRKIRA--RSTPPVIHCSAGVGRSGTLMAVEIALQSIhsHFTLPDIKQIVSHLRV-TGRAASVQTLQQYMLIWKVLLDFG
.|. |..  . .| ..||.||.||.||.... . .     ...| .. . |   |    .  ....|.||  |...||.. 
flefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

subfamily_egg_pd Subfamily egg 275-515 1.7e-44 146.7 In-house 32-270 (307) alignment
Range on Protein: 275-515
Range on HMM: 32-270/307.0
LCTAFNQpVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETnrEKCAEYFP
| ||...  | .| |   ..| | |||.|..   . . |.||||...   |   .||.| | |.|  |||||..||.   ||||    |.  |.|  |.|
lttaasd.nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

RNAHCCLQFDKMSVSYEDSTVNK----SLVTTRLNL-SYEGETRLITHWLWkewpDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIA
.     |..   |.  |   |..     .  |.|.|   . | | . || .    |..  .     |..|||.|  |.| |...  || ...||.|.|||
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieia

LQSI-HSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
| |.     |   ... |  ||   |  ||..  .|.......| | 
llsllrGpitkslvlravvflrlr.rrlsvesvllylfvyrlvlfff

0040439 (Phosphotyrosine protein) phosphatases II 276-514 2.1e-68 225.9 In-house 3-245 (249) alignment
Range on Protein: 276-514
Range on HMM: 3-245/249.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPR
.. .. |.| .|||| .|...| |||.|...|. . .|||.|.||  .  || .|.|||| .|| .|||||.|... |.||||....| .|||||.|.| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

naHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA------RSTPPVIHCSAGVGRSGTLMAVE
     |......| . . .|....... | |.  |.||.| ..|. .  ||| .|| | | .|......|       ...| ..||||||||.||. |  
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

IALQSIHSHFTlPDIKQIVSHLRVTGrAASVQTLQQYMLIWKVLLDF
..|. .. . .  |....|..||      .||...||. . ..||..
lmleqlekelg.vdleeavkllrsqR.pgavqnpeqyrflyeallel

0042113 (Phosphotyrosine protein) phosphatases II 276-513 5.9e-68 224.2 In-house 1-241 (245) alignment
Range on Protein: 276-513
Range on HMM: 1-241/245.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPR
.. .. |.| .|||| .|...| .||.|..... . .|||.|.|.  .  ....|.|||| .|| .|||||.|... |.||||....| .|.|||.|.| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

naHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEI
  .. |......| . . ......... |...  ...|.| ..|...  ||| .|| ..| .|..|. .|      ...| ..||||||||.||..|. .
..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
.|. ....    .. ..| .||   |  .|||..||. . ..||.
mleqleke.lgvsleeavkelrsq.Rpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 276-512 1.5e-60 200.1 In-house 2-239 (243) alignment
Range on Protein: 276-512
Range on HMM: 2-239/243.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpnkNSTDYIHANYIRSPflkRGYILTQGPKKETRAD----FWRMIWQENTTAIVMLCQFTETNREKCAE
.. .. |.| .|||| .|...| ||| |      ...|||.||.|. .   ...|.|||| .|| .|    ||||.|....|.||||....| .|||||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YFPrNAHcclQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR------------ARSTPPVIHCSAG
|.| . .   ......| . .... .. . . | |..   ...|||..|...  ||| .|| | | .|..|...|             .. | ..|||||
ywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRSGTLMAVEIALQSIhsHftlPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLL
|||.||| |  . |. .  .    |. ..| .||      .|||..||. . ..||
vgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 276-516 3.5e-35 116.4 In-house 27-271 (285) alignment
Range on Protein: 276-516
Range on HMM: 27-271/285.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLK-RGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFP
||      |   ||| .. |.. .|| ||    .   |||||...| |      || ||||  || .|||.||.||. . ..||| . |   |||| |.|
ctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

RNAHCCLQFDKMSVSYEDS-------TVNKSLVTTRLNlSYEGETRLITHWLWKEWPDWQVPGSSEVML---KILRKIRARSTPPVIHCSAGVGRSGTLM
 .    ..| |  ..  .        |. ..|  .  .     |   . |     |||   |  .  |.   | ..|.  . .| ..||||||||. |..
eklgevvkfgkyeitlteckeeaiagtilnaltvinte.dasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfv

AVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
 .. |   |     . .. .||  .|   |  .||.  |..... ||... .
gidyatirimenpni.emldivremram.rfqavqshmqflflyvvlmeyfi

subfamily_PTPN1_pd Subfamily PTPN1 277-508 7.8e-51 167.5 In-house 25-264 (290) alignment
Range on Protein: 277-508
Range on HMM: 25-264/290.0
TAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRN
.. ..| |...||| ..   | ||..|.    ....||| |. .  . .|| |||||||  .| . ||.|.|.... |.||| .. | .. |||.|.|..
reaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

AH-CCLQFD--KMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMA
 .  .|...  |..| .    ...  .   |.|      ||| |.|. .  |||. || |   .|| | |.|          |.|||||||.|||||.. 
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

VEIALQSIHSHFT--LPDIKQIVSHLRVTgRAASVQTLQQYMLIW
|.  |  |. .      |||. . .||   |   .|| .|  . .
vdtclvliekkddlssvdikkvllelrky.rlGliqtadqlrfsy

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 278-515 1.4e-45 151.0 In-house 19-258 (284) alignment
Range on Protein: 278-515
Range on HMM: 19-258/284.0
AFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCqftetnREKCAEYFPRNA
  | . |  |||. .|   | ..|.|. .  .. .||| | .|     |  || ||||...| ||||||||. |...||.|       ..||..|.| ..
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

HCclQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR------ARSTPPVIHCSAGVGRSGTLMAVEI
    . ... |. .  .  .  |   ..||    | . | |. . .. |||  || ..  ......|.|         .. |.||||||||.|. .....
vi..keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

ALQSIHsHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD---FG
 |. .. .    |. ..|  ||   |   || | ||..|.  ||.   ||
lldrmk.eekqvdvynfvrdlrq.qrntlvqdlvqykfiysalleehlfg

subfamily_PTPRN_pd Subfamily PTPRN 278-509 3.4e-38 126.0 In-house 50-286 (297) alignment
Range on Protein: 278-509
Range on HMM: 50-286/297.0
AFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPF-LKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRN
. ... | ||||. ..   | |||.||   .....||| |  |      .  || ||||  .| ||||.|.|.. .. ||.|.. .|.. ..|..|.| .
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

AHCCLQFDKMSVSYEDSTVNKSLVTTR-LNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKI----RARSTPPVIHCSAGVGRSGTLMAVEIALQ
 .   .. .. .  |    .  || .  |      ||| .| . .  ||. .|| |.  .|.  ||.    | ||.| |.|||.|.||.|. ..... |.
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln

SIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWK
 .       ||   . |||   |.  |.| .|. ....
rllkGvkeidiaatlehlr.dqrpglvktkdqfefalt

subfamily_PTPN12_pd Subfamily PTPN12 279-516 8.8e-60 197.0 In-house 35-278 (290) alignment
Range on Protein: 279-516
Range on HMM: 35-278/290.0
FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAH
 ....| ||||| .|   | |||.|. . ...  ||| ||.|. .  |  || .|||  .|  |||||||. |.. .||.|.  | .. ||. |.| . .
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

CCLQFDKMSVSYED-STVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----RSTPPVIHCSAGVGRSGTLMAVEIALQSI
  |.|....|. |.  .|.. ..   |..  ..|.| .. . ...||| .|| | . .|......|      ..| |.|||||||| ||..|.... . .
eelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrell

HSHFT--LPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
... .    |. ..| .|| . ||| ||| .|| |..| ....  
kaekipeeldvfdlvlelr.kqraalvqtkeqyelvykavaelvq

subfamily_ptpA1_pd Subfamily ptpA1 279-481 6.9e-36 118.9 In-house 42-264 (418) alignment
Range on Protein: 279-481
Range on HMM: 42-264/418.0
FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRgYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAH
 ..  |  |||| ||  .. .||||| . .|. .||| ||||   . |. .| ||||  .| ||||||.|..    |||| . .|  | ||  |.| .  
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

C---------CLQFDKMSVSYEDS--TVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----------STPPVIHCSAGV
             |   ||   .     .. ..|  . |..||||| ||.. .. ||| ..|  .. . ..|. |  |            | ..||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRSGTLMAVEIALQSIHSHFTLPD
||.||. .  | .. .  .|   |
grtgtfctavimmkkldhyfkqld

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 280-512 2.8e-37 123.2 In-house 4-238 (239) alignment
Range on Protein: 280-512
Range on HMM: 4-238/239.0
NQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAH
.. ||. |||| ||   | ||| |. . |   .||| |.|.|      . || |||  . .  |||||.|||    ||||  . |  ..|| .|.| .. 
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

cclQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST----PPVIHCSAGVGRSGTLMAVEIALQS
   .. .. |.   . |    .   . .|  |  | | . .. .  |||  ||  .  .| . |||   |     | ||||||||||.|... ..  |. 
...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLL
 . . |. || . |  .|   |   ||| .||..|   .|
akkqktv.difnyvkaire.drphmvqtseqyvfihlavl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 281-517 3.5e-49 162.3 In-house 6-244 (250) alignment
Range on Protein: 281-517
Range on HMM: 6-244/250.0
QPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREkCAEYFPRNAhcC
.| |..|||| .|  || ||| |.     . .||| | .. .   .. .| |||| ..|  |||||...|....|||| ...|.... . .|.| .    
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..a

LQFDKMSVSYEDSTVNKSLVTTRLNLSYEGET--RLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR-----STPPVIHCSAGVGRSGTLMAVEIALQSI
 .. .. ||  .. .   .....| || . ..  |.. .  .  |||  ||   . .|..|.|..|      ..| ...|||||||||. .|..  |. .
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

HSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVA
.   .. |. ...  ||   |  .|..|.||. .....| . ..
kkekvv.dvfkvikvlrk.drphavesleqyvfvyeiilkalds

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 281-512 2.9e-37 123.1 In-house 4-237 (239) alignment
Range on Protein: 281-512
Range on HMM: 4-237/239.0
QPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHc
. ||. |||| ||   | ||| |. . |   .||| |.|.|      . || |||  . .  |||||.|||    ||||  . |  ..|| .|.| ..  
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

clQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST----PPVIHCSAGVGRSGTLMAVEIALQSI
  .. .. |.   . |    .   . .|  |  | | . .. .  |||  ||  .  .| . |||   |     | ||||||||||.|... ..  |.  
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

HSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLL
. . |. || . |  .|   |   ||| .||..|   .|
kkqktv.difnyvkaire.drphmvqtseqyvfihlavl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 282-513 8e-47 154.5 In-house 31-264 (283) alignment
Range on Protein: 282-513
Range on HMM: 31-264/283.0
PVNNKKNRYLNIPCLDISRVQLKVMPNknstDYIHANYIR---SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAh
  |..|||. .|   |  ||.||  ..    ||| | .|    |   ...|| .|.| ..|. |||.|...|. |||||| .. | .|.||. |.|..  
denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.

cCLQFDKMSVSYEDSTVNKSLVTTRLNLSYE---GETRLITHWLWKEWPDWQVPGSSEVMLK---IL-RKIRARSTPPVIHCSAGVGRSGTLMAVEIALQ
   .. .. |. .. | ..|..   | | ..    .| |..|.   .| ...     . ..|   .   . . . .| |.|||.|.||.....|.  ...
.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

SIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 . .. .. |. ..|  .|.  |   ||||.||.|. .. |.
dalte.svvdvfavvkimreq.rmmavqtldqyklvhelvle

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 282-433 6.6e-29 95.7 In-house 31-184 (297) alignment
Range on Protein: 282-433
Range on HMM: 31-184/297.0
PVNNKKNRYLNIPCLDISRVQLKVMPNknSTDYIHANYIRSPFLKR--GYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHC
.   .|||| .|   | .||.|.  .    .||| |.|.  |  .    |||.||| ..|  |||.......  .|||.... |  |.||| |.|.    
nsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

CLQFDKMSVSYEDST---VNKSLVtTRLNLSYEGETRLITHWLWKEWPDWQVPGSSE
 |.  .. | .  ||    ..  . | |.| |  |.| ..|  .  |||  ||   |
rlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdle

subfamily_PTPN23_pd Subfamily PTPN23 283-512 1.7e-46 153.3 In-house 42-277 (288) alignment
Range on Protein: 283-512
Range on HMM: 42-277/288.0
VNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCL
.. .|||. .|   | .||.|.    ..  ||| | ....       .| ||.|...| .|||.|.... .  |||| . .|....|...|.| .     
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

QFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA--------RSTPPVIHCSAGVGRSGTLMAVEIALQ
.|...||. .. .  .  |   |.|. ..  ... ..|  ...||.  || | |..|..| ....          || |.||||||||.|..  |  |..
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

SIHSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLL
 .. .  |.|| |.||.||   |  .||. .|.   ... |
elekgnglldiiqvvsrlreq.Rrfmvqekeqlkfsyeavl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 283-523 1.1e-37 124.4 In-house 49-284 (301) alignment
Range on Protein: 283-523
Range on HMM: 49-284/301.0
VNNKKNRYLNIPCLDISRVqlKVMPNKNSTdYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQ
....|.|| ..||   . |  .|. . .    ||||.| ..   . .| |||| |.|. ||| |. | .   ||||.|. | . |||.||.| . .  |.
lpkdkhryptvPckPstav..evivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

FDKMSVSY--EDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHF
 .. ..    ... .||...  .|..     . .|| .||. ..||.| .|| |   . ...  ..    | |.|||||.||| .... |.  . .... 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadp

TLpDIKQIVSHLRvTGRAASVQTLQQymLIWkvlLDFGVAYKQITE
|. .... . |||   |  .||| .|  | |   . .|  |. | |
ti.eltealkhlr.ehrwngvqtnsq..lyw...mtlGtvyrlike

Y_phosphatase Protein-tyrosine phosphatase 284-512 3.6e-72 237.9 Pfam-A 1-234 (235) alignment
Range on Protein: 284-512
Range on HMM: 1-234/235.0
NNKKNRYLNIPCLDISRVQLkvMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQF
| ||||| .|.. | .||.|    .....|||.|||...   |. .|.|||| |.| .|||||.|||....||||.. .| .|||||.|.|.. .  |..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKMSVSYE-DST-VNKSLVTTRLNLSYEGET---RLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPPVIHCSAGVGRSGTLMAVEIALQSIH
....| .. ...  .|. ... |.|. ..|    | .... ...|||..|| |.. .|...||.. ..    .| |.||||||||.||..|..|.|....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

SHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
.. . .|..|||..|| . |. .||.|.||. . |..|
aeee.vdvlqivkelR.kqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 284-512 3.6e-72 237.9 In-house 1-234 (235) alignment
Range on Protein: 284-512
Range on HMM: 1-234/235.0
NNKKNRYLNIPCLDISRVQLkvMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQF
| ||||| .|.. | .||.|    .....|||.|||...   |. .|.|||| |.| .|||||.|||....||||.. .| .|||||.|.|.. .  |..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKMSVSYE-DST-VNKSLVTTRLNLSYEGET---RLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPPVIHCSAGVGRSGTLMAVEIALQSIH
....| .. ...  .|. ... |.|. ..|    | .... ...|||..|| |.. .|...||.. ..    .| |.||||||||.||..|..|.|....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

SHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
.. . .|..|||..|| . |. .||.|.||. . |..|
aeee.vdvlqivkelR.kqRpgmvqsleqYiflykail

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 284-514 9.5e-55 180.5 In-house 20-263 (270) alignment
Range on Protein: 284-514
Range on HMM: 20-263/270.0
NNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIR-SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCC--
..| ||| .|     .||.|. . ... | || |||.|     |. || ..||.. |  .||||||.|..|||||. ...| .|.||. |.| ...    
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

LQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSE------VMLKILRKIR------ARSTPPVIHCSAGVGRSGTLMAVEI
|.. |..|  . .. ..  ..|||.| ..||.| ..|. ...|||  || ...       .||.||..|      ....| ..||||||||.|||.|..|
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

ALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|.. ....  . |. .|...||   | | ||. .|| ...|... .
avrlLeetkkv.dvlaiieelR.kdRmalvqhpeqyeflykavvey

0041856 (Phosphotyrosine protein) phosphatases II 284-513 1.4e-42 140.7 In-house 1-169 (182) alignment
Range on Protein: 284-513
Range on HMM: 1-169/182.0
NNKKNRYLNIPCLDISRvqlkvmpnknSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCqftetnrekCAEYFPrnahcclqf
| .|||| .|.. | ||            |||.||......  . .|.|||| ..| |||.||..... |.||.|.         .  |.|         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dkmsvsyedstvnkslvttrlnlsyEGETRLITHWLWKEWPDWQVPGsSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSihsHFTLPDIK
                         | ..||....|.  |||. ||   . .|.......... | ..||||||||.||| |  . ..    ...|... 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...gvsleeav

QIVSHLRvtgrAASVQTLQQYMLIWKVLLD
. |   |      .|.|..|| ..  .||.
klvrsrR....pgmvitpnqyfflqlalle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 284-512 5.7e-37 122.2 In-house 3-236 (237) alignment
Range on Protein: 284-512
Range on HMM: 3-236/237.0
NNKKNRYLNIPCLDISRVQLKVMPNKnsTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHcCLQ
|. |||| || . | ||| ||   ..  .||| |.|...     . || .||| . .  |||.|.|||. . ||||  . | |..|| .|.|        
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paa

FDKMSVS------YEDSTVNKSLVTTRLNLSyegETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMAVEIAL
. ...||      . | ||   |...||.|    | |||  . .  |||  ||  .  .|.. ..|  |      |.| .|||||||||.| .. ..  |
ygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

QSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
.  . .  . || . |  .    |   .|| .||..| ...|
rqakek.kvvdiynyvysie.edrpyiiqtkdqyvfihqtil

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 284-517 9.1e-25 82.1 In-house 33-259 (267) alignment
Range on Protein: 284-517
Range on HMM: 33-259/267.0
NNKKNRYLNIPCLDISRVQLKVMPNKnstdYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNrekCAEYFPRNAHCCLQF
|...||. .    | .|| |.   .     || | |. .   |. .|.||.| | | .||. .| ... . ||.| .  . |      ..| .   . ..
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakky

DKMSV--SYEDSTVNKSLVTTRLNLSYEGeTRLITHWLWKEWpdwQVPGSSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMAVEIALQSIHS
. ..|  | |    .  ..|  |..  |  .. .| . .|.|   ..    .  || |  | |.      . | |..||.|||||||.. ..  |. .  
qdltvehslekeendyqiitlelkfknes.ahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt

HFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFgvA
  .. || . . ..|   | . |.|...|. | ..| ..  |
egvs.difdflrkirs.qriglvdtkeryiyihellaey..a

subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 284-385 2e-07 22.7 In-house 29-118 (275) alignment
Range on Protein: 284-385
Range on HMM: 29-118/275.0
NNKKNRYLNIPCLDisrvqlKVMPNKNSTDYIHANYIRSPFlkRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETnrekCAEYFPRNAHCCLQF
| .|||. |. |.|      ...  .|   ..||| .|.|.    ....| |.  | ||. ...|  |  ..| |    |.       . |..      |
ngeknrftnvtcfd......eildrenqeffvhantfrtpy..gnflisqapndstnadhlhllwiynvqtvvclvlpeea....ggyfvpkegetftsf

DK
.|
qk

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 284-369 1.6e-06 21.9 In-house 33-118 (332) alignment
Range on Protein: 284-369
Range on HMM: 33-118/332.0
NN-KKNRYLNIPCLDISRVQLkvMPNKNSTDYIHANYIRSPFLKRGYILTQGPKK-ETRADFWRMIWQENTTAIVMLCQFTETNREKC
||   ||   . |.| |||.|   |.    |.  |...     |  ||..| | .  |   ||||. . . . |... .  | .. |.
nnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 286-377 6.6e-17 56.2 In-house 49-154 (350) alignment
Range on Protein: 286-377
Range on HMM: 49-154/350.0
KKNRYLNIPCLDISRVQLKV--------MPNKNSTDYIHANYIRSP----FLKRG--YILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAE
 |||| ||   . |||.||             .. ||| |||.. .      . .  || ||.| ..|  ||...| . . . |..| .  | |.||| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YFPRNA
|... .
YWqegs

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 287-533 1.8e-40 133.9 In-house 21-279 (290) alignment
Range on Protein: 287-533
Range on HMM: 21-279/290.0
KNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRgYILTQGPKKET-------RADFWRMIWQENTTAIVMLCQFTETNRE----KCAEYFPR
... |..| .  .|| ||.  .. . ||||||..  |   |  |||| |....         .|| |. ||. . .||||.|.| ...     ||.|.| 
mdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

NAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRL-ITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIH
..   |.|. ..|.  .   .. . | .| . ...|  . .|| | |.| . .|. .. ..|....|..|. || ..||  |. || .| |.... | | 
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkia

SHFTLPDIKQIVSHLRVTgRAASVQTLQQYML-IWKVLLDFGVAYKQITEELAE-KFNATY
       ...... ||   ||  ... ...   .  ..| .  ...|..||  | | .| .
etsgsvkledvlkalrkq.ralaitsalelafvdagivllaievldqfaeeetekkakaee

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 287-376 4.4e-08 26.8 In-house 51-156 (349) alignment
Range on Protein: 287-376
Range on HMM: 51-156/349.0
KNRYLNIPCLDISRVQLKVMPNK--------------NSTDYIHANYIRSPFLK--RGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCA
|||| .|   . |||.||  ..                  ||| |||.. . ..  . || || |   |  ||...|  ..   .. | .  |.. ||| 
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

EYFPRN
 |.   
iywqel

subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 287-382 6.7e-06 17.9 In-house 48-139 (327) alignment
Range on Protein: 287-382
Range on HMM: 48-139/327.0
KNRYLNIPCLDISRVQLkvmpnKNSTDYIHANYIRSPflKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC---QFTETNREKCAEYFPRNAHCCLQ
 |  | ||  |  ||           ...  .|.|       ||. | | |..    ||.| ..    .| ||   |.. ..  ||  ||| .    ..
vnvrlpipirdnrrvlc.....gsdeeffpgqyvrme..gaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkme

0044763 (Phosphotyrosine protein) phosphatases II 295-507 1.1e-28 95.4 In-house 1-163 (178) alignment
Range on Protein: 295-507
Range on HMM: 1-163/178.0
CLDISRVQLKVMPNKNSTDYIHANYIRsPFlkrgYILTQGPKketrADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHcclqfdkmsvsyedst
.|| .|| |  ... ...|||.|..|  |.    ..|.. |     ||......... |.||.|.. .| ...|| .|.|..|.                
pldrtrvllsnleglersdyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

vnkslvttrlnlsyegetrliTHWLWKEWPDWQVPGSSEVMLKILRKIR----ARSTPPVIHCSAGVGRSGTLMAVEIALQSihsHFTLPDIKQIVSHLR
                      ..|.  .||. || ..| .|.... |.     .  | ..||||||||||||.|  . ..    ...|... . |   |
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl...glsleeaielvrerR

vtgrAaSVQTLQQYMLI
       |..  |.  .
....p.ivpnpgqlrqL

subfamily_eak_pd Subfamily eak 296-435 3.7e-15 50.1 In-house 63-201 (332) alignment
Range on Protein: 296-435
Range on HMM: 63-201/332.0
LDISRVQLKVmPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDStV
 |   |.|     .|   || |  .  . . | ||||  ....    ||.|. .... |||.| .  | . ||   ||| ...  |.| .. |   .  |
ydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.v

NKSLV-TTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVM
... . |  | ||   ||  . |.    | . ..|   . .
krniletrllelskGnethrvlhykvfGwtettlpkyedfl

0046846 (Phosphotyrosine protein) phosphatases II 306-510 2e-34 114.2 In-house 6-168 (176) alignment
Range on Protein: 306-510
Range on HMM: 6-168/176.0
MPNKNSTDYIHANYIRSPFlkrgYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLqfdkmsvsyedstvnkslvttrln
.   .. |||.||.| ...    .| ||||  .| |||..|..... ||.|.|.. .|..| ||. |.|.     .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lsyegetrlitHWLWKEWPDWQVPGSsEVMLKILRKIRARS---TPPVIHCSAGVGRSGTLMAVEIALQSihshfTLPDIKQIVSHLRVTGRAASVQTLQ
           ..|.  ||| .|| . | .|..|. || .     | ..|||||.||.||| |  .   .        .. ......|   .  .||| .
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpe

QYMLIWKV
||  . ..
Qyrflyef

0043147 (Phosphotyrosine protein) phosphatases II 310-508 2.1e-36 120.6 In-house 3-154 (172) alignment
Range on Protein: 310-508
Range on HMM: 3-154/172.0
NSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFtetnrekcaeyfprnahcclqfdkmsvsyedstvnkslvttrlNLSYE
...|||.|.|.  ..  . .| ||||  .| ||||||..... |.||.|...                                            . .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GETRLITHWLWKEWPDWQVPgSSEVMLKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALqsihSHFTLPDIKQIVSHLRvtgrAASVQTLQQY
...||. ..|.  |||  || ..|..|..|. |.      .. | ..||||||||.||| |  . |     ...| .. . | . |      .||. .||
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lglsleeavalvrekR....pgavqnpsqy

MLIW
... 
rfly

0051429 (Phosphotyrosine protein) phosphatases II 311-525 2.7e-37 124.2 In-house 3-235 (272) alignment
Range on Protein: 311-525
Range on HMM: 3-235/272.0
STDYIHANYIRSPFL---KRGYILTQGPKKETRADFWRMiWQENTTAIVMLCQFTETNREKCAEYFP----------RNAHCCLQFDKMSVSYEDSTVNK
 ..||.|...  ..    .. .....|| . | |||||. .... ..||.|.. .| .|.||  | |           ...    . ...| .   ..  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

SLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSevMLKILRKIRArSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPD-------IKQIVS
  . ..| |.   . ||.| ..|...  |||  || ..  .|..|. ... . | ..|||||..|.||. |. . |. .. .  . |       . ..|.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

HLRVTGrAASVQTLQQYMLIWKVLLDFGVAYKQITEEL
.||    ...||| .||. ....||..  .. .. .| 
elraqr.pgavqteeqylflyeallellrsllsvraey

0036282 (Phosphotyrosine protein) phosphatases II 312-508 3.1e-36 120.1 In-house 2-163 (174) alignment
Range on Protein: 312-508
Range on HMM: 2-163/174.0
TDYIHANYIRSPFLKRGYILTQGPKKetradFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRnahcclqfdkmsvsyedstvnkslvttrlnlSYEGE
.|||.|...      ...|..||| .     ||.|..... |..|||..  | ...||  |.|.                                .| .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TRLITHWLWKEWPDWQVPGSSEvMLKILRKIRAR-----STPPVIHCSAGVGRSGTLMAVEIALQSIHshFTLPDIKQIVSHLRVTgRAASVQTLQQYML
.||. ..|.  ||| .|| .|. .|.... ..       . | ..||||||||.|||.|  . |. ..   .| |. ..|  ||   |  .||| .||. 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlq.rpgmvqtpsQyrf

IW
. 
ly

0051082 (Phosphotyrosine protein) phosphatases II 312-511 3.6e-29 96.7 In-house 3-149 (151) alignment
Range on Protein: 312-511
Range on HMM: 3-149/151.0
TDYIHANYIRSPflkrgYILTQGPkketRADFWRMIWQENTTAIVMLCQFTETNreKCAEYFPRNAhcclqfdkmsvsyedstvnkslvttrlnlsyege
.|||...|. .      .....||     |||........ ..||.|.. .|..  .|.||.|..                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

tRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR-STPPVIHCSAGVGRSGTLMAVEIALQSihshftlPDIKQIVSHLRVTGRaASVQTLQQYMLIWKV
 . ..|. .  ||| ..| | . .|..|.....  . | ..|||||.||.|||.|. . |.         .. ......| .    .||. ||.... ..
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrp.gvvqpnqqflfqlfa

L
|
l

0049260 (Phosphotyrosine protein) phosphatases II 326-508 5.6e-31 102.7 In-house 8-143 (152) alignment
Range on Protein: 326-508
Range on HMM: 8-143/152.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFprnahcclqfdkmsvsyedstvnkslvttrlnlsyegetrlitHWLWKEWPD
.. .| ||||  .| ||||||... . |.||||....| ...||..|.                                           ..|.  |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpD

WQVPGSSEVMLKILRKI----RARSTPPVIHCSAGVGRSGTLMAVEIALqsihSHFTLPDIKQIVSHLRvtgrAASVQTLQQYMLIW
  || .|...| .|. |    . .. | ..||||||||.|||.|  . |     ...| .. . |   |      .|.. .|.... 
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml....lgvsleeavalvrekR....pgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 326-510 5.7e-17 56.5 In-house 3-198 (198) alignment
Range on Protein: 326-510
Range on HMM: 3-198/198.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTeTNRE-KCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS----YEGETRLITHWLW
.| || || | .|| ||||.|.|.  .  |||. .    |.|   . |.|     . ..  .||. .  |..   . | | |.        || |.|. .
qrryiatqhplretladfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KEWPDWQVPGSSEVM------LKILRKIR-ARSTPPVIHCSAGVGRSGTLMAVEIALQSI-HSHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKV
  | .   |  .  .       .. .|    . .| ..||| | | .| ..|..| ..|   |. .. |. ..   ||   |   . .||.| .|..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrq.arcgiisslqhynfiyqv

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 326-510 6.2e-17 56.4 In-house 4-199 (199) alignment
Range on Protein: 326-510
Range on HMM: 4-199/199.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTeTNRE-KCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS----YEGETRLITHWLW
.| || || | .|| ||||.|.|.  .  |||. .    |.|   . |.|     . ..  .||. .  |..   . | | |.        || |.|. .
qrryiatqhplretmadfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KEWPDWQVPGSSEVM------LKILRKIR-ARSTPPVIHCSAGVGRSGTLMAVEIALQSI-HSHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKV
  | .   |  .  .       .. .|    . .| ..||| | | .| ..|..| ..|   |. .. |. ..   ||   |   . .||.| .|..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrq.arcgiisslqhynfiyqv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 326-426 9.1e-10 32.4 In-house 235-331 (440) alignment
Range on Protein: 326-426
Range on HMM: 235-331/440.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFtetNREKCAEYFPRNAHCcLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPD
|  .| || |   |  ||||.. . . ..|.|| |.   |   |. |.| |.   . |  ..| .  |   . .    |.| |  |   |  .  . || 
knafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwpt

W
|
w

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 327-515 2.8e-28 93.7 In-house 35-221 (255) alignment
Range on Protein: 327-515
Range on HMM: 35-221/255.0
RGYILtqgpkkeTRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDsTVNKSLVTTRLNLSYEG---ETRLITHWLWKEW
  |.|       | . |...| | .|. .|||| |.| ..||| .||| .    |.. ...|.  . .... .. |.  .|. |   .|. ..|. .| |
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGW

PDWQVPGSSEVMLKILRKIRArSTPPVIHCSAGVGRSGTLMAVEIALQ----SIHSHFTL-PDIKQIVSHLRVTGRAAsVQTLQQYMLIWKVLLDFG
.. . |  .. .|.||. .|  | . |.|||.|.||| ... .|.. |    |..   |   | .... .|| . ..| ..|  |  .   ..||. 
ieknaPelareilnilkvvrd.sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkra.ihtPlqlafsilmvldlv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 334-507 3.6e-23 76.4 In-house 98-280 (302) alignment
Range on Protein: 334-507
Range on HMM: 98-280/302.0
GPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYED-------STVNKSLVTTRLNLSYE----GETRLITHWLWKE
 |||.|.  .| .| | |.. .| ||.| | . .|||||.  .    |.| . .|   .        |  ||..   ...  |       . .   ..  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLI
|||   |  ..  |.||.   .  .  ..||||||||.|||.|.   .|    .    |. .||  .|   |  .||. || . .
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskk.kvtdllsivlpvrq.cryGavqdeqqliyl

subfamily_hpo-7_pd Subfamily hpo-7 339-514 8e-24 78.9 In-house 46-226 (263) alignment
Range on Protein: 339-514
Range on HMM: 46-226/263.0
TRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVnKSLVTTRLNLSYEG---ETRLITHWLWKEWPDWQVPGSSEVM
| . |...| | .|. .|||| |.| ..||| .||| .    ... ...|.  ..   . |. |.  ||. |   .|. ..|. .| |.. . |  .. .
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LKILRKIRaRSTPPVIHCSAGVGRSGTLMAVEIALQ----SIHSHFTL-PDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
|.||.  |  | . |.|||.|.|||     .|.. |    |..   |   |  ... .|| . |.....|  |      ..|||
lnilkvar.nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrss.rkraihtPmqLafsilmvLdf

0048179 (Phosphotyrosine protein) phosphatases II 400-507 1.3e-16 56.1 In-house 34-137 (144) alignment
Range on Protein: 400-507
Range on HMM: 34-137/144.0
VTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---STPPVIHCSAGVGRSGTLMAVEIALqsihsHFTlPDIKQIVSHLRVtGRAA
.. . .  .| ..| ....|.  |||..|| ..| .|..|. |..    . | ..||||||||.|||.|  . .     ..   ...... ..|   |  
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrs.rrpg

SVQTLQQYMLI
.|.. .|.. .
avpnpgqlrfL

0048076 (Phosphotyrosine protein) phosphatases II 401-510 4e-17 57.7 In-house 31-138 (145) alignment
Range on Protein: 401-510
Range on HMM: 31-138/145.0
TTRLNLSYE--GETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---STPPVIHCSAGVGRSGTLMAVEIALQsihshFTlPDIKQIVSHLRVTgRA
|| |||..|  ...||....|.  |||..|| ..| .|..|. |..      | ..||||||||.|||.|  . |.     .   .. ... ..|   | 
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsq.rp

ASVQTLQQYMLIWKV
 .|.. .|.  . ..
gavpnpgqlrflyef

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 401-513 7.4e-10 32.7 In-house 75-192 (440) alignment
Range on Protein: 401-513
Range on HMM: 75-192/440.0
TTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKI-----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtG
.  .| ||    |.| . .. .. |||  ||  .  .||... .     .| . | ..|||||.||.| ..||.  |.  .    . ||  ... .|   
sdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrn.n

RAASVQTLQQYMLIWKVLLD
|   ||| .|| .. ...|.
rpqmvqtpeqyafvheavle

PTPc_DSPc_SM00012 415-512 6.2e-24 79.6 In-house 2-104 (105) alignment
Range on Protein: 415-512
Range on HMM: 2-104/105.0
ITHWLWKEWPDWQVPGSSEVMLKILRKIRARST------PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIW
..|  ...||| .|| .|. .|..||...   .      | |.||||||||.||..|..|.||..... . .||.|||..|| . |. .|||..||. . 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr.kqRpgmvqteeqylfly

KVLL
..||
rall

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 437-512 5.5e-14 46.7 In-house 219-292 (297) alignment
Range on Protein: 437-512
Range on HMM: 219-292/297.0
KILRKIRARSTPPVIHCSAGVGRSGTLMAVEIaLQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
. ||    |... ..|||||||||| ..  .. . ..  .  .||.. |.|.||   ||  ||||.|. |.... |
eslraemprnayllvhcsaGvGrsGvvvlsdv.ilaklrkkripdvaailsilr.eqrarlvqtleqfellydavl

subfamily_CG42327_pd Subfamily CG42327 444-515 7e-15 49.5 In-house 245-315 (319) alignment
Range on Protein: 444-515
Range on HMM: 245-315/319.0
ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFG
 .  | |.||| ||||.|...| .||..|.       || |.||..|  .|| .|.| .|| .|.|||  . 
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvr.rdrasavltkeqyefiykvlseya

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 444-514 3.2e-08 27.7 In-house 260-343 (350) alignment
Range on Protein: 444-514
Range on HMM: 260-343/350.0
ARSTPPVIHCSAGVGRSGTLMAVEIALQ------SIHSHFT--------LPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||.| ..|||||||| |||....  |.       .  ...           |..|| .||   |   ||.|.|.. |.. || .
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelr.kqrismvqnldqfifiYeallfy

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 450-511 1.8e-06 22.2 In-house 1-60 (69) alignment
Range on Protein: 450-511
Range on HMM: 1-60/69.0
VIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVL
|.|||.| ||.||..|. . .  | |   | ||   | ..|   |   |    .||.|   |
vvhcssGtGrtGtfiaimvemarikse.klvdifnnvqymrk.crpmmvmneneymfihdal

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 450-511 2.8e-06 21.6 In-house 2-61 (69) alignment
Range on Protein: 450-511
Range on HMM: 2-61/69.0
VIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVL
|.|||.| ||.||..|. . .  | |   | ||   | ..|   |   |   ..|..|   |
vvhcssgtgrtgtfiaimvemarikse.klvdifnnvqymrk.crpmmvmneieyifihdal