Gene ZK783.5 in Caenorhabditis elegans

Synonym: CELE_ZK783.5, ZK783.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP241_AA protein Get Run
CeleP241_AA_3-186 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1-222 3.4e-166 546.0 In-house 125-346 (346) alignment 
Range on Protein: 1-222
Range on HMM: 125-346/346.0
MENESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
menesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppkt

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKRGGKKAPVNKDI
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
lpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdi

KRFINELTEISPACSPTKVMPL
.|||.||.||||||||||||||
nrfidelaeispacsptkvmpl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-186 1.3e-14 48.7 In-house 95-278 (315) alignment 
Range on Protein: 2-186
Range on HMM: 95-278/315.0
ENESFVEDFWYMIYQEQIHLVYlMVPDDKL--KNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIeVLPEGNSDSVICQVHHHApWKHLQQPPK
 ... |.||| |..||..  .  || . .   |      . |...     |.. ..    .  .|     . |. ....   . | . .  | .   . .
Plkasvddfwrmvlqekvttiv.mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqfte.wPdkGvdkq

TLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
|  ..|.|..  .... ..  . |  . | ||.  .| .   ..|....   .. ...||....||  | .  .|| || .| ... 
tssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-186 1.4e-14 48.1 In-house 95-277 (515) alignment 
Range on Protein: 3-186
Range on HMM: 95-277/515.0
NESFVEDFWYMIYQEQIHLVYlMVPDDKLKNT--TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNsDSVICQVHHHaPWKHLQQPPKT
|.. |.||| ...||..  .  || . |  .    .  . |  |     |.. ..    .  ..    ...|| . .    . | | .  | .   |..|
nkasvddfWrlvlqenvttia.mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhft.eWPdkGvpkht

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
  ..|.|..  ....  .  . .  . | ||.  .| .   . . ...   .. ....||.|.||  |    ||| || .| ... 
ssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-186 6.5e-14 46.7 In-house 101-285 (297) alignment 
Range on Protein: 3-186
Range on HMM: 101-285/297.0
NESFVEDFWYMIYQEQIHLVyLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHH-APWKHLQQPPKT
... |.||| |...||.  . .|. ||. ..     .  ..|  .  |.. .     .      . ..||  .   .  |. | ..   | |  ..  ..
mkatvadfWamvldeqvsti.vmlnddnerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

LPIIKMIHQFLSEKQVQNA-GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
  ..|.|..   . . ..   . |  | | ||.  ..  .  . . ..  | .| ...| ..|.||  |    ||. .| .| ....
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-186 1.9e-10 35.4 In-house 100-290 (325) alignment 
Range on Protein: 3-186
Range on HMM: 100-290/325.0
NESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWK--HLQQPPKT
. . ..|.| .... .  .| ..   |. |.  .  . .| |  .  | . .. | ..   |     ..|    . ..   .  ..  |.    |. | |
ltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpat

LPIIKMIHQFLSEKQV----QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI-S
|  |  . . .||.        . . |    | ||.  ||    |.... .  . .| . .|.....||  ||.  ||  ||  . ... |
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-184 2.2e-09 31.2 In-house 97-235 (392) alignment 
Range on Protein: 3-184
Range on HMM: 97-235/392.0
NESFVEDFWYMIYQEQIHLVyLMVPddKLKNTTtslfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQVhHHAPWKHLQQPPKTLP
| . ..||| |..||..  .  ||   |||.                                          |...  ..|  | . |   . | .|  
naaslddfwrmvfqenvtti.amvt..klkegd.......................................kgddartvaqf.hftewPdkdvpkhtss

IIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
..|.|..  ..       . .    | ||.   |     . . ..    .. ... ||...||  |..  ||| ||. |.. 
llkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4-188 7.1e-54 177.3 In-house 103-288 (302) alignment 
Range on Protein: 4-188
Range on HMM: 103-288/302.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPK-EYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLP
|. ||.|| |..||.|  |...| ...||.|   ||  . | |.. ||||.|||. . . . | .|.||||||| |.||...| ..  ||. . | |   
edsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae

IIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
.|| ...   .|.  .. . .||  |.||| .|. .  |...|..| |||| ||.|.|..|||  |.|. ||.|.| ..  || .|
liktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
Y_phosphatase Protein-tyrosine phosphatase 4-182 9.6e-43 141.6 Pfam-A 52-234 (235) alignment 
Range on Protein: 4-182
Range on HMM: 52-234/235.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPP
.|..|||| |..||......... ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | 
kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpe

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
.. .....|... ..|. ... |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..||. .|....
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 4-182 9.6e-43 141.6 In-house 52-234 (235) alignment 
Range on Protein: 4-182
Range on HMM: 52-234/235.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPP
.|..|||| |..||......... ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | 
kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpe

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
.. .....|... ..|. ... |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..||. .|....
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0040438 (Phosphotyrosine protein) phosphatases II 4-221 1.3e-39 131.7 In-house 96-310 (317) alignment 
Range on Protein: 4-221
Range on HMM: 96-310/317.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPI
.. ||||| |.........  ... . |.. .   .  . |.... |.......  .. .. . .|.|| . |.|.|......|.  | .   || . ..
pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIsrKRGGKKAPVNKDIKRF
......  .  . ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|....||  .| ....|.  ||.... |... ....
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..krkltlepaselklkl

INELTEISPACSPTKVMP
...|... .  .. |...
lklliplalddvklkeke
0036941 (Phosphotyrosine protein) phosphatases II 4-190 5.8e-39 129.6 In-house 88-282 (297) alignment 
Range on Protein: 4-190
Range on HMM: 88-282/297.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADV--SGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKT
.. ||||| |....... .  ..... | ...  . . .|.|.... |........ .|  ..| . .|.||.. ||..| .....|.  | .   |. .
pntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpesp

LPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLN---NGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKRG
 .....|.....  .   ..  |.| .  |.||...||.| ....||.      ...|.|..| ...|||| |... ||  .| ...... .|. 
aslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
DSPc_SM00195 4-185 1.7e-38 127.8 In-house 79-262 (263) alignment 
Range on Protein: 4-185
Range on HMM: 79-262/263.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTL
.| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | .| 
pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstk

PIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....||. || .. .||
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 4-185 1.7e-38 127.8 In-house 79-262 (263) alignment 
Range on Protein: 4-185
Range on HMM: 79-262/263.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTL
.| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | .| 
pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstk

PIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....||. || .. .||
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 4-185 1.4e-35 118.5 In-house 98-277 (278) alignment 
Range on Protein: 4-185
Range on HMM: 98-277/278.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPI
.. ||||| |....... .  ..... |....   .    ||... |........ .. .| . .|.|| . |.. | .....|. .| . . |. . ..
petvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.........  . .|  |.| .  |.||.. ||.......||... .....|..| ...|||| |... ||  .| ....|.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 4-189 1.3e-34 115.4 In-house 111-293 (297) alignment 
Range on Protein: 4-189
Range on HMM: 111-293/297.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGgyqYTGKMFINNRRADVSGDPKEYTIEVLPegNSDSVICQVHHHAPWKHLQQPPKTLPI
.. ||||| |....... .  . . . |...  . . .| |   . |........ .. .. . .|.|| .  |. | ....... .| . . || .  .
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslell

IKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
......  .  .   ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|... ||  .| .......||.
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Ptp69D_pd Subfamily Ptp69D 4-187 1.8e-17 58.4 In-house 101-288 (307) alignment 
Range on Protein: 4-187
Range on HMM: 101-288/307.0
ESFVEDFWYMIYQEQIHLVyLMVPDDKLKNT--TTSLFNDEnGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG------NSDSVICQvHHHAPWKHLQ
|. ..||| || . ...|.  |. . . ||       . .|    ||  .. ..  . .  .|  . ...|   .      .    . | .|.  ||  .
eatigDfWRmiaeqevtli.vmlsnlteknrkkcakYWpie.devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvq.yhytgWkDsk

QPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
 |  .  ..|.|.|  . .. ... . |    | ||.  |.     ..||..  . .|.|..|....||.  |.|..||  .|  . ||.| 
vPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_CG7180_pd Subfamily CG7180 4-185 9.7e-16 52.2 In-house 95-290 (296) alignment 
Range on Protein: 4-185
Range on HMM: 95-290/296.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSlFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPE----------GNSDSVICQVHHHAPWKH
.. |..|| ..|.|.|. |  .      ..   | .  ...  || |..|..  . .   . | .|. .  .           . .  |... .   |. 
ketvdefWrlvydeeisavvvLtktfdfakmyps.ywpnkskeqy.geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWel

LQQPPKT----LPIIKMIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 .. |      . ........  .   . ... |.|||  | .|.  ....  .......  | .. | .| ....||. ||.  .|  || .. ...
edkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0050432 (Phosphotyrosine protein) phosphatases II 5-188 1.6e-37 124.9 In-house 119-302 (308) alignment 
Range on Protein: 5-188
Range on HMM: 119-302/308.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLK-NTTTSLFNDENG-GYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLP
. ||||| |.........  .   .  . ..    . .| | |... ||....... .| .| . .|.|. . |...| .... |.  |.. . ||.. .
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

IIKMIHQFLSEKqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
.......  .    ..  ..| .  |.||.. || ......||. . .....|..| ...|||| |... ||  .| ....|...|
lldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0046845 (Phosphotyrosine protein) phosphatases II 5-189 3.1e-36 120.6 In-house 88-278 (284) alignment 
Range on Protein: 5-189
Range on HMM: 88-278/284.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKTLPI
. ||||| |.........  . . .  ...  . .  ..|.... |........ .| .| . .|.|. ..| .. |......|. .| . . || . ..
ntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedl

IKMIHQFLSEKQ--VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI---EPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
......  .  .   ..  ..| .  |.||.. || . ....||...    .....|..| ...|||| |....||  .| ....|...|.
leflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 5-185 2.7e-35 117.6 In-house 103-286 (288) alignment 
Range on Protein: 5-185
Range on HMM: 103-286/288.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAPWKHLQQPPKT
. ||||| |.........  . . . |....   .  . ||... |........ .| .| . .|.|| .     |.. | .....|.  | . . |. .
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 ......... .  . ..  |.| .  |.||.. || ......||... .....|..| ...|||| |... ||  .| ....|.
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 5-187 1e-32 109.5 In-house 118-306 (307) alignment 
Range on Protein: 5-187
Range on HMM: 118-306/307.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GNSDSVICQVHHHAPWKHLQQPPKTLPI
. ||||| |.........  . ... |..     .  ..|.... |........ .. .. . .|.|| .  |.. | .....|.  | . . || . ..
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

IKMIHQFLS--EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIE---PNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
...|.. ..  |.  ..  |.| .  |.||...||.|.... ||... .   ... |..| ...||||.|... ||  .| ...... .
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
0040439 (Phosphotyrosine protein) phosphatases II 5-186 2.5e-32 107.8 In-house 65-247 (249) alignment 
Range on Protein: 5-186
Range on HMM: 65-247/249.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPII
. ||||| |.....|. .  . ... |.. .   . .. ||... |........ .|..| . .|.|. . ....|. ... .. .| . . || . ...
etvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedll

KMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
..|.. ..  .   ..  |.| .  |.||.. ||.|.....||.   . .. |..| ...||||.|... ||  .| ...... 
dfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 5-186 4.2e-32 106.9 In-house 63-244 (245) alignment 
Range on Protein: 5-186
Range on HMM: 63-244/245.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTL
. ||||| |.....|. .  . ... |.  .   .  . |.....|........ .. .| . .|.|| ..|.. |  ....|. || . . |.     |
etvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllelll

PIIKMIHQFLSEkqVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
 ........|.|   .|  |.| .  |.||.. ||.|.....||.   . .. |..| ...|||| |... ||  .| .......
dflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 5-184 3.5e-21 71.3 In-house 55-241 (243) alignment 
Range on Protein: 5-184
Range on HMM: 55-241/243.0
SFVED----FWYMIYQEQIHLVYLMVPDD-KLKNTTTSLFNdenGGYqYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPP
. |||    || |.....|. .  . ... . ..    ...   |.. . |......    . .| . .|... . . .  .   . .|. || . . |.
etveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPd

KT---LPIIKMIHQFLSE-----KQVQNAGVCVVSLFGCGRACSFIGALYAINQLnngiEPNICEIMKNIKQQRPG-GVESFAQYASIYAIVFDY
 .   | .......|..|     .  ..  |.|    |.||.  .| |.. . .|    . .. |..| ...|||| .|... ||  .| ..  .
spedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 5-188 3.9e-18 61.3 In-house 75-275 (278) alignment 
Range on Protein: 5-188
Range on HMM: 75-275/278.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAPWKHLQQPPKT
| |.||| |.....|. .  . .   |..     .  | ||... |......   .| .|    |..|        .  |   ...|  ||     |. .
stvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslp

--LPIIKMIHQFLSEKQV-------------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEpnICEIMKNIKQQRPG-GVESFAQYASIYAIVFDY
   ...... . ..  ..             ..  | |    |.||.. ...| . . .|..|.   . |. | ...||||  |... ||  .|  . ..
ilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd..lleavkelrsqRpglavqnleqyrflyefllel

ISRK
..|.
llrg
subfamily_PTPRA_pd Subfamily PTPRA 5-185 8.2e-15 49.5 In-house 112-295 (330) alignment 
Range on Protein: 5-185
Range on HMM: 112-295/330.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTG-KMFINNRRADVSGDPKEYTIEVLPEGN---SDSVICQVHHHApWKHLQQPPKT
  ||||| ||.. . . . ..   .. |..    .  ..| . |   .. ...    |.   ... .. ||..    .  .. |.| .. | ..  | ..
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhfts.wPdvGvPfep

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
  ..|....  . .|..   . |    | ||. .||     .....     .. |..|....|||  | .  ||  || .. .| 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 5-186 1.4e-14 49.0 In-house 100-284 (305) alignment 
Range on Protein: 5-186
Range on HMM: 100-284/305.0
SFVEDFWYMIYQEQIHL-VYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLP-EGNSDSVICQVHHHAPWKHLQQPPKTLP
. |.|||..|..|...  | |    .  |.     . .. .  .  |.. .. .      |  |  ...   .....|     ..   |     | ..  
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

IIKMIHQFLSEKQVQ-NAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
....|..   ... . .  . |.   | ||.  ||    |...|..  . .. |..|.....|.. |.. .|| ... .. ..| 
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 5-185 3e-14 47.8 In-house 101-279 (288) alignment 
Range on Protein: 5-185
Range on HMM: 101-279/288.0
SFVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDENGgYQYTGKMFINNRRADVSGDPKEYTIEVLpEGNSDSVICQVHhHAPWKHLQQPPKTLPI
. |.||| ..|..... .  .    .. |..    . |..   .  |.. .  .     .|  . ....    ...  | | . .  |   . |  . |.
dtvndfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrkllle.kkkteleitqyq.ylaWpdhgvPeskapl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.....|    .| .   . |.   | ||.  || .  .|.....    ...........||.  |.   ||  || .. . |
lellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPRK_pd Subfamily PTPRK 5-183 1.6e-11 38.6 In-house 97-275 (314) alignment 
Range on Protein: 5-183
Range on HMM: 97-275/314.0
SFVEDFWYMIYQEQIHLVyLMVPD--DKLKNTTTSLFNDENGGYQYTGKMFINNrRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLP
. |.||| ..|.|.   . .|. .  .. .   .  . ..   |.    ....   ..     . ...| |  | ..  . .  ..  | . . | .   
etvkdfWrlvydencasi.vmltelvevgrvkClkyWPedtevygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

IIKMIHQFLSeKQVQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
..|....  . .| ..||  ||  . |.||.  ||     .. ...    .. ...|.......  ||   ||  || ....
llklvrrvkk.sqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 5-182 2.5e-11 38.1 In-house 103-276 (315) alignment 
Range on Protein: 5-182
Range on HMM: 103-276/315.0
SFVEDFWYMIYQEQIH-LVYLMVPDDKLKNTTTSLFNDENGGYqytGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIcQVhHHAPWKHLQQPPKTLPI
. |.||| ....|.|  .| |    .. |. .   . |..  |   ||. .  .  .|  .    |. |  . |   |. |. |.. |   . |  |.|.
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy...Gkitvtrkseevnteytvrtlsvvfgdnirevv.ql.hytswpdmgvpkytipl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
...| .    .. . . . |    | ||. .||     ..|..     .. .......|.| . |.. .||  || ...
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
0047943 (Phosphotyrosine protein) phosphatases II 6-185 4.1e-35 117.0 In-house 89-272 (273) alignment 
Range on Protein: 6-185
Range on HMM: 89-272/273.0
FVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGG-YQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPI
 ||||| |.........  ..... | ...    . .|.|. ... ||....... .. .| . .|.|. . |...| .....|. .|   . || . ..
tvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesl

IKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
...|..  .  .   .|  |.| .  |.||...|| ......||. . .....|..| ...||||.|... ||  .| ....|.
lefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 6-187 8.6e-14 46.0 In-house 95-282 (288) alignment 
Range on Protein: 6-187
Range on HMM: 95-282/288.0
FVEDFWYMIYQEQIHLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVhHHAPWKHLQQ---PPKT
 . ||| |.|...  ..  |. .... |. . . .  ..|  .  |.. .  ..   ..   |.....  ....    .. . .   | .|     | . 
tlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetl

LPIIKMIHQ-FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN--NGIePNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
| ... ... . ....  .. . |  . | ||.  |     |...|.  ||. ..| .... ...||   |.  .|.   | .|  .. |
lqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngl.ldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 6-183 9.9e-14 46.5 In-house 80-253 (284) alignment 
Range on Protein: 6-183
Range on HMM: 80-253/284.0
FVEDFWYMIYQEQIHLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIE---VLPEGNS-DSVICQVHHHAPWKHLQQP
 ..||| ||.. ..  . |.               ...    .  |. |.. | .|      . .||..    .  .|.  |    . .|   | .  .|
tladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvp

PKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
  . ........   |..|. ..| . |    |.||.  .|     ......    .. .......|||.  |....||  ||. . .
dypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 6-183 1.4e-13 45.9 In-house 116-289 (319) alignment 
Range on Protein: 6-183
Range on HMM: 116-289/319.0
FVEDFWYMIYQEQIHLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIEV---LPEGNS-DSVICQVHHHAPWKHLQQP
 ..||| ||.. ..  . |.                .     .  |. |.. | .|      . .||..       .|.  |    . .|   | .  .|
tladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvp

PKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
  . ........   | .|. ..| . |    |.||.  .|     ......    .. .......|||.  |....||  ||. . .
dypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6-187 3.2e-13 44.4 In-house 103-285 (319) alignment 
Range on Protein: 6-187
Range on HMM: 103-285/319.0
FVEDFWYMIYQEQIHLVYLMVP-DDKLKNTTTSLFNDENggYQYTGKMFINNRRADVSGDPKEYTIEVlpEGNSDSV---ICQVHHHAPWKHLQQPPKTL
 .|||| |...|... | ..    .|||     ....||  ..  |.. ..    .   |     ...  . .|. |     . ...  |   . | |..
tiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl..nkkssevetRevkhfqyteWpdhdvPekat

PIIKMIHQFLSE-KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
 .......     .. |.  . |    | ||  .||    .......    .. ....... ||.  |.  .||  || .. .... 
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPN6_pd Subfamily PTPN6 6-189 4.6e-12 40.5 In-house 110-301 (306) alignment 
Range on Protein: 6-189
Range on HMM: 110-301/306.0
FVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGD--PKEYTIEVLPEGNSDSVICQVHHHApWKHLQQPPKTL-
 |.||| |..||. ... ..  . .. |.  .  . ||.   . .||. ..| . .   |   .| ...   ....   . | |... |     | ..  
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks.WPdhgvpkdpga

--PIIKMIHQFLSEKQVQNAG-VCVVSLFGCGRACSFIGAL---YAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
    .. ...  .| . ..|| ..|    | ||  .||        |..  . .. .| ...| ...|| | |   .||  .| ..  || .|.
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPRG_pd Subfamily PTPRG 6-189 6.8e-11 36.1 In-house 103-291 (563) alignment 
Range on Protein: 6-189
Range on HMM: 103-291/563.0
FVEDFWYMIYQEQIHLVyLMVPD--DKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLP----EGNS--DSVICQVHHHAPWKHLQQP
 ..||| ||.... ...  |...  .. ..     .     . .  |.. ..  . .|   . . |. .      ....  .    . .| . |   . |
tfddFWrmiWeqnvaii.vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

PKTLPIIKMIHQFlSEKQVQNAG-VCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
 ..|| ......  |  . ..|| . |    | ||.  .|     ..|...    |. ...| |. ||.  |..  ||  .. .. . |. | 
ehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske
subfamily_PTPN14_pd Subfamily PTPN14 6-188 2.9e-08 28.1 In-house 105-299 (300) alignment 
Range on Protein: 6-188
Range on HMM: 105-299/300.0
FVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDE--NGGYQYTGKMFINNRRADVS--GDPKEYTIEVLPEGNSDSVICQvhHHAPWKHLQQPPKT
 |.||| |.......|. ..  . .. |. . . | ..  .      ||  . ..  . |     . .... || ..  .|.     .. |   . |.  
tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl..qytDWpdhgvPeDv

LPIIKMIHQFLSEKQV---------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
 . .. .... | ..          ..  | |  . | ||.   | .   |. |... | .| .... ...||   |...|||  .| ..  |. . 
kgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 6-188 1.2e-07 26.1 In-house 94-274 (288) alignment 
Range on Protein: 6-188
Range on HMM: 94-274/288.0
FVEDFWYMIYQEQIHLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMF--INNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKHLQQPPKTLP
 .| .| |. ..... .  |    .| |. .   |  . |     |..   . ..|||.    |  .. .  ||.   .. ..| .  |..   | . |.
tieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhll.eWdddgvPenyls

IIKMIHQFlsekQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
 ..... .    .  .  . | |  | ||.  .|  | |...|       | ..... ...|   ...  ||  .. .|....  |
plrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 6-185 5.7e-07 23.3 In-house 103-279 (439) alignment 
Range on Protein: 6-185
Range on HMM: 103-279/439.0
FVEDFWYMIYQEQ-IHLVYLMVPDDKLKntttslFNDENGGyQYTGKMFInnrRADVSGDPKEYTIEV---LP---EGNSDSVICQVHHHApWKHLQQPP
 ..||| ...... ...| |    .  |      .   ..   . | . .   |.|   .  .|.|     .     .. .  . |.|. | | . . | 
ttddfwrlviekktvtivmltnlvesyk......ywpsdae.vcygdiav...rvdrnielpnyvirgfkvfnerdttekertvlqfhyia.wpdknvpa

KTLPIIKMIHQFLSEKQVQNAGVCVVS-LFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
..  ......   | .. .. |  ||    | ||. . |    |..||.   . .|  |.| ...||   |....||  ||  |.. |
qashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 6-194 1.8e-06 21.8 In-house 108-298 (305) alignment 
Range on Protein: 6-194
Range on HMM: 108-298/305.0
FVEDFWYMIYQEQIHLVYLM---VPDDKLKNTTTslFNDENGG-YQYTGKMFINNR-RADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKhlQQPPKT
 ...||.|. |...  . ..   |   ||| .    .   .|   .  . . ..|   .       |  | .|    | .    | |   |   . | . 
tidefwwmviqnkveqivmlcktvelgklkcaqy..wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhl.qwt..ewpdrg

LPIIKMIH-QFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN-NGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKRGGKKA
.|  |.   ..||  .  .  . |    | ||. . .   | ....  |   | . |..| ...||   ...  ||  |. ....|.  |   | |
vppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-185 2.9e-18 61.2 In-house 112-290 (298) alignment 
Range on Protein: 7-185
Range on HMM: 112-290/298.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKM
||||| |. .|.|  . .. .   |..|. . .  ..|  .| |.. .. .. .. .|    ...|  . ....   .  |.  |   . | ..  ....
vedFWrmvteedigtiVmltnleeldktkyhkywPdegkety.geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IHQFL-SEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
...   |..|  |. | |    | ||. .||     ......     . ...| ....||| |.. .||. || .| ...
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 7-186 4.3e-17 57.2 In-house 65-243 (250) alignment 
Range on Protein: 7-186
Range on HMM: 65-243/250.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKM
.|||| |...|..  . ..      ..| .  .   ..  .| |.. ..    .. .| .  .. .  . ..|..| .  |.  |     | ..  ....
iedfWrmvleeksgtivmLtnLkesektyhqywP.vekaeky.GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLel

IHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
...  ...|  .|| | |    | ||. .||     ...|..    .. ...| ....||. ||| .|| ..| |.  .. 
lkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN12_pd Subfamily PTPN12 7-188 6.7e-17 56.3 In-house 96-280 (290) alignment 
Range on Protein: 7-188
Range on HMM: 96-280/290.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPkeYTIEVLPE--GNSDSVICQVHHHApWKHLQQPPKTLPI
..||| ||.. ....| ..     |. .    .  |.|. .  .|.. ... . .   |   ..|  |     .   .. | |..| |   . | .. ..
lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd..flirtLkveaqkesrkvyqfhYta.WPDhgvPssaksl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP---NICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
...|... . .. ..| ..|    |.||.   |   |. ..|.... |   .. ... ....||.  | .  ||  .|  | ......
lelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 7-187 4.9e-16 53.6 In-house 86-270 (274) alignment 
Range on Protein: 7-187
Range on HMM: 86-270/274.0
VEDFWYMIYQEQIHLVyLMVPDDKLKNT-TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPKTLPII
|.||| |||||..... .|. . | .|    . .  .. .|. ...    . . .   . ..|... |   .. .   .. . .. |   ..| .. ...
vadfWrmiyqeevqvi.vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantll

KMIHQFLS---EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
.....  .   |.. . | | |    | ||.  ||... |..||.. |  .. .|. |....| | |..  ||  |. ..  | .|
dlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRD_pd Subfamily PTPRD 7-212 1.2e-14 48.9 In-house 104-305 (564) alignment 
Range on Protein: 7-212
Range on HMM: 104-305/564.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKM
.|||| |....... . ..      ...  . .  |.|  .| |.. ..        |    |...  . .|.|   .  |.  | .  .| .. .....
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

IHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRkrGGKKAPVnKDIKRFINE
|..  . .. ..  . |    | ||   ||   . ......    .| ...|....||.  |..  ||. |. .. ....   | .. .. ...|. ...
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac..gnteves.enlkqhlqk

LTEISP
|.|...
Laevee
0041856 (Phosphotyrosine protein) phosphatases II 7-187 3.2e-14 48.4 In-house 47-173 (182) alignment 
Range on Protein: 7-187
Range on HMM: 47-173/182.0
VEDFWYMIYQEQIHLVYLMVpddklkntttslfndengG----YqytgkM-FinnrradvsgdpkeytievlpegnsdSVICQVHHHAPWKHLQQPPkTL
|.||. |.....|...  .                   .    .       .                                ... ||     |. . 
vadflrmlkelgittivnlt..................eelywp.....ell..........................erlgiqylylpwpDhgvpd.ld

PIIKMIHQFLSekqvQNAGVCVVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
 ....|.. |.    ..  | |    |.||......| . . .     . .. |..| ....|||.|..  ||  .. ...... .
elldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 7-186 1e-13 46.0 In-house 99-279 (287) alignment 
Range on Protein: 7-186
Range on HMM: 99-279/287.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGyQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKTLPIIK
. .|| .| ..... . ... .   ..     .  |.    . |.  |.    .|. .  | ..||  .. ..|    . .. . |.   . ..   |. 
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

MIHQFL-SEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
.|..   ....  |. . |    . ||.  |. |  .||. ..    .. ...|. ..|.|| |   .||  |. ||  |..
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-186 3.4e-13 44.1 In-house 104-284 (290) alignment 
Range on Protein: 7-186
Range on HMM: 104-284/290.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGDPKEYTIEVLPEGN--SDSVICQvHHHAPWKHLQQPPKTLPII
. ||| .|.||..  . ...   . ....   .  ...  .  |.. |.     .  .  | ..||  . .  . . . | ..   |..  . ...  |.
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtq.yqitnwdstgkvtnpqtil

KMIHQFLS-EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
 .|..    ...  |  . |    . ||.  |. |  .||. .     .. ...|. ..|.|| |..  ||  |. ||. |..
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-218 3.9e-13 44.2 In-house 102-310 (318) alignment 
Range on Protein: 7-218
Range on HMM: 102-310/318.0
VEDFWYMIYQEQ-IHLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIK
.|||| |... .   .| |    .. |.     .  ..|  .| ||. .. .    ..|    ...|  .....| . . .|.. |     | ..  ...
ieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

MIHQFLSEKQVQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRkrgGKKAPVNKDIKRFI
.. |  . .| ..||. ||    | ||.  ||     ......    .. ...|....||.  |    ||  || .. ...     |..    .|... |
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas...gdtevdasdlrsri

NELTEISPACSPTK
.||.| .|    |.
relreqdpesgtte
0043147 (Phosphotyrosine protein) phosphatases II 7-178 1.3e-12 43.2 In-house 33-154 (172) alignment 
Range on Protein: 7-178
Range on HMM: 33-154/172.0
VEDFWYMIYQEQIHLVYLMVPDdklkntttslfndenggyqytgkmfinnrradvsgdpkeytievLPEGNSDSVICQVHHHAPWKHLQQPpkTLPIIKM
..||| |.....|.... . .                                             |  .   .     ... ||     |  .| ..  
ladfwrmlkelgithivnltel............................................lydpellerlgiqylylpwpDhgvp..llellle

IHQFLSE--KQVQNAGVCVVSLFGCGRACSFIGALYAInqlnNGIepNICEIMKNIKQQRPGGVESFAQYASIY
. .|. |   . ..  |.|    |.||.. .. |.. .     |.  .. |... ....|||.|... ||  .|
flefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl..sleeavalvrekRpgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 7-183 2.6e-12 42.3 In-house 36-171 (176) alignment 
Range on Protein: 7-183
Range on HMM: 36-171/176.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKtlPIIKM
..||. |.....|..|  .  .  |.      . .|  ....                                     ..| ||   . |.    ..  
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl..ellle

IHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnnGIEPNICEIMKNIKQQRP-GGVESFAQYASIYAIVFD
. .|. | . ..  | |    |.||.. .. |.  .     .   .. |... ...||| | |....||  .|  .  
llefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefell
0049260 (Phosphotyrosine protein) phosphatases II 7-178 8.4e-12 40.5 In-house 22-143 (152) alignment 
Range on Protein: 7-178
Range on HMM: 22-143/152.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNdenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKTLPIIKM
..||| |... .|. .  .  .. |.   .                                                 ..| ||     |. .  .. .
ladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllfl

IHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAInqlnngIEPNICEIMKNIKQQRPGGVESFAQYASIY
..     .. ..  | |    |.||.  .. |.. .         .. |... ....|||.|... |.  .|
llfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 7-185 1.3e-11 39.1 In-house 88-270 (285) alignment 
Range on Protein: 7-185
Range on HMM: 88-270/285.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEN-GGYQYTGKMFIN---NRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPK-TL
. |||.|||||.|  | ...   .      .|.  |. |     ||  |     .   ..|   .    .  |  |   .   | . ||   |  |. . 
lsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedar

PIIKMiHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
|.|.. .... . . ..  .||    | ||...|.|  ||  .. .  . .. .|.....  |   |.|. |.  .| ....|.
pmiel.ykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_PTPRB_pd Subfamily PTPRB 7-189 1.9e-10 35.3 In-house 107-289 (293) alignment 
Range on Protein: 7-189
Range on HMM: 107-289/293.0
VEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYqYTGKMFINNRRADVSGDPKEYTIEVLPeGNSDSVICQvHHHAPWKHLQQPPKTLPIIK
|.||| |..... . . ..    .| |      . ...    . |.. ..    ..  |    ....   ...   . | .|.  |     | || ....
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek.ekeerkvrq.yhftsWpdhgvPektktlld

MIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
..... ...  . ... . |    | ||.  ||     ......    .|. |. .....|   | . .||  |.  | |....|.
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-188 2.8e-10 34.8 In-house 97-279 (281) alignment 
Range on Protein: 7-188
Range on HMM: 97-279/281.0
VEDFWYMIYQEQIHLVYLM---VPDDKLKntTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHApWKHLQQPPKTLPI
...|| |......... ..   .  .|||      . |.|   .| |.. ... ..  .    | ....  |..    . |... | |     | .|  .
lvafWqmvweqkvsaivmvtreieagklk..ChrYWPddnselky.gdvtvkstaeeekatyierkfkleresgetreveqlayta.WPdhGvPattkel

IKMIHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
..  .. |. ..  ..| ...    | ||. ..|.   .......   | ............|   | . .||. .| .| |.....
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_egg_pd Subfamily egg 7-209 1e-09 32.5 In-house 96-293 (307) alignment 
Range on Protein: 7-209
Range on HMM: 96-293/307.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPKeYTIEVLP-EGNSDSVICQVHHHAPWKHLQQPPKTLPII
|.||| |..||... . ..    . ..      . |.   ..  | . |.| . |   ||  ...  |   |  |      |    .... .    | ..
vddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadpl.frvtklklvGgddeerflehwqgdvnnssdvysplrvl

KMIHQflsekqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNG--IEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIsRKRGGKKAPVNKDIKR
... .           | | .  |. .|.... .  |. .|  |      . . .. ....|.  |||  .|  .| .|  .. |   |    .. | .|
rklrn.......lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff.rdvigsakeldvdyer

FINELTE
...| .|
wleerse
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 7-182 1.9e-09 31.8 In-house 88-263 (283) alignment 
Range on Protein: 7-182
Range on HMM: 88-263/283.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNR--RADVSGDPKEYTIEVLPEGNSDSVICqVHHHAPWKHLQQPPKTLPII
| ||| |...|.|  . .. .    ..   | .  ..|  .| |.. .  |   .  |   || .. |    .|  ...  .    | . .. .    ..
vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy.Geftvtlrkettsnsfiikelllrvnssakstllla.hyqvidWleygeqaiinslv

KMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
|.       .. ... . |    | ||.  ||.|  .....      .. ...|....||.. | .  ||  .. .|.
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl
0051429 (Phosphotyrosine protein) phosphatases II 7-186 4.3e-09 31.9 In-house 35-226 (272) alignment 
Range on Protein: 7-186
Range on HMM: 35-226/272.0
VEDFWYMiYQEQIHLVYLMVPDDKLKNTTTS-----------LFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GNSDSVICQVHHHAPWKHL
..|||.. ....|. .  . ... ..   ..            ..|.       |.... .    .  |   .....  . .....    . |.  |   
aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

QQPPKTlpIIKMIHQFLSekqvqNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPN--------ICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
  |...  ........|.     .  | |    |..|   .. .|. . ...     .        . |... ...|||| |.. .||. .| .. ... 
gvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_PTPN13_pd Subfamily PTPN13 7-183 6.4e-09 30.5 In-house 90-267 (273) alignment 
Range on Protein: 7-183
Range on HMM: 90-267/273.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLF--NDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPII
|.||| |... . ... ..  .   ..     .  . .|   . .... ... .     . .  ...|     ..|   .  . . |   . | ......
vkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaell

KMIHQFLSEKQvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
... .  . .. ... . |    | ||. ..|    ... ...  | .. ||......|| | | .  ||  .| .. .
qfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 7-188 2.2e-08 28.4 In-house 77-267 (270) alignment 
Range on Protein: 7-188
Range on HMM: 77-267/270.0
VEDFWYMIYQEQIHLVyLMVP--DDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDP--KEYTIEVLPEGNSDSVIcqVHHHAPWKHLQQP-----
...|| ||..|. . . .|.    .| ..     .  |..    . ...|. .    . .       ...  .|..  ..   ...  |     |     
lksfwrmiweekvtai.vmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreeds

-PKTLPIIKMIHQF-LSEKQVQNA-GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
  .|  ..||...   |||. ..|  . |    | ||.  .|   .|.. |..  . .. .|.......|.  |.   ||. .|. |  |..|.
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN3_pd Subfamily PTPN3 7-177 2.4e-08 28.2 In-house 97-267 (280) alignment 
Range on Protein: 7-177
Range on HMM: 97-267/280.0
VEDFWYMIYQEQIHLVYLMVP-DDKLKNTTTSLFNDENGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHApWKHLQQPPKTLPII
..|||.|.......|. ..    .. .      . ...   .|. .. .. .. | .       . .  .  . .  | |. . | |   . | ..  ..
atdfWqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla.WpdhgvPddsadfl

KMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASI
.....  . .....  | |    | ||.  .|    |.  ...  . .. .|......||   |.. .||  .
efvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv
0051082 (Phosphotyrosine protein) phosphatases II 7-179 4.5e-08 28.3 In-house 22-147 (151) alignment 
Range on Protein: 7-179
Range on HMM: 22-147/151.0
VEDFWYMIYQEQIHLVYLMVPDDKLKnTTTSLFNDENggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicQVHHHAPWKHLQQPPK---TLPI
 .||. ......|  .. . ...  . . ........                                          ..| |.   . |.    .  .
ladflellkelgiktivnlrseeerg.ycpeylpelg........................................ievlhipildwpdpglplsfdav

IKMIHQFLSekqVQNAGVCVVSLFGCGRACSFIGALYAINQlnngiePNICEIMKNIKQQRPGGVESFAQYASIYA
.......|.    .|  | |    |.||   .....  . .       .. |... ....||| | .. |.  .. 
leflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_PTPRN_pd Subfamily PTPRN 7-183 1.5e-06 22.2 In-house 113-290 (297) alignment 
Range on Protein: 7-183
Range on HMM: 113-290/297.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDP---KEYTIEVLPEgNSDSVICQVHhHAPWKHLQQPPKTLPI
| ||| |.... . ..  . . ..   . .. .  ..|   | .   ..     .  |    . . .  |   .    . | | .  |.. . |... ..
vadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfh.flswpeegvPasaksl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI-EPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
...  .     . . . . | .  |.||.  .|     .|.|..|. | .|.  .. ...|||| |.. .|.  ... | .
lefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN9_pd Subfamily PTPN9 7-188 2.1e-06 22.0 In-house 98-293 (297) alignment 
Range on Protein: 7-188
Range on HMM: 98-293/297.0
VEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIK
|.||| |......  . ..    .. .   .  ...|..  .  |.. ..|   ... | |. ..|.    ...|     .    |     |  .  ...
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslld

MIHQFLSE-------------KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
....  ..              ....  . |    | ||.  ||   .....|..    ...| .| ...||   .    ||.  |  | .|  ..
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 7-184 2.4e-06 21.4 In-house 107-282 (290) alignment 
Range on Protein: 7-184
Range on HMM: 107-282/290.0
VEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYQYTGKMFINNRRA-DVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPII
| |.| |. ||..  . ..    .. |      . ...|     |.. .      |   . .  |. |    .  . . . ..   |     .  || ..
vidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

KMIHQFlsekQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
....      .  .  | |    | ||. .|.    ... | .| | .. .... ... | . |.   ||  .  |..|.
rtlril....rkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-186 5.9e-06 20.2 In-house 98-294 (301) alignment 
Range on Protein: 7-186
Range on HMM: 98-294/301.0
VEDFWYMIYQEQI-HLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEV--LPEGNSDSVICQVHHH---APWKHLQ-----
. ||| .|.||.  ..| ..  ... |. ..  ... .   .. |.. .      |  |     . |      |  ... ... .   ..|. ||     
lvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtd

-------QPPKTlpIIKMIHQFLSEKQVQNAGVCVVS-LFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
       . |.|  ... |.. .  .|  . |  ||    . .|.  ..    .. |       .. .. | .....|| |    || ||| ..  |..
WpqdGvvreprt..vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 8-186 2.4e-12 41.1 In-house 97-280 (303) alignment 
Range on Protein: 8-186
Range on HMM: 97-280/303.0
EDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPK-TLPIIK
 ||| || ..... | |.. | . ..        .|  .    . .|           . ... ||   | |   . .|||.  | | . | . .  ..|
adfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvk

MIHQFLSE--KQVQNAGVCVVSLFGCGRACSFigALYAINQLNNGIEPNICEIMKNIKQQRPG---GVESFAQYASIYAIVFDYIS
 | |  |   |  ..     .|| ||||| .|  ||.   .|    | .  ...| ... | |    |. ..|.. .|... ... 
qiwqlqsvlrkysdstptvymslsgcgragtf..alfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
0044763 (Phosphotyrosine protein) phosphatases II 8-179 5.6e-09 31.4 In-house 38-165 (178) alignment 
Range on Protein: 8-179
Range on HMM: 38-165/178.0
EDFWYMIYQEQIHLVYLMVPDDKLK--NTTTSLFNDENggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicQVHHHAPWKHLQQPPkTLPIIK
.|.. ..... |...  . ... |   ..    . ...                                          ..| |.     |.  | .. 
addlellkelgithivnlteelelgflkcdpywpeeag........................................iqylhipipDhgvpd.llehfl

MIHQFLSEKQ-VQNAGVCVVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPgGVESFAQYASIYA
 ...|. | .  ..  | |    | ||..... | . . .       .. |... ....|| .|... |.  .| 
efvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLye
0036282 (Phosphotyrosine protein) phosphatases II 10-178 1.2e-10 36.8 In-house 28-163 (174) alignment 
Range on Protein: 10-178
Range on HMM: 28-163/174.0
FWYMIYQEQIHLVYLMVPDDKLKNTTT-----SlfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQVHHHAPWKHLQQPP--KTLP
||.|.....|. |  . .   |...       .                                       .. .     ... ||   . |.  . | 
fwemlkelgittvvmlleekelglykcinywpe.....................................lredlerlgiqylylpwpDhgvpdlsille

IIKMIHQFLSEkqVQNAGVCVVSLFGCGRACSFIGALYAINQLNngiePN---ICEIMKNIKQQRPGGVESFAQYASIY
..| ....|||   ..  | |    |.||.  ...|.. . .|     ..   ...... ...||||.|... ||  .|
fvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 36-175 4.8e-07 23.6 In-house 178-330 (347) alignment 
Range on Protein: 36-175
Range on HMM: 178-330/347.0
TSLFNDENGGYQYTGKMFINNRRADVSGDPK----EYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTLPIIKMIHQFLSEK----QVQNAGVCVV
.|.|  |   |      .|| |. .|    |     ||.||. || |.. ...|.  . |   . |    | | ...   .  |        . | | |.
ssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvm

SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVE--SFAQYA
  .|  |... . .   |.|. .|  |.  ...|....|| |      |  ||
cdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytya
0049772 (Phosphotyrosine protein) phosphatases II 58-189 1.4e-11 40.2 In-house 167-284 (314) alignment 
Range on Protein: 58-189
Range on HMM: 167-284/314.0
RadvsgdpkeytiEVLPEGNSDSVICQVHHHAPWKHlQQPPkTLPIIKMIHQFLSEKqVQNAGVCVVSLFGCGRACSFIGALYAINQLnnGIepNICEIM
.            |.| ...  .     ... |.    ..| .| ... . .|. |   ..  | |    |.||...|. | | . .|  |.  .. |..
k............eelydpelferlgikylripvpD.gsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleeal

KNIKQQRP-----GGVESFAQYASIYAIVFDYISRKR
. ....||     | .|.. ||  |. .. .|.....
edvrlkRpinpnpgfieqleqyefilealleylkflk
0048179 (Phosphotyrosine protein) phosphatases II 70-178 3.7e-09 32.0 In-house 34-138 (144) alignment 
Range on Protein: 70-178
Range on HMM: 34-138/144.0
IEVLPEGNSDSVICQ--VHHHAPWKHLQQPPKTLPIIKmIHQFLSEK-QvQNAGVCVVSLFGCGRACSFIGALYAInqlNNGiePNICEIMKNIKQQRPG
| . .|   ......   ..| ||   . |. .  ... . .|. |  . ..  | |    |.||..... |   .    .|   .. |... ....|||
inlteeyepefleregiqylhlpwpDhgvpdllellle.flefieeale.eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpg

GVESFAQYASIY
.|... |.  ..
avpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 75-181 4.8e-09 31.5 In-house 39-139 (145) alignment 
Range on Protein: 75-181
Range on HMM: 39-139/145.0
EGNSDSVICQVHHHAPWKHLQQPPKTlPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnngIEPNICEIMKNIKQQRPGGVESFAQY
| .  .     ... ||   . |. .  ..  . .|. | . ..  | |    |.||......|   .         .. |... ...||||.|... |.
elellerlgiqylylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgql

ASIYAIV
  .|  .
rflyefe
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 75-189 9.4e-07 22.8 In-house 179-291 (305) alignment 
Range on Protein: 75-189
Range on HMM: 179-291/305.0
EGNSDSVICQ-VHHHAPWKHLQQPPKTLPIIKMihqfLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP-NICEIMKNIKQQRPGGVESFA
||   ..     .|   |     |.  | |...    | . ..    . |    | ||. | .   | ..|| .|    .   |.. |..||   ... |
egpgekarkvthyhwidwpdrgvpaadlailel....lekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtda

QYASIYAIVFDYISRKR
||  .. ....|. .|.
qylfvhqvilnyfrkkk
PTPc_DSPc_SM00012 84-181 5.3e-20 67.0 In-house 3-103 (105) alignment 
Range on Protein: 84-181
Range on HMM: 3-103/105.0
QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQ--NAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQYASIYAI
.. |.  |.. . | .. .|....... ..|. .  .. |.|..  |.||.. |. . ....||...  |..|..|.| ...|||| |....||  .|..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

V
.
l
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 95-185 8.2e-07 23.3 In-house 167-259 (267) alignment 
Range on Protein: 95-185
Range on HMM: 167-259/267.0
QQPPKTLPIIKMIHQFLSEKQVQNAGVCVV--SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.   .  | .| .   |...|..|..  .|     | ||. .|. .   .... .    .| . ...|..||.| |..  .|  |. .. .| 
nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_DSP23_pd Subfamily DSP23 98-179 8.2e-06 20.5 In-house 64-140 (148) alignment 
Range on Protein: 98-179
Range on HMM: 64-140/148.0
PKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIgALYAINQLNNGiepnICEIMKNIKQQRPGGVESFAQYASIYA
| .|  .. . . . | . .|  | |  | | ||. ... | | . . .       .| . .....||| ||.. |   .. 
ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtml.acylvkerkla....aaeaiaevrrlrpgsvetveqeklvrd