Synonym: CELE_ZK809.1, ZK809.1
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 110-399 | 2.6e-115 | 379.0 | In-house | 3-295 (302) | alignment | ||
Range on Protein: 110-399
Range on HMM: 3-295/302.0
KKKEKEKWSGEDASIKFKELrFNQSEggVRRDTeASCPN------RCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLP
...|||||..|....|. . ....| |.... .. . .||........|...|....|.|........|.|.|.||..||..|.||.|.|||
veeekekWveeeeakklvks.ldtae..vkkef.kkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlp
KMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKaDMFVVELLPEGCSNAVMCSVYLHTYWKPLFG
|.||.|.||||||.||.|....|.|....|||.. ....||...||...... .|||.|||||.|..| ...|.|.|||||||.|...||..|.||. ..
kvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkv
PDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL--PSGH
|......|..|... ||.......|||.|.||.||..|.|||||. ..|..||||.|.|||..||.|||..|||..||||||.|....||.|. |...
pvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeek
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 113-394 | 1.7e-12 | 41.9 | In-house | 19-300 (306) | alignment | ||
Range on Protein: 113-394
Range on HMM: 19-300/306.0
EKEKWSGEDASIKFKELRFNQSEGGVRRDTEAScpnrckmwQSHSSRNRHTDYKCYDHNRIIV---QMCKDDYINGSKINVPHFTP-SIYLVQLPKMdsV
|.|. . .. . .|.||. .... . |. | .. ..||. .||.|.|. .. .||||.. |. . |. .
eeeslekagfeeefeelqqeeakkllsrkegak........penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl..e
DAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKvEKKENAKADMFVVE-LLPEGCSNAVMcsVYLHTYWKPLFGPDRF
. |..|||.|. |... . .. . | .. . . .|. | . |... ..... . ..|. .... |. | .. | |
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevf..qyhfksWPdhgvpkdp
GAQIRAAHQIAKNEN-----GNSPTVIASVNGSGRNAALLTLAVVEDQLTRG---KEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTK
|| . ... .... . |.|. .| || ... . .. ..... . | ..|...|||| . | || .|.| . |.||
gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 123-397 | 3.5e-21 | 70.3 | In-house | 11-283 (290) | alignment | ||
Range on Protein: 123-397
Range on HMM: 11-283/290.0
SIKFKELRFNQSeggvRRDTEASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVV
. .|..|. .. . .|. ... . ... .||. | ||..|. .. . .||||.. |. .. . . | | .....|||..
akefqklkklse....kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLp...ktlddfWrmi
FHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTrkvEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA
.. . . | .. | || .. . .| . | . | |.. |.... . |... | | .. . . .| | | .. .. ...
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtl...eeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvr
K-NENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEP---KISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPS
. .|. ..| |. | || ..... | ..| ..| | .. ..|...|.||. | . ||. .|.| |....| .
elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 124-393 | 2.5e-43 | 144.4 | In-house | 23-306 (307) | alignment | ||
Range on Protein: 124-393
Range on HMM: 23-306/307.0
IKFKELRFNQSEGGVRRDTEASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK-----DDYINGSKI--------NVPHFTPSIYLVQLPKMDsvdA
..|... . . | .. .. ... .. ... . ..||..|. .|||.|.... .. .||||.| . ...... . . | |. .
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...t
VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWLYANGFFVNTRKVEKKENAKADMFVVELLpEGCSNAVMCSVYLHTYWKPLFGPDRFGAQ
||.||| ......... . ...||... ... . .| | .|. . |.|.....|.... . . |. | .|... .. .. .| | |. |
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeel
IRAAHQIAK--NEN-GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKE---PKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
.. ... | .|. ...|... . | || ...... .. .|| .... . . |.|...|||||..| .. ||. ||.| .|...
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 138-415 | 2.9e-17 | 57.7 | In-house | 29-306 (318) | alignment | ||
Range on Protein: 138-415
Range on HMM: 29-306/318.0
VRRDTEASCPNRCkMWQSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPE
. |..| . . . . .||... ||| |. .|| .. |||| . |. . . . | | ...|.|||.|. ..... .... |
lsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlp...etieDfWrmvWeqnsavivmltqee
ELTNPAIDKLFCQeSGAWLYANgFFVNTRKVEKKENAKADMFVVELlpEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE--NGNSPTVIAS
| . ... . . .|. | . |. .. . .. | |. ..... . | .| | |. . . |. | . .|..|.|.
ergkakvhryWPs.kgsrsygk.lvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC
VNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLP--SGHEVVSKIKKFNEKATRS
| || ... .. ... . . ..|...||||. | ||. .| . ... . . ... |.|....|. . |
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpes
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 140-395 | 3.5e-46 | 153.3 | In-house | 52-303 (308) | alignment | ||
Range on Protein: 140-395
Range on HMM: 52-303/308.0
RDTEASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQmCKDDYINGSKINVP--HFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTN
... ... .. ... . ..||..|. .|||.|.... ..|||| | .... ... . . | |. . || ||| |........ . ...|
lsvkplleysvallpenkdkNrykdilpydhsRVkld.egsdYInAsyvdgyssklprkfIatqgPl...pntvedFwrmvweqnvrvIvmLtklvengr
PAIDKLFCQESG-AWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEnGNSPTVIASVNGSG
. .. . | | .|. ..|.|.....|. .. ....|| . |... .. .. .| |. |. . . .. ... | ...|.|. . .| |
ekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvG
RNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
| .....| .. .|| ..... . |.|...|||||..| .. ||. ||.| ...|.||
RtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 143-396 | 1.1e-50 | 168.0 | In-house | 26-282 (297) | alignment | ||
Range on Protein: 143-396
Range on HMM: 26-282/297.0
EASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDK
.... .. ... . ..||..|. .|||.|.... ..||||.| ....... . . | |. . ||.||| |........ . ...|| . ..
lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmltelvelgrekcaq
LFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKpLFG----PDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRN
. | | .|. ..|.|....||..... ....|... |... .. .. .| | .| |. . . |...... |. ....|... ...| ||
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs
AALLTLAVVEDQLT---RGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLP
...... .. .|| . ... | |.|...|||||..| .. ||. ||.| .|.|.||.
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 144-391 | 2.3e-45 | 150.6 | In-house | 26-272 (273) | alignment | ||
Range on Protein: 144-391
Range on HMM: 26-272/273.0
ASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKL
... .. ... . ..||..|. .|||.|..... ..|||| | ........ . . | |. . ||.||| |........ . ...|| .. ..
plltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvrviVmLtelvelgrekcaqY
FCQESGA-WLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGP---DRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNA
. .| | .|. . |.|.....|. .. ....|| . |... .. ....| | | . . |...... .. ..|.|.|. ...| || .
wpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg
ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
....| .. ||| ..... . |.|. .|.||| .| .. ||. ||.| ...
tfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 145-395 | 4.5e-44 | 146.5 | In-house | 45-293 (297) | alignment | ||
Range on Protein: 145-395
Range on HMM: 45-293/297.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD-----DYINGSKINVPHF-TPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNp
.. .. ... . ..||..|. .|||.|........ |||| | ...... |. ... | | . || ||| |........ . ...|| .
kpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe...tvedFwrmvweqgvtvivmLtklvelgr.
AIDKLFCQESGawlYANGFFVNTRKVEKKENAKADMFVVELlpEGCSnaVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN---GNSPTVIASVNGS
.. . .|.| . ..|.|...|||.... . . |. .|.| .. ....| | |. . ... ... . . .. |... ...|
kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGv
GRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
|| ...... . .|| ..... . |.|...|||||..| . ||. ||.| .|.|.||
gRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 145-391 | 2e-43 | 144.2 | In-house | 34-277 (278) | alignment | ||
Range on Protein: 145-391
Range on HMM: 34-277/278.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
.. .. ... . ..||..|. .|||.|....... .|||| | ........ ... | | . || ||| |......|. . ...|| ..
ldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...tvedFwrmvwelgvttivmLtelvelgrvkc
DKLFCqesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNA
.. . | .|. ..|.|...|.|. .. ... |. . |... .. .| .. | |. . .. ... . . |.|... ...| || .
aqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTG
ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
....| .. .|| ..... . |.|...|||||..| . ||. ||.| ...
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
DSPc_SM00195 | 145-389 | 5.6e-43 | 142.5 | In-house | 16-260 (263) | alignment | |||
Range on Protein: 145-389
Range on HMM: 16-260/263.0
ScPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
. . ... ... .|.||......|||.|.... . .|||| . |.... . .. . | |. . ||.|||.|..|..... .. ..|| . .
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekc
DKLFCQESGAWLYANGFFVNTRKVEKKEnAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG-NSPTVIASVNGSGRNA
|. . .||| . . |....||||. .. . ..|| ||.... . .| .. |. || .. ... | .. ..|.|. . .| || .
drywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtg
ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNW
...|. .. ..|...|...|.|||. .|.|||..|.. || .|.|
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
|
|||||||||
PTPc_SM00194 | 145-389 | 5.6e-43 | 142.5 | In-house | 16-260 (263) | alignment | |||
Range on Protein: 145-389
Range on HMM: 16-260/263.0
ScPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
. . ... ... .|.||......|||.|.... . .|||| . |.... . .. . | |. . ||.|||.|..|..... .. ..|| . .
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekc
DKLFCQESGAWLYANGFFVNTRKVEKKEnAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG-NSPTVIASVNGSGRNA
|. . .||| . . |....||||. .. . ..|| ||.... . .| .. |. || .. ... | .. ..|.|. . .| || .
drywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtg
ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNW
...|. .. ..|...|...|.|||. .|.|||..|.. || .|.|
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 145-395 | 9.1e-43 | 142.0 | In-house | 17-278 (284) | alignment | ||
Range on Protein: 145-395
Range on HMM: 17-278/284.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQM-----CKDDYINGSKINVP-----HFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEE
... .. ... . |.||..|. .|||.|..... .|||| | .... .... . . | |. . ||.|||.|........ . ...|
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelve
LTNPAIDKLFCQEsGAWLYANGFFVNTRKVEKKENAKADMFVVELLpeG-CSNAVMCSVYLHTYWKPLFGP---DRFGAQIRAAHQIAKNENGNSPTVIA
. .. . .| | .|. ..|.|.....|.|.. . .. .. | | ... ... .. .| | | . . . .|..... .| .|..|.|.
ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVH
SVNGSGRNAALLTLAVVEDQLTRGK---EPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
. .| || .....| .. .|| ... .. . |.|. .|||||..| .. ||. .|.| ...|.||
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 145-391 | 6e-42 | 139.4 | In-house | 38-286 (288) | alignment | ||
Range on Protein: 145-391
Range on HMM: 38-286/288.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
... .. ... . ..||..|. .|||.|..... .|||| | |...... . | |. . ||.||| |........ .. ...|| .
dltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn...tvedFWrmvweqnvrvIvmltklvelgrekc
DKLFCQesGAWLYANGFFVNTRKVEKKENAKADMFVVELL--PEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN-ENGNSPTVIASVNGSGR
.. . . | .|. . ..|.....|.... . . |. | ..|... .. .. .| | || . . .. ... | ..|..|.|. . .| ||
aqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgR
NAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
.....| .. .|| ..... . |.|...|||||..| . ||. .|.| ...
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 146-384 | 2.4e-10 | 34.8 | In-house | 23-259 (283) | alignment | ||
Range on Protein: 146-384
Range on HMM: 23-259/283.0
CPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHF--TPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKL
. ... . . ||. . .| .|. .. |||| . | | . |.. .| ..| .||..||.|. .. .... | . . .
ldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld..rtvvdfWkmvfdekitaivmltklqedlrikCsqy
FCQEsGAWLYANgFFVNTRKVEKKENAKADMFVVELlPEGCSNAVMCSVYLHTYWkPLFGPDRFGAQIRAAHQIA--KNENGNSPTVIASVNGSGRNAAL
. .. |. | . | | || .. ... . .... . | | .|.. . .. ..|. ..| |. .| || |..
WPkr.GsedyGe.ftvtlrkettsnsfiikelllrv.nssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf
LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
..... ... . ..|. .||||. | . || ..
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 147-397 | 1.4e-46 | 154.6 | In-house | 34-282 (317) | alignment | ||
Range on Protein: 147-397
Range on HMM: 34-282/317.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDK
. .. ... . ..||..|. .|||.|.... .. .|||| | ...|.... . . | |. . || ||| |........ . ..||| .. ..
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...pntvedFwrmvweqgvtvivmLteleelgrekcaq
LFCQesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN-ENGNSPTVIASVNGSGRNAAL
. . | .|. ..|.|.....|. .| ....|. . |.|. ... .. .| | |. . .. ... .. |....|... ...| || ...
Ywpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtf
LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPS
... .. .|| ..... . |.|...|||||..| .. ||. ||.| ....|.||..
iaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 147-392 | 6e-39 | 129.5 | In-house | 2-247 (249) | alignment | ||
Range on Protein: 147-392
Range on HMM: 2-247/249.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDK
. .. ... . ..||..|. .|||.|.... ... |||| | |....... . . | | . .|| ||| ......... . ...|| . ..
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe...tvedfwrmlwelgitvivmLtslvelgrekcaq
LFCQesGAWLYANGFFVNTRKVEKKENakADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN---GNSPTVIASVNGSGRNA
. . | .|. ..|.|....||.|.. ....|| . .... ... .. .| | |. | .. ... | . ..|... . .| || .
ywpl..ggsleygdftvtllsvevkdd..ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG
ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
..... . .|| . .. . |.|...|.|||..| .. ||. ||.| .|..
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 147-364 | 2.4e-13 | 44.5 | In-house | 23-244 (290) | alignment | ||
Range on Protein: 147-364
Range on HMM: 23-244/290.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQ
| | .. ..||. | . ||| ||... . |||| | ..... | | | | . .|. ||..|.......| .. . | . . . |
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpn...tvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq
ESG-AWLYA--NGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAK---NENGNSPTVIASVNGSGRNAA
. | . |. . |.|.. . .. .| | . .. . .| | . |. .| .. ... . . |.|| | || .
geeekellledtklkvkliseerksyytvrllelenlktqetreil..hfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt
LLTLAVVEDQLTRGKEPKI---SEIVR
. . . .. . .. . .. .
fclvdtclvliekkddlssvdikkvll
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 147-243 | 2.8e-06 | 21.2 | In-house | 31-130 (301) | alignment | ||
Range on Protein: 147-243
Range on HMM: 31-130/301.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIV------QMCKDDYINGSKINVPHFTPSIYLVQLPkMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
.. .. .... ||. . . ||.||||. ..|. .||| | |. . | | |. . .|||....|. ... ... .| |.
sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgp.mk..ktlvdfWrliwqekpvsivmvtnlkegtkskc
DKL
.
eqy
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 149-391 | 3.4e-34 | 113.9 | In-house | 3-242 (243) | alignment | ||
Range on Protein: 149-391
Range on HMM: 3-242/243.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMckDDYINGSKINVPhftPSIYLVQLPKMDSVDA-VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqe
.. ... . |.||..|. .|||.|.... .||||.. |.|. | ... |.| ..|. ...||| ......... . ...||. ....
siallpenlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..
sGAWlYANGFFVNTRKVEKKENAKADMFVVELLP-EGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAK---------NENGNSPTVIASVNGSGR
| . . ..|.|.. ..| ... . ....| |. .... |. |... | || . .. ... . ......|... . | ||
.gev.tygdftvtllseehlddytvrtlllenldlddltrlvi..hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR
NAALLTLAVVEDQLtrgkEPKISEIVRTIREQRPQ-SVDSYIQYVSLYMATNWLI
..|... .. ..| . . |.|...|||||. .| .. ||. ||.| .|.
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 149-386 | 4.1e-24 | 79.9 | In-house | 36-275 (288) | alignment | ||
Range on Protein: 149-386
Range on HMM: 36-275/288.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKI-NVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQE
. . . .|..||..| |||||. .. |||||| | . .. .|.. | |. . . .||..|.... ... .. .||| .| .|. . ..
siaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst...lnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed
SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVmCSVyLHTYWKPLFGPD---RFGAQIRAAHQ--IAKNENGNSPTVIASVNGSGRNAALL
|. . . | ..|.. |. .. .| |.. . | . . | | | |. . . . .... |.... . | |. |.|| ..
kgetvkfgdlsvtlksvretethvervlkletldadavksv.shl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa
-TLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|.|.. .. . | ..|...|||| .| |. .| |
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 149-392 | 1.9e-17 | 58.4 | In-house | 28-270 (273) | alignment | ||
Range on Protein: 149-392
Range on HMM: 28-270/273.0
RCKMWQS--HSSRNRHTDYKCYDHNRIIVQMCKDdYINGSKINVPHfTPSIYLVQLPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQ
.|.. .. . ..||. . ||. |.... ||| | |.|| | . . ..|..||..|. ... . ... | . .. . .
tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe
ESGAWLYANG-FFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYlhTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLA
. . | ... . |. ||.|... . . |. . | |. |. . . | | .. . .... .. ..| |. | || .|.|.
sknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf..vkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitid
VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
|| . . | || ...||||..|||| | . ||. | |. ..|
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 149-385 | 4.5e-17 | 56.6 | In-house | 35-284 (296) | alignment | ||
Range on Protein: 149-385
Range on HMM: 35-284/296.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVpHFTPSIYLV-QLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKL
.. . . .||. . ||.||.... |.|||| . .. . . |.| . || . .|.||||.|. |....| ..... . .. .
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvds.flkkkeyivteapkke...tvdefWrlvydeeisavvvLtktfdfak.mypsy
FCQESgAWLYANgFFVNTRKVEKKENAKADMFVVELL--------PEGCSNAVMCSVYLHTYWKP-LFGPD---RFGAQIRAAHQIAKNE---NGNSPTV
. ..| | . .||.. .... | | .| . . . .. .. | |. | . .| .... .. . ..|.|
wpnks.keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv
IASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
. | .|..| . |.. . ... . .| . | |.|.|..||| |.. .| .|
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 149-386 | 1.2e-13 | 45.8 | In-house | 42-291 (300) | alignment | ||
Range on Protein: 149-386
Range on HMM: 42-291/300.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD---DYINGSKINVPHFTPS-IYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLF
. . ..||. | |..||. .. .|. .||| |.|.|. . . |.| . .|..||..|. .. | . .... || . | |
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl..eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf
CQE--SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYlhTYWKPLFGPD------RFGAQIRA----AHQIAKNENGNSPTVIASV
.. . . . | | |. .|. . . . .. || . |. | | | |. . .... ... .... . | ..
Pkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs
NGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.| || |.. .. | ..| .| ......|||| |.. || .| .
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkv
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 150-391 | 3.9e-37 | 123.4 | In-house | 3-243 (245) | alignment | ||
Range on Protein: 150-391
Range on HMM: 3-243/245.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFC
. ... . ..|| .|. .|||.|.... . .|||| | ......|| ... | | . || ||| .......|. . ..||| . .. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqywp
QesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN--GNSPTVIASVNGSGRNAALLT
. | |. ..|.|.....|. ... ....|. ..|.. .. .|... | || ... . . | . .| |... . | || .....
l..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia
LAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
. . .|| . .. . |.|. .|.|||..| . ||. ||.| .|.
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 150-393 | 4.8e-26 | 87.2 | In-house | 27-274 (278) | alignment | ||
Range on Protein: 150-393
Range on HMM: 27-274/278.0
CKMWQSHSSRNRHTDYKCYDHNRIIvqmckdDYINGSKINVPhfTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqEsG
. .. .. ..|| .|. .|||.|.. |||| | |... .. . | |. . |. ||| ......... ... .||.. .. . | |
palylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlp...stvadfwrmlwelgitvivmltelvelgrekcaqywp.e.g
AWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTY-WKPLFGPDRFG---AQIRAAHQIAKNEN--------------GNSPTVIAS
.|. ..|.|.. ..| .. .. |. | .. |. . | . | .|. . ... .| . . .. |...
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC
VNGSGRNAALLTLAVVEDQLtrGKEPKISEIVRTIREQRPQ-SVDSYIQYVSLYMATNWLIKT
| || ..| . . ..| .. . |.|...|.|||. .| . ||. ||.. .|..
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 150-383 | 9.7e-17 | 55.8 | In-house | 27-251 (267) | alignment | ||
Range on Protein: 150-383
Range on HMM: 27-251/267.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVpHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARpeeLTNPAIDKLFCQESG
. . . ||| | ||..|.|.. ...||| | .. . | ..| .. .. .|. |. .... .. .. . | ... . |
qsiaeknqernrlddnlpyddtrvilrtkeeeyinasyveg.yktknafivtqdplk..ntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmg
AWLYANGFFVNtRKVEKKENAkADMFVVELLPEGCSnAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTlavVED
. . |. . .||.|| .. ..|| . | | ..| . |. . . . . |||| | |.| .| || ..|. ..
qakkyqdltve.hslekeend.yqiitlelkfknes.ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflv...ids
QLTRGKEPKISEI---VRTIREQRPQSVDSYIQYVSL
|| | |. .|.| .| ||.||. ||. .|. .
qleraktegvsdifdflrkirsqriglvdtkeryiyi
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 150-392 | 2.2e-13 | 44.9 | In-house | 37-273 (288) | alignment | ||
Range on Protein: 150-392
Range on HMM: 37-273/288.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESG
. . . ..|.|... . | |. .. | ||. . .. . | | ..||.|....... . . .... |. .. .. | . |
idsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG
AWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTyWKPLFGPDRFGAQIRAAHQIaknENGNSPTVIASVNGSGRNAALLTLAVVED
. . ..| . . . .. || . .. ..|. |. |. . . .| . . .. . | |. | .|.|| ..| .. .
ekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlle.WdddgvPenylsplrllevl...kslqkPivvhssaGvGrtgtlililiale
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY-MATNWLIK
.| | ... ||.| ... . ||. .. . . |.
slrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 150-386 | 7.2e-13 | 43.2 | In-house | 36-285 (297) | alignment | ||
Range on Protein: 150-386
Range on HMM: 36-285/297.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFC
. . .. ...||.|| |||. |. .. .. |||| . .. . .. | | .|..|||.|. ... .. ...| .| . .
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk...tvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp
QESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCsvYLHTYWkPLFGPDRFG-------AQIRA-----AHQIAKNENG---NSPTVIA
.|... . |.. .||..|. | ..... .. | |. . . | | .| . . ..| .........| . | |.
leeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth..fqflsW.PdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh
SVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
| || .. || . ..| . .. | |...|.|| |. ||. |.|
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 150-384 | 3.3e-10 | 34.3 | In-house | 40-276 (290) | alignment | ||
Range on Protein: 150-384
Range on HMM: 40-276/290.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQ------MCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKL
.. .| . .|| ... || |||... |...||| . |. . . ...| | .. . .||... .|.. . .. | . .
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn...tlvdFWkliwqekvtiivmltniieegkvkCqqY
FCQESGAWlyANGFFVNTRKVEKKENAKADMFVVELLPEGcSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK--NENGNSPTVIASVNGSGRNAAL
. ... . . | .. . |. .. . |. .. .. . | | |.. . . . ... | .|| . |. .. || | .
Wpdsdtka..ygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavf
LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
...|. .. . ..... | |.|.|| . || ..
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 151-384 | 9.7e-14 | 46.1 | In-house | 36-270 (307) | alignment | ||
Range on Protein: 151-384
Range on HMM: 36-270/307.0
KMWQSHSSRNRHTDYKCYDHNRIIVQM--CKDDYINGSKINVPHFTPSIYLVQLPKmDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
. ... . .||..| || |..||.|.. ||| . . . | |. .. .. .|| .. |. ..| .... ||.. .. . |
eafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgpl.en..tqysfwamaiqekvesvimlckvielakikceqywplee
GAWL-YA-NGFFVNTRKVEKKENAKADMFVvELLPEGCSNAVMCSVYLHTYWKPLfgPDRFGAQI--RAAHQIAKNENGNSPTVIASVNGSGRNAALLTL
| | .. .. .. .. |. | . .. .. | . | |. ||| || | . . . | |. | || .....
gqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenw..pdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivai
AVVEDQLTRGKEPK-ISEIVRTIREQRPQSVDSYIQYVSLY
..| |.. .|.. | . ..|. .|.||. .. . .||. |.
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 153-392 | 9.9e-15 | 49.3 | In-house | 48-286 (293) | alignment | ||
Range on Protein: 153-392
Range on HMM: 48-286/293.0
WQSHSSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
. ...||.|. |||.|. .. ..|||| . |. . . | | .. |..|||.|. ...... .. . | .. . ...
lavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet...vddfWrmvwekkssiivmltqlvekgkvkCeeYWPade
GAWLYANgFFVNTRKVEKKENAKADMFVVELlpegCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA---KNENGNSPTVIASVNGSGRNAALLTLA
. || . |. . |..|. . .| .. | .| | |.. . .. ... .... ..|.|. | || ....|
epvlyGd.ikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald
VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
. ..... | || .||.| . | . ||. .. . |..
rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 153-393 | 4e-13 | 44.2 | In-house | 43-285 (305) | alignment | ||
Range on Protein: 153-393
Range on HMM: 43-285/305.0
WQSHSSRNRHTDYKCYDHNRIIVQMC--KD--DYINGSKINVPHFTPSIYLVQLPkMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
. . ..||... .|..|||.. .| |||| | .. . . . | | .. . |..|||....|. .|. .... | . . . ..
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgP.lk..ntvadfWrliveekvstivmltklveggkdkCrqYWpesk
GAWLYANGFFVNTRKVEKKENAKADMFVVELlPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN--SPTVIASVNGSGRNAALLTLAV
. . | |. . .. .. . . .. .. . | | | |. .. .. ... |. . . | .. .| || . ... .
tekkefgefsvelksektasdyieRklkisi.ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdi
VEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
..| . .. . |.....|..|.. | . |||.|. | . ||..
alerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 153-386 | 1.4e-12 | 42.2 | In-house | 32-265 (285) | alignment | ||
Range on Protein: 153-386
Range on HMM: 32-265/285.0
WQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAwL
... ||..| .| . |.... ||| | . .| | |. . ... .||.....|. | ... | . .. | .
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl..petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge.v
YANGFFVNTrKVEKKENAKADMFVVELLPEGCSNAVMCSVYLH----TYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVE
| . | | ||.| | . | .| .|. .| . |. | . . | . . | .. | || |... .
vkfgkyeit.lteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat
DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.. . .. .||| .| | |.|.|..|.. ||.
irimenpniemldivremramrfqavqshmqflflyvv
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 154-390 | 7.2e-18 | 59.7 | In-house | 46-282 (319) | alignment | ||
Range on Protein: 154-390
Range on HMM: 46-282/319.0
QSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESg
. ...||... . ||. |.... .. |||| | |. . | |. . ..|.|||.|..|.. .| .... | . . |.. .|
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen...tiedfWrmvWeeessivvmltklveklkvklkkywpeen.
AWLYaNGFFVNTRKVEKKenakADMFVVELLPEGCSNAV---MCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG--NSPTVIASVNGSGRNAALLTL
. | . |. . |.. .|. . .| . |. | . . . .| | |.. . . ..|.| .. . | |. .|.|| . ..|
feey.Grlivtleeeeel....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl
AVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWL
.. ... . . ..|...| ||. |. || .| |
damlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 154-387 | 2.2e-15 | 51.3 | In-house | 42-273 (315) | alignment | ||
Range on Protein: 154-387
Range on HMM: 42-273/315.0
QSHSSRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEEltNpaiDKLFCQESG
. ..||. . .|..|... . ..|||| |.|. . . | |. ||| .|||.|..|. |. ... .| . ||. |.
tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd...dfwrmvlqekvttivmvtkkqe..g...dkikcrqyw
AWLYANGFFVNTRKVEKKE-NAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVV
|. . ||| . .| .|. . .| . . . | | . . .. .. ... |.. . . .. . | || .... |
PdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev
EDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
.|. |.. . ..|...|..||. | . .| .| |
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 154-385 | 3.2e-14 | 47.6 | In-house | 45-272 (287) | alignment | ||
Range on Protein: 154-385
Range on HMM: 45-272/287.0
QSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGawLY
.. .|| |. .| .|.... ...|||| . |. . . . | .... .||... ... ... .... .| .. . . . .|. ..
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPm...fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vv
ANGFFVNTRKVEKKENAKADMFVVELLPEgCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE--NGNSPTVIASVNGSGRNAALLTLAVVEDQL
. .. . |.... . |. . .. . | | |. .. . . .. |.. .||.. |. .. || | .. |. ..
lGeyniellneevnagyierklevknknk.agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc
TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
. . .... | |.|.|| || ..
kteGviDvfqvlksqriqkpgsvqtveqykfind
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 154-387 | 2.8e-13 | 44.1 | In-house | 45-275 (439) | alignment | ||
Range on Protein: 154-387
Range on HMM: 45-275/439.0
QSH-SSRNRHTDYKCYDHNRIIVQ----MCKDDYINGSKINVpHFTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCqtVHIIArpeeLTNPAIDKLFCQE
|.. ..||. | .|| |...| . . ||| |. .... .|. | || .....|||.|..... |.|. ||| .
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkk...ettddfwrlviekkt..vtivm....ltnlvesykywps
SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSvYLHTYWKPLFGPDR--FGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLA
.. | . |..| . . . |.. . . . . .. | | . . . | . |.... | |. | || ....|
daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlq.fhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiiald
VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
. .|| .. | ||. .|.|| | |.. ||| .| |
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 154-395 | 4.9e-12 | 40.2 | In-house | 47-292 (305) | alignment | ||
Range on Protein: 154-395
Range on HMM: 47-292/305.0
QSHsSRNRHTDYKCYDHNRIIVQM-CKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNP-AIDKLFCQESGAW
| . .||. | | |.||. .. .|| . | . . | | . . .|| . . .. ... .. | .. . ...
qea.gknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplek...tcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl
LYANG------FFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHtyWKPLfgPDR--FGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLT
. .. | . ... ...|||.. .|. || . . | | ||| |.. ..| |.|. | || ...
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyh..widw..pdrgvpaadlailellekarpskgpivvhcsagigrtgsvvm
LAVVEDQLTRGKEPK-ISEIVRTIREQRPQSVDSYIQYVSLYM-ATNWLIKTKL
| . ||| |. . |.. ||||| .|... ||. .. |.. | ||
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 154-386 | 5.3e-12 | 40.1 | In-house | 54-287 (297) | alignment | ||
Range on Protein: 154-386
Range on HMM: 54-287/297.0
QSHSSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLV-QLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqES
. ..||... |||.|. .. |.|||| | | ..|. | | . | .||..|... . . ..| || . .. . .
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpl...astvadfwqmvweqGvvvivnltrleeegvkqckrywp.de
GAWLYANgFFVN--TRKVEKkENAKADMFVVELLPEGCSNAVmcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNS-PTVIASVNGSGRNAALLTLA
|. .| . |. . .. .. | . | . .| . . . |. | . . .. | | | | |. . .|.|| . . .
Gsevyhi.yevhlvsehiwc.ddylvrsfylknlqtsetrtv..tqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid
VVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.| ..|..| || |. . .|.|||. | . |. ..|
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 154-387 | 1.3e-11 | 39.1 | In-house | 26-264 (274) | alignment | ||
Range on Protein: 154-387
Range on HMM: 26-264/274.0
QSHSSRNRHTDYKCYDHNRIIV--QMCKD---DYINGSKINVPHFTPSIYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
....||... .. |... . .| .||| | .. . .|. . . .|..|||....|..| . .... .| . . | ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPl..pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae
GAWLYA--NGFFVNTRKVEKKENAKADMFVVEllpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA---KNENGN-SPTVIASVNGSGRNAALL
.. . ... ....|. .... . .|.. ... . |..| | ||. . .. ... ..|| . .|.|. | || . .
dyeiserygdveikvekiverndysvrklvlk....ylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi
TLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
. . || . . . .|| .| .| |.. || .. |
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 154-384 | 4.7e-09 | 30.3 | In-house | 53-282 (305) | alignment | ||
Range on Protein: 154-384
Range on HMM: 53-282/305.0
QSHSSRNRHTDYKCYDHNRIIVQ-MCKDDYINGSKINVPHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
. ..||..| | |.. . .. ||| . .| ... .| ....||| .| ... . . .... || . . . | |
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld..qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl
YA-NGFFVNTRKVEKKENAKADMFVVeLLPEGCSNAVMCSVYlHTYWKPLfgPDRF--GAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVED
.| |. | . |.. . || | || | | ||| ... . .. . | |. | || ..... . .
elksgivvenvsgskpmerdaeiqit.llnltysgdqkmsvr.hlqwtew..pdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyile
QLTRGKE-PKISEIVRTIREQRPQSVDSYIQYVSLY
... |. | . |.|...|.|| |... .||. ..
kiaenkpcppmpelvkalrdqrafsiqndvqylfih
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 154-234 | 3.3e-06 | 21.2 | In-house | 29-112 (297) | alignment | ||
Range on Protein: 154-234
Range on HMM: 29-112/297.0
QSHSS--RNRHTDYKCYDHNRIIVQ--MCKDDYINGSKINVPHFTPSIYLVQlPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEE
. || .||..| .| .|. .. . . |||| . |. .. . . ..|..||..|.... ... ..|. .|
krnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyil.aqGplsatvddfwtlvaeqdvrvivmvaklqe
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 155-388 | 6.7e-21 | 69.8 | In-house | 55-287 (298) | alignment | ||
Range on Protein: 155-388
Range on HMM: 55-287/298.0
SHSSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGA
. ..||..|. .|. |.... . |||| | .. . ... . | | . .||.|||.| .|. .|. .. ||| . . | . .| |.
enkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt...etvedFWrmvteedigtiVmltnleeldktkyhkywPde.gk
WLYaNGFFVNTRKVEKKENAKADMFVVELLPEGcsNAVMCSVYLHTYWKPLFGPDRFGAQIR--AAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVE
| . . |. .. |.. . . |. | . . .| | | . . . . ....||.| .. .| || . . |
ety.geitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvl
DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
... . . . ..|...|..||..|.. ||| .|.|.
ervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 155-386 | 9.2e-19 | 62.4 | In-house | 42-272 (314) | alignment | ||
Range on Protein: 155-386
Range on HMM: 42-272/314.0
SHSSRNRHTDYKCYDHNRIIVQMCKDD----YINGSKINVpHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGA
. ..|| .| ||. |.... ..| |||.. |. . |. ..| .. . |..|||.|..|.| .. ... | .. | . ...
enreknrsgdilaydrsrvflitidgdpssdyinaalids.ykrpaafivtqgPlq..etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev
wlYANgFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVED
| . . |. ..| ... . .| || | | .. . . .. | | . .. ... | .|... ..|. ..|.|| . .....| |
..ygd.ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
. | . . ..|.|.|.... |. ||. .| .
mieregvvdvfnavktlrsrkvnmveteeqykfiydv
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 155-391 | 6.8e-13 | 43.4 | In-house | 40-276 (281) | alignment | ||
Range on Protein: 155-391
Range on HMM: 40-276/281.0
SHSSRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHfTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESG
.||... ||. |. | . . |||| . .. . . |.. | | .....||..|. .. ... ...| | . . . ...
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvP...aslvafWqmvweqkvsaivmvtreieagklkChrYWPddns
AWLYANGFFVNTRKVEKKENAkADMFVVeLLPEGCSnaVMCSVYLHTYWKPLFGPDRFGAQIRAAHQI--AKNENGNSPTVIASVNGSGRNAALLTLAVV
. |.. .|.. ||.. . | . .| . . . .| | |. . . ... ..... . | || | || . ..| .
elkygdvtvkstaeeekatyi.erkfkl.eresget..reveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl
EDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
..... .| .....|. .|..| | . .|| .| | .
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 155-386 | 1.6e-12 | 41.5 | In-house | 44-231 (392) | alignment | ||
Range on Protein: 155-386
Range on HMM: 44-231/392.0
SHSSRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEELTnpaidklfcqesga
.||. . || .|... .. ..||.| | |. . . | |.. |.| .|||.||.|. |. .... .|
inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasld...dfwrmvfqenvttiamvtklkegd..............
wlyangffvntrkvekkenakadmfvvellpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNS-PTVIASVNGSGRNAALLTLAVVED
.| .. . | | | . . .. ... . . | .| | || . .... |
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvva
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
. . . . ..| ||..|| |.. || .| |
hakktrmvdvfnfvtnirrkrpymvqtkeqyafiyga
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 155-394 | 1.4e-11 | 38.4 | In-house | 46-290 (563) | alignment | ||
Range on Protein: 155-394
Range on HMM: 46-290/563.0
SHSSRNRHTDYKCYDHNRIIVQMCKD-----DYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQeSG
. .||... ||. |. .. . |||| . |. . . | | | .. |||... .. ... .|. .| .. | . . .
enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk...dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.de
AwLYANGFFVNTRKVEKKENAKADMFVVEL--L--PEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQ-IAKNENGNSPTVIASVNGSGRNAALLTL
. . . . |. . |.. .|.. | . | . . | |.| |. .. ... | |.. |.|. .| || .. |
s.etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivl
AVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTK
. |. . . . .....|| ||. | . ||. |. | .|..|
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 155-387 | 2.8e-11 | 38.1 | In-house | 47-284 (325) | alignment | ||
Range on Protein: 155-387
Range on HMM: 47-284/325.0
SHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPeELTNPAIDKLFCQESGA
..|| . .|..|.... || |||| | .. | |. .. ....||.|. .| | .. .| . . . .| |
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat...indlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgk
WLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCsvYLHTYWKPLFGPDRFGAQIRAA------H-QIAKNENGNSPTVIASVNGSGRNAALLT
|. |. | .|. . .. | .| . .| . . |. . . | . | . .. | .. .| .. ..| || ....
sktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkq..fqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis
LAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
| . ... . | . |. .|..||. |.. ||. .| |
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 155-391 | 3.8e-09 | 30.9 | In-house | 19-264 (270) | alignment | ||
Range on Protein: 155-391
Range on HMM: 19-264/270.0
SHSSRNRHTDYKCYDHNRIIVQMCKDD----YINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGA
.. ||..| . |.... ..| ||| .. . . |. ... ....|||....|. ... ... || . .. . .|..
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpt..tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke
WLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFG---------AQIRAAHQIAKNENGNSPTVIASVNGSGRNAAL
. . .......... . . ..| .| .. .. . .. | | . . . .|| .. |. . ..|... .| || |
kvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl
LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
..| . | . |. . .|.. .|..|.. |. || || | .
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 156-386 | 7.7e-18 | 59.4 | In-house | 58-290 (330) | alignment | ||
Range on Protein: 156-386
Range on HMM: 58-290/330.0
HSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqESGAW
.|| . ||..|.|... . |||| | |. . . | || . .||.|||... . .|. ... .| . . . . |..
nkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee...tvedfwrmiweqksativmltelkerkeekcaqywP.deGlv
LYANgFFVNTRKVEKKENAKADMFVVELLPEGC-SNAVMCSVYLHTYWKPLFG-PDRFGA--QIRAAHQIAKNENGNsPTVIASVNGSGRNAALLTLAVV
| | |. .... .. |.|. ||... ... .| | .| | .. .. . .. ... | |. | || ....| |
tyGn.irvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldav
EDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
... . . |.|. .| |||| | . ||. .| .
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 156-381 | 1.9e-16 | 54.9 | In-house | 41-265 (280) | alignment | ||
Range on Protein: 156-381
Range on HMM: 41-265/280.0
HSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPS---IYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
|.||. | ||. |.... . |||| . .|. . . |.. .. .....||..|........ ... | . . ... .
nlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPla..ktatdfWqmvweqksslivmlttlverGrvkChqyWPetedele
YAnGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHtyWKPLFGPDRFGAQIRAAHQIAKNENG-NSPTVIASVNGSGRNAALLTLAVVEDQL
|. .| |. .| ..... .|.. . .. .. || | || .. ... | .| ..|.|. | || |..| . .
yg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla..WpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalali
TRGKEPKISEIVRTIREQRPQSVDSYIQYV
. .. . .||||.|.|| |.. ||
eaaepvypldivrtmrdqramlvqtasqyk
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 156-388 | 2.5e-16 | 54.4 | In-house | 48-278 (564) | alignment | ||
Range on Protein: 156-388
Range on HMM: 48-278/564.0
HSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHfTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGA
..|| . |||.|.. .. . |||| | |. . .. |. | |. ...|.||| |. ....|. .. . || .. ..| . .. |
NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPla...etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gt
WLYaNGFFVNTRKVEKKENAKADMFVVelLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVED
| ... |. . |.... | . . |.. . . .| | |. . .. ... . ||... |.|. .| || . ... .. .
ety.geltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamle
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
... | | ..|...|.||. |.. ||. .. | .
rikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 156-392 | 1.8e-09 | 31.8 | In-house | 38-278 (287) | alignment | ||
Range on Protein: 156-392
Range on HMM: 38-278/287.0
HSSRNRHTDYKCYDHNRIIVQMCK---DDYINGSKInvPHFT-PSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAW
..||..| .|..|... |||| . . .| ... . . .| .|||.|.... .| ...| | . . | . .
avkknryadvlPiddtrvllsaegelGsdyinanyv..asytddeafiaaqgPiaa..tvrdfwravletrsasvitmtreveearlkcykywPer.evP
LYANGFFVNTRKVEKKENAkADMFVVELLPEGCSN-AVMCSVYLHTYWKPLFGPD-----RFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLA
. |. | . ..|| . . |. . |. . | .. . | || ... ..|.. .. | |. | || ||..
mrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl
VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
|. ..| . .. .| .||.| | . .|. || | |
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 157-386 | 1.2e-41 | 138.1 | Pfam-A | 2-232 (235) | alignment | ||
Range on Protein: 157-386
Range on HMM: 2-232/235.0
SSRNRHTDYKCYDHNRIIV-QMCK-DDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA
...||..|. .||..|. . . .. |||| . .. . . .. . | | ... |.|||.|..|..... .... || . .... . .|.. |.
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty
NGFFVNTRkVEKKENAKADMFVVELLPEGCSNA---VMcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQ
. ..|... ...||. |. .. . | . ... . ... .| |. |. . .. ... |.. . ..|.|. . .|.|| . ...| .. .|
gdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|....|... .||...|.|||..|.|. ||. ||.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflyka
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 157-386 | 1.2e-41 | 138.1 | In-house | 2-232 (235) | alignment | ||
Range on Protein: 157-386
Range on HMM: 2-232/235.0
SSRNRHTDYKCYDHNRIIV-QMCK-DDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA
...||..|. .||..|. . . .. |||| . .. . . .. . | | ... |.|||.|..|..... .... || . .... . .|.. |.
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty
NGFFVNTRkVEKKENAKADMFVVELLPEGCSNA---VMcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQ
. ..|... ...||. |. .. . | . ... . ... .| |. |. . .. ... |.. . ..|.|. . .|.|| . ...| .. .|
gdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|....|... .||...|.|||..|.|. ||. ||.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflyka
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 157-387 | 9.9e-22 | 72.3 | In-house | 10-238 (250) | alignment | ||
Range on Protein: 157-387
Range on HMM: 10-238/250.0
SSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPaIDKLFCQESgAWL
.||..|. .|. |.... | |||| | ... . . . | | ....|.|||.|..|. .|. ... .| . . . . | |
keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPl...qatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.aek
YANgFFVNTRKVEKKENAKADMFVveLLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN--GNSPTVIASVNGSGRNAALLTLAVVEDQ
| . |. . |.. . . .. | . .. .. . .. | |. | . ... .... ||.| .. .| || | ... | ..
yGd.vtvsllskeefadytkrklk..lskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler
LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
| . | . ......|..||..|.| |||..|..
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeii
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 157-387 | 3.9e-19 | 63.9 | In-house | 49-282 (307) | alignment | ||
Range on Protein: 157-387
Range on HMM: 49-282/307.0
SSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPkMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWL
.||. | | .|..|.... . |||| | |. . . . | | ... ...|||.. . ... ... .| .. ..| . .|
alknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdP.vea..tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devq
YAnGFFVNTRKVEKKENAKADMFVVELLP-EG--CSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVE
| |.. . ||... . | |. . | .| || |. . .. .|. ... .|| |. .|.|| . ...|...
yg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsll
DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
.|| .. .| |.|. .|.||. |.|. ||| || |
qqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 157-387 | 3.7e-16 | 54.0 | In-house | 48-275 (288) | alignment | ||
Range on Protein: 157-387
Range on HMM: 48-275/288.0
SSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
..||. . ||..|. .. . |||| | |.. . . | | .|.| ..||..|. .. .|. .. | . .. . .. .
akknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv...ndfWelvyenktstivmltelveggktkCeeYWPdadkpkn
YANgFFVNTRKVEKKENAKADMFVVEllpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN-SPTVIASVNGSGRNAALLTLAVVEDQL
| . . | ......|. . .| . . | .. | |. . .|. ... . | .. .| || ..| . |..
yGs.vtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidav
TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
. . . ..| .|.||.. |. ||. .| .
eeedyiDvagtvaklRkqRallvqtlkqYefiyevl
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 157-388 | 3.4e-14 | 47.7 | In-house | 52-281 (297) | alignment | ||
Range on Protein: 157-388
Range on HMM: 52-281/297.0
SSRNRHTDYKCYDHNRIIVQMCKDD----YINGSKINVPHFtpSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCqESGAWL
...|... || .|..... || |.| | ... . . | |. .. |..||..|..|| .|. ... .| .. . . ..|
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat...vadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvtt
YANgFFVNTRKVEKKENAKADMFVVEllPEGCSNAVMCSVYLHTYWKPLFGPD--RFGAQIRAAHQIAKN--ENGNSPTVIASVNGSGRNAALLTLAVVE
. . | . |...| ..|. . . . | ...| . . . . ... |. .| ..| .. ..| || . |||. |
fGd.vsvvllsvsereGfikrelevt..kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv
DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
. | || | ..|. .|..||. | || .| | .
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 157-386 | 4.3e-14 | 47.3 | In-house | 9-236 (239) | alignment | ||
Range on Protein: 157-386
Range on HMM: 9-236/239.0
SSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARpeeLTNPaiDKLFCQEsgAWL
..||... |||.|.... . |||| | . .| |. . . .|||....|. . ... | . | |.. |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei..ssgdfwrmmwqerrcvivmltg...lieg..hkkkchq..ywp
YANGFFVNTRKVEKKENAKADMFVVELLPE--GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVED
. ..| | .| . || . .. | .. | | | |. | . ..|.|. | | || | || |.| . .
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
| . | | . |..|||.||. |.. ||| ...|
qakkqktvdifnyvkairedrphmvqtseqyvfihla
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 157-386 | 4.3e-14 | 47.3 | In-house | 8-235 (239) | alignment | ||
Range on Protein: 157-386
Range on HMM: 8-235/239.0
SSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARpeeLTNPaiDKLFCQEsgAWL
..||... |||.|.... . |||| | . .| |. . . .|||....|. . ... | . | |.. |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei..ssgdfwrmmwqerrcvivmltg...lieg..hkkkchq..ywp
YANGFFVNTRKVEKKENAKADMFVVELLPE--GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVED
. ..| | .| . || . .. | .. | | | |. | . ..|.|. | | || | || |.| . .
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
| . | | . |..|||.||. |.. ||| ...|
qakkqktvdifnyvkairedrphmvqtseqyvfihla
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 157-386 | 2.8e-12 | 41.2 | In-house | 50-274 (315) | alignment | ||
Range on Protein: 157-386
Range on HMM: 50-274/315.0
SSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHfTPSIYL-VQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsgAW
.||. . ||. |. . . . ||.| . |. . |. | |. | .|..|||.||.|.. .. ... | . .| . .
kqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpn...vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kv
LYanGFFVNTRKVEKKEnakaDMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN--ENGNSPTVIASVNGSGRNAALLTLAVVED
.| | . ||| |... . . | | . . | || | | .. . .. .| .| .. |. .| || ...|| | |
iy..Gkitvtrkseevn....teytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|. . . .... .|..| . |.. || .| |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 157-393 | 2.4e-08 | 29.6 | In-house | 47-282 (314) | alignment | ||
Range on Protein: 157-393
Range on HMM: 47-282/314.0
SSRNRHTDYKCYDhNRIIVQM---CKDDYINGSKINVPhftPSIYLVQLPkMDSVdaVEEF----------WRVVF--HEQCQTVHI-------------
..||..| ..| || |.. |||| | .. . . | | .. . |. | ||.|. .. ....
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgp.leit..vvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL
--------IARPEELTnpaidklfcqesgawlyaNGFFVNTRKVEKkenakadmfvvELL--PEGCSNAVmcSVYLHTYWKPlFGPDrFGAQIRAAHQIA
. .. ... | . . . | | | || ..... ||.. . .... ...... ..
daAlgKtpllildgng..................neptaadlellk...........eelydpelferlg..ikylripvpD.gsap.lledfdeflefi
KNENGNSPTVIASVNGSGRNAALLTLAVVEDQLtrgKEpKISEIVRTIREQRP-----QSVDSYIQYVSLYMATNWLIKT
.. . ..|... | || . ....| . .| . . |... .|..|| .. ...||. ..| . ..|.
eeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 157-384 | 1e-07 | 25.9 | In-house | 38-262 (281) | alignment | ||
Range on Protein: 157-384
Range on HMM: 38-262/281.0
SSRNRHTDYKCYDHNRIIVQM-----CKDDYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAW
.||... | | |. ... ||| | | . | | || .. .|||....|. .. .... | . | ... .
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkket...radfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc
LYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNavMCSVYLHTYWKPLFGPDRFGAQIRAAHQIaknENGNSPTVIASVNGSGRNAALLTLAVVEDQL
| . . |. | ..| || . . . .| | |. .. ..| .| || | || .|... . . .
lqfdklsvsyedstv..nkslvttrlnlsyegetr..lithwlwkewpdwqvpessevmlkilrki...rarstppvihcsagvgrsgtlmaveialqsi
-TRGKEPKISEIVRTIRE-QRPQSVDSYIQYVSLY
.. | | .|| .| | ||.. ||. ..
hshftlpdikqivshlrvtgraasvqtlqqymliw
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 158-387 | 1.5e-14 | 49.2 | In-house | 27-251 (284) | alignment | ||
Range on Protein: 158-387
Range on HMM: 27-251/284.0
SRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHfTPSIYL-VQLPKMdsvDAVEEFWRVVFHEQCQTVHIIArpeeltnpaidKLFCqeSGAWL
.|| .. .|.|.. .. |||| | |. . |. | |. .....|||... .| |. ... | | | |
dknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPld...ntladfWrmiweyncstivllt...........kdkc..sqywp
YA-----NGFFVNTRKVEKKENakadmFVV---ELLPEGCSNAVMCSVYLHTYWKPLFG-PDRFGAQ---IRAAHQIAKNENGNSPTVIASVNGSGRNAA
. | |. ||. |. .|| || .| . . | | | || .. . . . ||.... |. |.|| .
lkivikeerfkvkvdsveesee.....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv
LLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
..| |. |.. . | . ..|| .|.||.. |....|| .|.|
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 158-387 | 2.1e-14 | 48.6 | In-house | 63-287 (319) | alignment | ||
Range on Protein: 158-387
Range on HMM: 63-287/319.0
SRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVpHFTPSIYL-VQLPKMdsvDAVEEFWRVVFHEQCQTVHIIArpeeltnpaidKLFCqeSGAWL
.|| .. .|.|.. .. |||| | .. . . |. | |. .....|||... .| |. ... | | | |
dknriinilafdknvvklerliGeefsdyinasfvtG.yqrkdkyiaaqGPld...ntladfWrmiweyncstivllt...........kdkc..sqywp
YAN-----GFFVNTRKVEKKENakadmFVV---ELLPEGCSNAVMCSVYLHTYWKPLFG-PDRFGAQ---IRAAHQIAKNENGNSPTVIASVNGSGRNAA
| |. ||. .. .|| || .| . . | | | || .. . . . ||.. . |. |.|| .
lkivikeerfkvkvdsveetae.....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv
LLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
..| |. |.. . | . ..|| .|.||.. |....|| .|.|
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 158-384 | 1.1e-13 | 45.5 | In-house | 58-276 (290) | alignment | ||
Range on Protein: 158-384
Range on HMM: 58-276/290.0
SRNRHTDYKCYDHNRIIVQMCK-DDYINGSKINvpHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANG
.||. | | | |.|.. ||. .. . . | | . | .| ..||.| .|. .. .. | .. .. . ...| |
kknrykdvvcndktrvilkdGydGdyvhanyvk..GlkamfiltqGalkd...tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe
FFV-NTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAKNengNSPTVIASVNGSGRNAALLTLAVVEDQLTRGK
. | . . .| .| . .. | .| . . . | . | .| . . | . | |. | || .. .. | . |. ||
itvlcseeddkdaniikktlsvrdkdsGkehklk..hlkikswpdksvalstlallrtlrilrka...sGpvvvhcsaGiGrtGtfvaievglqilldGk
EPKISEIVRTIREQRPQSVDSYIQYVSLY
| .. ..||..|. | .||. |||. |
eldlldlvralrnsrlnsvqvdiqylalv
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 158-391 | 1.9e-13 | 45.9 | In-house | 3-171 (182) | alignment | ||
Range on Protein: 158-391
Range on HMM: 3-171/182.0
SRNRHTDYKCYDHNRiivqmcKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIArpEELTNPaidklfcqesgawlyangf
..||..|. .|||.| |||| . . .. . . . | | .. |..|.| . .....|. .. ||| .|
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt..eelywp...................
fvntrkvekkenakadmfvvellpegcsN--AVMCSVYLHTYWKPLFGPDrFGAQIRAAHQIAKnenGNSPTVIASVNGSGRNAALLTLAVVEDQltrgk
. . ||.. | || . .. ... . . |... | || ..| . ... .
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....
EPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
. . |.|...|..||..| . ||. |..| .|.
gvsleeavklvrsrRpgmvitpnqyfflqlallell
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 158-384 | 1.3e-12 | 42.4 | In-house | 5-232 (237) | alignment | ||
Range on Protein: 158-384
Range on HMM: 5-232/237.0
SRNRHTDYKCYDHNRIIVQMC--KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYAn
.||. . ..|||.|.... . . |||| . .. || |. ..| . ..||..|. |.| . ... | . | . . |
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgples..scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg.
gffVNTRKVEKKENaKADMFVVELLPE---GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG---NSPTVIASVNGSGRNAALLTLAVVED
| | . |||. .| | || . . | | | |.. | .| ..| .. . .| .| | || . .| . .
...vltvslkkkee.fsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr
QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
| | | . | .| |.|| ... ||| ..
qakekkvvdiynyvysieedrpyiiqtkdqyvfih
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 158-386 | 2.9e-11 | 37.2 | In-house | 45-271 (515) | alignment | ||
Range on Protein: 158-386
Range on HMM: 45-271/515.0
SRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEELtnpaiDKLFCQESGAWLY
..||. . || .|... . . ||.| |.|. . . | |. ||| .|||.|..|. |. .... .| || | .
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd...dfWrlvlqenvttiamvtklkeg.....dkikcgkyWPdkp
ANGFFVNTRKVEK-KENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVEDQL
.. . ||| .| ... .| ... . | | | . . .. ... ... . | .| | || .... | .
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha
TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.. . ..|. ||..||. | || .| |
kttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
|
|||||||||
subfamily_egg_pd | Subfamily egg | 158-407 | 3.7e-11 | 37.3 | In-house | 42-286 (307) | alignment | ||
Range on Protein: 158-407
Range on HMM: 42-286/307.0
SRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLY
. | .| | |. ... ||.| ... . | | | ..|..|||.|| |..| . ... | . ... . .
ekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplk...ntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtv
ANGFFVNTRKVEKKENAKADMFVVELlpEGCSnavMCSVYLHtYWKplfGPDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLT
.. ... ||..| . . . | | .| .|. | .. ... .. | | |.|. ...| . |.|... . .|
pGslrienlkvdskadplfrvtklkl..vGgd...deerfle.hwq...gdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsll
RGKEPK--ISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPSGHEVVSKIKK
|| | . . | .| .|. ||.| ..|. .| .... . | .|. ..
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyer
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 180-384 | 2.8e-11 | 38.9 | In-house | 2-163 (174) | alignment | ||
Range on Protein: 180-384
Range on HMM: 2-163/174.0
DDYINGSKINVPHFTPSIYLVQLPKMdsvdaveeFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQesgawlyangffvntrkvekkenakadmfvvel
.|||| | ... . || ... | | ||. .......|| ...|| . . ..
sdyinaspldlsyitprliagqgpla........fwemlkelgittvvmlleekelglykcinywpe.................................
lpEGCSNAVMCSVYLHTYWKPLFGPDRFG--AQIRAAHQIAKNeNGNSPTVIASVNGSGRNAALLTLAVVEDQLTrGKEPKISEIVRTIREQRPQSVDSY
. . ||.. | || ....... .. ... |... | || ..| . .. .| . .. ..||..| |||..| .
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp
IQYVSLY
|| ||
sQyrfly
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 180-390 | 3e-11 | 38.8 | In-house | 5-160 (172) | alignment | ||
Range on Protein: 180-390
Range on HMM: 5-160/172.0
DDYINGSKINVPHFTPSIYLVQLPkmdSVDAVEEFWRVVFHEQCQTVHIIARPeeltnpaidklfcqesgawlyangffvntrkvekkenakadmfvvel
.|||| | ..... .... | | ...||| . ....... . .
sdyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnltel...............................................
LPEGCSNAVMCSVYLHTYWKPLFGPdRFGAQIRAAHQIAK--NENGNSPTVIASVNGSGRNAALLTLAVVEdqltrgKEPKISEIVRTIREQRPQSVDSY
| . . ||...| | . ... ..| . ... . |... . | || ..| . .. . .. |.|...||.||..| .
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp
IQYVSLYMATNWL
|| ||. ..|
sqyrflyyfekll
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 180-393 | 1.3e-07 | 27.1 | In-house | 4-227 (272) | alignment | ||
Range on Protein: 180-393
Range on HMM: 4-227/272.0
DDYINGSKINVPhftP-----S-IYLVQLPKMDSvdaVEEFWRVvFHEQCQTVHIIARPEELTNPAIDKLFC----------QESGAWLYANGFFVNTRK
..||| . .. . .|. . | . ...||| .... |. . ..||. |.. .| . . ..| . .
sgyiNardvggy...grvvkpgrlyrsggplplt...aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls
VEKKENAKADMFVVELL-PEGCSNAVMCSVYlhTYWKPLFGPDRFgaqIRAAHQIAKNengNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPK----
.| ... ......|| . | . ||. .| | | |. .... .. . . | .. | .| . . | . .... .
eellldyilrellltlllsagearevmhlhy..tdwpdhgvpqea...llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll
----ISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
. |.|. .|.|||..| .. ||. ||.| |...
tnlyleeaveelraqrpgavqteeqylflyeallellrs
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 188-386 | 4.9e-06 | 21.7 | In-house | 6-148 (151) | alignment | ||
Range on Protein: 188-386
Range on HMM: 6-148/151.0
INVPHFTPSIYLVQLPkmdsvdaVEEFWRVVFHEQCQTVHIIARPEELTnpaIDKLFCQESGawlyangffvntrkvekkenakadmfvvellpegcsna
|| |. .|. . | ..|.. . .....|. . .|| .. ...| |
infsyvtgglyrsggp.......ladflellkelgiktivnlrseeerg...ycpeylpelg......................................
vmcS--VYLHTYWKPLFGPDRFGAQIRAAHQIAKNeNGNSPTVIASVNGSGRNAALLTLAVVEDQltrgkePKISEIVRTIREQRPQSVDSYIQYVSLYM
.... | .| . . .......... . ..| |... | || ..| | . . . |... .|..|| .| . |.. ...
...ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
A
|
a
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 193-416 | 2.7e-36 | 118.9 | In-house | 113-335 (346) | alignment | ||
Range on Protein: 193-416
Range on HMM: 113-335/346.0
FTPSIYLVQLPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAiDKLFCQESGAWLYANGFFVNTRKVEKKENAKAdmFVVELLPEGCSNAVMCSV
| . ..|||.|.. ||.|| ....|| . |... . | | . || .| | . |. .|.| |. . . | . .|.|||| |..|.| |
fehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntt.tslfndenggyqytgkmfinnrradvsgdpke..ytievlpegnsdsvicqv
YLHTYWKPLFGPDRFGAQIRAAHQIAKNEN-GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
. |. || | | . |. ||. ... | . |. |.|| ... .|| | || | ||...|..||| .|.|. || |.| |
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
KTKLPSGHEVVS-KIKKFNEKATRSL
| .. | .|..| .. . .
arkrggkkapvnkdinrfidelaeis
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 193-392 | 3.7e-11 | 38.6 | In-house | 15-174 (176) | alignment | ||
Range on Protein: 193-392
Range on HMM: 15-174/176.0
FTPSIYLVQLP---KMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLyangffvntrkvekkenakadmfvvellpegcsnavm
.....| .| . .. ...|.. ........| . . || .. .. .. .. .
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................................
csVYLHTYWKPLFGPDRfGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDqltrGKEPKISEIVRTIREQRP-QSVDSYIQYVSLYMATN
|||. | || . ... .| . . . |... . | || ..|. . .| .| .. |.....||||| ..| . || ||..
..qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefel
WLIK
.|.|
lllk
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 211-385 | 2.2e-09 | 32.7 | In-house | 22-144 (152) | alignment | ||
Range on Protein: 211-385
Range on HMM: 22-144/152.0
VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFcqesgawlyangffvntrkvekkenakadmfvvellpegcsnavmcsVYLHTYWKPLFGPDRFGAQ
...||| . . ...|. . ...||. . .... |||..| ||
ladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpwpDhgvpdlsqll
IRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVEdqltrgKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
. . . | | ... . |... . | || ..| . .. . .. |.|. .||.||..| . |. ||
lflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 243-395 | 5.9e-13 | 43.0 | In-house | 180-342 (347) | alignment | ||
Range on Protein: 243-395
Range on HMM: 180-342/347.0
LFCQESGAWLYANGFFVNTRKVEKKENAKADM--FVVELLPEGCSNAVMCSVYLHTYWKPLFGPDR---FGAQIRAAHQIAK-----NENGNSPTVIASV
.| |. .| .|...|||.|| . .|. | . ||.. ||||.| .. || | | || | .|| . . | . .| |.
ffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcd
NGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
| | |... ... .|. || | .. . .|.|| | | |. . .| ||
lgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylklkl
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 275-390 | 6.2e-06 | 21.5 | In-house | 34-142 (145) | alignment | ||
Range on Protein: 275-390
Range on HMM: 34-142/145.0
FVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDqltrgKEPKISEIVRTIREQRPQSV
. . .|.... .. ||.. | || . ... ..| . . . |... | || ..| . .. . . |... .|.|||..|
lnltselellerlgi..qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav
DSYIQYVSLYMATNWL
. |. ||.. .|
pnpgqlrflyefelel
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 276-387 | 6.9e-06 | 21.4 | In-house | 33-141 (144) | alignment | ||
Range on Protein: 276-387
Range on HMM: 33-141/144.0
VVELLPEGCSNAVMCS--VYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEdqlTRGkePKISEIVRTIREQRPQS
|. | .| . . . |||. | || . ... . | . . . |... | || ..| .. .. ..| . |... .|..||..
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpga
VDSYIQYVSLYMAT
| . |. |..
vpnpgqlrfLleye
|
|||||||||
PTPc_DSPc_SM00012 | 290-387 | 1.1e-17 | 59.5 | In-house | 2-103 (105) | alignment | |||
Range on Protein: 290-387
Range on HMM: 2-103/105.0
CSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN---SPTVIASVNGSGRNAALLTLAVVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYM
...| .| |. |.. . ... ... ||.| . .|.|. . .| || . . .|... .||... ||..|..||. .|.|||..|... ||. ||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
AT
|
al
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 323-386 | 2.9e-06 | 21.4 | In-house | 227-290 (297) | alignment | ||
Range on Protein: 323-386
Range on HMM: 227-290/297.0
GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
| .... | || .. |. ..| ... |.. |.. .||||.. | . |. || |
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
|